keyword
MENU ▼
Read by QxMD icon Read
search

NCBI

keyword
https://www.readbyqxmd.com/read/28427473/intestinal-beh%C3%A3-et-and-crohn-s-disease-two-sides-of-the-same-coin
#1
REVIEW
Simona Valenti, Romina Gallizzi, Dominique De Vivo, Claudio Romano
Behçet's disease (BD) and Crohn's disease (CD) are chronic immune-mediated, inflammatory disorders affecting many different systems (joints, skin, eyes, gastrointestinal and biliary tracts). Both disorders have fluctuating courses and when gastrointestinal symptoms are prevalent, differential diagnosis can be difficult. BD involves the gastrointestinal tract in 10-15% of cases with localized lesions in the ileocecal region. The clinical picture is heterogeneous with various clusters of disease expression. CD is a chronic inflammatory disorder, which can affect any part of the intestinal tract, as well as extra-intestinal tissue...
April 20, 2017: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/28427159/genome-wide-analysis-of-long-noncoding-rna-and-mrna-co-expression-profile-in-intrahepatic-cholangiocarcinoma-tissue-by-rna-sequencing
#2
Wenhui Yang, Yuan Li, Xia Song, Jun Xu, Jun Xie
Long noncoding RNAs (lncRNAs), which are pervasively transcribed in the genome, are emerging in molecular biology as crucial regulators of cancer. RNA-seq data were downloaded from GEO of NCBI and further analyzed to identify novel targets in intrahepatic cholangiocarcinoma (iCCA).We investigated differences in lncRNA and mRNA profiles between 7 pairs of iCCA and adjacent normal tissues. 230 lncRNAs were differentially expressed more than four-fold change in iCCA tissues. Among these, 97 were upregulated and 133 downregulated relatively to normal tissues...
February 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28424939/characterization-and-complete-genome-sequence-of-a-novel-siphoviridae-bacteriophage-bs5
#3
Xue Meng, Min Wang, Siyuan You, Duobing Wang, Yan Li, Zhaoyang Liu, Yu Gao, Lu Liu, Yaoyuan Zhang, Zhenghao Yan, Chunyan Liu, Yong Jiang, Hongbing Shao
A novel Siphoviridae family Phage BS5, which infects Pseudoalteromonas atlantica, was isolated from the surface waters of the Yellow Sea. Morphological study by transmission electron microscopy revealed that the novel phage belongs to Siphoviridae. The complete genome sequence of PBS5 contained a linear, double-strand 39949-bp DNA molecule with a G + C content of 40.6% and 65 putative open reading frames. Twelve conserved domains were detected by BLASTP in NCBI, and of these the functions of 5 were known...
April 20, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28424938/characterization-and-genome-sequence-of-marine-alteromonas-gracilis-phage-pb15-isolated-from-the-yellow-sea-china
#4
Yu Gao, Qian Liu, Min Wang, Guihua Zhao, Yong Jiang, Gill Malin, Zheng Gong, Xue Meng, Zhaoyang Liu, Tongtong Lin, Yutong Li, Hongbing Shao
A novel marine Alteromonas gracilis siphovirus, phage PB15, was isolated from the surface water of the Yellow Sea in August 2015. It has a head diameter of 58 ± 5 nm head and a contractile tail approximately 105 ± 10 nm in length, and overall, the morphology suggests that PB15 belongs to the family Siphoviridae. PB15 phage is stable at over the temperature range 0-60 °C. The best MOI of these phage was 0.1, and infectivity decreased above 60 °C. The results suggest that phage is stable at pH value ranging between 3...
April 20, 2017: Current Microbiology
https://www.readbyqxmd.com/read/28422050/k-mer-content-correlation-and-position-analysis-of-genome-dna-sequences-for-the-identification-of-function-and-evolutionary-features
#5
Aaron Sievers, Katharina Bosiek, Marc Bisch, Chris Dreessen, Jascha Riedel, Patrick Froß, Michael Hausmann, Georg Hildenbrand
In genome analysis, k-mer-based comparison methods have become standard tools. However, even though they are able to deliver reliable results, other algorithms seem to work better in some cases. To improve k-mer-based DNA sequence analysis and comparison, we successfully checked whether adding positional resolution is beneficial for finding and/or comparing interesting organizational structures. A simple but efficient algorithm for extracting and saving local k-mer spectra (frequency distribution of k-mers) was developed and used...
