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Marion Guerrero-Wyss, Samuel Durán Agüero, Lisse Angarita Dávila
The objective of the current research was to review and update evidence on the dietary effect of the consumption of tagatose in type 2 diabetes, as well as to elucidate the current approach that exists on its production and biotechnological utility in functional food for diabetics. Articles published before July 1, 2017, were included in the databases PubMed, EBSCO, Google Scholar, and Scielo, including the terms "Tagatose", "Sweeteners", "Diabetes Mellitus type 2", "Sweeteners", "D-Tag"...
2018: BioMed Research International
Shin Watanabe, Kenneth Fish, Jason C Kovacic, Olympia Bikou, Lauren Leonardson, Koichi Nomoto, Jaume Aguero, Navin K Kapur, Roger J Hajjar, Kiyotake Ishikawa
BACKGROUND: Delivering therapeutic materials, like stem cells or gene vectors, to the myocardium is difficult in the setting of ischemic heart failure because of decreased coronary flow and impaired microvascular perfusion (MP). The aim of this study was to determine if mechanical left ventricular (LV) unloading with the Impella increases coronary flow and MP in a subacute myocardial infarction. METHODS AND RESULTS: Anterior transmural myocardial infarction (infarct size, 26...
March 7, 2018: Journal of the American Heart Association
Samuel Durán Agüero, Lissé Angarita Dávila, Ma Cristina Escobar Contreras, Diana Rojas Gómez, Jorge de Assis Costa
Noncaloric sweeteners (NCS) are food additives used to provide sweetness without adding calories. Their consumption has become more widespread around the world in all age groups, including children. The aim of this study is to show the state of the art about the intake of noncaloric sweeteners in children, as well as their benefits and consumption risk. Scientific searchers were used (PUBMED, Scopus, and Scielo) to analyze articles that included keywords (noncaloric sweeteners/saccharin/cyclamate/acesulfame potassium/aspartame/sucralose/stevia/children) in English, Spanish, and Portuguese...
2018: BioMed Research International
Mathilde J H Girard-Madoux, Mercedes Gomez de Agüero, Stephanie C Ganal-Vonarburg, Catherine Mooser, Gabrielle T Belz, Andrew J Macpherson, Eric Vivier
Biological redundancy ensures robustness in living organisms at several levels, from genes to organs. In this review, we explore the concept of redundancy and robustness through an analysis of the caecal appendix, an organ that is often considered to be a redundant remnant of evolution. However, phylogenic data show that the Appendix was selected during evolution and is unlikely to disappear once it appeared. In humans, it is highly conserved and malformations are extremely rare, suggesting a role for that structure...
March 1, 2018: Seminars in Immunology
Miguel García-Rojas, Marco Meneses, Kristen Oviedo, Carlos Carrasco, Bruno Defilippi, Mauricio González-Agüero, Gabriel León, Patricio Hinrichsen
Most table grape (Vitis vinifera L.) varieties require gibberellic acid (GA3 ) applications to obtain an adequate berry size in order to satisfy market requirements. However, GA3 treatments also produce severe berry drop in some cultivars, which occurs mainly after a cold storage period during post-harvest. Berry drop in bunches treated with GA3 has been related to the hardening and thickening of the pedicel produced by the over-accumulation of cellulose and its lignification. The main goal of this study was to compare the morphology and gene expression in pedicel samples of genotypes contrasting for berry drop susceptibility...
February 21, 2018: Plant Physiology and Biochemistry: PPB
Inés Luis de Redín, Carolina Boiero, María Cristina Martínez-Ohárriz, Maite Agüeros, Rocío Ramos, Iván Peñuelas, Daniel Allemandi, Juan M Llabot, Juan M Irache
Bevacizumab-loaded nanoparticles (B-NP) were prepared by a desolvation process followed by freeze-drying, without any chemical, physical or enzymatic cross-linkage. Compared with typical HSA nanoparticles cross-linked with glutaraldehyde (B-NP-GLU), B-NP displayed a significantly higher mean size (310 nm vs. 180 nm) and a lower negative zeta potential (-15 mV vs. -36 mV). On the contrary, B-NP displayed a high payload of approximately 13% when measured by a specific ELISA, whereas B-NP-GLU presented a very low bevacizumab loading (0...
February 23, 2018: International Journal of Pharmaceutics
Cristina Martínez, Ciro Casanova, Juan P de-Torres, José M Marín, Pilar de Lucas, Antonia Fuster, Borja G Cosío, Myriam Calle, Germán Peces-Barba, Ingrid Solanes, Ramón Agüero, Nuria Feu-Collado, Inmaculada Alfageme, Amparo Romero Plaza, Eva Balcells, Alfredo de Diego, Margarita Marín Royo, Amalia Moreno, Antonia Llunel Casanova, Juan B Galdiz, Rafael Golpe, Celia Lacárcel Bautista, Carlos Cabrera, Alicia Marin, Joan B Soriano, Jose Luis Lopez-Campos
BACKGROUND: Despite the existing evidence-based smoking cessation interventions, chances of achieving that goal in real-life are still low among COPD patients. We sought to evaluate the clinical consequences of changes in smoking habits in a large cohort of COPD patients. METHODS: CHAIN is a Spanish multicenter study carried out at pulmonary clinics including active and former smokers with COPD. Smoking status was certified by clinical history and co-oximetry. Clinical presentation and disease impact were recorded via validated questionnaires, including the London Chest Activity of Daily Living (LCADL) and the Hospital Anxiety and Depression Scale (HADS)...
