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https://www.readbyqxmd.com/read/29166426/rhinology-future-debates-an-euforea-report
#1
W J Fokkens, C Bachert, M Bernal-Sprekelsen, J Bousquet, M Djandji, A Dorenbaum, D Hakimi-Mehr, S Hendry, C Hopkins, A Leunig, L Mannent, D Mucha, M Onerci, B Pugin, S Toppila-Salmi, P Rowe, S F Seys, S Stimson, A Strzembosz, P W Hellings
The first Rhinology Future Debates was held in Brussels in December 2016, organized by EUFOREA (European Forum for Research and Education in Allergy and Airways diseases). The purpose of these debates is to bring novel developments in the field of Rhinology to the attention of the medical, paramedical and patient community, in a highly credible and balanced context. For the first time in Rhinology, a peer to peer scientific exchange with key experts in the field of rhinology and key medical colleagues from leading industries let to a brainstorming and discussion event on a number of hot issues in Rhinology...
November 22, 2017: Rhinology
https://www.readbyqxmd.com/read/29131072/il-21-is-increased-in-nasal-polyposis-and-after-stimulation-with-staphylococcus-aureus-enterotoxin-b
#2
Lien Calus, Lara Derycke, Melissa Dullaers, Thibaut Van Zele, Natalie De Ruyck, Claudina Pérez-Novo, Gabriele Holtappels, Geert De Vos, Bart N Lambrecht, Claus Bachert, Philippe Gevaert
BACKGROUND: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is an inflammatory disease associated with lymphoid aggregates and local IgE production related to Staphylococcus aureus enterotoxins. T-follicular helper cells and their effector cytokine interleukin (IL)-21 play an important role in germinal center proliferation. METHODS: IL-21 was determined on the mRNA level by qPCR in nasal tissue of 3 groups of patients: control (n = 17), chronic rhinosinusitis without nasal polyposis (CRSsNP; n = 23), and CRSwNP (n = 35)...
November 9, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29112636/disseminated-peritoneal-leiomyomatosis
#3
Brandon J Bachert, Ripple S Patel
No abstract text is available yet for this article.
November 4, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29103995/ectopic-lymphoid-tissues-support-local-immunoglobulin-production-in-chronic-rhinosinusitis-with-nasal-polyps
#4
Jia Song, Hai Wang, Ya-Na Zhang, Ping-Ping Cao, Bo Liao, Zhe-Zheng Wang, Li-Li Shi, Yin Yao, Guan-Ting Zhai, Zhi-Chao Wang, Li-Meng Liu, Ming Zeng, Xiang Lu, Heng Wang, Xiang-Ping Yang, Di Yu, Claus Bachert, Zheng Liu
BACKGROUND: The contribution of ectopic lymphoid tissues (eLTs) to local immunoglobulin (Ig) hyperproduction in chronic rhinosinusitis with nasal polyps (CRSwNP) is unclear. OBJECTIVE: We sought to explore the cellular basis, formation mechanisms, and function of eLTs in CRSwNP. METHODS: We graded lymphoid aggregations in sinonasal mucosa and histologically studied their structures. The expression of lymphorganogenic factors and molecules required for Ig production was measured using real-time PCR and their localization was analyzed by immunohistochemistry and immunofluorescence...
