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https://www.readbyqxmd.com/read/29782255/-high-on-treatment-platelet-reactivity-determinants-on-dual-antiplatelet-therapy-in-patients-with-ischemic-heart-disease-before-elective-percutaneous-coronary-intervention
#1
E Z Golukhova, M V Grigoryan, M N Ryabinina, N I Bulaeva
OBJECTIVE: to determine impact of different laboratory and genetic factors on high on-treatment platelet reactivity (HOPR) during dual antiplatelet therapy (DAPT). METHODS: We included in this study 94 patients with stable ischemic heart disease (mean age 59±9.67 years). All patients underwent elective PCI with implantation of drug eluting stents at the background of dual antiplatelet therapy (DAPT) with aspirin and clopidogrel. Platelet reactivity was assessed using light transmission aggregometry with 5 μmol/L ADP (LTA 5ADP) and VerifyNow assay before PCI...
April 2018: Kardiologiia
https://www.readbyqxmd.com/read/29780505/macrophage-mediated-delivery-of-light-activated-nitric-oxide-prodrugs-with-spatial-temporal-and-concentration-control
#2
Michael A Evans, Po-Ju Huang, Yuji Iwamoto, Kelly N Ibsen, Emory M Chan, Yutaka Hitomi, Peter C Ford, Samir Mitragotri
Nitric oxide (NO) holds great promise as a treatment for cancer hypoxia, if its concentration and localization can be precisely controlled. Here, we report a "Trojan Horse" strategy to provide the necessary spatial, temporal, and dosage control of such drug-delivery therapies at targeted tissues. Described is a unique package consisting of (1) a manganese-nitrosyl complex, which is a photoactivated NO-releasing moiety (photoNORM), plus Nd3+ -doped upconverting nanoparticles (Nd-UCNPs) incorporated into (2) biodegradable polymer microparticles that are taken up by (3) bone-marrow derived murine macrophages...
April 21, 2018: Chemical Science
https://www.readbyqxmd.com/read/29763568/near-infrared-activatable-phthalocyanine-poly-l-glutamic-acid-conjugate-enhanced-in-vivo-safety-and-antitumor-efficacy-towards-an-effective-photodynamic-cancer-therapy
#3
Hoay Yan Cheah, Elena Gallon, Fabienne Dumoulin, See Ziau Hoe, Nina Japundžić-Žigon, Sofija Glumac, Hong Boon Lee, Prem Anand, Lip Yong Chung, Maria Jesus Vicent, Lik Voon Kiew
We previously developed a new zinc (II) phthalocyanine (ZnPc) derivative (Pc 1) conjugated to poly-L-glutamic acid (PGA) (1-PG) to address the limitations of ZnPc as part of an antitumor photodynamic therapy approach, which include hydrophobicity, phototoxicity and non-selectivity in biodistribution and tumor targeting. During this study, we discovered that 1-PG possessed high near infrared (NIR) light absorptivity (λmax = 675 nm), good singlet oxygen generation efficiency in an aqueous environment, and enhanced photocytotoxic efficacy and cancer cell uptake in vitro...
May 15, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29753881/confocal-fluorescence-imaging-to-evaluate-the-effect-of-antimicrobial-photodynamic-therapy-depth-on-p-gingivalis-and-t-denticola-biofilms
#4
Stephen Rogers, Kiyonobu Honma, Thomas S Mang
BACKGROUND: Porphyromonas gingivalis and Treponema denticola are both principally implicated in the incidence of both periodontal disease and peri-implantitis. Recent studies have demonstrated that these bacteria exhibit symbiotic growth in vitro and a synergistic virulence in co-infection of animal models. Found at varying depths throughout the biofilm, these bacteria present a significant challenge to traditional antimicrobial treatment modalities. Antimicrobial photodynamic therapy ( aPDT ) has yielded high success against bacterial biofilms, namely those found in the oral cavity...
May 10, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29752911/validation-of-the-work-disability-physical-function-assessment-battery
#5
Christine M McDonough, Pengsheng Ni, Kara Peterik, Judith D Hershberg, Lesli R Bell, Leighton Chan, Diane E Brandt, Alan M Jette
OBJECTIVE: To examine the validity of the self-report Work-Disability Functional Assessment Battery (WD-FAB) physical function scales relative to clinician ratings of function and a performance-based functional capacity evaluation: the Physical Work Performance Evaluation (PWPE). DESIGN: Cross-sectional. SETTING: Outpatient rehabilitation. PARTICIPANTS: Adults (n=50) participating in physical therapy for musculoskeletal conditions INTERVENTIONS: Not applicable...
