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Els De Schryver, Lara Derycke, Paloma Campo, Eline Gabriels, Guy F Joos, Thibaut Van Zele, Claus Bachert, Peter W Hellings, Philippe Gevaert
BACKGROUND: An important percentage of subjects diagnosed with chronic upper airway disease report alcohol-induced worsening of their symptoms. The prevalence and characteristics of respiratory reactions provoked by alcohol-containing drinks has not been fully investigated yet. OBJECTIVE: The aim of this study was to estimate the prevalence and characteristics of alcohol hyper-responsiveness in patients with chronic airway disease and healthy controls. Furthermore, nasal inflammation was evaluated in nasal polyp patients with and without hyper-responsiveness...
October 22, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Torsten Zuberbier, Mark B Abelson, Cezmi A Akdis, Claus Bachert, Uwe Berger, Carsten Bindslev-Jensen, Georg Boelke, Jean Bousquet, Giorgio Walter Canonica, Thomas B Casale, Marek Jutel, Marek L Kowalski, Enzo Madonini, Nikolaos G Papadopoulos, Oliver Pfaar, Torsten Sehlinger, Karl-Christian Bergmann
BACKGROUND: Field clinical trials of pollen allergy are impacted by the impossibility to predict and to determine individual allergen exposure, due to many factors (e.g., pollen season, atmospheric variations, pollutants, lifestyles). Environmental exposure chambers (EEC), delivering a fixed amount of allergens in a controlled environmental setting, can overcome these limitations. EECs are currently already used in phase 2, 3, and even 4 trials. Unfortunately, few chambers exist in the world, and this makes it difficult to perform large, multicenter clinical trials...
September 30, 2016: Journal of Allergy and Clinical Immunology
G van Kaick, P Bachert
No abstract text is available yet for this article.
September 30, 2016: Der Radiologe
Lina Song, Collin Bachert, Adam D Linstedt
Mucin-type O-glycosylation occurring in the Golgi apparatus is an important protein posttranslational modification initiated by up to 20 GalNAc-transferase isozymes with largely distinct substrate specificities. Regulation of this enzyme family affects a vast array of proteins transiting the secretory pathway and misregulation causes human diseases. Here we describe the use of protein-based fluorescence sensors that traffic in the secretory pathway to monitor GalNAc-transferase activity in living cells. The sensors can either be "pan" or isozyme specific...
2016: Methods in Molecular Biology
Beth A Bachert, Soo J Choi, Paul R LaSala, Tiffany I Harper, Dudley H McNitt, Dylan T Boehm, Clayton C Caswell, Pawel Ciborowski, Douglas R Keene, Anthony R Flores, James M Musser, Flavia Squeglia, Daniela Marasco, Rita Berisio, Slawomir Lukomski
The streptococcal collagen-like proteins 1 and 2 (Scl1 and Scl2) are major surface adhesins that are ubiquitous among group A Streptococcus (GAS). Invasive M3-type strains, however, have evolved two unique conserved features in the scl1 locus: (i) an IS1548 element insertion in the scl1 promoter region and (ii) a nonsense mutation within the scl1 coding sequence. The scl1 transcript is drastically reduced in M3-type GAS, contrasting with a high transcription level of scl1 allele in invasive M1-type GAS. This leads to a lack of Scl1 expression in M3 strains...
2016: Frontiers in Cellular and Infection Microbiology
Peter Vandenabeele, Katrien Vandecasteele, Claus Bachert, Olga Krysko, Dmitri V Krysko
For many years it has been thought that apoptotic cells rapidly cleared by phagocytic cells do not trigger an immune response but rather have anti-inflammatory properties. However, accumulating experimental data indicate that certain anticancer therapies can induce an immunogenic form of apoptosis associated with the emission of damage-associated molecular patterns (DAMPs), which function as adjuvants to activate host antitumor immune responses. In this review, we will first discuss recent advances and the significance of danger signaling pathways involved in the emission of DAMPs, including calreticulin, ATP, and HMGB1...
