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https://www.readbyqxmd.com/read/27905614/methanobactins-from-genome-to-function
#1
Laura M K Dassama, Grace E Kenney, Amy C Rosenzweig
Methanobactins (Mbns) are ribosomally produced, post-translationally modified peptide (RiPP) natural products that bind copper with high affinity using nitrogen-containing heterocycles and thioamide groups. In some methanotrophic bacteria, Mbns are secreted under conditions of copper starvation and then re-internalized as a copper source for the enzyme particulate methane monooxygenase (pMMO). Genome mining studies have led to the identification and classification of operons encoding the Mbn precursor peptide (MbnA) as well as a number of putative transport, regulatory, and biosynthetic proteins...
December 1, 2016: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/27869143/genome-mining-unveils-widespread-natural-product-biosynthetic-capacity-in-human-oral-microbe-streptococcus-mutans
#2
Liwei Liu, Tingting Hao, Zhoujie Xie, Geoff P Horsman, Yihua Chen
Streptococcus mutans is a major pathogen causing human dental caries. As a Gram-positive bacterium with a small genome (about 2 Mb) it is considered a poor source of natural products. Due to a recent explosion in genomic data available for S. mutans strains, we were motivated to explore the natural product production potential of this organism. Bioinformatic characterization of 169 publically available genomes of S. mutans from human dental caries revealed a surprisingly rich source of natural product biosynthetic gene clusters...
November 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27827899/relationship-between-added-sugars-consumption-and-chronic-disease-risk-factors-current-understanding
#3
REVIEW
James M Rippe, Theodore J Angelopoulos
Added sugars are a controversial and hotly debated topic. Consumption of added sugars has been implicated in increased risk of a variety of chronic diseases including obesity, cardiovascular disease, diabetes and non-alcoholic fatty liver disease (NAFLD) as well as cognitive decline and even some cancers. Support for these putative associations has been challenged, however, on a variety of fronts. The purpose of the current review is to summarize high impact evidence including systematic reviews, meta-analyses, and randomized controlled trials (RCTs), in an attempt to provide an overview of current evidence related to added sugars and health considerations...
November 4, 2016: Nutrients
https://www.readbyqxmd.com/read/27810731/surface-micro-morphology-phase-transformation-and-mechanical-reliability-of-ground-and-aged-monolithic-zirconia-ceramic
#4
L F Guilardi, G K R Pereira, A Gündel, M P Rippe, L F Valandro
This study aimed to determine the effects of grinding and low temperature aging on the biaxial flexural strength, structural reliability (Weibull analysis), surface topography, roughness analysis, and phase transformation (t→m) of an yttrium-stabilized tetragonal zirconia polycrystalline ceramic. Ceramic discs (15.0×1.2±0.2mm, VITA In-Ceram YZ) were prepared and randomly assigned into six groups according to 2 factors (n=30): 'grinding' (Ctrl - without treatment, as-sintered; Xfine - grinding with extra fine diamond bur - 30µm; Coarse - grinding by coarse diamond bur - 151µm), and 'aging' (without or with aging: Ctrl(LTD); Xfine(LTD); Coarse(LTD))...
October 24, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27800552/lasso-peptide-biosynthetic-protein-larb1-binds-both-leader-and-core-peptide-regions-of-the-precursor-protein-lara
#5
Wai Ling Cheung, Maria Y Chen, Mikhail O Maksimov, A James Link
Lasso peptides are a member of the superclass of ribosomally synthesized and posttranslationally modified peptides (RiPPs). Like all RiPPs, lasso peptides are derived from a gene-encoded precursor protein. The biosynthesis of lasso peptides requires two enzymatic activities: proteolytic cleavage between the leader peptide and the core peptide in the precursor protein, accomplished by the B enzymes, and ATP-dependent isopeptide bond formation, accomplished by the C enzymes. In a subset of lasso peptide biosynthetic gene clusters from Gram-positive organisms, the B enzyme is split between two proteins...
