keyword
MENU ▼
Read by QxMD icon Read
search

l carnitine fat loss

keyword
https://www.readbyqxmd.com/read/27003444/research-resource-roles-for-calcium-calmodulin-dependent-protein-kinase-kinase-2-camkk2-in-systems-metabolism
#1
Kathrina L Marcelo, Thomas Ribar, Christopher R Means, Anna Tsimelzon, Robert D Stevens, Olga Ilkayeva, James R Bain, Susan G Hilsenbeck, Christopher B Newgard, Anthony R Means, Brian York
A number of epidemiological studies have implicated calcium (Ca(2+)) signaling as a major factor in obesity that contributes to aberrant systems metabolism. Somewhat paradoxically, obesity correlates with decreased circulating Ca(2+) levels, leading to increased release of intracellular Ca(2+) stores from the endoplasmic reticulum. These findings suggest that insulin resistance associated with the obese state is linked to activation of canonical Ca(2+) signaling pathways. Mechanistically, increased intracellular Ca(2+) binds calmodulin (CaM) to activate a set of Ca(2+)/CaM-dependent protein kinases...
May 2016: Molecular Endocrinology
https://www.readbyqxmd.com/read/26953751/upstream-genetic-variant-near-insig2-influences-response-to-carnitine-supplementation-in-bipolar-patients-with-valproate-induced-weight-gain
#2
K Doudney, J A Harley, J F Pearson, A Miller, A Aitchison, M A Kennedy, R J Porter, J L Elmslie, P R Joyce
BACKGROUND: The protein product of INSIG2 is involved in cholesterol and triglyceride metabolism and homeostasis. Variation at rs7566605 near the gene INSIG2 has been associated with increased BMI. OBJECTIVE: To evaluate the effect of rs7566605/INSIG2 genotype on the ability of valproate-treated bipolar patients (BMI ≥ 25 kg/m2) to lose weight using carnitine supplementation during a 26-week lifestyle intervention study. DESIGN: Forty-eight bipolar patients with clinically significant treatment emergent weight gain were genotyped at the rs7566605 SNP...
June 2009: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/26225609/effect-of-feeding-a-weight-loss-food-beyond-a-caloric-restriction-period-on-body-composition-and-resistance-to-weight-gain-in-dogs
#3
RANDOMIZED CONTROLLED TRIAL
Amanda M Floerchinger, Matthew I Jackson, Dennis E Jewell, Jennifer M MacLeay, Inke Paetau-Robinson, Kevin A Hahn
OBJECTIVE: To determine the effect of feeding a food with coconut oil and supplemental L-carnitine, lipoic acid, lysine, leucine, and fiber on weight loss and maintenance in dogs. DESIGN: Prospective clinical study. ANIMALS: 50 overweight dogs. PROCEDURES: The study consisted of 2 trials. During trial 1, 30 dogs were allocated to 3 groups (10 dogs/group) to be fed a dry maintenance dog food to maintain body weight (group 1) or a dry test food at the same amount on a mass (group 2) or energy (group 3) basis as group 1...
August 15, 2015: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/26225608/effect-of-feeding-a-weight-loss-food-beyond-a-caloric-restriction-period-on-body-composition-and-resistance-to-weight-gain-in-cats
#4
RANDOMIZED CONTROLLED TRIAL
Amanda M Floerchinger, Matthew I Jackson, Dennis E Jewell, Jennifer M MacLeay, Kevin A Hahn, Inke Paetau-Robinson
OBJECTIVE: To determine the effect of feeding a food with coconut oil and supplemental L-carnitine, lysine, leucine, and fiber on weight loss and maintenance in cats. DESIGN: Prospective clinical study. ANIMALS: 50 overweight cats. PROCEDURES: The study consisted of 2 trials. During trial 1, 30 cats were allocated to 3 groups (10 cats/group) to be fed a dry maintenance cat food to maintain body weight (group 1) or a dry test food at the same amount on a mass (group 2) or energy (group 3) basis as group 1...
August 15, 2015: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/26056297/impaired-mitochondrial-fat-oxidation-induces-adaptive-remodeling-of-muscle-metabolism
#5
Shawna E Wicks, Bolormaa Vandanmagsar, Kimberly R Haynie, Scott E Fuller, Jaycob D Warfel, Jacqueline M Stephens, Miao Wang, Xianlin Han, Jingying Zhang, Robert C Noland, Randall L Mynatt
The correlations between intramyocellular lipid (IMCL), decreased fatty acid oxidation (FAO), and insulin resistance have led to the hypothesis that impaired FAO causes accumulation of lipotoxic intermediates that inhibit muscle insulin signaling. Using a skeletal muscle-specific carnitine palmitoyltransferase-1 KO model, we show that prolonged and severe mitochondrial FAO inhibition results in increased carbohydrate utilization, along with reduced physical activity; increased circulating nonesterified fatty acids; and increased IMCLs, diacylglycerols, and ceramides...
