keyword
MENU ▼
Read by QxMD icon Read
search

Bachert

keyword
https://www.readbyqxmd.com/read/29768034/staphylococcus-aureus-induces-mucosal-type-2-immune-response-via-epithelial-cell-derived-cytokines
#1
Feng Lan, Nan Zhang, Gabriele Holtappels, Natalie De Ruyck, Olga Krysko, Koen Van Crombruggen, Harald Braun, Sebastian L Johnston, Nikos G Papadopoulos, Luo Zhang, Claus Bachert
RATIONALE: Chronic rhinosinusitis with nasal polyps is characterized by a T helper cell 2-skewed upper airway inflammation. Mucosal Staphylococcus aureus colonization is found in the majority of nasal polyps patients. Staphylococcus aureus is known to induce type 2 cytokine release via enterotoxins. OBJECTIVES: We investigated the impact of non-enterotoxin producing Staphylococcus aureus on type 2 cytokine release. METHODS: Thymic stromal lymphopoietin, interleukin-33 and type 2 cytokines were assessed in a human mucosal tissue model upon Staphylococcus aureus infection...
May 16, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29733378/assessing-the-predictability-of-idh-mutation-and-mgmt-methylation-status-in-glioma-patients-using-relaxation-compensated-multi-pool-cest-mri-at-7-0-tesla
#2
Daniel Paech, Johannes Windschuh, Johanna Oberhollenzer, Constantin Dreher, Felix Sahm, Jan-Eric Meissner, Steffen Goerke, Patrick Schuenke, Moritz Zaiss, Sebastian Regnery, Sebastian Bickelhaupt, Philipp Bäumer, Martin Bendszus, Wolfgang Wick, Andreas Unterberg, Peter Bachert, Mark Edward Ladd, Heinz-Peter Schlemmer, Alexander Radbruch
Background: Early identification of prognostic superior characteristics in glioma patients such as Isocitrate dehydrogenase(IDH)-mutation and O6-methylguanine-DNA-methyltransferase (MGMT) promotor methylation status is of great clinical importance. The study purpose was to investigate the non-invasive predictability of IDH-mutation status, MGMT promotor methylation, and differentiation of lower versus higher grade glioma (LGG vs. HGG) in newly-diagnosed patients employing relaxation-compensated multi-pool Chemical Exchange Saturation Transfer (CEST) magnetic resonance imaging (MRI) at 7...
May 4, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29731100/endotype-driven-care-pathways-in-patients-with-chronic-rhinosinusitis
#3
REVIEW
Claus Bachert, Nan Zhang, Peter W Hellings, Jean Bousquet
Chronic rhinosinusitis (CRS) has been differentiated clinically into CRS without nasal polyps and CRS with nasal polyps, with both forms subjected to glucocorticosteroid and antibiotic treatments and, if not successful, to nasal and sinus surgery tailored to endoscopic and computed tomographic scan findings. The elaboration of endotypes based on pathomechanisms involving different immune responses offers new possibilities in terms of prediction of prognosis and risks and sophisticated guidance in personalized pharmacotherapy, surgical approaches, and innovative treatment approaches in the CRS field with various biologics...
May 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29682789/fc%C3%AE%C2%B5ri-expression-and-ige-binding-by-dendritic-cells-and-basophils-in-allergic-rhinitis-and-upon-allergen-immunotherapy
#4
Margot Berings, Philippe Gevaert, Natalie De Ruyck, Lara Derycke, Gabriële Holtappels, Charles Pilette, Claus Bachert, Bart N Lambrecht, Melissa Dullaers
BACKGROUND: In humans, both basophils and dendritic cells (DCs) express the high affinity IgE receptor (FcεRI). OBJECTIVE: To gain more insight in the relation between serum IgE levels and FcεRI expression and IgE binding by DCs and basophils in house dust mite (HDM) allergy and during subcutaneous immunotherapy (SCIT). METHODS: We measured FcεRI, IgE and HDM allergen on DCs (conventional type 2 DCs, cDC2s; plasmacytoid dendritic cells, pDCs) and basophils by flow cytometry in 22 non-allergic versus 52 allergic subjects, and upon HDM SCIT in 28 allergic subjects...
