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https://www.readbyqxmd.com/read/27911450/uveal-melanoma-relatively-rare-but-deadly-cancer
#1
REVIEW
S Kaliki, C L Shields
Although it is a relatively rare disease, primarily found in the Caucasian population, uveal melanoma is the most common primary intraocular tumor in adults with a mean age-adjusted incidence of 5.1 cases per million per year. Tumors are located either in iris (4%), ciliary body (6%), or choroid (90%). The host susceptibility factors for uveal melanoma include fair skin, light eye color, inability to tan, ocular or oculodermal melanocytosis, cutaneous or iris or choroidal nevus, and BRCA1-associated protein 1 mutation...
December 2, 2016: Eye
https://www.readbyqxmd.com/read/27869547/dynamic-risk-stratification-for-predicting-recurrence-in-patients-with-differentiated-thyroid-cancer-treated-without-radioactive-iodine-remnant-ablation-therapy
#2
Suyeon Park, Won Gu Kim, Eyun Song, Hye-Seon Oh, Mijin Kim, Hyemi Kwon, MinJi Jeon, Tae Yong Kim, YoungKee Shong, Won Bae Kim
BACKGROUND: Increased incidence of small differentiated thyroid cancer (DTC) has emphasized the need for risk stratification and individualized disease management for these low risk DTCs. The aim was to validate a new dynamic risk stratification (DRS) system for prediction of structural recurrent/persistent disease in patients with DTC treated without radioactive iodine (RAI) remnant ablation therapy. METHODS: This historical cohort study included 357 patients with DTC treated with lobectomy or total thyroidectomy without RAI therapy...
November 21, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27866718/mutational-analysis-of-metastatic-lymph-nodes-from-papillary-thyroid-carcinoma-in-adult-and-pediatric-patients
#3
Alexander L Shifrin, Michele Fischer, Trevor Paul, Brian Erler, Katherine Gheysens, Prachi Baodhankar, Joanna W Song-Yang, Samantha Taylor, Venkata Arun Timmaraju, Arthur Topilow, Alidad Mireskandari, Gyanendra Kumar
BACKGROUND: Limited data are available on the analysis of somatic mutations in metastatic lymph nodes in adult and pediatric patients with papillary thyroid carcinomas. METHODS: A total of 92, microdissected, formalin-fixed, paraffin-embedded tissue specimens from 39 patients were analyzed for the presence of somatic mutations utilizing the ThyGenX next-generation sequencing test. RESULTS: Somatic mutations were detected in 67% of papillary thyroid carcinoma specimens...
November 17, 2016: Surgery
https://www.readbyqxmd.com/read/27863789/comparative-analysis-of-radioactive-iodine-versus-thyroidectomy-for-definitive-treatment-of-graves-disease
#4
Vincent T Wu, Allison W Lorenzen, Anna C Beck, Vincent J Reid, Sonia L Sugg, James R Howe, Janet H Pollard, Geeta Lal, Ronald J Weigel
BACKGROUND: Management of Graves disease includes antithyroid drugs, (131)I therapy, or thyroidectomy. Our aim was to review our institutional experience with definitive treatments for Graves disease. METHODS: This was a retrospective review of patients undergoing (131)I therapy (n = 295) or thyroidectomy (n = 103) for Graves disease (2003-2015). Demographic, clinical, pathology, and outcome data were collected from institutional databases. RESULTS: (131)I therapy patients were older (39...
November 15, 2016: Surgery
https://www.readbyqxmd.com/read/27859922/cadexomer-iodine-provides-superior-efficacy-against-bacterial-wound-biofilms-in-vitro-and-in-vivo
#5
Daniel J Fitzgerald, Paul J Renick, Emma C Forrest, Shannon P Tetens, David N Earnest, Jillian McMillan, Brett M Kiedaisch, Lei Shi, Eric D Roche
Examination of clinical samples indicates bacterial biofilms are present in the majority of chronic wounds, and substantial evidence suggests biofilms contribute significantly to delayed healing. Bacteria in biofilms are highly tolerant of antimicrobials, and little data exist to guide the choice of anti-biofilm wound therapy. Cadexomer Iodine (CI) was recently reported to have superior efficacy compared to diverse wound dressings against Pseudomonas aeruginosa biofilms in an ex vivo model. In the current study, the strong performance of CI versus P...
