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https://www.readbyqxmd.com/read/29232047/antibiotic-prophylaxis-in-ureteroscopic-lithotripsy-a%C3%A2-systematic-review-and-meta-analysis-of-comparative-studies
#1
Tuo Deng, Bing Liu, Xiaolu Duan, Chao Cai, Zhijian Zhao, Wei Zhu, Junhong Fan, Wenqi Wu, Guohua Zeng
OBJECTIVE: To explore the efficacy and detailed strategies of antibiotic prophylaxis in ureteroscopic lithotripsy (URL) through a systematic review and meta-analysis. MATERIALS AND METHODS: A systematic literature search using Pubmed, Embase, Medline, Cochrane Library, CBM, CNKI and VIP databases was performed to obtain comparative studies on the efficacy of different antibiotic prophylaxis strategies in URL for preventing postoperative infections. The last search was conducted on June 25, 2017...
December 12, 2017: BJU International
https://www.readbyqxmd.com/read/29230940/the-effects-of-recreational-ketamine-cystitis-on-urinary-tract-reconstruction-a-surgical-challenge
#2
Néha Sihra, Jeremy Ockrim, Dan Wood
OBJECTIVES: To identify the rate of post-operative complications in patients who require surgical reconstruction for ketamine-induced urinary tract dysfunction and to identify any predictors for poor post-operative outcome with subsequent management strategies. MATERIALS AND METHODS: A retrospective review of data collected between 2007 and 2017 was performed. Evaluation included CT urogram, cystoscopy and biopsy. Indications and outcomes for surgical intervention were assessed...
December 12, 2017: BJU International
https://www.readbyqxmd.com/read/29230684/imipenem-relebactam-and-meropenem-vaborbactam-two-novel-carbapenem-%C3%AE-lactamase-inhibitor-combinations
#3
REVIEW
George G Zhanel, Courtney K Lawrence, Heather Adam, Frank Schweizer, Sheryl Zelenitsky, Michael Zhanel, Philippe R S Lagacé-Wiens, Andrew Walkty, Andrew Denisuik, Alyssa Golden, Alfred S Gin, Daryl J Hoban, Joseph P Lynch, James A Karlowsky
Relebactam (formerly known as MK-7655) is a non-β-lactam, bicyclic diazabicyclooctane, β-lactamase inhibitor that is structurally related to avibactam, differing by the addition of a piperidine ring to the 2-position carbonyl group. Vaborbactam (formerly known as RPX7009) is a non-β-lactam, cyclic, boronic acid-based, β-lactamase inhibitor. The structure of vaborbactam is unlike any other currently marketed β-lactamase inhibitor. Both inhibitors display activity against Ambler class A [including extended-spectrum β-lactamases (ESBLs), Klebsiella pneumoniae carbapenemases (KPCs)] and class C β-lactamases (AmpC)...
December 12, 2017: Drugs
https://www.readbyqxmd.com/read/29230385/urinary-microbiome-and-psychological-factors-in-women-with-overactive-bladder
#4
Peng Wu, Yang Chen, Jie Zhao, Guihao Zhang, Jiawei Chen, Junpeng Wang, Huijian Zhang
Objectives: Emerging evidence indicates that alterations to the urinary microbiome are related to lower urinary tract symptoms. Overactive bladder (OAB) is a common disorder with complex etiologies and usually accompanied by psychological diseases. More information concerning the urinary microbiome and psychological factors in OAB is required. The aim of this study was to characterize the female urinary microbiome associated with OAB and investigate the relationships between urinary microbiome and psychological factors...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29230259/-nosocomial-urinary-tract-and-surgical-site-infection-rates-in-the-maternity-ward-at-the-general-referral-hospital-in-katuba-lubumbashi-democratic-republic-of-the-congo
#5
Hendrick Mbutshu Lukuke, Eric Kasamba, Abdulu Mahuridi, Roger Ngatu Nlandu, Suganuma Narufumi, Abel Ntambue Mukengeshayi, Vicky Malou, Michel Makoutode, Françoise Malonga Kaj
Introduction: In Intertropical Africa hospitalized patients are exposed to a risk of nosocomial infections. The dearth of published data on this subject limits the descriptive analysis of the situation. This study aimed to determine the incidence, the germs responsible for these infections and the risk factors of nosocomial infections in the Maternity Ward at the General Referral Hospital in Katuba, Lubumbashi, Democratic Republic of the Congo. Methods: We conducted a descriptive, longitudinal study from 1 October 2014 to 1 January 2015...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29229730/role-of-ethanolamine-utilization-genes-in-host-colonization-during-urinary-tract-infection
