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https://www.readbyqxmd.com/read/27913732/a-hydantoin-isoform-of-cyclic-n6-threonylcarbamoyladenosine-ct6a-is-present-in-trnas
#1
Michal Matuszewski, Jakub Wojciechowski, Kenjyo Miyauchi, Zofia Gdaniec, Wojciech M Wolf, Tsutomu Suzuki, Elzbieta Sochacka
N(6)-Threonylcarbamoyladenosine (t(6)A) and its derivatives are universally conserved modified nucleosides found at position 37, 3' adjacent to the anticodon in tRNAs responsible for ANN codons. These modifications have pleiotropic functions of tRNAs in decoding and protein synthesis. In certain species of bacteria, fungi, plants and protists, t(6)A is further modified to the cyclic t(6)A (ct(6)A) via dehydration catalyzed by TcdA. This additional modification is involved in efficient decoding of tRNA(Lys) Previous work indicated that the chemical structure of ct(6)A is a cyclic active ester with an oxazolone ring...
December 2, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27807156/subcutaneous-infusion-of-fluids-for-hydration-or-nutrition-a-review
#2
REVIEW
Riccardo Caccialanza, Thierry Constans, Paolo Cotogni, Gary P Zaloga, Alessandro Pontes-Arruda
Subcutaneous infusion, or hypodermoclysis, is a technique whereby fluids are infused into the subcutaneous space via small-gauge needles that are typically inserted into the thighs, abdomen, back, or arms. In this review, we provide an overview of the technique, summarize findings from studies that have examined the use of subcutaneous infusion of fluids for hydration or nutrition, and describe the indications, advantages, and disadvantages of subcutaneous infusion. Taken together, the available evidence suggests that, when indicated, subcutaneous infusion can be effective for administering fluids for hydration or nutrition, with minimal complications, and has similar effectiveness and safety to the intravenous route...
November 2, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27802855/a-remarkable-case-of-rhabdomyolysis-associated-with-ingestion-of-energy-drink-neon-volt
#3
Praneet S Iyer, Rishitha Yelisetti, Varun Miriyala, Waqas Siddiqui, Anand Kaji
Rhabdomyolysis is defined as a syndrome characterized by muscle necrosis and the release of intracellular muscle constituents into the circulation. We present a case of a 35-year-old male who exercised for 2 h after ingesting energy drink and subsequently presented with rhabdomyolysis. After excluding common and uncommon causes of rhabdomyolysis, we reached the conclusion that the likely cause was the ingestion of energy drink 'NEON VOLT' in a setting of mild dehydration. Increasing physical activity and intense exercise is becoming a trend in many countries, due to its many health-related benefits such as prevention of obesity...
2016: Journal of Community Hospital Internal Medicine Perspectives
https://www.readbyqxmd.com/read/27800480/post-exercise-rehydration-effect-of-consumption-of-beer-with-varying-alcohol-content-on-fluid-balance-after-mild-dehydration
#4
Annemarthe H C Wijnen, Jora Steennis, Milène Catoire, Floris C Wardenaar, Marco Mensink
PURPOSE: The effects of moderate beer consumption after physical activity on rehydration and fluid balance are not completely clear. Therefore, in this study, we investigated the effect of beer consumption, with varying alcohol content, on fluid balance after exercise-induced dehydration. METHODS: Eleven healthy males were included in this cross over study (age 24.5 ± 4.7 years, body weight 75.4 ± 3.3 kg, VO2max 58.3 ± 6.4 mL kg min(-1)). Subjects exercised on a cycle ergometer for 45 min at 60% of their maximal power output (Wmax) until mild dehydration (1% body mass loss)...
2016: Frontiers in Nutrition
https://www.readbyqxmd.com/read/27788840/dilute-apple-juice-superior-to-electrolyte-solution-in-mild-dehydration
#5
Shai Ashkenazi
No abstract text is available yet for this article.
November 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27787335/cardiovascular-drift-during-training-for-fitness-in-metabolic-syndrome-patients
#6
Felix Morales-Palomo, Miguel Ramirez-Jimenez, Juan Fernando Ortega, Jesus Garcia Pallares, Ricardo Mora-Rodriguez
PURPOSE: The health benefits of a training program are largely influenced by the exercise dose and intensity. We sought to determine if during a training bout of continuous vs. interval exercise the workload needs to be reduced to maintain the prescribed target heart rate. METHODS: Fourteen obese (31±4 kg·m) middle-age (57±8 y) individuals with metabolic syndrome, underwent two exercise training bouts matched by energy expenditure (i.e., 70±5 min of continuous exercise; CE or 45 min of interval exercise; HIIT)...