April 22, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29672976/dual-frequency-irradiation-cest-mri-of-endogenous-bulk-mobile-proteins
#5
Steffen Goerke, Johannes Breitling, Moritz Zaiss, Johannes Windschuh, Patrick Kunz, Patrick Schuenke, Daniel Paech, Dario L Longo, Karel D Klika, Mark E Ladd, Peter Bachert
A novel MRI contrast is proposed which enables the selective detection of endogenous bulk mobile proteins in vivo. Such a non-invasive imaging technique may be of particular interest for many diseases associated with pathological alterations of protein expression, such as cancer and neurodegenerative disorders. Specificity to mobile proteins was achieved by the selective measurement of intramolecular spin diffusion and the removal of semi-solid macromolecular signal components by a correction procedure. For this purpose, the approach of chemical exchange saturation transfer (CEST) was extended to a radiofrequency (RF) irradiation scheme at two different frequency offsets (dualCEST)...
April 19, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29569295/daily-allergic-multimorbidity-in-rhinitis-using-mobile-technology-a-novel-concept-of-the-mask-study
#6
REVIEW
J Bousquet, P Devillier, J M Anto, M Bewick, T Haahtela, S Arnavielhe, A Bedbrook, R Murray, M van Eerd, J A Fonseca, M Morais Almeida, A Todo Bom, E Menditto, G Passalacqua, C Stellato, M Triggiani, M T Ventura, G Vezzani, I Annesi-Maesano, R Bourret, I Bosse, D Caimmi, C Cartier, P Demoly, J Just, F Portejoie, V Siroux, F Viart, K C Bergmann, T Keil, L Klimek, R Mösges, O Pfaar, S Shamai, T Zuberbier, J Mullol, A Valero, O Spranger, P V Tomazic, M L Kowalski, P Kuna, M Kupczyk, F Raciborski, B Samolinski, S K Toppila-Salmi, E Valovirta, A A Cruz, F Sarquis-Serpa, J da Silva, R Stelmach, D Larenas-Linnemann, M Rodriguez Gonzalez, M T Burguete Cabañas, V Kvedariene, A Valiulis, N H Chavannes, W J Fokkens, D Ryan, A Sheikh, C Bachert, P W Hellings, O VandenPlas, N Ballardini, I Kull, E Melén, M Westman, M Wickman, C Bindslev-Jensen, E Eller, S Bosnic-Anticevich, R E O'Hehir, I Agache, T Bieber, T Casale, B Gemicioğlu, J C Ivancevich, G De Vries, M Sorensen, A Yorgancioglu, D Laune
BACKGROUND: Multimorbidity in allergic airway diseases is well known, but no data exist about the daily dynamics of symptoms and their impact on work. To better understand this, we aimed to assess the presence and control of daily allergic multimorbidity (asthma, conjunctivitis, rhinitis) and its impact on work productivity using a mobile technology, the Allergy Diary, METHODS: We undertook a one year prospective observational study in which 4,210 users and 32,585 days were monitored in 19 countries...
March 22, 2018: Allergy
https://www.readbyqxmd.com/read/29518417/staphylococcus-aureus-enhances-the-tight-junction-barrier-integrity-in-healthy-nasal-tissue-but-not-in-nasal-polyps
#7
Can Altunbulakli, Rita Costa, Feng Lan, Nan Zhang, Mubeccel Akdis, Claus Bachert, Cezmi A Akdis
No abstract text is available yet for this article.
March 5, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29512854/contribution-of-repeated-infections-in-asthma-persistence-from-preschool-to-school-age-design-and-characteristics-of-the-predicta-cohort
#8
Paraskevi Xepapadaki, Claus Bachert, Susetta Finotto, Tuomas Jartti, George N Konstantinou, Alexander Kiefer, Marek Kowalski, Anna Lewandowska-Polak, Heikki Lukkarinen, Eirini Roumpedaki, Anna Sobanska, Ina Sintobin, Tytti Vuorinen, Nan Zhang, Theodor Zimmermann, Nikolaos G Papadopoulos
BACKGROUND: The PreDicta cohort was designed to prospectively evaluate wheeze/asthma persistence in preschoolers in association with viral/microbial exposures and immunological responses. We present the cohort design and demographic/disease characteristics and evaluate unsupervised and predefined phenotypic subgroups at inclusion. METHODS: PreDicta is a 2-year prospective study conducted in five European regions, including children 4-6 years with a diagnosis of asthma as cases and healthy age-matched controls...
