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https://www.readbyqxmd.com/read/28281108/recognizing-cadasil-a-secondary-cause-of-migraine-with-aura
#1
REVIEW
John Glenn Burkett, Carrie Dougherty
PURPOSE OF REVIEW: CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an important disease to consider in the differential diagnosis of migraine with aura. This review examines current literature regarding migraine in CADASIL, as well as diagnostic and treatment modalities. RECENT FINDINGS: Recent studies have shown that smoking is a modifiable risk factor for progression of CADASIL (Chabriat et al. in Stroke 47:4-11, 2015)...
April 2017: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/28130501/endovascular-flow-diversion-for-treatment-of-anterior-communicating-artery-region-cerebral-aneurysms-a-single-center-cohort-of-50-cases
#2
Geoffrey P Colby, Matthew T Bender, Li-Mei Lin, Narlin Beaty, Judy Huang, Rafael Tamargo, Alexander Coon
BACKGROUND: Flow diversion represents a novel but definitive treatment for recurrent and difficult-to-coil aneurysms of the anterior communicating artery (ACoA) region, of which reports are limited. OBJECTIVE: To determine the effectiveness of the Pipeline embolization device (PED) in treating aneurysms in the ACoA region. METHODS: We retrospectively reviewed an IRB-approved database of patients with an aneurysm at a single institution for patients with ACoA or A1-A2 aneurysms treated with PED...
January 27, 2017: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/28114647/clinical-characteristics-risk-factors-and-outcomes-associated-with-neonatal-hemorrhagic-stroke-a-population-based-case-control-study
#3
Lauran Cole, Deborah Dewey, Nicole Letourneau, Bonnie J Kaplan, Kathleen Chaput, Clare Gallagher, Jacquie Hodge, Amalia Floer, Adam Kirton
Importance: Hemorrhage into the brain of term newborns often results in major injury and lifelong disability. The clinical epidemiology of neonatal hemorrhagic stroke (NHS) remains undefined, hindering the development of strategies to improve outcomes. Objective: To characterize the incidence, types, presentations, associated factors, and outcomes of neonatal hemorrhagic stroke. Design, Setting, and Participants: Population-based, nested case-control study...
March 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/27688267/vessel-perforation-during-stent-retriever-thrombectomy-for-acute-ischemic-stroke-technical-details-and-clinical-outcomes
#4
Maxim Mokin, Kyle M Fargen, Christopher T Primiani, Zeguang Ren, Travis M Dumont, Leonardo B C Brasiliense, Guilherme Dabus, Italo Linfante, Peter Kan, Visish M Srinivasan, Mandy J Binning, Rishi Gupta, Aquilla S Turk, Lucas Elijovich, Adam Arthur, Hussain Shallwani, Elad I Levy, Adnan H Siddiqui
BACKGROUND: Vessel perforation during stent retriever thrombectomy is a rare complication; typically only single instances have been reported. OBJECTIVE: To report on a series of patients whose stent retriever thrombectomy was complicated by intraprocedural vessel perforation and discuss its potential mechanisms, rescue treatment strategies, and clinical significance. METHODS: Cases with intraprocedural vessel perforation, where a stent retriever was used either as a primary treatment approach or as a part of a direct aspiration first pass technique (ADAPT), were included in the final analysis...
September 29, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27416778/falls-risk-post-stroke-examining-contributions-from-paretic-versus-non-paretic-limbs-to-unexpected-forward-gait-slips
#5
Tejal Kajrolkar, Tanvi Bhatt
Community-dwelling stroke survivors show a high incidence of falls with unexpected external perturbations during dynamic activities like walking. Previous evidence has demonstrated the importance of compensatory stepping to restore dynamic stability in response to perturbations in hemiparetic stroke survivors. However, these studies were limited to either stance perturbations or perturbation induced under the unaffected limb. This study aimed to compare the differences, if any, between the non-paretic and paretic sides in dynamic stability and protective stepping strategies when exposed to unexpected external perturbation during walking...
