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https://www.readbyqxmd.com/read/29334929/chronic-kidney-disease-in-sugarcane-workers-in-cameroon-a-cross-sectional-study
#1
Martin E Ekiti, Jean-Berthelot Zambo, Felix K Assah, Valirie N Agbor, Krystel Kekay, Gloria Ashuntantang
BACKGROUND: Agricultural workers especially in sugarcane plantations have a high risk of chronic kidney disease (CKD). Little is known about CKD among sugarcane plantation workers in Cameroon. This study sought to evaluate the prevalence and identify factors associated with CKD in sugarcane plantation workers in Cameroon. METHODS: We conducted an analytic cross-sectional study including 204 adult workers at the sugarcane plantation complex in Mbandjock, Cameroon; over 500 m above sea level...
January 15, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29298718/s737f-is-a-new-cftr-mutation-typical-of-patients-originally-from-the-tuscany-region-in-italy
#2
Vito Terlizzi, Antonella Miriam Di Lullo, Marika Comegna, Claudia Centrone, Elisabetta Pelo, Giuseppe Castaldo, Valeria Raia, Cesare Braggion
BACKGROUND: An increasing number of patients have been described as having a number of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) variants for which it lacks a clear genotype-phenotype correlation. We assesses the clinical features of patients bearing the S737F (p.Ser737Phe) CFTR missense variant and evaluated the residual function of CFTR protein on nasal epithelial cells (NEC). METHODS: A retrospective database was performed from individuals homozygous or compound heterozygous for the S737F variant followed in the Cystic Fibrosis (CF) Centre of Florence...
January 3, 2018: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29298060/an-acid-catalyzed-addition-and-dehydration-sequence-for-the-synthesis-of-heteroarylated-steroidal-dienes
#3
Tanner L Metz, Grace A Lutovsky, Levi M Stanley
Additions of heteroarenes to hormone steroids containing an α,β-unsaturated ketone are reported. Additions of a range of electron-rich heteroarene nucleophiles, including indoles, a pyrrole, and a thiophene, to a variety of commercially available steroids and subsequent dehydration occur to form 3-heteroarylated steroidal dienes in up to 93% yield. This atom-economical reaction sequence occurs under mild reaction conditions in the presence of catalytic bismuth triflate.
January 3, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29283373/stereoselective-synthesis-synthetic-and-pharmacological-application-of-monoterpene-based-1-2-4-and-1-3-4-oxadiazoles
#4
Tímea Gonda, Péter Bérdi, István Zupkó, Ferenc Fülöp, Zsolt Szakonyi
Stereoselective synthesis of monoterpene-based 1,2,4- and 1,3,4-oxadiazole derivatives was accomplished starting from α,β-unsaturated carboxylic acids, obtained by the oxidation of (-)-2-carene-3-aldehyde and commercially available (-)-myrtenal. 1,2,4-Oxadiazoles were prepared in two steps via the corresponding O-acylamidoxime intermediates, which then underwent cyclisation induced by tetrabutylammonium fluoride (TBAF) under mild reaction conditions. Stereoselective dihydroxylation in highly stereospecific reactions with the OsO₄/NMO (N-methylmorpholine N-oxide) system produced α,β-dihydroxy 1,2,4-oxadiazoles...
December 28, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29277553/water-intake-reverses-dehydration-associated-impaired-executive-function-in-healthy-young-women
#5
Nina S Stachenfeld, Cheryl A Leone, E Soibhan Mitchell, Eric Freese, Laura Harkness
INTRODUCTION: Healthy women do not always consume Recommended Daily Levels of fluid intake ad libitum. We hypothesized that 1) women lose≥1.0% BW during daily activities, 2) that mild body water loss impairs memory and executive function, 3) water intake to recommended daily levels will improve cognitive function. METHODS: We tested 12 women (26±5yr, 22.5±2.6kg/m2 BMI). Session 1 was a control (CON) session, during which subjects monitored their food and fluid intake (diary) and activity (Fitbit®)...
December 22, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29275215/uncovering-the-basis-of-viability-loss-in-desiccation-sensitive-trichilia-dregeana-seeds-using-differential-quantitative-protein-expression-profiling-by-itraq
#6
Anushka Moothoo-Padayachie, Angus Macdonald, Boby Varghese, Norman W Pammenter, Patrick Govender, Sershen
Recalcitrant seeds, unlike orthodox types, are desiccation sensitive and hence, cannot be stored using conventional seed storage methods In this study, relative changes of protein expression in T. dregeana seeds during desiccation and hydrated storage (a short- to medium-term storage method) were analysed to understand the basis of their desiccation- and storage-induced viability loss. Isobaric Tags for Relative and Absolute Quantitation (iTRAQ) were used to compare (selected) protein expression levels across fresh, partially dehydrated and stored seeds...
