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https://www.readbyqxmd.com/read/29353269/clinical-characteristics-and-allergen-sensitization-patterns-of-patients-with-local-allergic-rhinitis-in-southern-china
#1
Xiao Yao Tao, Chew Lip Ng, Dong Chen, Zhi Bin Lin, Shu Lian Wu, Mei Jun Liang, Chun Wei Li, Rui Xu
BACKGROUND: Local allergic rhinitis (LAR) is characterized by the production of specific IgE (sIgE) in the nasal mucosa without evidence of systemic atopy. The characteristics of LAR in Caucasians have been well documented. LAR is understudied in China, with prevalence, patient demographics, symptomatology, and the allergen sensitization profile being poorly understood. The purpose of this study is to investigate the demographics, characteristics, and allergen sensitization profile of patients with LAR in Southern China...
January 20, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29353233/cardiovascular-safety-long-term-noncardiovascular-safety-and-efficacy-of-sodium-glucose-cotransporter-2-inhibitors-in-patients-with-type-2-diabetes-mellitus-a-systemic-review-and-meta-analysis-with-trial-sequential-analysis
#2
REVIEW
Xin-Lin Zhang, Qing-Qing Zhu, Yu-Han Chen, Xue-Ling Li, Fu Chen, Jian-An Huang, Biao Xu
BACKGROUND: The cardiovascular and long-term noncardiovascular safety and efficacy of SGLT2 (sodium-glucose cotransporter 2) inhibitors have not been well documented. METHODS AND RESULTS: For cardiovascular outcomes, we performed a meta-analysis with trial sequential analysis of randomized controlled trials and adjusted observational studies, each with a minimum of 26 weeks and 2000 patient-years of follow-up. For long-term noncardiovascular safety and efficacy outcome analyses, we included only randomized controlled trials with at least 2 years and 1000 patient-years of follow-up...
January 20, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29353227/the-natural-history-of-phytosterolemia-observations-on-its-homeostasis
#3
David Mymin, Gerald Salen, Barbara Triggs-Raine, Darrel J Waggoner, Thomas Dembinski, Grant M Hatch
BACKGROUND AND AIMS: Phytosterolemia is a rare genetic disease caused by mutation of the ABCG5/8 gene. Our aim was to elucidate the natural history and homeostasis of phytosterolemia. METHODS: We analyzed a Hutterite kindred consisting of 21 homozygotes with phytosterolemia assembled over a period of two decades, all of whom carried the ABCG8 S107X mutation and were treated with ezetimibe. RESULTS: Most of these subjects were asymptomatic and devoid of clinical stigmata, and this, since they were ascertained primarily by a process of cascade testing, suggests that, relative to its true prevalence, phytosterolemia is a condition of low morbidity...
December 28, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29353103/taking-the-heat-or-taking-the-temperature-a-qualitative-study-of-a-large-scale-exercise-in-seeking-to-measure-for-improvement-not-blame
#4
Natalie Armstrong, Liz Brewster, Carolyn Tarrant, Ruth Dixon, Janet Willars, Maxine Power, Mary Dixon-Woods
Measurement of quality and safety has an important role in improving healthcare, but is susceptible to unintended consequences. One frequently made argument is that optimising the benefits from measurement requires controlling the risks of blame, but whether it is possible to do this remains unclear. We examined responses to a programme known as the NHS Safety Thermometer (NHS-ST). Measuring four common patient harms in diverse care settings with the goal of supporting local improvement, the programme explicitly eschews a role for blame...
January 2, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29352976/anterior-segment-imaging-for-angle-closure
#5
Sunee Chansangpetch, Prin Rojanapongpun, Shan C Lin
PURPOSE: To summarize the role of anterior segment imaging (AS-imaging) in angle closure diagnosis and management, and the possible advantages over the current standard of gonioscopy. DESIGN: Literature review and perspective. METHODS: Review of the pertinent publications with interpretation and perspective in relation to the use of AS-imaging in angle closure assessment focusing on anterior segment optical coherence tomography and ultrasound biomicroscopy...