November 17, 2016: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/27856930/effects-of-thyroid-hormone-withdrawal-on-metabolic-and-cardiovascular-parameters-during-radioactive-iodine-therapy-in-differentiated-thyroid-cancer
#6
Jee Hyun An, Kee-Ho Song, Dong-Lim Kim, Suk Kyeong Kim
OBJECTIVE: To investigate the cardiometabolic effects of a severe hypothyroid state induced by withdrawal of thyroid hormone replacement before radioactive iodine therapy. METHODS: Patients with thyroid cancer who were scheduled to receive radioactive iodine ablation were enrolled. Cardiometabolic parameters were measured using blood samples taken immediately before levothyroxine withdrawal, 4 weeks following withdrawal (on radiotherapy day), and 4 weeks following reinstitution of levothyroxine...
November 17, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27855968/application-of-the-new-american-thyroid-association-guidelines-leads-to-a-substantial-rate-of-completion-total-thyroidectomy-to-enable-adjuvant-radioactive-iodine
#7
Wouter P Kluijfhout, Jesse D Pasternak, Frederick T Drake, Toni Beninato, Wen T Shen, Jessica E Gosnell, Insoo Suh, Liu C, Quan-Yang Duh
BACKGROUND: The recently published 2015 American Thyroid Association guidelines recognize lobectomy as a viable alternative for low-risk cancers and advise more conservative use of radioactive iodine. Some factors indicating adjuvant treatment with radioactive iodine (and therefore completion total thyroidectomy), however, only can be found upon pathologic investigation. METHODS: We performed a retrospective analysis including patients with American Thyroid Association low- and low-to-intermediate risk well-differentiated thyroid cancer 1-4 cm...
November 14, 2016: Surgery
https://www.readbyqxmd.com/read/27853381/h%C3%A3-rthle-cell-carcinoma-current-perspectives
#8
REVIEW
Sara Ahmadi, Michael Stang, Xiaoyin Sara Jiang, Julie Ann Sosa
Hürthle cell carcinoma (HCC) can present either as a minimally invasive or as a widely invasive tumor. HCC generally has a more aggressive clinical behavior compared with the other differentiated thyroid cancers, and it is associated with a higher rate of distant metastases. Minimally invasive HCC demonstrates much less aggressive behavior; lesions <4 cm can be treated with thyroid lobectomy alone, and without radioactive iodine (RAI). HCC has been observed to be less iodine-avid compared with other differentiated thyroid cancers; however, recent data have demonstrated improved survival with RAI use in patients with HCC >2 cm and those with nodal and distant metastases...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27853074/outpatient-131-i-treatment-for-a-patient-with-graves-disease-receiving-hemodialysis
#9
Miho Suzuki, Jaeduk Yoshimura Noh, Kiminori Sugino, Koichi Ito
A patient presented with hyperthyroidism and end-stage renal disease requiring hemodialysis that was difficult to control despite increased dosages of anti-thyroid drugs. The condition could finally be controlled by (131)I radioactive iodine therapy (RIT) and hemodialysis provided under a hospital-linkage system. During three hemodialysis sessions after the oral administration of (131)I, we measured the radioactivity released from the patient and the radioactivity of the devices/tools used. The radioactivity of the devices/tools was managed by allowing the isotope to decay into non-radioactive elements...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27846003/imaging-of-prostate-specific-membrane-antigen-expression-in-metastatic-differentiated-thyroid-cancer-using-68ga-hbed-cc-psma-pet-ct
#10
Susanne Lütje, Benedikt Gomez, Joseph Cohnen, Lale Umutlu, Martin Gotthardt, Thorsten D Poeppel, Andreas Bockisch, Sandra Rosenbaum-Krumme
PURPOSE: The prostate-specific membrane antigen (PSMA) was shown to be overexpressed on the neovasculature of several malignancies. Here, the role of Ga-HBED-CC-PSMA PET/CT for the detection of PSMA expression in patients with metastasized differentiated thyroid cancer (DTC) was evaluated. METHODS: Six patients with iodine-negative and F-FDG-positive metastasized DTC (mean TG, 1616 ng/mL) received 71-93 MBq of the Ga-labeled PSMA ligand and underwent PET/CT at 62 ± 7 minutes p...
