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https://www.readbyqxmd.com/read/28806109/reflections-on-leadership-and-governance-from-the-incident-manager-of-liberia-s-ebola-response
#1
Tolbert Nyenswah
The 2014-2016 epidemic of Ebola virus disease occurred in a region with a recent history of civil war, unstable health systems, and widespread poverty. Despite these contextual challenges, the national Ebola response in Liberia controlled transmission under strong leadership that was able to rapidly coordinate activities, to manage local and international players, and to adapt upon recognizing missteps. Such leadership has persisted to improve public health capacity in post-Ebola Liberia. This article highlights the progress made toward developing a resilient health security system with capacity to prevent, detect, and respond to disease threats before they reach epidemic level...
August 14, 2017: Health Security
https://www.readbyqxmd.com/read/28806082/the-discovery-of-novel-antimalarial-aminoxadiazoles-as-a-promising-nonendoperoxide-scaffold
#2
Elena Sandoval, María José Lafuente-Monasterio, María J Almela, Pablo Castañeda, María Belén Jiménez Díaz, María S Martínez-Martínez, Jaume Vidal, Íñigo Angulo-Barturen, Paul Bamborough, Jeremy Burrows, Nicholas Cammack, María J Chaparro, José M Coterón, Cristina de Cozar, Benigno Crespo, Beatriz Díaz, Gerard Drewes, Esther Fernández, Santiago Ferrer-Bazaga, María Teresa Fraile, Francisco J Gamo, Sonja Ghidelli-Disse, Rubén Gómez, John Haselden, Sophie Huss, María Luisa León, Jaime de Mercado, Simon J F Macdonald, José Ignacio Martín Hernando, Sara Prats, Margarita Puente, Anne Rodríguez, Juan C de la Rosa, Lourdes Rueda, Carolyn Selenski, Paul Willis, David M Wilson, Michael Witty, Félix Calderón
Since the appearance of resistance to the current front-line antimalarial treatments, ACTs (artemisinin combination therapies), the discovery of novel chemical entities to treat the disease is recognized as a major global health priority. From the GSK antimalarial set, we identified an aminoxadiazole with an antiparasitic profile comparable with artemisinin (1), with no cross-resistance in a resistant strains panel and a potential new mode of action. A medicinal chemistry program allowed delivery of compounds such as 19 with high solubility in aqueous media, an acceptable toxicological profile, and oral efficacy...
August 14, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28805637/wolbachia-mediated-virus-blocking-in-the-mosquito-vector-aedes-aegypti
#3
REVIEW
Gerard Terradas, Elizabeth A McGraw
Viruses transmitted by mosquitoes such as dengue, Zika and West Nile cause a threat to global health due to increased geographical range and frequency of outbreaks. The bacterium Wolbachia pipientis may be the solution reducing disease transmission. Though commonly missing in vector species, the bacterium was artificially and stably introduced into Aedes aegypti to assess its potential for biocontrol. When infected with Wolbachia, mosquitoes become refractory to infection by a range of pathogens, including the aforementioned viruses...
August 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28805465/what-we-are-watching-top-global-infectious-disease-threats-2013-2016-an-update-from-cdc-s-global-disease-detection-operations-center
#4
Kira A Christian, A Danielle Iuliano, Timothy M Uyeki, Eric D Mintz, Stuart T Nichol, Pierre Rollin, J Erin Staples, Ray R Arthur
To better track public health events in areas where the public health system is unable or unwilling to report the event to appropriate public health authorities, agencies can conduct event-based surveillance, which is defined as the organized collection, monitoring, assessment, and interpretation of unstructured information regarding public health events that may represent an acute risk to public health. The US Centers for Disease Control and Prevention's (CDC's) Global Disease Detection Operations Center (GDDOC) was created in 2007 to serve as CDC's platform dedicated to conducting worldwide event-based surveillance, which is now highlighted as part of the "detect" element of the Global Health Security Agenda (GHSA)...
