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D Kojo Hamilton, Christopher Kong, Jayme Hiratzka, Alec G Contag, Tamir Ailon, Breton Line, Alan Daniels, Justin S Smith, Peter Passias, Themistocles Protopsaltis, Daniel Sciubba, Douglas Burton, Christopher Shaffrey, Eric Klineberg, Gregory Mundis, Han-Jo Kim, Virginie Lafage, Renaud Lafage, Justin Scheer, Oheneba Boachie-Adjei, Shay Bess, Robert Hart
STUDY DESIGN: This is a multicenter retrospective review of prospectively collected cases. OBJECTIVE: Our objective was to evaluate the relationship between patient satisfaction, HRQoL scores, complications, and radiographic measures at 2 years post-operative follow-up. SUMMARY OF BACKGROUND DATA: For patients receiving operative management for adult spine deformity (ASD), the relationship between health-related quality of life (HRQoL) measures, radiographic parameters, post-operative complications, and self-reported satisfaction remains unclear...
September 29, 2016: Spine
Alan H Daniels, Heiko Koller, Shannon L Hiratzka, Michael Mayer, Oliver Meier, Alec Gabriel Contag, Adam E M Eltorai, Jayme Hiratzka, D Kojo Hamilton, Christopher I Shaffrey, Justin S Smith, Shay Bess, Eric O Klineberg, Christopher P Ames, Virginie Lafage, Breton Line, Frank J Schwab, Robert A Hart, International Spine Study Group
PURPOSE: Controversy persists as to whether to end multilevel thoracolumbar fusions caudally at L5 or S1. Some argue that stopping at L5 may preserve greater function, but there are few data comparing functional limitations due to lumbar stiffness in patients with fusion to L5 versus S1. The aim of this study was to evaluate whether patients undergoing multilevel thoracolumbar fusions with an L5 caudal endpoint have a better lumbosacral function than patients with an S1 caudal endpoint...
September 27, 2016: European Spine Journal
S Contag, C Brown, S Crimmins, K R Goetzinger
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
Adam M Klein, Jennifer Gross
OBJECTIVES: To validate the use of a high-fidelity phonomicrosurgical trainer. STUDY DESIGN: A high-fidelity phonomicrosurgical trainer, based on a previously validated model by Contag et al.,(1) was designed with multilayered vocal folds that more closely mimic the consistency of true vocal folds, containing intracordal lesions to practice phonomicrosurgical removal. A training module was developed to simulate the true phonomicrosurgical experience. A validation study with novice and expert surgeons was conducted...
September 13, 2016: Laryngoscope
Stephen Contag, Clayton Brown, Jerome Kopelman, Katherine Goetzinger
OBJECTIVE: Immediate delivery compared with expectant management in a low risk population stratified by birthweight. METHODS: Retrospective cohort of births, stillbirths and neonatal deaths from 2010 through 2012 compiled by the National Center for Health Statistics. Birthweight categories were created using population derived deciles. Gestational age at birth was adjusted to account for time from death to delivery. The risk of immediate delivery was the neonatal death rate...
September 1, 2016: Journal of Maternal-fetal & Neonatal Medicine
Stephen Contag, Clayton Brown, Sarah Crimmins, Katherine Goetzinger
OBJECTIVE: The objective of this study was to determine the effect of birthweight on prospective stillbirth risk. METHODS: Cross-sectional study of singleton births in the United States from 2010 to 2012 from 32 through 42 weeks was conducted. Stillbirth risk was stratified by birthweight and gestational age adjusted for time from death to delivery. The primary outcome was the prospective stillbirth risk for each birthweight category. Student t-test was used for continuous data, chi-square to compare categorical data...
July 2016: American Journal of Perinatology Reports
Cara C Cockerill, Brian C Gross, Stephanie Contag, Sarah Rein, Eric J Moore, Kerry D Olsen, Laura J Orvidas
OBJECTIVE: To evaluate the presentation, treatments and outcomes in pediatric patients with salivary gland malignancies. STUDY DESIGN: Retrospective chart review (1950-2012), Prospective phone interview. METHODS: Patients ≤18 years old with a salivary gland malignancy treated at our institution were identified. Patients were also contacted by phone for a follow up survey. RESULTS: Fifty-six patients were identified...