October 27, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27768517/mild-dehydration-does-not-influence-performance-or-skeletal-muscle-metabolism-during-simulated-ice-hockey-exercise-in-men
#7
Matthew S Palmer, George Jf Heigenhauser, MyLinh Duong, Lawrence L Spriet
This study determined whether mild dehydration influenced skeletal muscle glycogen use, core temperature or performance during high-intensity, intermittent cycle-based exercise in ice hockey players vs. staying hydrated with water. Eight males (21.6 ± 0.4 yr, 183.5 ± 1.6 cm, 83.9 ± 3.7 kg, 50.2 ± 1.9 mL·kg(-1)·min(-1)) performed two trials separated by 7 days. The protocol consisted of 3 periods (P) containing 10 x 45-second cycling bouts at ~133% VO2max, followed by 135 seconds of passive rest. Subjects drank no fluid and dehydrated during the protocol (NF), or maintained body mass by drinking WATER...
October 21, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27731292/treatments-for-hyperemesis-gravidarum-and-nausea-and-vomiting-in-pregnancy-a-systematic-review-and-economic-assessment
#8
Amy O'Donnell, Catherine McParlin, Stephen C Robson, Fiona Beyer, Eoin Moloney, Andrew Bryant, Jennifer Bradley, Colin Muirhead, Catherine Nelson-Piercy, Dorothy Newbury-Birch, Justine Norman, Emma Simpson, Brian Swallow, Laura Yates, Luke Vale
BACKGROUND: Nausea and vomiting in pregnancy (NVP) affects up to 85% of all women during pregnancy, but for the majority self-management suffices. For the remainder, symptoms are more severe and the most severe form of NVP - hyperemesis gravidarum (HG) - affects 0.3-1.0% of pregnant women. There is no widely accepted point at which NVP becomes HG. OBJECTIVES: This study aimed to determine the relative clinical effectiveness and cost-effectiveness of treatments for NVP and HG...
October 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27699154/methylmalonyl-coa-epimerase-deficiency-a-new-case-with-an-acute-metabolic-presentation-and-an-intronic-splicing-mutation-in-the-mcee-gene
#9
Paula J Waters, Fanny Thuriot, Joe T R Clarke, Serge Gravel, David Watkins, David S Rosenblatt, Sébastien Lévesque
Methylmalonyl-coA epimerase (MCE) follows propionyl-coA carboxylase and precedes methylmalonyl-coA mutase in the pathway converting propionyl-coA to succinyl-coA. MCE deficiency has previously been described in six patients, one presenting with metabolic acidosis, the others with nonspecific neurological symptoms or asymptomatic. The clinical significance and biochemical characteristics of this rare condition have been incompletely defined. We now describe a patient who presented acutely at 5 years of age with vomiting, dehydration, confusion, severe metabolic acidosis and mild hyperammonemia...
December 2016: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/27686522/association-of-rotavirus-strains-and-severity-of-gastroenteritis-in-indian-children
#10
Tarun Saluja, Mandeep S Dhingra, Shiv D Sharma, Madhu Gupta, Ritabrata Kundu, Sonali Kar, Ashok K Dutta, Maria D P Silveira, Jai V Singh, Veena G Kamath, Anurag Chaudhary, Venkateswara Rao, Mandyam D Ravi, Kesava Murthy, Rajesh Arumugam, Annick Moureau, Rajendra Prasad, Badri N Patnaik
Rotavirus is the leading cause of severe and dehydrating diarrhea in children aged under 5 years. We undertook this hospital-based surveillance study to examine the possible relationship between the severity of diarrhea and the various G-group rotaviruses circulating in India. Stool samples (n = 2,051) were systematically collected from 4,711 children aged < 5 years admitted with severe acute gastroenteritis to 12 medical school centers from April 2011 to July 2012. Rotavirus testing was undertaken using a commercially available enzyme immunoassay kit for the rotavirus VP6 antigen (Premier Rotaclone Qualitative ELISA)...