January 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27824959/risk-factors-and-stratification-for-recurrence-of-patients-with-differentiated-thyroid-cancer-elevated-thyroglobulin-and-negative-i-131-whole-body-scan-by-restaging-18-f-fdg-pet-ct
#11
Kursat Okuyucu, Semra Ince, Engin Alagoz, Ozdes Emer, Huseyin San, Elif Balkan, Aslı Ayan, Coskun Meric, Cem Haymana, Cengizhan Acıkel, Bengul Gunalp, Alper Ozgur Karacalioglu, Nuri Arslan
OBJECTIVE: In nearly 20%-30% of patients with differentiated thyroid carcinoma (DTC) relapse and 7% of them die during the next 10 years after initial diagnosis. In 10%-30% of patients with DTC after ablation therapy during the follow-up show a negative iodine-131 ((131)I) whole-body screening test ((131)I WBS) and increased serum thyroglobulin (Tg) level. Loss of ability of DTC metastatic lesions to trap (131)I is associated with pure survival and often aggressive disease. Several studies have shown that in DTC cases non trapping (131)I, fluorine-18-fluorodeoxyglucose positron emission tomography ((18)F-FDG PET) can detect recurrence or metastases with high sensitivity (80%-90%)...
November 8, 2016: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27813621/incidental-thyroid-99mtc-mdp-uptake-in-a-patient-affected-by-differentiated-thyroid-cancer
#12
Domenico Albano, Gian Carlo Magri, Giorgio Treglia, Francesco Bertagna
We report a case of incidental uptake of 99mTc-methylene diphosphonate in the thyroid in a 62-year-old female with a history of breast cancer treated with quadrantectomy, chemotherapy and radiotherapy, who underwent total-body-bone scintigraphy during follow up. Planar scintigraphy was followed by neck SPECT-CT that demonstrated an area of increased tracer uptake in the neck at the left lobe of the thyroid. Neck ultrasonography showed a nodule corresponding to SPECT-CT finding and the ultrasound-guided fine needle aspiration documented the presence of papillary carcinoma...
2016: Nuclear Medicine Review. Central & Eastern Europe
https://www.readbyqxmd.com/read/27809936/impact-of-combined-fdg-pet-ct-and-mri-on-the-detection-of-local-recurrence-and-nodal-metastases-in-thyroid-cancer
#13
Johann-Martin Hempel, Roman Kloeckner, Sandra Krick, Daniel Pinto Dos Santos, Simin Schadmand-Fischer, Patrick Boeßert, Sotirios Bisdas, Matthias M Weber, Christian Fottner, Thomas J Musholt, Mathias Schreckenberger, Matthias Miederer
BACKGROUND: Suspected recurrence of thyroid carcinoma is a diagnostic challenge when findings of both a radio iodine whole body scan and ultrasound are negative. PET/CT and MRI have shown to be feasible for detection of recurrent disease. However, the added value of a consensus reading by the radiologist and the nuclear medicine physician, which has been deemed to be helpful in clinical routines, has not been investigated. This study aimed to investigate the impact of combined FDG-PET/ldCT and MRI on detection of locally recurrent TC and nodal metastases in high-risk patients with special focus on the value of the multidisciplinary consensus reading...
November 3, 2016: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/27804925/multiple-energy-synchrotron-biomedical-imaging-system
#14
B Bassey, M Martinson, N Samadi, G Belev, C Karanfil, P Qi, D Chapman
A multiple energy imaging system that can extract multiple endogenous or induced contrast materials as well as water and bone images would be ideal for imaging of biological subjects. The continuous spectrum available from synchrotron light facilities provides a nearly perfect source for multiple energy x-ray imaging. A novel multiple energy x-ray imaging system, which prepares a horizontally focused polychromatic x-ray beam, has been developed at the BioMedical Imaging and Therapy bend magnet beamline at the Canadian Light Source...
November 2, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27804856/a-papillary-thyroid-carcinoma-in-pediatric-age-an-example-of-a-rare-tumour-managed-within-a-cooperative-comprehensive-project
#15
Claudio Spinelli, Maura Massimino, Giovanna Sironi, Andrea Ferrari, Marta Podda, Stefano Chiaravalli
Though rare in childhood, thyroid cancers represent the most frequent tumours of endocrine glands in childhood and adolescence. Papillary thyroid carcinoma is a non-medullary, follicular-derived differentiated tumour of the thyroid. There is still controversy concerning the therapeutic approach of PTCs in the paediatric population; regarding which should be the extent of the surgical approach, and the need for radioactive iodine (RAI) therapy. The cooperative TREP project (Tumori Rari in Età Pediatrica [Rare Tumours in Paediatric Age]) was launched in Italy in 2000 (under the patronage of AIEOP - Associazione Italiana Ematologia Oncologia Pediatrica) with a view to improving both research the clinical management on the less common paediatric cancers...
