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https://www.readbyqxmd.com/read/28941667/advances-and-highlights-in-allergen-immunotherapy-on-the-way-to-sustained-clinical-and-immunologic-tolerance
#1
Margot Berings, Cagatay Karaaslan, Can Altunbulakli, Philippe Gevaert, Mübeccel Akdis, Claus Bachert, Cezmi A Akdis
Allergen immunotherapy (AIT) is an effective treatment strategy for allergic diseases and has been used for more than 100 years. In recent years, however, the expectations on concepts, conduct, statistical evaluation and reporting have been significantly developed. Products have undergone dose-response and confirmative studies in adults and children to provide evidence for the optimal dosage, safety and efficacy of AIT vaccines using subcutaneous and sublingual delivery pathways in large patient cohorts, ensuring solid conclusions to be drawn from them for the advantage of patients and societies alike...
September 20, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28927818/specific-allergy-asthma-prevention-coming-to-an-age-a-milestone-in-children
#2
EDITORIAL
Claus Bachert, Cezmi Akdis
No abstract text is available yet for this article.
September 16, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28906011/the-aria-score-of-allergic-rhinitis-using-mobile-technology-correlates-with-quality-of-life-the-mask-study
#3
J Bousquet, S Arnavielhe, A Bedbrook, J Fonseca, M Morais Almeida, A Todo Bom, I Annesi-Maesano, D Caimmi, P Demoly, P Devillier, V Siroux, E Menditto, G Passalacqua, C Stellato, M T Ventura, A A Cruz, F S Serpa, J da Silva, D Larenas-Linnemann, M Rodriguez Gonzalez, M T Burguete Cabañas, K C Bergmann, T Keil, L Klimek, R Mösges, S Shamai, T Zuberbier, M Bewick, D Price, D Ryan, A Sheikh, J M Anto, J Mullol, A Valero, T Haahtela, E Valovirta, W J Fokkens, P Kuna, B Samolinski, C Bindslev-Jensen, E Eller, S Bosnic-Anticevich, R E O'Hehir, P V Tomazic, A Yorgancioglu, B Gemicioglu, C Bachert, P W Hellings, I Kull, E Melén, M Wickman, M van Eerd, G De Vries
Mobile technology has been used to appraise allergic rhinitis control but more data are needed. In order to better assess the importance of mobile technologies in rhinitis control, the ARIA (Allergic Rhinitis and its Impact on Asthma) score ranging from 0 to 4 of the Allergy Diary was compared with EQ-5D (EuroQuol) and WPAI-AS (Work Productivity and Activity Impairment in allergy) in 1,288 users in 18 countries. This study showed that quality-of-life data (EQ-5D visual analogue scale and WPA-IS Question 9) are similar in users without rhinitis and in those with mild rhinitis (scores 0-2)...
September 14, 2017: Allergy
https://www.readbyqxmd.com/read/28870464/serum-periostin-ige-and-se-ige-can-be-used-as-biomarkers-to-identify-moderate-to-severe-chronic-rhinosinusitis-with-nasal-polyps
#4
Karin Jonstam, Marit Westman, Gabriële Holtappels, Cecile T J Holweg, Claus Bachert
No abstract text is available yet for this article.
September 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28839248/sensitization-patterns-and-minimum-screening-panels-for-aeroallergens-in-self-reported-allergic-rhinitis-in-china
#5
Hongfei Lou, Siyuan Ma, Yan Zhao, Feifei Cao, Fei He, Zhongyan Liu, Jean Bousquet, Chengshuo Wang, Luo Zhang, Claus Bachert
Optimization of skin prick test (SPT) panels, especially in view of significant differences in sensitizations patterns within different geographical areas, is an unmet need within China. Our aim was to assess the patterns and clinical relevance of aeroallergen sensitizations in allergic rhinitis (AR) and define the minimal battery of SPT allergens, classified according to the Köppen-Geiger climate map. Overall, 7148 subjects with self-reported AR completed a standard questionnaire and were assessed for sensitization to relevant allergens by SPT...
