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https://www.readbyqxmd.com/read/28183433/mechanisms-of-the-development-of-allergy-medall-introducing-novel-concepts-in-allergy-phenotypes
#1
REVIEW
Josep M Anto, Jean Bousquet, Mubeccel Akdis, Charles Auffray, Thomas Keil, Isabelle Momas, Dirkje S Postma, Rudolf Valenta, Magnus Wickman, Anne Cambon-Thomsen, Tari Haahtela, Bart N Lambrecht, Karin C Lodrup Carlsen, Gerard H Koppelman, Jordi Sunyer, Torsten Zuberbier, Isabelle Annesi-Maesano, Albert Arno, Carsten Bindslev-Jensen, Giuseppe De Carlo, Francesco Forastiere, Joachim Heinrich, Marek L Kowalski, Dieter Maier, Erik Melén, Henriette A Smit, Marie Standl, John Wright, Anna Asarnoj, Marta Benet, Natalia Ballardini, Judith Garcia-Aymerich, Ulrike Gehring, Stefano Guerra, Cynthia Hohmann, Inger Kull, Christian Lupinek, Mariona Pinart, Ingebjorg Skrindo, Marit Westman, Delphine Smagghe, Cezmi Akdis, Niklas Andersson, Claus Bachert, Stephane Ballereau, Ferran Ballester, Xavier Basagana, Anna Bedbrook, Anna Bergstrom, Andrea von Berg, Bert Brunekreef, Emilie Burte, Kai-Hakon Carlsen, Leda Chatzi, Jonathan M Coquet, Mirela Curin, Pascal Demoly, Esben Eller, Maria Pia Fantini, Leena von Hertzen, Vergard Hovland, Benedicte Jacquemin, Jocelyne Just, Theresa Keller, Renata Kiss, Manolis Kogevinas, Sibylle Koletzko, Susanne Lau, Irina Lehmann, Nicolas Lemonnier, Mika Mäkelä, Jordi Mestres, Peter Mowinckel, Rachel Nadif, Martijn C Nawijn, Johan Pellet, Isabelle Pin, Daniela Porta, Fanny Rancière, Emmanuelle Rial-Sebbag, Yvan Saeys, Martijn J Schuijs, Valerie Siroux, Christina G Tischer, Mathies Torrent, Raphaelle Varraso, Kalus Wenzel, Cheng-Jian Xu
Asthma, rhinitis, and eczema are complex diseases with multiple genetic and environmental factors interlinked through IgE-associated and non-IgE-associated mechanisms. Mechanisms of the Development of ALLergy (MeDALL; EU FP7-CP-IP; project no: 261357; 2010-2015) studied the complex links of allergic diseases at the clinical and mechanistic levels by linking epidemiologic, clinical, and mechanistic research, including in vivo and in vitro models. MeDALL integrated 14 European birth cohorts, including 44,010 participants and 160 cohort follow-ups between pregnancy and age 20 years...
February 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28169369/fast-and-quantitative-t1%C3%AF-weighted-dynamic-glucose-enhanced-mri
#2
Patrick Schuenke, Daniel Paech, Christina Koehler, Johannes Windschuh, Peter Bachert, Mark E Ladd, Heinz-Peter Schlemmer, Alexander Radbruch, Moritz Zaiss
Common medical imaging techniques usually employ contrast agents that are chemically labeled, e.g. with radioisotopes in the case of PET, iodine in the case of CT or paramagnetic metals in the case of MRI to visualize the heterogeneity of the tumor microenvironment. Recently, it was shown that natural unlabeled D-glucose can be used as a nontoxic biodegradable contrast agent in Chemical Exchange sensitive Spin-Lock (CESL) magnetic resonance imaging (MRI) to detect the glucose uptake and potentially the metabolism of tumors...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28149501/is-fruit-and-vegetable-intake-associated-with-asthma-or-chronic-rhino-sinusitis-in-european-adults-results-from-the-global-allergy-and-asthma-network-of-excellence-ga-2-len-survey
#3
Vanessa Garcia-Larsen, Rhonda Arthur, James F Potts, Peter H Howarth, Matti Ahlström, Tari Haahtela, Carlos Loureiro, Ana Todo Bom, Grzegorz Brożek, Joanna Makowska, Marek L Kowalski, Trine Thilsing, Thomas Keil, Paolo M Matricardi, Kjell Torén, Thibaut van Zele, Claus Bachert, Barbara Rymarczyk, Christer Janson, Bertil Forsberg, Ewa Niżankowska-Mogilnicka, Peter G J Burney
