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"camkii" OR "calcium/calmodulin dependent kinase type II"

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https://www.readbyqxmd.com/read/29913633/expression-of-calcium-calmodulin-dependent-protein-kinase-ii-in-dorsal-root-ganglia-in-diabetic-rats-6-months-and-1-year-after-diabetes-induction
#1
L Ferhatovic, A Jelicic, M Boric, A Banozic, D Sapunar, L Puljak
Aim The aim of this study was to compare expression of total calcium/calmodulin-dependent protein kinase II (tCaMKII) and its α, β, γ and δ isoforms in dorsal root ganglion (DRG) in rat models of diabetes mellitus type I (DM1), 6 months and 1 year after diabetes induction. Methods A total of 45 male Sprague-Dawley rats weighing 160-200 g were assigned into four experimental groups: 6-months DM1 and its control group, 1-year and its control group. For the induction of DM1, after overnight fasting animals were injected intraperitonealy with 55 mg/kg of the streptozotocine (STZ)...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913448/rapid-electrical-stimulation-increased-cardiac-apoptosis-through-disturbance-of-calcium-homeostasis-and-mitochondrial-dysfunction-in-human-induced-pluripotent-stem-cell-derived-cardiomyocytes
#2
Le Geng, Zidun Wang, Chang Cui, Yue Zhu, Jiaojiao Shi, Jiaxian Wang, Minglong Chen
BACKGROUND/AIMS: Heart failure induced by tachycardia, the most common arrhythmia, is frequently observed in clinical practice. This study was designed to investigate the underlying mechanisms. METHODS: Rapid electrical stimulation (RES) at a frequency of 3 Hz was applied on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) for 7 days, with 8 h/day and 24 h/day set to represent short-term and long-term tachycardia, respectively. Age-matched hiPSC-CMs without electrical stimulation or with slow electrical stimulation (1 Hz) were set as no electrical stimulation (NES) control or low-frequency electrical stimulation (LES) control...
June 15, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29913137/memantine-rescues-prenatal-citalopram-exposure-induced-striatal-and-social-abnormalities-in-mice
#3
Aqeela Zahra, Jinxiang Jiang, Yunan Chen, Cheng Long, Li Yang
Prenatal exposure to citalopram (CTM), an antidepressant drug, has been associated with altered behavior, including autism-like symptoms in both human and rodent offspring. However, the neurological basis underlying these abnormal behaviors is not well understood. Here, we examined behavioral, morphological, and biochemical alterations in the male and female offspring of C57BL/6 mouse mothers that had been exposed to CTM during the last trimester of gestation. We observed abnormal behavior such as anxiety, altered locomotion and disordered social interactions in 2-5 month old offspring with prenatal CTM exposure...
June 15, 2018: Experimental Neurology
https://www.readbyqxmd.com/read/29911178/rgs14-restricts-plasticity-in-hippocampal-ca2-by-limiting-postsynaptic-calcium-signaling
#4
Paul R Evans, Paula Parra-Bueno, Michael S Smirnov, Daniel J Lustberg, Serena M Dudek, John R Hepler, Ryohei Yasuda
Pyramidal neurons in hippocampal area CA2 are distinct from neighboring CA1 in that they resist synaptic long-term potentiation (LTP) at CA3 Schaffer collateral synapses. Regulator of G protein signaling 14 (RGS14) is a complex scaffolding protein enriched in CA2 dendritic spines that naturally blocks CA2 synaptic plasticity and hippocampus-dependent learning, but the cellular mechanisms by which RGS14 gates LTP are largely unexplored. A previous study has attributed the lack of plasticity to higher rates of calcium (Ca2+ ) buffering and extrusion in CA2 spines...
May 2018: ENeuro
https://www.readbyqxmd.com/read/29908432/neochlorogenic-acid-inhibits-against-lps-activated-inflammatory-responses-through-up-regulation-of-nrf2-ho-1-and-involving-ampk-pathway
#5
Sun Young Park, Mei Ling Jin, Eun Hye Yi, Yoon Kim, Geuntae Park
Acute and chronic inflammatory diseases are associated with excessive inflammation due to the accumulation of pro-inflammatory mediators and cytokines produced by macrophages. In the present study, we investigated the anti-inflammatory properties of neochlorogenic acid (nCGA) from Lonicera japonica on lipopolysaccharide (LPS)-activated inflammation in macrophages and participation of the AMPK/Nrf2 pathway. nCGA pretreatment significantly reduced the production of nitric oxide, prostaglandin E2 , TNF-α, reactive oxygen species, IL-1β, and IL-6 by LPS-activated macrophages...
