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"camkii" OR "calcium/calmodulin dependent kinase type II"

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https://www.readbyqxmd.com/read/29452071/camkii-inhibition-ameliorated-levodopa-induced-dyskinesia-by-downregulating-tyrosine-hydroxylase-activity-in-an-experimental-model-of-parkinson-s-disease
#1
Xinxin Yang, Zhongfang Zhu, Xiqing Ding, Xiaoying Wang, Guiyun Cui, Fang Hua, Jie Xiang
Levodopa (L-dopa) remains the best treatment for Parkinson's disease (PD). However, long-term L-dopa treatment induces dyskinesia. The mechanism of L-dopa-induced dyskinesia (LID) is not fully understood. Enhanced activity of protein kinase A (PKA) and pulsatile dopamine (DA) stimulation plays an important role in LID. Tyrosine hydroxylase (TH) is the rate-limiting enzyme for DA synthesis. Decreased TH activity causes reduced pulsatile DA stimulation, which in turn reduces LID. Moreover, TH is a substrate of CaMKII...
February 14, 2018: Brain Research
https://www.readbyqxmd.com/read/29439248/transient-receptor-potential-vanilloid-4-activation-induced-increase-in-glycine-activated-current-in-mouse-hippocampal-pyramidal-neurons
#2
Mengwen Qi, Chunfeng Wu, Zhouqing Wang, Li Zhou, Chen Men, Yimei Du, Songming Huang, Lei Chen, Ling Chen
BACKGROUND/AIMS: Glycine plays an important role in regulating hippocampal inhibitory/ excitatory neurotransmission through activating glycine receptors (GlyRs) and acting as a co-agonist of N-methyl-d-aspartate-type glutamate receptors. Activation of transient receptor potential vanilloid 4 (TRPV4) is reported to inhibit hippocampal A-type γ-aminobutyric acid receptor, a ligand-gated chloride ion channel. GlyRs are also ligand-gated chloride ion channels and this paper aimed to explore whether activation of TRPV4 could modulate GlyRs...
February 7, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29432608/age-dependent-increase-in-jnk2-activity-does-this-help-to-understand-camkii-mediated-atrial-arrhythmogenesis-in-human-atrial-fibrillation
#3
Dobromir Dobrev, Kristina Lorenz
No abstract text is available yet for this article.
February 8, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29427622/secreted-agr2-promotes-invasion-of-colorectal-cancer-cells-via-wnt11-mediated-non-canonical-wnt-signaling
#4
Shaobo Tian, Jia Hu, Kaixiong Tao, Jian Wang, Yanan Chu, Jing Li, Zhibo Liu, Xueliang Ding, Luming Xu, Qilin Li, Ming Cai, Jinbo Gao, Xiaoming Shuai, Guobin Wang, Lin Wang, Zheng Wang
Human anterior gradient-2 (AGR2), a member of protein disulfide isomerase (PDI) family, is present in both intracellular and extracellular compartments. Although AGR2 is overexpressed in various human cancers and reported to promote aggressive tumor features, little is known regarding AGR2's extracellular functions during tumorigenesis. Here, we demonstrate that secreted AGR2 promotes cell migration and metastasis of colorectal cancer (CRC) in vitro and in vivo. Mechanistically, secreted AGR2 elevated Wnt11 expression, triggering non-canonical Wnt signaling: the Ca2+/Calmodulin-dependent protein kinase II (CaMKII) and c-jun amino-terminal kinase (JNK) pathways...
February 7, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29427611/imaging-pathological-activities-of-human-brain-tissue-in-organotypic-culture
#5
Caroline Le Duigou, Etienne Savary, Mélanie Morin-Brureau, Daniel Gomez-Dominguez, André Sobczyk, Farah Chali, Giampaolo Milior, Larissa Kraus, Jochen C Meier, Dimitri M Kullmann, Bertrand Mathon, Liset Menendez de la Prida, Georg Dorfmuller, Johan Pallud, Emmanuel Eugène, Stéphane Clemenceau, Richard Miles
BACKGROUND: Insights into human brain diseases may emerge from tissue obtained after operations on patients. However techniques requiring transduction of transgenes carried by viral vectors cannot be applied to acute human tissue. NEW METHOD: We show that organotypic culture techniques can be used to maintain tissue from patients with three different neurological syndromes for several weeks in vitro. Optimized viral vector techniques and promoters for transgene expression are described...