November 2, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29075437/chrodis-criteria-applied-to-the-mask-macvia-aria-sentinel-network-good-practice-in-allergic-rhinitis-a-sunfrail-report
#5
REVIEW
J Bousquet, G L Onorato, C Bachert, M Barbolini, A Bedbrook, L Bjermer, J Correia de Sousa, N H Chavannes, A A Cruz, E De Manuel Keenoy, P Devillier, J Fonseca, S Hun, T Kostka, P W Hellings, M Illario, J C Ivancevich, D Larenas-Linnemann, J Millot-Keurinck, D Ryan, B Samolinski, A Sheikh, A Yorgancioglu, I Agache, S Arnavielhe, M Bewick, I Annesi-Maesano, J M Anto, K C Bergmann, C Bindslev-Jensen, S Bosnic-Anticevich, J Bouchard, D P Caimmi, P Camargos, G W Canonica, V Cardona, A M Carriazo, C Cingi, E Colgan, A Custovic, R Dahl, P Demoly, G De Vries, W J Fokkens, J F Fontaine, B Gemicioğlu, N Guldemond, Z Gutter, T Haahtela, B Hellqvist-Dahl, E Jares, G Joos, J Just, N Khaltaev, T Keil, L Klimek, M L Kowalski, I Kull, P Kuna, V Kvedariene, D Laune, R Louis, A Magnan, J Malva, E Mathieu-Dupas, E Melén, E Menditto, M Morais-Almeida, R Mösges, J Mullol, R Murray, H Neffen, R O'Hehir, S Palkonen, N G Papadopoulos, G Passalacqua, J L Pépin, F Portejoie, D Price, B Pugin, F Raciborski, F E R Simons, M Sova, O Spranger, C Stellato, A Todo Bom, P V Tomazic, M Triggiani, A Valero, E Valovirta, O VandenPlas, A Valiulis, M van Eerd, M T Ventura, M Wickman, I Young, T Zuberbier, A Zurkuhlen, A Senn
A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, is an example of a Good Practice focusing on the implementation of multi-sectoral care pathways using emerging technologies with real life data in rhinitis and asthma multi-morbidity. The European Union Joint Action on Chronic Diseases and Promoting Healthy Ageing across the Life Cycle (JA-CHRODIS) has developed a checklist of 28 items for the evaluation of Good Practices...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29046028/-aria-2016-executive-summary-integrated-care-pathways-for-predictive-medicine-throughout-the-life-cycle-in-argentina
#6
Juan Carlos Ivancevich, Hugo Neffen, Mario E Zernotti, Estrella Asayag, Ariel Blua, Alberto Cicerán, Edgardo J Jares, Alberto J Lavrut, Jorge F Máspero, Ioana Agache, Claus Bachert, Anna Bedbrook, Giorgio W Canonica, Thomas B Casale, Álvaro A Cruz, Wytske J Fokkens, Peter W Hellings, Boleslaw Samolinski, Jean Bousquet
The ARIA initiative was started during a World Health Organization workshop in 1999. The initial goals were to propose a new classification for allergic rhinitis, to promote the concept of multi-morbidity in asthma and rhinitis and to develop guidelines with stakeholders for world-wide use. ARIA is now focused on the implementation of emerging technologies for individualized and predictive medicine. MASK: MACVIA-Aria Sentinel Network uses mobile technology to develop care pathways that enable management by a multidisciplinary group or by patients themselves...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29030876/reproducibility-of-cmro2-determination-using-dynamic-17-o-mri
#7
Sebastian C Niesporek, Reiner Umathum, Jonathan M Lommen, Nicolas G R Behl, Daniel Paech, Peter Bachert, Mark E Ladd, Armin M Nagel
PURPOSE: To assess the reproducibility of (17) O MRI-based determination of the cerebral metabolic rate of oxygen consumption (CMRO2 ) in healthy volunteers. To assess the influence of image acquisition and reconstruction parameters on dynamic quantification of functional parameters such as CMRO2 . METHODS: Dynamic (17) O MRI data were simulated and used to investigate influences of temporal resolution (Δt) and partial volume correction (PVC) on the determination of CMRO2 ...
October 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29030102/lolium-perenne-peptides-for-treatment-of-grass-pollen-allergy-a-randomized-double-blind-placebo-controlled-clinical-trial
#8
Mohamed H Shamji, Jan Ceuppens, Claus Bachert, Peter Hellings, Gaël Placier, Gaëtan Thirion, Nicolas Bovy, Stephen R Durham, Jean Duchateau, Thierry Legon, Sabine Pirotton
No abstract text is available yet for this article.
October 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29027225/necroptotic-cell-death-in-anti-cancer-therapy
#9
REVIEW
Olga Krysko, Tania Løve Aaes, Valerian E Kagan, Katharina D'Herde, Claus Bachert, Luc Leybaert, Peter Vandenabeele, Dmitri V Krysko
Necroptosis is one the best-characterized forms of regulated necrosis. Necroptosis is mediated by the kinase activities of receptor interacting protein kinase-1 and receptor interacting protein kinase-3, which eventually lead to the activation of mixed lineage kinase domain-like. Necroptosis is characterized by rapid permeabilization of the plasma membrane, which is associated with the release of the cell content and subsequent exposure of damage-associated molecular patterns (DAMPs) and cytokines/chemokines...
