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https://www.readbyqxmd.com/read/28222365/the-cessation-of-the-long-term-exposure-to-low-doses-of-mercury-ameliorates-the-increase-in-systolic-blood-pressure-and-vascular-damage-in-rats
#1
Danize Aparecida Rizzetti, João Guilherme Dini Torres, Alyne Goulart Escobar, Taiz Martins da Silva, Paola Zambelli Moraes, Raquel Hernanz, Franck Maciel Peçanha, Marta Miguel Castro, Dalton Valentim Vassallo, Mercedes Salaices, Maria Jesús Alonso, Giulia Alessandra Wiggers
This study aimed to verify whether a prolonged exposure to low-level mercury promotes haemodynamic disorders and studied the reversibility of this vascular damage. Rats were divided into seven groups: three control groups received saline solution (im) for 30, 60 or 90 days; two groups received HgCl2 (im, first dose, 4.6μg/kg, subsequent doses 0.07μg/kg/day) for 30 or 60 days; two groups received HgCl2 for 30 or 60 days (im, same doses) followed by a 30-day washout period. Systolic blood pressure (SBP) was measured, along with analysis of vascular response to acetylcholine (ACh) and phenylephrine (Phe) in the absence and presence of endothelium, a nitric oxide (NO) synthase inhibitor, an NADPH oxidase inhibitor, superoxide dismutase, a non-selective cyclooxygenase (COX) inhibitor and an AT1 receptor blocker...
February 18, 2017: Environmental Research
https://www.readbyqxmd.com/read/28222146/cytotoxic-effector-functions-of-t-cells-are-not-required-for-protective-immunity-against-fatal-rickettsia-typhi-infection-in-a-murine-model-of-infection-role-of-th1-and-th17-cytokines-in-protection-and-pathology
#2
Kristin Moderzynski, Liza Heine, Jessica Rauch, Stefanie Papp, Svenja Kuehl, Ulricke Richardt, Bernhard Fleischer, Anke Osterloh
Endemic typhus caused by Rickettsia (R.) typhi is an emerging febrile disease that can be fatal due to multiple organ pathology. Here we analyzed the requirements for protection against R. typhi by T cells in the CB17 SCID model of infection. BALB/c wild-type mice generate CD4+ TH1 and cytotoxic CD8+ T cells both of which are sporadically reactivated in persistent infection. Either adoptively transferred CD8+ or CD4+ T cells protected R. typhi-infected CB17 SCID mice from death and provided long-term control...
February 21, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28222054/ucp2-expression-is-increased-in-pancreas-from-brain-dead-donors-and-involved-in-cytokine-induced-%C3%AE-cells-apoptosis
#3
Leticia A Brondani, Tatiana H Rech, Gabriela Boelter, Andrea C Bauer, Cristiane B Leitão, Décio L Eizirik, Daisy Crispim
BACKGROUND: Systemic inflammation associated with brain death (BD) decreases islet yield and quality, negatively affecting outcomes of human islet transplantation. A recent study from our group showed an increased expression of uncoupling protein-2 (UCP2) in pancreas from rats with BD as compared with controls. UCP2 is located in the mitochondrial inner membrane and regulates production of reactive oxygen species and glucose-stimulated insulin secretion. It has been suggested that UCP2 also plays a role in β cell apoptosis, but these findings remain controversial...
March 2017: Transplantation
https://www.readbyqxmd.com/read/28222024/eff-ects-of-hemin-a-heme-oxygenase-1-inducer-in-l-arginine-induced-acute-pancreatitis-and-associated-lung-injury-in-adult-male-albino-rats
#4
N M Aziz, M Y Kamel, R A Rifaai
OBJECTIVE: The aim of the current study was to assess the protective outcome of hemin, a heme oxygenase-1 (HO-1) inducer on L-arginine-induced acute pancreatitis in rats. Acute pancreatitis (AP) is considered to be a critical inflammatory disorder with a major impact on the patient health. Various theories have been recommended regarding the pathophysiology of AP and associated pulmonary complications. METHODS: Twenty-four adult male albino rats were randomly divided into four groups: control group, acute pancreatitis (AP), hemin pre-treated AP group, and hemin post-treated AP group...
