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https://www.readbyqxmd.com/read/29779304/non-invasive-measurements-to-stratify-cardiovascular-disease-risk-in-psoriasis-patients
#1
Philippa Dickison, Jonathan J Peek, Grace Swain, Saxon D Smith
BACKGROUND AND OBJECTIVES: Psoriasis is associated with cardiovascular disease (CVD) risk factors and mortality. The aims of this study were to identify CVD risk in patients with psoriasis, and to determine their awareness of the comorbidities. METHOD: Patients with psoriasis and controls had their inter-arm blood pressure, weight, height and waist circumference measured at their routine clinic appointment. Those with psoriasis also completed a survey regarding awareness of the comorbidities...
May 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29776740/development-of-a-deformable-phantom-for-experimental-verification-of-4d-monte-carlo-simulations-in-a-deforming-anatomy
#2
Sara Gholampourkashi, Joanna E Cygler, Bernie Lavigne, Emily Heath
PURPOSE: To verify the accuracy of 4D Monte Carlo (MC) simulations, using the 4DdefDOSXYZnrc user code, in a deforming anatomy. We developed a tissue-equivalent and reproducible deformable lung phantom and evaluated 4D simulations of delivered dose to the phantom by comparing calculations against measurements. METHODS: A novel deformable phantom consisting of flexible foam, emulating lung tissue, inside a Lucite external body was constructed. A removable plug, containing an elastic tumor that can hold film and other dosimeters, was inserted in the phantom...
May 15, 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29774229/web-pages-what-can-you-see-in-a-single-fixation
#3
Ali Jahanian, Shaiyan Keshvari, Ruth Rosenholtz
Research in human vision suggests that in a single fixation, humans can extract a significant amount of information from a natural scene, e.g. the semantic category, spatial layout, and object identities. This ability is useful, for example, for quickly determining location, navigating around obstacles, detecting threats, and guiding eye movements to gather more information. In this paper, we ask a new question: What can we see at a glance at a web page - an artificial yet complex "real world" stimulus? Is it possible to notice the type of website, or where the relevant elements are, with only a glimpse? We find that observers, fixating at the center of a web page shown for only 120 milliseconds, are well above chance at classifying the page into one of ten categories...
2018: Cognitive Research: Principles and Implications
https://www.readbyqxmd.com/read/29774036/the-pattern-and-distribution-of-induced-mutations-in-j-curcas-using-reduced-representation-sequencing
#4
Fatemeh Maghuly, Stephan Pabinger, Julie Krainer, Margit Laimer
Mutagenesis in combination with Genotyping by Sequencing (GBS) is a powerful tool for introducing variation, studying gene function and identifying causal mutations underlying phenotypes of interest in crop plant genomes. About 400 million paired-end reads were obtained from 82 ethylmethane sulfonate (EMS) induced mutants and 14 wild-type accessions of Jatropha curcas for the detection of Single Nucleotide Polymorphisms (SNPs) and Insertion/Deletions (InDels) by two different approaches (nGBS and ddGBS) on an Illumina HiSeq 2000 sequencer...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29773773/cuban-epidemic-neuropathy-insights-into-the-toxic-nutritional-hypothesis-through-international-collaboration
#5
Alina González-Quevedo, Rosaralis Santiesteban-Freixas, Janis T Eells, Lucimey Lima, Alfredo A Sadun
From 1991 to 1993, an epidemic of optic and peripheral neuropathy-the largest of the century-broke out in Cuba, affecting more than 50,000 people. Initially the main clinical features were decreased visual acuity, central and cecocentral scotomas, impaired color vision and absence of the papillomacular bundle. Later, peripheral and mixed optic-peripheral forms began to appear. Due to the magnitude of the epidemic, the Cuban government requested help from the international community at the 46th World Health Assembly in 1993...
