Jianhao Wang, Hang Yu, Xiang Li, Fang Li, Hongyu Chen, Xi Zhang, Yamei Wang, Ruifeng Xu, Feng Gao, Jiabei Wang, Pai Liu, Yuke Shi, Dongdong Qin, Yiyi Li, Songyan Liu, Shuai Ding, Xin-Ya Gao, Zhi-Hao Wang
Decreased hippocampal tropomyosin receptor kinase B (TrkB) level is implicated in the pathophysiology of stress-induced mood disorder and cognitive decline. However, how TrkB is modified and mediates behavioral responses to chronic stress remains largely unknown. Here the effects and mechanisms of TrkB cleavage by asparagine endopeptidase (AEP) were examined on a preclinical murine model of chronic restraint stress (CRS)-induced depression. CRS activated IL-1β-C/EBPβ-AEP pathway in mice hippocampus, accompanied by elevated TrkB 1-486 fragment generated by AEP...
March 29, 2024: Brain, Behavior, and Immunity