keyword
MENU ▼
Read by QxMD icon Read
search

Difficult

keyword
https://www.readbyqxmd.com/read/29793135/accuracy-of-magnetic-resonance-venography-in-diagnosing-cerebral-venous-sinus-thrombosis
#1
Liansheng Gao, Weilin Xu, Tao Li, Xiaobo Yu, Shenglong Cao, Hangzhe Xu, Feng Yan, Gao Chen
OBJECTIVES: The non-specific clinical manifestations and lack of effective diagnostic techniques have made cerebral venous sinus thrombosis (CVST) difficult to recognize and easy to misdiagnose. Several studies have suggested that different types of magnetic resonance venography (MRV) have advantages in diagnosing CVST. We conducted this meta-analysis to assess the accuracy of MRV in identifying CVST. MATERIAL AND METHODS: We searched the Embase, PubMed, and Chinese Biomedical (CBM) databases comprehensively to retrieve eligible articles up to Mar 31, 2018...
May 17, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29793116/patterns-of-invasive-growth-in-malignant-gliomas-the-hippocampus-emerges-as-an-invasion-spared-brain-region
#2
Awais A Mughal, Lili Zhang, Artem Fayzullin, Andres Server, Yuping Li, Yingxi Wu, Rainer Glass, Torstein Meling, Iver A Langmoen, Trygve B Leergaard, Einar O Vik-Mo
BACKGROUND: Widespread infiltration of tumor cells into surrounding brain parenchyma is a hallmark of malignant gliomas, but little data exist on the overall invasion pattern of tumor cells throughout the brain. METHODS: We have studied the invasive phenotype of malignant gliomas in two invasive mouse models and patients. Tumor invasion patterns were characterized in a patient-derived xenograft mouse model using brain-wide histological analysis and magnetic resonance (MR) imaging...
May 21, 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29793099/carbon-monoxide-analysis-method-in-human-blood-by-airtight-gas-syringe-gas-chromatography-mass-spectrometry-ags-gc-ms-relevance-for-postmortem-poisoning-diagnosis
#3
S Oliverio, V Varlet
Carbon monoxide is one of the most abundant toxic air pollutants. Symptoms of a CO intoxication are non-specific, leading to a high number of misdiagnosed CO poisoning cases that are missing in the disease statistics. The chemical nature of the molecule makes it difficult to detect for long periods and at low levels, thus requiring a very accurate and sensitive method. Current methods capable of accurate and sensitive analyses are available, however an inconsistency between results and symptoms are frequently reported...
May 18, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29793042/aminergic-neuromodulation-of-associative-visual-learning-in-harnessed-honey-bees
#4
Nino Mancini, Martin Giurfa, Jean-Christophe Sandoz, Aurore Avarguès-Weber
The honey bee Apis mellifera is a major insect model for studying visual cognition. Free-flying honey bees learn to associate different visual cues with a sucrose reward and may deploy sophisticated cognitive strategies to this end. Yet, the neural bases of these capacities cannot be studied in flying insects. Conversely, immobilized bees are accessible to neurobiological investigation but training them to respond appetitively to visual stimuli paired with sucrose reward is difficult. Here we succeeded in coupling visual conditioning in harnessed bees with pharmacological analyses on the role of octopamine (OA), dopamine (DA) and serotonin (5-HT) in visual learning...
May 21, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29793015/right-atrial-anomalous-muscle-bundle-presenting-with-acute-superior-vena-cava-syndrome-and-pulmonary-embolism-surgical-management
#5
Jeko M Madjarov, Michael G Katz, Sophia Madjarova, Svetozar Madzharov, Frank R Arko, David W Miller, Francis Robicsek
BACKGROUND: An anomalous muscle bundle crossing the right atrial cavity represents a pathological finding with unproved clinical significance. This congenital anomaly may be difficult to recognize via echocardiography and could be confused with other intra-cavitary lesions. METHODS: We report a case of a 53-year-old female presented to the cardio-vascular service with acute superior vena cava syndrome and sub-massive pulmonary embolism. RESULTS: The patient underwent venography confirming superior vena cava stenosis...