June 8, 2018: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29908234/agmatine-attenuates-methamphetamine-induced-passive-avoidance-learning-and-memory-and-camkii-%C3%AE-gene-expression-deteriorations-in-hippocampus-of-rat
#6
Maryam Noorbakhshnia, Arsham Rashidkaboli, Mahnaz Pakatchian, Siamak Beheshti
Methamphetamine (METH) abuse is one the most worldwide problems with wide-ranging effects on the central nervous system (CNS). Chronic METH abuse can associate with cognitive abnormalities and neurodegenerative changes in the brain. Agmatine, a cationic polyamine, has been proposed as a neuromodulator that modulates many effects of abused drugs. The aim of this study was to determine if agmatine can decrease the impairment effect of METH on memory and hippocampal CaMKII-α gene expression, a gene that plays a major role in memory...
June 13, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29905892/physiological-and-unappreciated-roles-of-camkii-in-the-heart
#7
REVIEW
Jan Beckendorf, Maarten M G van den Hoogenhof, Johannes Backs
In the cardiomyocyte, CaMKII has been identified as a nodal influencer of excitation-contraction and also excitation-transcription coupling. Its activity can be regulated in response to changes in intracellular calcium content as well as after several post-translational modifications. Some of the effects mediated by CaMKII may be considered adaptive, while effects of sustained CaMKII activity may turn into the opposite and are detrimental to cardiac integrity and function. As such, CaMKII has long been noted as a promising target for pharmacological inhibition, but the ubiquitous nature of CaMKII has made it difficult to target CaMKII specifically where it is detrimental...
June 15, 2018: Basic Research in Cardiology
https://www.readbyqxmd.com/read/29903013/inhibition-of-calcium-calmodulin-dependent-kinase-ii-restores-contraction-and-relaxation-in-isolated-cardiac-muscle-from-type-2-diabetic-rats
#8
Lorna J Daniels, Rachel S Wallace, Olivia M Nicholson, Genevieve A Wilson, Fiona J McDonald, Peter P Jones, J Chris Baldi, Regis R Lamberts, Jeffrey R Erickson
BACKGROUND: Calcium/calmodulin-dependent kinase II-delta (CaMKIIδ) activity is enhanced during hyperglycemia and has been shown to alter intracellular calcium handling in cardiomyocytes, ultimately leading to reduced cardiac performance. However, the effects of CaMKIIδ on cardiac contractility during type 2 diabetes are undefined. METHODS: We examined the expression and activation of CaMKIIδ in right atrial appendages from non-diabetic and type 2 diabetic patients (n = 7 patients per group) with preserved ejection fraction, and also in right ventricular tissue from Zucker Diabetic Fatty rats (ZDF) (n = 5-10 animals per group) during early diabetic cardiac dysfunction, using immunoblot...
June 14, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29901626/curcumin-induces-endoplasmic-reticulum-stress-associated-apoptosis-in-human-papillary-thyroid-carcinoma-bcpap-cells-via-disruption-of-intracellular-calcium-homeostasis
#9
Li Zhang, Xian Cheng, Shichen Xu, Jiandong Bao, Huixin Yu
BACKGROUND: Thyroid cancer is the most common endocrine tumor. Our previous studies have demonstrated that curcumin can induce apoptosis in human papillary thyroid carcinoma BCPAP cells. However, the underlined mechanism has not been clearly elucidated. Endoplasmic reticulum (ER) is a major organelle for synthesis, maturation, and folding proteins as well as a large store for Ca. Overcoming chronically activated ER stress by triggering pro-apoptotic pathways of the unfolded protein response (UPR) is a novel strategy for cancer therapeutics...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29898920/wnt7b-through-frizzled-7-receptor-promotes-dendrite-development-by-coactivation-of-camkii-and-jnk
#10
María E Ferrari, María E Bernis, Faye McLeod, Marina Podpolny, Romina P Coullery, Inelia M Casadei, Patricia C Salinas, Silvana B Rosso
The formation of complex dendritic arbors is crucial for the assembly of functional networks as abnormal dendrite formation underlies several neurodevelopmental and psychiatric disorders. Many extracellular factors have been postulated as regulators of dendritic growth. Wnt proteins play a critical role in neuronal development and circuit formation. We previously demonstrated that Wnt7b acts through the scaffold protein Dishevelled (Dvl) to modulate dendrite arborization by activating a Wnt non-canonical signalling pathway...
