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https://www.readbyqxmd.com/read/29909373/what-insights-do-patients-and-caregivers-have-on-acute-kidney-injury-and-posthospitalisation-care-a-single-centre-qualitative-study-from-toronto-canada
#1
Samuel A Silver, Marianne Saragosa, Neill K Adhikari, Chaim M Bell, Ziv Harel, Andrea Harvey, Abhijat Kitchlu, Javier A Neyra, Ron Wald, Lianne Jeffs
OBJECTIVES: Hospitalisation with acute kidney injury (AKI) is associated with short-term and long-term adverse events, but patient and caregiver experiences with AKI are not well described. We sought to better understand patient and caregiver perspectives after a hospitalisation with AKI to inform discharge strategies that may improve outcomes for this high-risk population. DESIGN: Qualitative study with semistructured interviews. SETTING: Tertiary care hospital in Toronto, Ontario, Canada...
June 15, 2018: BMJ Open
https://www.readbyqxmd.com/read/29908974/severe-infrarenal-atheroma-load-in-open-aortic-aneurysm-repair-is-not-a-risk-factor-for-postoperative-acute-kidney-injury
#2
S Ooms, B Nemeth, J J Wever, B Knippenberg, H van Overhagen, R G Statius van Eps
OBJECTIVES: Acute Kidney Injury (AKI) after open aortic repair is subject to multiple patient- and operation-related variables. Hostile neck morphology in open aneurysm repair is thought to contribute to this AKI risk post-operatively. The aim of this study was to evaluate if large neck atheroma is a possible risk factor in the postoperative development of AKI. METHODS: Retrospectively 137 patients were evaluated for neck atheroma and AKI incidence. Atheroma load measurements were performed by two different techniques...
June 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29908852/early-postoperative-hypoalbuminemia-is-a-risk-factor-for-postoperative-acute-kidney-injury-following-hip-fracture-surgery
#3
Kyun-Ho Shin, Seung-Beom Han
INTRODUCTION: Acute kidney injury (AKI) is a common and serious complication after hip fracture surgery in older adults. Hypoalbuminemia is a known independent risk factor for AKI. However, few studies have investigated the relationship between early postoperative hypoalbuminemia and AKI after hip fracture surgery. Therefore, we sought to determine the incidence of and risk factors for AKI and the effects of early postoperative hypoalbuminemia on AKI incidence after surgery for hip fractures, especially intertrochanteric fractures of the proximal femur...
May 2, 2018: Injury
https://www.readbyqxmd.com/read/29908137/personality-high-risk-behaviors-and-elevated-risk-of-unintentional-deaths-related-to-drug-poisoning-among-individuals-with-spinal-cord-injury
#4
James S Krause, Yue Cao, Nicole D DiPiro, Emma Cuddy
OBJECTIVE: To identify risk and protective factors for unintentional death related to drug poisoning from prescription medications, including opioid-related deaths, and death due to all other causes among participants with spinal cord injury (SCI). DESIGN: Prospective cohort study. SETTING: Large specialty hospital in the Southeastern United States. PARTICIPANTS: Two cohorts of SCI participants, totaling 3070 adults (>18 years old) with chronic (>1 year) traumatic SCI...
June 13, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29907353/determinants-of-skeletal-muscle-protein-turnover-following-severe-burn-trauma-in-children
#5
Ioannis Malagaris, David N Herndon, Efstathia Polychronopoulou, Victoria G Rontoyanni, Clark R Andersen, Oscar E Suman, Craig Porter, Labros S Sidossis
BACKGROUND & AIMS: Burns remain the fifth cause of non-fatal pediatric injuries globally, with muscle cachexia being a hallmark of the stress response to burns. Burn-induced muscle wasting is associated with morbidity, yet the determinants of muscle protein catabolism in response to burn trauma remains unclear. Our objective was to determine the effect of patient and injury characteristics on muscle protein kinetics in burn patients. METHODS: This retrospective, observational study was performed using protein kinetic data from pediatric patients who had severe burns (>30% of the total body surface area burned) and underwent cross-limb stable isotope infusions between 1999 and 2008 as part of prospective clinical trials...
