Emily S Barrett, Alexandra Sullivan, Tomomi Workman, Yuhong Zhang, Christine T Loftus, Adam A Szpiro, Alison Paquette, James W MacDonald, Michael Coccia, Roger Smith, Maria Bowman, Alicia Smith, Karen Derefinko, Ruby H N Nguyen, Qi Zhao, Sheela Sathyanarayana, Catherine Karr, Kaja Z LeWinn, Nicole R Bush
Placental corticotropin-releasing hormone (pCRH) is a neuroactive peptide produced in high concentrations in mid-late pregnancy, during key periods of fetal brain development. Some evidence suggests that higher pCRH exposure during gestation is associated with adverse neurodevelopment, particularly in female offspring. In 858 mother-child dyads from the sociodemographically diverse CANDLE cohort (Memphis, TN), we examined: (1) the slope of pCRH rise in mid-late pregnancy and (2) estimated pCRH at delivery as a measure of cumulative prenatal exposure...
February 16, 2024: Psychoneuroendocrinology