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https://www.readbyqxmd.com/read/28231682/unmet-needs-of-the-patients-with-obsessive-compulsive-disorder
#1
(no author information available yet)
BACKGROUND: Obsessive compulsive disorder (OCD) is a disabling mental disorder with the chronic and difficult course. The disorder is accompanied by numerous limitations in personal and interpersonal functioning. OCD decreases the quality of life and the chance to maintain relationships and professional status. The patients with OCD often experience a severe disabling course of the disorder. Even the individuals, who follow treatment advice, are often still highly symptomatic. In the last decade, the concept of the needs has been assessed as an extent of the traditional outcome evaluation in order to focus on the identification of the specific needs of the patients and their relatives, improve the patients´ overall mental condition and quality of life, and also to increase the treatment effectiveness of the mental disorders...
October 24, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28231642/meniscal-transplants-and-scaffolds-a-systematic-review-of-the-literature
#2
REVIEW
Sean Dangelmajer, Filippo Familiari, Roberto Simonetta, Mehmet Kaymakoglu, Gazi Huri
The reported incidence of meniscal tears is approximately 61 per 100,000. In instances where preservation of the native meniscus is no longer a feasible option, meniscal allograft transplantation (MAT) and implants or scaffolds may be considered. The goal of this review was to compare the success and failure rates of two techniques, MAT and meniscal scaffolds, and make an inference which treatment is more preferable at the present time and future. Studies that met inclusion criteria were assessed for technique used, type of transplant used, number of procedures included in the study, mean age of patients, mean follow-up time, number of failures, failure rate, and reported reoperation rate...
March 1, 2017: Knee Surgery & related Research
https://www.readbyqxmd.com/read/28231613/genetic-determinism-vs-phenotypic-plasticity-in-protist-morphology
#3
Matthieu Mulot, Katarzyna Marcisz, Lara Grandgirard, Enrique Lara, Anush Kosakyan, Bjorn J M Robroek, Mariusz Lamentowicz, Richard J Payne, Edward A D Mitchell
Untangling the relationships between morphology and phylogeny is key to building a reliable taxonomy, but is especially challenging for protists, where the existence of cryptic or pseudocryptic species makes finding relevant discriminant traits difficult. Here we use Hyalosphenia papilio (a testate amoeba) as a model species to investigate the contribution of phylogeny and phenotypic plasticity in its morphology. We study the response of Hyalosphenia papilio morphology (shape and pores number) to environmental variables in 1) a manipulative experiment with controlled conditions (water level), 2) an observational study of a withinsite natural ecological gradient (water level), and 3) an observational study across 37 European peatlands (climate)...
February 23, 2017: Journal of Eukaryotic Microbiology
https://www.readbyqxmd.com/read/28231605/endonasal-versus-external-dacryocystorhinostomy-for-nasolacrimal-duct-obstruction
#4
REVIEW
Lona Jawaheer, Caroline J MacEwen, Deepa Anijeet
BACKGROUND: A dacryocystorhinostomy (DCR) procedure aims to restore drainage of tears by bypassing a blockage in the nasolacrimal duct, through the creation of a bony ostium that allows communication between the lacrimal sac and the nasal cavity. It can be performed using endonasal or external approaches. The comparative success rates of these two approaches have not yet been established and this review aims to evaluate the relevant up-to-date research. OBJECTIVES: The primary aim of this review is to compare the success rates of endonasal DCR with that of external DCR...
February 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28231570/analysis-of-a-surgical-treatment-for-persistent-urorectal-fistulas-after-radical-cancer-surgery-a-comparison-of-prostate-cancer-and-rectal-cancer
#5
Yasuyuki Sakai, Yoshinobu Komai, Norio Saito, Masaaki Ito, Minoru Sakuraba
INTRODUCTION: The study aimed to present our experience of surgical treatment for urorectal fistulas (URF) that develop after cancer surgery. MATERIALS AND METHODS: Fourteen patients with URF who were treated at our institution from 2005 through 2015 were retrospectively analyzed. Among these, 7 patients had previous surgical treatment of prostate cancer (PC) and the other 7 had been treated for rectal cancer (RC). The fistula was resected through a perineal incision, and the urinary and fecal defects were separately closed with the hinge flap method followed by interposition of a muscle flap transfer...
