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B Brüggenjürgen, T Baker, R Bhogal, F Ahmed
BACKGROUND: Chronic migraine (CM) is a neurological disorder associated with substantial disability. Botulinum toxin type A (Botox) is an approved and effective preventive treatment option for adult patients with CM. Transcranial magnetic stimulation (TMS) is an alternative treatment device delivering a brief pre-set magnetic pulse used for self-administration by the patient at home. Despite being available in a risk share scheme TMS is perceived to be more costly in the UK. The objective of this study was to analyse the incremental costs of TMS compared to Botox in refractory CM patients both for a UK individual funding request setting as well as for an average UK specialist center setting...
2016: SpringerPlus
Jenny Montgomery, Sarah McCusker, Kerry Lang, Susan Grosse, Alastair Mace, Ruby Lumley, Haytham Kubba
OBJECTIVES: Sialorrhoea (drooling) is defined as the involuntary escape of saliva from the mouth. It is considered normal in young children but may cause social problems in older children. Sialorrhoea is frequently seen in children with cerebral palsy, with rates between 10% and 58% and in other neurodevelopmental diseases. Management of these children can be challenging and often requires an individual and stepwise approach. This is a large case series of children managed at the saliva control clinic in Glasgow, Scotland...
June 2016: International Journal of Pediatric Otorhinolaryngology
Shaun C Desai, Andrea M Park, Rebecca D Chernock, Randal C Paniello
OBJECTIVES/HYPOTHESIS: A simple, safe and effective surgical alternative for treating adductor spasmodic dysphonia (ADSD) would appeal to many patients. This study evaluates a new option, using radiofrequency-induced thermotherapy (RFITT) of the thyroarytenoid muscle (TA) via the minithyrotomy approach to reduce the force of adduction. METHODS: Fifteen dogs were used. In part 1, the optimal RFITT power settings, exposure time, probe location, and number of passes were determined...
October 2016: Laryngoscope
Necole M Streeper, Stephen Y Nakada, Margaret L Wertheim, Sara L Best
PURPOSE: We evaluated the use of periureteral injection of botulinum toxin type A (Botox(®), BTX-A) to facilitate passage of ureteral stones in a porcine model. We believe that reducing detrusor muscle tone around the intramural ureter may facilitate passage of ureteral stones through the ureterovesical junction. MATERIALS AND METHODS: With complete Institutional Animal Care and Use Committee approval, artificial stones (BegoStone plus) were placed by retrograde ureteroscopy into the proximal ureter using fluoroscopic guidance using an in-vivo porcine model...
March 2016: Journal of Endourology
Nick Freemantle, Kristin Khalaf, Clara Loveman, Sanja Stanisic, Dmitry Gultyaev, Johanna Lister, Marcus Drake
The cost-effectiveness of onabotulinumtoxinA (BOTOX(®)) 100 U + best supportive care (BSC) was compared with BSC alone in the management of idiopathic overactive bladder in adult patients who are not adequately managed with anticholinergics. BSC included incontinence pads and, for a proportion of patients, anticholinergics and/or occasional clean intermittent catheterisation. A five-state Markov model was used to estimate total costs and outcomes over a 10-year period. The cohort was based on data from two placebo-controlled trials and a long-term extension study of onabotulinumtoxinA...
September 2016: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
Kevin L Grimes, Haruhiro Inoue, Manabu Onimaru, Haruo Ikeda, Amarit Tansawet, Robert Bechara, Shinwa Tanaka
BACKGROUND: Since its introduction in 2010, per oral endoscopic myotomy (POEM) has offered an alternative to laparoscopic Heller myotomy for the treatment of achalasia. A gastric myotomy length of 3 cm has been recommended; however, it can be difficult to ensure that adequate submucosal dissection has been performed during the procedure. Commonly accepted endoscopic markers of the gastric side can be inaccurate, particularly in patients with prior endoscopic treatments, such as balloon dilation or Botox injection of the lower esophageal sphincter...
April 2016: Surgical Endoscopy
Edward L Jones, Michael P Meara, Matthew R Pittman, Jeffrey W Hazey, Kyle A Perry
INTRODUCTION: Per-oral endoscopic myotomy (POEM) is an emerging treatment for achalasia. Pneumatic dilation, botulinum toxin injection, and previous myotomy increase the difficulty of subsequent Heller myotomy, but their impact on POEM remains unknown. The purpose of this study was to compare patients who had undergone prior treatment for their achalasia to those undergoing POEM as an initial therapy. METHODS AND PROCEDURES: All patients undergoing POEM were entered into a prospective database from August 2012 to October 2014...