June 13, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29898386/camkii-metaplasticity-drives-a%C3%AE-oligomer-mediated-synaptotoxicity
#11
Patricio Opazo, Silvia Viana da Silva, Mario Carta, Christelle Breillat, Steven J Coultrap, Dolors Grillo-Bosch, Matthieu Sainlos, Françoise Coussen, K Ulrich Bayer, Christophe Mulle, Daniel Choquet
Alzheimer's disease (AD) is emerging as a synaptopathology driven by metaplasticity. Indeed, reminiscent of metaplasticity, oligomeric forms of the amyloid-β peptide (oAβ) prevent induction of long-term potentiation (LTP) via the prior activation of GluN2B-containing NMDA receptors (NMDARs). However, the downstream Ca2+ -dependent signaling molecules that mediate aberrant metaplasticity are unknown. In this study, we show that oAβ promotes the activation of Ca2+ /calmodulin-dependent kinase II (CaMKII) via GluN2B-containing NMDARs...
June 12, 2018: Cell Reports
https://www.readbyqxmd.com/read/29883672/camk%C3%A2-mediates-cadmium-induced-apoptosis-in-rat-primary-osteoblasts-through-mapk-activation-and-endoplasmic-reticulum-stress
#12
Wei Liu, Chao Xu, Di Ran, Yi Wang, Hongyan Zhao, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Yan Yuan, Zongping Liu
Ca2+ is an important ion in various intracellular metabolic pathways. Endoplasmic reticulum (ER) is a major intracellular calcium store and ER calcium homeostasis plays a key part in the regulation of apoptosis. We have previously shown that Cadmium (Cd) induces apoptosis in osteoblasts (OBs), accompany by increased cytoplasmic calcium. As the role of calcium in OBs apoptosis induced by Cd has not been clarified we investigated the effects of Cd exposure in rat OBs on intracellular Ca2+ , CaMKII phosphorylation, and the pathways implicated in inducing apoptosis...
June 5, 2018: Toxicology
https://www.readbyqxmd.com/read/29881949/ca-2-calmodulin-dependent-protein-kinase-ii-camkii-%C3%AE-dependent-phosphorylation-of-gaba-b1-triggers-lysosomal-degradation-of-gaba-b-receptors-via-mind-bomb-2-mib2-mediated-lys-63-linked-ubiquitination
#13
Khaled Zemoura, Karthik Balakrishnan, Thomas Grampp, Dietmar Benke
The G protein-coupled GABAB receptors, constituted from GABAB1 and GABAB2 subunits, are important regulators of neuronal excitability by mediating long-lasting inhibition. One factor that determines receptor availability and thereby the strength of inhibition is regulated protein degradation. GABAB receptors are constitutively internalized from the plasma membrane and are either recycled to the cell surface or degraded in lysosomes. Lys-63-linked ubiquitination mediated by the E3 ligase Mind bomb-2 (MIB2) is the signal that sorts GABAB receptors to lysosomes...
June 7, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29879878/pure-polyphenols-applications-for-cardiac-health-and-disease
#14
Claudia N Santos, Andreia Gomes, Carole Oudot, Daniela Dias-Pedroso, Ana Rodriguez-Mateos, Helena L A Vieira, Catherine Brenner
Polyphenols are natural compounds present in fruits and vegetables that can exert beneficial effects on human health and notably, on the cardiovascular system. Some of these compounds showed significant protective activities toward atherosclerosis, hypertension, myocardial infarction, anthracyclin-induced cardiomyopathy, angiogenesis as well as heart failure. Polyphenols can act through systemic effects as well as through modulation of signaling pathways such as redox signaling, inflammation, autophagy and cell death in the heart and vessels...