December 16, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29241618/appropriateness-of-clinical-severity-classification-of-new-who-childhood-pneumonia-guidance-a-multi-hospital-retrospective-cohort-study
#7
Ambrose Agweyu, Richard J Lilford, Mike English
BACKGROUND: Management of pneumonia in many low-income and middle-income countries is based on WHO guidelines that classify children according to clinical signs that define thresholds of risk. We aimed to establish whether some children categorised as eligible for outpatient treatment might have a risk of death warranting their treatment in hospital. METHODS: We did a retrospective cohort study of children aged 2-59 months admitted to one of 14 hospitals in Kenya with pneumonia between March 1, 2014, and Feb 29, 2016, before revised WHO pneumonia guidelines were adopted in the country...
January 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29236645/caterpillar-sign-in-infantile-hypertrophic-pyloric-stenosis
#8
Bruno Martinez-Leo, Luis M Garcia-Cabello
A 23-day-old male infant was brought to the emergency department because of nonbilious vomiting that had increased in frequency over a period of 5 days. Findings from the clinical examination were notable for mild dehydration and a possible olive-sized mass, approximately 2 cm in diameter, that was..
December 14, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29226676/metal-free-synthesis-of-unsymmetrical-ureas-and-carbamates-from-co2-and-amines-via-isocyanate-intermediates
#9
Yiming Ren, Sophie A L Rousseaux
A mild and metal-free synthesis of aryl isocyanates from arylamines under an atmosphere of CO2 has been developed. The carbamic acid intermediate, derived from the arylamine starting material and CO2 in the presence of DBU, is dehydrated by activated sulfonium reagents to generate the corresponding isocyanate. The latter can be detected by in situ IR and trapped by various amines and alcohols to make unsymmetrical ureas and carbamates, respectively. Dicarbamates can also be prepared in good yields via the mild dehydration of the corresponding dicarbamic acids...
December 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29201633/a-peculiar-case-of-asymptomatic-spontaneous-pneumomediastinum
#10
Trent Irwin, Mohit Rishi, Bishwas Upadhyay
Objective: To present a case of asymptomatic spontaneous pneumomediastinum and review available evidence-based workup and management. Case presentation: A young Caucasian adult male with a history of inhalational drug use was admitted to the internal medicine service for evaluation of dehydration and mild rhabdomyolysis. Patient had been on the run from the police and had spent the last days prior to presentation without food, water, or shelter. On admission, patient had no complaints, except for thirst...
2017: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29200226/green-synthesis-of-a-new-layered-aluminium-citraconate-crystal-structures-intercalation-behaviour-towards-h2o-and-in-situ-pxrd-studies-of-its-crystallisation
#11
Niclas Heidenreich, Alexandra Lieb, Norbert Stock, Helge Reinsch
A new Al-based layered MOF [Al2(OH)4(O2C-C3H4-CO2)]·nH2O denoted as CAU-15-Cit was synthesised under mild aqueous conditions. It exhibits a layered structure incorporating infinite chains of edge-sharing AlO6 polyhedra being interconnected by citraconate anions to arrange into layers, which are stacked in an AAA fashion (citraconic acid = methylmaleic acid = H2Cit, HO2C-C3H4-CO2H). The crystal structures of the hydrated and dehydrated MOF were determined ab initio from powder X-ray diffraction (PXRD) data...
December 4, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29197113/pyelonephritis-in-dogs-retrospective-study-of-47-histologically-diagnosed-cases-2005-2015
#12
J Bouillon, E Snead, J Caswell, C Feng, P Hélie, J Lemetayer
BACKGROUND: The clinicopathologic aspects of pyelonephritis have not been reported in companion animals. HYPOTHESIS/OBJECTIVES: To evaluate the prevalence of pyelonephritis diagnosed in dogs in a academic referral population, describe the clinical signs and the diagnostic test results in dogs with pyelonephritis, and identify concurrent disorders in order to determine potential risk factors for pyelonephritis. ANIMALS: Forty-seven dogs with a histopathologic diagnosis of pyelonephritis from the teaching hospitals of three Canadian veterinary colleges...
December 2, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29184212/oxytocin-receptor-expressing-neurons-in-the-parabrachial-nucleus-regulate-fluid-intake
#13
Philip J Ryan, Silvano I Ross, Carlos A Campos, Victor A Derkach, Richard D Palmiter
Brain regions that regulate fluid satiation are not well characterized, yet are essential for understanding fluid homeostasis. We found that oxytocin-receptor-expressing neurons in the parabrachial nucleus of mice (OxtrPBN neurons) are key regulators of fluid satiation. Chemogenetic activation of OxtrPBN neurons robustly suppressed noncaloric fluid intake, but did not decrease food intake after fasting or salt intake following salt depletion; inactivation increased saline intake after dehydration and hypertonic saline injection...
December 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29177054/increase-in-branched-chain-amino-acids-due-to-acidemia-in-neonatal-calves-with-diarrhoea
#14
Kenji Tsukano, Hiroki Inoue, Kazuyuki Suzuki
The aim of this study was to investigate the relationships between acid-base status and plasma branched-chain amino acids (BCAA) concentration in calves with diarrhoea for intravenous nutrition, especially with amino acid solution in calves with diarrhoea. Thirty-four Holstein calves aged 11.0±5.9 days old were enrolled in this study. In 10 of 34 calves exhibiting clinical signs of diarrhoea, severe dehydration and acidemia were observed (severe group: pH: 7.04±0.11, base excess (BE): -17.4±4.5) based on blood gas analysis...
