keyword
https://read.qxmd.com/read/38535766/dual-energy-ct-in-oncologic-imaging
#1
REVIEW
Giovanni Foti, Giorgio Ascenti, Andrea Agostini, Chiara Longo, Fabio Lombardo, Alessandro Inno, Alessandra Modena, Stefania Gori
Dual-energy CT (DECT) is an innovative technology that is increasingly widespread in clinical practice. DECT allows for tissue characterization beyond that of conventional CT as imaging is performed using different energy spectra that can help differentiate tissues based on their specific attenuation properties at different X-ray energies. The most employed post-processing applications of DECT include virtual monoenergetic images (VMIs), iodine density maps, virtual non-contrast images (VNC), and virtual non-calcium (VNCa) for bone marrow edema (BME) detection...
February 23, 2024: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/38535135/comparison-of-echocardiography-and-myocardial-scintigraphy-to-detect-cancer-therapy-related-cardiovascular-toxicity-in-breast-cancer-patients
#2
JOURNAL ARTICLE
Yuko Harada, Kyosuke Shimada, Satoshi John Harada, Tomomi Sato, Yukino Kubota, Miyoko Yamashita
The mortality rate of cancer patients has been decreasing; however, patients often suffer from cardiac disorders due to chemotherapy or other cancer therapies (e.g., cancer-therapy-related cardiovascular toxicity (CVR-CVT)). Therefore, the field of cardio-oncology has drawn more attention in recent years. The first European Society of Cardiology (ESC) guidelines on cardio-oncology was established last year. Echocardiography is the gold standard for the diagnosis of CVR-CVT, but many breast cancer patients are unable to undergo echocardiography due to their surgery wounds or anatomical reasons...
February 21, 2024: Journal of Imaging
https://read.qxmd.com/read/38529769/dosimetry-during-iodine-131-therapy-a-technical-point-of-view-from-a-single-centre-s-own-experience
#3
JOURNAL ARTICLE
Wioletta Chalewska, Paulina Cegla, Anna Moczulska, Edyta Strzemecka, Agata Sackiewicz, Marek Dedecjus
BACKGROUND: Nuclear medicine uses radionuclides in medicine for diagnosis, staging, therapy, and monitoring the response to therapy. The application of radiopharmaceutical therapy for the treatment of certain diseases is well-established, and the field is expanding. Internal dosimetry is multifaceted and includes different workflows, as well as various calculations based on patient- specific dosimetry. AIM: The objective of this study was to introduce the technical issues which might occur during iodine-131 (¹³¹I) dosimetry performed in nuclear medicine departments...
2024: Nuclear Medicine Review. Central & Eastern Europe
https://read.qxmd.com/read/38528653/contrast-free-endovascular-aneurysm-repair-combined-with-fibrin-sealant-filling-for-treating-abdominal-aortic-aneurysm-technical-note
#4
JOURNAL ARTICLE
Longtu Zhu, Wenying Guo, Li Chen, Hao Zhang, Bing Xu, Zhichen Ding, Qingsheng Lu, Lei Zhang
INTRODUCTION: Endovascular aneurysm repair using iodinated contrast agents risks contrast-induced nephropathy, especially in high-risk patients. This technical note describes a contrast-free endovascular aneurysm repair (EVAR) protocol using preoperative imaging measurement and fibrin sealant (FS) filling. TECHNIQUE: Preoperative imaging measurement and intraoperative guidewire manipulation facilitated anatomical identification without contrast. After endograft deployment, the aneurysm sac was filled with FS if endoleak was indicated by pressure fluctuations...
March 25, 2024: Journal of Endovascular Therapy
https://read.qxmd.com/read/38524065/thyroidectomy-effects-on-the-body-mass-index-and-thyroid-stimulating-hormone-a-systematic-review-and-meta-analysis
#5
REVIEW
Hyder Mirghani, Ahmad M Fnjan, Abdullah F Almalki, Ali F Almadan, Omar Abdullah M Alammar, Abdulaziz S Alhwiati, Amer A Laradhi, Ahmed M Bakour, Mohamad A Aljahed, Abdulmajeed M Alzahrani
Thyroidectomy is common and is performed for malignancy, goiters with pressure symptoms, and certain types of Grave's disease. Weight and body mass index (BMI) following thyroidectomy were discussed controversially. This meta-analysis aimed to assess weight and BMI following thyroidectomy. A systematic literature search was conducted in PubMed, Medline, and Google Scholar with interest in articles that assessed body weight and BMI following total or subtotal thyroidectomy. The search engine was limited to the period from inception up to January 2024...