January 1, 2017: Endocrine Regulations
https://www.readbyqxmd.com/read/28221973/a-bioprocessed-polysaccharide-from-lentinus-edodes-mycelia-cultures-with-turmeric-protects-chicks-from-a-lethal-challenge-of-salmonella-gallinarum
#5
Dalmuri Han, Hyung Tae Lee, June Bong Lee, Yongbaek Kim, Sang Jong Lee, Jang Won Yoon
Our previous studies demonstrated that a bioprocessed polysaccharide (BPP) isolated from Lentinus edodes mushroom mycelia cultures supplemented with black rice bran can protect mice against Salmonella lipopolysaccharide-induced endotoxemia and reduce the mortality from Salmonella Typhimurium infection through upregulated T-helper 1 immunity. Here, we report that a BPP from L. edodes mushroom mycelia liquid cultures supplemented with turmeric (referred to as BPP-turmeric) alters chicken macrophage responses against avian-adapted Salmonella Gallinarum and protects chicks against a lethal challenge from Salmonella Gallinarum...
February 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28221817/neuroprotective-effect-of-omega-3-polyunsaturated-fatty-acids-in-the-6-ohda-model-of-parkinson-s-disease-is-mediated-by-a-reduction-of-inducible-nitric-oxide-synthase
#6
Marco Aurélio Mori, Ana Marcia Delattre, Bruno Carabelli, Claudia Pudell, Mariza Bortolanza, Pedro Vinícius Staziaki, Jesuí Vergilio Visentainer, Paula Fernandes Montanher, Elaine A Del Bel, Anete Curte Ferraz
OBJECTIVE: Parkinson's disease (PD) is characterized by deterioration of the nigrostriatal system and associated with chronic neuroinflammation. Glial activation has been associated with regulating the survival of dopaminergic neurons and is thought to contribute to PD through the release of proinflammatory and neurotoxic factors, such as reactive nitric oxide (NO) that triggers or exacerbates neurodegeneration in PD. Polyunsaturated fatty acids (PUFAs) exert protective effects, including antiinflammatory, antiapoptotic, and antioxidant activity, and may be promising for delaying or preventing PD by attenuating neuroinflammation and preserving dopaminergic neurons...
February 21, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28221737/feasibility-of-multiple-breath-washout-measurements-in-infants-with-bronchiolitis-a-pilot-study
#7
Patrick Stafler, Sigal Weinreb, Huda Mussaffi, Meir Mei-Zahav, Dario Prais, Guy Steuer, Ophir Bar-On, Moshe Hoshen, Hannah Blau
BACKGROUND: Lung clearance index (LCI) reflects ventilation inhomogeneity and is raised in obstructive airway disease. Feasibility of multiple breath washout (MBW) measurement during acute lung disease in infants is unknown. As a further measure of disease, exhaled nitric oxide (eNO) may paradoxically decrease in acute bronchiolitis. We hypothesized that MBW measurements were attainable in infants with bronchiolitis and that LCI was raised and eNO reduced, compared to normal controls...
February 21, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28221702/localized-and-controlled-delivery-of-nitric-oxide-to-the-conventional-outflow-pathway-via-enzyme-biocatalysis-toward-therapy-for-glaucoma
#8
Rona Chandrawati, Jason Y H Chang, Ester Reina-Torres, Coline Jumeaux, Joseph M Sherwood, W Daniel Stamer, Alexander N Zelikin, Darryl R Overby, Molly M Stevens
Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location- and dose-dependent. An NO delivery platform that directly targets the resistance-generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28220965/defect-edge-selective-functionalization-of-carbon-materials-by-direct-friedel-crafts-acylation-reaction
#9
REVIEW
Jeong-Min Seo, Loon-Seng Tan, Jong-Beom Baek
Popularly utilized oxidation media, via nitric acid/sulfuric acid mixtures, are too corrosive and oxidizing to preserve structural integrity of highly ordered graphitic materials (carbon nanotubes (CNTs) and graphene). Here, for the most commonly used oxidation method, the important advantages of defect/edge-selective functionalization of carbon materials (CNTs/graphene/graphite) in a polyphosphoric acid (PPA)/phosphorous pentoxide (P2 O5 ) medium are elucidated. The optimized PPA/P2 O5 medium is a mild acid that is not only less corrosive than popularly utilized oxidation media, but also has a strong capability to drive Friedel-Crafts acylation by covalently modifying carbon materials...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28220904/recent-advances-in-occupational-and-environmental-health-hazards-of-workers-exposed-to-gasoline-compounds
#10
REVIEW
Christopher E Ekpenyong, Asuquo E Asuquo
The impact of health and environmental hazards, associated with the constituents of gasoline, on occupationally exposed workers has been recorded over the past few decades. However, the scientific literature on their pathogenic potential remains incomplete, which could affect the current understanding of the associated health risks. This review provides current information based on recently improved research techniques to evaluate gasoline toxicity profiles for humans. Our current knowledge provides insight into the intricate mechanism of gasoline-induced adverse effects, including the formation of reactive metabolites via bio-activation and subsequent generation of reactive oxygen species (ROS) and oxidative stress, which are involved in multiple mechanisms that are central to the aetiology of gasoline-induced toxicity...