April 2018: MEDICC Review
https://www.readbyqxmd.com/read/29773528/a-digital-app-to-aid-detection-monitoring-and-management-of-dyslexia-in-young-children-dimmand-protocol-for-a-digital-health-and-education-solution
#6
Mariam R Sood, Annet Toornstra, Martin I Sereno, Mark Boland, Daniele Filaretti, Anuj Sood
BACKGROUND: Dyslexia, a specific learning difficulty and a disability as defined in the Equality Act 2010, is a lifelong condition that affects a child from the start of education. Dyslexia is characterized by difficulties in language processing (reading, spelling, and writing) which do not correspond with the child's general intellectual abilities. Although dyslexia cannot be cured, there is a consensus that interventions are more effective and have greater impact the earlier they are administered...
May 17, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29773090/vsita-an-improved-approach-of-target-amplification-in-the-identification-of-viral-pathogens
#7
Yi Zhang, Chen Zhang, Bo Li, Yang Li, Xiao Zhou He, Acher Li, Wei Wu, Su Xia Duan, Fang Zhou Qiu, Ji Wang, Xin Xin Shen, Meng Jie Yang, De Xin Li, Xue Jun Ma
OBJECTIVE: Unbiased next generation sequencing (NGS) is susceptible to interference from host or environmental sequences. Consequently, background depletion and virome enrichment techniques are usually needed for clinical samples where viral load is much lower than background sequences. METHODS: A viral Sequence Independent Targeted Amplification (VSITA) approach using a set of non-ribosomal and virus-enriched octamers (V8) was developed and compared with traditionally used random hexamers (N6)...
April 2018: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/29772404/viremia-preceding-multiple-sclerosis-two-nested-case-control-studies
#8
Emilie Hultin, Laila Sara Arroyo Mühr, Zurab Bzhalava, Maria Hortlund, Camilla Lagheden, Peter Sundström, Joakim Dillner
Infections have been suggested to be involved in Multiple Sclerosis (MS). We used metagenomic sequencing to detect both known and yet unknown microorganisms in 2 nested case control studies of MS. Two different cohorts were followed for MS using registry linkages. Serum samples taken before diagnosis as well as samples from matched control subjects were selected. In cohort1 with 75 cases and 75 controls, most viral reads were Anelloviridae-related and >95% detected among the cases. Among samples taken up to 2 years before MS diagnosis, Anellovirus species TTMV1, TTMV6 and TTV27 were significantly more common among cases...
May 14, 2018: Virology
https://www.readbyqxmd.com/read/29771965/evaluation-of-commercial-dna-and-rna-extraction-methods-for-high-throughput-sequencing-of-ffpe-samples
#9
Stine H Kresse, Heidi M Namløs, Susanne Lorenz, Jeanne-Marie Berner, Ola Myklebost, Bodil Bjerkehagen, Leonardo A Meza-Zepeda
Nucleic acid material of adequate quality is crucial for successful high-throughput sequencing (HTS) analysis. DNA and RNA isolated from archival FFPE material are frequently degraded and not readily amplifiable due to chemical damage introduced during fixation. To identify optimal nucleic acid extraction kits, DNA and RNA quantity, quality and performance in HTS applications were evaluated. DNA and RNA were isolated from five sarcoma archival FFPE blocks, using eight extraction protocols from seven kits from three different commercial vendors...
2018: PloS One
https://www.readbyqxmd.com/read/29771787/point-of-care-cryptococcal-antigen-screening-pipetting-finger-prick-blood-improves-performance-of-immuno-mycologics-lateral-flow-assay
#10
Rachel M Wake, Joseph N Jarvis, Thomas S Harrison, Nelesh P Govender
BACKGROUND: Cryptococcal antigen (CrAg) screening at point of care could improve cryptococcal meningitis prevention where laboratory resources are limited. We evaluated the accuracy of Immuno-Mycologics (IMMY, Norman, OK) CrAg lateral flow assay (LFA) using different techniques at point of care. SETTING: Two tertiary-level hospitals in Johannesburg and a community health clinic in Soweto, South Africa. METHODS: A case-control diagnostic validation study, and a prospective clinic-based implementation study using the IMMY CrAg LFA on finger-prick blood...