February 2024: Curēus
https://read.qxmd.com/read/38523225/implementation-of-the-targeted-axillary-dissection-procedure-in-clinically-node-positive-breast-cancer-a-retrospective-analysis
#6
JOURNAL ARTICLE
Joni J Nijveldt, Kiran K Rajan, Karina Boersma, Eva M Noorda, Jose van der Starre-Gaal, Miranda van 't Veer-Ten Kate, Ellen M A Roeloffzen, Brian N Vendel, Maarten A Beek, Anne Brecht Francken
BACKGROUND: The targeted axillary dissection (TAD) procedure is used in clinically positive lymph node (cN+) breast cancer to assess whether pathological complete response (pCR) is achieved after neoadjuvant systemic therapy (NST) to decide on de-escalation of axillary lymph node dissection (ALND). In this study, we review the implementation of the TAD procedure in a large regional breast cancer center. METHODS: All TAD procedures between 2016 and 2022 were reviewed...
March 24, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38517359/pet-spect-spectral-ct-cbct-imaging-in-a-small-animal-radiation-therapy-platform-a-monte-carlo-study-part-ii-biologically-guided-radiotherapy
#7
JOURNAL ARTICLE
Xiadong Li, Hui Wang, Lixia Xu, Yu Kuang
BACKGROUND: This study addresses the technical gap between clinical radiation therapy (RT) and preclinical small-animal RT, hindering the comprehensive validation of innovative clinical RT approaches in small-animal models of cancer and the translation of preclinical RT studies into clinical practices. PURPOSE: The main aim was to explore the feasibility of biologically guided RT implemented within a small-animal radiation therapy (SART) platform, with integrated quad-modal on-board positron emission tomography (PET), single-photon emission computed tomography, photon-counting spectral CT, and cone-beam CT (CBCT) imaging, in a Monte Carlo model as a proof-of-concept...
March 22, 2024: Medical Physics
https://read.qxmd.com/read/38510823/augmentation-of-radioiodine-uptake-by-pulmonary-metastasis-of-papillary-thyroid-carcinoma-treated-with-dabrafenib-and-trametinib
#8
JOURNAL ARTICLE
Elona Malja, Asha Kandathil, Fangyu Peng
Redifferentiation therapy with Dabrafenib (a BRAF inhibitor) and Trametinib (a MEK inhibitor) restores radioiodine avidity of radioiodine-refractory papillary thyroid carcinoma (PTC). A 50-year-old man was diagnosed with radioiodine-refractory PTC pulmonary metastasis post prior total thyroidectomy and radioiodine ablation. The patient was treated with Dabrafenib and Trametinib, followed by second radioiodine ablation with I-131 sodium iodine. Diffuse increased radioiodine uptake by pulmonary metastasis was visualized on post ablation whole body scan...
April 2024: Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38509509/grade-adolopment-of-hyperthyroidism-treatment-guidelines-for-a-pakistani-context
#9
JOURNAL ARTICLE
Russell Seth Martins, Sarah Nadeem, Abeer Aziz, Sajjan Raja, Alina Pervez, Najmul Islam, Asma Ahmed, Aisha Sheikh, Saira Furqan, Nanik Ram, Azra Rizwan, Nashia Ali Rizvi, Mohsin Ali Mustafa, Salima Saleem Aamdani, Bushra Ayub, Muhammad Qamar Masood
INTRODUCTION: The prevalence of hyperthyroidism in Pakistan is 2.9%, which is two times higher than in the United States. Most high-quality hyperthyroidism clinical practice guidelines (CPGs) used internationally originate from high-income countries in the West. Local CPGs in Pakistan are not backed by transparent methodologies. We aimed to produce comprehensive, high-quality CPGs for the management of hyperthyroidism in Pakistan. METHODS: We employed the GRADE-ADOLOPMENT approach utilizing the 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis as the source CPG...
March 21, 2024: BMC Endocrine Disorders
https://read.qxmd.com/read/38503602/theranostics-of-thyroid-cancer
#10
REVIEW
Luca Giovanella, Murat Tuncel, Atena Aghaee, Alfredo Campenni, Petra Petranović Ovčariček, Armando De Virgilio
Molecular imaging is pivotal in evaluating and managing patients with different thyroid cancer histotypes. The existing, pathology-based, risk stratification systems can be usefully refined, by incorporating tumor-specific molecular and molecular imaging biomarkers with theranostic value, allowing patient-specific treatment decisions. Molecular imaging with different radioactive iodine isotopes (ie, I131 , I123 , I124 ) is a central component of differentiated carcinoma (DTC)'s risk stratification while [18 F]F-fluorodeoxyglucose ([18 F]FDG) PET/CT is interrogated about disease aggressiveness and presence of distant metastases...