September 29, 2016: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/27660600/calcium-pyrophosphate-dihydrate-crystal-deposition-disease-simulating-osteoarthrosis-of-the-knee-a-case-report
#11
Stefanie A Pawelek, Jennifer D Illes, John A Taylor
OBJECTIVE: The purpose of this case report is to describe a case where calcium pyrophosphate dehydrate crystal deposition disease (CPPD) simulated osteoarthritis of the knee. CLINICAL FEATURES: A 78-year-old woman had a 2-week history of severe right knee pain accompanied by mild swelling. The onset was sudden and did not involve a history of trauma or previous injury to the right knee. Inspection and palpation revealed pain along the medial joint line and marked difficulty ambulating...
September 2016: Journal of Chiropractic Medicine
https://www.readbyqxmd.com/read/27649622/construction-of-3-fold-interpenetrated-three-dimensional-metal-organic-frameworks-of-nickel-ii-for-highly-efficient-capture-and-conversion-of-carbon-dioxide
#12
Bharat Ugale, Sandeep Singh Dhankhar, C M Nagaraja
A series of three new isostructural metal-organic frameworks (MOFs) of nickel(II), [{Ni(muco)(bpa)(2H2O)}·2H2O] (1), [{Ni(muco)(bpe)(2H2O)}·2.5H2O] (2), and [{Ni(muco)(azopy)(2H2O)}·2H2O] (3) [where muco = trans,trans-muconate dianion, bpa = 1,2-bis(4-pyridyl)ethane, bpe = 1,2-bis(4-pyridyl)ethylene, and azopy = 4,4'-bis(azobipyridine)], have been synthesized and characterized by single-crystal X-ray diffraction analysis and other physicochemical methods. Compounds 1-3 exhibit an interesting 3-fold-interpenetrated three-dimensional pillar-layered framework structure constituted of 4-coordinating (4-c) Ni(II) nodes with {6(6)}-neb net topology...
October 3, 2016: Inorganic Chemistry
https://www.readbyqxmd.com/read/27645786/pharmacovigilance-of-miltefosine-in-treatment-of-visceral-leishmaniasis-in-endemic-areas-of-bihar-india
#13
Krishna Pandey, Vidyanand Ravidas, Niyamat A Siddiqui, Sanjay K Sinha, Rakesh B Verma, Tripurari P Singh, A C Dhariwal, R K Das Gupta, Pradeep Das
Miltefosine, the only oral drug for visceral leishmaniasis (VL), is being used as the first-line drug under the VL elimination program in the Indian subcontinent. Miltefosine is an oral drug which was used as a topical application for skin metastasis of breast cancer. It was found to be effective against Leishmania donovani The main adverse events (AE) reported previously with miltefosine use includes diarrhea, vomiting, and dehydration. Other AEs include, raised serum alanine transaminase/aspartate aminotransferase and renal parameters such as creatinine...
November 2, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27625114/efficient-synthesis-of-dimethyl-ether-from-methanol-in-a-bifunctional-zeolite-membrane-reactor
#14
Chen Zhou, Nanyi Wang, Yanan Qian, Xiaoxing Liu, Jürgen Caro, Aisheng Huang
A sandwich FAU-LTA zeolite dual-layer membrane has been developed and used as a catalytic membrane reactor for the synthesis of dimethyl ether (DME). In the top H-FAU layer with mild acidity, methanol is dehydrated to DME. The other reaction product, water, is removed in situ through a hydrophilic Na-LTA layer, which is located between the porous alumina support and the H-FAU top layer. The combination of mild acidity with the continuous removal of water results in high methanol conversion (90.9 % at 310 °C) and essentially 100 % DME selectivity...
October 4, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27584580/access-to-the-cinnoline-scaffold-via-rhodium-catalyzed-intermolecular-cyclization-under-mild-conditions
#15
Chao Song, Chen Yang, Feifei Zhang, Jinhu Wang, Jin Zhu
Herein, we report Rh(III)-catalyzed, N-amino (hydrazine)-directed C-H functionalization with α-diazo-β-ketoesters for access to the cinnoline scaffold. A diverse set of nondiscriminating conditions obtained for a highly efficient test transformation prompted use of a substrate-replacement technique for an in-depth search of experimental parameter space and pinpointing of the optimized conditions. A successive C-H activation/C-C coupling/intramolecular dehydration mechanistic sequence is proposed. The ability to perform gram-scale synthesis proves the synthetic utility of this simple, yet efficient, method...