BACKGROUND: Fruits and vegetables are rich in compounds with proposed antioxidant, anti-allergic and anti-inflammatory properties, which could contribute to reduce the prevalence of asthma and allergic diseases. OBJECTIVE: We investigated the association between asthma, and chronic rhino-sinusitis (CRS) with intake of fruits and vegetables in European adults. METHODS: A stratified random sample was drawn from the Global Allergy and Asthma Network of Excellence (GA(2)LEN) screening survey, in which 55,000 adults aged 15-75 answered a questionnaire on respiratory symptoms...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28140507/google-trends-terms-reporting-rhinitis-and-related-topics-differ-in-european-countries
#4
Jean Bousquet, Ioana Agache, Josep M Anto, Karl C Bergmann, Claus Bachert, Isabella Annesi-Maesano, Philippe J Bousquet, Gennaro D'Amato, Pascal Demoly, Govert De Vries, Esben Eller, Wytske Fokkens, Joao Fonseca, Tari Haahtela, Peter W Hellings, Jocelyne Just, Thomas Keil, Ludger Klimek, Piotr Kuna, Karin C Lodrup Carlsen, Ralf Mösges, Ruth Murray, Kristof Nekam, Gabrielle Onorato, Nikos G Papadopoulos, Boleslaw Samolinski, Peter Schmid-Grendelmeier, Michel Thibaudon, Peter Tomazic, Massimo Triggiani, Arunas Valiulis, Erkka Valovirta, Michiel Van Eerd, Magnus Wickman, Torsten Zuberbier, Aziz Sheikh
Google Trends (GT) searches trends of specific queries in Google and reflects the real-life epidemiology of allergic rhinitis. We compared Google Trends terms related to allergy and rhinitis in all European Union countries, Norway and Switzerland from January 1, 2011 to December 20, 2016. The aim was to assess whether the same terms could be used to report the seasonal variations of allergic diseases. Using the Google Trend 5-year graph, an annual and clear seasonality of queries was found in all countries apart from Cyprus, Estonia, Latvia, Lithuania and Malta...
January 31, 2017: Allergy
https://www.readbyqxmd.com/read/28131916/low-concentration-of-uncouplers-of-oxidative-phosphorylation-decreases-the-tnf-induced-endothelial-permeability-and-lethality-in-mice
#5
Vlada V Zakharova, Olga Yu Pletjushkina, Ivan I Galkin, Roman A Zinovkin, Boris V Chernyak, Dmitri V Krysko, Claus Bachert, Olga Krysko, Vladimir P Skulachev, Ekaterina N Popova
Mitochondrial dysfunctions occur in many diseases linked to the systemic inflammatory response syndrome (SIRS). Mild uncoupling of oxidative phosphorylation is known to rescue model animals from pathologies related to mitochondrial dysfunctions and overproduction of reactive oxygen species (ROS). To study the potential of SIRS therapy by uncoupling, we tested protonophore dinitrophenol (DNP) and a free fatty acid (FFA) anion carrier, lipophilic cation dodecyltriphenylphosphonium (C12TPP) in mice and in vitro models of SIRS...
January 26, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28122135/pd-1-expression-correlates-with-disease-severity-and-il-5-in-chronic-rhinosinusitis-with-nasal-polyps
#6
Inge Kortekaas Krohn, Sonja Bobic, James Dooley, Feng Lan, Nan Zhang, Claus Bachert, Brecht Steelant, Dominique Bullens, Adrian Liston, Jan L Ceuppens, Sven F Seys, Peter W Hellings
BACKGROUND: Programmed cell Death 1 (PD-1) is a negative regulator of T cell responses. Expression of PD-1 and its ligands PD-L1 and PD-L2 in chronic rhinosinusitis with nasal polyps (CRSwNP) is poorly studied. METHODS: Expression of PD-1, PD-L1, PD-L2, TGF-β, IL-5 and IL-10 mRNA was measured by RT-PCR on tissue homogenates of patients with CRSwNP (n=21) and healthy controls (n=21) and on primary epithelial cells. Disease severity was scored using the Lund-Mackay scores of maxillo-facial CT scans...
