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Cervico uterine cancer

Primoz Petric, Christian Kirisits
PURPOSE: Magnetic resonance imaging (MRI) is the gold standard for image guided adaptive brachytherapy (BT) of cervical cancer. Ultrasound is an attractive alternative with reasonable costs and high soft tissue depiction quality. This technical note aims to demonstrate the proof of principle for use of TRAns Cervical Endosonography with rotating transducer in the context of brachytherapy (TRACE BT). MATERIAL AND METHODS: TRACE BT presentation is based on a single stage IIB cervical cancer patient...
June 2016: Journal of Contemporary Brachytherapy
Víctor Manuel Vargas-Hernández, Víctor Manuel Vargas-Aguilar, José María Tovar-Rodríguez
Cervico-uterine cancer screening with cytology decrease incidence by more than 50%. The cause of this cancer is the human papilloma virus high risk, and requires a sensitive test to provide sufficient sensitivity and specificity for early detection and greater interval period when the results are negative. The test of the human papilloma virus high risk, is effective and safe because of its excellent sensitivity, negative predictive value and optimal reproducibility, especially when combined with liquid-based cytology or biomarkers with viral load, with higher sensitivity and specificity, by reducing false positives for the detection of cervical intraepithelial neoplasia grade 2 or greater injury, with excellent clinical benefits to cervical cancer screening and related infection of human papilloma virus diseases, is currently the best test for early detection infection of human papillomavirus and the risk of carcinogenesis...
September 2015: Cirugia y Cirujanos
Yolanda Terán-Figueroa, Patricia Muñiz-Carreón, Monserrat Fernandez Moya, Sergio Galán-Cuevas, Nuri Noyola-Range, Sandra Olimpia Gutiérrez-Enríquez, Julio Alejandro Ortiz-Valdez, Aurelio Cruz-Valdez
BACKGROUND: Cervical cancer is caused by high-risk HPV, a sexually transmitted virus. In Mexico, this disease represents a public health problem. San Luis Potosi is located within ten states with the highest rates in the country. Indigenous women of Mexico will likely to develop cervical cancer due to inequality in access to health services and their determinants. Epidemiological studies can be supported by investigations of diverse geographical nature to undertake the identification and analysis of spatial patterns of disease...
March 2015: Ginecología y Obstetricia de México
Erin Moses, Heather N Pedersen, Sheona M Mitchell, Musa Sekikubo, David Mwesigwa, Joel Singer, Christine Biryabarema, Josaphat K Byamugisha, Deborah M Money, Gina S Ogilvie
OBJECTIVES: To compare two cervical cancer screening methods: community-based self-collection of high-risk human papillomavirus (HR-HPV) testing and visual inspection with acetic acid (VIA). METHODS: Pilot randomised controlled trial of 500 women aged 30-65 in the community of Kisenyi, Uganda. Women randomised to self-collection-based HR-HPV testing provided a cervico-vaginal swab for HR-HPV, and results were provided by phone after laboratory testing. Women who tested HPV positive were referred for VIA at the local health unit...
October 2015: Tropical Medicine & International Health: TM & IH
Viola M J Verhoef, Daniëlle A M Heideman, Folkert J van Kemenade, Lawrence Rozendaal, Remko P Bosgraaf, Albertus T Hesselink, Ruud L M Bekkers, Leon F A G Massuger, Renske D M Steenbergen, Peter J F Snijders, Johannes Berkhof, Chris J L M Meijer
OBJECTIVES: Methylation marker analysis using bi-marker panel MAL/miR-124-2 is a promising triage test for identifying cervical (pre)cancer in high-risk human papillomavirus (hrHPV) positive women. Bi-marker panel MAL/miR-124-2 can be applied directly on self-sampled cervico-vaginal material and its sensitivity is non-inferior to that of cytology, yet at the cost of more colposcopy referrals. Our objective was to increase specificity of MAL/miR-124-2 methylation analysis by varying the assay thresholds and adding HPV16/18 genotyping...
October 2014: Gynecologic Oncology
Francesco Sopracordevole, Giuseppe Chiossi, Maggiorino Barbero, Paolo Cristoforoni, Bruno Ghiringhello, Antonio Frega, Francesca Tortolani, Fausto Boselli, Nicolò Clemente, Andrea Ciavattini
AIM: To assess the efficacy and safety of conservative surgical approach for microinvasive cervical cancer with regards to cone margins status and lymph vascular space invasion (LVSI). PATIENTS AND METHODS: This was a multicentre retrospective cohort study of 153 women diagnosed with microinvasive cervical cancer over a 10 years period (1993-2003). RESULTS: In conservatively-treated women (n=80), neither cancer mortality nor disease relapse after 184...