November 2017: Immunological Reviews
https://www.readbyqxmd.com/read/29017832/impact-of-rhinitis-on-work-productivity-a-systematic-review
#10
Olivier Vandenplas, Denis Vinnikov, Paul D Blanc, Ioana Agache, Claus Bachert, Michael Bewick, Lars-Olaf Cardell, Paul Cullinan, Pascal Demoly, Alexis Descatha, Joao Fonseca, Tari Haahtela, Peter W Hellings, Jacques Jamart, Juha Jantunen, Ömer Kalayci, David Price, Boleslaw Samolinski, Joaquin Sastre, Longxiu Tian, Antonio L Valero, Xinyi Zhang, Jean Bousquet
BACKGROUND: Allergic rhinitis (AR) is increasingly acknowledged as having a substantial socioeconomic impact associated with impaired work productivity, although available information remains fragmented. OBJECTIVE: This systematic review summarizes recently available information to provide a quantitative estimate of the burden of AR on work productivity including lost work time (ie, absenteeism) and reduced performance while working (ie, presenteeism). METHODS: A Medline search retrieved original studies from 2005 to 2015 pertaining to the impact of AR on work productivity...
October 7, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28987810/chronic-rhinosinusitis-in-asia
#11
Yuan Zhang, Elien Gevaert, Hongfei Lou, Xiangdong Wang, Luo Zhang, Claus Bachert, Nan Zhang
Chronic rhinosinusitis (CRS), although possibly overdiagnosed, is associated with a high burden of disease and is often difficult to treat in those truly affected. Recent research has demonstrated that inflammatory signatures of CRS vary around the world, with less eosinophilic and more neutrophilic inflammation found in Asia compared with Europe and North America. Although in the Western world about 80% of nasal polyps carry a type 2 signature, this might be between 20% and 60% in China and Korea or Thailand, respectively...
October 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28941667/advances-and-highlights-in-allergen-immunotherapy-on-the-way-to-sustained-clinical-and-immunologic-tolerance
#12
Margot Berings, Cagatay Karaaslan, Can Altunbulakli, Philippe Gevaert, Mübeccel Akdis, Claus Bachert, Cezmi A Akdis
Allergen immunotherapy (AIT) is an effective treatment strategy for allergic diseases and has been used for more than 100 years. In recent years, however, the expectations on concepts, conduct, statistical evaluation, and reporting have developed significantly. Products have undergone dose-response and confirmative studies in adults and children to provide evidence for the optimal dosage, safety, and efficacy of AIT vaccines using subcutaneous and sublingual delivery pathways in large patient cohorts, ensuring solid conclusions to be drawn from them for the advantage of patients and societies alike...
November 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28927818/specific-allergy-asthma-prevention-coming-to-an-age-a-milestone-in-children
#13
EDITORIAL
Claus Bachert, Cezmi Akdis
No abstract text is available yet for this article.
September 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28906011/the-allergic-rhinitis-and-its-impact-on-asthma-aria-score-of-allergic-rhinitis-using-mobile-technology-correlates-with-quality-of-life-the-mask-study
#14
J Bousquet, S Arnavielhe, A Bedbrook, J Fonseca, M Morais Almeida, A Todo Bom, I Annesi-Maesano, D Caimmi, P Demoly, P Devillier, V Siroux, E Menditto, G Passalacqua, C Stellato, M T Ventura, A A Cruz, F Sarquis Serpa, J da Silva, D Larenas-Linnemann, M Rodriguez Gonzalez, M T Burguete Cabañas, K C Bergmann, T Keil, L Klimek, R Mösges, S Shamai, T Zuberbier, M Bewick, D Price, D Ryan, A Sheikh, J M Anto, J Mullol, A Valero, T Haahtela, E Valovirta, W J Fokkens, P Kuna, B Samolinski, C Bindslev-Jensen, E Eller, S Bosnic-Anticevich, R E O'Hehir, P V Tomazic, A Yorgancioglu, B Gemicioglu, C Bachert, P W Hellings, I Kull, E Melén, M Wickman, M van Eerd, G De Vries
Mobile technology has been used to appraise allergic rhinitis control, but more data are needed. To better assess the importance of mobile technologies in rhinitis control, the ARIA (Allergic Rhinitis and its Impact on Asthma) score ranging from 0 to 4 of the Allergy Diary was compared with EQ-5D (EuroQuol) and WPAI-AS (Work Productivity and Activity Impairment in allergy) in 1288 users in 18 countries. This study showed that quality-of-life data (EQ-5D visual analogue scale and WPA-IS Question 9) are similar in users without rhinitis and in those with mild rhinitis (scores 0-2)...
September 14, 2017: Allergy
https://www.readbyqxmd.com/read/28870464/serum-periostin-ige-and-se-ige-can-be-used-as-biomarkers-to-identify-moderate-to-severe-chronic-rhinosinusitis-with-nasal-polyps
#15
Karin Jonstam, Marit Westman, Gabriële Holtappels, Cecile T J Holweg, Claus Bachert
No abstract text is available yet for this article.