August 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28817656/investigation-of-the-halo-artifact-in-68ga-psma-11-pet-mri
#6
Thorsten Heußer, Philipp Mann, Christopher M Rank, Martin Schäfer, Antonia Dimitrakopoulou-Strauss, Heinz-Peter Schlemmer, Boris A Hadaschik, Klaus Kopka, Peter Bachert, Marc Kachelrieß, Martin T Freitag
OBJECTIVES: Combined positron emission tomography (PET) and magnetic resonance imaging (MRI) targeting the prostate-specific membrane antigen (PSMA) with a 68Ga-labelled PSMA-analog (68Ga-PSMA-11) is discussed as a promising diagnostic method for patients with suspicion or history of prostate cancer. One potential drawback of this method are severe photopenic (halo-) artifacts surrounding the bladder and the kidneys in the scatter-corrected PET images, which have been reported to occur frequently in clinical practice...
2017: PloS One
https://www.readbyqxmd.com/read/28687232/reduced-need-for-surgery-in-severe-nasal-polyposis-with-mepolizumab-randomized-trial
#7
Claus Bachert, Ana R Sousa, Valerie J Lund, Glenis K Scadding, Philippe Gevaert, Shuaib Nasser, Stephen R Durham, Marjolein E Cornet, Harsha H Kariyawasam, Jane Gilbert, Daren Austin, Aoife C Maxwell, Richard P Marshall, Wytske J Fokkens
BACKGROUND: Patients with eosinophilic nasal polyposis frequently require surgery, and recurrence rates are high. OBJECTIVE: We sought to assess the efficacy and safety of mepolizumab versus placebo for severe bilateral nasal polyposis. METHODS: This randomized, double-blind, placebo-controlled trial recruited patients aged 18 to 70 years with recurrent nasal polyposis requiring surgery. Patients received 750 mg of intravenous mepolizumab or placebo every 4 weeks for a total of 6 doses in addition to daily topical corticosteroid treatment...
July 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28646889/apps-to-improve-diet-physical-activity-and-sedentary-behaviour-in-children-and-adolescents-a-review-of-quality-features-and-behaviour-change-techniques
#8
Stephanie Schoeppe, Stephanie Alley, Amanda L Rebar, Melanie Hayman, Nicola A Bray, Wendy Van Lippevelde, Jens-Peter Gnam, Philip Bachert, Artur Direito, Corneel Vandelanotte
BACKGROUND: The number of commercial apps to improve health behaviours in children is growing rapidly. While this provides opportunities for promoting health, the content and quality of apps targeting children and adolescents is largely unexplored. This review systematically evaluated the content and quality of apps to improve diet, physical activity and sedentary behaviour in children and adolescents, and examined relationships of app quality ratings with number of app features and behaviour change techniques (BCTs) used...
June 24, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28639310/high-resolution-31-p-echo-planar-spectroscopic-imaging-in-vivo-at-7t
#9
Andreas Korzowski, Peter Bachert
PURPOSE: Conventional (31) P chemical shift imaging is time-consuming and yields only limited spatial resolution. The purpose of this study was to demonstrate feasibility of (31) P echo-planar spectroscopic imaging (EPSI) in vivo at 7T. METHODS: A 3D (31) P EPSI sequence with trapezoidal-shaped gradient pulses was implemented on a 7T MR scanner. To increase spectral width with reduced demand on gradient performance, a multishot approach was chosen. Acquisition weighting and (31) P-{(1) H} double resonance for nuclear Overhauser signal enhancement were applied to increase sensitivity...
June 21, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28628422/t1%C3%AF-weighted-dynamic-glucose-enhanced-mr-imaging-in-the-human-brain
#10
Daniel Paech, Patrick Schuenke, Christina Koehler, Johannes Windschuh, Sibu Mundiyanapurath, Sebastian Bickelhaupt, David Bonekamp, Philipp Bäumer, Peter Bachert, Mark E Ladd, Martin Bendszus, Wolfgang Wick, Andreas Unterberg, Heinz-Peter Schlemmer, Moritz Zaiss, Alexander Radbruch
Purpose To evaluate the ability to detect intracerebral regions of increased glucose concentration at T1ρ-weighted dynamic glucose-enhanced (DGE) magnetic resonance (MR) imaging at 7.0 T. Materials and Methods This prospective study was approved by the institutional review board. Nine patients with newly diagnosed glioblastoma and four healthy volunteers were included in this study from October 2015 to July 2016. Adiabatically prepared chemical exchange-sensitive spin-lock imaging was performed with a 7.0-T whole-body unit with a temporal resolution of approximately 7 seconds, yielding the time-resolved DGE contrast...