October 26, 2016: ACS Central Science
https://www.readbyqxmd.com/read/27795312/an-aminotransferase-is-responsible-for-the-deamination-of-the-n-terminal-leucine-and-required-for-formation-of-oxazolone-ring-a-in-methanobactin-of-methylosinus-trichosporium-ob3b
#6
Wenyu Gu, Bipin S Baral, Alan A DiSpirito, Jeremy D Semrau
: Gene expression in methanotrophs has been shown to be affected by the availability of a variety of metals, most notably copper regulating expression of alternative forms of methane monooxygenase. A copper-binding compound or chalkophore called methanobactin plays a key role in copper uptake in methanotrophs. Methanobactin is a ribosomally synthesized and post-translationally modified peptide (RiPP) with two heterocyclic rings with an associated thioamide for each ring, formed from X-Cys dipeptide sequences that bind copper...
October 21, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27777674/the-effect-of-burnout-on-medical-errors-and-professionalism-in-first-year-internal-medicine-residents
#7
Jason Kwah, Jennifer Weintraub, Robert Fallar, Jonathan Ripp
BACKGROUND : Burnout is a common issue in internal medicine residents, and its impact on medical errors and professionalism is an important subject of investigation. OBJECTIVE : To evaluate differences in medical errors and professionalism in internal medicine residents with and without burnout. METHODS : A single institution observational cohort study was conducted between June 2011 and July 2012. Burnout was measured using the Maslach Burnout Inventory to generate subscores for the following 3 domains: emotional exhaustion, depersonalization, and sense of personal accomplishment...
October 2016: Journal of Graduate Medical Education
https://www.readbyqxmd.com/read/27777075/influences-on-the-frequency-and-type-of-community-pharmacy-services
#8
William R Doucette, Julia J Rippe, Caroline A Gaither, David H Kreling, David A Mott, Jon C Schommer
OBJECTIVES: To describe services provided by community pharmacies and to identify factors associated with services being provided in community pharmacies. DESIGN: Cross-sectional national mail survey. SETTING AND PARTICIPANTS: Pharmacists actively practicing in community pharmacies (independent, chain, mass merchandisers, and supermarkets). OUTCOME MEASURES: Frequency and type of pharmacy services available in a community pharmacy, including medication therapy management, immunization, adjusting medication therapy, medication reconciliation, disease state management, health screening or coaching, complex nonsterile compounding, and point-of-care testing...
October 21, 2016: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/27754146/os-28-04-distal-renal-denervation
#9
Stanislav Pekarskiy, Andrei Baev, Viktor Mordovin, Galina Semke, Tatiana Ripp, Alla Falkovskaya, Ekaterina Sitkova, Valeria Lichikaki, Irina Zubanova, Maria Kuzmichkina, Sergei Popov
OBJECTIVE: A failure of endovascular renal denervation (RDN) as a series of point treatments equally distributed within main trunk of renal artery (Symplicity and other methods) was easily predictable. It may only be effective if all renal nerves closely follow the course of renal artery (RA) from aorta to the kidney. However, surgical studies demonstrated that proximally most renal nerves go at a distance from RA and join mainly its distal part. To evaluate whether denervation treatment in distal part of RA is more effective than conventional RDN...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27753884/ish-ada-05-the-new-technology-and-classification-for-the-arteries-reactivity-in-patients-with-hypertension
#10
Tatiana Ripp, Victor Mordobin, Evgeny Ripp, Galina Semke, Alla Falkovskaya, Ludmila Fedorova, Sergey Popov
OBJECTIVE: The aim of the study was to develop the new technology and to classify changes of arterial reactivity (AR) after metabolic stress tests in patients with hypertension. DESIGN AND METHOD: All participants of research have given the informed agreement. We used new special portative apparatus with metering rate during hypercapnia (inhalation 2 min 4% mixture of carbonic gas with air (gipercapnia) or hyperoxia - 100% oxygen (giperoxia) and in periods of recovery (rec) (air-inhalation 2 min) of 264 patients (age 52...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27752134/the-b1-protein-guides-the-biosynthesis-of-a-lasso-peptide
#11
Shaozhou Zhu, Christopher D Fage, Julian D Hegemann, Andreas Mielcarek, Dushan Yan, Uwe Linne, Mohamed A Marahiel
Lasso peptides are a class of ribosomally synthesized and post-translationally modified peptides (RiPPs) with a unique lariat knot-like fold that endows them with extraordinary stability and biologically relevant activity. However, the biosynthetic mechanism of these fascinating molecules remains largely speculative. Generally, two enzymes (B for processing and C for cyclization) are required to assemble the unusual knot-like structure. Several subsets of lasso peptide gene clusters feature a "split" B protein on separate open reading frames (B1 and B2), suggesting distinct functions for the B protein in lasso peptide biosynthesis...
