keyword
MENU ▼
Read by QxMD icon Read
search

contag

keyword
https://www.readbyqxmd.com/read/29141657/local-estrogen-axis-in-the-human-bone-microenvironment-regulates-estrogen%C3%A2-receptor-positive%C3%A2-breast-cancer-cells
#1
Derek F Amanatullah, John S Tamaresis, Pauline Chu, Michael H Bachmann, Nhat M Hoang, Deborah Collyar, Aaron T Mayer, Robert B West, William J Maloney, Christopher H Contag, Bonnie L King
BACKGROUND: Approximately 70% of all breast cancers express the estrogen receptor, and are regulated by estrogen. While the ovaries are the primary source of estrogen in premenopausal women, most breast cancer is diagnosed following menopause, when systemic levels of this hormone decline. Estrogen production from androgen precursors is catalyzed by the aromatase enzyme. Although aromatase expression and local estrogen production in breast adipose tissue have been implicated in the development of primary breast cancer, the source of estrogen involved in the regulation of estrogen receptor-positive (ER+) metastatic breast cancer progression is less clear...
November 15, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29020448/preparation-of-tc99m-labeled-pseudomonas-bacteriophage-without-adversely-impacting-infectivity-or-biodistribution
#2
Derek Holman, Matthew P Lungren, Jonathan Hardy, Chris Contag, Francis Blankenberg
Bacteriophages (phages) are ubiquitous viruses which have adapted to infect and replicate within target bacteria, their only known hosts, in a strain specific fashion with minimal cross infectivity. The recent steep rise in antibiotic resistance throughout the world has renewed interest in adapting phages for the imaging and treatment of bacterial infection in humans. In this article, we describe the current limitations surrounding the radiolabeling of phage for the imaging and treatment of bacterial infection and methods to overcome these difficulties...
October 26, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28982129/the-tyrosine-kinase-inhibitor-imatinib-mesylate-suppresses-uric-acid-crystal-induced-acute-gouty-arthritis-in-mice
#3
Laurent L Reber, Philipp Starkl, Bianca Balbino, Riccardo Sibilano, Nicolas Gaudenzio, Stephan Rogalla, Steven Sensarn, Dongmin Kang, Harini Raghu, Jeremy Sokolove, William H Robinson, Christopher H Contag, Mindy Tsai, Stephen J Galli
Gouty arthritis is caused by the deposition of monosodium urate (MSU) crystals in joints. Despite many treatment options for gout, there is a substantial need for alternative treatments for patients unresponsive to current therapies. Tyrosine kinase inhibitors have demonstrated therapeutic benefit in experimental models of antibody-dependent arthritis and in rheumatoid arthritis in humans, but to date, the potential effects of such inhibitors on gouty arthritis has not been evaluated. Here we demonstrate that treatment with the tyrosine kinase inhibitor imatinib mesylate (imatinib) can suppress inflammation induced by injection of MSU crystals into subcutaneous air pouches or into the ankle joint of wild type mice...
2017: PloS One
https://www.readbyqxmd.com/read/28832465/in-reply
#4
Ruofan Yao, Katherine R Goetzinger, Sarah D Crimmins, Jerome N Kopelman, Stephen A Contag
No abstract text is available yet for this article.
September 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28631141/cell-labeling-with-magneto-endosymbionts-and-the-dissection-of-the-subcellular-location-fate-and-host-cell-interactions
#5
Kayla R Lee, Abdul Wakeel, Papia Chakraborty, Chandler S Foote, Lauren Kajiura, Joyce C Barrozo, Andrea C Chan, Alexey V Bazarov, Ryan Spitler, Peter M Kutny, Jim M Denegre, Rob A Taft, Joachim Seemann, Bradley W Rice, Christopher H Contag, Brian K Rutt, Caleb B Bell
PURPOSE: The purposes of this study are to characterize magneto-endosymbiont (ME) labeling of mammalian cells and to discern the subcellular fate of these living contrast agents. MEs are novel magnetic resonance imaging (MRI) contrast agents that are being used for cell tracking studies. Understanding the fate of MEs in host cells is valuable for designing in vivo cell tracking experiments. PROCEDURES: The ME's surface epitopes, contrast-producing paramagnetic magnetosomal iron, and genome were studied using immunocytochemistry (ICC), Fe and MRI contrast measurements, and quantitative polymerase chain reaction (qPCR), respectively...