January 25, 2017: Allergy
https://www.readbyqxmd.com/read/28099884/characterization-of-human-and-staphylococcus-aureus-proteins-in-respiratory-mucosa-by-in-vivo-and-immunoproteomics
#7
Frank Schmidt, Tanja Meyer, Nandakumar Sundaramoorthy, Stephan Michalik, Kristin Surmann, Maren Depke, Vishnu Dhople, Manuela Gesell Salazar, Gabriele Holtappels, Nan Zhang, Barbara M Bröker, Claus Bachert, Uwe Völker
: Staphylococcus aureus is a Gram-positive opportunistic bacterium which can be found as a commensal in the nares of about 50% of the human population. Besides asymptomatic carriage, S. aureus has also been found to colonize nasal polyps, a subform of chronic rhinosinusitis, in 60 to 100% of cases, and even reside intracellularly in nasal polyp tissue. The aim of this study was to shed light on the behavior of S. aureus in the human airways by analyzing S. aureus-specific proteins in nasal polyp tissue from patients with chronic rhinosinusitis and to characterize the immunogenic potential of the identified (mainly secreted) proteins...
January 15, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28072463/pilot-study-of-mobile-phone-technology-in-allergic-rhinitis-in-european-countries-the-mask-rhinitis-study
#8
J Bousquet, D P Caimmi, A Bedbrook, M Bewick, P W Hellings, P Devillier, S Arnavielhe, C Bachert, K C Bergmann, G W Canonica, N Chavannes, A A Cruz, R Dahl, P Demoly, G De Vries, E Mathieu-Dupas, A Fink Wagner, J Fonseca, N Guldemond, T Haahtela, B Hellqvist-Dahl, J Just, T Keil, L Klimek, M L Kowalski, M Kuitunen, P Kuna, V Kvedariene, D Laune, A M Pereira, P Carreiro-Martins, E Melén, M Morais-Almeida, J Mullol, A Muraro, R Murray, L Nogueira-Silva, N G Papadopoulos, G Passalacqua, F Portejoie, D Price, D Ryan, B Samolinski, A Sheikh, V Siroux, O Spranger, A Todo Bom, P V Tomazic, A Valero, E Valovirta, A Valiulis, O VandenPlas, S van der Meulen, M van Eerd, M Wickman, T Zuberbier
BACKGROUND: The use of Apps running on smartphones and tablets profoundly affects medicine. The MASK-rhinitis (MACVIA-ARIA Sentinel NetworK for allergic rhinitis) App (Allergy Diary) assesses allergic rhinitis symptoms, disease control and impact on patients' lives. It is freely available in 20 countries (iOS and Android platforms). AIMS: To assess in a pilot study whether (i) Allergy Diary users were able to properly provide baseline characteristics (ii) simple phenotypic characteristics based upon data captured by the Allergy Diary could be identified and (iii) information gathered by this study could suggest novel research questions...
January 10, 2017: Allergy
https://www.readbyqxmd.com/read/27999855/building-bridges-for-innovation-in-ageing-synergies-between-action-groups-of-the-eip-on-aha
#9
J Bousquet, M Bewick, A Cano, P Eklund, G Fico, N Goswami, N A Guldemond, D Henderson, M J Hinkema, G Liotta, A Mair, W Molloy, A Monaco, I Monsonis-Paya, A Nizinska, H Papadopoulos, A Pavlickova, S Pecorelli, A Prados-Torres, R E Roller-Wirnsberger, D Somekh, C Vera-Muñoz, F Visser, J Farrell, J Malva, K Andersen Ranberg, T Camuzat, A M Carriazo, G Crooks, Z Gutter, G Iaccarino, E Manuel de Keenoy, G Moda, L Rodriguez-Mañas, T Vontetsianos, C Abreu, J Alonso, C Alonso-Bouzon, J Ankri, M T Arredondo, F Avolio, A Bedbrook, A Z Białoszewski, H Blain, R Bourret, M F Cabrera-Umpierrez, A Catala, R O'Caoimh, M Cesari, N H Chavannes, J Correia-da-Sousa, T Dedeu, M Ferrando, M Ferri, W J Fokkens, F Garcia-Lizana, O Guérin, P W