keyword
https://read.qxmd.com/read/38534102/reply-to-cossu-et-al-switching-to-deltoid-intramuscular-injections-maintains-therapeutic-trough-concentrations-of-rilpivirine-and-cabotegravir-in-people-with-hiv
#1
JOURNAL ARTICLE
Kelong Han
No abstract text is available yet for this article.
March 27, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38531974/exploring-the-potential-of-ziziphus-nummularia-and-luteolin-7-o-glucoside-as-tubulin-inhibitors-in-cancer-therapy-and-survival
#2
JOURNAL ARTICLE
Sahar Saleh Alghamdi, Sara Abdulaziz Alghashem, Rizwan Ali, Arwa Alsubait, Rasha Saad Suliman, Afrah E Mohammed, Zeyad Alehaideb, Raghad Abdullah Alshafi, Allulu Yousef Alturki, Ishrat Rahman
Cancer is responsible for approximately 10 million deaths worldwide, with 70% of the deaths occurring in low- and middle-income countries; as such safer and more effective anti-cancer drugs are required. Therefore, the potential benefits of Ziziphus nummularia and Ziziphus spina-christi as sources of anti-cancer agents were investigated. Z. nummularia and Z. spina-christi extracts were prepared using chloroform, ethanol, ethyl acetate, and water. The extracts' anti-cancer properties were determined using the MTT Cell Viability Assay in four cancer cell lines: breast (KAIMRC2 and MDA-MB-231), colorectal (HCT8), and liver (HepG2)...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531388/a-case-of-generalized-eosinophilic-pustular-folliculitis-treatment-with-jak-inhibitor
#3
JOURNAL ARTICLE
Chunzhi Zheng, Yueqian Yu, Guizhi Zhou, Hong Liu
AIM: This case study aims to report the efficacy and safety of a Janus kinase (JAK) inhibitor in the treatment of generalized eosinophilic pustular folliculitis (EPF). METHODS: We present a case of a 16-year-old Chinese patient who had been suffering from EPF for two years and had shown no response to both topical and systemic glucocorticoids. The patient was subsequently treated with oral tofacitinib at a dosage of 5mg daily. RESULTS: Significant remission of eruption and pruritus was observed in the patient upon treatment with tofacitinib...
December 2024: Journal of Dermatological Treatment
https://read.qxmd.com/read/38529375/case-report-a-case-of-metastatic-brafv600-mutated-melanoma-with-heart-failure-treated-with-immune-checkpoint-inhibitors-and-braf-mek-inhibitors
#4
Aya Nishizawa, Misaki Kawakami, Yasuyuki Kitahara
BACKGROUND: Novel therapies, immune checkpoint inhibitors (ICIs), and BRAF/MEK inhibitors (BRAFi/MEKi) provide unprecedented survival benefits for patients with advanced melanoma. However, the management of drug-induced adverse events is problematic for both agents and, although rare, can cause serious cardiac dysfunction. CASE REPORT: A 42-year-old male patient with no significant medical history noticed a fading dark brown patch on his left anterior chest, which had been there for 20 years, after his second coronavirus disease 2019 (COVID-19) vaccination...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38528940/risk-of-primary-gastrointestinal-lymphoma-in-patients-with-inflammatory-conditions-exposed-to-tumor-necrosis-factor-alpha-inhibitors-and-immunomodulators-a-case-control-study
#5
JOURNAL ARTICLE
Manuel B Braga-Neto, Jason Nasser, Xiao Xing Iris Wang, William Scott Harmsen, Laura E Raffals, Michael Camilleri, Victor Chedid
INTRODUCTION: The aim of this case-control study was to determine if exposure to tumor necrosis factor alpha inhibitors (TNFIs) or immunomodulators (thiopurines or methotrexate) was associated with development of primary gastrointestinal lymphoma (PGIL) in patients with chronic inflammatory conditions. METHODS: Patients with PGIL and controls evaluated at a tertiary care center over 20 years were matched 1:3 using a medical record informatics search engine based on their chronic inflammatory condition (Crohn's disease [CD], ulcerative colitis [UC], rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis) and duration of follow-up...
January 2024: Crohn's & colitis 360
https://read.qxmd.com/read/38528335/chronic-pain-management-in-a-cyp2d6-poor-metabolizer-a-case-report-for-oxycodone
#6
JOURNAL ARTICLE
Deepa Pednekar, Joshua Russell, Chandni Bardolia, David Thacker, Nishita Shah Amin
The objective of this case report is to illustrate pharmacogenomics (PGx)-guided oxycodone treatment, given the conflicting data on the analgesic response from oxycodone in Cytochrome P450 (CYP)2D6 poor metabolizers (PMs). PGx-guided therapy can help improve treatment outcomes. This case report describes a 58-year-old patient who was prescribed oxycodone for chronic pain management. The patient presented with a history of inadequate pain control despite analgesic treatment with oxycodone (morphine milliequivalent [MME] = 22...