January 15, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29352827/political-terrorism-and-affective-polarization-in-black-and-red-terrorists-in-italy-during-the-years-1968-1988
#6
Matteo Pacini, Icro Maremmani
Psychiatric evaluations of violent political crime were mostly performed on a case-by-case basis in a forensic environment, which made them unduly dependent on categories of presumed dangerousness and legal responsibility, rather than on a clinical definition of their mental status. In referring to such "clinical" definitions, the disorder we have in mind is not limited to the major, agitated psychotic manias or mixed states. The presence of a dominant temperament, or protracted hypomania, is enough by itself to explain an individual's engagement in a wide range of activities, not necessarily sociopathic or violent...
January 21, 2018: CNS Spectrums
https://www.readbyqxmd.com/read/29352759/regional-myocardial-function-abnormalities-are-associated-with-macro-and-microcirculation-dysfunction-in-the-metabolic-syndrome-the-resolve-study
#7
Philippe Obert, Guillaume Walther, Frédéric Dutheil, Bruno Lesourd, Robert Chapier, Daniel Courteix, Agnes Vinet
Abnormalities in myocardial and vascular function have been reported in the metabolic syndrome (MetS), but whether these alterations are related remains poorly documented. Our aim was accordingly to investigate interrelationships between macro- and microcirculatory vasoreactivity and left ventricular (LV) myocardial function in MetS patients. Eighty-eight MetS individuals and 44 age- and gender-matched healthy controls were enrolled. LV global longitudinal strain (GLS) was measured using Vector Velocity Imaging...
January 19, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29352748/use-of-e-learning-in-clinical-clerkships-effects-on-acquisition-of-dermatological-knowledge-and-learning-processes
#8
Frederike Fransen, Herm Martens, Ivo Nagtzaam, Sylvia Heeneman
Objectives: To obtain a deeper understanding of how the e-learning program, Education in Dermatology (ED), affects the acquisition of dermatological knowledge and the underlying learning processes of medical students in their clinical phase. Methods: The study used a mixed method design with a convergent parallel collection of data. Medical students (n=62) from Maastricht University (The Netherlands) were randomized to either a conventional teaching group (control group n=30) or conventional teaching plus the e-learning program (application on smartphone) group (e-learning group n=32)...
January 17, 2018: International Journal of Medical Education
https://www.readbyqxmd.com/read/29352686/interobserver-and-intraobserver-reliability-of-computed-tomography-based-three-dimensional-preoperative-planning-for-primary-total-knee-arthroplasty
#9
Michiaki Miura, Shigeo Hagiwara, Junichi Nakamura, Yasushi Wako, Yuya Kawarai, Seiji Ohtori
BACKGROUND: Preoperative planning is an important factor for total knee arthroplasty (TKA). The aim of this study is to document the interobserver and intraobserver reliability of computed tomography (CT)-based 3-dimensional (3D) preoperative planning for primary TKA. METHODS: Twenty knees (10 with osteoarthritis and 10 with rheumatoid arthritis) were studied independently by 6 orthopedic surgeons using a CT-based 3D planning system. The measurements were made twice at more than 3-week intervals without any knowledge of their own previous measurements or those of the others...
December 28, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29352649/optimal-use-of-peri-operative-human-chorionic-gonadotrophin-concentrations-to-identify-persistent-ectopic-pregnancy-after-laparoscopic-salpingostomy-a-retrospective-cohort-study
#10
Abraham N Morse, Wenyue Si, Shuang Qin, Huiying Liang
The aim of this study was to improve clinical decision-making for the identification of persistent ectopic pregnancy after linear salpingostomy. The study identified 854 laparoscopic salpingostomies performed between 2011 and 2016; 794 had a human chorionic gonadotrophin (HCG) <10 mIU/ml documented in the electronic medical record within 1 month after surgery ('successes'). Sixty (7%) received either methotrexate or repeat surgery for persistent ectopic pregnancy ('failures'). Five hundred and seventeen, including 46 'failures', had two or more immediate post-operative HCG measurements available...