June 23, 2015: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/25366515/alpha-lipoic-acid-supplementation-reduces-mtorc1-signaling-in-skeletal-muscle-from-high-fat-fed-obese-zucker-rats
#6
Zhuyun Li, Cory M Dungan, Bradley Carrier, Todd C Rideout, David L Williamson
The mammalian target of rapamycin (mTOR) signaling pathway is hyperactive in liver, adipose and skeletal muscle tissues of obese rodents. Alpha-lipoic acid (αLA) has been well accepted as a weight-loss treatment, though there are limited studies on its effect on mTOR signaling in high-fat fed, obese rodents. Therefore, the goal of this study was to determine mTOR signaling and oxidative protein alterations in skeletal muscle of high-fat fed, obese rats after αLA supplementation. Phosphorylation of the mTOR substrate, eukaryotic initiation factor (eIF) 4E-binding protein 1 (4E-BP1) and eIF4B were significantly reduced (p < 0...
December 2014: Lipids
https://www.readbyqxmd.com/read/25348739/carnosic-acid-attenuates-obesity-induced-glucose-intolerance-and-hepatic-fat-accumulation-by-modulating-genes-of-lipid-metabolism-in-c57bl-6j-ob-ob-mice
#7
COMPARATIVE STUDY
Mi-Young Park, Mi-Kyung Sung
BACKGROUND: Carnosic acid (CA), a major bioactive component of rosemary (Rosmarinus officinalis) leaves, is known to possess antioxidant and anti-adipogenic activities. In this study it was hypothesized that CA would ameliorate obesity-induced glucose intolerence and hepatic fat accumulation, and possible mechanisms are suggested. RESULTS: It was observed that a 0.02% (w/w) CA diet effectively decreased body weight, liver weight and blood triglyceride (TG) and total cholesterol levels (P < 0...
March 15, 2015: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/25258426/the-supplementation-of-korean-mistletoe-water-extracts-reduces-hot-flushes-dyslipidemia-hepatic-steatosis-and-muscle-loss-in-ovariectomized-rats
#8
Min Jung Kim, Jong-Heum Park, Dae Young Kwon, Hye Jeong Yang, Da Sol Kim, Suna Kang, Bae Keun Shin, Na Rang Moon, Beom-Seok Song, Jae-Hun Kim, Sunmin Park
Since Korean mistletoe (Viscum album) has been used for alleviating metabolic diseases, it may also prevent the impairment of energy, glucose, lipid, and bone metabolisms in an estrogen-deficient animal model. We determined that long-term consumption of Korean mistletoe water extract (KME) can alleviate menopausal symptoms such as hot flush, increased abdominal fat mass, dyslipidemia, hyperglycemia, and decreased bone mineral density in ovariectomized (OVX) rats fed a high-fat diet, and explored the mechanisms of the effects...
April 2015: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/25016260/history-of-pu-er-tea-and-comparative-study-for-the-effect-of-its-various-extracts-on-lipid-lowering-diet
#9
COMPARATIVE STUDY
Sun Qiong, Yan Xishuang
Pu'er Tea is a kind of traditional historical famous tea which gains its name for native government jurisdiction in Pu'er (now Xishuangbanna in Yunnan, Pu'er city etc), and takes Pu'er (now Ninger county of Pu'er city) city as its collecting and distributing center .It is famous all over the world because of its good benefits for reducing blood lipid, slimming weight, antibacterial, aid digestion, detoxification and other functions, it is even known as the health care beverage with "the fine quality goods for preserving people's health", "a health drink demanded everyday"...
July 2014: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/24953351/l-carnitine-supplementation-impairs-endothelium-dependent-relaxation-in-mesenteric-arteries-from-rats
#10
Carmem P Valgas da Silva, Julio A Rojas-Moscoso, Edson Antunes, Angelina Zanesco, Fernanda B M Priviero
L-Carnitine (L-Car) is taken as fat burner. The risks of L-Car supplementation for the cardiovascular system are unclear. We evaluated the relaxing responses of the mesenteric and aorta rings from rats after four weeks of L-Car supplementation and/or physical training. Concentration response curves to acetylcholine (ACh) and sodium nitroprusside (SNP), as well as cyclic GMP levels, superoxide dismutase (SOD) activity and malondialdehyde (MDA) were evaluated. Physical training decreased body weight gain that was potentiated by L-Car...