March 7, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29512827/short-course-of-grass-allergen-peptides-immunotherapy-over-three-weeks-reduces-seasonal-symptoms-in-allergic-rhinoconjunctivitis-with-without-asthma-a-randomized-multicenter-double-blind-placebo-controlled-trial
#9
Ralph Mösges, Claus Bachert, Petr Panzner, Moises A Calderon, Ludo Haazen, Sabine Pirotton, Nathalie Wathelet, Stephen R Durham, Marie-Alix Bonny, Thierry Legon, Remy von Frenckell, Oliver Pfaar, Mohamed H Shamji
BACKGROUND: Immunotherapy with peptide hydrolysates from Lolium perenne (LPP) is an alternative treatment for seasonal allergic rhinitis with or without asthma. The aim of this study was to assess the clinical efficacy and safety of a cumulative dose of 170 μg LPP administered subcutaneously over 3 weeks. METHODS: In a randomized, double blind, placebo-controlled trial, 554 adults with grass pollen rhinoconjunctivitis were randomized (1:2 ratio) to receive 8 subcutaneous injections of placebo or 170 μg LPP administered in increasing doses in 4 visits over 3 weeks...
March 7, 2018: Allergy
https://www.readbyqxmd.com/read/29466477/mysinusitiscoach-patient-empowerment-in-chronic-rhinosinusitis-using-mobile-technology
#10
S F Seys, J Bousquet, C Bachert, W J Fokkens, I Agache, M Bernal-Sprekelsen, I Callebaut, L O Cardel, S Carrie, P Castelnuovo, R Cathcart, J Constantinidis, L Cools, M Cornet, G Clement, J C de Sousa, T Cox, M Doulaptsi, P Gevaert, C Hopkins, V Hox, T Hummel, W Hosemann, R Jacobs, M Jorissen, B N Landis, A Leunig, V J Lund, J Mullol, M Onerci, S Palkonen, I Proano, E Prokopakis, D Ryan, H Riechelmann, J Saevels, C Segboer, K Speleman, E A Steinsvik, P Surda, P V Tomazic, O Vanderveken, L Van Gerven, T Van Zele, B Verhaeghe, K Vierstraete, S Vlaminck, J Wilkinson, S Williams, B Pugin, P W Hellings
Mobile health technology is emerging to take a prominent position in the management of chronic diseases. These technologies aim at enhancing patient empowerment via education and self-management. To date, of all the different apps available for patients with sinus disease, none were developed by medical experts dealing with chronic rhinosinusitis (CRS). The European Forum for Research and Education in Allergy and Airway diseases (EUFOREA) has undertaken a multi-stakeholder approach for designing, developing and implementing a tool to support CRS patients in monitoring their symptoms and to provide patients with a digital support platform containing reliable medical information about their disease and treatment options...
February 21, 2018: Rhinology
https://www.readbyqxmd.com/read/29447326/prospective-study-on-the-outcome-of-the-sphenoid-drill-out-procedure
#11
T Van Zele, B Pauwels, F Dewaele, P Gevaert, C Bachert
BACKGROUND: Chronic sphenoid sinusitis refractory to both medical therapy and sphenoidotomy requires a more extended intervention based on the principles of salvage surgery. Our aim is to describe the sphenoid drill out technique as a sphenoid salvage intervention and to outline its implications on clinical outcome and quality of life. METHODOLOGY: 12 patients with chronic sphenoiditis undergoing a sphenoid drill out procedure were examined by nasal endoscopy preoperatively and postoperatively for one year...
February 15, 2018: Rhinology
https://www.readbyqxmd.com/read/29438602/international-consensus-statement-on-allergy-and-rhinology-allergic-rhinitis
#12
Sarah K Wise, Sandra Y Lin, Elina Toskala, Richard R Orlandi, Cezmi A Akdis, Jeremiah A Alt, Antoine Azar, Fuad M Baroody, Claus Bachert, G Walter Canonica, Thomas Chacko, Cemal Cingi, Giorgio Ciprandi, Jacquelynne Corey, Linda S Cox, Peter Socrates Creticos, Adnan Custovic, Cecelia Damask, Adam DeConde, John M DelGaudio, Charles S Ebert, Jean Anderson Eloy, Carrie E Flanagan, Wytske J Fokkens, Christine Franzese, Jan Gosepath, Ashleigh Halderman, Robert G Hamilton, Hans Jürgen Hoffman, Jens M Hohlfeld, Steven M Houser, Peter H Hwang, Cristoforo Incorvaia, Deborah Jarvis, Ayesha N Khalid, Maritta Kilpeläinen, Todd T Kingdom, Helene Krouse, Desiree Larenas-Linnemann, Adrienne M Laury, Stella E Lee, Joshua M Levy, Amber U Luong, Bradley F Marple, Edward D McCoul, K Christopher McMains, Erik Melén, James W Mims, Gianna Moscato, Joaquim Mullol, Harold S Nelson, Monica Patadia, Ruby Pawankar, Oliver Pfaar, Michael P Platt, William Reisacher, Carmen Rondón, Luke Rudmik, Matthew Ryan, Joaquin Sastre, Rodney J Schlosser, Russell A Settipane, Hemant P Sharma, Aziz Sheikh, Timothy L Smith, Pongsakorn Tantilipikorn, Jody R Tversky, Maria C Veling, De Yun Wang, Marit Westman, Magnus Wickman, Mark Zacharek
BACKGROUND: Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR). METHODS: Using previously described methodology, specific topics were developed relating to AR...