Hellings, T Haahtela, M Illario, M C Inzerilli, K C Lodrup Carlsen, P Kardas, T Keil, M Maggio, A Mendez-Zorrilla, E Menditto, J Mercier, J P Michel, R Murray, M Nogues, I O'Byrne-Maguire, D Pappa, A S Parent, M Pastorino, C Robalo-Cordeiro, B Samolinski, P Siciliano, A M Teixeira, S I Tsartara, A Valiulis, O Vandenplas, T Vasankari, B Vellas, M Vollenbroek-Hutten, M Wickman, A Yorgancioglu, T Zuberbier, M Barbagallo, G W Canonica, L Klimek, S Maggi, W Aberer, C Akdis, I M Adcock, I Agache, C Albera, F Alonso-Trujillo, M Angel Guarcia, I Annesi-Maesano, J Apostolo, S H Arshad, V Attalin, A Avignon, C Bachert, I Baroni, E Bel, M Benson, C Bescos, F Blasi, C Barbara, K C Bergmann, P L Bernard, S Bonini, P J Bousquet, B Branchini, C E Brightling, V Bruguière, C Bunu, A Bush, D P Caimmi, M A Calderon, G Canovas, V Cardona, K H Carlsen, A Cesario, E Chkhartishvili, R Chiron, T Chivato, K F Chung, M d'Angelantonio, G De Carlo, D Cholley, F Chorin, B Combe, B Compas, D J Costa, E Costa, O Coste, A-L Coupet, G Crepaldi, A Custovic, R Dahl, S E Dahlen, P Demoly, P Devillier, A Didier, A T Dinh-Xuan, R Djukanovic, D Dokic, G Du Toit, R Dubakiene, A Dupeyron, R Emuzyte, A Fiocchi, A Wagner, M Fletcher, J Fonseca, B Fougère, A Gamkrelidze, G Garces, J Garcia-Aymeric, B Garcia-Zapirain, B Gemicioğlu, C Gouder, B Hellquist-Dahl, I Hermosilla-Gimeno, D Héve, C Holland, M Humbert, M Hyland, S L Johnston, J Just, M Jutel, I P Kaidashev, M Khaitov, O Kalayci, A F Kalyoncu, W Keijser, H Kerstjens, J Knezović, M Kowalski, G H Koppelman, T Kotska, M Kovac, I Kull, P Kuna, V Kvedariene, V Lepore, W MacNee, M Maggio, A Magnan, I Majer, P Manning, M Marcucci, T Marti, M Masoli, E Melen, N Miculinic, F Mihaltan, B Milenkovic, J Millot-Keurinck, H Mlinarić, I Momas, S Montefort, M Morais-Almeida, T Moreno-Casbas, R Mösges, J Mullol, R Nadif, M Nalin, E Navarro-Pardo, K Nekam, G Ninot, D Paccard, S Pais, E Palummeri, P Panzner, N K Papadopoulos, C Papanikolaou, G Passalacqua, E Pastor, M Perrot, D Plavec, T A Popov, D S Postma, D Price, N Raffort, J C Reuzeau, J M Robine, F Rodenas, F Robusto, N Roche, A Romano, V Romano, J Rosado-Pinto, F Roubille, F Ruiz, D Ryan, T Salcedo, P Schmid-Grendelmeier, H Schulz, H J Schunemann, E Serrano, A Sheikh, M Shields, N Siafakas, N Scichilone, P Siciliano, I Skrindo, H A Smit, S Sourdet, E Sousa-Costa, O Spranger, T Sooronbaev, V Sruk, P J Sterk, A Todo-Bom, J Touchon, D Tramontano, M Triggiani, S I Tsartara, A L Valero, E Valovirta, E van Ganse, M van Hage, M van den Berge, O Vandenplas, M T Ventura, I Vergara, G Vezzani, D Vidal, G Viegi, M Wagemann, B Whalley, M Wickman, N Wilson, P K Yiallouros, M Žagar, A Zaidi, M Zidarn, E J Hoogerwerf, J Usero, R Zuffada, A Senn, B de Oliveira-Alves
The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27997716/collagen-like-proteins-of-pathogenic-streptococci
#10
REVIEW
Slawomir Lukomski, Beth A Bachert, Flavia Squeglia, Rita Berisio
The collagen domain, which is defined by the presence of the Gly-X-Y triplet repeats, is amongst the most versatile and widespread known structures found in proteins from organisms representing all three domains of life. The streptococcal collagen-like (Scl) proteins are widely present in pathogenic streptococci, including Streptococcus pyogenes, S. agalactiae, S. pneumoniae, and S. equi. Experiments and bioinformatic analyses support the hypothesis that all Scl proteins are homotrimeric and cell wall-anchored...
