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https://www.readbyqxmd.com/read/28207517/a-rare-case-report-of-very-low-thyroglobulin-and-a-negative-whole-body-scan-in-a-patient-with-a-solid-variant-of-papillary-thyroid-carcinoma-with-distant-metastases
#1
Wei Li, Danyang Sun, Hui Ming, Guizhi Zhang, Jian Tan
RATIONALE: The early detection of recurrent differentiated thyroid carcinoma (DTC) cells in postsurgery DTC patients relies on the sensitivity of measuring both the level of thyroglobulin (Tg) and 131-iodine distribution on a whole-body scan (WBS). Recent studies have defined patients who subsequently have no evidence of disease as those who have a stimulated Tg level <1 ng/mL with no other radiological or clinical evidence of disease. PATIENT CONCERNS: A woman patient with solid variant papillary thyroid carcinoma (SVPTC) had undergone twice thyroidectomy with lymph node dissection and radioactive therapy...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28205670/leptin-and-ghrelin-concentration-in-hyperthyroid-cats-before-and-after-radioactive-iodine-therapy-compared-to-euthyroid-control-cats
#2
Sina Marsilio, Barbara Glanemann, Lucile Martin, Balazs Szladovits, Reto Neiger
OBJECTIVE: Leptin and ghrelin, two peptide hormones with antagonistic effects on satiety and energy balance, could be involved in the pathogenesis of weight loss and polyphagia in cats with hyperthyroidism. Leptin generally decreases appetite and increases energy expenditure, while ghrelin exerts the opposite effects. MATERIALS AND METHODS: Leptin and ghrelin were measured in 42 client owned hyperthyroid cats with a body condition score (BCS) ≤ 5/9 before (T0) and 4 weeks after radioactive iodine treatment (RAIT) (T1)...
February 16, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28203373/a-silent-skull-metastatic-follicular-thyroid-carcinoma-mimicking-as-a-benign-scalp-tumor-in-a-pregnant-woman
#3
Tsung-Chun Huang, Yu-Kai Cheng, Tsung-Wei Chen, Yung-Chang Hsu, En-Wei Liu, Hsin-Han Chen
: Thyroid cancer with cranial metastasis in a pregnant woman is very rare. In the literature, most cases are diagnosed early from neurogenic signs or symptomatic thyroid gland. Pregnancy also contributes to a hesitation toward early surgical and medical treatments. We reported a scalp tumor in a physically healthy 37-year-old pregnant female with a follicular thyroid carcinoma (FTC) with lung, bone and cranial metastasis in initial presentation. Silent neurogenic and physical examinations make an early diagnosis very challenging...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28201927/histologic-findings-and-cytological-alterations-in-thyroid-nodules-after-radioactive-iodine-treatment-for-graves-disease
#4
Siba El Hussein, Yumna Omarzai
Unlike the well-documented relation between radiation to the neck and development of papillary thyroid carcinoma, a causal association between radioactive iodine treatment for Graves' disease and development of thyroid malignancy is less defined. However, patients with a background of thyroid dysfunction presenting with clinically palpable thyroid nodules are followed more closely than the average population, and fine needle aspiration is recommended in such circumstances. Cytological examination of aspirates, and histologic examination of tissue provided from patients with a known history of Graves' disease, managed by radioactive iodine therapy can create a diagnostic dilemma, as the distinction between radiation effect and a malignant primary thyroid neoplasm can be very challenging...
February 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28192678/assaying-the-stability-and-inactivation-of-aav-serotype-1-vectors
#5
Douglas B Howard, Brandon K Harvey
Adeno-associated virus (AAV) vectors are a commonplace tool for gene delivery ranging from cell culture to human gene therapy. One feature that makes AAV a desirable vector is its stability, in regard to both the duration of transgene expression and retention of infectivity as a viral particle. This study examined the stability of AAV serotype 1 (AAV1) vectors under different conditions. First, transducibility after storage at 4°C decreased 20% over 7 weeks. Over 10 freeze-thaw cycles, the resulting transduction efficiency became variable at 60-120% of a single thaw...