April 19, 2017: Genes
https://www.readbyqxmd.com/read/28421062/identification-of-rare-pb2-d701n-mutation-from-a-patient-with-severe-influenza-contribution-of-the-pb2-d701n-mutation-to-the-pathogenicity-of-human-influenza
#6
Amelia Nieto, Francisco Pozo, Matxalen Vidal-García, Manuel Omeñaca, Inmaculada Casas, Ana Falcón
Several amino acid changes have been previously implicated in adaptation of avian influenza viruses to human hosts, among them the D701N change in the PB2 polymerase subunit that also is the main determinant of avian virus pathogenesis in animal models. However, previous studies using recombinant viruses did not provide conclusive information of the contribution of this PB2 residue to pathogenicity in human influenza virus strains. We identified this mutation in an A(H1N1)pdm09-like human influenza virus isolated from an infected patient with pneumonia and acute respiratory failure, admitted to the intensive care unit...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28420927/in-silico-analysis-of-fragile-histidine-triad-involved-in-regression-of-carcinoma
#7
Muhammad Asif Rasheed, Fatima Tariq, Sara Afzal, Shazia Mannanv
Hepatocellular carcinoma (HCCa) is a primary malignancy of the liver. Many different proteins are involved in HCCa including insulin growth factor (IGF) II , signal transducers and activators of transcription (STAT) 3, STAT4, mothers against decapentaplegic homolog 4 (SMAD 4), fragile histidine triad (FHIT) and selective internal radiation therapy (SIRT) etc. The present study is based on the bioinformatics analysis of FHIT protein in order to understand the proteomics aspect and improvement of the diagnosis of the disease based on the protein...
April 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28418904/a-consensus-hemagglutinin-based-vaccine-delivered-by-an-attenuated-salmonella-mutant-protects-chickens-against-heterologous-h7n1-influenza-virus
#8
Kim Je Hyoung, Irshad Ahmed Hajam, John Hwa Lee
H7N3 and H7N7 are highly pathogenic avian influenza (HPAI) viruses and have posed a great threat not only for the poultry industry but for the human health as well. H7N9, a low pathogenic avian influenza (LPAI) virus, is also highly pathogenic to humans, and there is a great concern that these H7 subtypes would acquire the ability to spread efficiently between humans, thereby becoming a pandemic threat. A vaccine candidate covering all the three subtypes must, therefore, be an integral part of any pandemic preparedness plan...
March 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413781/sequencing-and-de-novo-transcriptome-assembly-of-the-chinese-giant-salamander-andrias-davidianus
#9
Yong Huang, Xiao Chan Gao, Jian Li Xiong, Hong Tao Ren, Xi Hong Sun
Next-generation technologies for determination of genomics and transcriptomics composition have a wide range of applications. Andrias davidianus, has become an endangered amphibian species of salamander endemic in China. However, there is a lack of the molecular information. In this study, we obtained the RNA-Seq data from a pool of A. davidianus tissue including spleen, liver, muscle, kidney, skin, testis, gut and heart using Illumina HiSeq 2500 platform. A total of 15,398,997,600 bp were obtained, corresponding to 102,659,984 raw reads...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28413726/gb4gv-a-genome-browser-for-geminivirus
#10
Eric S Ho, Catherine M Newsom-Stewart, Lysa Diarra, Caroline S McCauley
BACKGROUND: Geminiviruses (family Geminiviridae) are prevalent plant viruses that imperil agriculture globally, causing serious damage to the livelihood of farmers, particularly in developing countries. The virus evolves rapidly, attributing to its single-stranded genome propensity, resulting in worldwide circulation of diverse and viable genomes. Genomics is a prominent approach taken by researchers in elucidating the infectious mechanism of the virus. Currently, the NCBI Viral Genome website is a popular repository of viral genomes that conveniently provides researchers a centralized data source of genomic information...