May 21, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29792966/one-step-fabrication-of-chitosan-fe-oh-3-beads-for-efficient-adsorption-of-anionic-dyes
#6
XinxinYang, Yumei Li, Hongmei Gao, Chuying Wang, Xiaohuan Zhang, Hongli Zhou
In this study, we reported the one-step synthesis of chitosan-Fe(OH)3 beads without the use of acid solvent, which could be used as effective adsorbents for anionic dyes removal. The preparation process was easy and green. The as-prepared beads were characterized for structural and morphological analysis in detail using several techniques, such as Scanning Electron Microscope, Fourier Transform Infrared Spectroscopy, X-Ray Diffraction, X-ray photoelectron spectroscopy and Thermogravimetric analysis. The content of Fe(OH)3 in chitosan-Fe(OH)3 beads was 54...
May 21, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29792944/enrichment-of-low-density-symbiont-dna-from-minute-insects
#7
Corinne M Stouthamer, Suzanne Kelly, Martha S Hunter
Symbioses between bacteria and insects are often associated with changes in important biological traits that can significantly affect host fitness. To a large extent, studies of these interactions have been based on physiological changes or induced phenotypes in the host, and the genetic mechanisms by which symbionts interact with their hosts have only recently become better understood. Learning about symbionts has been challenging in part due to difficulties such as obtaining enough high quality genomic material for high throughput sequencing technology, especially for symbionts present in low titers, and in small or difficult to rear non-model hosts...
May 21, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29792936/efficient-detection-of-copy-number-mutations-in-pms2-exons-with-close-homologs-detection-of-copy-number-variants-in-3-pms2-exons
#8
Daniel S Herman, Christina Smith, Chang Liu, Cecily P Vaughn, Selvi Palaniappan, Colin C Pritchard, Brian H Shirts
Detection of 3' PMS2 copy number mutations that cause Lynch syndrome is difficult, because of highly homologous pseudogenes. To improve the accuracy and efficiency of clinical screening for these mutations, we developed a new method to analyze standard capture-based, next-generation sequencing data to identify deletions and duplications in PMS2 exons 9 to 15. The approach captures sequence reads using PMS2 targets, maps sequences randomly amongst regions with equal mapping quality, counts reads aligned to homologous exons and introns, and flags read count ratios outside of empirically derived reference ranges...
May 21, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29792890/the-visual-cortex-and-visual-cognition-in-huntington-s-disease-an-overview-of-current-literature
#9
REVIEW
Emma M Coppen, Jeroen van der Grond, Ellen P Hart, Egbert A J F Lakke, Raymund A C Roos
The processing of visual stimuli from retina to higher cortical areas has been extensively studied in the human brain. In Huntington's disease (HD), an inherited neurodegenerative disorder, it is suggested that visual processing deficits are present in addition to more characteristic signs such as motor disturbances, cognitive dysfunction, and behavioral changes. Visual deficits are clinically important because they influence overall cognitive performance and have implications for daily functioning. The aim of this review is to summarize current literature on clinical visual deficits, visual cognitive impairment, and underlying visual cortical changes in HD patients...
May 21, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29792828/recurrence-of-pericardial-mesothelioma-affecting-the-myocardium-after-pericardial-resection
#10
María Rodríguez, Hari R Mallidi, Annacarolina da Silva, Raphael Bueno
Primary pericardial mesothelioma represents less than 1% of all malignant mesotheliomas1 . These tumors are very rare, difficult to diagnose and with poor response to stablished treatments. Common clinical presentations include constrictive symptoms, cardiac tamponade and cardiac failure. Surgery can be curative in early stages and localized tumors and pericardiectomy and chemotherapy are often used as palliative approaches. Herein we present a case of a 54 years old female who has so far survived 4 years after a primary resection of a pericardial mesothelioma, and was referred with myocardial and aorto- pulmonary window recurrences for further treatment...