#6
Anna Sintsova, Sara Smith, Sargurunathan Subashchandrabose, Harry L Mobley
Urinary tract infection (UTI) is the second most common infection in humans, making it a global health priority. Nearly half of all women will experience a symptomatic UTI, with uropathogenic E. coli (UPEC) being the major causative agent of the infection. While there has been extensive research on UPEC virulence determinants, the importance of host-specific metabolism remains understudied. Here we report that UPEC upregulate the expression of ethanolamine utilization genes during uncomplicated UTIs in humans...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29229509/diagnosis-of-congenital-abnormalities-with-post-mortem-ultrasound-in-perinatal-death
#7
L Tuchtan, E Lesieur, C Bartoli, C Delteil, L Sarda-Quarello, J Torrents, S Sigaudy, M-D Piercecchi, G Gorincour
PURPOSE: To determine the sensitivity and specificity of post-mortem ultrasound in the diagnosis of major congenital abnormalities of fetuses using conventional autopsy as the standard of reference. MATERIAL AND METHODS: All fetuses coming from terminations of pregnancy or intrauterine fetal deaths in a single institution were included. A total of 75 fetuses were included during the study period. The results of post-mortem ultrasound examinations were compared to those of conventional autopsy that served as standard of reference...
December 8, 2017: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/29229166/holding-water-congenital-anomalies-of-the-kidney-and-urinary-tract-ckd-and-the-ongoing-role-of-excellence-in-plumbing
#8
REVIEW
Lars J Cisek
Congenital anomalies of the kidneys and urinary tracts can result in diminished natal kidney function, possibly through common embryologic pathway disruption or as a result of development taking place in the face of disordered 'post-renal' drainage. Impaired conduit and reservoir function present potential for an ongoing assault leading to further deterioration and progression of chronic kidney disease, a risk that extends to adults with these conditions, even after "correction". The drainage and storage aspects of the urinary system that can impact kidney function are reviewed with attention to correctable or manageable problems including: Bladder dysfunction wherein the low pressure storage of urine is compromised requiring the kidney to work against a pressure gradient, the classic post renal failure problem...
November 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29229123/sarcopenia-is-a-risk-factor-for-complications-and-an-independent-predictor-of-hospital-length-of-stay-in-trauma-patients
#9
James DeAndrade, Mark Pedersen, Luis Garcia, Peter Nau
BACKGROUND: Sarcopenia is an independent risk factor for adverse outcomes in critically ill patients. The impact of sarcopenia on morbidity and length of stay in a trauma population has not been completely defined. This project evaluated the influence of sarcopenia on patients admitted to the trauma service. MATERIALS AND METHODS: A retrospective review of 778 patients presenting as a trauma alert at a single institution from 2012-2014 was completed. Records were abstracted for comorbidities and hospital complications...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29229015/risk-factors-for-acquisition-of-multidrug-resistant-escherichia-coli-and-development-of-community-acquired-urinary-tract-infections
#10
U V Ukah, M Glass, B Avery, D Daignault, M R Mulvey, R J Reid-Smith, E J Parmley, A Portt, P Boerlin, A R Manges
We examined risk factors associated with the intestinal acquisition of antimicrobial-resistant extraintestinal pathogenic Escherichia coli (ExPEC) and development of community-acquired urinary tract infection (UTI) in a case-control study of young women across Canada. A total of 399 women were recruited; 164 women had a UTI caused by E. coli resistant to ⩾1 antimicrobial classes and 98 had a UTI caused by E. coli resistant to ⩾3 antimicrobial classes. After adjustment for age, student health service (region of Canada) and either prior antibiotic use or UTI history, consumption of processed or ground chicken, cooked or raw shellfish, street foods and any organic fruit; as well as, contact with chickens, dogs and pet treats; and travel to Asia, were associated with an increased risk of UTI caused by antimicrobial resistant E...