September 6, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27062528/a-retrospective-analysis-of-triptan-and-dhe-use-for-basilar-and-hemiplegic-migraine
#6
Paul G Mathew, Regina Krel, Bhuvin Buddhdev, Hossein Ansari, Shivang G Joshi, Warren D Spinner, Brad C Klein
BACKGROUND: Patients with basilar migraine (BM) and hemiplegic migraine (HM) have been excluded from triptan and DHE clinical trials due to a potential risk of ischemic vascular events, and the FDA mandates that package labeling state that they are contraindicated in BM and HM. The objective of this study was to demonstrate that triptans and DHE can be used for the abortive treatment of BM and HM without significant adverse ischemic vascular events. METHODS: A retrospective chart review of patients with BM features or HM who received acute abortive treatment with either triptans or DHE was conducted at 4 headache centers to assess the frequency of ischemic vascular events after administration...
April 8, 2016: Headache
https://www.readbyqxmd.com/read/27022600/an-analytic-approach-for-describing-and-prioritizing-health-inequalities-at-the-local-level-in-canada-a-descriptive-study
#7
Cory Neudorf, Daniel Fuller, Jennifer Cushon, Riley Glew, Hollie Turner, Cristina Ugolini
BACKGROUND: We present the health inequalities analytic approach used by the Saskatoon Health Region to examine health equity. Our aim was to develop a method that will enable health regions to prioritize action on health inequalities. METHODS: Data from admissions to hospital, physician billing, reportable diseases, vital statistics and childhood immunizations in the city of Saskatoon were analyzed for the years ranging from 1995 to 2011. Data were aggregated to the dissemination area level...
October 2015: CMAJ Open
https://www.readbyqxmd.com/read/26996929/outcome-incidence-and-risk-factors-for-stroke-after-pediatric-heart-transplantation-an-analysis-of-the-international-society-for-heart-and-lung-transplantation-registry
#8
Conall T Morgan, Cedric Manlhiot, Brian W McCrindle, Anne I Dipchand
BACKGROUND: In the registry of the International Society for Heart and Lung Transplantation (ISHLT), cerebrovascular accidents are the fifth most common cause for mortality after pediatric heart transplantation (PHTx), but details are lacking in the literature. The purpose of this analysis of the ISHLT registry was to determine the prevalence, risk factors and outcomes of stroke after PHTx. METHODS: Data from the ISHLT registry (1998 to 2010) were used to identify all patients whose primary transplantation was performed at <18 years of age...
May 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/26901914/ten-years-experience-of-pregnancy-outcomes-in-women-with-cardiac-valvulopathies-are-valve-prostheses-worst
#9
André Viveiros Monteiro, Joana Rebelo, Lino Patricio, Ana Campos, Augusta Borges, Rui Cruz Ferreira
BACKGROUND AND AIM OF THE STUDY: The population of pregnant women with valvular heart disease (VHD), and in particular with valvular heart prostheses (VHPs), represents a unique patient group where data are scarce, and where there is an increased risk for adverse maternal and obstetric events. The study aim was to assess the experience of a tertiary center with regards to cardiac and pregnancy outcomes in women with VHD, comparing VHPs with other VHD pathologies. METHODS: A retrospective analysis of 84 pregnancies in women with VHD (mean age 27...
May 2015: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/26879878/headache-and-facial-pain-in-sickle-cell-disease
#10
REVIEW
Angeliki Vgontzas, Larry Charleston, Matthew S Robbins
Children and adolescents with sickle cell disease (SCD) have a high prevalence of recurrent headaches (24.0-43.9 %). Acute presentation with headache can be diagnostically challenging, as the clinician must consider evaluation of several potentially devastating conditions including vascular diseases (stroke, hemorrhage, venous sinus thrombosis, moyamoya, posterior reversible encephalopathy syndrome), facial and orbital bone infarcts, dental pain, and osteomyelitis. Patients with SCD and primary headache disorders may benefit from comprehensive headache treatment plans that include abortive therapy, prophylactic therapy, and non-pharmacological modalities...