2016: Advances in Experimental Medicine and Biology
Xiangdong Wang, Nan Zhang, Mingyu Bo Ms, Gabriele Holtappels, Ming Zheng, Hongfei Lou, Hong Wang, Luo Zhang, Claus Bachert
BACKGROUND: To date, no study has evaluated the diversity of TH cell cytokine patterns of patients with chronic rhinosinusitis (CRS) among centers in different continents using identical methods. OBJECTIVE: We sought to assess TH cytokine profiles in patients with CRS from Europe, Asia, and Australia. METHODS: Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP; n = 435) and control subjects (n = 138) were recruited from centers in Adelaide, Benelux, Berlin, Beijing, Chengdu, and Tochigi...
July 15, 2016: Journal of Allergy and Clinical Immunology
Patrick Schuenke, Christina Koehler, Andreas Korzowski, Johannes Windschuh, Peter Bachert, Mark E Ladd, Sibu Mundiyanapurath, Daniel Paech, Sebastian Bickelhaupt, David Bonekamp, Heinz-Peter Schlemmer, Alexander Radbruch, Moritz Zaiss
PURPOSE: Chemical exchange sensitive spin-lock and related techniques allow to observe the uptake of administered D-glucose in vivo. The exchange-weighting increases with the magnetic field strength, but inhomogeneities in the radiofrequency (RF) field at ultrahigh field whole-body scanners lead to artifacts in conventional spin-lock experiments. Thus, our aim was the development of an adiabatically prepared T1ρ -based imaging sequence applicable to studies of glucose metabolism in tumor patients at ultrahigh field strengths...
August 13, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Vanesa González-Núñez, Claus Bachert, Joaquim Mullol
INTRODUCTION: Rupatadine is a second-generation H1-antihistamine with dual affinity for histamine H1 and PAF receptors. Rupatadine is indicated for the treatment of allergic rhinitis and urticaria. AREAS COVERED: A Medline search was conducted to identify preclinical and clinical studies of rupatadine. This was supplemented with additional articles obtained from online sources. The focus of this review is on the safety profile of rupatadine. EXPERT OPINION: The review of these data indicates that rupatadine is highly selective for histamine H1-receptors, exhibits additional PAF antagonism in in vitro and in vivo studies, does not cross the blood-brain barrier, and has similar adverse events comparable with other second-generation antihistamines...
October 2016: Expert Opinion on Drug Safety
J Bousquet, J Farrell, G Crooks, P Hellings, E H Bel, M Bewick, N H Chavannes, J Correia de Sousa, A A Cruz, T Haahtela, G Joos, N Khaltaev, J Malva, A Muraro, M Nogues, S Palkonen, S Pedersen, C Robalo-Cordeiro, B Samolinski, T Strandberg, A Valiulis, A Yorgancioglu, T Zuberbier, A Bedbrook, W Aberer, M Adachi, A Agusti, C A Akdis, M Akdis, J Ankri, A Alonso, I Annesi-Maesano, I J Ansotegui, J M Anto, S Arnavielhe, H Arshad, C Bai, I Baiardini, C Bachert, A K Baigenzhin, C Barbara, E D Bateman, B Beghé, A Ben Kheder, K S Bennoor, M Benson, K C Bergmann, T Bieber, C Bindslev-Jensen, L Bjermer, H Blain, F Blasi, A L Boner, M Bonini, S Bonini, S Bosnic-Anticevitch, L P Boulet, R Bourret, P J Bousquet, F Braido, A H Briggs, C E Brightling, J Brozek, R Buhl, P G Burney, A Bush, F Caballero-Fonseca, D Caimmi, M A Calderon, P M Calverley, P A M Camargos, G W Canonica, T Camuzat, K H Carlsen, W Carr, A Carriazo, T Casale, A M Cepeda Sarabia, L Chatzi, Y Z Chen, R Chiron, E Chkhartishvili, A