April 1, 2024: Senior Care Pharmacist
https://read.qxmd.com/read/38527740/-chinese-expert-consensus-on-the-follow-up-management-of-patients-with-prostate-cancer-receiving-medical-castration-therapy%C3%AF-2024-edition%C3%AF
#7
JOURNAL ARTICLE
(no author information available yet)
With the advancement of prostate cancer (PCa) diagnosis and treatment technology, the 5-year survival rate has remarkably increased, and PCa has entered the era of chronic disease management. Medical castration therapy remains the cornerstone treatment option for PCa patients, and run throughout the various stages of patient treatment. The disease progression, treatment-related adverse reactions and related complications of PCa patients after medical castration have become a major problem in the long-term management of PCa patients, affecting the survival and quality of life of patients...
March 22, 2024: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://read.qxmd.com/read/38526196/a-gene-switch-platform-interfacing-with-reactive-oxygen-species-enables-transcription-fine-tuning-by-soluble-and-volatile-pharmacologics-and-food-additives
#8
JOURNAL ARTICLE
Jinbo Huang, Shuai Xue, Ana Palma Teixeira, Martin Fussenegger
Synthetic biology aims to engineer transgene switches for precise therapeutic protein control in cell-based gene therapies. However, off-the-shelf trigger-inducible gene circuits are usually switched on by single or structurally similar molecules. This study presents a mammalian gene-switch platform that controls therapeutic gene expression by a wide range of molecules generating low, non-toxic levels of reactive oxygen species (ROS). In this system, KEAP1 (Kelch-like ECH-associated protein 1) serves as ROS sensor, regulating the translocation of NRF2 (nuclear factor erythroid 2-related factor 2) to the nucleus, where NRF2 binds to  antioxidant response elements (ARE) to activate the expression of a gene of interest...
March 25, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38525773/advancing-care-in-severe-asthma-the-art-of-switching-biologics
#9
REVIEW
Silvano Dragonieri, Andrea Portacci, Vitaliano Nicola Quaranta, Giovanna Elisiana Carpagnano
Biologics targeting IgE, IL-5, IL-4/IL-13, and TSLP are crucial in severe asthma treatment. Research, including randomized controlled trials and real-world studies, has been conducted to assess their efficacy and identify patient characteristics that may predict positive responses. The effectiveness of switching biologics, especially given overlaps in treatment eligibility, and the clinical outcomes post-cessation are critical areas of investigation. This work reviews the effects of switching between these biologics and the indicators of treatment success or failure...
February 21, 2024: Advances in Respiratory Medicine
https://read.qxmd.com/read/38525488/shifting-from-the-treat-to-target-to-the-early-highly-effective-treatment-approach-in-patients-with-multiple-sclerosis-real-world-evidence-from-germany
#10
JOURNAL ARTICLE
Steffeni Papukchieva, Ann-Sophie Stratil, Maria Kahn, Nils-Henning Neß, Maike Hollnagel-Schmitz, Vivien Gerencser, Julia Rustemeier, Markus Eberl, Benjamin Friedrich, Tjalf Ziemssen
BACKGROUND: While evidence highlights the effectiveness of initiating disease-modifying therapy with a high-efficacy medication for multiple sclerosis (MS) patients with poor prognostic factors, it remains unclear whether this approach has been adopted by a broad range of MS providers in Germany yet. OBJECTIVE: To assess the adoption of the early highly effective treatment (EHT) compared to the treat-to-target treatment approach with the option of escalating treatment efficacy over time in Germany based on real-world evidence data...
2024: Therapeutic Advances in Neurological Disorders
https://read.qxmd.com/read/38525088/glycemic-control-in-patients-living-with-hiv-initiated-on-integrase-inhibitor-based-three-drug-antiretroviral-therapy
#11
JOURNAL ARTICLE
Anthony Gerber, Briann Fischetti, Olga Popova, Maria Longo
Background: The increased risk of cardio-metabolic disorders associated with people living with human immunodeficiency virus (HIV) is of growing importance. Given the broad adoption of integrase strand-transfer inhibitor (INSTI)-based antiretroviral therapy (ART) as first-line therapy for HIV, additional data are needed regarding the metabolic effects of these regimens. Objective: The purpose of this study is to assess glycemic control in patients started on INSTI-based 3-drug regimens over a 2-year period...