February 2017: Human Gene Therapy Methods
https://www.readbyqxmd.com/read/28188808/characterization-of-a-novel-intrinsically-radiopaque-drug-eluting-bead-for-image-guided-therapy-dc-bead-lumi%C3%A2
#6
Koorosh Ashrafi, Yiqing Tang, Hugh Britton, Orianne Domenge, Delphine Blino, Andrew J Bushby, Kseniya Shuturminska, Mark den Hartog, Alessandro Radaelli, Ayele H Negussie, Andrew S Mikhail, David L Woods, Venkatesh Krishnasamy, Elliot B Levy, Bradford J Wood, Sean L Willis, Matthew R Dreher, Andrew L Lewis
We have developed a straightforward and efficient method of introducing radiopacity into Polyvinyl alcohol (PVA)-2-Acrylamido-2-methylpropane sulfonic acid (AMPS) hydrogel beads (DC Bead™) that are currently used in the clinic to treat liver malignancies. Coupling of 2,3,5-triiodobenzaldehyde to the PVA backbone of pre-formed beads yields a uniformly distributed level of iodine attached throughout the bead structure (~150mg/mL) which is sufficient to be imaged under standard fluoroscopy and computed tomography (CT) imaging modalities used in treatment procedures (DC Bead LUMI™)...
February 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28169369/fast-and-quantitative-t1%C3%AF-weighted-dynamic-glucose-enhanced-mri
#7
Patrick Schuenke, Daniel Paech, Christina Koehler, Johannes Windschuh, Peter Bachert, Mark E Ladd, Heinz-Peter Schlemmer, Alexander Radbruch, Moritz Zaiss
Common medical imaging techniques usually employ contrast agents that are chemically labeled, e.g. with radioisotopes in the case of PET, iodine in the case of CT or paramagnetic metals in the case of MRI to visualize the heterogeneity of the tumor microenvironment. Recently, it was shown that natural unlabeled D-glucose can be used as a nontoxic biodegradable contrast agent in Chemical Exchange sensitive Spin-Lock (CESL) magnetic resonance imaging (MRI) to detect the glucose uptake and potentially the metabolism of tumors...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28161927/optimal-duration-for-the-use-of-0-5-levofloxacineye-drops-before-vitreoretinal-surgery
#8
Xiaoxin Li, Xiaoling Liang, Luosheng Tang, Junjun Zhang, Lijun Shen, Guanfang Su, Xiaorong Li
PURPOSE: To investigate various regimens of prophylactic antibiotic therapy for vitreoretinal surgery. DESIGN: This study compared different prophylactic therapies with 0.5% levofloxacin eye drops. METHODS: Two hundred nine patients from 7 hospitals scheduled to undergo vitreoretinal surgery were randomized into 3 groups to receive 0.5% levofloxacin eye drops for 1 day (6 times/d), 2 days (3 times/d), or 3 days (3 times/d) before surgery (groups 1D, 2D, and 3D, respectively)...
January 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28151897/preparation-for-radioactive-iodine-therapy-is-not-a-risk-factor-for-the-development-of-hyponatremia-in-thyroid-cancer-patients
#9
Jahae Kim, Sang-Geon Cho, Sae-Ryung Kang, Seong Young Kwon, Dong-Hyeok Cho, Jin-Seong Cho, Ho-Chun Song
The aim of this study was to evaluate whether the preparation for radioactive iodine (RAI) therapy by thyroid hormone withdrawal (THW) or a low-iodine diet (LID) can be risk factors for the development of hyponatremia in patients with differentiated thyroid cancer after thyroidectomy.We retrospectively reviewed the medical records and laboratory findings of 326 patients who underwent preparation for RAI therapy after thyroidectomy from 2012 to 2014. Demographic and clinical variables including the method of thyrotropin stimulation and duration of LID were assessed...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28151849/survival-of-patients-with-advanced-pancreatic-cancer-after-iodine125-seeds-implantation-brachytherapy-a-meta-analysis
#10
Quanli Han, Muhong Deng, Yao Lv, Guanghai Dai
BACKGROUND: Brachytherapy with iodine-labeled seeds (I-seeds) implantation is increasingly being used to treat tumors because of its positional precision, minimal invasion, least damage to noncancerous tissue due to slow and continuous release of radioactivity and facilitation with modern medical imaging technologies. This study evaluates the survival and pain relief outcomes of the I-seeds implantation brachytherapy in advanced pancreatic cancer patients. METHODS: Literature search was carried out in multiple electronic databases (Google Scholar, Embase, Medline/PubMed, and Ovid SP) and studies reporting I seeds implantation brachytherapy in pancreatic cancer patients with unresectable tumor were selected by following predetermined eligibility criteria...
