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https://www.readbyqxmd.com/read/28441828/-clinical-analysis-of-seven-cases-of-pulmonary-malignant-tumors-in-children
#1
D Xu, Z M Chen, W Z Gu, Y S Wang, M X Huang, L F Tang, Y Y Zhang, Y Jiang
Objective: To understand the clinical manifestation, imaging characteristics and outcomes of pulmonary malignant tumors in children. Method: We retrospectively collected information about seven cases of pulmonary malignant tumors in children in our hospital from Jan 2010 to Dec 2016. The information included clinical manifestation, imaging characteristics, pathologic results, and treatment. Result: (1) All the seven patients firstly visited pediatric internal medicine departments. Symptoms included cough (n=6), dyspnea (n=4), fever (n=2), anorexia (n=2), chest tightness (n=1), chest pain (n=1), lameness (n=1), abdominal distension and constipation (n=1)...
April 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/28435761/dual-energy-ct-in-head-and-neck-imaging
#2
REVIEW
Elise D Roele, Veronique C M L Timmer, Lauretta A A Vaassen, Anna M J L van Kroonenburgh, A A Postma
PURPOSE OF REVIEW: To explain the technique of Dual-energy CT (DECT) and highlight its applications and advantages in head and neck radiology. RECENT FINDINGS: Using DECT, additional datasets can be created next to conventional images. In head and neck radiology, three material decomposition algorithms can be used for improved lesion detection and delineation of the tumor. Iodine concentration measurements can aid in differentiating malignant from nonmalignant lymph nodes and benign posttreatment changes from tumor recurrence...
2017: Current Radiology Reports
https://www.readbyqxmd.com/read/28429876/iodine-131-meta-iodobenzylguanidine-therapy-for-patients-with-newly-diagnosed-high-risk-neuroblastoma
#3
REVIEW
Kathelijne Cjm Kraal, Elvira C van Dalen, Godelieve Am Tytgat, Berthe Lf Van Eck-Smit
BACKGROUND: Patients with newly diagnosed high-risk (HR) neuroblastoma (NBL) still have a poor outcome, despite multi-modality intensive therapy. This poor outcome necessitates the search for new therapies, such as treatment with (131)I-meta-iodobenzylguanidine ((131)I-MIBG). OBJECTIVES: To assess the efficacy and adverse effects of (131)I-MIBG therapy in patients with newly diagnosed HR NBL. SEARCH METHODS: We searched the following electronic databases: the Cochrane Central Register of Controlled Trials (CENTRAL; the Cochrane Library 2016, Issue 3), MEDLINE (PubMed) (1945 to 25 April 2016) and Embase (Ovid) (1980 to 25 April 2016)...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28428282/whither-radioimmunotherapy-to-be-or-not-to-be
#4
Damian J Green, Oliver W Press
Therapy of cancer with radiolabeled monoclonal antibodies has produced impressive results in preclinical experiments and in clinical trials conducted in radiosensitive malignancies, particularly B-cell lymphomas. Two "first-generation," directly radiolabeled anti-CD20 antibodies, (131)iodine-tositumomab and (90)yttrium-ibritumomab tiuxetan, were FDA-approved more than a decade ago but have been little utilized because of a variety of medical, financial, and logistic obstacles. Newer technologies employing multistep "pretargeting" methods, particularly those utilizing bispecific antibodies, have greatly enhanced the therapeutic efficacy of radioimmunotherapy and diminished its toxicities...