February 7, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29427172/up-regulation-of-ca-2-camkii-creb-signaling-in-salicylate-induced-tinnitus-in-rats
#6
Jiuhan Zhao, Biao Wang, Xiaohong Wang, Xiuli Shang
The purpose of the study was to investigate the changes of Ca2+/calmodulin-dependent protein kinases II (CaMKII)/cAMP response element-binding protein (CREB) signaling pathway in a rat tinnitus model. Eighteen Wistar rats were randomly divided into three groups: normal control (NC), normal saline (NS), and tinnitus model (TM) groups. Tinnitus model was induced by intraperitoneal injection of salicylate. The concentration of intracellular calcium level in auditory cortex cells was determined using Fura-2 acetoxymethyl ester (Fura-2 AM) method with fluorospectrophotometer...
February 9, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29426014/network-analysis-of-ube3a-e6ap-associated-proteins-provides-connections-to-several-distinct-cellular-processes
#7
Gustavo Martínez-Noël, Katja Luck, Simone Kühnle, Alice Desbuleux, Patricia Szajner, Jeffrey T Galligan, Diana Rodriguez, Leon Zheng, Kathleen Boyland, Flavian Leclere, Quan Zhong, David E Hill, Marc Vidal, Peter M Howley
Perturbations in activity and dosage of the UBE3A ubiquitin-ligase have been linked to Angelman Syndrome and autism spectrum disorders. UBE3A was initially identified as the cellular protein hijacked by the human papillomavirus E6 protein to mediate the ubiquitylation of p53, a function critical to the oncogenic potential of these viruses. Although a number of substrates have been identified, the normal cellular functions and pathways affected by UBE3A are largely unknown. Previously we showed that UBE3A associates with HERC2, NEURL4, and MAPK6/ERK3 in a high molecular weight complex of unknown function that we refer to as the HUN complex (HERC2, UBE3A, and NEURL4)...
February 6, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29422059/hyperammonemia-alters-membrane-expression-of-glua1-and-glua2-subunits-of-ampa-receptors-in-hippocampus-by-enhancing-activation-of-the-il-1-receptor-underlying-mechanisms
#8
Lucas Taoro-Gonzalez, Yaiza M Arenas, Andrea Cabrera-Pastor, Vicente Felipo
BACKGROUND: Hyperammonemic rats reproduce the cognitive alterations of patients with hepatic encephalopathy, including altered spatial memory, attributed to altered membrane expression of AMPA receptor subunits in hippocampus. Neuroinflammation mediates these cognitive alterations. We hypothesized that hyperammonemia-induced increase in IL-1β in hippocampus would be responsible for the altered GluA1 and GluA2 membrane expression. The aims of this work were to (1) assess if increased IL-1β levels and activation of its receptor are responsible for the changes in GluA1 and/or GluA2 membrane expression in hyperammonemia and (2) identify the mechanisms by which activation of IL-1 receptor leads to altered membrane expression of GluA1 and GluA2...
February 8, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29417944/epicatechin-potentiation-of-glucose-stimulated-insulin-secretion-in-ins-1-cells-is-not-dependent-on-its-antioxidant-activity
#9
Kaiyuan Yang, Catherine B Chan
Epicatechin (EC) is a monomeric flavan-3-ol. We have previously demonstrated that glucose-intolerant rats fed flavan-3-ols exhibit improved pancreatic islet function corresponding with an increase in circulating EC-derived metabolites. Thus, we speculate that EC may act as a cellular signaling molecule in vivo to modulate insulin secretion. In this study we further examined the effects of different concentrations of EC on H2O2 or hyperglycemia-induced ROS production, as well as on saturated fatty acid (SFA)-impaired glucose-stimulated insulin secretion (GSIS) in INS-1 cell line in vitro...
February 8, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29414768/lipids-and-phosphates-at-odds-in-synaptic-depression
#10
Anton Omelchenko, Bonnie L Firestein
Long-term depression (LTD) is a reduction in the efficacy of neuronal synapses, but the molecular basis of LTD signaling and how these signals lead to phenotypic outcomes, such as the shrinkage of synaptic regions, is not clear. In a new report, Woolfrey et al use chemically-induced LTD and a multitude of in vitro biochemical assays to provide evidence that synaptic removal of the scaffolding protein AKAP79/150 promotes LTD-induced spine shrinkage. The further identification of CaMKII, a kinase primarily associated with long-term potentiation (LTP), as a requirement for AKAP79/150 removal, uncovers unexpected interplay between different post-translational modifications and points to a new model of LTD...
