Ivana Jaric, Bernhard Voelkl, Melanie Clerc, Marc W Schmid, Janja Novak, Marianna Rosso, Reto Rufener, Vanessa Tabea von Kortzfleisch, S Helene Richter, Manuela Buettner, André Bleich, Irmgard Amrein, David P Wolfer, Chadi Touma, Shinichi Sunagawa, Hanno Würbel
The phenotype of an organism results from its genotype and the influence of the environment throughout development. Even when using animals of the same genotype, independent studies may test animals of different phenotypes, resulting in poor replicability due to genotype-by-environment interactions. Thus, genetically defined strains of mice may respond differently to experimental treatments depending on their rearing environment. However, the extent of such phenotypic plasticity and its implications for the replicability of research findings have remained unknown...
October 2022: PLoS Biology