April 2024: Journal of Pharmacy Technology: JPT: Official Publication of the Association of Pharmacy Technicians
https://read.qxmd.com/read/38524940/effectiveness-of-insulin-degludec-liraglutide-versus-insulin-degludec-insulin-aspart-in-japanese-patients-with-type-2-diabetes
#12
JOURNAL ARTICLE
Junko Oya, Tomoko Nakagami, Yukiko Hasegawa, Yuichiro Kondo, Aki Katamine, Mika Shimizu, Ryo Kubota, Rika Suda, Tetsuya Babazono
AIMS: To evaluate and compare the effectiveness of once-daily insulin degludec/liraglutide (IDegLira) to that of once-daily insulin degludec/insulin aspart (IDegAsp) after switching from basal insulin therapy at 6 months by assessing changes in hemoglobin A1c (HbA1c), body weight, and insulin doses in patients with type 2 diabetes (T2D). MATERIALS AND METHODS: A total of 91 patients with T2D with HbA1c levels exceeding 7.0% were included in this study. Adjusted least square mean changes in HbA1c, body weight, and total insulin doses were compared between the IDegLira group and IDegAsp group...
April 2024: Diabetology International
https://read.qxmd.com/read/38524659/anthracycline-based-hepatic-arterial-infusion-chemotherapy-achieved-17%C3%A2-months-of-disease-regression-in-a-patient-with-breast-cancer-liver-metastases-resistant-to-multiple-systemic-chemotherapies
#13
JOURNAL ARTICLE
Masahiro Kawashima, Takeshi Matsumoto, Takao Nishimura, Susumu Mashima, Atsushi Kobayashi, Eisho Kanemitsu, Hiromitsu Nagata, Toshihiro Tanaka, Yasuyuki Shimahara
Hepatic arterial infusion chemotherapy (HAIC) for liver metastases (LMs) from breast cancer is not a standard of care, but its effectiveness in patients with extensive LMs who cannot tolerate systemic therapy has been reported. Herein, we report a case of breast cancer LMs that were controlled by anthracycline-based HAIC. A 46-year-old woman with estrogen receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer who had multiple LMs and bone metastases underwent seven lines of systemic therapy (paclitaxel/bevacizumab for 38 months; letrozole, nivolumab/fulvestrant, eribulin, gemcitabine/vinorelbine, high-dose toremifene/abemaciclib, and capecitabine for 21 months in total)...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524658/significant-reduction-in-burden-of-metastatic-disease-by-intermittent-docetaxel-therapy-in-a-patient-with-castration-resistant-prostate-cancer
#14
JOURNAL ARTICLE
Takahiro Kirisawa, Eijiro Nakamura, Tomoya Okuno, Hiroki Hagimoto, Ayumu Matsuda, Yasuo Shinoda, Motokiyo Komiyama, Hiroyuki Fujimoto, Yoshiyuki Matsui
Intermittent docetaxel therapy (IDT) is rarely used nowadays as a treatment option for men with metastatic castration-resistant prostate cancer (mCRPC) because of the widespread availability of androgen receptor axis-targeted therapy, which is less toxic. Therefore, there is limited information available on whether IDT has a clinical benefit in the treatment of men with mCRPC. This report describes the case of a 66-year-old man with a diagnosis of cT2N1M0 prostate cancer who underwent neoadjuvant combined androgen blockade and whole-pelvis radiation therapy...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524642/durvalumab-plus-carboplatin-etoposide-treatment-in-a-patient-with-small-cell-lung-cancer-on-hemodialysis-a-case-report-and-literature-review
#15
JOURNAL ARTICLE
Futoshi Ushijima, Tetsunari Hase, Yuki Yamashita, Hangsoo Kim, Tomoya Shimokata, Chiaki Kondo, Tomonori Sato, Tomoya Baba, Shohei Watanabe, Keisuke Futamura, Yuichi Ando, Masashi Mizuno, Makoto Ishii
Little is known about the efficacy and safety of durvalumab plus carboplatin-etoposide treatment in patients with extensive-disease (ED) small-cell lung cancer (SCLC) on hemodialysis. Here, we present a case of a 67-year-old man with pleuroperitoneal communication on continuous ambulatory peritoneal dialysis who was diagnosed with ED-SCLC based on a cytological analysis of the peritoneal fluid. He was switched from peritoneal dialysis to hemodialysis and received durvalumab (1500 mg/body on day 1) plus carboplatin (area under the concentration-time curve = 5, 125 mg on day 1) and etoposide (50 mg/m2 on days 1 and 3) as first-line therapy...