May 21, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29792771/is-blogging-a-new-form-of-communication-in-palliative-health-care-a-qualitative-research-study
#11
Anneli Ozanne, Ingela Henoch, Susann Strang
AIM: To illuminate experiences of living with life-threatening diseases as described in blogs and the experience of blogging about these matters. METHODS: A secondary analysis of 21 blogs was performed. RESULTS: It was difficult for bloggers to accept what they perceived to be the unacceptable aspects of having an life-threatening disease. They searched for hope and acceptance, and tried to manage their life. They felt strengthened by supportive encounters with health professionals, relatives, friends, and from their blogging...
May 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29792720/-experimental-processing-of-corrosion-casts-of-large-animal-organs
#12
R Pálek, V Liška, L Eberlová, H Mírka, M Svoboda, S Haviar, M Emingr, O Brzoň, P Mik, V Třeška
INTRODUCTION: Corrosion casts (CCs) are used for the visualization and assessment of hollow structures. CCs with filled capillaries enable (with the help of imaging methods) to obtain data for mathematical organ perfusion modelling. As the processing is more difficult in case of organs with greater volume of the vasculature, mainly organs from small animals have been cast up to now. The aim of this study was to optimize the protocol of corrosion casting of different organs of pig. Porcine organs are relatively easily accessible and frequently used in experimental medicine...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29792532/the-moderating-influence-of-disorder-on-coached-overreporting-using-the-mmpi-2-rf
#13
Ariane M Olsen, Carlo O C Veltri
Overreporting has always been a concern within psychological evaluations. The Minnesota Multiphasic Personality Inventory-2-Restructured Form (Ben-Porath & Tellegen, 2008/2011 ) contains validity scales designed for detecting noncredible responses. In this study, 270 undergraduates were instructed to feign either schizophrenia, posttraumatic stress disorder (PTSD) or generalized anxiety disorder (GAD); some participants were coached on symptoms and validity scales. Results at both the individual protocol and mean validity scale score levels suggest that each feigned disorder moderates the effectiveness of coaching on validity scale detection...
May 24, 2018: Journal of Personality Assessment
https://www.readbyqxmd.com/read/29792452/foundations-of-teamwork-and-collaboration
#14
James E Driskell, Eduardo Salas, Tripp Driskell
The term teamwork has graced countless motivational posters and office walls. However, although teamwork is often easy to observe, it is somewhat more difficult to describe and yet more difficult to produce. At a broad level, teamwork is the process through which team members collaborate to achieve task goals. Teamwork refers to the activities through which team inputs translate into team outputs such as team effectiveness and satisfaction. In this article, we describe foundational research underlying current research on teamwork...
May 2018: American Psychologist
https://www.readbyqxmd.com/read/29792442/the-case-against-specialized-visual-spatial-short-term-memory
#15
Candice C Morey
The dominant paradigm for understanding working memory, or the combination of the perceptual, attentional, and mnemonic processes needed for thinking, subdivides short-term memory (STM) according to whether memoranda are encoded in aural-verbal or visual formats. This traditional dissociation has been supported by examples of neuropsychological patients who seem to selectively lack STM for either aural-verbal, visual, or spatial memoranda, and by experimental research using dual-task methods. Though this evidence is the foundation of assumptions of modular STM systems, the case it makes for a specialized visual STM system is surprisingly weak...
May 24, 2018: Psychological Bulletin
https://www.readbyqxmd.com/read/29792307/putative-vaccine-candidates-and-drug-targets-identified-by-reverse-vaccinology-and-subtractive-genomics-approaches-to-control-haemophilus-ducreyi-the-causative-agent-of-chancroid
#16
Alissa de Sarom, Arun Kumar Jaiswal, Sandeep Tiwari, Letícia de Castro Oliveira, Debmalya Barh, Vasco Azevedo, Carlo Jose Oliveira, Siomar de Castro Soares
Chancroid is a sexually transmitted infection (STI) caused by the Gram-negative bacterium Haemophilus ducreyi The control of chancroid is difficult and the only current available treatment is antibiotic therapy; however, antibiotic resistance has been reported in endemic areas. Owing to recent outbreaks of STIs worldwide, it is important to keep searching for new treatment strategies and preventive measures. Here, we applied reverse vaccinology and subtractive genomic approaches for the in silico prediction of potential vaccine and drug targets against 28 strains of H...