March 18, 2024: Seminars in Nuclear Medicine
https://read.qxmd.com/read/38500743/unexpected-99m-tc-pertechnetate-avidity-of-lymph-node-metastases-predicts-better-response-to-radioiodine-therapy-in-differentiated-thyroid-cancer-patients-with-lymph-node-metastases
#11
JOURNAL ARTICLE
Jie Liu, Xin Li, Linfa Li, Yuhua Yin, Hu Cai, Heqing Yi
OBJECTIVE: To investigate the value of 99m Tc-pertechnetate scan in postoperative differentiated thyroid cancer (DTC) patients with lymph node (LN) metastases (LNM) uptake 99m Tc-pertechnetate, especially the predictive value to their response to radioiodine-131 (131 I) therapy. METHODS: This retrospective study collected 752 patients with DTC and LNM treated at Zhejiang Cancer Hospital between May 2012 and December 2017. Depending on the ability of LNM uptake 99m Tc-pertechnetate, the patients were grouped as the 99m Tc-pertechnetate-avid (n=88) vs...
2024: American Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/38499879/just-give-the-contrast-appraisal-of-guidelines-on-intravenous-iodinated-contrast-media-use-in-patients-with-kidney-disease
#12
JOURNAL ARTICLE
Jingyu Zhong, Liwei Chen, Yue Xing, Junjie Lu, Yuping Shi, Yibin Wang, Yi Deng, Run Jiang, Wenjie Lu, Silian Wang, Yangfan Hu, Xiang Ge, Defang Ding, Huan Zhang, Ying Zhu, Weiwu Yao
OBJECTIVE: To appraise the quality of guidelines on intravenous iodinated contrast media (ICM) use in patients with kidney disease, and to compare the recommendations among them. METHODS: We searched four literature databases, eight guideline libraries, and ten homepages of radiological societies to identify English and Chinese guidelines on intravenous ICM use in patients with kidney disease published between January 2018 and June 2023. The quality of the guidelines was assessed with the Scientific, Transparent, and Applicable Rankings (STAR) tool...
March 18, 2024: Insights Into Imaging
https://read.qxmd.com/read/38495395/an-unlikely-source-of-iodine-uptake-a-bronchogenic-cyst-masquerading-as-metastatic-thyroid-cancer
#13
Martha Dillon, Rachel Zielinski, Jennifer Worth, Melinda Sanders, Omar Ibrahim, Tarunya Vedere
Radioactive iodine therapy and posttreatment scanning are essential components of differentiated thyroid carcinoma treatment and detection of metastatic disease. False-positive results can be seen on an I-131 scan and are important for clinicians to be aware of. Here, we present a case of a 33-year-old female with follicular thyroid carcinoma who was noted to have an area of moderate uptake in the chest on a whole-body scan following remnant ablation with 30 mCi of I-131 (1.11GBq) concerning for a metastatic hilar lymph node...
March 2024: JCEM Case Rep
https://read.qxmd.com/read/38490098/uncommon-diagnosis-of-multinodular-goiter-isolated-extrapulmonary-manifestation-of-sarcoidosis-in-thyroid-gland-scientific-case-reports
#14
Marcel Neumann, Frank Meyer, Tatiana Oksentyuk Polyakova, Udo Barth, Dörthe Jechorek, Roland S Croner, Manuela Petersen
AIM: By means of the scientific description of two uncommon cases who underwent. surgical resection of multinodous goiter and following histopathological investigation revealing isolated extrapulmonary manifestation of sarcoidosis, this uncommon diagnosis including symptomatology, clinical findings, diagnostic and therapeutic management is to be illustrated. CASE DESCRIPTIONS: Diagnostics: Scintigraphy of the thyroid gland with a left-thyroid cold node; ultrasound-guided puncture (cytological investigation, non-suspicious)...
March 8, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38464386/recent-preclinical-and-clinical-advances-in-radioimmunotherapy-for-non-hodgkin-s-lymphoma
#15
REVIEW
Hiroki Goto, Yoshioki Shiraishi, Seiji Okada
Radioimmunotherapy (RIT) is a therapy that combines a radioactive nucleotide with a monoclonal antibody (mAb). RIT enhances the therapeutic effect of mAb and reduces toxicity compared with conventional treatment. The purpose of this review is to summarize the current progress of RIT for treating non-Hodgkin's lymphoma (NHL) based on recent preclinical and clinical studies. The efficacy of RIT targeting the B-lymphocyte antigen cluster of differentiation 20 (CD20) has been demonstrated in clinical trials. Two radioimmunoconjugates targeting CD20, yttrium-90 (90 Y)-ibritumomab-tiuxetan (Zevalin) and iodine-131 (131 I)-tositumomab (Bexxar), have been approved in the USA Food and Drug Administration (FDA) for treating relapsed/refractory indolent or transformed NHL in 2002 and 2003, respectively...