February 24, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/28231567/innate-lung-defense-during-invasive-aspergillosis-new-mechanisms
#6
Jaleesa M Garth, Chad Steele
Invasive aspergillosis (IA) is one of the most difficult to treat and, consequently, one of the most lethal fungal infections known to man. Continued use of immunosuppressive agents during chemotherapy and organ transplantation often leads to the development of neutropenia, the primary risk factor for IA. However, IA is also becoming more appreciated in chronic diseases associated with corticosteroid therapy. The innate immune response to Aspergillus fumigatus, the primary agent in IA, plays a pivotal role in the recognition and elimination of organisms from the pulmonary system...
February 24, 2017: Journal of Innate Immunity
https://www.readbyqxmd.com/read/28231418/exploring-human-papillomavirus-vaccination-refusal-among-ethnic-minorities-in-england-a-comparative-qualitative-study
#7
Alice S Forster, Lauren Rockliffe, Laura A V Marlow, Helen Bedford, Emily McBride, Jo Waller
OBJECTIVES: In England, uptake of human papillomavirus (HPV) vaccination to prevent HPV-related cancer is lower among girls from ethnic minority backgrounds. We aimed to explore the factors that prevented ethnic minority parents from vaccinating, compared to White British non-vaccinating parents and vaccinating ethnic minority parents. METHODS: Interviews with 33 parents (n = 14 ethnic minority non-vaccinating, n = 10 White British non-vaccinating, n = 9 ethnic minority vaccinating) explored parents' reasons for giving or withholding consent for HPV vaccination...
February 23, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28231390/intraoperative-assessment-of-laryngeal-pathologies-with-optical-coherence-tomography-integrated-into-a-surgical-microscope
#8
Anna S Englhard, Tom Betz, Veronika Volgger, Eva Lankenau, Georg J Ledderose, Herbert Stepp, Christian Homann, Christian S Betz
OBJECTIVE: Endoscopic examination followed by tissue biopsy is the gold standard in the evaluation of lesions of the upper aerodigestive tract. However, it can be difficult to distinguish between healthy mucosa, dysplasia, and invasive carcinoma. Optical coherence tomography (OCT) is a non-invasive technique which acquires high-resolution, cross-sectional images of tissue in vivo. Integrated into a surgical microscope, it allows the intraoperative evaluation of lesions simultaneously with microscopic visualization...
February 23, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28231374/mechanical-venous-anastomosis-in-head-and-neck-microvascular-reconstruction-as-an-equivalent-to-the-gold-standard
#9
Eric Thorpe, Yash Patil
To define the most successful and efficient manner to perform venous microvascular anastomoses, the effectiveness of mechanical venous anastomosis in head and neck microvascular reconstruction is reviewed. Head and neck reconstruction with free flap techniques has become the norm and gold standard for large defects. This retrospective, multicenter case series of a single microvascular surgeon's experience with mechanical venous anastomoses specifically assessed the effectiveness of head and neck reconstruction and the complications associated with it...
February 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28231373/auricular-complications-in-parotid-temporal-bone-infratemporal-fossa-and-lateral-skull-base-surgery
#10
Patrick S Carpenter, Ryan C Burgette, John P Leonetti, Sam J Marzo
Neoplasms located in the parotid region, temporal bone, infratemporal fossa, and lateral skull base represent a challenge due to their difficult anatomic location and surrounding neurovascular structures. A variety of surgical approaches are appropriate to access this area, although several of them can place the auricular blood supply in danger. If the auricular blood supply is compromised, ischemia and, eventually, avascular necrosis of the auricle can occur. Auricular necrosis often can cause patients a delay in adjuvant radiation therapy and result in the need for additional reconstructive procedures...