2017: PeerJ
https://www.readbyqxmd.com/read/28413616/-a-curated-transcriptomic-dataset-collection-relevant-to-embryonic-development-associated-with-in-vitro-fertilization-in-healthy-individuals-and-patients-with-polycystic-ovary-syndrome
#11
Rafah Mackeh, Sabri Boughorbel, Damien Chaussabel, Tomoshige Kino
The collection of large-scale datasets available in public repositories is rapidly growing and providing opportunities to identify and fill gaps in different fields of biomedical research. However, users of these datasets should be able to selectively browse datasets related to their field of interest. Here we made available a collection of transcriptome datasets related to human follicular cells from normal individuals or patients with polycystic ovary syndrome, in the process of their development, during in vitro fertilization...
2017: F1000Research
https://www.readbyqxmd.com/read/28412964/mesh-now-automatic-mesh-indexing-at-pubmed-scale-via-learning-to-rank
#12
Yuqing Mao, Zhiyong Lu
BACKGROUND: MeSH indexing is the task of assigning relevant MeSH terms based on a manual reading of scholarly publications by human indexers. The task is highly important for improving literature retrieval and many other scientific investigations in biomedical research. Unfortunately, given its manual nature, the process of MeSH indexing is both time-consuming (new articles are not immediately indexed until 2 or 3 months later) and costly (approximately ten dollars per article). In response, automatic indexing by computers has been previously proposed and attempted but remains challenging...
April 17, 2017: Journal of Biomedical Semantics
https://www.readbyqxmd.com/read/28410921/a-randomized-trial-to-determine-the-impact-of-a-digestion-resistant-starch-composition-on-the-gut-microbiome-in-older-and-mid-age-adults
#13
Michelle J Alfa, David Strang, Paramjit S Tappia, Morag Graham, Gary Van Domselaar, Jessica D Forbes, Vanessa Laminman, Nancy Olson, Pat DeGagne, David Bray, Brenda-Lee Murray, Brenden Dufault, Lisa M Lix
BACKGROUND: The elderly often have a diet lacking resistant starch (RS) which is thought to lead to gut microbiome dysbiosis that may result in deterioration of gut colonocytes. OBJECTIVE: The primary objective was to assess if elderly (ELD; ≥ 70 years age) had microbiome dysbiosis compared to mid-age (MID; 30-50 years age) adults and then determine the impact of daily consumption of MSPrebiotic(®) (a RS) or placebo over 3 months on gut microbiome composition...
March 31, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28409117/searching-for-active-mobile-genetic-elements-in-dsrna-fraction-of-pinus-sylvestris-having-witches-broom-abnormalities
#14
A A Pochtovyy, O Yu Baranov, I E Rubel', O A Razumova, V E Padutov, A V Khromov, A V Makhotenko, A P Tkachuk, V V Makarov, V A Gushchin
The most common type of coniferous mobile genetic elements are retrotransposons. Despite of their early positive impact on evolution of modern coniferous species they can have a significant negative impact for Forestry and breeding. Breaking genomic structural integrity mobile elements can cause phenotypic defects of plants. In this regard, the study of the diversity of coniferous mobile genetic elements is particularly interesting. In the present paper, we describe mobile genetic elements in dsRNA fraction of Pinus sylvestris having witches broom abnormalities...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28408214/prevalence-and-genotypic-characterization-of-bovine-echinococcus-granulosus-isolates-by-using-cytochrome-oxidase-1-co1-gene-in-hyderabad-pakistan
#15
Muhammad Ehsan, Nasreen Akhter, Bachal Bhutto, Abdullah Arijo, Javaid Ali Gadahi
Cystic echinococcosis is an important zoonotic disease; it has serious impacts on animals as well as human health throughout the world. Genotypic characterization of Echinocossus granulosus (E. granulosus) in buffaloes has not been addressed in Pakistan. Therefore, the present study was conducted to evaluate the incidence and genotypic characterization of bovine E. granulosus. Out of 832 buffaloes examined, 112 (13.46%) were found infected. The favorable site for hydatid cyst development was liver (8.65%) followed by lungs (4...