G Chuchalin, K F Chung, G Ciprandi, I Cirule, L Cox, D J Costa, A Custovic, R Dahl, S E Dahlen, U Darsow, G De Carlo, F De Blay, T Dedeu, D Deleanu, E De Manuel Keenoy, P Demoly, J A Denburg, P Devillier, A Didier, A T Dinh-Xuan, R Djukanovic, D Dokic, H Douagui, G Dray, R Dubakiene, S R Durham, M S Dykewicz, Y El-Gamal, R Emuzyte, L M Fabbri, M Fletcher, A Fiocchi, A Fink Wagner, J Fonseca, W J Fokkens, F Forastiere, P Frith, M Gaga, A Gamkrelidze, J Garces, J Garcia-Aymerich, B Gemicioğlu, J E Gereda, S González Diaz, M Gotua, I Grisle, L Grouse, Z Gutter, M A Guzmán, L G Heaney, B Hellquist-Dahl, D Henderson, A Hendry, J Heinrich, D Heve, F Horak, J O' B Hourihane, P Howarth, M Humbert, M E Hyland, M Illario, J C Ivancevich, J R Jardim, E J Jares, C Jeandel, C Jenkins, S L Johnston, O Jonquet, K Julge, K S Jung, J Just, I Kaidashev, M R Kaitov, O Kalayci, A F Kalyoncu, T Keil, P K Keith, L Klimek, B Koffi N'Goran, V Kolek, G H Koppelman, M L Kowalski, I Kull, P Kuna, V Kvedariene, B Lambrecht, S Lau, D Larenas-Linnemann, D Laune, L T T Le, P Lieberman, B Lipworth, J Li, K Lodrup Carlsen, R Louis, W MacNee, Y Magard, A Magnan, B Mahboub, A Mair, I Majer, M J Makela, P Manning, S Mara, G D Marshall, M R Masjedi, P Matignon, M Maurer, S Mavale-Manuel, E Melén, E Melo-Gomes, E O Meltzer, A Menzies-Gow, H Merk, J P Michel, N Miculinic, F Mihaltan, B Milenkovic, G M Y Mohammad, M Molimard, I Momas, A Montilla-Santana, M Morais-Almeida, M Morgan, R Mösges, J Mullol, S Nafti, L Namazova-Baranova, R Naclerio, A Neou, H Neffen, K Nekam, B Niggemann, G Ninot, T D Nyembue, R E O'Hehir, K Ohta, Y Okamoto, K Okubo, S Ouedraogo, P Paggiaro, I Pali-Schöll, P Panzner, N Papadopoulos, A Papi, H S Park, G Passalacqua, I Pavord, R Pawankar, R Pengelly, O Pfaar, R Picard, B Pigearias, I Pin, D Plavec, D Poethig, W Pohl, T A Popov, F Portejoie, P Potter, D Postma, D Price, K F Rabe, F Raciborski, F Radier Pontal, S Repka-Ramirez, S Reitamo, S Rennard, F Rodenas, J Roberts, J Roca, L Rodriguez Mañas, C Rolland, M Roman Rodriguez, A Romano, J Rosado-Pinto, N Rosario, L Rosenwasser, M Rottem, D Ryan, M Sanchez-Borges, G K Scadding, H J Schunemann, E Serrano, P Schmid-Grendelmeier, H Schulz, A Sheikh, M Shields, N Siafakas, Y Sibille, T Similowski, F E R Simons, J C Sisul, I Skrindo, H A Smit, D Solé, T Sooronbaev, O Spranger, R Stelmach, P J Sterk, J Sunyer, C Thijs, T To, A Todo-Bom, M Triggiani, R Valenta, A L Valero, E Valia, E Valovirta, E Van Ganse, M van Hage, O Vandenplas, T Vasankari, B Vellas, J Vestbo, G Vezzani, P Vichyanond, G Viegi, C Vogelmeier, T Vontetsianos, M Wagenmann, B Wallaert, S Walker, D Y Wang, U Wahn, M Wickman, D M Williams, S Williams, J Wright, B P Yawn, P K Yiallouros, O M Yusuf, A Zaidi, H J Zar, M E Zernotti, L Zhang, N Zhong, M Zidarn, J Mercier
Action Plan B3 of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) focuses on the integrated care of chronic diseases. Area 5 (Care Pathways) was initiated using chronic respiratory diseases as a model. The chronic respiratory disease action plan includes (1) AIRWAYS integrated care pathways (ICPs), (2) the joint initiative between the Reference site MACVIA-LR (Contre les MAladies Chroniques pour un VIeillissement Actif) and ARIA (Allergic Rhinitis and its Impact on Asthma), (3) Commitments for Action to the European Innovation Partnership on Active and Healthy Ageing and the AIRWAYS ICPs network...