December 20, 2016: Molecular Microbiology
https://www.readbyqxmd.com/read/27931279/mp-azeflu-provides-rapid-and-effective-allergic-rhinitis-control-in-real-life-a-pan-european-study
#11
Ludger Klimek, Claus Bachert, Par Stjrne, Ralph Dollner, Petter Larsen, Peter Haahr, Ioana Agache, Glenis Scadding, David Price
BACKGROUND: The European Union has prioritized allergic rhinitis (AR) control. Contre les Maladies Chronique pour un Vieillissement Actif Allergic Rhinitis and its Impact on Asthma has endorsed the visual analog scale (VAS) as the AR control language and incorporated it into a new AR treatment algorithm. Concurrently, the Respiratory Effectiveness Group and the European Academy of Allergy and Clinical Immunology are striving to improve the quality of published real-life AR research. Our aim was to assess the effectiveness of MP-AzeFlu by using a VAS in a well-designed, real-life, pan-European study...
September 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27895895/allergy-immunotherapy-across-the-life-cycle-to-promote-active-and-healthy-ageing-from-research-to-policies-an-airways-integrated-care-pathways-icps-programme-item-action-plan-b3-of-the-european-innovation-partnership-on-active-and-healthy-ageing-and-the-global
#12
REVIEW
M A Calderon, P Demoly, T Casale, C A Akdis, C Bachert, M Bewick, B M Bilò, B Bohle, S Bonini, A Bush, D P Caimmi, G W Canonica, V Cardona, A M Chiriac, L Cox, A Custovic, F De Blay, P Devillier, A Didier, G Di Lorenzo, G Du Toit, S R Durham, P Eng, A Fiocchi, A T Fox, R Gerth van Wijk, R M Gomez, T Haathela, S Halken, P W Hellings, L Jacobsen, J Just, L K Tanno, J Kleine-Tebbe, L Klimek, E F Knol, P Kuna, D E Larenas-Linnemann, A Linneberg, M Matricardi, H J Malling, R Moesges, J Mullol, A Muraro, N Papadopoulos, G Passalacqua, E Pastorello, O Pfaar, D Price, P Rodriguez Del Rio, R Ruëff, B Samolinski, G K Scadding, G Senti, M H Shamji, A Sheikh, J C Sisul, D Sole, G J Sturm, A Tabar, R Van Ree, M T Ventura, C Vidal, E M Varga, M Worm, T Zuberbier, J Bousquet
Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults. The current paper was developed by a working group of AIRWAYS integrated care pathways for airways diseases, the model of chronic respiratory diseases of the European Innovation Partnership on active and healthy ageing (DG CONNECT and DG Santé). It considered (1) the political background, (2) the rationale for allergen immunotherapy across the life cycle, (3) the unmet needs for the treatment, in particular in preschool children and old age adults, (4) the strategic framework and the practical approach to synergize current initiatives in allergen immunotherapy, its mechanisms and the concept of active and healthy ageing...
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27891215/hypothesis-may-e-cigarette-smoking-boost-the-allergic-epidemic
#13
EDITORIAL
Jean Bousquet, Claus Bachert, Laura Crotty Alexander, Frank T Leone
No abstract text is available yet for this article.
2016: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/27871865/iterative-reconstruction-of-radially-sampled-31-p-bssfp-data-using-prior-information-from-1-h-mri
#14
Kristian Rink, Nadia Benkhedah, Moritz C Berger, Christine Gnahm, Nicolas G R Behl, Jonathan M Lommen, Vanessa Stahl, Peter Bachert, Mark E Ladd, Armin M Nagel
The purpose of this study is to improve direct phosphorus ((31)P) MR imaging. Therefore, 3D density-adapted radially-sampled balanced steady-state free precession (bSSFP) sequences were developed and an iterative approach exploiting additional anatomical information from hydrogen ((1)H) data was evaluated. Three healthy volunteers were examined at B0=7T in order to obtain the spatial distribution of the phosphocreatine (PCr) intensities in the human calf muscle with a nominal isotropic resolution of 10mm in an acquisition time of 10min...