December 28, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29352631/we-could-learn-much-more-from-1918-pandemic-the-mis-fortune-of-research-relying-on-original-death-certificates
#11
Wladimir J Alonso, Francielle C Nascimento, Gerardo Chowell, Cynthia Schuck-Paim
PURPOSE: The analysis of historical death certificates has enormous potential for understanding how the health of populations was shaped by diseases and epidemics and by the implementation of specific interventions. In Brazil, the systematic archiving of mortality records was initiated only in 1944-hence the analysis of death registers before this time requires searching for these documents in public archives, notaries, parishes, and especially ancient cemeteries, which are often the only remaining source of information about these deaths...
January 9, 2018: Annals of Epidemiology
https://www.readbyqxmd.com/read/29352521/microdenervation-of-the-spermatic-cord-for-post-vasectomy-pain-syndrome
#12
Wei Phin Tan, Peter N Tsambarlis, Laurence A Levine
INTRODUCTION: Post Vasectomy Pain Syndrome (PVPS) is an uncommon urologic problem that remains a challenge to manage. We aim to evaluate the outcomes of patients who underwent microdenervation of the spermatic cord (MDSC) for PVPS at our institution. METHODS: A retrospective study of all patients who underwent MDSC for PVPS by a single surgeon from March 2002 to October 2016 was performed. Pain was documented using the numerical rating scale (NRS). Spermatic cord block (SCB) was performed on all patients and success was defined as NRS ≤1 for >4 hours...
January 20, 2018: BJU International
https://www.readbyqxmd.com/read/29352516/successful-hematopoietic-cell-transplantation-following-cardiac-transplantation-in-two-pediatric-patients
#13
Rachel Phelan, Angela R Smith, Paul J Orchard, Rebecca K Ameduri
We report two patients who underwent cardiac transplantation at a young age and subsequently required a HCT for varied indications. Despite the challenges associated with HCT following cardiac transplant, including need for altered immunosuppression, toxicities related to chemotherapy exposure, and infection risks, both patients are currently alive and well. There is a paucity of such successful cases documented in the literature, and these cases highlight the critical importance of an experienced, multidisciplinary team when caring for this patient population...
January 19, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29352419/a-systematic-review-of-interventions-to-follow-up-test-results-pending-at-discharge
#14
Patrick J Darragh, T Bodley, A Orchanian-Cheff, K G Shojania, J L Kwan, P Cram
BACKGROUND: Patients are frequently discharged from the hospital before all test results have been finalized. Thirty to 40% of tests pending at discharge (TPADs) return potentially actionable results that could necessitate change in the patients' management, often unbeknownst to their physicians. Delayed follow-up of TPADs can lead to patient harm. We sought to synthesize the existing literature on interventions intended to improve the management of TPADs, including interventions designed to enhance documentation of TPADs, increase physician awareness when TPAD results finalize post-discharge, decrease adverse events related to missed TPADs, and increase physician satisfaction with TPAD management...
January 19, 2018: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/29352365/-anesthesia-problem-cards-indispensable-yet-problematic-nationwide-survey-on-experiences-from-clinical-practice
#15
M Schieren, A Böhmer, W Golbeck, J Defosse, F Wappler, H E Marcus
BACKGROUND: Anesthetic procedures may lead to severe and potentially life-threatening complications (e. g. difficult airway, allergic reactions, malignant hyperthermia). Most complications can be avoided in future anesthetic procedures with adequate preparation (e. g. awake intubation, trigger-free anesthesia). In Germany, anesthesia problem cards were introduced two decades ago to identify patients at risk and to increase patient safety by creating a standardized documentation system for anesthesia-related complications...