April 20, 2017: Cancer Research
https://www.readbyqxmd.com/read/28423638/her-inhibitor-promotes-braf-mek-inhibitor-induced-redifferentiation-in-papillary-thyroid-cancer-harboring-brafv600e
#5
Lingxiao Cheng, Yuchen Jin, Min Liu, Maomei Ruan, Libo Chen
Redifferentiation therapy with BRAF/MEK inhibitors to facilitate treatment with radioiodine represents a good choice for radioiodine-refractory differentiated thyroid carcinoma, but recent initial clinical outcomes were modest. MAPK rebound caused by BRAF/MEK inhibitors-induced activation of HER2/HER3 is a resistance mechanism, and combination with HER inhibitor to prevent MAPK rebound may sensitize BRAFV600E-mutant thyroid cancer cells to redifferentiation therapy. To evaluate if inhibiting both BRAF/MEK and HER can produce stronger redifferetiation effect, we tested the effects of BRAF/MEK inhibitor dabrafenib/selumetinib alone or in combination with HER inhibitor lapatinib on the expression and function of iodine- and glucose-handling genes in BRAFV600E-positive BCPAP and K1 cells, using BHP 2-7 cells harboring RET/PTC1 rearrangement as control...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28419319/influence-of-concentration-nanoparticle-size-beam-energy-and-material-on-dose-enhancement-in-radiation-therapy
#6
Chulhwan Hwang, Ja Mee Kim, JungHoon Kim
The purpose of this study was to analyse the effects of the type, concentration, and nanoparticle diameter of dose enhancement materials on the dose enhancement of low- and high-energy megavoltage (MV) X-rays acquired from a medical linear accelerator using Monte Carlo simulation. Monte Carlo simulation was performed with the Monte Carlo N-Particle Transport (MCNPX) code, using the energy spectrum of the linear accelerator and a mathematical Snyder head phantom. A 5-cm-diameter virtual tumour was defined in the centre of the phantom...
April 17, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28415430/x-ray-visible-and-doxorubicin-loaded-beads-based-on-inherently-radiopaque-poly-lactic-acid-polyurethane-for-chemoembolization-therapy
#7
Lin Sang, Dongdong Luo, Zhiyong Wei, Min Qi
The aim of current study was to develop drug-loaded polymeric beads with intrinsic X-ray visibility as embolic agents, targeting for noninvasive intraoperative location and postoperative examination during chemoembolization therapy. To endow polymer with inherent radiopacity, 4,4'-isopropylidinedi-(2,6-diiodophenol) (IBPA) was firstly synthesized and employed as a contrast agent, and then a set of radiopaque iodinated poly(lactic acid)-polyurethanes (I-PLAUs) via chain extender method were synthesized and characterized...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28414279/short-term-effects-of-radioiodine-therapy-on-auditory-function
#8
Deniz Tuna Edizer, Suat Bilici, Muhammet Yıldız, Özgür Yiğit, Tevfik Fikret Çermik
OBJECTIVE: Radioiodine therapy (RIT) is frequently utilized as an adjunctive treatment option for differentiated thyroid carcinoma following surgical intervention. The side effects of RIT are considered to emerge as a result of radioiodine accumulation in non-thyroidal tissues capable of iodine uptake. We aimed to evaluate the effects of RIT on auditory function. MATERIALS AND METHODS: Patients who had undergone total thyroidectomy and diagnosed to have differentiated thyroid carcinoma were analyzed...
April 17, 2017: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/28405805/a-rotating-cerium-anode-x-ray-system-allows-visualization-of-intramural-coronary-vessels-after-cardiac-stem-cell-therapy-for-myocardial-infarction
#9
Chiharu Tanaka, Toru Hosoda, Yoshimori Ikeya, Yoshiro Shinozaki, Kikue Todoroki, Toru Shizuma, Takashi Shiraishi, Naoto Fukuyama, Toshihiko Ueda, Hidezo Mori
Conventional angiography is insufficient for evaluating the therapeutic effect of cardiac regeneration therapy. A microangiographic X-ray system using a cerium anode was developed. Cerium has a characteristic X-ray with a peak at 34.6 keV, which allows visualization of tiny amounts of iodine. The performance of the cerium anode X-ray system was evaluated in two excised normal canine hearts and in excised ischemic canine hearts treated with c-kit-positive cardiac stem cells (5 canines) or without cells (5 control canines)...
April 12, 2017: Journal of Physiological Sciences: JPS
https://www.readbyqxmd.com/read/28402558/effect-of-cadexomer-iodine-on-the-microbial-load-and-diversity-of-chronic-non-healing-diabetic-foot-ulcers-complicated-by-biofilm-in-vivo
#10
M Malone, K Johani, S O Jensen, I B Gosbell, H G Dickson, S McLennan, H Hu, K Vickery
Objectives: The performance of cadexomer iodine was determined against microbial populations from chronic non-healing diabetic foot ulcers (DFUs) complicated by biofilm in vivo , using molecular, microscopy and zymography methods. Methods: Chronic non-healing DFUs due to suspected biofilm involvement were eligible for enrolment. DNA sequencing and real-time quantitative PCR was used to determine the microbial load and diversity of tissue punch biopsies obtained pre- and post-treatment...