October 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27734249/microproteinuria-predicts-organ-failure-in-patients-presenting-with-acute-pancreatitis
#12
Sara Bertilsson, Per Swärd, Anders Håkansson, Rafid Tofik, Bengt Rippe, Evangelos Kalaitzakis
BACKGROUND AND AIMS: The disease course of acute pancreatitis (AP) ranges from mild and self-limiting to severe inflammation, associated with significant morbidity and mortality. At present, there are no universally accepted and reliable predictors for severity. Microproteinuria has been associated with the presence of systemic inflammatory response syndrome as well as trauma, although its association with AP is not well understood. The aim of this study was to investigate the value of microproteinuria to predict development of organ failure in AP...
December 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27729870/criticality-maximizes-complexity-in-neural-tissue
#13
Nicholas M Timme, Najja J Marshall, Nicholas Bennett, Monica Ripp, Edward Lautzenhiser, John M Beggs
The analysis of neural systems leverages tools from many different fields. Drawing on techniques from the study of critical phenomena in statistical mechanics, several studies have reported signatures of criticality in neural systems, including power-law distributions, shape collapses, and optimized quantities under tuning. Independently, neural complexity-an information theoretic measure-has been introduced in an effort to quantify the strength of correlations across multiple scales in a neural system. This measure represents an important tool in complex systems research because it allows for the quantification of the complexity of a neural system...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27725304/quantification-of-telomere-features-in-tumor-tissue-sections-by-an-automated-3d-imaging-based-workflow
#14
Manuel Gunkel, Inn Chung, Stefan Wörz, Katharina I Deeg, Ronald Simon, Guido Sauter, David T W Jones, Andrey Korshunov, Karl Rohr, Holger Erfle, Karsten Rippe
The microscopic analysis of telomere features provides a wealth of information on the mechanism by which tumor cells maintain their unlimited proliferative potential. Accordingly, the analysis of telomeres in tissue sections of patient tumor samples can be exploited to obtain diagnostic information and to define tumor subgroups. In many instances, however, analysis of the image data is conducted by manual inspection of 2D images at relatively low resolution for only a small part of the sample. As the telomere feature signal distribution is frequently heterogeneous, this approach is prone to a biased selection of the information present in the image and lacks subcellular details...
October 7, 2016: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/27698135/genomic-charting-of-ribosomally-synthesized-natural-product-chemical-space-facilitates-targeted-mining
#15
Michael A Skinnider, Chad W Johnston, Robyn E Edgar, Chris A Dejong, Nishanth J Merwin, Philip N Rees, Nathan A Magarvey
Microbial natural products are an evolved resource of bioactive small molecules, which form the foundation of many modern therapeutic regimes. Ribosomally synthesized and posttranslationally modified peptides (RiPPs) represent a class of natural products which have attracted extensive interest for their diverse chemical structures and potent biological activities. Genome sequencing has revealed that the vast majority of genetically encoded natural products remain unknown. Many bioinformatic resources have therefore been developed to predict the chemical structures of natural products, particularly nonribosomal peptides and polyketides, from sequence data...