June 16, 2017: Radiology
https://www.readbyqxmd.com/read/28621247/-aria-2016-executive-summary-integrated-care-pathways-for-predictive-medicine-across-the-life-cycle
#11
Ayşe Arzu Yorgancıoğlu, Ömer Kalaycı, Cemal Cingi, Bilun Gemicioğlu, Ali Fuat Kalyoncu, Iogana Agache, Claus Bachert, Anna Bedbrook, George Walter Canonica, Thomas Casale, Alvaro Cruz, Wytsk Ej Fokkens, Peter Hellings, Boleslaw Samolinski, Jean Bousquet
The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization (WHO) workshop in 1999. The initial goals were (i) to propose a new allergic rhinitis classification, (ii) to promote the concept of multi-morbidity in asthma and rhinitis and (iii) to develop guidelines with all stakeholders for global use in all countries and populations. ARIA- disseminated and implemented in over 70 countries globally- is now focusing on the implementation of emerging technologies for individualized and predictive medicine...
March 2017: Tüberküloz Ve Toraks
https://www.readbyqxmd.com/read/28602936/allergic-rhinitis-and-its-impact-on-asthma-aria-guidelines-2016-revision
#12
Jan L Brożek, Jean Bousquet, Ioana Agache, Arnav Agarwal, Claus Bachert, Sinthia Bosnic-Anticevich, Romina Brignardello-Petersen, G Walter Canonica, Thomas Casale, Niels H Chavannes, Jaime Correia de Sousa, Alvaro A Cruz, Carlos A Cuello-Garcia, Pascal Demoly, Mark Dykewicz, Itziar Etxeandia-Ikobaltzeta, Ivan D Florez, Wytske Fokkens, Joao Fonseca, Peter W Hellings, Ludger Klimek, Sergio Kowalski, Piotr Kuna, Kaja-Triin Laisaar, Désirée E Larenas-Linnemann, Karin C Lødrup Carlsen, Peter J Manning, Eli Meltzer, Joaquim Mullol, Antonella Muraro, Robyn O'Hehir, Ken Ohta, Petr Panzner, Nikolaos Papadopoulos, Hae-Sim Park, Gianni Passalacqua, Ruby Pawankar, David Price, John J Riva, Yetiani Roldán, Dermot Ryan, Behnam Sadeghirad, Boleslaw Samolinski, Peter Schmid-Grendelmeier, Aziz Sheikh, Alkis Togias, Antonio Valero, Arunas Valiulis, Erkka Valovirta, Matthew Ventresca, Dana Wallace, Susan Waserman, Magnus Wickman, Wojtek Wiercioch, Juan José Yepes-Nuñez, Luo Zhang, Yuan Zhang, Mihaela Zidarn, Torsten Zuberbier, Holger J Schünemann
BACKGROUND: Allergic rhinitis affects 10 to 40% of the population. It reduces quality of life, school and work performance, and is a frequent reason for office visits in general practice. Medical costs are large but avoidable costs associated with lost work productivity are even larger than those incurred by asthma. New evidence has accumulated since the last revision of the Allergic Rhinitis and its Impact on Asthma - ARIA guidelines in 2010 prompting its update. OBJECTIVE: To provide a targeted update of the ARIA guidelines...