April 2024: International cancer conference journal
https://read.qxmd.com/read/38524636/semaglutide-as-a-potential-therapeutic-alternative-for-hnf1b-mody-a-case-study
#16
Angham Almutair, Beshaier Almulhem
Maturity-onset diabetes of the young (MODY) is a grouping of monogenic disorders. It is characterized by dominantly inherited, non-insulin-dependent diabetes. MODY is relatively rare, encompassing up to 3.5% in those diagnosed under 30 years of age. Specific types are most commonly treated with sulfonylurea, particularly those identified as HNF4A-MODY and HNF1A-MODY. HNF1B-MODY is another type that is most frequently managed with insulin therapy but lacks a defined precision treatment. We present an 18-year-old, non-obese female patient diagnosed with HNF1B-MODY...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38524593/a-case-of-multiple-art-intolerance-responds-to-albuvirtide-and-dolutegravir-case-report-and-literature-review
#17
Zhong Chen, Tan Si, Li Ying, Cao Guiying, Xiè Jiàn Píng, Min Wang
Upon confirming an HIV diagnosis, patients need to start life-long antiretroviral therapy (ART) as soon as possible. During HIV treatment, ART drugs can cause intolerable adverse reactions, leading to poor medication compliance, treatment failure, and advancement of the HIV stage. Herein, we report a case of AIDS intolerant to multiple antiviral drugs due to side effects that we finally stabilized with the Albuvirtide (ABT) and Dolutegravir (DTG) combination. A 48 -year-old woman developed intractable nausea, vomiting and abdominal discomfort within one month of starting ART...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524130/an-updated-management-approach-of-pompe-disease-patients-with-high-sustained-anti-rhgaa-igg-antibody-titers-experience-with-bortezomib-based-immunomodulation
#18
JOURNAL ARTICLE
Ankit K Desai, Garima Shrivastava, Christina L Grant, Raymond Y Wang, Trevor D Burt, Priya S Kishnani
INTRODUCTION: High sustained anti-rhGAA antibody titers (HSAT; ≥12,800) are directly linked to reduced efficacy of enzyme replacement therapy (ERT) and subsequent clinical deterioration in infantile-onset Pompe disease (IOPD). We have previously demonstrated the safety and effectiveness of a bortezomib-based immune-tolerance induction (ITI) regimen (bortezomib, rituximab, methotrexate, and IVIG) in eliminating HSAT. METHODS: Here, we describe two IOPD cases (patients 6 and 8) who developed HSAT at 8 and 10 weeks on ERT despite transient low-dose methotrexate ITI administration in the ERT-naïve setting and were treated with a bortezomib-based ITI regimen, and we compare their courses to a series of six historical patients (patients 1-5, and 7) with a similar presentation who exemplify our evolving approach to treatment...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38523850/an-overlooked-medication-induced-celiac-flare-complicating-treatment-of-osteoporosis
#19
Van Phan, John Aurora, Suma Gondi, Lisa Ceglia
BACKGROUND/OBJECTIVE: Celiac disease, an immune reaction to gluten causing nutrient malabsorption, and long-term glucocorticoid therapy adversely affect bone metabolism and increase fracture risk. CASE REPORT: A patient with long-standing celiac disease on a strict gluten-free diet and long-term glucocorticoid therapy status post kidney transplant for Sjögren syndrome-induced interstitial nephritis presented for management of osteoporosis. Initial evaluation was notable for secondary hyperparathyroidism, which resolved after switching to a gluten-free calcium citrate supplement...
2024: AACE Clinical Case Reports
https://read.qxmd.com/read/38523452/live-attenuated-vaccination-in-patients-with-inflammatory-bowel-disease-while-continuing-or-after-elective-switch-to-vedolizumab
#20
JOURNAL ARTICLE
Hisashi Shiga, Hiroshi Nagai, Yusuke Shimoyama, Takeo Naito, Rintaro Moroi, Yoichi Kakuta, Yoshitaka Kinouchi, Atsushi Masamune
BACKGROUND/AIMS: Vedolizumab (VDZ) is a gut-selective agent with a favorable safety profile. We aimed to assess the feasibility of elective switch from other advanced therapies to VDZ and subsequent live-attenuated vaccination while continuing VDZ in patients with inflammatory bowel diseases (IBD). METHODS: We measured antibody titers specific for measles, rubella, mumps, and varicella viruses in IBD patients under immunosuppressive therapy. Those with negative titers and without vaccination history were judged unimmunized...
March 26, 2024: Intestinal Research
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