February 21, 2018: Chest
Alejandro Gomez-Bruton, Alejandro Gonzalez-Aguero, Angel Matute-Llorente, Alba Gomez-Cabello, Jose A Casajus, German Vicente-Rodríguez
The aims of the present study were, firstly, to evaluate areal bone mineral density (aBMD), bone strength and structure during a swimming season and compare them to those of normo-active controls (CG), and secondly to ascertain whether practising an additional weight-bearing sport other than swimming might improve bone. Twenty-three swimmers who only swam (SWI-PURE; 14 males, 9 females), 11 swimmers who combined swimming with an additional weight-bearing sport (SWI-SPORT; 8 males, 3 females) and 28 controls (CG; 16 males, 12 females) participated in the present study...
December 2017: Biology of Sport
Laura Martí Gelonch, Raul Jiménez Agüero, Nerea Rodríguez Canas, Jose Maria Enríquez Navascués
No abstract text is available yet for this article.
February 15, 2018: Gastroenterología y Hepatología
Pablo Valdés-Badilla, Andrés Godoy-Cumillaf, Jenny Ortega-Spuler, Tomás Herrera-Valenzuela, Samuel Durán-Agüero, José Zapata-Bastias, Rodrigo Vargas-Vitoria, Eduardo Guzmán-Muñoz, Antonio López-Fuenzalida
OBJECTIVE: To associate health anthropometric indexes with physical fitness of elderly women (EW) who participate in physical exercise workshops. MATERIALS AND METHODS: 272 Chilean women over 60 years took part in the study. The variables studied were BMI, waist circumference (WC), waist-height index (WHI) and physical fitness (PF). Correlations were made through the Pearson or Spearman coefficient, and bivariate associations using Pearson's Chi-square and the Fisher's exact test, considering p<0...
November 2017: Salud Pública de México
Javier E Ortiz, Adriana Garro, Natalia B Pigni, María Belén Agüero, German Roitman, Alberto Slanis, Ricardo D Enriz, Gabriela E Feresin, Jaume Bastida, Alejandro Tapia
BACKGROUND: In Argentina, the Amaryllidaceae family (59 species) comprises a wide variety of genera, only a few species have been investigated as a potential source of cholinesterases inhibitors to treat Alzheimer disease (AD). PURPOSE: To study the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities of the basic dichloromethane extracts (E) from Hieronymiella aurea, H. caletensis, H. clidanthoides, H. marginata, and H. speciosa species, as well as the isolated compounds from these plant extracts...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Hugo Olmedillas, Alejandro Gonzalez-Agüero, Marta Rapún-López, Luis Gracia-Marco, Alba Gomez-Cabello, Francisco Pradas de la Fuente, Luís A Moreno, José A Casajús, Germán Vicente-Rodríguez
This study aimed to describe bone metabolic activity in adolescent competitive cyclists compared to age-matched controls. The main result is that younger subjects present a higher bone turnover than the older ones. Moreover, cyclists under the age of 17 have higher scores on all markers than age-matched controls. PURPOSE: The purpose of this study was to describe bone metabolic activity in adolescent competitive cyclists compared to age-matched controls. METHODS: Twenty-two male adolescent cyclists between 14 and 20 years (y) and 20 age-matched controls participated in this study...
February 3, 2018: Archives of Osteoporosis
Polyxeni Gkontra, Kerri-Ann Norton, Magdalena M Żak, Cristina Clemente, Jaume Agüero, Borja Ibáñez, Andrés Santos, Aleksander S Popel, Alicia G Arroyo
The microvasculature continuously adapts in response to pathophysiological conditions to meet tissue demands. Quantitative assessment of the dynamic changes in the coronary microvasculature is therefore crucial in enhancing our knowledge regarding the impact of cardiovascular diseases in tissue perfusion and in developing efficient angiotherapies. Using confocal microscopy and thick tissue sections, we developed a 3D fully automated pipeline that allows to precisely reconstruct the microvasculature and to extract parameters that quantify all its major features, its relation to smooth muscle actin positive cells and capillary diffusion regions...