September 2016: International Journal of Pediatric Otorhinolaryngology
Steven Sensarn, Cristina L Zavaleta, Ehud Segal, Stephan Rogalla, Wansik Lee, Sanjiv S Gambhir, Matthew Bogyo, Christopher H Contag
PURPOSE: Early and effective detection of cancers of the gastrointestinal tract will require novel molecular probes and advances in instrumentation that can reveal functional changes in dysplastic and malignant tissues. Here, we describe adaptation of a wide-field clinical fiberscope to perform wide-field fluorescence imaging while preserving its white-light capability for the purpose of providing wide-field fluorescence imaging capability to point-of-care microscopes. PROCEDURES: We developed and used a fluorescent fiberscope to detect signals from a quenched probe, BMV109, that becomes fluorescent when cleaved by, and covalently bound to, active cathepsin proteases...
May 6, 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Fabian Kiessling, Christopher H Contag
No abstract text is available yet for this article.
June 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Laura L Bronsart, Christopher H Contag
OBJECTIVE: The immune system, including the adaptive immune response, has recently been recognized as having a significant role in diet-induced insulin resistance. In this study, we aimed to determine if the adaptive immune system also functions in maintaining physiological glucose homeostasis in the absence of diet-induced disease. RESEARCH DESIGN AND METHODS: SCID mice and immunocompetent control animals were phenotypically assessed for variations in metabolic parameters and cytokine profiles...
2016: BMJ Open Diabetes Research & Care
Alan H Daniels, Satoshi Kawaguchi, Alec G Contag, Farbod Rastegar, Garrett Waagmeester, Paul A Anderson, Melanie Arthur, Robert A Hart
OBJECTIVE Beginning in 2008, the Centers for Medicare and Medicaid Service (CMS) determined that certain hospital-acquired adverse events such as surgical site infection (SSI) following spine surgery should never occur. The following year, they expanded the ruling to include deep vein thrombosis (DVT) and pulmonary embolism (PE) following total joint arthroplasty. Due to their ruling that "never events" are not the payers' responsibility, CMS insists that the costs of managing these complications be borne by hospitals and health care providers, rather than billings to health care payers for additional care required in their management...
August 2016: Journal of Neurosurgery. Spine
Jianghong Rao, Christopher H Contag
No abstract text is available yet for this article.
February 17, 2016: Bioconjugate Chemistry
Laura Bronsart, Linh Nguyen, Aida Habtezion, Christopher Contag
PURPOSE: Reactive oxygen species (ROS) are important contributors to inflammatory bowel disease (IBD); however, there are insufficient tools for their in vivo evaluation. PROCEDURES: To determine if a chemiluminescent ROS reporter, coelenterazine, would be a useful tool for the detection of immune cell activation, the macrophage cell line (RAW 264.7) was treated with phorbol myristate acetate (PMA). Additionally, coelenterazine was used to monitor the changes in ROS production over time in a mouse model of IBD...
August 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Laura L Bronsart, Christian Stokes, Christopher H Contag
Superoxide anion is produced during normal cellular respiration and plays key roles in cellular physiology with its dysregulation being associated with a variety of diseases. Superoxide anion is a short-lived molecule and, therefore, its homeostatic regulation and role in biology and disease requires dynamic quantification with fine temporal resolution. Here we validated coelenterazine as a reporter of intracellular superoxide anion concentration and used it as a dynamic measure both in vitro and in vivo. Chemiluminescence was dependent upon superoxide anion levels, including those produced during cellular respiration, and concentrations varied both kinetically and temporally in response to physiologically relevant fluctuations in glucose levels...