May 9, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29750548/predictors-of-response-to-combined-wake-and-light-therapy-in-treatment-resistant-inpatients-with-depression
#6
Mette Kragh, Erik Roj Larsen, Klaus Martiny, Dorthe Norden Møller, Camilla Schultz Wihlborg, Tove Lindhardt, Poul Videbech
There is growing evidence for combined chronotherapeutic interventions as adjunctive treatments for major depression. However, as the treatments can be demanding, we need to identify predictors of response. This study aimed to describe predictors of response, remission and deterioration in the short-term phase, as well as predictors of long-term response. The predictors investigated were gender, type of depression, severity of depression, treatment resistance, quetiapine use, general self-efficacy, educational level and positive diurnal variation...
May 11, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29746095/uv-vis-imaging-of-piroxicam-supersaturation-precipitation-and-dissolution-in-a-flow-through-setup
#7
Yu Sun, Alex Chapman, Susan Weng Larsen, Henrik Jensen, Nickolaj Jacob Petersen, David M Goodall, Jesper Ostergaard
Evaluation of drug precipitation is important in order to address challenges regarding low and variable bioavail-ability of poorly water-soluble drugs, to assess potential risk of patient safety with infusion therapy and to explore injectable in situ suspension-forming drug delivery systems. Generally, drug precipitation is assessed in vitro through solution concentra-tion analysis methods. Dual-wavelength UV-Vis imaging is a novel imaging technique which may provide an opportunity for simultaneously monitoring changes in both solution and solid phases during precipitation...
May 10, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29739080/serum-free-light-chain-predict-overall-survival-and-response-to-therapy-in-patients-with-newly-diagnosed-multiple-myeloma
#8
Yanis Meddour, Momahed C Rahali, Salah E Belakehal, Fatma Z Ardjoun, Samia Chaib, Reda Djidjik
BACKGROUND: Multiple myeloma is characterized by underlying clinical and biological heterogeneity, which translates to variable responses to treatment and outcome. METHODS: To assess the roles of serum free light chain (sFLC) and K/L FLC ratio (rFLC) in the diagnoses and prognoses of multiple myeloma (MM), sFLC levels and K/L ratios were measured in 112 patients with newly diagnosed multiple myeloma using the Freelite automated immunoassay. RESULTS: Abnormal sFLC and/or rFLC levels were detected 99...
April 1, 2018: Clinical Laboratory
https://www.readbyqxmd.com/read/29731626/the-influence-of-disease-severity-and-lifestyle-factors-on-the-peak-annual-25-oh-d-value-of-copd-patients
#9
Magnus Kentson, Per Leanderson, Petra Jacobson, Hans Lennart Persson
Background: The prevalence of individuals deficient in vitamin D (defined as a serum level of the stable metabolite 25(OH)D <50 nmol/L) is increasing in countries with low annual ultraviolet (UV) radiation and among individuals unable to perform outdoor activities, for example, COPD patients. Objective: To assess the role of vitamin D deficiency, independently of seasonal variation, the peak annual value of 25(OH)D was measured in subjects with advanced COPD ± long-term oxygen therapy (LTOT) and lung healthy control subjects...
2018: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/29725945/low-level-laser-irradiation-modifies-the-effect-of-hyperglycemia-on-adhesion-molecule-levels
#10
Krzysztof Góralczyk, Justyna Szymańska, Łukasz Gryko, Jacek Fisz, Danuta Rość
Endothelium plays a key role in maintaining vascular homeostasis by secreting active factors involved in many biological processes such as hemostasis, angiogenesis, and inflammation. Hyperglycemia in diabetic patients causes dysfunction of endothelial cells. Soluble fractions of adhesion molecules like sE-selectin and vascular cell adhesion molecule (sVCAM) are considered as markers of endothelial damage. The low-level laser therapy (LLLT) effectively supports the conventional treatment of vascular complications in diabetes, for example hard-to-heal wounds in patients with diabetic foot syndrome...
May 3, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29724012/frondoside-a-enhances-the-anti-cancer-effects-of-oxaliplatin-and-5-fluorouracil-on-colon-cancer-cells
#11
Samir Attoub, Kholoud Arafat, Tamam Khalaf, Shahrazad Sulaiman, Rabah Iratni
Over recent years, we have demonstrated that Frondoside A, a triterpenoid glycoside isolated from an Atlantic sea cucumber, has potent in vitro and in vivo anti-cancer effects against human pancreatic, breast, and lung cancer. We have also demonstrated that Frondoside A is able to potentiate and/or synergize the anti-cancer effects of major classical cytotoxic agents, namely, gemcitabine, paclitaxel, and cisplatin, in the treatment of pancreatic, breast, and lung cancer, respectively. This study evaluates the impact of Frondoside A alone and in combination with the standard cytotoxic drugs oxaliplatin and 5-fluorouracil (5-FU) in the treatment of colon cancer using three human colon cancer cell lines, namely, HT-29, HCT-116, and HCT8/S11...