June 8, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28600902/transfer-of-innovation-on-allergic-rhinitis-and-asthma-multimorbidity-in-the-elderly-macvia-aria-reference-site-twinning-eip-on-aha
#13
J Bousquet, I Agache, M R Aliberti, R Angles, I Annesi-Maesano, J M Anto, S Arnavielhe, E Asayag, E Bacci, A Bedbrook, C Bachert, I Baroni, B A Barreto, M Bedolla-Barajas, K C Bergmann, L Bertorello, M Bewick, T Bieber, S Birov, C Bindslev-Jensen, A Blua, M Bochenska Marciniak, I Bogus-Buczynska, S Bosnic-Anticevich, I Bosse, R Bourret, C Bucca, R Buonaiuto, D Caiazza, D Caillot, D P Caimmi, P Camargos, G Canfora, V Cardona, A M Carriazo, C Cartier, G Castellano, N H Chavannes, M M Ciaravolo, C Cingi, A Ciceran, L Colas, E Colgan, J Coll, D Conforti, J Correira de Sousa, R M Cortés-Grimaldo, F Corti, E Costa, A L Courbis, E Cousein, A A Cruz, A Custovic, B Cvetkovski, C Dario, M da Silva, Y Dauvilliers, F De Blay, T Dedeu, G De Feo, B De Martino, P Demoly, G De Vries, S Di Capua Ercolano, N Di Carluccio, M Doulapsi, G Dray, R Dubakiene, E Eller, R Emuzyte, J M Espinoza-Contreras, A Estrada-Cardona, J Farrell, J Ferrero, W J Fokkens, J Fonseca, J F Fontaine, S Forti, J L Gálvez-Romero, C I García-Cobas, M H Garcia Cruz, B Gemicioğlu, R Gerth van Wijk, M Guidacci, J Gómez-Vera, N A Guldemond, Z Gutter, T Haahtela, J Hajjam, P W Hellings, L Hernández-Velázquez, M Illario, J C Ivancevich, E Jares, G Joos, J Just, O Kalayci, A F Kalyoncu, J Karjalainen, T Keil, N Khaltaev, L Klimek, V Kritikos, I Kull, P Kuna, V Kvedariene, V Kolek, E Krzych-Fałta, M Kupczyk, P Lacwik, D Larenas-Linnemann, D Laune, D Lauri, J Lavrut, M Lessa, G Levato, L Lewis, I Lieten, A Lipiec, R Louis, J A Luna-Pech, A Magnan, J Malva, J F Maspero, J J Matta-Campos, O Mayora, M A Medina-Ávalos, E Melén, E Menditto, J Millot-Keurinck, G Moda, M Morais-Almeida, R Mösges, A Mota-Pinto, J Mullol, A Muraro, R Murray, M Noguès, M Nalin, L Napoli, H Neffen, R E O'Hehir, G Onorato, S Palkonen, N G Papadopoulos, G Passalacqua, J L Pépin, A M Pereira, M Persico, O Pfaar, A C Pozzi, E Prokopakis, F Raciborski, J Rimmer, J A Rizzo, C Robalo-Cordeiro, M Rodríguez-González, G Rolla, R E Roller-Wirnsberger, A Romano, M Romano, J Salimäki, B Samolinski, F S Serpa, S Shamai, M Sierra, M Sova, M Sorlini, C Stellato, R Stelmach, T Strandberg, V Stroetmann, R Stukas, A Szylling, R Tan, V Tibaldi, A Todo-Bom, S Toppila-Salmi, P Tomazic, U Trama, M Triggiani, A Valero, E Valovirta, A Valiulis, M van Eerd, T Vasankari, A Vatrella, M T Ventura, M T Verissimo, F Viart, S Williams, M Wagenmann, C Wanscher, M Westman, M Wickman, I Young, A Yorgancioglu, E Zernotti, T Zurbierber, A Zurkuhlen, B De Oliviera, A Senn
The overarching goals of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) are to enable European citizens to lead healthy, active and independent lives while ageing. The EIP on AHA includes 74 Reference Sites. The aim of this study is to transfer innovation from an App developed by the MACVIA-France EIP on AHA reference site (Allergy Diary) to other reference sites. The phenotypic characteristics of rhinitis and asthma multimorbidity in adults and the elderly will be compared using validated information and communication technology (ICT) tools (i...