August 14, 2017: Health Security
https://www.readbyqxmd.com/read/28804714/reduction-of-mosquito-survival-in-mice-vaccinated-with-anopheles-stephensi-glucose-transporter
#5
J Couto, S Antunes, J Ferrolho, J de la Fuente, A Domingos
Despite the fact that recent efforts to control/eradicate malaria have contributed to a significant decrease in the number of cases and deaths, the disease remains a global health challenge. Vaccines based on mosquito salivary gland antigens are a potential approach for reducing vector populations and malaria parasites. The Anopheles AGAP007752 gene encodes for a glucose transporter that is upregulated during Plasmodium infection, and its knockdown decreases the number of sporozoites in mosquito salivary glands...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28804465/personality-traits-related-to-binge-drinking-a-systematic-review
#6
REVIEW
Ana Adan, Diego A Forero, José Francisco Navarro
The pattern of alcohol consumption in the form of binge drinking (BD) or heavy episodic drinking has increased notably worldwide in recent years, especially among adolescent and young people, being currently recognized as a global health problem. Although only a minority of binge drinkers will develop a substance use disorder, BD may have negative personal and social consequences in the short and medium term. The objective of this article is to review the findings on personality traits related to binge drinkers and to emphasize the aspects that should be examined in order to make progress in this area...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28803091/depression-a-major-contributor-to-poor-quality-of-life-in-patients-with-advanced-cancer
#7
K S Grotmol, H C Lie, M J Hjermstad, N Aass, D Currow, S Kaasa, T Å Moum, A Pigni, J H Loge
CONTEXT: Quality of life (QoL) and depression are important patient-reported outcomes in cancer care. However, the relative importance of depression severity in predicting QoL remains unclear due to few methodologically sound studies. OBJECTIVES: To examine whether depression contributes to impairment of QoL irrespective of prognostic factors and symptom burden. METHODS: 563 patients were included from the European Palliative Care Research Collaborative Study (EPCRC-CSA), an international, multi-centre, cross-sectional study...
August 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28802412/mycobacterium-tuberculosis-sige-mutant-st28-used-as-a-vaccine-induces-protective-immunity-in-the-guinea-pig-model
#8
JoLynn Troudt, Elizabeth Creissen, Linda Izzo, Helle Bielefeldt-Ohmann, Stefano Casonato, Riccardo Manganelli, Angelo A Izzo
With more than 9 million new infections and 1.5 million deaths claimed every year, tuberculosis remains one of the major scourges of humankind. The only vaccine available against this disease, the attenuated strain Mycobacterium bovis, BCG is effective against severe forms of the disease in infants, but scarcely effective in protecting adults from the pulmonary form of the disease, thus not stopping transmission. Consequently, the development of an effective anti-tuberculosis vaccine is a major goal for improving global health...
September 2017: Tuberculosis
https://www.readbyqxmd.com/read/28802404/enabling-faster-go-no-go-decisions-through-secondary-screens-in-anti-mycobacterial-drug-discovery
#9
REVIEW
Raju Mukherjee, Anup Chandra Pal, Mousumi Banerjee
Management of tuberculosis, already a global health emergency, is becoming increasingly challenging with extensive misuse of second line drugs and their inaccessibility to eighty percent of the eligible patients. Rising statistics of antimicrobial resistance underscores the need for a set of completely new and more effective class of compounds with novel mechanisms of action that can be administered in combination to replace and shorten the present intensive six months regimen. In this review, we stress on the importance and the successes of phenotypic screening for discovery of anti-mycobacterial compound and discuss the importance of performing secondary screens and counter screens to get early estimate on compound's potentials for a successful development...