April 10, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28398380/-amiodarone-induced-thyrotoxicosis
#11
Fausto Bogazzi, Luca Tomisti, Vitantonio Di Bello, Enio Martino
Amiodarone-induced thyroid dysfunction occurs in about 15-20% of patients under amiodarone therapy. Amiodarone-induced hypothyroidism (AIH) can develop in patients with an apparently normal thyroid gland or in those with an underlying chronic autoimmune thyroiditis. On a clinical ground, AIH is not challenging and can be easily treated with L-thyroxine therapy. Amiodarone-induced thyrotoxicosis (AIT) can occur in patients with (AIT 1) or without (AIT 2) an underlying thyroid disease. AIT 1 is a true iodine-induced hyperthyroidism occurring in patients with an underlying thyroid autonomy while AIT 2 is a drug-induced destructive thyroiditis...
March 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28391026/radiopharmaceuticals-in-the-elderly-cancer-patient-practical-considerations-with-a-focus-on-prostate-cancer-therapy-a-position-paper-from-the-international-society-of-geriatric-oncology-task-force
#12
John O Prior, Silke Gillessen, Manfred Wirth, William Dale, Matti Aapro, Wim J G Oyen
Molecular imaging using radiopharmaceuticals has a clear role in visualising the presence and extent of tumour at diagnosis and monitoring response to therapy. Such imaging provides prognostic and predictive information relevant to management, e.g. by quantifying active tumour mass using positron emission tomography/computed tomography (PET/CT). As these techniques require only pharmacologically inactive doses, age and potential frailty are generally not important. However, this may be different for therapy involving radionuclides because the radiation can impact normal bodily function (e...
April 6, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28389624/modeling-therapeutic-response-to-radioiodine-in-metastatic-thyroid-cancer-a%C3%A2-proof-of-concept-study-for-individualized-medicine
#13
Dominique Barbolosi, Ilyssa Summer, Christophe Meille, Raphaël Serre, Antony Kelly, Slimane Zerdoud, Claire Bournaud, Claire Schvartz, Michel Toubeau, Marie-Elisabeth Toubert, Isabelle Keller, David Taïeb
PURPOSE: Radioiodine therapy (RAI) has traditionally been used as treatment for metastatic thyroid cancer, based on its ability to concentrate iodine. Propositions to maximize tumor response with minimizing toxicity, must recognize the infinite possibilities of empirical tests. Therefore, an approach of this study was to build a mathematical model describing tumor growth with the kinetics of thyroglobulin (Tg) concentrations over time, following RAI for metastatic thyroid cancer. EXPERIMENTAL DESIGN: Data from 50 patients with metastatic papillary thyroid carcinoma treated within eight French institutions, followed over 3 years after initial RAI treatments, were included in the model...
March 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28382736/vessel-mapping-for-dialysis-access-planning
#14
Vandana Dua Niyyar, Haimanot Wasse
The population of patients with end-stage renal disease (ESRD) in the United States is progressively increasing, with hemodialysis (HD) as the major mode of renal replacement therapy. National guidelines recommend increasing the use of arteriovenous fistulae (AVF) in both incident and prevalent hemodialysis patients. Pre-operative vascular mapping prior to the surgical creation of an AVF is now considered standard of care and may be helpful in achieving these goals. This manuscript focuses on the advantages and limitations of the various imaging techniques currently available for vessel mapping including physical examination, ultrasonography, angiography (iodinated contrast vs...
April 5, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28382170/obatoclax-and-ly3009120-efficiently-overcome-vemurafenib-resistance-in-differentiated-thyroid-cancer
#15
Wei-Jun Wei, Zhen-Kui Sun, Chen-Tian Shen, Hong-Jun Song, Xin-Yun Zhang, Zhong-Ling Qiu, Quan-Yong Luo
Although the prognosis of differentiated thyroid cancer (DTC) is relatively good, 30-40% of patients with distant metastases develop resistance to radioactive iodine therapy due to tumor dedifferentiation. For DTC patients harboring BRAF(V600E) mutation, Vemurafenib, a BRAF kinase inhibitor, has dramatically changed the therapeutic landscape, but side effects and drug resistance often lead to termination of the single agent treatment. In the present study, we showed that either LY3009120 or Obatoclax (GX15-070) efficiently inhibited cell cycle progression and induced massive death of DTC cells...