March 2016: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/26861024/subclavian-steal-endovascular-treatment-of-total-occlusions-of-the-subclavian-artery-using-a-retrograde-transradial-subintimal-approach
#11
Sudhakar R Satti, Sohil N Golwala, Ansar Z Vance, Sonya N Tuerff
INTRODUCTION: In symptomatic subclavian steal syndrome, endovascular treatment is the first line of therapy prior to extra-anatomic surgical bypass procedures. Subintimal recanalization has been well described in the literature for the coronary arteries, and more recently, in the lower extremities. By modifying this approach, we present a unique retrograde technique using a heavy tip microwire to perform controlled subintimal dissection. METHODS: We present two cases of symptomatic subclavian steal related to chronic total occlusion of the left subclavian artery and right innominate artery, respectively...
June 2016: Interventional Neuroradiology
https://www.readbyqxmd.com/read/26649204/valvular-excrescences-a-possible-transient-phenomenon
#12
Peter Marstrand, Maiken Brit Jensen, Nikolaj Ihlemann
The thrombogenic potential of Lambl excrescences (LE) is minimal unlike the benign tumour fibroelastoma wherefrom thrombi often originate. We present a patient with multiple strokes within a six-year period. A possible locus on the aortic valve was found and diagnosed as fibroelastoma. Before aortic valve substitution prior finding could not be visualized and surgery was aborted. Due to review of earlier Transesophageal Echocardiography (TEE) and the transient component, LE was accepted as the most plausible diagnosis...
2015: Case Reports in Cardiology
https://www.readbyqxmd.com/read/26556440/prolonged-qt-interval-in-st-elevation-myocardial-infarction-predictors-and-prognostic-value-in-medium-term-follow-up
#13
Alessandro Galluzzo, Cristina Gallo, Alberto Battaglia, Simone Frea, Federico G Canavosio, Michela Botta, Serena Bergerone, Fiorenzo Gaita
AIMS: The prognostic role of corrected QT interval in ST-elevation myocardial infarction is still unknown. This study aims to identify the prognostic value of corrected QT interval prolongation (≥480 ms) in acute coronary syndrome. METHODS: One hundred and eighty-five consecutive patients with ST-elevation myocardial infarction were prospectively enrolled and electrocardiographic monitoring of corrected QT interval was performed during the hospitalization. RESULTS: Over a mean period of 17...
June 2016: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/26475142/prognostic-importance-of-changes-in-cardiac-structure-and-function-in-heart-failure-with-preserved-ejection-fraction-and-the-impact-of-spironolactone
#14
RANDOMIZED CONTROLLED TRIAL
Amil M Shah, Brian Claggett, Nancy K Sweitzer, Sanjiv J Shah, Anita Deswal, Inder S Anand, Jerome L Fleg, Bertram Pitt, Marc A Pfeffer, Scott D Solomon
BACKGROUND: Limited data exist regarding the impact of aldosterone antagonist therapy on cardiac structure and function in heart failure with preserved ejection fraction and on the prognostic relevance of changes in cardiac structure and function in heart failure with preserved ejection fraction. METHODS AND RESULTS: Cardiac structure and function were assessed by quantitative echocardiography at baseline and at 12- to 18-month follow-up in 239 patients with heart failure with preserved ejection fraction (left ventricular [LV] ejection fraction [LVEF] ≥45%) enrolled in the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial...
November 2015: Circulation. Heart Failure
https://www.readbyqxmd.com/read/26378452/comprehensive-serology-based-on-a-peptide-elisa-to-assess-the-prevalence-of-closely-related-equine-herpesviruses-in-zoo-and-wild-animals
#15
Azza Abdelgawad, Robert Hermes, Armando Damiani, Benjamin Lamglait, Gábor Á Czirják, Marion East, Ortwin Aschenborn, Christian Wenker, Samy Kasem, Nikolaus Osterrieder, Alex D Greenwood
Equine herpesvirus type 1 (EHV-1) causes respiratory disorders and abortion in equids while EHV-1 regularly causes equine herpesvirus myeloencephalopathy (EHM), a stroke-like syndrome following endothelial cell infection in horses. Both EHV-1 and EHV-9 infections of non-definitive hosts often result in neuronal infection and high case fatality rates. Hence, EHV-1 and EHV-9 are somewhat unusual herpesviruses and lack strict host specificity, and the true extent of their host ranges have remained unclear. In order to determine the seroprevalence of EHV-1 and EHV-9, a sensitive and specific peptide-based ELISA was developed and applied to 428 sera from captive and wild animals representing 30 species in 12 families and five orders...