February 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28141684/treatment-and-surveillance-of-advanced-metastatic-iodine-resistant-differentiated-thyroid-cancer
#11
Eiman Y Ibrahim, Naifa L Busaidy
PURPOSE OF REVIEW: This review will focus on the management and treatment of metastatic thyroid cancer that is radioactive iodine refractory and review the new drugs and their mechanism of actions as well as their adverse events. RECENT FINDINGS: Until recently, there were no efficacious therapeutic modalities for these patients. With advancement in knowledge and research of the molecular aberrations and oncogenic mutations in thyroid cancer as well as further understanding the role of angiogenesis in tumor growth molecular pathogenesis, novel targeted therapies are available for these patients...
March 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28136139/outcome-of-large-noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-niftp
#12
Bin Xu, Giovanni Tallini, Theresa Scognamiglio, Benjamin R Roman, R Michael Tuttle, Ronald Ghossein
BACKGROUND: In 2016, encapsulated papillary thyroid carcinoma, follicular variant without invasion was renamed noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in order to reduce overtreatment of this indolent tumor. However, many endocrinologists remain uneasy about managing large (≥ 4 cm) NIFTP conservatively without radioactive iodine (RAI) therapy. The objectives of this study are to characterize the clinicopathologic characteristics and outcome of large NIFTP in order to assist therapeutic decision making...
January 30, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28124815/dual-fluorescent-and-isotopic-labelled-self-assembling-vancomycin-for-in%C3%A2-vivo-imaging-of-bacterial-infections
#13
Cuihong Yang, Chunhua Ren, Jie Zhou, Jinjian Liu, Yumin Zhang, Fan Huang, Dan Ding, Bing Xu, Jianfeng Liu
The increase of bacterial resistance demands rapid and accurate diagnosis of bacterial infections. Biosurface-induced supramolecular assembly for diagnosis and therapy has received little attention in detecting bacterial infections. Herein we present a dual fluorescent-nuclear probe based on self-assembly of vancomycin (Van) on Gram-positive bacteria for imaging bacterial infection. A Van- and rhodamine-modified peptide derivative (Rho-FF-Van), as the imaging agent, binds to the terminal peptide of the methicillin-resistant staphylococcus aureus (MRSA) and self-assembles to form nanoaggregates on the surface of MRSA...
January 26, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28124642/the-effects-of-radioactive-iodine-therapy-on-olfactory-function
#14
Bilici Suat, Edizer Deniz Tuna, Yigit Ozgur, Yildiz Muhammet, Cermik Tevfik Fikret
PURPOSE: To determine the possible adverse effects of radioactive iodine (RAI) treatment on the olfactory functions of patients with differentiated thyroid carcinoma. MATERIALS AND METHODS: This prospective clinical study included 63 Turkish patients who had been diagnosed with papillary thyroid carcinoma only to ensure homogeneity. The Connecticut Chemosensory Clinical Research Center olfactory test was administered at 1 week before treatment and at the third week and the first year after treatment...
November 1, 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28124050/iodinated-cyanine-dyes-a-new-class-of-sensitisers-for-use-in-nir-activated-photodynamic-therapy-pdt
#15
Jordan Atchison, Sukanta Kamila, Heather Nesbitt, Kieran A Logan, Dean M Nicholas, Colin Fowley, James Davis, Bridgeen Callan, Anthony P McHale, John F Callan
A new class of iodinated cyanine dyes have been prepared for use in NIR excited photodynamic therapy (PDT) and demonstrated improved efficacy in two pancreatic cell lines as well as excellent tumour control in a murine model of the disease.