April 4, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28407195/development-of-trap-primers-for-ricinus-communis-l
#16
K S Simões, S A Silva, E L Machado, H S Brasileiro
The objective of this article was to develop TRAP (target region amplification polymorphism) primers for castor bean, with the goal of making functional markers available for genetic studies about the species. To do this, oligonucleotides were designed based on ESTs, obtained from the NCBI (National Center for Biotechnology Information) databank, which code enzymes involved in metabolic routes of fatty acid synthesis, ricin synthesis, and resistance to castor bean pathogens. The forward primers were designed with the help of the Primer3 software and, for the reverse, six arbitrary primers were used...
April 13, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28397250/the-cage-gene-sequence-as-a-diagnostic-marker-to-identify-jp2-and-non-jp2-highly-leukotoxic-aggregatibacter-actinomycetemcomitans-serotype-b-strains
#17
A Johansson, R Claesson, C Höglund Åberg, D Haubek, J Oscarsson
BACKGROUND AND OBJECTIVE: Aggregatibacter actinomycetemcomitans is involved in oral and systemic infections, and is associated with, eg aggressive forms of periodontitis and with endocarditis. The cagE gene encodes a ≈39 kDa putative exotoxin expressed by A. actinomycetemcomitans. The level of conservation of cagE, and its possible significance in periodontal disease, has not yet been thoroughly investigated. In the present study, the role of the cagE gene as a diagnostic marker has been investigated...
April 10, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28397217/-study-of-two-chinese-families-affected-with-resistant-ovarian-syndrome-resulted-from-novel-mutations-of-fshr-gene
#18
Wen Li, Wenbin He, Lihua Zhou, Xiao Hu, Shuangfei Li, Fei Gong, Yueqiu Tan
OBJECTIVE: To explore the genetic etiology for two Chinese families affected with hypergonadotropic amenorrhea and normal number of antral follicles. METHODS: Peripheral venous blood samples were collected from the families for the extraction of genomic DNA. Mutations of FSHR and LHCGR genes were screened using PCR and Sanger sequencing. Suspected pathogenic mutations were verified in other members of the families. Bioinformatics software and NCBI were used to analyze the pathogenicity of the mutations...
April 10, 2017: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
https://www.readbyqxmd.com/read/28393016/intraspecies-comparative-genomics-of-three-strains-of-orientia-tsutsugamushi-with-different-antibiotic-sensitivity
#19
Hsiao-Mei Liao, Chien-Chung Chao, Haiyan Lei, Bingjie Li, Shien Tsai, Guo-Chiuan Hung, Wei-Mei Ching, Shyh-Ching Lo
We recently reported the genome of Orientia tsutsugamushi (OT) strain Karp (GenBank Accession #: NZ_LYMA00000000.2, https://www.ncbi.nlm.nih.gov/nuccore/NZ_LYMA00000000.2) with > 2 Mb in size through clone-based sequencing and high throughput genomic shotgun sequencing (HTS). The genomes of OT strains AFSC4 and AFSC7 were similarly sequenced by HTS Since strains AFSC4 (GenBank Accession #: NZ_LYMT00000000.1, https://www.ncbi.nlm.nih.gov/nuccore/1035784408) and AFSC7 (GenBank Accession #: NZ_LYMB00000000...
June 2017: Genomics Data
https://www.readbyqxmd.com/read/28388689/whole-genome-sequencing-of-brucella-melitensis-isolated-from-57-patients-in-germany-reveals-high-diversity-in-strains-from-middle-east
#20
Enrico Georgi, Mathias C Walter, Marie-Theres Pfalzgraf, Bernd H Northoff, Lesca M Holdt, Holger C Scholz, Lothar Zoeller, Sabine Zange, Markus H Antwerpen
Brucellosis, a worldwide common bacterial zoonotic disease, has become quite rare in Northern and Western Europe. However, since 2014 a significant increase of imported infections caused by Brucella (B.) melitensis has been noticed in Germany. Patients predominantly originated from Middle East including Turkey and Syria. These circumstances afforded an opportunity to gain insights into the population structure of Brucella strains. Brucella-isolates from 57 patients were recovered between January 2014 and June 2016 with culture confirmed brucellosis by the National Consultant Laboratory for Brucella...
2017: PloS One
keyword
keyword
10338
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"