2015: PloS One
https://www.readbyqxmd.com/read/26374414/cerebrovascular-complications-of-transorbital-penetrating-intracranial-injuries
#16
Yonca Özkan Arat, Anıl Arat, Kubilay Aydın
BACKGROUND: Cerebrovascular trauma secondary to transorbital intracranial penetrating injury (TIPVI) is rare. Relatively benign initial presentation may mask the underlying life-threatening vascular injury in transorbital intracranial penetrations. The aim of this study was to evaluate clinical features and endovascular treatment of TIPVI. METHODS: Six patients with angiographic documentation of TIPVI in subacute/chronic phase were reviewed retrospectively. Five were treated endovascularly; however endovascular treatment was aborted in one and conservative management was pursued...
July 2015: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/26350975/short-and-mid-term-results-after-transapical-transcatheter-aortic-valve-replacement-in-nonagenarians
#17
Andreas R DE Biasi, S Chiu Wong, Robert M Minutello, Konstantinos Voudris, Berhane Worku, Leonard N Girardi, Arash Salemi
BACKGROUND: Recent reports have suggested that advanced age may preclude favorable outcomes in transcatheter aortic valve replacement (TAVR), particularly when performed via transapical (TA) access. However, detailed examinations of TA-TAVR in nonagenarian patients are lacking in the contemporary literature. We therefore describe our experience with 25 consecutive nonagenarians who underwent TA-TAVR and report their short- and mid-term outcomes. METHODS: We identified all patients 90 years old or greater who underwent TA-TAVR between 2009-2014 at our institution...
February 2017: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/26240884/misoprostol-serious-cardiovascular-events-even-after-a-single-dose
#18
(no author information available yet)
A French Regional Pharmacovigilance Centre identified serious cardiovascular adverse effects linked to misoprostol and reported worldwide up to the end of 2012. Dozens of cases of myocardial infarction, angina and stroke had been reported, including after a single dose in gynaecology and obstetrics, for instance in elective abortion. This risk appears higher in smokers, women aged over 35 years, obese women, and after high-dose vaginal administration. The incidence is unknown. The bioavailability of misoprostol is higher with the vaginal than the oral route, especially when water is added to the tablet before vaginal administration...
July 2015: Prescrire International
https://www.readbyqxmd.com/read/26200771/thalamotomy-like-effects-from-partial-removal-of-a-ventral-intermediate-nucleus-deep-brain-stimulator-lead-in-a-patient-with-essential-tremor-case-report
#19
John D Rolston, Alexander D Ramos, Susan Heath, Dario J Englot, Daniel A Lim
BACKGROUND AND IMPORTANCE: The ventral intermediate nucleus of the thalamus is a primary target of deep brain stimulation (DBS) in patients with essential tremor. Despite reliable control of contralateral tremor, there is sometimes a need for lead revision in cases of infection, hardware malfunction, or failure to relieve symptoms. Here, we present the case of a patient undergoing revision after ventral intermediate nucleus (Vim) DBS failed to control his tremor. During the electrode removal, the distal portion of the lead was found to be tightly adherent to tissue within the deep brain...
November 2015: Neurosurgery
https://www.readbyqxmd.com/read/26188949/the-endocrine-dyscrasia-that-accompanies-menopause-and-andropause-induces-aberrant-cell-cycle-signaling-that-triggers-re-entry-of-post-mitotic-neurons-into-the-cell-cycle-neurodysfunction-neurodegeneration-and-cognitive-disease
#20
REVIEW
Craig S Atwood, Richard L Bowen
This article is part of a Special Issue "SBN 2014". Sex hormones are physiological factors that promote neurogenesis during embryonic and fetal development. During childhood and adulthood these hormones support the maintenance of brain structure and function via neurogenesis and the formation of dendritic spines, axons and synapses required for the capture, processing and retrieval of information (memories). Not surprisingly, changes in these reproductive hormones that occur with menopause and during andropause are strongly correlated with neurodegeneration and cognitive decline...
November 2015: Hormones and Behavior
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