June 7, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29867712/high-frequency-repetitive-magnetic-stimulation-enhances-the-expression-of-brain-derived-neurotrophic-factor-through-activation-of-ca-2-calmodulin-dependent-protein-kinase-ii-camp-response-element-binding-protein-pathway
#15
Ahreum Baek, Eun Jee Park, Soo Yeon Kim, Bae-Geun Nam, Ji Hyun Kim, Sang Woo Jun, Sung Hoon Kim, Sung-Rae Cho
Repetitive transcranial magnetic stimulation (rTMS) can be used in various neurological disorders. However, neurobiological mechanism of rTMS is not well known. Therefore, in this study, we examined the global gene expression patterns depending on different frequencies of repetitive magnetic stimulation (rMS) in both undifferentiated and differentiated Neuro-2a cells to generate a comprehensive view of the biological mechanisms. The Neuro-2a cells were randomly divided into three groups-the sham (no active stimulation) group, the low-frequency (0...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29864081/camkii-activation-promotes-cardiac-electrical-remodeling-and-increases-the-susceptibility-to-arrhythmia-induction-in-high-fat-diet-fed-mice-with-hyperlipidemia-conditions-erratum
#16
(no author information available yet)
No abstract text is available yet for this article.
June 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29860638/characterization-of-fibroblasts-from-hypertrophied-right-ventricle-of-pulmonary-hypertensive-rats
#17
Keisuke Imoto, Muneyoshi Okada, Hideyuki Yamawaki
Pulmonary arterial hypertension (PAH), which is characterized by an elevation of pulmonary arterial resistance, leads to a lethal right heart failure. It is an urgent issue to clarify the pathogenesis of PAH-induced right heart failure. The present study aimed to elucidate the characteristics of cardiac fibroblasts (CFs) isolated from hypertrophied right ventricles of monocrotaline (MCT)-induced PAH model rats. CFs were isolated from the right ventricles of MCT-injected rats (MCT-CFs) and saline-injected control rats (CONT-CFs)...
June 2, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29847775/mechanisms-for-localising-calcineurin-and-camkii-in-dendritic-spines
#18
REVIEW
Christopher J Penny, Matthew G Gold
Calcineurin and calmodulin-dependent protein kinase II (CaMKII) are both highly abundant in neurons, and both are activated by calmodulin at similar Ca2+ concentrations in the test tube. However, they fulfill opposite functions in dendritic spines, with CaMKII activity driving long-term synaptic potentiation following large influxes of Ca2+ through NMDA-type glutamate receptors (NMDARs), and calcineurin responding to smaller influxes of Ca2+ through the same receptors to induce long-term depression. In this review, we explore the notion that precise dynamic localisation of the two enzymes at different sites within dendritic spines is fundamental to this behavior...
May 27, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29846839/curcumin-modulates-the-nmda-receptor-subunit-composition-through-a-mechanism-involving-camkii-and-ser-thr-protein-phosphatases
#19
Cinzia Mallozzi, Mariacristina Parravano, Lucia Gaddini, Marika Villa, Flavia Pricci, Fiorella Malchiodi-Albedi, Andrea Matteucci
Curcumin is one of the major compounds contained in turmeric, the powdered rhizome of Curcuma longa. Results obtained in various experimental models indicate that curcumin has the potential to treat a large variety of neuronal diseases. Excitotoxicity, the toxicity due to pathological glutamate receptors stimulation, has been considered to be involved in several ocular pathologies including ischemia, glaucoma, and diabetic retinopathy. The NMDA receptor (NMDAR), a heteromeric ligand-gated ion channel, is composed of GluN1 and GluN2 subunits...
May 30, 2018: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/29845301/resveratrol-inhibits-angiotensin-ii%C3%A2-induced-proliferation-of-a7r5-cells-and-decreases-neointimal-hyperplasia-by-inhibiting-the-camkii%C3%A2-hdac4-signaling-pathway
#20
Xiaozhen Lin, Chuanfang Cheng, Junyang Zhong, Benrong Liu, Chengfeng Luo, Wenchao Ou, Pei Mo, Qiang Huang, Shiming Liu
Resveratrol has been reported to inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia following arterial injury; however, the underlying mechanisms remain unclear. The present study was designed to investigate the effects of resveratrol on angiotensin II (AngII)‑induced proliferation of A7r5 cells and explore the molecular mechanisms responsible for the observed effects. Resveratrol inhibited cell proliferation and migration, and decreased the AngII‑induced protein expression of α‑smooth muscle actin (α‑SMA), proliferating cell nuclear antigen (PCNA) and cyclin‑dependent kinase 4 (CDK4)...
May 23, 2018: Molecular Medicine Reports
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