April 2016: Surgical Endoscopy
Samuel C Lien, Yaxi Hu, Adi Wollstein, Michael G Franz, Shaun P Patel, William M Kuzon, Melanie G Urbanchek
BACKGROUND: Incisional hernias are a complication in 10% of all open abdominal operations and can result in substantial morbidity. The purpose of this study was to determine whether inhibiting abdominal muscle contraction influences incisional hernia formation during the fascial healing after laparotomy. We hypothesized that decreasing the deformation of the abdominal musculature would decrease the size or occurrence of an incisional hernia. METHODS: Using an established rat model for incisional hernia, a laparotomy through the linea alba was closed with 1 mid-incision, fast-absorbing suture...
July 2015: Surgery
Mohit Gilotra, Thao Nguyen, Matthew Christian, Derik Davis, R Frank Henn, Syed Ashfaq Hasan
Re-tear continues to be a problem after rotator cuff repair. Intramuscular botulinum toxin (Botox) injection can help optimize tension at the repair site to promote healing but could have an adverse effect on the degenerated muscle in a chronic tear. We hypothesized that Botox injection would improve repair characteristics without adverse effect on the muscle in a chronic rotator cuff tear model. The supraspinatus tendon of both shoulders in 14 rabbits underwent delayed repair 12 weeks after transection. One shoulder was treated with intramuscular Botox injection and the other with a saline control injection...
August 2015: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Neal D Goldman, Leighanne H Dorton, Kristin K Marcum, Ryan M Gilbert, Laura F Sandoval
Chronic headaches are common and can have a significant effect on quality of life. Approved treatment options are vast and include the use botulinum toxin injections. The objective of this study is to evaluate the effects of purely cosmetic onabotulinumtoxinA (BOTOX) injections on the frequency and severity of chronic headaches. Patients seeking treatment of hyperfunctional facial lines were enrolled to complete pre- and posttreatment questionnaires assessing headache symptoms. Quantitative data was compared using paired two-tailed student t-tests between groups of patients who received onabotulinumtoxinA injections, both onabotulinumtoxinA and hyaluronic acid (Restylane) injections, and hyaluronic acid injections...
September 2014: Journal of Cosmetic Dermatology
F de Andrés-Nogales, A Morell, J Aracil, C Torres, I Oyagüez, M A Casado
OBJECTIVE: To estimate treatment costs of blepharospasm, cervical dystonia(CD), upper limb spasticity (ULS) and spasticity in children with cerebral palsy (SCCP) with botulinum neurotoxin type A (BoNT-A) in Spain. METHOD: Annual BoNT-A treatment costs were calculated (2013 ex-factory price () applying RDL 8/2010 and RDL 9/2011 deductions), based on initial dose (id), average dose (ad) and maximum dose (md) according to Summary of Product Characteristics of Botox® (100U/50U), Dysport®(500U) and Xeomin® (100U) and considering the use of complete vials...
May 2014: Farmacia Hospitalaria
M K Bernhard, A Bertsche, S Syrbe, S Weise, A Merkenschlager
BACKGROUND: The prevalence of chronic headaches in children and adolescents is up to 2 % resulting in the beginning of the later typical headache careers of adults. The therapy for chronic migraine with botulinum toxin is now established in adults. However, there is only limited experience in the use of botulinum toxin in paediatric patients. METHODS: 10 patients aged 13 - 17 years who suffered from chronic migraine according to the IHS criteria were injected at 31 specific injection points of the head and neck muscles with a total amount of 150 IE of botulinum toxin A (Botox®) according to the approved scheme...
January 2014: Fortschritte der Neurologie-Psychiatrie
R A C Chate
Until recently, cosmetic dentistry has focused on the use of traditional restorative techniques, bleaching and the so-called facial rejuvenators such as injectable dermal fillers and Botox. More latterly, the short-term use of aesthetic removable aligners and ceramic fixed appliance brackets have been promoted for use by general dental practitioners as a means of minimising the invasive amount of restorative dental treatment that would otherwise be required to achieve the desired degree of aesthetic improvement...
