keyword
MENU ▼
Read by QxMD icon Read
search

aguero

keyword
https://www.readbyqxmd.com/read/28935948/novel-scaffolds-for-inhibition-of-cruzipain-identified-from-high-throughput-screening-of-anti-kinetoplastid-chemical-boxes
#1
Emir Salas-Sarduy, Lionel Urán Landaburu, Joel X Karpiak, Kevin P Madauss, Juan José Cazzulo, Fernán Agüero, Vanina Eder Alvarez
American Trypanosomiasis or Chagas disease is a prevalent, neglected and serious debilitating illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi. The current chemotherapy is limited only to nifurtimox and benznidazole, two drugs that have poor efficacy in the chronic phase and are rather toxic. In this scenario, more efficacious and safer drugs, preferentially acting through a different mechanism of action and directed against novel targets, are particularly welcome. Cruzipain, the main papain-like cysteine peptidase of T...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28922472/mirna-506-promotes-primary-biliary-cholangitis-like-features-in-cholangiocytes-and-immune-activation
#2
Oihane Erice, Patricia Munoz-Garrido, Javier Vaquero, Maria J Perugorria, Maite G Fernandez-Barrena, Elena Saez, Alvaro Santos-Laso, Ander Arbelaiz, Raul Jimenez-Agüero, Joaquin Fernandez-Irigoyen, Enrique Santamaria, Verónica Torrano, Arkaitz Carracedo, Meenakshisundaram Ananthanarayanan, Marco Marzioni, Jesus Prieto, Ulrich Beuers, Ronald P Oude Elferink, Nicholas F LaRusso, Luis Bujanda, Jose J G Marin, Jesus M Banales
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease associated with autoimmune phenomena targeting intrahepatic bile duct cells (cholangiocytes). Although PBC etiopathogenesis still remains obscure, development of anti-mitochondrial auto-antibodies against pyruvate dehydrogenase complex-E2 (PDC-E2) is a common feature. MicroRNA (miR) dysregulation occurs in liver and immune cells of PBC patients, but their functional relevance is largely unknown. We previously reported that miR-506 is overexpressed in PBC cholangiocytes and directly targets both Cl(-) /HCO3(-) anion exchanger 2 (AE2) and type III inositol 1,4,5-trisphosphate receptor (InsP3R3), leading to cholestasis...
September 18, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28916388/differential-effects-of-fxr-or-tgr5-activation-in-cholangiocarcinoma-progression
#3
O Erice, I Labiano, A Arbelaiz, A Santos-Laso, P Munoz-Garrido, R Jimenez-Agüero, P Olaizola, A Caro-Maldonado, N Martín-Martín, A Carracedo, E Lozano, J J Marin, C J O'Rourke, J B Andersen, J Llop, V Gómez-Vallejo, D Padro, A Martin, M Marzioni, L Adorini, M Trauner, L Bujanda, M J Perugorria, J M Banales
BACKGROUND AND AIMS: Cholangiocarcinoma (CCA) is an aggressive tumor type affecting cholangiocytes. CCAs frequently arise under certain cholestatic liver conditions. Intrahepatic accumulation of bile acids may facilitate cocarcinogenic effects by triggering an inflammatory response and cholangiocyte proliferation. Here, the role of bile acid receptors FXR and TGR5 in CCA progression was evaluated. METHODS: FXR and TGR5 expression was determined in human CCA tissues and cell lines...
September 12, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28902628/physical-activity-and-bone-mineral-density-at-the-femoral-neck-subregions-in-adolescents-with-down-syndrome
#4
Ángel Matute-Llorente, Alejandro González-Agüero, Germán Vicente-Rodríguez, Luís B Sardinha, Fátima Baptista, José A Casajús
BACKGROUND: Low bone mineral density (BMD) has been frequently described in subjects with Down syndrome (DS). Reduced physical activity (PA) levels may contribute to low BMD in this population. The objective of the study was to investigate whether PA levels were related to the femoral neck bone mass distribution in a sample of 14 males and 12 females with DS aged 12-18 years. METHODS: BMD was evaluated by dual energy X-ray absorptiometry (DXA) at the integral, superolateral and inferomedial femoral neck regions and PA levels were assessed by accelerometry...