February 21, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28220869/nitric-oxide-is-involved-in-the-oxytetracycline-induced-suppression-of-root-growth-through-inhibiting-hydrogen-peroxide-accumulation-in-the-root-meristem
#11
Qing-Xiang Yu, Golam Jalal Ahammed, Yan-Hong Zhou, Kai Shi, Jie Zhou, Yunlong Yu, Jing-Quan Yu, Xiao-Jian Xia
Use of antibiotic-contaminated manure in crop production poses a severe threat to soil and plant health. However, few studies have studied the mechanism by which plant development is affected by antibiotics. Here, we used microscopy, flow cytometry, gene expression analysis and fluorescent dyes to study the effects of oxytetracycline (OTC), a widely used antibiotic in agriculture, on root meristem activity and the accumulation of hydrogen peroxide (H2O2) and nitric oxide (NO) in the root tips of tomato seedlings...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220834/stellera-chamaejasme-and-its-constituents-induce-cutaneous-wound-healing-and-anti-inflammatory-activities
#12
Myungsuk Kim, Hee Ju Lee, Ahmad Randy, Ji Ho Yun, Sang-Rok Oh, Chu Won Nho
Stellera chamaejasme L. (Thymelaeaceae) is a perennial herb that is widely used in traditional Chinese medicine to treat tumours, tuberculosis and psoriasis. S. chamaejasme extract (SCE) possesses anti-inflammatory, analgesic and wound healing activities; however, the effect of S. chamaejasme and its active compounds on cutaneous wound healing has not been investigated. We assessed full-thickness wounds of Sprague-Dawley (SD) rats and topically applied SCE for 2 weeks. In vitro studies were performed using HaCaT keratinocytes, Hs68 dermal fibroblasts and RAW 264...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220127/nitric-oxide-ameliorates-zinc-oxide-nanoparticles-phytotoxicity-in-wheat-seedlings-implication-of-the-ascorbate-glutathione-cycle
#13
Durgesh K Tripathi, Rohit K Mishra, Swati Singh, Samiksha Singh, Kanchan Vishwakarma, Shivesh Sharma, Vijay P Singh, Prashant K Singh, Sheo M Prasad, Nawal K Dubey, Avinash C Pandey, Shivendra Sahi, Devendra K Chauhan
The present study investigates ameliorative effects of nitric oxide (NO) against zinc oxide nanoparticles (ZnONPs) phytotoxicity in wheat seedlings. ZnONPs exposure hampered growth of wheat seedlings, which coincided with reduced photosynthetic efficiency (Fv/Fm and qP), due to increased accumulation of zinc (Zn) in xylem and phloem saps. However, SNP supplementation partially mitigated the ZnONPs-mediated toxicity through the modulation of photosynthetic activity and Zn accumulation in xylem and phloem saps...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28220034/exhaled-and-nasal-nitric-oxide-in-relation-to-lung-function-blood-cell-counts-and-disease-characteristics-in-cystic-fibrosis
#14
Christina Krantz, Christer Janson, Annika Hollsing, Kjell Alving, Andrei Malinovschi
BACKGROUND: Patients with CF have similar or lower exhaled nitric oxide (FeNO) and lower nasal nitric oxide (nNO) levels than controls. There are divergent results on alveolar NO (CalvNO) concentrations in relation to CF. There are inconsistent results on correlation between different nitric oxide parameters and lung function and inflammation in CF. AIM: To compare FeNO, CalvNO and nNO levels between subjects with CF, asthma and healthy controls and to study whether these parameters are related to lung function, blood cell counts or clinical characteristics in CF patients...