June 10, 2017: Allergy
https://www.readbyqxmd.com/read/28572918/multi-morbidities-of-allergic-rhinitis-in-adults-european-academy-of-allergy-and-clinical-immunology-task-force-report
#14
REVIEW
C Cingi, P Gevaert, R Mösges, C Rondon, V Hox, M Rudenko, N B Muluk, G Scadding, F Manole, C Hupin, W J Fokkens, C Akdis, C Bachert, P Demoly, J Mullol, A Muraro, N Papadopoulos, R Pawankar, P Rombaux, E Toskala, L Kalogjera, E Prokopakis, P W Hellings, J Bousquet
This report has been prepared by the European Academy of Allergy and Clinical Immunology Task Force on Allergic Rhinitis (AR) comorbidities. The aim of this multidisciplinary European consensus document is to highlight the role of multimorbidities in the definition, classification, mechanisms, recommendations for diagnosis and treatment of AR, and to define the needs in this neglected area by a literature review. AR is a systemic allergic disease and is generally associated with numerous multi-morbid disorders, including asthma, eczema, food allergies, eosinophilic oesophagitis (EoE), conjunctivitis, chronic middle ear effusions, rhinosinusitis, adenoid hypertrophy, olfaction disorders, obstructive sleep apnea, disordered sleep and consequent behavioural and educational effects...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28550649/improved-formula-see-text-determination-in-23-na-35-cl-and-17-o-mri-using-iterative-partial-volume-correction-based-on-1-h-mri-segmentation
#15
Sebastian C Niesporek, Reiner Umathum, Thomas M Fiedler, Peter Bachert, Mark E Ladd, Armin M Nagel
OBJECTIVE: Functional parameters can be measured with the help of quantitative non-proton MRI where exact relaxometry parameters are needed. Investigation of [Formula: see text] is often biased by strong partial volume (PV) effects. Hence, in this work a PV correction algorithm approach was evaluated that uses iteratively adapted [Formula: see text]-values and high-resolution structural (1)H data to determine transverse relaxation in non-proton MRI more accurately. MATERIALS AND METHODS: Simulations, a phantom study and in vivo (23)Na, (17)O and (35)Cl MRI measurements of five healthy volunteers were performed to evaluate the algorithm...
May 26, 2017: Magma
https://www.readbyqxmd.com/read/28532656/the-il-33-st2-axis-is-crucial-in-type-2-airway-responses-induced-by-the-staphylococcus-aureus-protease-spld
#16
Andrea R Teufelberger, Maria Nordengrün, Harald Braun, Tania Maes, Katrien De Grove, Gabriele Holtappels, Clara O'Brien, Sharen Provoost, Hamida Hammad, Amanda Gonçalves, Rudi Beyaert, Wim Declercq, Peter Vandenabeele, Dmitri V Krysko, Barbara M Bröker, Claus Bachert, Olga Krysko
BACKGROUND: Chronic airway inflammatory diseases such as chronic rhinosinusitis with nasal polyps and asthma showed increased nasal Staphylococcus aureus (S. aureus) colonization. Serine protease like protein D (SplD) and other closely related proteases secreted by S. aureus have recently been identified as inducers of allergic asthma in humans and mice but their mechanism of action is largely unknown. OBJECTIVE: We investigated the role of recombinant SplD in driving Th2-biased responses and IgE formation in a murine model of allergic asthma...
May 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28526278/biotherapeutics-in-chronic-rhinosinusitis-with-and-without-nasal-polyps
#17
Claus Bachert, Philippe Gevaert, Peter Hellings
In western countries, 85% of chronic rhinosinusitis with nasal polyp disease reveals a type 2 inflammatory pattern with expression of IL-4, -5, and -13 as well as increased concentrations of IgE, whereas chronic rhinosinusitis without nasal polyps merely expresses these biomarkers. The degree of type 2 inflammation furthermore is associated with disease severity, asthma comorbidity, and recurrence of disease after surgery. Therefore, these biomarkers also form the targets for innovative therapeutic approaches such as monoclonal antibodies directed against IgE, IL-5, and IL-4 receptor alpha, blocking the activity of IL-4 and -13...