2017: Veterinary Record Open
https://www.readbyqxmd.com/read/29161044/scalable-synthesis-of-trifluoromethylated-imidazo-fused-n-heterocycles-using-tfaa-and-trifluoroacetamide-as-cf3-reagents
#15
Gabriel Schäfer, Muhamed Ahmetovic, Stefan Abele
A scalable synthesis of trifluoromethylated imidazo-fused N-heterocyles from heterocyclic benzylamines using TFAA as trifluoromethylating reagent is presented. The reaction proceeds via intermediate benzylic N-trifluoroacetamides followed by dehydrative cyclization to the products. To further broaden the scope and practicality, a new method for the preparation of benzylic N-trifluoroacetamides via alkylation of trifluoroacetamide with benzyl (pseudo)halides was developed. Both methods proceed under mild conditions, and their symbiosis provides access to a wide range of novel CF3-heterocycles...
November 21, 2017: Organic Letters
https://www.readbyqxmd.com/read/29141761/leptospirosis-cases-infected-with-uncommon-serogroups-puerto-rico-2013-2015
#16
Hector Gorbea, Enid J Garcia-Rivera, Hilda Torres, Olga D Lorenzi, Aidsa Rivera, Renee L Galloway, Tyler M Sharp
Leptospirosis is an emerging bacterial zoonosis that is endemic but underrecognized throughout the tropics. Through prospective surveillance for acute febrile illness (AFI) among patients who presented to the emergency department of a hospital located in an urban region of Puerto Rico, four patients with laboratory-confirmed leptospirosis were identified. All patients had signs and symptoms of AFI, including fever, headache, and dehydration. Three patients had leukocytosis with thrombocytopenia and were admitted to the hospital...
November 6, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29124652/red-shift-in-the-spectrum-of-a-chlorophyll-species-is-essential-for-the-drought-induced-dissipation-of-excess-light-energy-in-a-poikilohydric-moss-bryum-argenteum
#17
Yutaka Shibata, Ahmed Mohamed, Koichiro Taniyama, Kentaro Kanatani, Makiko Kosugi, Hiroshi Fukumura
Some mosses are extremely tolerant of drought stress. Their high drought tolerance relies on their ability to effectively dissipate absorbed light energy to heat under dry conditions. The energy dissipation mechanism in a drought-tolerant moss, Bryum argenteum, has been investigated using low-temperature picosecond time-resolved fluorescence spectroscopy. The results are compared between moss thalli samples harvested in Antarctica and in Japan. Both samples show almost the same quenching properties, suggesting an identical drought tolerance mechanism for the same species with two completely different habitats...
November 9, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/29103272/first-case-of-canine-infection-with-hepatozoon-canis-apicomplexa-haemogregarinidae-in-the-republic-of-korea
#18
Seung-Joo Kwon, Yoon-Hee Kim, Hyun-Hee Oh, Ul-Soo Choi
This report describes a dog infected with Hepatozoon canis, the first canine infection in the Republic of Korea. A 2-year-old intact male Maltese dog presented with anorexia and depression. Physical examinations revealed mild dehydration and hyperthermia (39.8°C), and blood analysis showed pancytopenia. Diff-Quik staining of blood smear specimens showed the presence of ellipsoidal shaped structures (gamonts of H. canis) within a small number of neutrophils. Real-time PCR analysis using whole blood confirmed infection by H...
October 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/29062280/heat-and-dehydration-additively-enhance-cardiovascular-outcomes-following-orthostatically-stressful-calisthenics-exercise
#19
Ashley P Akerman, Samuel J E Lucas, Rajesh Katare, James D Cotter
Exercise and exogenous heat each stimulate multiple adaptations, but their roles are not well delineated, and that of the related stressor, dehydration, is largely unknown. While severe and prolonged hypohydration potentially "silences" the long-term heat acclimated phenotype, mild and transient dehydration may enhance cardiovascular and fluid-regulatory adaptations. We tested the hypothesis that exogenous heat stress and dehydration additively potentiate acute (24 h) cardiovascular and hematological outcomes following exercise...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29046194/the-role-of-intravenous-access-during-oral-food-challenges-in-food-protein-induced-enterocolitis-syndrome
#20
Laura E Pena, Danielle Guffey, Charles G Minard, Sara Anvari, Carla M Davis
BACKGROUND: Food protein-induced enterocolitis syndrome (FPIES) is a non-immunoglobulin E mediated food hypersensitivity syndrome characterized by profuse vomiting and diarrhea, which leads to lethargy, dehydration, and hypotension. Given the potential severity of reactions, resolution of FPIES is confirmed via oral food challenge (OFC) during which intravenous (IV) access is recommended to facilitate IV fluids (IVF) and steroid therapy. Risk factors for IV treatment are not well characterized...
November 1, 2017: Allergy and Asthma Proceedings:
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