July 2014: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/24904670/dietary-and-nutraceutical-approach-to-type-2-diabetes
#11
Giuseppe Derosa, Celina Preciado Limas, Pilar Ceballos Macías, Aceves Estrella, Pamela Maffioli
Nutritional medical treatment is the first step to achieve adequate glycemic control and prevent diabetic complications. Lifestyle changes include moderate weight loss (7%) and regular physical activity (150 min/week). The appropriate diet composition is < 30% total fat, < 10% saturated fats, > 15 g/1000 kcal fiber, half soluble, 45-60% of carbohydrates with amoderate intake of sugar (50 g/day) and protein intake of 15-20% of the total calories a day. Patients need to limit the intake of saturated fats to < 7% of the daily calorie intake...
May 12, 2014: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/24312551/enteric-neuropathy-can-be-induced-by-high-fat-diet-in-vivo-and-palmitic-acid-exposure-in-vitro
#12
Ulrikke Voss, Elin Sand, Björn Olde, Eva Ekblad
OBJECTIVE: Obese and/or diabetic patients have elevated levels of free fatty acids and increased susceptibility to gastrointestinal symptoms. Since the enteric nervous system is pivotal in regulating gastrointestinal functions alterations or neuropathy in the enteric neurons are suspected to occur in these conditions. Lipid induced intestinal changes, in particular on enteric neurons, were investigated in vitro and in vivo using primary cell culture and a high fat diet (HFD) mouse model...
2013: PloS One
https://www.readbyqxmd.com/read/23658353/effects-of-dietary-l-carnitine-and-dried-distillers-grains-with-solubles-on-growth-carcass-characteristics-and-loin-and-fat-quality-of-growing-finishing-pigs
#13
W Ying, M D Tokach, J M DeRouchey, T E Houser, S S Dritz, R D Goodband, J L Nelssen
A total of 1104 barrows and gilts (PIC 337 × 1050, Pig Improvement Company, Hendersonville, TN), weighing 36 ± 1 kg were used in a 109-d study to evaluate effects of dietary L-carnitine and dried distillers grains with solubles (DDGS) on growth, carcass traits, and loin and fat quality. Pigs were blocked by BW and randomly assigned to 1 of 6 treatments, with 7 pens per treatment. Treatments were arranged as a 2 × 3 factorial, with main effects of DDGS (30% in Phases 1, 2, and 3, and 20% in Phase 4) and L-carnitine (0, 50, or 100 mg/kg)...
July 2013: Journal of Animal Science
https://www.readbyqxmd.com/read/23539345/liver-fatty-acid-binding-protein-gene-ablation-exacerbates-weight-gain-in-high-fat-fed-female-mice
#14
Avery L McIntosh, Barbara P Atshaves, Danilo Landrock, Kerstin K Landrock, Gregory G Martin, Stephen M Storey, Ann B Kier, Friedhelm Schroeder
Loss of liver fatty acid binding protein (L-FABP) decreases long chain fatty acid uptake and oxidation in primary hepatocytes and in vivo. On this basis, L-FABP gene ablation would potentiate high-fat diet-induced weight gain and weight gain/energy intake. While this was indeed the case when L-FABP null (-/-) mice on the C57BL/6NCr background were pair-fed a high-fat diet, whether this would also be observed under high-fat diet fed ad libitum was not known. Therefore, this possibility was examined in female L-FABP (-/-) mice on the same background...
May 2013: Lipids
https://www.readbyqxmd.com/read/23527196/leucine-and-protein-metabolism-in-obese-zucker-rats
#15
Pengxiang She, Kristine C Olson, Yoshihiro Kadota, Ayami Inukai, Yoshiharu Shimomura, Charles L Hoppel, Sean H Adams, Yasuko Kawamata, Hideki Matsumoto, Ryosei Sakai, Charles H Lang, Christopher J Lynch
Branched-chain amino acids (BCAAs) are circulating nutrient signals for protein accretion, however, they increase in obesity and elevations appear to be prognostic of diabetes. To understand the mechanisms whereby obesity affects BCAAs and protein metabolism, we employed metabolomics and measured rates of [1-(14)C]-leucine metabolism, tissue-specific protein synthesis and branched-chain keto-acid (BCKA) dehydrogenase complex (BCKDC) activities. Male obese Zucker rats (11-weeks old) had increased body weight (BW, 53%), liver (107%) and fat (∼300%), but lower plantaris and gastrocnemius masses (-21-24%)...
2013: PloS One
https://www.readbyqxmd.com/read/23523884/effect-of-metformin-on-the-urinary-metabolites-of-diet-induced-obese-mice-studied-by-ultra-performance-liquid-chromatography-coupled-to-time-of-flight-mass-spectrometry-uplc-tof-ms
#16
Yunyun Zhu, Yi Feng, Lan Shen, Desheng Xu, Bin Wang, Kefeng Ruan, Wenjuan Cong
Obesity is becoming a health concern worldwide and metformin, a first line anti-diabetic drug, was associated with weight loss under different backgrounds. However, most researches focused on the anti-diabetic mechanism and less attention has been paid on the mechanism of weight loss of metformin. Therefore, we established a metabonomic method to evaluate metformin action in preventing obesity in a high fat diet-induced-obesity (DIO) mice model. 36 male C57BL/6 mice (8-week old) were randomly divided into control group (n=12, normal chow), model group (n=12, high fat chow) and metformin group (n=12, high fat chow and dosed with metformin) over 16 weeks...