May 16, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28501885/euforea-rhinology-research-forum-2016-report-of-the-brainstorming-sessions-on-needs-and-priorities-in-rhinitis-and-rhinosinusitis
#18
P W Hellings, C A Akdis, C Bachert, J Bousquet, B Pugin, G Adriaensen, R Advani, I Agache, C Anjo, R Anmolsingh, E Annoni, T Bieber, A Bizaki, I Braverman, I Callebaut, J A Castillo Vizuete, T Chalermwatanachai, R Chmielewski, C Cingi, L Cools, C Coppije, M E Cornet, I De Boeck, E De Corso, G De Greve, M Doulaptsi, R Edmiston, S Erskine, E Gevaert, P Gevaert, K Golebski, C Hopkins, V Hox, C Jaeggi, G Joos, S Khwaja, A Kjeldsen, L Klimek, M Koennecke, I Kortekaas Krohn, O Krysko, B N Kumar, C Langdon, B Lange, G Lekakis, P Levie, E Lourijsen, V J Lund, K Martens, R Mösges, J Mullol, T D Nyembue, S Palkonen, C Philpott, J Pimentel, A Poirrier, A C Pratas, E Prokopakis, L Pujols, P Rombaux, C Schmidt-Weber, C Segboer, I Spacova, J Staikuniene, B Steelant, E A Steinsvik, A Teufelberger, L Van Gerven, K Van Gool, R Verbrugge, B Verhaeghe, P Virkkula, S Vlaminck, E Vries-Uss, M Wagenmann, T Zuberbier, S F Seys, W J Fokkens
The first European Rhinology Research Forum organized by the European Forum for Research and Education in Allergy and Airway Diseases (EUFOREA) was held in the Royal Academy of Medicine in Brussels on 17th and 18th November 2016, in collaboration with the European Rhinologic Society (ERS) and the Global Allergy and Asthma European Network (GA2LEN). One hundred and thirty participants (medical doctors from different specialties, researchers, as well as patients and industry representatives) from 27 countries took part in the multiple perspective discussions including brainstorming sessions on care pathways and research needs in rhinitis and rhinosinusitis...
May 14, 2017: Rhinology
https://www.readbyqxmd.com/read/28501884/the-effect-of-systemic-treatments-on-periostin-expression-reflects-their-interference-with-the-eosinophilic-inflammation-in-chronic-rhinosinusitis-with-nasal-polyps
#19
E De Schryver, L Derycke, L Calus, G Holtappels, P W Hellings, T Van Zele, C Bachert, P Gevaert
BACKGROUND: Periostin is a recently discovered biomarker for eosinophilic inflammation. Chronic rhinosinusitis with nasal polyps is a T-helper 2-skewed chronic inflammatory airway disease. Medical treatments aim to relieve symptoms and maintain clinical control by interfering with the inflammatory cascade. The effect on nasal and serum periostin levels is however yet unknown. We aimed to evaluate the effect of omalizumab, mepolizumab, methylprednisolone and doxycycline on nasal and systemic periostin expression...
June 1, 2017: Rhinology
https://www.readbyqxmd.com/read/28474799/non-allergic-rhinitis-position-paper-of-the-european-academy-of-allergology-and-clinical-immunology
#20
P W Hellings, L Klimek, C Cingi, I Agache, C Akdis, C Bachert, J Bousquet, P Demoly, P Gevaert, V Hox, C Hupin, L Kalogjera, F Manole, R Mösges, J Mullol, N B Muluk, A Muraro, N Papadopoulos, R Pawankar, C Rondon, M Rundenko, S F Seys, E Toskala, L Van Gerven, L Zhang, N Zhang, W J Fokkens
This EAACI position paper aims at providing a state-of-the-art overview on non-allergic rhinitis (NAR). A significant number of patients suffering from persistent rhinitis are defined as non-allergic non-infectious rhinitis (NANIR) patients, often denominated in short as having NAR. NAR is defined as a symptomatic inflammation of the nasal mucosa with the presence of minimal 2 nasal symptoms like nasal obstruction, rhinorrhoea, sneezing, and/or itchy nose, without clinical evidence of endonasal infection and without systemic signs of sensitization to inhalant allergens...
May 5, 2017: Allergy
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