May 1, 2018: Nutrients
https://www.readbyqxmd.com/read/29722183/near-infrared-low-level-laser-therapy-and-cell-proliferation-the-emerging-role-of-redox-sensitive-signal-transduction-pathways
#12
REVIEW
Mario Migliario, Maurizio Sabbatini, Carmen Mortellaro, Filippo Renò
Lasers devices are widely used in various medical fields (e.g. surgery, dermatology, dentistry, rehabilitative medicine, etc) for different applications, ranging from surgical ablation of tissues to biostimulation and pain relief. Laser is an electromagnetic radiation which effects on biological tissues strongly depends on a number of physical parameters. Laser wavelength, energy output, irradiation time and modality, temperature and tissue penetration properties have to be set up according to the clinical target tissue and the desired effect...
May 2, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29703163/development-of-a-computational-promoter-with-highly-efficient-expression-in-tumors
#13
Shu-Yi Ho, Bo-Hau Chang, Chen-Han Chung, Yu-Ling Lin, Cheng-Hsun Chuang, Pei-Jung Hsieh, Wei-Chih Huang, Nu-Man Tsai, Sheng-Chieh Huang, Yen-Ku Liu, Yu-Chih Lo, Kuang-Wen Liao
BACKGROUND: Gene therapy is a potent method to increase the therapeutic efficacy against cancer. However, a gene that is specifically expressed in the tumor area has not been identified. In addition, nonspecific expression of therapeutic genes in normal tissues may cause side effects that can harm the patients' health. Certain promoters have been reported to drive therapeutic gene expression specifically in cancer cells; however, low expression levels of the target gene are a problem for providing good therapeutic efficacy...
April 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29689080/beyond-syndromic-management-opportunities-for-diagnosis-based-treatment-of-sexually-transmitted-infections-in-low-and-middle-income-countries
#14
Nigel J Garrett, Farzana Osman, Bhavna Maharaj, Nivashnee Naicker, Andrew Gibbs, Emily Norman, Natasha Samsunder, Hope Ngobese, Nireshni Mitchev, Ravesh Singh, Salim S Abdool Karim, Ayesha B M Kharsany, Koleka Mlisana, Anne Rompalo, Adrian Mindel
INTRODUCTION: In light of the limited impact the syndromic management approach has had on the global sexually transmitted infection (STI) epidemic, we assessed a care model comprising point-of-care (POC) STI testing, immediate treatment, and expedited partner therapy (EPT) among a cohort of young women at high HIV risk in South Africa. METHODS AND FINDINGS: HIV negative women presenting for STI care underwent POC testing for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV), and swabs were sent for NG culture and susceptibility testing...
2018: PloS One
https://www.readbyqxmd.com/read/29686821/acute-effect-of-different-concentrations-of-cayenne-pepper-cataplasm-on-sensory-motor-functions-and-serum-levels-of-inflammation-related-biomarkers-in-healthy-subjects
#15
Nejc Sarabon, Stefan Löfler, Jan Cvecka, Wolfgang Hübl, Sandra Zampieri
Physical medicine therapies are often used in treating widespread musculoskeletal disorders, such as neck and low back pain. Herbal cataplasms containing rubefacient substances, such as Cayenne pepper, or galenic preparations like Munari cataplasm are commonly used as natural medications to treat painful areas. In this paper we show the effects of a 20-min application of Cayenne pepper and kaolin powder cataplasm (CPC) on healthy subjects. Treatment effects were evaluated by cold/hot feeling on visual analogue scale, blood pressure, body temperature, skin light touch sensations, two-point discrimination, and pain threshold to a mechanical stimulus, before and immediately after, 15 min after and 30 min after different concentration of Cayenne pepper in CPC preparation on healthy subjects...