February 2, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29410242/sr-ca2-leak-and-disordered-excitation-contraction-coupling-as-the-basis-for-arrhythmogenic-and-negative-inotropic-effects-of-acute-ethanol-exposure
#11
Julian Mustroph, Olivia Wagemann, Simon Lebek, Daniel Tarnowski, Jasmin Ackermann, Marzena Drzymalski, Steffen Pabel, Christof Schmid, Stefan Wagner, Samuel Sossalla, Lars S Maier, Stefan Neef
AIMS: Ethanol has acute negative inotropic and arrhythmogenic effects. The underlying mechanisms, however, are largely unknown. Sarcoplasmic reticulum Ca2+-leak is an important mechanism for reduced contractility and arrhythmias. Ca2+-leak can be induced by oxidative stress and Ca2+/Calmodulin-dependent protein kinase II (CaMKII). Therefore, we investigated the influence of acute ethanol exposure on excitation-contraction coupling in atrial and ventricular cardiomyocytes. METHODS AND RESULTS: Isolated human atrial and murine atrial or ventricular cardiomyocytes were preincubated for 30 min and then superfused with control solution or solution containing ethanol...
February 2, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29410121/calcium-calmodulin-dependent-protein-kinase-ii-regulation-of-iks-during-sustained-beta-adrenergic-receptor-stimulation
#12
Tyler Shugg, Derrick E Johnson, Minghai Shao, Xianyin Lai, Frank Witzmann, Theodore R Cummins, Michael Rubart-Von-der Lohe, Andy Hudmon, Brian R Overholser
BACKGROUND: Sustained β-adrenergic receptor (β-AR) stimulation causes pathophysiologic changes during heart failure (HF), including inhibition of the slow component of the delayed rectifier current, IKs. Aberrant calcium handling, including increased activation of calcium/calmodulin-dependent protein kinase II (CaMKII), contributes to arrhythmia development during HF. OBJECTIVE: To investigate CaMKII regulation of KCNQ1 (pore-forming subunit of IKs) during sustained β-AR stimulation and associated functional implications on IKs...
February 1, 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29409723/camkii-in-vascular-signalling-friend-or-foe
#13
REVIEW
Obialunanma V Ebenebe, Alison Heather, Jeffrey R Erickson
Signalling mechanisms within and between cells of the vasculature enable function and maintain homeostasis. However, a number of these mechanisms also contribute to the pathophysiology of vascular disease states. The multifunctional signalling molecule calcium/calmodulin-dependent kinase II (CaMKII) has been shown to have critical functional effects in many tissue types. For example, CaMKII is known to have a dual role in cardiac physiology and pathology. The function of CaMKII within the vasculature is incompletely understood, but emerging evidence points to potential physiological and pathological roles...
December 19, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29407107/protection-against-reperfusion-injury-by-3-4-dihydroxyflavonol-in-rat-isolated-hearts-involves-inhibition-of-phospholamban-and-jnk2
#14
Kai Yee Chin, Lokugan S Silva, Ian A Darby, Dominic C H Ng, Owen L Woodman
BACKGROUND: Flavonols, including 3',4'-dihydroxyflavonol (DiOHF), reduce myocardial ischemia and reperfusion (I/R) injury but their mechanism remains uncertain. To better understand the mechanism of the cardioprotective actions of flavonols we investigated the effect of DiOHF on cardiac function and the activation of protective and injurious signalling kinases after I/R in rat isolated hearts. METHODS: We assessed the effect of global ischemia (20min) and reperfusion (5-30min) on cardiac function and injury in rat isolated, perfused hearts in the absence or presence of DiOHF (10μM) during reperfusion...
March 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29402414/camkii-mediated-phosphorylation-of-ryr2-plays-a-crucial-role-in-aberrant-ca2-release-as-an-arrhythmogenic-substrate-in-cardiac-troponin-t-related-familial-hypertrophic-cardiomyopathy
#15
Shinichi Okuda, Yoko Sufu-Shimizu, Takayoshi Kato, Masakazu Fukuda, Shigehiko Nishimura, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto, Sachio Morimoto, Masafumi Yano
AIMS: Cardiac Troponin T (TnT) mutation-linked familial hypertrophic cardiomyopathy (FHC) is known to cause sudden cardiac death at a young age. Here, we investigated the role of the Ca2+ release channel of the cardiac sarcoplasmic reticulum (SR), ryanodine receptor (RyR2), in the pathogenic mechanism of lethal arrhythmia in FHC-related TnT-mutated transgenic mice (TG; TnT-delta160E). METHODS AND RESULTS: In TG cardiomyocytes, the Ca2+ spark frequency (SpF) was much higher than that in non-TG cardiomyocytes...