September 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28839248/sensitization-patterns-and-minimum-screening-panels-for-aeroallergens-in-self-reported-allergic-rhinitis-in-china
#16
Hongfei Lou, Siyuan Ma, Yan Zhao, Feifei Cao, Fei He, Zhongyan Liu, Jean Bousquet, Chengshuo Wang, Luo Zhang, Claus Bachert
Optimization of skin prick test (SPT) panels, especially in view of significant differences in sensitizations patterns within different geographical areas, is an unmet need within China. Our aim was to assess the patterns and clinical relevance of aeroallergen sensitizations in allergic rhinitis (AR) and define the minimal battery of SPT allergens, classified according to the Köppen-Geiger climate map. Overall, 7148 subjects with self-reported AR completed a standard questionnaire and were assessed for sensitization to relevant allergens by SPT...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28817656/investigation-of-the-halo-artifact-in-68ga-psma-11-pet-mri
#17
Thorsten Heußer, Philipp Mann, Christopher M Rank, Martin Schäfer, Antonia Dimitrakopoulou-Strauss, Heinz-Peter Schlemmer, Boris A Hadaschik, Klaus Kopka, Peter Bachert, Marc Kachelrieß, Martin T Freitag
OBJECTIVES: Combined positron emission tomography (PET) and magnetic resonance imaging (MRI) targeting the prostate-specific membrane antigen (PSMA) with a 68Ga-labelled PSMA-analog (68Ga-PSMA-11) is discussed as a promising diagnostic method for patients with suspicion or history of prostate cancer. One potential drawback of this method are severe photopenic (halo-) artifacts surrounding the bladder and the kidneys in the scatter-corrected PET images, which have been reported to occur frequently in clinical practice...
2017: PloS One
https://www.readbyqxmd.com/read/28687232/reduced-need-for-surgery-in-severe-nasal-polyposis-with-mepolizumab-randomized-trial
#18
RANDOMIZED CONTROLLED TRIAL
Claus Bachert, Ana R Sousa, Valerie J Lund, Glenis K Scadding, Philippe Gevaert, Shuaib Nasser, Stephen R Durham, Marjolein E Cornet, Harsha H Kariyawasam, Jane Gilbert, Daren Austin, Aoife C Maxwell, Richard P Marshall, Wytske J Fokkens
BACKGROUND: Patients with eosinophilic nasal polyposis frequently require surgery, and recurrence rates are high. OBJECTIVE: We sought to assess the efficacy and safety of mepolizumab versus placebo for severe bilateral nasal polyposis. METHODS: This randomized, double-blind, placebo-controlled trial recruited patients aged 18 to 70 years with recurrent nasal polyposis requiring surgery. Patients received 750 mg of intravenous mepolizumab or placebo every 4 weeks for a total of 6 doses in addition to daily topical corticosteroid treatment...
October 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28646889/apps-to-improve-diet-physical-activity-and-sedentary-behaviour-in-children-and-adolescents-a-review-of-quality-features-and-behaviour-change-techniques
#19
Stephanie Schoeppe, Stephanie Alley, Amanda L Rebar, Melanie Hayman, Nicola A Bray, Wendy Van Lippevelde, Jens-Peter Gnam, Philip Bachert, Artur Direito, Corneel Vandelanotte
BACKGROUND: The number of commercial apps to improve health behaviours in children is growing rapidly. While this provides opportunities for promoting health, the content and quality of apps targeting children and adolescents is largely unexplored. This review systematically evaluated the content and quality of apps to improve diet, physical activity and sedentary behaviour in children and adolescents, and examined relationships of app quality ratings with number of app features and behaviour change techniques (BCTs) used...
June 24, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28639310/high-resolution-31-p-echo-planar-spectroscopic-imaging-in-vivo-at-7t
#20
Andreas Korzowski, Peter Bachert
PURPOSE: Conventional (31) P chemical shift imaging is time-consuming and yields only limited spatial resolution. The purpose of this study was to demonstrate feasibility of (31) P echo-planar spectroscopic imaging (EPSI) in vivo at 7T. METHODS: A 3D (31) P EPSI sequence with trapezoidal-shaped gradient pulses was implemented on a 7T MR scanner. To increase spectral width with reduced demand on gradient performance, a multishot approach was chosen. Acquisition weighting and (31) P-{(1) H} double resonance for nuclear Overhauser signal enhancement were applied to increase sensitivity...
June 21, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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