December 2013: British Dental Journal
Jacob Gady, Elie M Ferneini
PURPOSE: To determine whether botulinum toxin type A (BOTOX ) is effective for the prophylactic treatment of headaches in adults. MATERIALS AND METHODS: A retrospective literature reviewwas performed. The outcome of various studies is discussed, including whether a decrease in the intensity as well as the occurrence of tension and migraine headaches was accomplished. RESULTS: The approval for botulinum toxin A for the treatment of migraine was based largely on the results of Allergan's PREEMPT Phase III trial...
March 2013: Connecticut Medicine
Shira Sheen-Ophir, Yehosua Almog
BotuLinum toxin A (Botox, Allegan) is a potent neurotoxin that blocks the release of acetylcholine at the neuromuscular junction of cholinergic nerves. Botulinum toxin was introduced to clinical medicine in 1980. Since then it has become a major therapeutic drug in many medical sub-specialties and its use for facial rejuvenation has become increasingly popular. Diplopia after botulinum toxin injection for facial rejuvenation is a rare and transient complication which is related to chemodenervation of adjacent muscle groups...
February 2013: Harefuah
M Brown, G Nicholson, M C Ardila, A Satorius, R S Broide, K Clarke, T Hunt, J Francis
IncobotulinumtoxinA (Xeomin®) and onabotulinumtoxinA (BOTOX®) are unique botulinum neurotoxin type A (BoNT/A)-derived drugs. IncobotulinumtoxinA utilizes the naked 150 kDa holotoxin portion of BoNT/A, whereas onabotulinumtoxinA uses the complete native 900 kDa complex as drug substance. On the basis of purportedly similar pharmacological characteristics, these formulations were evaluated for potency by LD₅₀ and mouse Digit Abduction Score (DAS) bioassays. DAS was also used to assess antigenicity. Full-range DAS dose-response profiles were achieved with four lots of each product, with similar observations between lots for a given product...
February 2013: Journal of Neural Transmission
Abie H Mendelsohn, Gerald S Berke
OBJECTIVES: Currently, botulinum toxin (Botox) injection is the standard of treatment for adductor spasmodic dysphonia (ADSD). We sought to compare the outcome of selective laryngeal adductor denervation-reinnervation (SLAD-R) surgery for ADSD to that of Botox injections. METHODS: Patient-oriented measures (VHI-10) and objective single-blinded gradings of digital voice recordings were utilized as outcome measures. The surgical cohort, recruited by retrospective patient selection, consisted of 77 patients with a mean follow-up time of 7...
April 2012: Annals of Otology, Rhinology, and Laryngology
Kim D Blake, Jillian MacCuspie, Gerard Corsten
CHARGE syndrome is a genetic disorder caused by a mutation in the CHD7 gene on chromosome 8. Major clinical diagnostic criteria for this heterogeneous disorder include ocular coloboma, choanal atresia/stenosis, characteristic external and internal ear abnormalities, and cranial nerve abnormalities. Patients with CHARGE syndrome often have dysphagia and are at high risk for aspiration of both upper and lower gastrointestinal secretions. The following case-report describes the use of Botulinum toxin A (Botox) to reduce excess salivary secretions in a ventilator dependant infant who would have required a tracheotomy...
April 2012: American Journal of Medical Genetics. Part A
T Andersson, P Eliasson, P Aspenberg
Growth Hormone stimulates bone growth and fracture repair. It acts mainly by increasing the systemic levels of IGF-1. Local treatment with IGF-1 appears to stimulate tendon healing. We therefore hypothesized that systemic treatment with Growth Hormone would also stimulate tendon healing. Rat Achilles tendons were transected and left to heal. 4 groups were studied. Intramuscular injections of botulinum toxin A (Botox) were used to reduce loading in 2 groups. The animals were randomized to twice daily injections of Growth Hormone (n=2×10) or saline (n=2×10), and killed after 10 days...
March 2012: International Journal of Sports Medicine
Marielle Kabbouche, Hope O'Brien, Andrew D Hershey
Chronic migraine occurs in about 3% of pediatric headaches. Many would be intractable to more than two preventive medications. OnabotulinumtoxinA has been approved by the US Food and Drug Administration for the use of chronic migraine in adults in 2010. Data on effectiveness and tolerability in the pediatric population are very limited. The study described in this article is a retrospective review of available data of all patients who received OnabotulinumtoxinA for chronic migraine in a large pediatric headache center from 2004 to 2010...
April 2012: Current Neurology and Neuroscience Reports
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