June 4, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29907203/bile-and-circulating-hmgb1-contributes-to-systemic-inflammation-in-obstructive-jaundice
#6
REVIEW
Runkuan Yang, Shengtao Zhu, Soeren Erik Pischke, Hakon Haugaa, Xiaoping Zou, Tor Inge Tonnessen
BACKGROUND: Obstructive jaundice (OJ) patients with cholangitis are prone to sepsis; however, the underlying mechanisms are still not clear and need to be clarified. METHODS: Analyzing all available published data related to the title of this article. RESULTS: OJ leads to absence of gut luminal bile and accumulation of hepatic and circulating bile acids. Absence of gut luminal bile deprives the gut from its antiinflammatory, endotoxin-binding, bacteriostatic, mucosal-trophic, epithelial tight-junction maintaining, and gut motility-regulating effects, leading to gut bacterial overgrowth, mucosal atrophy, mucosal tight-junction loss, and gut motility dysfunction...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907132/association-between-multiple-comorbidities-and-self-rated-health-status-in-middle-aged-and-elderly-chinese-the-china-kadoorie-biobank-study
#7
Xingyue Song, Jing Wu, Canqing Yu, Wenhong Dong, Jun Lv, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhengming Chen, An Pan, Liming Li
BACKGROUND: Understanding the correlates of self-rated health (SRH) can help public health professionals prioritize health-promotion and disease-prevention interventions. This study aimed to investigate the association between multiple comorbidities and global SRH and age-comparative SRH. METHODS: A total of 512,891 participants aged 30-79 years old were recruited into the China Kadoorie Biobank study from ten regions between 2004 and 2008. Multivariate logistic regression models were used to estimate the odds ratios (ORs) for the associations between comorbidities (including diabetes, hypertension, coronary heart disease, rheumatic heart disease, stroke, tuberculosis, emphysema/bronchitis, asthma, cirrhosis/chronic hepatitis, peptic ulcer, gallbladder disease, kidney disease, fracture, rheumatic arthritis, psychiatric disorders, depressive symptoms, neurasthenia, head injury and cancer) and SRH...
June 15, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29906433/complex-robotic-lower-urinary-tract-surgeries-in-patients-with-previous-open-surgery
#8
Patricio C Gargollo, Candace Granberg, Edward Gong, Duong Tu, Benjamin Whittam, Daniel Dajusta
PURPOSE: We describe our experience with robot assisted complex lower urinary tract reconstruction (CUTR) in patients with previous open abdominal surgery (PAS). MATERIALS AND METHODS: Patients with any PAS undergoing robot assisted CUTR were included. CUTR was defined as bladder neck reconstruction (BNR) or continent catheterizable conduits (CCC) or both, redo surgery at the bladder neck for persistent incontinence, or any of the above with an antegrade enema channel creation (MACE)...
June 12, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29906381/points-pearls-management-of-multiply-injured-pediatric-trauma-patients-in-the-emergency-department
#9
Andria Tatem, Rupa Kapoor, Bryan Wilson
Management of the child with multiple traumatic injuries can be challenging, and important injuries may not be readily recognized. Early recognition of serious injuries, initiation of appropriate diagnostic studies, and rapid stabilization of injuries are key to decreasing morbidity and mortality in the multiply injured pediatric trauma patient. The differential diagnosis for these patients is wide, and treatment is targeted to the specific injuries. In this issue, a systematic approach to the multiply injured pediatric patient will be reviewed, with specific attention to commonly missed injuries and those injuries that may cause significant morbidity or mortality...