December 12, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29228985/investigating-the-burden-of-antibiotic-resistance-in-ethnic-minority-groups-in-high-income-countries-protocol-for-a-systematic-review-and-meta-analysis
#11
Hannah Lishman, Paul Aylin, Vivian Alividza, Enrique Castro-Sanchez, Anuja Chatterjee, Victor Mariano, Alan P Johnson, Samir Jeraj, Céire Costelloe
BACKGROUND: Antibiotic resistance (ABR) is an urgent problem globally, with overuse and misuse of antibiotics being one of the main drivers of antibiotic-resistant infections. There is increasing evidence that the burden of community-acquired infections such as urinary tract infections and bloodstream infections (both susceptible and resistant) may differ by ethnicity, although the reasons behind this relationship are not well defined. It has been demonstrated that socioeconomic status and ethnicity are often highly correlated with each other; however, it is not yet known whether accounting for deprivation completely explains any discrepancy seen in infection risk...
December 11, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29228960/cross-sectional-survey-on-the-use-and-impact-of-the-danish-national-antibiotic-use-guidelines-for-companion-animal-practice
#12
Lisbeth Rem Jessen, Tina Møller Sørensen, Zenia Littau Lilja, Maja Kristensen, Tine Hald, Peter Damborg
BACKGROUND: The Danish antibiotic use guidelines for companion animal practice were published by the Danish Veterinary Association in 2012. Since then, national surveillance data indicate a 10% reduction in the total use of antibiotics for companion animals, particularly a marked reduction in the use of third generation cephalosporins. The aim of the study was to assess if and how the guidelines have impacted diagnostic and antibiotic prescription habits of the users, and to identify user perceived barriers to implementation...
December 11, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29227744/molecular-epidemiology-of-klebsiella-pneumoniae-strains-causing-bloodstream-infections-in-adults
#13
Meritxell Cubero, Imma Grau, Fe Tubau, Román Pallarés, M Ángeles Domínguez, Josefina Liñares, Carmen Ardanuy
Molecular epidemiology of Klebsiella pneumoniae bacteremic strains allows for a better understanding of preventive and therapeutic strategies. Clinical and microbiological characteristics of 348 K. pneumoniae bacteremia cases (2007-2009) were retrospectively characterized by multilocus sequence typing and extended-spectrum beta-lactamases (ESBL) production. Overall, 223 (64.08%) cases were nosocomial (NA), 58 (16.67%) healthcare associated, and 67 (19.25%) community acquired. The main infection origins were urinary tract (16...
December 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29227741/new-subclass-b1-metallo-%C3%AE-lactamase-gene-from-a-clinical-pathogenic-myroides-odoratus-strain
#14
Su Xu, Yijian Chen, Zhuyingjie Fu, Ying Li, Guixiu Shi, Xiaogang Xu, Yang Liu, Minggui Wang
Myroides odoratus is a low-virulence opportunistic human pathogen. Infections caused by M. odoratus are not common, but reports are increasing in recent years. The biggest challenge for treatment is its resistance to most antibiotics. In 2015, we isolated a pathogenic multidrug-resistant strain of M. odoratus from a urinary tract infection (UTI) patient's urine sample. To report the experience in managing M. odoratus-related UTI and investigate the genetic mechanism of this carbapenem-resistant strain, we conducted a series of microbiological and molecular studies...
December 11, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29227142/perineal-urethrostomy-to-treat-obstructive-urolithiasis-in-a-captive-hand-raised-steenbok-i-raphicerus-campestris-i
#15
Luke A Poore, Ross Hendry, Johan Steyl, Silke Pfitzer
The steenbok (Raphicerus campestris) is a small antelope of the family Bovidae native to the African continent. Urolithiasis, the formation of urinary calculi in the urinary tract, can be caused by a variety of factors such as diet, dehydration, infection and anatomical predisposition. Urolithiasis, with uroliths identified as magnesium calcium phosphate carbonate in composition, was diagnosed in a hand-reared 5-month-old steenbok. Perineal urethrostomy was performed as a component of the broad treatment regime that included fluid therapy, antibiotic and anti-inflammatory treatment...