January 19, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29352346/the-evolution-of-breast-reduction-publications-a-bibliometric-analysis
#16
Ümran Muslu
OBJECTIVE: This study aims to make a bibliometric analysis of the studies on breast reduction (BR) between the years 1980 and 2016 and identify important studies through trend topics as well as active authors, countries, universities, scientific journals, and citation and co-citation analyses about BR. BACKGROUND: Although BR looks like one of the cosmetic surgeries performed in order to restore the woman's appearance, in fact it is a reconstructive surgery that eliminates back pain, stance disorder, headache, shoulder pain, back and cervical disk hernia, difficulty in breathing, hollowness caused by bra straps, hygiene problems under breasts (e...
January 19, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29352326/noninvasive-pulse-contour-analysis-for-determination-of-cardiac-output-in-patients-with-chronic-heart-failure
#17
Sebastian Roth, Henrik Fox, Uwe Fuchs, Uwe Schulz, Angelika Costard-Jäckle, Jan F Gummert, Dieter Horstkotte, Olaf Oldenburg, Thomas Bitter
BACKGROUND: Determination of cardiac output (CO) is essential in diagnosis and management of heart failure (HF). The gold standard to obtain CO is invasive assessment via thermodilution (TD). Noninvasive pulse contour analysis (NPCA) is supposed as a new method of CO determination. However, a validation of this method in HF is pending and performed in the present study. METHODS: Patients with chronic-stable HF and reduced left ventricular ejection fraction (LVEF ≤ 45%; HF-REF) underwent right heart catheterization including TD...
January 19, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29352278/factors-associated-with-cervical-precancerous-lesions-among-women-screened-for-cervical-cancer-in-addis-ababa-ethiopia-a-case-control-study
#18
Hirut Teame, Adamu Addissie, Wondimu Ayele, Selamawit Hirpa, Alem Gebremariam, Gdiom Gebreheat, Ahmedin Jemal
BACKGROUND: Cervical cancer is the second most prevalent cancer among women in the developing countries including Ethiopia. Precancerous lesions can be developed and risk to the development of cervical cancer over time. Early identification of the precancerous lesion and its risk factor is paramount in preventing cervical cancer. However, the determinants of cervical precancerous lesions are not well documented in Ethiopia. Therefore, this study is conducted to determine factors associated with cervical precancerous lesion among women screened for cervical cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29352261/insight-into-the-role-of-pikk-family-members-and-nf-%C3%B0%C2%BAb-in-dnadamage-induced-senescence-and-senescence-associated-secretory-phenotype-of-colon-cancer-cells
#19
Anna Strzeszewska, Olga Alster, Grażyna Mosieniak, Agata Ciolko, Ewa Sikora
Senescence of cancer cells is an important outcome of treatment of many cancer types. Cell senescence is a permanent cell cycle arrest induced by stress conditions, including DNA damage. DNA damage activates DNA damage response (DDR), which involves members of the phosphatidylinositol 3-kinase-related kinase (PIKK) superfamily: protein kinases ATM, ATR, and DNA-PKcs. The so-far collected data indicate that ATM, with its downstream targets CHK2, p53, and p21, is the key protein involved in DDR-dependent senescence...
January 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29352210/distribution-and-the-origin-of-invasive-apple-snails-pomacea-canaliculata-and-p-maculata-gastropoda-ampullariidae-in-china
#20
Qian-Qian Yang, Su-Wen Liu, Chao He, Xiao-Ping Yu
Species of Pomacea, commonly known as apple snails, are native to South America, and have become widely distributed agricultural and environmental pests in southern China since their introduction in the 1980s. However, only since 2010 have researchers recognized that at least two species, P. canaliculata and P. maculata, are present in China. Although impacts of apple snails have been extensively documented, confusion still persists regarding current distributions and origin of the species in China. To resolve this confusion, we used phylogenetic and phylogeographic methods to analyze 1464 mitochondrial COI sequences, including 349 new sequences from samples collected in southern China and 1115 publicly available sequences from snails collected in the native and introduced ranges...
January 19, 2018: Scientific Reports
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