2024: Exploration of targeted anti-tumor therapy
https://read.qxmd.com/read/38455350/seeding-recurrence-of-follicular-thyroid-carcinoma-after-transoral-endoscopic-thyroidectomy-vestibular-approach-a-case-report
#16
Moon Young Oh, So Won Oh, Young A Kim, Young Jun Chai
BACKGROUND: While track recurrence of thyroid cancer following endoscopic and robotic transaxillary surgeries has been reported previously, no such cases have been reported for transoral endoscopic thyroidectomy vestibular approach (TOETVA). This case report describes the first documented case of recurrence of thyroid cancer along the surgical track after TOETVA. CASE DESCRIPTION: The patient underwent right lobectomy via TOETVA for a 4 cm follicular thyroid carcinoma (FTC) initially diagnosed as benign follicular nodule on preoperative gun biopsy...
February 29, 2024: Gland Surgery
https://read.qxmd.com/read/38455001/rapid-high-capacity-adsorption-of-iodine-from-aqueous-environments-with-amide-functionalized-covalent-organic-frameworks
#17
JOURNAL ARTICLE
Niyati Arora, Tanay Debnath, Milinda C Senarathna, Rebecca M Johnson, Isabella G Roske, G Andrés Cisneros, Ronald A Smaldone
The uses and production of radionuclides in nuclear energy production and medical therapy are becoming more significant in today's world. While these applications have many benefits, they can produce harmful pollutants, such as radioactive iodine, that need to be sequestered. Effective capture and storage of radioactive iodine waste remains a major challenge for nuclear energy generation and nuclear medicine. Here we report the highly efficient capture of iodine in a series of mesoporous, two-dimensional (2D) covalent organic frameworks, called COFamides, which contain amide sidechains in their pores...
March 6, 2024: Chemical Science
https://read.qxmd.com/read/38453358/the-accomplishments-and-legacy-of-saul-hertz-md
#18
JOURNAL ARTICLE
Bennett S Greenspan, Michael S Hofman, John Buscombe
The early history of the use of radioactive iodine (RAI) is complicated and interesting, and also difficult to discover, especially since several histories have presented inaccurate content. This article is a comprehensive review of the accomplishments of Saul Hertz. Extensive use of primary-source verification has clarified several issues, including the question of whether Hertz alone conceived and asked the pivotal question: "Could iodine be made radioactive artificially?"; on what date RAI was first used to treat hyperthyroidism; and why 2 articles on the first use of RAI for treatment of hyperthyroidism, from 2 different sets of authors from the same department of the same institution, appeared adjacent to each other in the same issue of the Journal of the American Medical Association in 1946...
March 7, 2024: Journal of Nuclear Medicine
https://read.qxmd.com/read/38452309/an-era-of-advances-in-systemic-therapies-for-advanced-thyroid-cancer
#19
REVIEW
Karen M Yun, Ezra E W Cohen
Thyroid carcinomas comprise distinct pathologic subtypes. However, advancements in characterizing the molecular tumorigenesis of thyroid cancers have changed the treatment paradigm in the past decade. Genetic profiling has become an integral component of personalizing cancer care. Oral kinase inhibitors are currently standard-of-care therapies for progressive, radioactive iodine (RAI)-refractory differentiated thyroid carcinomas (DTCs) and medullary thyroid carcinomas (MTCs). Sorafenib, lenvatinib, and cabozantinib are multikinase inhibitors approved for patients with metastatic RAI-refractory DTC, whereas vandetanib and cabozantinib are approved for patients with MTC...
March 7, 2024: JCO oncology practice
https://read.qxmd.com/read/38451055/atorvastatin-loaded-cubosome-a-repurposed-targeted-delivery-systems-for-enhanced-targeting-against-breast-cancer
#20
JOURNAL ARTICLE
Eman M El-Marakby, Hend Fayez, M A Motaleb, Mai Mansour
Cancer ranks as one of the most challenging illnesses to deal with because progressive phenotypic and genotypic alterations in cancer cells result in resistance and recurrence. Thus the creation of novel medications or alternative therapy approaches is mandatory. Repurposing of old drugs is an attractive approach over traditional drug discovery process in terms of shorter drug development duration, low-cost, highly efficient and minimum risk of failure. In this study Atorvastatin, a statin drug used to treat abnormal cholesterol levels and prevent cardiovascular disease in people at high risk, was introduced and encapsulated in cubic liquid crystals as anticancer candidate aiming at sustaining its release and achieving better cellular uptake in cancer cells...
March 7, 2024: Pharmaceutical Development and Technology
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