June 1, 2018: Pediatric Emergency Medicine Practice
https://www.readbyqxmd.com/read/29905916/epidemiological-trends-of-traumatic-brain-and-spinal-cord-injury-in-puerto-rico-from-november-10th-2006-through-may-24th-2011
#10
Ricardo H Brau, Yaritza Acevedo-Salas, Katya Giovannetti
OBJECTIVE: According to the Centers for Disease Control and Prevention (CDC), injury to the central nervous system (CNS) continues to be a leading cause of injury-related morbidity and mortality in the US today. METHODS: A prospective cohort study was performed to determine the incidence of all traumatic CNS injuries. Descriptive variables were presented as frequencies and percentages. Quantitative variables were expressed as means and averages (plus/minus standard deviation); bivariate cross-tabulation and multiple regression analyses were employed to identify risk factors and compare epidemiological patterns of injury related variables...
June 2018: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29905647/the-associations-between-falls-fall-injuries-and-labor-market-outcomes-among-u-s-workers-65-years-and-older
#11
Kenneth Scott, Gwenith G Fisher, Anna E Barón, Emile Tompa, Lorann Stallones, Carolyn DiGuiseppi
OBJECTIVE: To examine whether falls are associated with the subsequent ability to work among workers 65 years and older. METHODS: This longitudinal cohort study followed older workers enrolled in the Health and Retirement Study. Outcomes included time to health-related work limitation and to labor force exit. RESULTS: After adjustment multiple falls with or without a medically-treated injury were associated with time to limitation (HR = 1...
June 13, 2018: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29904601/incidence-and-risk-factors-for-complications-after-definitive-skeletal-fixation-of-lower-extremity-in-multiple-injury-patients-a-retrospective-chart-review
#12
Thananit Sangkomkamhang, Wilaiphorn Thinkhamrop, Bandit Thinkhamrop, Wongsa Laohasiriwong
Background : The management of multiple injuries is complex. Type and timing of treatment for lower extremity fractures is a controversial subject. Although many studies have demonstrated the safety and effectiveness of early treatment, others have suggested that early definitive stabilization may cause complications, especially with chest and head injuries. The aim of this study was to determine the complications and effects of timing of fixation, and investigate risk factors for complications in multiple injuries patients with lower extremity fractures...
2018: F1000Research
https://www.readbyqxmd.com/read/29904388/niches-for-the-long-term-maintenance-of-tissue-resident-memory-t-cells
#13
REVIEW
Shiki Takamura
Tissue-resident memory T cells (TRM cells) are a population of immune cells that reside in the lymphoid and non-lymphoid organs without recirculation through the blood. These important cells occupy and utilize unique anatomical and physiological niches that are distinct from those for other memory T cell populations, such as central memory T cells in the secondary lymphoid organs and effector memory T cells that circulate through the tissues. CD8+ TRM cells typically localize in the epithelial layers of barrier tissues where they are optimally positioned to act as sentinels to trigger antigen-specific protection against reinfection...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29904333/grape-seed-proanthocyanidin-extract-supplementation-affects-exhaustive-exercise-induced-fatigue-in-mice
#14
Liu Xianchu, Liu Ming, Liu Xiangbin, Zheng Lan
Background: Grape seed proanthocyanidin extract (GSPE) has been extensively reported to possess a wide range of beneficial properties in multiple tissue damage. Previous studies have shown that exhaustive exercise-induced fatigue associates with oxidative stress injury, inflammatory response, and mitochondrial dysfunction. Objective: The aim of this study is to investigate the anti-fatigue effects of GSPE in mice and explore its possible underlying mechanism. Design: The mouse model of exhaustive exercise-induced fatigue was established by using the forced swimming test, and GSPE was orally treated for successive 28 days at 0, 1, 50 and 100 mg/kg/day of body weight, designated the control, GSPE-L, GSPE-M and GSPE-H groups, respectively...
2018: Food & Nutrition Research
https://www.readbyqxmd.com/read/29904188/a-mapping-review-of-randomized-controlled-trials-in-the-spinal-cord-injury-research-literature
#15
REVIEW
Amanda McIntyre, Brooke Benton, Shannon Janzen, Jerome Iruthayarajah, Joshua Wiener, Janice J Eng, Robert Teasell
STUDY DESIGN: Mapping Review. OBJECTIVE: The objective of this study was to map out and characterize the quantity and quality of all published spinal cord injury (SCI) randomized controlled trials (RCTs) with respect to number, sample size, and methodological quality between January 1970 and December 2016. SETTING: Not applicable. METHODS: A literature search of multiple research databases was conducted. Studies adhering to the following criteria were included: the research design was an RCT; written in English; participants were >18 years; and the sample was >50% SCI...