September 13, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28870987/maternal-dead-end-1-promotes-translation-of-nanos1-through-binding-the-eif3-complex
#5
Tristan Aguero, Zhigang Jin, Sandip Chorghade, Auinash Kalsotra, Mary Lou King, Jing Yang
In the developing embryo, primordial germ cells (PGCs) represent the exclusive progenitors of the gametes, and their loss results in adult infertility. During early development, PGCs are exposed to numerous signals that specify somatic cell fates. To prevent somatic differentiation, PGCs must transiently silence their genome, an early developmental process that requires Nanos activity. However, it is unclear how nanos translation is regulated in developing embryos. We report here that translation of nanos1 after fertilization requires Dead End1 (Dnd1), a vertebrate-specific germline RNA-binding protein...
September 4, 2017: Development
https://www.readbyqxmd.com/read/28819692/molecular-characterization-of-atypical-antigenic-variants-of-canine-rabies-virus-reveals-its-reintroduction-by-wildlife-vectors-in-southeastern-mexico
#6
Fabiola Garcés-Ayala, Nidia Aréchiga-Ceballos, Joanna M Ortiz-Alcántara, Elizabeth González-Durán, Sandra I Pérez-Agüeros, Alfonso Méndez-Tenorio, Belem Torres-Longoria, Irma López-Martínez, Lucía Hernández-Rivas, José Alberto Díaz-Quiñonez, José Ernesto Ramírez-González
Rabies is an infectious viral disease that is practically always fatal following the onset of clinical signs. In Mexico, the last case of human rabies transmitted by dogs was reported in 2006 and canine rabies has declined significantly due to vaccination campaigns implemented in the country. Here we report on the molecular characterization of six rabies virus strains found in Yucatan and Chiapas, remarkably, four of them showed an atypical reaction pattern when antigenic characterization with a reduced panel of eight monoclonal antibodies was performed...
August 17, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28815739/kernicterus-in-a-boy-with-ornithine-transcarbamylase-deficiency-a-case-report
#7
Eduardo López-Corella, Isabel Ibarra-González, Cynthia Fernández-Lainez, Miguel Á Rodríguez-Weber, Sara Guillén-Lopez, Leticia Belmont-Martínez, David Agüero-Linares, Marcela Vela-Amieva
Ornithine transcarbamylase deficiency (OTCD) is an X-linked urea cycle defect associated with severe and usually fatal hyperammonemia. This study describes a patient with early onset lethal OTCD due to a known pathogenic variant (c.298+1G>A), as well as the novel autopsy finding of kernicterus with relatively low blood concentration of unconjugated bilirubin (UCB) (11.55 mg/dL). The patient was a full-term male with a family history of two previous male siblings who died as newborns after acute neurologic deterioration...
August 16, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28809540/simplified-modeling-of-organic-contaminant-adsorption-by-activated-carbon-and-biochar-in-the-presence-of-dissolved-organic-matter-and-other-competing-adsorbates
#8
Kyle K Shimabuku, Julian M Paige, Marisol Luna-Aguero, R Scott Summers
Cyclohexanol, phenol, benzoic acid, and phenanthrene fractional removal (italicized words are defined within the main text) by pulverized granular activated carbon and biochar adsorption in deionized water and stormwater was independent of target-adsorbate initial concentrations (C0) when C0s were below concentration thresholds. This permits a simple-modeling approach. C0-independent removal in deionized water at low-target-adsorbate concentrations potentially suggests that DOM in the deionized water induce a competitive effect that causes deviations from the Freundlich model...
August 25, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28798965/increased-afterload-following-myocardial-infarction-promotes-conduction-dependent-arrhythmias-that-are-unmasked-by-hypokalemia
#9
Lukas J Motloch, Kiyotake Ishikawa, Chaoqin Xie, Jun Hu, Jaume Aguero, Kenneth M Fish, Roger J Hajjar, Fadi G Akar
Although the pathophysiological significance of resistant hypertension in post-myocardial infarction (MI) patients is established, mechanisms by which increased afterload in that setting worsens outcome are unclear. With regards to sudden cardiac death, whether increased afterload alters the electrophysiological substrate following MI is unknown. We established a new large animal model of chronic post-MI remodeling with increased afterload which exhibits widespread deposition of fibrosis in remote areas from the anterior MI, mimicking the disease phenotype of patients with advanced ischemic heart disease...