2017: Theranostics
https://www.readbyqxmd.com/read/28379897/targeted-radionuclide-therapy-for-lung-cancer-with-iodine-131-labeled-peptide-in-a-nude-mouse-model
#16
Zhenzhu Chen, Hongyi Gao, Man Li, Shun Fang, Guiping Li, Linlang Guo
Integrin α3β1 has been shown to be a novel candidate target for the imaging and specific therapy of non-small-cell lung cancer. We have previously reported on a peptide containing a novel motif of NGXG that specifically binds to the integrin α3 receptor on lung cancer cells using a one-bead one-peptide combinatorial library. In this study, we developed the peptide cNGEGQQc-based therapeutic agent labeling with radionuclide iodine-131 (I) and evaluated its characteristics including stability, biodistribution, antitumor activity, and safety...
June 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/28377140/early-outcomes-of-uveal-melanoma-treated-with-intraoperative-ultrasound-guided-brachytherapy-using-custom-built-plaques
#17
Anne W Tann, Bin S Teh, Sarah B Scarboro, Gary D Lewis, Maria E Bretana, Porshea C Croft, Yuval Raizen, E Brian Butler, Ryan S Kim, Patricia Chevez-Barrios, Amy C Schefler
PURPOSE: To report early outcomes of patients with uveal melanoma treated with Eye Physics iodine-125 episcleral plaque therapy using modern biopsy techniques and intraoperative ultrasound guidance at our institution. METHODS AND MATERIALS: A retrospective chart review was conducted for 48 consecutive patients with uveal melanoma who were treated with Eye Physics plaque brachytherapy performed by 1 ocular oncologist. All patients underwent intraoperative ultrasound for image guidance of plaque placement...
January 7, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28372322/interactions-between-iodinated-contrast-media-and-tissue-plasminogen-activator-in-vitro-comparison-study
#18
Eszter Vörös, László Deres, Róbert Halmosi, Edit Váradi, Kálmán Tóth, István Battyáni
BACKGROUND AND PURPOSE: Iodinated contrast media (Xenetix®, Ultravist®, Omnipaque®, Visipaque® and Iomeron®) used for computed tomography (CT) may decrease fibrinolysis by recombinant tissue plasminogen activator (rt-PA). We hypothesized that receiving iodinated contrast media before rt-PA may impair thrombolysis as measured by a new model system. METHODS: Whole blood from Wistar Kyoto rats (n = 10) was obtained and allowed to form blood clots. Thrombolysis was performed by placing individually the prepared clots into 15 mL tubes and adding 5 mL saline buffer, 100μg rt-PA and a different contrast media; adjusting the quantity of iodine to either 30 mg or 60 mg...
March 30, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28362717/low-activity-versus-high-activity-noninferior-response-to-radioiodine-therapy-in-differentiated-patients-with-extrathyroid-extension
#19
Chen Wang, Teng Zhao, Hui Li, Wen Gao, Yansong Lin
OBJECTIVES: Radioactive iodine (RAI) therapy is recommended for differentiated thyroid cancer (DTC) patients with microscopic extrathyroid extension (ETE). Patients with a low preablative stimulated thyroglobulin (ps-Tg) level have a more favorable prognosis. It remains uncertain whether low-activity RAI could have the same efficacy in patients with low ps-Tg. This study aimed to evaluate the effectiveness of low-activity RAI therapy in low-level ps-Tg DTC with ETE. PATIENTS AND METHODS: The inclusion criteria for this retrospective study were as follows: (a) age 18 years or older, (b) DTC after total or near-total thyroidectomy of DTC, (c) no distant metastasis after thyroidectomy and before RAI therapy, (d) American Joint Committee on Cancer pT3 stage (with microscopic ETE) with any American Joint Committee on Cancer N stage, (e) ps-Tg level of 5 ng/ml or less, and (f) after the first time of RAI therapy...
May 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28361392/noninvasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-historical-context-diagnosis-and-future-challenges
#20
REVIEW
Bin Xu, Giovanni Tallini, Ronald A Ghossein
The encapsulated/well-demarcated non-invasive form of follicular variant of papillary thyroid carcinoma (FVPTC) that occurs annually in 45,000 patients worldwide was thought for 30 years to be a carcinoma. Many studies have now shown almost no recurrence in these non-invasive tumors, even in patients treated by surgery without radioactive iodine therapy. The categorization of the tumor as cancer has led to aggressive forms of treatment, with their side effects, financial costs, and the psychological and social impact of a cancer diagnosis...
March 30, 2017: Endocrine Pathology
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