January 30, 2018: Scientific Reports
Estrella Gómez-Tortosa, María Ruggiero, Ma José Sainz, Alberto Villarejo-Galende, Cristina Prieto-Jurczynska, Begoña Venegas Pérez, Carlos Ordás, Pablo Agüero, Rosa Guerrero-López, Julián Pérez-Pérez
The SORL1 gene encodes a protein involved in the amyloidogenic process, and its variants have been associated with Alzheimer's disease (AD) physiopathology. We screened for SORL1 variants in 124 familial (44 early- and 80 late-onset) dementia of Alzheimer type (DAT) cases. Nine potentially pathogenic changes (three not previously reported and six rare variants) were found in nine probands (7%). After screening the control population and siblings (presence in at least 1/200 controls and/or absence of segregation pattern), a causal relationship with the disease was considered unlikely in six variants and uncertain in one...
2018: Journal of Alzheimer's Disease: JAD
Maria J Perugorria, Aitor Esparza-Baquer, Fiona Oakley, Ibone Labiano, Ana Korosec, Alexander Jais, Jelena Mann, Dina Tiniakos, Alvaro Santos-Laso, Ander Arbelaiz, Riem Gawish, Ana Sampedro, Antonio Fontanellas, Elizabeth Hijona, Raul Jimenez-Agüero, Harald Esterbauer, Dagmar Stoiber, Luis Bujanda, Jesus María Banales, Sylvia Knapp, Omar Sharif, Derek A Mann
OBJECTIVE: Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in bone marrow (BM)-derived macrophages but its function in liver injury is unknown. Here we hypothesised that the anti-inflammatory effects of TREM-2 on TLR signalling may limit hepatic injury. DESIGN: TREM-2 expression was analysed in livers of humans with various forms of liver injury compared with control individuals...
January 27, 2018: Gut
Sandra Pérez-Agüeros, Joanna María Ortiz-Alcántara, Fabiola Garcés-Ayala, Edgar Mendieta-Condado, Elizabeth González-Durán, Nidia Aréchiga-Ceballos, Martin Melo-Munguía, Susana Chávez-López, Albert Sandoval-Borja, Mauricio Gómez-Sierra, Rita Terán-Toledo, David Martínez-Solís, Israel Animas-Vargas, Beatriz Escamilla-Ríos, Belem Torres-Longoria, Irma López-Martínez, Lucía Hernández-Rivas, José Alberto Díaz-Quiñonez, José Ernesto Ramírez-González
Rabies virus (RABV), a member of the genus Lyssavirus, causes encephalitis that is almost always fatal following the onset of clinical signs. Here, we report the complete codifying sequence of an RABV isolated from a dog in Mexico. Molecular data showed that this strain belongs to the Chiapas lineage.
January 25, 2018: Genome Announcements
Shuhua Luo, Celeste Foreman, Minako Sano, Maria Jose Soto Agüero, Anne-Marie Guerguerian, Roxanne Kirsch, Tilman Humpl, Lennox Huang, Osami Honjo
A chimney femoral artery graft for peripheral extracorporeal membrane oxygenation can potentially cause hyperperfusion and subsequent venous congestion in the ipsilateral leg, especially in the context of septic shock and higher flow requirement. This report describes a novel technique to use an additional leg venous cannula to avoid leg congestion as well as to achieve higher total flow.
February 2018: Annals of Thoracic Surgery
Erasmo Negrete-Abascal, Fernando Montes-Garcia, Sergio Vaca-Pacheco, Abraham M Leyto-Gil, Edgar Fragoso-Garcia, Roberto Carvente-Garcia, Sandra Perez-Agueros, Hugo G Castelan-Sanchez, Alejandra Garcia-Molina, Tomas E Villamar, Patricia Sánchez-Alonso, Candelario Vazquez-Cruz
The draft genome sequence of Actinobacillus seminis strain ATCC 15768 is reported here. The genome comprises 22 contigs corresponding to 2.36 Mb with 40.7% G+C content and contains several genes related to virulence, including a putative RTX protein.
January 11, 2018: Genome Announcements
Karen Newman, Tristan Aguero, Mary Lou King
Xenopus oocytes and oocyte extracts are the starting material for a variety of experimental approaches. Oocytes are obtained by surgical removal of the ovary from anesthetized females. Although oocytes may be used while they remain within their ovarian follicle, it is more practical to work with defolliculated oocytes. Defolliculation can be performed either manually or enzymatically. Here we present a protocol for the isolation and separation of Xenopus oocytes at various developmental stages, and guidelines for maintaining oocytes in culture...
January 10, 2018: Cold Spring Harbor Protocols
Tristan Aguero, Karen Newman, Mary Lou King
Microinjection of Xenopus oocytes has proven to be a valuable tool in a broad array of studies that require expression of DNA or RNA into functional protein. These studies are diverse and range from expression cloning to receptor-ligand interaction to nuclear programming. Oocytes offer a number of advantages for such studies, including their large size (∼1.2 mm in diameter), capacity for translation, and enormous nucleus (0.3-0.4 mm). They are cost effective, easily manipulated, and can be injected in large numbers in a short time period...
January 10, 2018: Cold Spring Harbor Protocols
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