November 19, 2016: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/27859838/aggregation-induced-changes-in-the-chemical-exchange-saturation-transfer-cest-signals-of-proteins
#15
Steffen Goerke, Katharina S Milde, Raul Bukowiecki, Patrick Kunz, Karel D Klika, Thomas Wiglenda, Axel Mogk, Erich E Wanker, Bernd Bukau, Mark E Ladd, Peter Bachert, Moritz Zaiss
Chemical exchange saturation transfer (CEST) is an MRI technique that allows mapping of biomolecules (small metabolites, proteins) with nearly the sensitivity of conventional water proton MRI. In living organisms, several tissue-specific CEST effects have been observed and successfully applied to diagnostic imaging. In these studies, particularly the signals of proteins showed a distinct correlation with pathological changes. However, as CEST effects depend on various properties that determine and affect the chemical exchange processes, the origins of the observed signal changes remain to be understood...
January 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/27817798/advances-in-rhinitis-and-rhinosinusitis-in-2015
#16
REVIEW
Claus Bachert, Elien Gevaert
The last year has seen great progress in the understanding of upper airway disease and in its management. For allergic rhinitis, authors focused on the prediction of and effect on the natural course of disease. New evidence was published for the disease-modifying effect of allergen immunotherapy in terms of avoidance of new sensitizations and prevention of asthma in either randomized or real-life studies. Specifically, for patients with house dust mite allergies, which are often underestimated and difficult to diagnose, the efficacy of SQ house dust mite sublingual immunotherapy tablets has been demonstrated in patients with allergic rhinitis and asthma...
November 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27770460/alcohol-hyper-responsiveness-in-chronic-rhinosinusitis-with-nasal-polyps
#17
Els De Schryver, Lara Derycke, Paloma Campo, Eline Gabriels, Guy F Joos, Thibaut Van Zele, Claus Bachert, Peter W Hellings, Philippe Gevaert
BACKGROUND: An important percentage of subjects diagnosed with chronic upper airway disease report alcohol-induced worsening of their symptoms. The prevalence and characteristics of respiratory reactions provoked by alcohol-containing drinks have not been fully investigated yet. OBJECTIVE: The aim of this study was to estimate the prevalence and characteristics of alcohol hyper-responsiveness in patients with chronic airway disease and healthy controls. Furthermore, nasal inflammation was evaluated in nasal polyp patients with and without hyper-responsiveness...
October 22, 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27697498/validation-of-the-ga-2-len-chamber-for-trials-in-allergy-innovation-of-a-mobile-allergen-exposure-chamber
#18
Torsten Zuberbier, Mark B Abelson, Cezmi A Akdis, Claus Bachert, Uwe Berger, Carsten Bindslev-Jensen, Georg Boelke, Jean Bousquet, Giorgio Walter Canonica, Thomas B Casale, Marek Jutel, Marek L Kowalski, Enzo Madonini, Nikolaos G Papadopoulos, Oliver Pfaar, Torsten Sehlinger, Karl-Christian Bergmann
BACKGROUND: Field clinical trials of pollen allergy are impacted by the impossibility to predict and to determine individual allergen exposure, due to many factors (e.g., pollen season, atmospheric variations, pollutants, lifestyles). Environmental exposure chambers (EEC), delivering a fixed amount of allergens in a controlled environmental setting, can overcome these limitations. EECs are currently already used in phase 2, 3, and even 4 trials. Unfortunately, few chambers exist in the world, and this makes it difficult to perform large, multicenter clinical trials...
September 30, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27695877/-when-a-name-becomes-a-unit-nikola-tesla
#19
G van Kaick, P Bachert
No abstract text is available yet for this article.
November 2016: Der Radiologe
https://www.readbyqxmd.com/read/27632006/activity-detection-of-galnac-transferases-by-protein-based-fluorescence-sensors-in-vivo
#20
Lina Song, Collin Bachert, Adam D Linstedt
Mucin-type O-glycosylation occurring in the Golgi apparatus is an important protein posttranslational modification initiated by up to 20 GalNAc-transferase isozymes with largely distinct substrate specificities. Regulation of this enzyme family affects a vast array of proteins transiting the secretory pathway and misregulation causes human diseases. Here we describe the use of protein-based fluorescence sensors that traffic in the secretory pathway to monitor GalNAc-transferase activity in living cells. The sensors can either be "pan" or isozyme specific...
2016: Methods in Molecular Biology
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