February 21, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/28220030/novel-paradigms-of-salt-and-hypertension
#15
Wenguang Feng, Louis J Dell'Italia, Paul W Sanders
Salt resistance/sensitivity refers specifically to the effect of dietary sodium chloride (salt) intake on BP. Increased dietary salt intake promotes an early and uniform expansion of extracellular fluid volume and increased cardiac output. To compensate for these hemodynamic changes and maintain constant BP in salt resistance, renal and peripheral vascular resistance falls and is associated with an increase in production of nitric oxide. In contrast, the decline in peripheral vascular resistance and the increase in nitric oxide are impaired or absent in salt sensitivity, promoting an increase in BP in these individuals...
February 20, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28219839/sinigrin-inhibits-production-of-inflammatory-mediators-by-suppressing-nf-%C3%AE%C2%BAb-mapk-pathways-or-nlrp3-inflammasome-activation-in-macrophages
#16
Hee-Weon Lee, Chung Gi Lee, Dong-Kwon Rhee, Sung Hee Um, Sukneung Pyo
Sinigrin (2-propenyl glucosinolate) is found mainly in broccoli, brussels sprouts, and black mustard seeds. Recently, sinigrin has received attention for its role in disease prevention and health. This study investigated the effect of sinigrin on macrophage function, including the activity of Nod-like receptor protein 3 (NLRP3) inflammasome. In a concentration-dependent manner, sinigrin inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) production and the expression of COX-2 and prostaglandin E2 (PGE2) in RAW 264...
February 17, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28219747/is-pulmonary-diffusion-capacity-for-nitric-oxide-dl-no-likely-to-become-a-routine-pulmonary-function-test
#17
Irene Steenbruggen, Frans de Jongh
DL,CO measurements are often used to evaluate and monitor lung diseases as well as cardiovascular diseases. Whether the combination of DL,CO and DL,NO will improve the management of cardiovascular diseases needs to be investigated. It is hoped that the standardization of the DL,NO measurement will facilitate research. Scientific evidence that DL,NO can provide more accurate information than DL,CO alone, can take away the barriers that prevents DL,NO to become a routine test in pulmonology.
February 17, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28219722/regulation-and-control-of-nitric-oxide-no-in-macrophages-protecting-the-professional-killer-cell-from-its-own-cytotoxic-arsenal-via-mrp1-and-gstp1
#18
REVIEW
Z Kovacevic, S Sahni, H Lok, M J Davies, D A Wink, D R Richardson
We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-MØ) models from large quantities of endogenous NO. This system stores and transports NO as dinitrosyl-dithiol-iron complexes (DNICs) composed of iron, NO and glutathione (GSH). Hence, this gas with contrasting anti- and pro-tumor effects, which has been assumed to be a freely diffusible, is a tightly-regulated species in M1-MØs...
February 17, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28219701/amelioratory-effect-of-coenzyme-q10-on-potential-human-carcinogen-microcystin-lr-induced-toxicity-in-mice
#19
Yaqoob Lone, Mangla Bhide, Raj Kumar Koiri
Microcystins are a group of cyclic heptapeptide toxins produced by cyanobacteria. More than 100 microcystin analogues have been detected, among which microcystin-LR is the most abundant and toxic variant. Present study was designed to reveal whether potential human carcinogen microcystin-LR could imbalance the glycolytic-oxidative-nitrosative status of heart, kidney and spleen of mice and also to explore the amelioratory effect of coenzyme Q10 on microcystin-LR induced toxicity. Microcystin-LR was administered at a dose of 10 μg/kg bw/day, ip for 14 days in male mice...
February 17, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28219355/vaccaria-hypaphorine-alleviates-lipopolysaccharide-induced-inflammation-via-inactivation-of-nf%C3%AE%C2%BAb-and-erk-pathways-in-raw-264-7-cells
#20
Haijian Sun, Weiwei Cai, Xu Wang, Yanling Liu, Bao Hou, Xuexue Zhu, Liying Qiu
BACKGROUND: Activation of macrophage is involved in many inflammation diseases. Lipopolysaccharide (LPS) is a powerful inflammatory signal contributing to monocytes/macrophages activation associated with increased proinflammatory cytokines expressions. We recently identified that vaccarin was expected to protect endothelial cells from injury. Hypaphorine was abundantly found in vaccaria semen. However, the potential roles and underlying mechanisms of vaccaria hypaphorine on macrophage inflammation have been poorly defined...
February 20, 2017: BMC Complementary and Alternative Medicine
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