February 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28231251/empirical-lessons-regarding-contraception-in-a-protracted-refugee-setting-a-descriptive-study-from-maela-camp-on-the-thai-myanmar-border-1996-2015
#11
Somjet Srikanok, Daniel M Parker, Amber L Parker, Tracey Lee, Aung Myat Min, Pranee Ontuwong, Saw Oo Tan, Supachai Sirinonthachai, Rose McGready
Conflict settings and refugee camps can be chaotic places, with large and rapid population movements, exacerbated public health problems, and ad hoc health services. Reproductive health care that includes family planning is of heightened importance in such settings, however, funding and resources tend to be constrained and geared towards acute health services such as trauma management and infectious disease containment. Here we report on the complexities and challenges of providing family planning in a post-emergency refugee setting, using the example of the largest refugee camp on the Thai-Myanmar border, in existence now for over 30 years...
2017: PloS One
https://www.readbyqxmd.com/read/28231244/unexpectedly-high-leprosy-seroprevalence-detected-using-a-random-surveillance-strategy-in-midwestern-brazil-a-comparison-of-elisa-and-a-rapid-diagnostic-test
#12
Marco Andrey C Frade, Natália A de Paula, Ciro M Gomes, Sebastian Vernal, Fred Bernardes Filho, Helena B Lugão, Marilda M M de Abreu, Patrícia Botini, Malcolm S Duthie, John S Spencer, Rosa Castália F R Soares, Norma T Foss
BACKGROUND: Leprosy diagnosis is mainly based on clinical evaluation, although this approach is difficult, especially for untrained physicians. We conducted a temporary campaign to detect previously unknown leprosy cases in midwestern Brazil and to compare the performance of different serological tests. METHODS: A mobile clinic was stationed at the main bus terminal in Brasília, Brazil. Volunteers were quizzed and given a clinical exam to allow categorization as either patients, known contacts of patients or non-contacts, and blood was collected to determine anti-PGL-I and anti-LID-1 antibody titers by ELISA and by the NDO-LID rapid test...
February 23, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28231003/utilization-of-gastrointestinal-simulator-gis-an-in-vivo-predictive-dissolution-methodology-coupled-with-computational-approach-to-forecast-oral-absorption-of-dipyridamole
#13
Kazuki Matsui, Yasuhiro Tsume, Susumu Takeuchi, Amanda Searls, Gordon L Amidon
Weakly basic drugs exhibit a pH-dependent dissolution profile in the gastrointestinal (GI) tract, making it difficult to predict their oral absorption profile. The aim of this study was to investigate the utility of the Gastrointestinal Simulator (GIS), a novel in vivo predictive dissolution (iPD) methodology, in predicting the in vivo behavior of the weakly basic drug, dipyridamole, when coupled with in silico analysis. The GIS is a multi-compartmental dissolution apparatus, which represents physiological gastric emptying in the fasted state...
February 23, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28230930/in-silico-design-of-optimal-dissolution-kinetics-of-fe-doped-zno-nanoparticles-results-in-cancer-specific-toxicity-in-a-preclinical-rodent-model
#14
Bella B Manshian, Suman Pokhrel, Uwe Himmelreich, Kaido Tämm, Lauri Sikk, Alberto Fernández, Robert Rallo, Tarmo Tamm, Lutz Mädler, Stefaan J Soenen
Cancer cells have unique but widely varying characteristics that have proven them difficult to be treated by classical therapeutics and calls for novel and selective treatment options. Nanomaterials (NMs) have been shown to display biological effects as a function of their chemical composition, and the extent and exact nature of these effects can vary between different biological environments. Here, ZnO NMs are doped with increasing levels of Fe, which allows to finely tune their dissolution rate resulting in significant differences in their biological behavior on cancer or normal cells...