April 30, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29771693/use-of-patient-simulators-to-characterize-the-repeatability-and-reproducibility-of-automated-oscillometric-blood-pressure-monitors
#11
Elmiloudi M Sarhrani, Thomas B Gilmore, Andre S Lamontagne, Lauren B Harris, Jay S Kellett, Michael P Sweeney, Teresa I Navas, Oleg Vesnovsky, Charles Ho, Luke H Herbertson
OBJECTIVES: Automated oscillometric blood pressure (BP) monitors can be critical health assessment tools if they are accurate and can provide repeatable and reproducible readings. Commercial patient simulators are capable of screening for poorly performing oscillometric BP monitors. A valid screening bench test method to identify unreliable and underperforming BP monitors could advance surveillance of these devices and support regulatory decision making. METHODS: Two simulators were used to characterize a total of 19 legally marketed upper arm, wrist, hospital-grade, and public-use BP monitors...
May 16, 2018: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/29771371/allele-phasing-greatly-improves-the-phylogenetic-utility-of-ultraconserved-elements
#12
Tobias Andermann, Alexandre M Fernandes, Urban Olsson, Mats Töpel, Bernard Pfeil, Bengt Oxelman, Alexandre Aleixo, Brant C Faircloth, Alexandre Antonelli
Advances in high-throughput sequencing techniques now allow relatively easy and affordable sequencing of large portions of the genome, even for non-model organisms. Many phylogenetic studies reduce costs by focusing their sequencing efforts on a selected set of targeted loci, commonly enriched using sequence capture. The advantage of this approach is that it recovers a consistent set of loci, each with high sequencing depth, which leads to more confidence in the assembly of target sequences. High sequencing depth can also be used to identify phylogenetically informative allelic variation within sequenced individuals, but allele sequences are infrequently assembled in phylogenetic studies...
May 15, 2018: Systematic Biology
https://www.readbyqxmd.com/read/29770733/the-relationship-between-mirror-touch-synaesthesia-and-empathy-new-evidence-and-a-new-screening-tool
#13
Jamie Ward, Patricia Schnakenberg, Michael J Banissy
People with mirror-touch synaesthesia (MTS) report tactile sensations on their own body when seeing another person being touched. Although this has been associated with heightened empathy and emotion perception, this finding has been disputed. Here, we conduct two experiments to explore this relationship further. In Experiment 1, we develop a new screening measure for MTS. We show that MTS is related to vicarious experiences more generally, but is not a simple exaggerated version of normality. For example, people with MTS report videos of scratching as "touch" rather than "itchiness" and have localized sensations when watching others in pain...
May 17, 2018: Cognitive Neuropsychology
https://www.readbyqxmd.com/read/29769284/dynamic-copy-number-evolution-of-x-and-y-linked-ampliconic-genes-in-human-populations
#14
Elise A Lucotte, Laurits Skov, Jacob Malte Jensen, Moisès Coll Macià, Kasper Munch, Mikkel H Schierup
Ampliconic genes are multicopy, in majority found on sex-chromosomes and enriched for testis-expressed genes. While ampliconic genes have been associated with the emergence of hybrid incompatibilities, we know little about their copy number distribution and their turnover in human populations. Here we explore the evolution of human X- and Y-linked ampliconic genes by investigating copy number variation (CNV) and coding variation between populations using the Simons Genome Diversity Project. We develop a method to assess CNVs using the read-depth on modified X and Y chromosome targets containing only one repetition of each ampliconic gene...
May 16, 2018: Genetics
https://www.readbyqxmd.com/read/29769174/a-self-directed-mobile-intervention-waznapp-to-promote-weight-control-among-employees-at-a-lebanese-university-protocol-for-a-feasibility-pilot-randomized-controlled-trial
#15
Marco Bardus, Ghassan Hamadeh, Bouchra Hayek, Rawan Al Kherfan
BACKGROUND: Overweight and obesity have become major health problems globally with more than 1.9 billion overweight adults. In Lebanon, the prevalence of obesity and overweight is 65.4% combined. Risk factors of obesity and overweight are preventable and can be addressed by modifications in the environment and in an individual's lifestyle. Mobile technologies are increasingly used in behavioral, self-directed weight management interventions, providing users with additional opportunities to attain weight control (weight loss, weight gain prevention, etc)...