October 31, 2016: Current Pediatric Reviews
https://www.readbyqxmd.com/read/27801741/extrathyroidal-radioiodine-accumulation-in-a-fibroadenoma-of-the-breast
#16
Myoung Hyoun Kim, Hun Soo Kim, Soon-Ah Park
A 45-year-old woman with a differentiated thyroid carcinoma received adjuvant radioiodine therapy following total thyroidectomy and left modified radical neck dissection. A posttherapy planar radioiodine scan showed multifocal uptake in the thyroid bed and left chest. SPECT/CT revealed a fibroadenoma in the left breast. Six months later, an I scan showed no iodine avidity in the breast fibroadenoma, whereas ultrasonography showed no significant change in the size of the fibroadenoma. Altered radioiodine uptake of a breast fibroadenoma can be observed on follow-up scans after cytotoxic radioiodide treatment in patients with differentiated thyroid carcinoma...
October 31, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27794246/incidental-papillary-thyroid-carcinoma-in-thyroglossal-duct-cyst-case-report
#17
Ana Karen Lira Medina, Eliseo Fernandez Berdeal, Ernesto Bernal Cisneros, Rebeca Betancourt Galindo, Pamela Frigerio
INTRODUCTION: The thyroglossal cyst is found in 7% of the population and the incidental papillary thyroid carcinoma in thyroglossal cyst is a rare entity with an incidence 1 to 2%. The clinical presentation is indistinguishable from a benign lesion and the histopathological postoperative study defines the diagnosis. Papillary carcinomas have favorable prognosis and cervical or distant metastases are rare. There is now a consensus on the indication of total thyroidectomy, radioablation with iodine and/or suppressive therapy with levothyroxine after being removed surgically [1-3] (Patrucco et al...
October 15, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27789751/teaching-case-nuclear-imaging-in-metastatic-paraganglioma
#18
Rohit Kedia, Neil Hansen, Whitney Goldner
Paragangliomas associated with succinate dehydrogenase subunit D (SDHD) mutations can occasionally result in distant metastasis. Diagnosis can be difficult, and nuclear imaging is used to further evaluate. Not all tumors are alike and may have different nuclear avidity. We present a case of metastatic SDHD paraganglioma with a negative Iodine-123-Meta-Iodobenzylguanidine ((123)I-MIBG) and a positive 111 Indium-labelled octreotide scintigraphy ((111)In-OCT). This presents an opportunity for a novel therapeutic approach for metastatic paraganglioma using targeted peptide receptor radionuclide therapy (PRRT)...
October 27, 2016: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/27758032/temporal-analysis-of-thyroid-cancer-management-in-a-melbourne-tertiary-centre
#19
James C Lee, Paula Chang, Simon Grodski, Meei Yeung, William Johnson, Jonathan Serpell
BACKGROUND: The American Thyroid Association (ATA) management guidelines for thyroid cancer were revised in 2009. The aim of this study was to determine if management of thyroid cancer in our institution has changed in accordance with the introduction of the revised ATA guidelines (ATA(2009) ), and to compare the characteristics and management of thyroid cancer in a Melbourne endocrine surgery unit over a 7-year period. METHODS: All patients treated by the Monash University Endocrine Surgery Unit for thyroid cancer between 2007 and 2013 were divided into two groups - the pre-ATA(2009) group (2007-2010) and the post-ATA(2009) group (2011-2013)...
October 18, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27751976/aggressive-disease-course-of-papillary-thyroid-carcinoma-with-focal-undifferentiated-component-a-case-report
#20
Saima Riaz, Humayun Bashir, Aamna Hassan, Sajid Mushtaq, Arif Jamshed, Ahmad Murtaza
We report an aggressive papillary thyroid carcinoma (PTC) with focal undifferentiated component in a 32-year-old female. She had limited disease confined within the thyroid gland at diagnosis. Within 12 months of thyroidectomy and radioiodine ablation, thyroglobulin (Tg) levels were elevated. Second radioiodine ablative dose was given, however, stimulated Tg levels showed an upward trend with negative iodine scan within 12 months. An 18F fludeoxyglucose-avid solitary pulmonary nodule that was detected on positron emission tomography/computed tomography scan was resected followed by empiric radioiodine therapy...
October 5, 2016: Molecular Imaging and Radionuclide Therapy
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