January 12, 2018: European Journal of Translational Myology
https://www.readbyqxmd.com/read/29680675/far-red-light-mediated-programmable-anti-cancer-gene-delivery-in-cooperation-with-photodynamic-therapy
#16
Jinhui Wang, Hua He, Xin Xu, Xiao Wang, Yongbing Chen, Lichen Yin
Effective anti-cancer therapy is hurdled by the complicated extracellular and intracellular barriers, and thus a smart gene vector that can enable programmable gene delivery is highly demanded. Photo-manipulation of gene delivery processes features spatial and temporal precision, while majority of current strategies utilizes short-wavelength UV/visible light with poor tissue penetration or high-power-density near-infrared (NIR) light that would cause undesired heat damage. Herein, an ROS-degradable polycation was designed and co-delivered with a photosensitizer (PS), thus realizing photo-programmable gene delivery using far-red light (661 nm) at low optical power density (down to 5 mW cm-2 )...
April 12, 2018: Biomaterials
https://www.readbyqxmd.com/read/29667293/enhanced-in-vitro-biocompatibility-and-water-dispersibility-of-magnetite-and-cobalt-ferrite-nanoparticles-employed-as-ros-formation-enhancer-in-radiation-cancer-therapy
#17
Stefanie Klein, Melek Kızaloğlu, Luis Portilla, Hyoungwon Park, Tobias Rejek, Julian Hümmer, Karsten Meyer, Rainer Hock, Luitpold V R Distel, Marcus Halik, Carola Kryschi
Efficient magnetic reactive oxygen species (ROS) formation enhancing agents after X-ray treatment are realized by functionalizing superparamagnetic magnetite (Fe3 O4 ) and Co-ferrite (CoFe2 O4 ) nanoparticles with self-assembled monolayers (SAMs). The Fe3 O4 and CoFe2 O4 nanoparticles are synthesized using Massart's coprecipitation technique. Successful surface modification with the SAM forming compounds 1-methyl-3-(dodecylphosphonic acid) imidazolium bromide, or (2-{2-[2-hydroxy-ethoxy]-ethoxy}-ethyl phosphonic acid provides biocompatibility and long-term stability of the Fe3 O4 and CoFe2 O4 nanoparticles in cell media...
April 18, 2018: Small
https://www.readbyqxmd.com/read/29665018/differential-response-of-human-dermal-fibroblast-subpopulations-to-visible-and-near-infrared-light-potential-of-photobiomodulation-for-addressing-cutaneous-conditions
#18
Charles Mignon, Natallia E Uzunbajakava, Irene Castellano-Pellicena, Natalia V Botchkareva, Desmond J Tobin
BACKGROUND OBJECTIVES: The past decade has witnessed a rapid expansion of photobiomodulation (PBM), demonstrating encouraging results for the treatment of cutaneous disorders. Confidence in this approach, however, is impaired not only by a lack of understanding of the light-triggered molecular cascades but also by the significant inconsistency in published experimental outcomes, design of the studies and applied optical parameters. This study aimed at characterizing the response of human dermal fibroblast subpopulations to visible and near-infrared (NIR) light in an attempt to identify the optical treatment parameters with high potential to address deficits in aging skin and non-healing chronic wounds...
April 17, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29656218/improved-hypocrellin-a-production-in-shiraia-bambusicola-by-light-dark-shift
#19
Chun Xiao Sun, Yan Jun Ma, Jian Wen Wang
Hypocrellin A (HA) is a major bioactive perylenequinone from the fruiting body of Shiraia bambusicola used for the treatment of skin diseases and developed as a photodynamic therapy (PDT) agent against cancers and viruses. The mycelial culture of S. bambusicola under dark is a biotechnological alternative for HA production but with low yield. In this study, light and dark conditions were investigated to develop effective elicitation on HA production in the cultures. Our results showed the constant light at 200 lx stimulated HA production without any growth retardation of mycelia...
April 9, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29642437/photodynamic-effect-of-methylene-blue-and-low-level-laser-radiation-in-head-and-neck-squamous-cell-carcinoma-cell-lines
#20
Barbara Kofler, Angela Romani, Christian Pritz, Teresa Bernadette Steinbichler, Volker Hans Schartinger, Herbert Riechelmann, Jozsef Dudas
Photodynamic therapy (PDT) is suggested to have an impact on the treatment of early stage head and neck cancers (HNSCC). We investigated the effect of PDT with methylene blue (MB) and a diode laser (660 nm) as the laser source on HNSCC cell lines as an in vitro model of surface oral squamous cell carcinoma. Cell-cultures were exposed to 160 µM MB for 4 min and to laser light for 8 min. Viability was proven via cell viability assay and clonogenic survival via clone counting assay. The combination of MB and diode laser evidenced high efficient loss of cell viability by 5% of the control, while treatment with the same concentration of MB for 4 min alone showed a viability of 46% of the control...
April 7, 2018: International Journal of Molecular Sciences
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