October 3, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27681559/nitric-oxide-synthase-inhibition-causes-acute-increases-in-glomerular-permeability-in-vivo-dependent-upon-reactive-oxygen-species-ros
#16
Julia Dolinina, Kristinn Sverrisson, Anna Rippe, Carl M Öberg, Bengt Rippe
There is increasing evidence that the permeability of the glomerular filtration barrier (GFB) is partly regulated by a balance between the bioavailability of nitric oxide (NO) and that of reactive oxygen species (ROS). It has been postulated that normal or moderately elevated NO levels protect the GFB from permeability increases, while ROS, through reducing the bioavailability of NO, have the opposite effect. We tested the tentative antagonism between NO and ROS on glomerular permeability in anaesthetized Wistar rats, in which the left ureter was cannulated for urine collection, while simultaneously blood access was achieved...
September 28, 2016: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/27662231/the-glycocins-in-a-class-of-their-own
#17
Gillian E Norris, Mark L Patchett
First reported in 2011, glycocins (glycosylated bacteriocins) are bacterial toxins that constitute a subset of ribosomally synthesised and post-translationally modified peptide (RiPP) natural products. Three NMR structures (glycocin F, ASM1 and sublancin 168), two with helix-loop-helix Cs α/α folds, are deposited in the PDB. Each structure contains a monosaccharide β-S-linked to a cysteine side chain. Three more glycocins (thurandacin, and enterocins F4-9 and 96) have been biochemically characterised, and others predicted on the basis of bioinformatic analyses...
September 21, 2016: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/27650042/deciphering-bioactive-peptides-and-their-action-mechanisms-through-proteomics
#18
Osmel Fleitas Martinez, Caleb Mawuli Agbale, Fernanda Nomiyama, Octávio Luiz Franco
Bioactive peptides such as antimicrobial peptides (AMPs), ribosomally synthesized and post translationally modified peptides (RiPPs) and the non-ribosomal peptides (NRPs) have emerged with promising applications in medicine, agriculture and industry. However, their development has been limited by several difficulties making it necessary to search for novel discovery methods. In this context, proteomics has been considered a reliable tool. Areas covered: This review highlights recent developments in proteomic tools that facilitate the discovery of AMPs, RiPPs and NRPs as well as the elucidation of action mechanisms of AMPs and resistance mechanisms of pathogens to them...
October 8, 2016: Expert Review of Proteomics
https://www.readbyqxmd.com/read/27643207/ish-ada-05-the-new-technology-and-classification-for-the-arteries-reactivity-in-patients-with-hypertension
#19
Tatiana Ripp, Victor Mordobin, Evgeny Ripp, Galina Semke, Alla Falkovskaya, Ludmila Fedorova, Sergey Popov
OBJECTIVE: The aim of the study was to develop the new technology and to classify changes of arterial reactivity (AR) after metabolic stress tests in patients with hypertension. DESIGN AND METHOD: All participants of research have given the informed agreement. We used new special portative apparatus with metering rate during hypercapnia (inhalation 2 min 4% mixture of carbonic gas with air (gipercapnia) or hyperoxia - 100% oxygen (giperoxia) and in periods of recovery (rec) (air-inhalation 2 min) of 264 patients (age 52...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643076/os-28-04-distal-renal-denervation
#20
Stanislav Pekarskiy, Andrei Baev, Viktor Mordovin, Galina Semke, Tatiana Ripp, Alla Falkovskaya, Ekaterina Sitkova, Valeria Lichikaki, Irina Zubanova, Maria Kuzmichkina, Sergei Popov
OBJECTIVE: A failure of endovascular renal denervation (RDN) as a series of point treatments equally distributed within main trunk of renal artery (Symplicity and other methods) was easily predictable. It may only be effective if all renal nerves closely follow the course of renal artery (RA) from aorta to the kidney. However, surgical studies demonstrated that proximally most renal nerves go at a distance from RA and join mainly its distal part. To evaluate whether denervation treatment in distal part of RA is more effective than conventional RDN...
September 2016: Journal of Hypertension
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