April 15, 2013: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/23473237/effects-of-l-carnitine-supplementation-to-suckling-piglets-on-carcass-and-meat-quality-at-market-age
#17
D Lösel, C Rehfeldt
In a previous study, carnitine supplementation to piglets during the suckling period resulted in an increased total muscle fibre number at weaning in piglets of low birth weight. The objective of the present study was to investigate whether this effect is maintained until market age and whether this would attenuate the negative consequences of low birth weight on carcass and meat quality. Using a split-plot design with litter as block, sex as whole plot and treatment as subplot, the effects of early-postnatal l-carnitine supplementation on female and castrated male piglets of low birth weight were investigated on a total of 56 German Landrace piglets from 14 litters...
July 2013: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/23422010/interactive-effects-of-dietary-ractopamine-hcl-and-l-carnitine-on-finishing-pigs-ii-carcass-characteristics-and-meat-quality
#18
B W James, M D Tokach, R D Goodband, J L Nelssen, S S Dritz, K Q Owen, J C Woodworth, R C Sulabo
Three experiments using 1,356 pigs (C22 × 336 PIC) were conducted to determine the interactive effects of dietary L-carnitine and ractopamine hydrochloride (RAC) on carcass characteristics and meat quality of finishing pigs. Experiments were arranged as factorials with main effects of L-carnitine and RAC; L-carnitine levels were 0, 25, or 50 mg/kg in Exp. 1 and 2 and 0 or 50 mg/kg in Exp. 3, and RAC levels of 0, 5, or 10 mg/kg in Exp. 1 and 0 or 10 mg/kg in Exp. 2 and 3. Dietary L-carnitine was fed from 38 kg to slaughter (109 and 118 kg in Exp...
July 2013: Journal of Animal Science
https://www.readbyqxmd.com/read/23271695/improvement-in-insulin-resistance-and-favourable-changes-in-plasma-inflammatory-adipokines-after-weight-loss-associated-with-two-months-consumption-of-a-combination-of-bioactive-food-ingredients-in-overweight-subjects
#19
RANDOMIZED CONTROLLED TRIAL
Mariangela Rondanelli, Annalisa Opizzi, Simone Perna, Milena Faliva, Sebastiano Bruno Solerte, Marisa Fioravanti, Catherine Klersy, Edda Cava, Cava Edda, Maddalena Paolini, Paolini Maddalena, Luciano Scavone, Scavone Luciano, Paola Ceccarelli, Ceccarelli Paola, Emanuela Castellaneta, Castellaneta Emanuela, Claudia Savina, Savina Claudia, Lorenzo Maria Donini
This randomized, double blind, placebo-controlled, 8 week trial assessed the efficacy on metabolic changes produced by a consumption of a combination of bioactive food ingredients (epigallocatechin gallate, capsaicins, piperine and L-carnitine) versus a placebo, as part of a therapeutic 'lifestyle change' diet, in 86 overweight subjects. Forty-one patients (2/14 F/M; age 43.7 ± 8.5; BMI 30.3 ± 3.5 kg/m(2)) were randomized to the supplemented group and 45 (29/16; age 40.7 ± 10.2; BMI 30.0 ± 2.7) to the control group...
October 2013: Endocrine
https://www.readbyqxmd.com/read/22824168/l-carnitine-supplementation-in-advanced-pancreatic-cancer-carpan-a-randomized-multicentre-trial
#20
RANDOMIZED CONTROLLED TRIAL
Matthias Kraft, Kathleen Kraft, Simone Gärtner, Julia Mayerle, Peter Simon, Eckhard Weber, Kerstin Schütte, Jens Stieler, Heide Koula-Jenik, Peter Holzhauer, Uwe Gröber, Georg Engel, Cornelia Müller, You-Shan Feng, Ali Aghdassi, Claudia Nitsche, Peter Malfertheiner, Maciej Patrzyk, Thomas Kohlmann, Markus M Lerch
BACKGROUND: Cachexia, a >10% loss of body-weight, is one factor determining the poor prognosis of pancreatic cancer. Deficiency of L-Carnitine has been proposed to cause cancer cachexia. FINDINGS: We screened 152 and enrolled 72 patients suffering from advanced pancreatic cancer in a prospective, multi-centre, placebo-controlled, randomized and double-blinded trial to receive oral L-Carnitine (4 g) or placebo for 12 weeks. At entry patients reported a mean weight loss of 12 ± 2...
2012: Nutrition Journal
keyword
keyword
103384
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"