September 16, 2016: Organic Letters
https://www.readbyqxmd.com/read/27546608/cold-hardiness-and-influences-of-hibernaculum-conditions-on-overwintering-survival-of-american-dog-tick-larvae
#16
Andrew J Rosendale, David W Farrow, Megan E Dunlevy, Alicia M Fieler, Joshua B Benoit
Understanding how ticks survive the multitude of stresses experienced during winter is integral to predicting population dynamics and transmission of tick-borne pathogens. The American dog tick (Dermacentor variabilis), a predominant vector of Rocky Mountain spotted fever, overwinters in any of its post-egg life stages. In this study, we characterized the cold tolerance of larval D. variabilis and examined the effect of various acclimatory conditions on cold hardiness. Cold-shock survival during 2h exposure to various subzero temperatures was assessed and a lower lethal temperature of -20°C and a 50% mortality temperature near -16°C was established...
October 2016: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/27503798/syntheses-of-pterocarpenes-and-coumestans-via-regioselective-cyclodehydration
#17
Maloy Nayak, Youngeun Jung, Ikyon Kim
A highly efficient synthetic route to pterocarpenes and coumestans is described. BCl3-mediated dehydrative cyclization of 1,3-diaryloxyacetones under mild conditions permitted regioselective ring closure to afford 3-((2-iodoaryloxy)methyl)benzofurans which were converted to the corresponding pterocarpenes by Pd-catalyzed intramolecular direct arylation. The subsequent benzylic oxidation led to coumestans. This sequence was applied to the formal syntheses of coumestrol and the proposed structure of plicadin as well as total syntheses of flemichapparins B and C...
September 14, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27496680/safety-and-efficacy-of-thalidomide-in-patients-with-poems-syndrome-a-multicentre-randomised-double-blind-placebo-controlled-trial
#18
Sonoko Misawa, Yasunori Sato, Kanako Katayama, Kengo Nagashima, Reiko Aoyagi, Yukari Sekiguchi, Gen Sobue, Haruki Koike, Ichiro Yabe, Hidenao Sasaki, Osamu Watanabe, Hiroshi Takashima, Masatoyo Nishizawa, Izumi Kawachi, Susumu Kusunoki, Yoshiyuki Mitsui, Seiji Kikuchi, Ichiro Nakashima, Shu-Ichi Ikeda, Nobuo Kohara, Takashi Kanda, Jun-Ichi Kira, Hideki Hanaoka, Satoshi Kuwabara
BACKGROUND: Polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome is a rare cause of demyelinating neuropathy, with multi-organ involvement characterised by plasma cell dyscrasia and VEGF overproduction. No treatments have been established for patients with POEMS syndrome who are not eligible for stem-cell transplantation. Thalidomide suppresses VEGF and plasma cell proliferation. We aimed to assess the safety and efficacy of thalidomide for the treatment of POEMS syndrome...
October 2016: Lancet Neurology
https://www.readbyqxmd.com/read/27465991/aging-associated-renal-disease-in-mice-is-fructokinase-dependent
#19
Carlos A Roncal-Jimenez, Takuji Ishimoto, Miguel A Lanaspa, Tamara Milagres, Ana Andres Hernando, Thomas Jensen, Makoto Miyazaki, Tomohito Doke, Takahiro Hayasaki, Takahiko Nakagawa, Shoichi Marumaya, David A Long, Gabriela E Garcia, Masanari Kuwabara, Laura G Sánchez-Lozada, Duk-Hee Kang, Richard J Johnson
Aging-associated kidney disease is usually considered a degenerative process associated with aging. Recently, it has been shown that animals can produce fructose endogenously, and that this can be a mechanism for causing kidney damage in diabetic nephropathy and in association with recurrent dehydration. We therefore hypothesized that low-level metabolism of endogenous fructose might play a role in aging-associated kidney disease. Wild-type and fructokinase knockout mice were fed a normal diet for 2 yr that had minimal (<5%) fructose content...
October 1, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27463219/extrapontine-myelinolysis-associated-with-severe-hypernatremia-in-infancy
#20
Ryoji Aoki, Tetsuji Morimoto, Yuno Takahashi, Hiroshi Saito, Tatsuo Fuchigami, Shori Takahashi
Extrapontine myelinolysis (EPM) is an uncommon disorder in children, with few pediatric cases reported to date. We report the first case of an infant with EPM without central pontine myelinolysis (CPM) presenting with severe hypernatremia. On admission, the infant had impaired consciousness, mild dehydration, and severe hypernatremia (190 mmol/L). The following day, the patient developed abnormal involuntary movements. Brain magnetic resonance imaging (MRI) confirmed EPM without CPM. He recovered without sequelae, and clinical examinations were within normal limits approximately 6 months after discharge...
September 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
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