February 23, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28230806/metabolic-profiling-and-identification-of-shikonins-in-root-periderm-of-two-invasive-echium-spp-weeds-in-australia
#15
Dominik Skoneczny, Paul A Weston, Xiaocheng Zhu, Geoff M Gurr, Ragan M Callaway, Russel A Barrow, Leslie A Weston
Metabolic profiling can be successfully implemented to analyse a living system's response to environmental conditions by providing critical information on an organism's physiological state at a particular point in time and allowing for both quantitative and qualitative assessment of a specific subset(s) of key metabolites. Shikonins are highly reactive chemicals that affect various cell signalling pathways and possess antifungal, antibacterial and allelopathic activity. Based on previous bioassay results, bioactive shikonins, are likely to play important roles in the regulation of rhizosphere interactions with neighbouring plants, microbes and herbivores...
February 21, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28230767/an-adaptive-multi-sensor-data-fusion-method-based-on-deep-convolutional-neural-networks-for-fault-diagnosis-of-planetary-gearbox
#16
Luyang Jing, Taiyong Wang, Ming Zhao, Peng Wang
A fault diagnosis approach based on multi-sensor data fusion is a promising tool to deal with complicated damage detection problems of mechanical systems. Nevertheless, this approach suffers from two challenges, which are (1) the feature extraction from various types of sensory data and (2) the selection of a suitable fusion level. It is usually difficult to choose an optimal feature or fusion level for a specific fault diagnosis task, and extensive domain expertise and human labor are also highly required during these selections...
February 21, 2017: Sensors
https://www.readbyqxmd.com/read/28230663/mastery-in-bariatric-surgery-the-long-term-surgeon-learning-curve-of-roux-en-y-gastric-bypass
#17
Aristithes G Doumouras, Fady Saleh, Sama Anvari, Scott Gmora, Mehran Anvari, Dennis Hong
OBJECTIVE: To determine the effect of cumulative volume on all-cause morbidity and operative time. BACKGROUND: Gastric bypass is an important public health procedure, but it is difficult to master with little data about how surgeon cumulative volume affects outcomes longitudinally. METHODS: This was a longitudinal study of 29 surgeons during the first 6 years of performing bariatric surgery in a high-volume, regionalized center of excellence system...
February 22, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28230613/osteoid-osteoma-of-the-acetabulum-diagnosis-and-medical-treatment
#18
Nikolaos A Laliotis, Antonia S Bindoudi, Ioannis A Tsitouridis, Iordanis G Petrakis, John M Kirkos
We describe the medical management of an acetabular osteoid osteoma in an 11-year-old girl. There was a 2-year delay until proper diagnosis of the patient's pathology was made. Accurate localization of the nidus in the subchondral bone, involving the cartilage, is difficult on the basis of plain radiographs. All imaging methods, including computed tomography, MRI, and bone scintigraphy, were used to confirm the diagnosis. We proposed medical treatment to avoid possible severe complications from surgical intervention...
February 22, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28230569/procedure-oriented-torsional-anatomy-of-the-hand-for-spasticity-injection
#19
Joslyn John, John Cianca, Faye Chiou-Tan, Sindhu Pandit, Erin Furr-Stimming, Katherine H Taber
OBJECTIVES: To provide musculoskeletal ultrasound (MSKUS) images of hand anatomy in the position of hemiparetic flexion as a reference for spasticity injections. After a stroke, spasticity can result in anatomic distortion of the hand. Spasticity may require treatment with botulinum toxin or phenol injections. Anatomic distortion may decrease the accuracy of injections. Standard anatomic references are of limited utility because they are not in this spastic hemiparetic position. There presently is no anatomic reference in the literature for these spastic postures...
February 23, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28230457/comparative-effectiveness-of-rapid-acting-insulins-in-adults-with-diabetes
#20
Patrick N Racsa, Yunus Meah, Jeffrey J Ellis, Kimberly R Saverno
BACKGROUND: Although there are a variety of insulin products and new delivery modalities available, the absence of direct clinical and economic comparisons can make treatment planning and formulary decision making difficult. Direct comparisons between insulin aspart and insulin lispro from a large heterogeneous population are not available. OBJECTIVE: To assess differences in clinical outcomes, medication adherence, utilization, and total health care costs between aspart and lispro and vial versus pen modalities for administering these short-acting insulin analogs...
March 2017: Journal of Managed Care & Specialty Pharmacy
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