August 2014: Anticancer Research
A Boers, R P Bosgraaf, R W van Leeuwen, E Schuuring, D A M Heideman, L F A G Massuger, V M J Verhoef, J Bulten, W J G Melchers, A G J van der Zee, R L M Bekkers, G B A Wisman
BACKGROUND: Primary high-risk human papillomavirus (hrHPV) testing in cervical cancer screening shows relatively low specificity, which makes triage testing necessary. In this study, DNA methylation analysis was compared with cytology for triage testing in hrHPV-positive women. Moreover, feasibility of DNA methylation analysis directly on brush-based self-sampled specimens was assessed. METHODS: Non-responding women from population-based screening were invited to self-collect a cervico-vaginal specimen for hrHPV testing; hrHPV-positive women were referred to a physician for triage liquid-based cytology...
September 9, 2014: British Journal of Cancer
A T Hesselink, D A M Heideman, R D M Steenbergen, M Gök, F J van Kemenade, S M Wilting, J Berkhof, C J L M Meijer, P J F Snijders
Methylation markers were studied for their suitability to triage human papillomavirus (HPV)-positive women by testing self-collected cervico-vaginal lavage specimens. For this purpose, we analyzed 355 hrHPV-positive self-collected specimens with three methylation markers, that is, CADM1-m18, MAL-m1 and miR-124-2 by quantitative methylation-specific PCR. The areas under the receiver-operating characteristic (ROC) curve for end-point cervical intraepithelial neoplasia grade 3 or worse (CIN3+) were 0.637 for CADM1-m18, 0...
August 15, 2014: International Journal of Cancer. Journal International du Cancer
A T Hesselink, J Berkhof, M L van der Salm, A P van Splunter, T H Geelen, F J van Kemenade, M G B Bleeker, D A M Heideman
The HPV-Risk assay is a novel real-time PCR assay targeting the E7 region of 15 high-risk human papillomavirus (HPV) types (i.e., HPV16, -18, -31, -33, -35, -39, -45, -51, -52, -56, -58, -59, -66, -67, and -68), and provides additional genotype information for HPV16 and HPV18. This study evaluated the clinical performance and reproducibility of the HPV-Risk assay with cervical scraping specimens and its utility with self-collected (cervico)vaginal specimens. The clinical performance of the HPV-Risk assay for cervical intraepithelial neoplasia of grade 2 or worse (CIN2+) with cervical scraping specimens was evaluated by a noninferiority analysis, relative to high-risk HPV GP5+/6+ PCR, following international guidelines for HPV test requirements for cervical cancer screening...
March 2014: Journal of Clinical Microbiology
S M Shahida, K Saha, K A Banu, M A Islam
This population based cross sectional study was carried out in Muktagacha Upazilla Health Complex, Mymensingh, Bangladesh during the period of 26th to 28th June, 2012. The objective was to create awareness, to find out the precancerous lesion of cervix and to evaluate the effectiveness of this approach for prevention of cervical carcinoma. Women who were married and between 30-60 years and also women of below 30 years (who were married below the age of 18) were included in this study. All pregnant women were excluded from this study...
October 2013: Mymensingh Medical Journal: MMJ
Robin C Vanderpool, Maudella G Jones, Lindsay R Stradtman, Jennifer S Smith, Richard A Crosby
OBJECTIVE: Innovative screening methods such as self-testing for human papillomavirus (HPV) may alleviate barriers to cervical cancer screening. The purpose of this exploratory study was to determine whether Appalachian Kentucky women would be amenable to self-collecting a cervico-vaginal specimen for HPV testing. METHODS: Women aged 30-64 who were overdue for guideline-recommended cervical cancer screening were recruited from a primary care clinic in southeastern Kentucky...
March 2014: Gynecologic Oncology
Laura Ortega-Cervantes, Aurora Elizabeth Rojas-García, María de Lourdes Robledo-Marenco, Briscia Socorro Barrón-Vivanco, Manuel Iván Girón-Pérez, Verónica Vallejo-Ruiz, Juan Fernando López-Flores, Agustín Carrillo-Cortez, David Cantú-De León, Amelia Rodríguez-Trejo, Irma Martha Medina-Díaz
BACKGROUND: The incidences of breast cancer (BC) and cervico-uterine cancer (CC) vary widely from country to country. In Mexico, BC mortality has doubled in the last 20 years to become the second leading cause of death for women aged 30 to 54 years. CC is the most common cause of death from neoplasia in women over 25 years old. In 2006, the state of Nayarit had one of the highest mortality rates for these types of cancers in Mexico. OBJECTIVE: To analyze and characterize the current demographics and morbidities associated with BC and CC in the state of Nayarit...
May 2013: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Sueli Aparecida Batista Stabile, Dilson Henrique Ramos Evangelista, Valdely Helena Talamonte, Umberto Gazi Lippi, Reginaldo Guedes Coelho Lopes
OBJECTIVE: To compare two oncotic cervical cytology techniques, the conventional and the liquid-based cytology, in low risk patients for uterine cervical cancer. METHODS: Comparative prospective study with 100 patients who came to their annual gynecological exam, and were submitted simultaneously to both techniques. We used the McNemar test, with a significance level of p < 0.05 to compare the results obtained related to adequacy of the smear quality, descriptive diagnosis prevalence, guided biopsy confirmation and histology...