2016: PloS One
Zach S Templeton, Wen-Rong Lie, Weiqi Wang, Yael Rosenberg-Hasson, Rajiv V Alluri, John S Tamaresis, Michael H Bachmann, Kitty Lee, William J Maloney, Christopher H Contag, Bonnie L King
BACKGROUND/OBJECTIVES: Bone is a preferred site of breast cancer metastasis, suggesting the presence of tissue-specific features that attract and promote the outgrowth of breast cancer cells. We sought to identify parameters of human bone tissue associated with breast cancer cell osteotropism and colonization in the metastatic niche. METHODS: Migration and colonization patterns of MDA-MB-231-fLuc-EGFP (luciferase-enhanced green fluorescence protein) and MCF-7-fLuc-EGFP breast cancer cells were studied in co-culture with cancellous bone tissue fragments isolated from 14 hip arthroplasties...
December 2015: Neoplasia: An International Journal for Oncology Research
Jayme Hiratzka, Farbod Rastegar, Alec G Contag, Daniel C Norvell, Paul A Anderson, Robert A Hart
Study Design Systematic review. Objectives (1) To compare the quality of adverse event (AE) methodology and reporting among randomized trials comparing lumbar fusion with lumbar total disk replacement (TDR) using established AE reporting systems; (2) to compare the AEs and reoperations of lumbar spinal fusion with those from lumbar TDR; (3) to make recommendations on how to report AEs in randomized controlled trials (RCTs) so that surgeons and patients have more-detailed and comprehensive information when making treatment decisions...
December 2015: Global Spine Journal
Jiansheng Wu, Wudan Xie, Weifeng Li, Jiacheng Li
PM2.5 refers to particulate matter (PM) in air that is less than 2.5 μm in aerodynamic diameter, which has negative effects on air quality and human health. PM2.5 is the main pollutant source in haze occurring in Beijing, and it also has caused many problems in other cities. Previous studies have focused mostly on the relationship between land use and air quality, but less research has specifically explored the effects of urban landscape patterns on PM2.5. This study considered the rapidly growing and heavily polluted Beijing, China...
2015: PloS One
Roger L Kaspar, Robyn P Hickerson, Emilio González-González, Manuel A Flores, Tycho P Speaker, Faye A Rogers, Leonard M Milstone, Christopher H Contag
Monogenic skin diseases arise from well-defined single gene mutations, and in some cases a single point mutation. As the target cells are superficial, these diseases are ideally suited for treatment by nucleic acid-based therapies as well as monitoring through a variety of noninvasive imaging technologies. Despite the accessibility of the skin, there remain formidable barriers for functional delivery of nucleic acids to the target cells within the dermis and epidermis. These barriers include the stratum corneum and the layered structure of the skin, as well as more locally, the cellular, endosomal and nuclear membranes...
2016: Methods in Molecular Biology
Stephen A Contag, Jesse Woo, David B Schwartz, Pedro P Arrabal, Geralyn O'Reilly, Margaret Harper
OBJECTIVE: To determine whether a reinforcing cerclage (RC) for a short cervix measured after the primary cerclage procedure prolonged pregnancy. METHODS: We conducted a retrospective cohort study of 157 women with singleton gestations who underwent cerclage for standard indications. Women were grouped according to cervical length (CL) at the time of follow-up 1-2 weeks after the initial cerclage placement: ≥25 mm (106 women) and <25 mm with (20 women) or without RC (31 women)...
2016: Journal of Maternal-fetal & Neonatal Medicine
Laura L Bronsart, Christian Stokes, Christopher H Contag
PURPOSE: We evaluated the small molecule coelenterazine as a potential reporter of cancer-associated superoxide anion in cell culture and in mice. PROCEDURES: The superoxide anion concentrations of various cancer cell lines were quantified by coelenterazine chemiluminescence in vitro. Coelenteramide fluorescence was detected via flow cytometry and fluorescent microscopy. Coelenterazine was used for the in vivo detection of cancer-associated superoxide anion using the 4T1 breast adenocarcinoma mouse model...
April 2016: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
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