January 31, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29401454/biophysical-attributes-that-affect-camkii-activation-deduced-with-a-novel-spatial-stochastic-simulation-approach
#16
Ximing Li, William R Holmes
Calcium/calmodulin-dependent protein kinase II (CaMKII) holoenzymes play a critical role in decoding Ca2+ signals in neurons. Understanding how this occurs has been the focus of numerous studies including many that use models. However, CaMKII is notoriously difficult to simulate in detail because of its multi-subunit nature, which causes a combinatorial explosion in the number of species that must be modeled. To study the Ca2+-calmodulin-CaMKII reaction network with detailed kinetics while including the effect of diffusion, we have customized an existing stochastic particle-based simulator, Smoldyn, to manage the problem of combinatorial explosion...
February 5, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29395358/stimulation-induced-changes-in-diffusion-and-structure-of-calmodulin-and-calmodulin-dependent-protein-kinase-ii-proteins-in-neurons
#17
Morteza Heidarinejad, Hideki Nakamura, Takafumi Inoue
Calcium/calmodulin-dependent protein kinase II (CaMKII) and calmodulin (CaM) play essential roles in synaptic plasticity, which is an elementary process of learning and memory. In this study, fluorescence correlation spectroscopy (FCS) revealed diffusion properties of CaM, CaMKIIα and CaMKIIβ proteins in human embryonic kidney 293 (HEK293) cells and hippocampal neurons. A simultaneous multiple-point FCS recording system was developed on a random-access two-photon microscope, which facilitated efficient analysis of molecular dynamics in neuronal compartments...
January 29, 2018: Neuroscience Research
https://www.readbyqxmd.com/read/29395043/calcium-calmodulin-dependent-protein-kinase-ii-and-eukaryotic-elongation-factor-2-kinase-pathways-mediate-the-antidepressant-action-of-ketamine
#18
Chinnakkaruppan Adaikkan, Elham Taha, Iliana Barrera, Orit David, Kobi Rosenblum
BACKGROUND: Ketamine is an N-methyl-D-aspartate receptor antagonist, which on administration produces fast-acting antidepressant responses in patients with major depressive disorder. Yet, the mechanism underlying the antidepressant action of ketamine remains unclear. METHODS: To unravel the mechanism of action of ketamine, we treated wild-type C57BL/6 mice with calcium/calmodulin-dependent protein kinase II (CaMKII) specific inhibitor tatCN21 peptide. We also used eukaryotic elongation factor 2 kinase (eEF2K) (also known as CaMKIII) knockout mice...
December 5, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29391029/mfn2-ablation-causes-an-oxidative-stress-response-and-eventual-neuronal-death-in-the-hippocampus-and-cortex
#19
Sirui Jiang, Priya Nandy, Wenzhang Wang, Xiaopin Ma, Jeffrey Hsia, Chunyu Wang, Zhenlian Wang, Mengyue Niu, Sandra L Siedlak, Sandy Torres, Hisashi Fujioka, Ying Xu, Hyoung-Gon Lee, George Perry, Jun Liu, Xiongwei Zhu
BACKGROUND: Mitochondria are the organelles responsible for energy metabolism and have a direct impact on neuronal function and survival. Mitochondrial abnormalities have been well characterized in Alzheimer Disease (AD). It is believed that mitochondrial fragmentation, due to impaired fission and fusion balance, likely causes mitochondrial dysfunction that underlies many aspects of neurodegenerative changes in AD. Mitochondrial fission and fusion proteins play a major role in maintaining the health and function of these important organelles...
February 1, 2018: Molecular Neurodegeneration
https://www.readbyqxmd.com/read/29383885/increased-fxyd1-and-pgc-1%C3%AE-mrna-after-blood-flow-restricted-running-is-related-to-fibre-type-specific-ampk-signalling-and-oxidative-stress-in-human-muscle
#20
Danny Christiansen, Robyn M Murphy, Jens Bangsbo, Christos G Stathis, David J Bishop
AIM: This study explored the effects of blood flow restriction (BFR) on mRNA responses of PGC-1α (total, 1α1, and 1α4) and Na+ ,K+ -ATPase isoforms (NKA; α1-3 , β1-3 , and FXYD1) to an interval running session, and determined if these effects were related to increased oxidative stress, hypoxia, and fibre type-specific AMPK and CaMKII signalling, in human skeletal muscle. METHODS: In a randomised, crossover fashion, eight healthy men (26 ± 5 y and 57.4 ± 6...
January 31, 2018: Acta Physiologica
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