2016: Clinical and Translational Allergy
Vanessa Stahl, Florian Maier, Martin T Freitag, Ralf O Floca, Moritz C Berger, Reiner Umathum, Mauricio Berriel Diaz, Stephan Herzig, Marc-André Weber, Antonia Dimitrakopoulou-Strauss, Kristian Rink, Peter Bachert, Mark E Ladd, Armin M Nagel
PURPOSE: To evaluate the volume and changes of human brown adipose tissue (BAT) in vivo following exposure to cold using magnetic resonance imaging (MRI). MATERIALS AND METHODS: The clavicular region of 10 healthy volunteers was examined with a 3T MRI system. One volunteer participated twice. A cooling vest that was circulated with temperature-controlled water was used to expose each volunteer to a cold environment. Three different water temperature phases were employed: baseline (23°C, 20 min), cooling (12°C, 90 min), and a final warming phase (37°C, 30 min)...
July 15, 2016: Journal of Magnetic Resonance Imaging: JMRI
Seong H Cho, Claus Bachert, Richard F Lockey
No abstract text is available yet for this article.
July 2016: Journal of Allergy and Clinical Immunology in Practice
Claus Bachert, Cezmi A Akdis
Chronic rhinosinusitis can be differentiated into several phenotypes based on clinical criteria; however, these phenotypes do not teach us much about the underlying inflammatory mechanisms. Thus, the use of nasal endoscopy and CT scanning, and eventually taking a swab or a biopsy, may not be sufficient to fully appreciate the individual patient's pathology. Endotyping of chronic rhinosinusitis on the basis of pathomechanisms, functionally and pathologically different from others by the involvement of specific molecules or cells, may in contrast provide us with information on the risk of disease progression or recurrence and on the best available treatment, and also helps us identifying innovative therapeutic targets for treatment...
July 2016: Journal of Allergy and Clinical Immunology in Practice
Viktor Henmyr, Christina Lind-Halldén, Christer Halldén, Torbjörn Säll, Daniel Carlberg, Claus Bachert, Lars-Olaf Cardell
Genetic studies of chronic rhinosinusitis (CRS) have identified a total of 53 CRS-associated SNPs that were subsequently evaluated for their reproducibility in a recent study. The rs2873551 SNP in linkage disequilibrium with PARS2 showed the strongest association signal. The present study aims to comprehensively screen for rare variants in PARS2 and evaluate for accumulation of such variants in CRS-patients. Sanger sequencing and long-range PCR were used to screen for rare variants in the putative promoter region and coding sequence of 310 CRS-patients and a total of 21 variants were detected...
2016: PloS One
David B Price, Glenis Scadding, Claus Bachert, Hesham Saleh, Shuaib Nasser, Victoria Carter, Julie von Ziegenweidt, Alice M S Durieux, Dermot Ryan
Little data on UK prescribing patterns and treatment effectiveness for allergic rhinitis (AR) are available. We quantified unmet pharmacologic needs in AR by assessing AR treatment effectiveness based on the prescribing behaviour of UK general practitioners (GP) during two consecutive pollen seasons (2009 and 2010). We conducted a retrospective observational study with the data from the Optimum Patient Care Research Database. We assessed diagnoses and prescription data for patients with a recorded diagnosis of rhinitis who took rhinitis medication during the study period...
2016: NPJ Primary Care Respiratory Medicine
Sebastian Stentzel, Andrea Teufelberger, Maria Nordengrün, Julia Kolata, Frank Schmidt, Koen van Crombruggen, Stephan Michalik, Jana Kumpfmüller, Sebastian Tischer, Thomas Schweder, Michael Hecker, Susanne Engelmann, Uwe Völker, Olga Krysko, Claus Bachert, Barbara M Bröker
BACKGROUND: A substantial subgroup of asthmatic patients have "nonallergic" or idiopathic asthma, which often takes a severe course and is difficult to treat. The cause might be allergic reactions to the gram-positive pathogen Staphylococcus aureus, a frequent colonizer of the upper airways. However, the driving allergens of S aureus have remained elusive. OBJECTIVE: We sought to search for potentially allergenic S aureus proteins and characterize the immune response directed against them...