June 19, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28616842/characterization-of-magneto-endosymbionts-as-mri-cell-labeling-and-tracking-agents
#6
Kimberly D Brewer, Ryan Spitler, Kayla R Lee, Andrea C Chan, Joyce C Barrozo, Abdul Wakeel, Chandler S Foote, Steven Machtaler, James Rioux, Juergen K Willmann, Papia Chakraborty, Bradley W Rice, Christopher H Contag, Caleb B Bell, Brian K Rutt
PURPOSE: Magneto-endosymbionts (MEs) show promise as living magnetic resonance imaging (MRI) contrast agents for in vivo cell tracking. Here we characterize the biomedical imaging properties of ME contrast agents, in vitro and in vivo. PROCEDURES: By adapting and engineering magnetotactic bacteria to the intracellular niche, we are creating magneto-endosymbionts (MEs) that offer advantages relative to passive iron-based contrast agents (superparamagnetic iron oxides, SPIOs) for cell tracking...
June 14, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28614512/sexual-and-reproductive-health-among-young-people-rio-de-janeiro-brazil
#7
Stella Regina Taquette, Denise Leite Maia Monteiro, Nádia Cristina Pinheiro Rodrigues, Riva Rozenberg, Daniela Contage Siccardi Menezes, Adriana de Oliveira Rodrigues, José Augusto Sapienza Ramos
We aimed to analyze the geographic distribution, the structure of healthcare services and the human resources of all units of the Sistema Único de Saúde (SUS - the Unified Health System) that provide sexual and reproductive health (SRH) services to the adolescent population in the second largest city in Brazil. We conducted a cross-sectional study with geographical mapping and data collection through a questionnaire applied in person with coordinators of the units or their representatives in 147 outpatient clinics in Rio de Janeiro that have SSR services...
June 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28591078/proximal-junctional-kyphosis-inter-and-intra-observer-reliability-of-radiographic-measurements-in-adult-spinal-deformity
#8
Farbod Rastegar, Alec Contag, Alan Daniels, Jayme Hiratzka, Clifford Lin, Jason Chang, Khoi Than, Ahmed Raslan, Christopher Kong, Ngoc-Lam Nguyen, Richard Hostin, Marie Kane, Robert Hart
STUDY DESIGN: Reliability study of radiographic measures of proximal junctional kyphosis in adult spinal deformity patients. OBJECTIVE: Assess impacts of level of proximal endpoint and vertebral fracture on reliability of measurement of junctional kyphosis. SUMMARY OF BACKGROUND DATA: Radiographic assessment is important in determining management of patients with Proximal Junctional Kyphosis (PJK) or Proximal Junctional Failure (PJF). No study to date has evaluated the reliability of radiographic measurement of the junctional kyphotic angle after surgery for Adult Spinal Deformity (ASD)...
June 6, 2017: Spine
https://www.readbyqxmd.com/read/28490473/specific-imaging-of-bacterial-infection-using-6%C3%A2-18-f-fluoromaltotriose-a-second-generation-pet-tracer-targeting-the-maltodextrin-transporter-in-bacteria
#9
Gayatri Gowrishankar, Jonathan Hardy, Mirwais Wardak, Mohammad Namavari, Robert E Reeves, Evgenios Neofytou, Ananth Srinivasan, Joseph C Wu, Christopher H Contag, Sanjiv Sam Gambhir
6″-(18)F-fluoromaltotriose is a PET tracer that can potentially be used to image and localize most bacterial infections, much like (18)F-FDG has been used to image and localize most cancers. However, unlike (18)F-FDG, 6″-(18)F-fluoromaltotriose is not taken up by inflammatory lesions and appears to be specific to bacterial infections by targeting the maltodextrin transporter that is expressed in gram-positive and gram-negative strains of bacteria. Methods: 6″-(18)F-fluoromaltotriose was synthesized with high radiochemical purity and evaluated in several clinically relevant bacterial strains in cultures and in living mice...