February 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29427389/in-vivo-self-gated-23-na-mri-at-7-t-using-an-oval-shaped-body-resonator
#13
Tanja Platt, Reiner Umathum, Thomas M Fiedler, Armin M Nagel, Andreas K Bitz, Florian Maier, Peter Bachert, Mark E Ladd, Mark O Wielpütz, Hans-Ulrich Kauczor, Nicolas G R Behl
PURPOSE: This work faces three challenges of sodium (23 Na) torso MRI on the way to quantitative 23 Na MRI: Development of a 23 Na radiofrequency transmit and receive coil covering a large part of the human body in width and length for 23 Na MRI at 7 T; reduction of blurring due to respiration in free-breathing 23 Na MRI using a self-gating approach; and reduction of image noise using a compressed-sensing reconstruction. METHODS: An oval-shaped birdcage resonator with a large field of view of (400 mm)3 and a homogeneous transmit and receive field distribution was designed, simulated, and implemented on a 7T MR system...
February 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29380390/eaaci-guidelines-on-allergen-immunotherapy-executive-statement
#14
EDITORIAL
A Muraro, G Roberts, S Halken, I Agache, E Angier, M Fernandez-Rivas, R Gerth van Wijk, M Jutel, S Lau, G Pajno, O Pfaar, D Ryan, G J Sturm, R van Ree, E-M Varga, C Bachert, M Calderon, G W Canonica, S R Durham, H J Malling, U Wahn, A Sheikh
No abstract text is available yet for this article.
April 2018: Allergy
https://www.readbyqxmd.com/read/29367682/activation-of-activin-receptor-like-kinases-curbs-mucosal-inflammation-and-proliferation-in-chronic-rhinosinusitis-with-nasal-polyps
#15
Lotta Tengroth, Julia Arebro, Olivia Larsson, Claus Bachert, Susanna Kumlien Georén, Lars-Olaf Cardell
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a widespread disease causing obstruction of the nasal cavity. Its cause remains unclear. The transforming growth-factor beta (TGF-β) superfamily and their receptors, termed Activin receptor-like kinases (ALKs), have recently been suggested to play a role in local airway inflammation, but have so far not been evaluated in human nasal epithelial cells (HNECs) from CRSwNP patients. We demonstrated that ALK1-7 were expressed in the nasal polyp epithelium, and the expression of ALK1-6 was markedly elevated in polyps compared to nasal mucosa from healthy controls...
January 24, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29344985/probing-the-microscopic-environment-of-23-na-ions-in-brain-tissue-by-mri-on-the-accuracy-of-different-sampling-schemes-for-the-determination-of-rapid-biexponential-t2-decay-at-low-signal-to-noise-ratio
#16
Jonathan M Lommen, Sebastian Flassbeck, Nicolas G R Behl, Sebastian Niesporek, Peter Bachert, Mark E Ladd, Armin M Nagel
PURPOSE: To investigate and to reduce influences on the determination of the short and long apparent transverse relaxation times ( T2,s*, T2,l*) of 23 Na in vivo with respect to signal sampling. METHODS: The accuracy of T2* determination was analyzed in simulations for five different sampling schemes. The influence of noise in the parameter fit was investigated for three different models. A dedicated sampling scheme was developed for brain parenchyma by numerically optimizing the parameter estimation...
January 17, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29342980/dietary-intake-of-flavonoids-and-ventilatory-function-in-european-adults-a-ga%C3%A2-len-study
#17
Vanessa Garcia-Larsen, Narjis Thawer, David Charles, Aedin Cassidy, Thibaut van Zele, Trine Thilsing, Matti Ahlström, Tari Haahtela, Thomas Keil, Paolo M Matricardi, Grzegorz Brożek, Marek L Kowalski, Joanna Makowska, Ewa Niżankowska-Mogilnicka, Barbara Rymarczyk, Carlos Loureiro, Ana Todo Bom, Claus Bachert, Bertil Forsberg, Christer Janson, Kjell Torén, James F Potts, Peter Gj Burney
BACKGROUND: Flavonoids exert anti-inflammatory properties and modulate oxidative stress in vitro, suggesting a protective effect on lung function, but epidemiological studies examining this association are scarce. METHODS: A stratified random sample was drawn from the GA²LEN screening survey, in which 55,000 adults aged 15 to 75 answered a questionnaire on respiratory symptoms. Post-bronchodilator spirometry was obtained from 2850 subjects. Forced vital capacity (FVC), the ratio between the forced exhaled volume in 1 second (FEV₁) and FVC (FEV₁/FVC), FVC below lower limit of normal (FVC < LLN), and FEV₁/FVC < LLN were calculated...