May 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29792225/correction-to-lifetime-stress-accelerates-epigenetic-aging-in-an-urban-african-american-cohort-relevance-of-glucocorticoid-signaling
#17
Anthony S Zannas, Janine Arloth, Tania Carrillo-Roa, Stella Iurato, Simone Röh, Kerry J Ressler, Charles B Nemeroff, Alicia K Smith, Bekh Bradley, Christine Heim, Andreas Menke, Jennifer F Lange, Tanja Brückl, Marcus Ising, Naomi R Wray, Angelika Erhardt, Elisabeth B Binder, Divya Mehta
Upon publication of the original article [1] it was highlighted by the authors that a transposition error affected Additional file 1, causing the misplacement of several columns and rendering the table difficult to read. This transposition does not influence any of the results nor analyses presented in the paper and has since been formally noted in this correction article; the corrected file is available here as an Additional File. The publisher apologizes for this error.
May 23, 2018: Genome Biology
https://www.readbyqxmd.com/read/29792224/health-technology-assessment-of-public-health-interventions-an-analysis-of-characteristics-and-comparison-of-methods-study-protocol
#18
Tim Mathes, Gerald Willms, Stephanie Polus, Constance Stegbauer, Melanie Messer, Corinna Klingler, Heidi Ehrenreich, Dea Niebuhr, Georg Marckmann, Ansgar Gerhardus, Dawid Pieper
BACKGROUND: Conducting a health technology assessment (HTA) of public health interventions (PHIs) poses some challenges. PHIs are often complex interventions, which affect the number and degree of interactions of the aspects to be assessed. Randomized controlled trials on PHIs are rare as they are difficult to conduct because of ethical or feasibility issues. The aim of this study is to provide an overview of the methodological characteristics and to compare the applied assessment methods in HTAs on PHIs...
May 23, 2018: Systematic Reviews
https://www.readbyqxmd.com/read/29792172/oral-health-and-orofacial-pain-in-people-with-dementia-admitted-to-acute-hospital-wards-observational-cohort-study
#19
Liza J M van de Rijt, Roxane A F Weijenberg, Alexandra R Feast, Victoria Vickerstaff, Frank Lobbezoo, Elizabeth L Sampson
BACKGROUND: Orofacial pain in people with dementia is difficult to detect, and often under-treated. Our aim was to investigate the prevalence of orofacial pain in people with dementia in acute hospitals in the UK. Secondary aims were to examine oral health status and explore associations between orofacial pain and oral health factors. METHODS: This cross-sectional observational study was carried out in two UK hospitals. Using the Orofacial Pain Scale in Non-Verbal Individuals (OPS-NVI) to identify orofacial pain, 101 participants with dementia, admitted to acute medical wards, were observed for at least 3 min during rest and chewing...
May 23, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29792139/process-intensification-techniques-for-the-production-of-nano-and-submicronic-particles-for-food-and-medical-applications
#20
Marco Stoller, Luca Di Palma, Srikanth Vuppala, Nicola Verdone, Giorgio Vilardi
BACKGROUND: Nowadays, nanoparticles are of great interest for the industry due to their numerous possible applications in several fields. Research on this topic seeks to develop many procedures to produce nanoparticles, mostly at lab scale, batch-wise and with low yield. These procedures generally do not suit industrial needs of continuous, high capacity production. Moreover, the product characteristics require targeting narrow particle size distributions and high quality, which is difficult to achieve by traditional equipment...
May 23, 2018: Current Pharmaceutical Design
keyword
keyword
103358
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"