October 2012: Einstein
Kimberly L Levinson, Carolina Abuelo, Jorge Salmeron, Eunice Chyung, Jing Zou, Suzanne E Belinson, Guixiang Wang, Carlos Santos Ortiz, Carlos Santiago Vallejos, Jerome L Belinson
OBJECTIVE: This study utilized a combination of HPV self-sampling, iFTA elute specimen cards, and long distance transport for centralized processing of specimens to determine the feasibility of large-scale screening in remote and transient populations. METHODS: This study was performed in two locations in Peru (Manchay and Iquitos). The "Just For Me" cervico-vaginal brush and iFTA elute cards were used for the collection and transport of specimens. Samples were shipped via FedEx to China and tested for 14 types of high-risk HPV using PCR based MALDI-TOF...
May 2013: Gynecologic Oncology
Istéfani D Silva, Yara C N Muniz, Millena C P S Sousa, Karla R Silva, Erick C Castelli, José C G Filho, Ana P Osta, Maria I M Lima, Renata T Simões
Besides HPV infection, the progression to cervical cancer also depends on the host immune response. HLA-G molecules are involved in the inhibition of cell-mediated immune responses and may permit the development of an infection in the female cervical tract. The aim of this study was to explore the possible influence of the two HLA-G polymorphisms located on the 3'UTR on the susceptibility to cervical cancer and risk factors in Brazilian patients. Polymorphism analysis (14 bp In/Del and +3142C/G) was performed by PCR...
April 2013: Human Immunology
Peter J F Snijders, Viola M J Verhoef, Marc Arbyn, Gina Ogilvie, Silvia Minozzi, Rita Banzi, Folkert J van Kemenade, Daniëlle A M Heideman, Chris J L M Meijer
This review elaborates on the accuracy and feasibility of human papillomavirus (HPV) self-sampling, i.e., offering self-sampling of (cervico-)vaginal cell material by women themselves in nonclinical settings for high-risk HPV (hrHPV) detection in the laboratory, for cervical screening. To that end a bibliographic database search (PubMed) was performed to identify studies (published between January 1992 and January 2012) that compared clinical accuracy of HPV testing on self-sampled material with that of cytology or HPV testing on clinician-taken samples, and studies comparing response to offering HPV self-sampling with a recall invitation...
May 15, 2013: International Journal of Cancer. Journal International du Cancer
Maria Benevolo, Antonio Musio, Amina Vocaturo, Maria Gabriella Donà, Francesca Rollo, Irene Terrenato, Mariantonia Carosi, Edoardo Pescarmona, Giuseppe Vocaturo, Marcella Mottolese
BACKGROUND: Claspin is a nuclear protein involved in DNA replication and damage response and is a key mediator for the S-phase checkpoint. Claspin expression is significantly high in several human solid tumors. Furthermore, high levels of claspin have been found in cervical cancer cell lines. Nevertheless, no data are available regarding claspin expression in cervical tissues. METHODS: In order to investigate whether claspin immunoreactivity is related to the lesion severity and High-Risk (HR) HPV infection, we analyzed claspin expression by immunohistochemistry in a series of cervical biopsies which represent the steps occurring during cervical carcinogenesis (normal tissues, Cervical Intraepithelial Neoplasias 1, 2 and 3, Squamous Cell Carcinomas)...
2012: Journal of Translational Medicine
Su-Jin Shin, Kyu-Rae Kim, Dong-Eun Song, Jae Y Ro, Kun-Young Kong, Shin-Wha Lee, Joo-Hyun Nam
PURPOSE: Histological assessment of parametrial invasion in uterine cervical cancer is often subjective due to the parametrium being a loosely defined structure without apparent definitive landmarks. This study defines a precise and consistent histological landmark for the parametrium. METHODS: Based on study of cervico-parametrial junctions in 22 type III radical hysterectomy specimens from FIGO stage IB/IIA patients, three candidate histological landmarks were tested for ease in determination and reliability in 66 hysterectomy specimens with FIGO stage IIB tumors...
March 2012: Gynecologic Oncology
R Popovici, E Anton, G Costăchescu, Gh Costăchescu
UNLABELLED: The breast cancer is the most frequent malignancy in women over 60 years of age in the developed countries and it represents the second frequent cause of death through malignancies in women. MATERIAL AND METHOD: The study was performed on 63 women over 60 years old diagnosed with breast cancer in an one year period (2006) in our service. The aim of the study is to establish the clinical particularities and the optimal therapeutically management of this disease on elderly women...
October 2010: Revista Medico-chirurgicală̆ a Societă̆ţ̜ii de Medici ş̧i Naturaliş̧ti Din Iaş̧i
Mădălina Boşoteanu, C Boşoteanu, Mariana Deacu, Mariana Aşchie
Romania has supremacy in terms of European statistical indicators of cervical cancer, a fact attested by the studies made by international organizations. The present study is based on cytological evaluation of a group of 9269 cervico-vaginal smears, segregated in various groups that were monitored by standard diagnostic and therapeutic protocols, attitude based on an excellent collaboration with the gynecologist. This cooperation led to the elaboration of a set of protocols for follow-up of patients assessed by Babes-Papanicolaou test, in order to assure an adequate management for all cervical lesions...
2011: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
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