January 15, 2018: Nutrients
https://www.readbyqxmd.com/read/29336067/treatment-of-allergic-rhinitis-using-mobile-technology-with-real-world-data-the-mask-observational-pilot-study
#18
REVIEW
J Bousquet, P Devillier, S Arnavielhe, A Bedbrook, G Alexis-Alexandre, M van Eerd, R Murray, G W Canonica, M Illario, E Menditto, G Passalacqua, C Stellato, M Triggiani, P Carreiro-Martins, J Fonseca, M Morais Almeida, L Nogueira-Silva, A M Pereira, A Todo Bom, I Bosse, D Caimmi, P Demoly, J F Fontaine, J Just, G L Onorato, M L Kowalski, P Kuna, B Samolinski, J M Anto, J Mullol, A Valero, P V Tomazic, K C Bergmann, T Keil, L Klimek, R Mösges, S Shamai, T Zuberbier, E Murphy, P McDowall, D Price, D Ryan, A Sheikh, N H Chavannes, W J Fokkens, V Kvedariene, A Valiulis, C Bachert, P W Hellings, I Kull, E Melen, M Wickman, C Bindslev-Jensen, E Eller, T Haahtela, N G Papadopoulos, I Annesi-Maesano, M Bewick, S Bosnic-Anticevich, A A Cruz, G De Vries, B Gemicioglu, D Larenas-Linnemann, D Laune, E Mathieu-Dupas, R E O'Hehir, O Pfaar, F Portejoie, V Siroux, O Spranger, E Valovirta, O VandenPlas, A Yorgancioglu
BACKGROUND: Large observational implementation studies are needed to triangulate the findings from randomized control trials as they reflect "real-world" everyday practice. In a pilot study, we attempted to provide additional and complementary insights on the real-life treatment of allergic rhinitis (AR) using mobile technology. METHODS: A mobile phone app (Allergy Diary, freely available in Google Play and Apple App stores) collects the data of daily visual analog scales (VAS) for (i) overall allergic symptoms, (ii) nasal, ocular, and asthma symptoms, (iii) work, as well as (iv) medication use using a treatment scroll list including all medications (prescribed and over the counter (OTC)) for rhinitis customized for 15 countries...
January 15, 2018: Allergy
https://www.readbyqxmd.com/read/29315616/in-chronic-spontaneous-urticaria-ige-against-staphylococcal-enterotoxins-is-common-and-functional
#19
S Altrichter, T Hawro, M Liedtke, G Holtappels, C Bachert, P S Skov, M Maurer
BACKGROUND: Chronic spontaneous urticaria (CSU) is a frequent disorder with recurrent itchy wheals and/or angioedema. Despite the known effectiveness of omalizumab therapy, the relevant IgE antigens are largely unknown. Recently, increased rates of elevated levels of IgE towards Staphylococcus aureus enterotoxins (SEs) were described in CSU. AIM: To assess the prevalence and functional relevance of IgE to SEs in CSU. METHOD: We investigated serum levels of IgE against SEs in 49 CSU patients and in 15 CSU patients additional specific IgE to SE components and basophil histamine release (BHR)...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29247803/staphylococcus-aureus-controls-interleukin-5-release-in-upper-airway-inflammation
#20
C Bachert, G Holtappels, M Merabishvili, T Meyer, A Murr, N Zhang, K Van Crombruggen, E Gevaert, U Völker, B M Bröker, M Vaneechoutte, F Schmidt
Staphylococcus aureus is a frequent colonizer of the upper airways in chronic rhinosinusitis with nasal polyps, but also resides intramucosally; it has been shown that secreted staphylococcal proteins such as enterotoxins and serine proteases induce the release of cytokines such as IL-5. We have analyzed nasal polyp tissue freshly obtained during routine surgery, which did or did not contain cultivatable S. aureus, to study spontaneous IL-5 production by nasal polyp tissue over 24 and 72h in tissue culture...
December 13, 2017: Journal of Proteomics
keyword
keyword
103338
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"