December 8, 2017: Journal of the South African Veterinary Association
https://www.readbyqxmd.com/read/29226922/a-polymyxin-b-silver-nanoparticle-colloidal-system-and-the-application-of-lipopolysaccharide-analysis
#16
Tao Liu, Liqian Gao, Jing Zhao, Ya Cao, Yuguo Tang, Peng Miao
Polymyxin B (PMB) is a small cyclic polycationic lipopeptide, which can be used as an antibiotic drug against Gram-negative bacteria. In this work, the interaction between citrate capped silver nanoparticles (AgNPs) and PMB is studied. Experimental results show that the association constant is extremely high and the binding event leads to a significant variation in the localized surface plasmon resonance (LSPR) of AgNPs. Moreover, the PMB-AgNP colloidal system can be further exploited as a sensitive analytical platform...
December 11, 2017: Analyst
https://www.readbyqxmd.com/read/29226740/do-infants-in-the-neonatal-intensive-care-unit-diagnosed-with-urinary-tract-infection-need-a-routine-voiding-cystourethrogram
#17
Dustin D Flannery, Erik Brandsma, Judy Saslow, Amy B Mackley, David A Paul, Zubair H Aghai
OBJECTIVE: To determine if infants diagnosed with urinary tract infection (UTI) in the neonatal intensive care unit (NICU) require a routine voiding cystourethrogram (VCUG). STUDY DESIGN: Retrospective data analysis from three centers for infants admitted to the NICU born between 2000 and 2013 and diagnosed with UTI. RESULTS: One hundred twenty-six infants from three centers were diagnosed with UTI during their hospitalization. Renal ultrasound (RUS) was performed in 115 infants (91...
December 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29226304/successful-medical-management-of-pseudomembranous-cystitis-in-three-cats-with-lower-urinary-tract-obstruction
#18
A Vila, R Movilla, J Castro, C Mallol, R Novellas, Y Espada, X Roura
CASE REPORT: The present case series describes the clinical course and outcome of three cats diagnosed with pseudomembranous cystitis. This is an uncommon presentation of lower urinary tract obstruction but can be easily be identified by ultrasonography, revealing severe bladder wall thickening and thin hyperechoic luminal strips. The condition can be secondary to severe bacterial urinary tract infection. All cats were successfully treated with medical management only, mainly based on antimicrobials and individualised supportive therapy...
December 10, 2017: Australian Veterinary Journal
https://www.readbyqxmd.com/read/29226171/antimicrobial-resistance-of-sterile-site-infections-in-sub-saharan-africa-a-systematic-review
#19
Meklit Workneh, Morgan J Katz, Mohammed Lamorde, Sara E Cosgrove, Yukari C Manabe
Sparse data exist from sub-Saharan Africa (SSA) on the prevalence of antimicrobial resistance (AMR). A prior review of antimicrobial resistance in SSA from 1990 to 2013 showed a high prevalence of AMR to commonly used antibiotics in this setting. We reviewed the literature published since 2013. Four databases (PubMed, EMBASE, Cochrane, and African Journals Online) were searched for articles between February 2013 and March 2016 with a focus on sterile site infections (bacteremia, urinary tract infections [UTIs], and meningitis)...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29226170/inappropriate-management-of-asymptomatic-patients-with-positive-urine-cultures-a-systematic-review-and-meta-analysis
#20
Myrto Eleni Flokas, Nikolaos Andreatos, Michail Alevizakos, Alireza Kalbasi, Pelin Onur, Eleftherios Mylonakis
Background: Mismanagement of asymptomatic patients with positive urine cultures (referred to as asymptomatic bacteriuria [ASB] in the literature) promotes antimicrobial resistance and results in unnecessary antimicrobial-related adverse events and increased health care costs. Methods: We conducted a systematic review and meta-analysis of studies that reported on the rate of inappropriate ASB treatment published from 2004 to August 2016. The appropriateness of antimicrobial administration was based on guidelines published by the Infectious Diseases Society of America...
2017: Open Forum Infectious Diseases
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