October 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28437855/mild-fetal-cerebral-ventriculomegaly-prevalence-characteristics-and-utility-of-ancillary-testing-in-cases-presenting-to-a-tertiary-referral-center
#10
Alison J Mehlhorn, Cara E Morin, Jade J Wong-You-Cheong, Stephen A Contag
OBJECTIVE: Ventriculomegaly is the most common fetal brain anomaly identified during prenatal anatomy ultrasound. The aim of our study was to characterize cases of mild ventriculomegaly and investigate the utility of ancillary tests. METHOD: We reviewed 121 cases of mild ventriculomegaly, defined as lateral ventricle diameter of 10 to 15 mm. Characteristics of the ventricular dilation as well as each pregnancy were investigated. Ancillary tests performed included follow-up magnetic resonance imaging (MRI), chromosomal abnormality testing, and maternal serologic infection screening...
July 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28428283/regulatory-aspects-of-optical-methods-and-exogenous-targets-for-cancer-detection
#11
Willemieke S Tummers, Jason M Warram, Kiranya E Tipirneni, John Fengler, Paula Jacobs, Lalitha Shankar, Lori Henderson, Betsy Ballard, Brian W Pogue, Jamey P Weichert, Michael Bouvet, Jonathan Sorger, Christopher H Contag, John V Frangioni, Michael F Tweedle, James P Basilion, Sanjiv S Gambhir, Eben L Rosenthal
Considerable advances in cancer-specific optical imaging have improved the precision of tumor resection. In comparison to traditional imaging modalities, this technology is unique in its ability to provide real-time feedback to the operating surgeon. Given the significant clinical implications of optical imaging, there is an urgent need to standardize surgical navigation tools and contrast agents to facilitate swift regulatory approval. Because fluorescence-enhanced surgery requires a combination of both device and drug, each may be developed in conjunction, or separately, which are important considerations in the approval process...
May 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28385925/neutrophil-myeloperoxidase-diminishes-the-toxic-effects-and-mortality-induced-by-lipopolysaccharide
#12
Laurent L Reber, Caitlin M Gillis, Philipp Starkl, Friederike Jönsson, Riccardo Sibilano, Thomas Marichal, Nicolas Gaudenzio, Marion Bérard, Stephan Rogalla, Christopher H Contag, Pierre Bruhns, Stephen J Galli
Neutrophils have crucial antimicrobial functions but are also thought to contribute to tissue injury upon exposure to bacterial products, such as lipopolysaccharide (LPS). To study the role of neutrophils in LPS-induced endotoxemia, we developed a new mouse model, PMN(DTR) mice, in which injection of diphtheria toxin induces selective neutrophil ablation. Using this model, we found, surprisingly, that neutrophils serve to protect the host from LPS-induced lethal inflammation. This protective role was observed in conventional and germ-free animal facilities, indicating that it does not depend on a particular microbiological environment...
May 1, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28358383/the-effect-of-maternal-age-on-fetal-and-neonatal-mortality
#13
S Chaudhary, S Contag
OBJECTIVE: Determine the gestational age at which the risk of fetal or neonatal death associated with delaying delivery by 1 week exceeds the risk of neonatal death associated with immediate delivery, stratified by maternal age intervals. STUDY DESIGN: We conducted a retrospective cohort study of live births, stillbirths and neonatal deaths that occurred in the United States between 2010 and 2013 using birth data. Women were classified into six age categories. Singleton, non-anomalous pregnancies without hypertensive disease or diabetes were included...
July 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28277366/association-of-maternal-obesity-with-maternal-and-neonatal-outcomes-in-cases-of-uterine-rupture
#14
Ruofan Yao, Katherine R Goetzinger, Sarah D Crimmins, Jerome N Kopelman, Stephen A Contag
OBJECTIVE: To describe the risk of adverse outcomes associated with uterine rupture in the setting of maternal obesity. METHODS: This was a retrospective cohort analysis of singleton nonanomalous neonates born after uterine rupture between 34 and 42 weeks of gestation. We derived data from the U.S. Natality Database from 2011 to 2014. Maternal prepregnancy body mass index (BMI) was categorized according to the World Health Organization classification. The rates of neonatal and maternal complications were calculated for each BMI class...
April 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28224324/targeted-nanomeetings-within-a-larger-delivery-congress
#15
EDITORIAL
Christopher H Contag
No abstract text is available yet for this article.