June 14, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29903699/a-putative-role-of-apolipoprotein-l1-polymorphism-in-renal-parenchymal-scarring-following-febrile-urinary-tract-infection-in-nigerian-under-five-children-proposal-for-a-case-control-association-study
#16
Emmanuel Ademola Anigilaje
BACKGROUND: Although urinary tract infection (UTI) resolves with prompt treatment in a majority of children, some children, especially those aged less than 5 years, also develop renal parenchymal scarring (RPS). RPS causes high blood pressure that may lead to severe chronic kidney disease and end-stage renal disease (ESRD). Although the risk of UTI is higher in white children than in black children, it is unknown whether RPS is more common in white children than in black children as data are scarce in this regard...
June 14, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29903544/the-impact-of-traumatic-experiences-on-risky-sexual-behaviors-in-black-and-white-young-adult-women
#17
Kimberly B Werner, Renee M Cunningham-Williams, Whitney Sewell, Arpana Agrawal, Vivia V McCutcheon, Mary Waldron, Andrew C Heath, Kathleen K Bucholz
BACKGROUND: Trauma exposure has been linked to risky sexual behavior (RSB), but few studies have examined the impact of distinct trauma types on RSB in one model or how the association with trauma and RSB may differ across race. PURPOSE: The objective of the current study was to examine the contribution of trauma exposure types to RSB-substance-related RSB and partner-related RSB identified through factor analysis-in young Black and White adult women. METHODS: We investigated the associations of multiple trauma types and RSB factor scores in participants from a general population sample of young adult female twins (n = 2,948)...
June 11, 2018: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29903442/probing-the-neuroanatomy-of-the-cerebellum-using-tractography
#18
Christophe Habas, Mario Manto
Diffusion tensor imaging (DTI) is a noninvasive neuroimaging tool assessing the organization of white-matter tracts and brain microstructure in vivo. The technique takes into account the three-dimensional (3D) direction of diffusion of water in space, the brownian movements of water being constrained by the brain microstructure. The main direction of diffusion in the brain is extracted to obtain the principal direction of axonal projection within a given voxel. Overall, the diffusion tensor is a mathematic analysis of the magnitude/directionality (anisotropy) of the movement of water molecules in 3D space...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29903436/the-neuropathology-of-the-adult-cerebellum
#19
Arnulf H Koeppen
This chapter summarizes the neuropathologic features of nonneoplastic disorders of the adult cerebellum. Gait ataxia and extremity dysmetria are clinical manifestations of diseases that interrupt the complex cerebellar circuitry between the neurons of the cerebellar cortex, the cerebellar nuclei (especially the dentate nuclei), and the inferior olivary nuclei. The cerebellum is a prominent target of several sporadic and hereditary neurodegenerative diseases, including multiple system atrophy, spinocerebellar ataxia, and Friedreich ataxia...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29902520/drugp-induced-rhabdomyolysis-atlas-dira-for-idiosyncratic-adverse-drug-reaction-management
#20
Zhining Wen, Yu Liang, Yingyi Hao, Brian Delavan, Ruili Huang, Mike Mikailov, Weida Tong, Menglong Li, Zhichao Liu
Drug-induced rhabdomyolysis (DIR) is an idiosyncratic and fatal adverse drug reaction (ADR) characterized in severe muscle injuries accompanied by multiple-organ failure. Limited knowledge regarding the pathophysiology of rhabdomyolysis is the main obstacle to developing early biomarkers and prevention strategies. Given the lack of a centralized data resource to curate, organize, and standardize widespread DIR information, here we present a Drug-Induced Rhabdomyolysis Atlas (DIRA) that provides DIR-related information, including: a classification scheme for DIR based on drug labeling information; postmarketing surveillance data of DIR; and DIR drug property information...
June 11, 2018: Drug Discovery Today
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