May 10, 2016: Journal of Allergy and Clinical Immunology
Els De Schryver, Lien Calus, Henryk Bonte, De Ruyck Natalie, Hannah Gould, Erin Donovan, Dirk Elewaut, Rudolf Valenta, Irene Mittermann, Jan Gutermuth, Tanja Seher, Robert P Schleimer, Bruce K Tan, Lara Derycke, Thibaut Van Zele, Claus Bachert, Philippe Gevaert
No abstract text is available yet for this article.
September 2016: Journal of Allergy and Clinical Immunology
Jean Bousquet, Holger J Schünemann, Peter W Hellings, Sylvie Arnavielhe, Claus Bachert, Anna Bedbrook, Karl-Christian Bergmann, Sinthia Bosnic-Anticevich, Jan Brozek, Moises Calderon, G Walter Canonica, Thomas B Casale, Niels H Chavannes, Linda Cox, Henry Chrystyn, Alvaro A Cruz, Ronald Dahl, Giuseppe De Carlo, Pascal Demoly, Phillipe Devillier, Gérard Dray, Monica Fletcher, Wytske J Fokkens, Joao Fonseca, Sandra N Gonzalez-Diaz, Lawrence Grouse, Thomas Keil, Piotr Kuna, Désirée Larenas-Linnemann, Karin C Lodrup Carlsen, Eli O Meltzer, Jaoquim Mullol, Antonella Muraro, Robert N Naclerio, Susanna Palkonen, Nikolaos G Papadopoulos, Giovanni Passalacqua, David Price, Dermot Ryan, Boleslaw Samolinski, Glenis K Scadding, Aziz Sheikh, François Spertini, Arunas Valiulis, Erkka Valovirta, Samantha Walker, Magnus Wickman, Arzu Yorgancioglu, Tari Haahtela, Torsten Zuberbier
The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity, control of AR, patient preferences, and cost. Allergen exposure and the resulting symptoms vary, and treatment adjustment is required. Clinical decision support systems (CDSSs) might be beneficial for the assessment of disease control. CDSSs should be based on the best evidence and algorithms to aid patients and health care professionals to jointly determine treatment and its step-up or step-down strategy depending on AR control...
August 2016: Journal of Allergy and Clinical Immunology
J S Makowska, P Burney, D Jarvis, T Keil, P Tomassen, J Bislimovska, G Brozek, C Bachert, J Baelum, C Bindslev-Jensen, J Bousquet, P J Bousquet, C Kai-Håkon, S E Dahlen, B Dahlen, W J Fokkens, B Forsberg, M Gjomarkaj, P Howarth, E Salagean, C Janson, L Kasper, U Kraemer, C Louiro, B Lundback, J Minov, E Nizankowska-Mogilnicka, N Papadopoulos, A G Sakellariou, A Todo-Bom, E Toskala, J E Zejda, T Zuberbier, M L Kowalski
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most prevalent drugs inducing hypersensitivity reactions. The aim of this analysis was to estimate the prevalence of NSAID-induced respiratory symptoms in population across Europe and to assess its association with upper and lower respiratory tract disorders. METHODS: The GA(2) LEN survey was conducted in 22 centers in 15 European countries. Each of 19 centers selected random samples of 5000 adults aged 15-74 from their general population, and in three centers (Athens, Munich, Oslo), a younger population was sampled...
May 27, 2016: Allergy
F Lan, N Zhang, E Gevaert, L Zhang, C Bachert
Allergic airway diseases are typically characterized by a type 2-biased inflammation. Multiple distinct viruses and bacteria have been detected in the airways. Recently, it has been confirmed that the microbiome of allergic individuals differs from that of healthy subjects, showing a close relationship with the type 2 response in allergic airway disease. In this review, we summarize the recent findings on the prevalence of viruses and bacteria in type 2-biased airway diseases and on the mechanisms employed by viruses and bacteria in propagating type 2 responses...
October 2016: Allergy
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