June 2017: JACC. Basic to Translational Science
https://www.readbyqxmd.com/read/28733931/do-6%C3%A2-months-of-whole-body-vibration-training-improve-lean-mass-and-bone-mass-acquisition-of-adolescent-swimmers
#10
A Gómez-Bruton, A González-Agüero, A Matute-Llorente, C Julián, G Lozano-Berges, A Gómez-Cabello, J A Casajús, G Vicente-Rodríguez
Swimming has little effect on bone mass. Therefore, adolescent swimmers should complement their water training with a short and intense weight-bearing training, aiming to increase their bone acquisition. Forty swimmers performed a six-month whole-body vibration (WBV) training. WBV had no effect on adolescent swimmers' bone mass or lean mass. PURPOSE: The aims of the present study were to evaluate the effects of a whole-body vibration (WBV) intervention on bone mineral density (BMD), bone mineral content (BMC) and lean mass (LM) in adolescent swimmers...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28732462/exploring-general-purpose-protein-features-for-distinguishing-enzymes-and-non-enzymes-within-the-twilight-zone
#11
Yasser B Ruiz-Blanco, Guillermin Agüero-Chapin, Enrique García-Hernández, Orlando Álvarez, Agostinho Antunes, James Green
No abstract text is available yet for this article.
July 21, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28718069/neurological-involvement-in-patients-with-acute-recent-hiv-1-infection-a-case-control-study
#12
Juan Ambrosioni, Francisca Artigues, David Nicolás, Judit Peñafiel, Fernando Agüero, Christian Manzardo, María Mar Mosquera, Sonsoles Sánchez-Palomino, Elisa De Lazzari, María A Marcos, Montserrat Plana, José M Miró
Primary HIV-1 infection is a relevant period for its virological and epidemiological consequences. Most patients present a symptomatic disease that can be potentially serious, but neurological involvement during primary HIV-1 infection has been poorly studied. The aim of this study was to describe the characteristics and outcomes of primary HIV-1 infection patients presenting neurological symptoms and to compare them with primary HIV-1 infection patients without neurological involvement. Retrospective case-control study (1:3) comparing primary HIV-1 infection patients with and without neurological involvement enrolled in the Acute/Recent Hospital Clinic PHI Cohort between 1997 and 2016...
July 17, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28715897/hepatic-abscesses-secondary-to-a-foreign-body-in-the-common-bile-duct
#13
Laura Carballo Rodríguez, Inmaculada Ruiz Montesinos, Raúl Jiménez Agüero, Adolfo Beguiristain Gómez
Hepatic abscesses subsequent to a gastrointestinal perforation after the ingestion of a foreign body are rare, even more so if the perforation passes through the gastric antrum to the common bile duct. We present the case of a 75-year-old male who had been suffering from fever, discomfort and weakness for a week.
July 18, 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28687712/dynamic-edematous-response-of-the-human-heart-to-myocardial-infarction-implications-for-assessing-myocardial-area-at-risk-and-salvage
#14
Rodrigo Fernández-Jiménez, Manuel Barreiro-Pérez, Ana Martin-García, Javier Sánchez-González, Jaume Agüero, Carlos Galán-Arriola, Jaime García-Prieto, Elena Díaz-Pelaez, Pedro Vara, Irene Martinez, Ivan Zamarro, Beatriz Garde, Javier Sanz, Valentin Fuster, Pedro L Sánchez, Borja Ibanez
Background -Clinical protocols aimed to characterize the post-myocardial infarction (MI) heart by cardiac magnetic resonance (CMR) need to be standardized to take account of dynamic biological phenomena evolving early after the index ischemic event. Here we evaluated the time-course of edema reaction in ST-segment elevation MI (STEMI) patients by CMR and assessed its implications for myocardium-at-risk (MaR) quantification both in patients and in a large animal model. Methods -A total of 16 anterior STEMI patients successfully treated by primary angioplasty and 16 matched controls were prospectively recruited...
July 7, 2017: Circulation
https://www.readbyqxmd.com/read/28677981/physical-activity-exercise-and-sport-practice-to-fight-against-youth-and-childhood-obesity
#15
Exernet Red Española de Investigación En Ejercicio Físico y Salud, Germán Vicente-Rodríguez, Pedro J Benito, José A Casajús, Ignacio Ara, Susana Aznar, Manuel J Castillo, Cecilia Dorado, Alejandro González-Agüero, Javier González-Gallego, Marcela González-Gross, Luis Gracia-Marco, Ángel Gutiérrez, Narcis Gusi, David Jiménez-Pavón, Alejandro Lucía, Sara Márquez, Luis Moreno, Francisco B Ortega, José Antonio De Paz, Jonatan R Ruiz, José Antonio Serrano, Josep A Tur, Jara Valtueña
El propósito del presente documento es proponer desde el grupo de expertos en ejercicio físico y salud de EXERNET (Red Española de Investigación en Ejercicio Físico y Salud) una serie de recomendaciones sobre la práctica de la actividad física y deportiva que a nivel individual, familiar e institucional ayuden a prevenir y tratar la obesidad infantil y juvenil, basadas en la evidencia científica actual.