February 21, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28072479/reference-values-for-sonographically-estimated-fetal-weight-in-twin-gestations-stratified-by-chorionicity-a-single-center-study
#16
Rinat Gabbay-Benziv, Sarah Crimmins, Stephen A Contag
OBJECTIVES: To determine reference values for sonography-based estimated fetal weight (EFW) in twin gestations in one single tertiary medical center in the United States. METHODS: A retrospective longitudinal analysis of EFW evaluations of fetuses of twin gestations between November 2006 and June 2016. Fetuses with major congenital anomalies or chromosomal abnormalities were excluded. Estimated fetal weight was calculated using the Hadlock 1985 formula. Linear mixed models were used to allow for multiple but inconsistent observations among individuals, and to account for intertwin differences as well as for gender...
April 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28069945/charge-altering-releasable-transporters-carts-for-the-delivery-and-release-of-mrna-in-living-animals
#17
Colin J McKinlay, Jessica R Vargas, Timothy R Blake, Jonathan W Hardy, Masamitsu Kanada, Christopher H Contag, Paul A Wender, Robert M Waymouth
Functional delivery of mRNA to tissues in the body is key to implementing fundamentally new and potentially transformative strategies for vaccination, protein replacement therapy, and genome editing, collectively affecting approaches for the prevention, detection, and treatment of disease. Broadly applicable tools for the efficient delivery of mRNA into cultured cells would advance many areas of research, and effective and safe in vivo mRNA delivery could fundamentally transform clinical practice. Here we report the step-economical synthesis and evaluation of a tunable and effective class of synthetic biodegradable materials: charge-altering releasable transporters (CARTs) for mRNA delivery into cells...
January 24, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27748701/patient-satisfaction-after-adult-spinal-deformity-surgery-does-not-strongly-correlate-with-health-related-quality-of-life-scores-radiographic-parameters-or-occurrence-of-complications
#18
David Kojo Hamilton, Christopher Kong, Jayme Hiratzka, Alec G Contag, Tamir Ailon, Breton Line, Alan Daniels, Justin S Smith, Peter Passias, Themistocles Protopsaltis, Daniel Sciubba, Douglas Burton, Christopher Shaffrey, Eric Klineberg, Gregory Mundis, Han-Jo Kim, Virginie Lafage, Renaud Lafage, Justin Scheer, Oheneba Boachie-Adjei, Shay Bess, Robert A Hart
STUDY DESIGN: This is a multicenter retrospective review of prospectively collected cases. OBJECTIVE: Our objective was to evaluate the relationship between patient satisfaction, health-related quality of life (HRQoL) scores, complications, and radiographic measures at 2 years postoperative follow-up. SUMMARY OF BACKGROUND DATA: For patients receiving operative management for adult spine deformity (ASD), the relationship between HRQoL measures, radiographic parameters, postoperative complications, and self-reported satisfaction remains unclear...
May 15, 2017: Spine
https://www.readbyqxmd.com/read/27679430/selecting-caudal-fusion-levels-2%C3%A2-year-functional-and-stiffness-outcomes-with-matched-pairs-analysis-in-multilevel-fusion-to-l5-versus-s1
#19
Alan H Daniels, Heiko Koller, Shannon L Hiratzka, Michael Mayer, Oliver Meier, Alec Gabriel Contag, Adam E M Eltorai, Jayme Hiratzka, D Kojo Hamilton, Christopher I Shaffrey, Justin S Smith, Shay Bess, Eric O Klineberg, Christopher P Ames, Virginie Lafage, Breton Line, Frank J Schwab, Robert A Hart, International Spine Study Group
PURPOSE: Controversy persists as to whether to end multilevel thoracolumbar fusions caudally at L5 or S1. Some argue that stopping at L5 may preserve greater function, but there are few data comparing functional limitations due to lumbar stiffness in patients with fusion to L5 versus S1. The aim of this study was to evaluate whether patients undergoing multilevel thoracolumbar fusions with an L5 caudal endpoint have a better lumbosacral function than patients with an S1 caudal endpoint...
June 2017: European Spine Journal
https://www.readbyqxmd.com/read/27646137/ep16-07-influence-of-birthweight-on-prospective-stillbirth-risk-in-the-third-trimester
#20
S Contag, C Brown, S Crimmins, K R Goetzinger
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
keyword
keyword
103400
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"