May 16, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29768992/the-effect-of-sex-and-perpetrator-victim-relationship-on-perceptions-of-domestic-homicide
#16
Linda C Karlsson, Tuulia Malén, Johanna K Kaakinen, Jan Antfolk
Previous research on how stereotypes affect perceptions of intimate partner violence and domestic homicide has found that violence committed by men is perceived as more severe and judged more harshly than violence committed by women. The present mock jury study investigated how perpetrator sex (male or female), crime type (familicide or filicide), and relatedness between perpetrator and child victims (biological or step) affect laypeople's perceptions of the appropriate consequence of the crime, the reason for the offense, responsibility of the perpetrator, the likelihood of certain background factors being present, and the risk of future violence...
May 1, 2018: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29768738/unlocking-biodiversity-and-conservation-studies-in-high-diversity-environments-using-environmental-dna-edna-a-test-with-guianese-freshwater-fishes
#17
Kévin Cilleros, Alice Valentini, Luc Allard, Tony Dejean, Roselyne Etienne, Gaël Grenouillet, Amaia Iribar, Pierre Taberlet, Régis Vigouroux, Sébastien Brosse
Determining the species compositions of local assemblages is a prerequisite to understanding how anthropogenic disturbances affect biodiversity. However, biodiversity measurements often remain incomplete due to the limited efficiency of sampling methods. This is particularly true in freshwater tropical environments that host rich fish assemblages, for which assessments are uncertain and often rely on destructive methods. Developing an efficient and non-destructive method to assess biodiversity in tropical freshwaters is highly important...
May 16, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29766396/a-novel-evaluation-of-two-related-and-two-independent-algorithms-for-eye-movement-classification-during-reading
#18
Lee Friedman, Ioannis Rigas, Evgeny Abdulin, Oleg V Komogortsev
Nystrӧm and Holmqvist have published a method for the classification of eye movements during reading (ONH) (Nyström & Holmqvist, 2010). When we applied this algorithm to our data, the results were not satisfactory, so we modified the algorithm (now the MNH) to better classify our data. The changes included: (1) reducing the amount of signal filtering, (2) excluding a new type of noise, (3) removing several adaptive thresholds and replacing them with fixed thresholds, (4) changing the way that the start and end of each saccade was determined, (5) employing a new algorithm for detecting PSOs, and (6) allowing a fixation period to either begin or end with noise...
May 15, 2018: Behavior Research Methods
https://www.readbyqxmd.com/read/29765364/rearing-water-treatment-induces-microbial-selection-influencing-the-microbiota-and-pathogen-associated-transcripts-of-cod-gadus-morhua-larvae
#19
Ragnhild I Vestrum, Kari J K Attramadal, Per Winge, Keshuai Li, Yngvar Olsen, Atle M Bones, Olav Vadstein, Ingrid Bakke
We have previously shown that K-selection and microbial stability in the rearing water increases survival and growth of Atlantic cod ( Gadus morhua ) larvae, and that recirculating aquaculture systems (RAS) are compatible with this. Here, we have assessed how water treatment influenced the larval microbiota and host responses at the gene expression level. Cod larvae were reared with two different rearing water systems: a RAS and a flow-through system (FTS). The water microbiota was examined using a 16S rDNA PCR/DGGE strategy...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29765069/de-novo-characterization-of-phenacoccus-solenopsis-transcriptome-and-analysis-of-gene-expression-profiling-during-development-and-hormone-biosynthesis
#20
Surjeet Kumar Arya, Yogeshwar Vikram Dhar, Santosh Kumar Upadhyay, Mehar Hasan Asif, Praveen Chandra Verma
The cotton mealybug Phenacoccus solenopsis is a devastating pest of cotton causing tremendous loss in the yield of crops each year. Widespread physiological and biological studies on P. solenopsis have been carried out, but the lack of genetic information has constrained our understanding of the molecular mechanisms behind its growth and development. To understand and characterize the different developmental stages, RNA-Seq platform was used to execute de-novo transcriptome assembly and differential gene expression profiling for the eggs, first, second, third instar and adult female stages...
May 15, 2018: Scientific Reports
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