December 7, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28669186/volatile-compound-and-gene-expression-analyses-reveal-temporal-and-spatial-production-of-lox-derived-volatiles-in-pepino-solanum-muricatum-aiton-fruit-and-lox-specificity
#16
Carolina Contreras, Wilfried Schwab, Mechthild Mayershofer, Mauricio González-Agüero, Bruno G Defilippi
Lipoxygenase (LOX) is an important contributor to aroma compounds in most fresh produce; however, little is known about the LOX pathway in pepino (Solanum muricatum Aiton) fruit. We explored the LOX aroma compounds produced by the flesh and the peel and identified eight putative LOX genes expressed in both tissues during fruit growth and development during two consecutive seasons. This study shows that pepino produces C5, C6, and C9 LOX-derived compounds. Odorant C9 volatiles were produced during immature stages with a concomitant decrease when the fruit ripens, whereas C5 and C6 compounds were formed throughout ripening...
July 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28666201/screening-for-generalized-anxiety-disorder-in-spanish-primary-care-centers-with-the-gad-7
#17
Roger Muñoz-Navarro, Antonio Cano-Vindel, Juan Antonio Moriana, Leonardo Adrián Medrano, Paloma Ruiz-Rodríguez, Laura Agüero-Gento, Mónica Rodríguez-Enríquez, María Rosa Pizà, Jose Ignacio Ramírez-Manent
The aim of the study was to determine the criterion validity of a computerized version of the General Anxiety Disorder-7 (GAD-7) questionnaire to detect general anxiety disorder in Spanish primary care centers. A total of 178 patients completed the GAD-7 and were administered the Composite International Diagnostic Interview (CIDI) for DSM-IV Axis I Disorders, which was used as a reference standard. Sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios were calculated...
June 12, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28634575/association-between-plasmatic-ceramides-profile-and-ast-alt-ratio-c14-0-ceramide-as-predictor-of-hepatic-steatosis-in-adolescents-independently-of-obesity
#18
Jorge Maldonado-Hernández, Gabriela E Saldaña-Dávila, Mónica I Piña-Aguero, Benjamín A Núñez-García, Mardia G López-Alarcón
OBJECTIVE: To assess the association between plasma ceramides and hepatic steatosis (HS) in adolescents, independently of obesity. MATERIALS AND METHODS: Ninety-four adolescents from two previous studies conducted and published by our crew were included. Study subjects were stratified in three groups: normal weight (n = 18), obesity (n = 34), and obesity + HS (n = 42). The presence of HS was defined when ALT/AST ratio was <1. Ceramides subspecies (C14:0, C16:0, C18:0, C24:0, and C24:1) were determined by LC/MS...
2017: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28627199/hand-span-influences-optimal-grip-span-in-adolescents-with-down-syndrome
#19
José Antonio Casajús, Germán Vicente-Rodríguez, Alejandro González-Agüero, Ángel Matute-Llorente
INTRODUCTION: The hand grip strength test provides useful and reliable information about overall health. Different studies have investigated the optimal grip span for determining maximal hand grip strength in different populations such as adults, adolescents and children without disabilities. OBJECTIVE: To ascertain whether there is an optimal grip span for determining maximal hand grip strength in adolescents with Down syndrome (DS). METHODS: Twenty-seven right-handed youths with DS (seven females) aged 15...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28627186/%C3%A3-ndice-glic%C3%A3-mico-carga-glic%C3%A3-mica-e-insulina-posprandial-a-dos-f%C3%A3-rmulas-isogluc%C3%A3-dicas-con-distintos-edulcorantes-y-fibra-en-adultos-sanos-y-diab%C3%A3-ticos-tipo-2
#20
Lissé Angarita Dávila, José López Miranda, Daniel Aparicio Camargo, Karla Parra Zuleta, Maria Uzcátegui González, Virginia Céspedes Nava, Samuel Durán Agüero, Nadia Reyna Villasmil
Objetivo: el objetivo de este estudio fue comparar el índice glicémico (IG), la carga glicémica (CG) y la insulina posprandial de dos fórmulas isoglucídicas con distintos edulcorantes y fibra en adultos sanos y diabéticos tipo 2 (DM2).Metodología: en este estudio aleatorizado, cruzado y doble ciego, once sujetos sanos y seis diabéticos consumieron dos fórmulas en cuatro ocasiones (Glucerna SR® Laboratorios Abbott C.A [FG] y Enterex Diabetic®, Victus, C.A [FE], edulcoradas con fructosa y sucralosa respectivamente, con distintas fuentes de fibra), además de solución glucosada (SG) en una ocasión...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
keyword
keyword
103406
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"