January 26, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28109633/the-american-college-of-radiology-and-the-american-brachytherapy-society-practice-parameter-for-the-performance-of-low-dose-rate-brachytherapy
#16
Akila N Viswanathan, Beth A Erickson, Geoffrey S Ibbott, William Small, Patricia J Eifel
Brachytherapy is the use of radionuclides to treat malignancies or benign conditions by means of a radiation source placed close to or into the tumor or treatment site. This practice parameter refers only to the use of radionuclide brachytherapy. Brachytherapy alone or combined with external beam therapy plays an important role in the management and treatment of patients with cancer. Low-dose-rate (LDR) brachytherapy has traditionally been used for treating prostate, head and neck, breast, cervical, and endometrial cancers as well as obstructive bile duct, esophageal, or bronchial lesions...
January 2017: Brachytherapy
https://www.readbyqxmd.com/read/28105610/antithyroid-drug-induced-agranulocytosis-state-of-the-art-on-diagnosis-and-management
#17
Nuno Vicente, Luís Cardoso, Luísa Barros, Francisco Carrilho
Agranulocytosis is a rare but serious complication of antithyroid drug therapy, and an up-to-date understanding of this topic is important. Both direct toxicity and immune-mediated responses have been described as possible mechanisms. Some major susceptibility loci have recently been identified, which may lead the diagnosis of agranulocytosis into a genomic era. Onset is acute and patients present with symptoms and signs of infection together with high fever. Clinical suspicion is pivotal and should prompt blood sampling...
January 19, 2017: Drugs in R&D
https://www.readbyqxmd.com/read/28102954/dosimetric-impact-of-lipiodol-in-stereotactic-body-radiation-therapy-on-liver-after-trans-arterial-chemoembolization
#18
Daisuke Kawahara, Shuichi Ozawa, Akito Saito, Teiji Nishio, Tomoki Kimura, Tatsuhiko Suzuki, Kazunari Hioki, Takeo Nakashima, Yoshimi Ohno, Yuji Murakami, Yasushi Nagata
PURPOSE: Stereotactic body radiation therapy (SBRT) combining trans-arterial chemoembolization (TACE) with Lipiodol is expected to improve local control. This study is aimed to estimate the dose enhancement in Lipiodol's proximity and to evaluate the dose calculation accuracy of the Acuros XB (AXB) algorithm and anisotropic analytical algorithm (AAA) in the Eclipse treatment planning system (TPS) (ver. 11, Varian Medical Systems, Palo Alto, USA), compared with that of the Monte Carlo (MC) calculation (using BEAMnrc/DOSXYZnrc code) for a virtual phantom and a treatment plan for liver SBRT after TACE...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28101490/periodic-granulocyte-count-measuring-is-useful-for-detecting-asymptomatic-agranulocytosis-in-antithyroid-drug-treated-patients-with-graves-disease
#19
Hirotoshi Nakamura, Akane Ide, Takumi Kudo, Eijun Nishihara, Mitsuru Ito, Akira Miyauchi
OBJECTIVE: Finding agranulocytosis (AG) at an early stage is important to improve outcome, but periodic granulocyte count monitoring is not generally recommended for patients with Graves' disease, because AG develops suddenly. METHOD: At the Kuma Hospital, Graves' patients under antithyroid drug (ATD) treatment in an outpatient clinic have a granulocyte count examination during each visit, and if it is <1,000/μl, a warning is immediately sent to the patient's physician...
December 2016: European Thyroid Journal
https://www.readbyqxmd.com/read/28099584/iodine-131-treatment-of-thyroid-cancer-cells-leads-to-suppression-of-cell-proliferation-followed-by-induction-of-cell-apoptosis-and-cell-cycle-arrest-by-regulation-of-b-cell-translocation-gene-2-mediated-jnk-nf-%C3%AE%C2%BAb-pathways
#20
L M Zhao, A X Pang
Iodine-131 (131I) is widely used for the treatment of thyroid-related diseases. This study aimed to investigate the expression of p53 and BTG2 genes following 131I therapy in thyroid cancer cell line SW579 and the possible underlying mechanism. SW579 human thyroid squamous carcinoma cells were cultured and treated with 131I. They were then assessed for 131I uptake, cell viability, apoptosis, cell cycle arrest, p53 expression, and BTG2 gene expression. SW579 cells were transfected with BTG2 siRNA, p53 siRNA and siNC and were then examined for the same aforementioned parameters...
January 16, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
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