September 2017: Tuberculosis
https://www.readbyqxmd.com/read/28801790/cardiovascular-disease-the-nitric-oxide-pathway-and-risk-of-cognitive-impairment-and-dementia
#10
REVIEW
Blossom C M Stephan, Stephanie L Harrison, Hannah A D Keage, Abrar Babateen, Louise Robinson, Mario Siervo
PURPOSE OF REVIEW: In this review, we summarise the evidence on the association between cardiovascular disease (CVD) and cognitive impairment and explore the role of the nitric oxide (NO) pathway as a causal mechanism. RECENT FINDINGS: Evidence from epidemiological studies suggests that the presence of CVD and its risk factors in midlife is associated with an increased risk of later life cognitive impairment and dementia. It is unclear what is driving this association but risk may be conveyed via an increase in neurodegeneration (e...
August 11, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28801437/patient-experience-of-nhs-health-checks-a-systematic-review-and-qualitative-synthesis
#11
Juliet A Usher-Smith, Emma Harte, Calum MacLure, Adam Martin, Catherine L Saunders, Catherine Meads, Fiona M Walter, Simon J Griffin, Jonathan Mant
OBJECTIVE: To review the experiences of patients attending NHS Health Checks in England. DESIGN: A systematic review of quantitative and qualitative studies with a thematic synthesis of qualitative studies. DATA SOURCES: An electronic literature search of Medline, Embase, Health Management Information Consortium, Cumulative Index of Nursing and Allied Health Literature, Global Health, PsycInfo, Web of Science, OpenGrey, the Cochrane Library, National Health Service (NHS) Evidence, Google Scholar, Google, Clinical Trials...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801431/socioeconomic-and-geographical-variation-in-general-practitioner-consultations-for-allergic-rhinitis-in-england-2003-2014-an-observational-study
#12
Daniel Todkill, Paul Loveridge, Alex James Elliot, Roger Morbey, Simon de Lusignan, Obaghe Edeghere, Gillian Smith
OBJECTIVE: Allergic rhinitis (AR) is a global health problem, potentially impacting individuals' sleep, work and social life. We aimed to use a surveillance network of general practitioners (GPs) to describe the epidemiology of AR consultations in England. SETTING: A large GP surveillance network covering approximately 53% of the English population. METHODS: GP consultations for AR across England between 30 December 2002 and 31 December 2014 were analysed...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28801008/the-course-of-quality-of-life-and-neurocognition-in-newly-diagnosed-patients-with-glioblastoma
#13
B Flechl, C Sax, M Ackerl, R Crevenna, A Woehrer, J Hainfellner, M Preusser, G Widhalm, B Kiesel, C Lütgendorf-Caucig, K Dieckmann, C Steffal, C Marosi, M R Hassler
BACKGROUND: The importance of QoL and neurocognitive functions in patients with glioblastoma (GB) is above controversy by now. We followed newly diagnosed GB patients treated with radio-chemotherapy during their course of disease by continuously evaluating their quality of life (QoL) and cognitive functions. METHODS: We included consecutive patients with newly diagnosed GB from 2010 to 2013 at the Medical University of Vienna. To assess QoL the EORTC QLQ C30 and BN20 questionnaire were used...
August 8, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28799962/intention-to-receive-breast-cancer-screening-and-related-factors-of-influence-among-vietnamese-women-in-transnational-marriages
#14
Fang-Hsin Lee
BACKGROUND: Breast cancer is a major global health issue. Receivingregular breast cancer screenings aids in the early detection and treatment of breast cancer. Numerous factors influence whether a Vietnamese woman receives breast cancer screening. PURPOSE: The aims of this study were to understand current rates of breast cancer screening and explore the factors that influence intention to undergo breast cancer screening among Vietnamese women in transnational marriages...
August 10, 2017: Journal of Nursing Research: JNR
https://www.readbyqxmd.com/read/28799463/rebuilding-research-capacity-in-fragile-states-the-case-of-a-somali-swedish-global-health-initiative
#15
Abdirisak Ahmed Dalmar, Abdullahi Sheik Hussein, Said Ahmed Walhad, Abdirashid Omer Ibrahim, Abshir Ali Abdi, Mohamed Khalid Ali, Derie Ismail Ereg, Khadra Ali Egal, Abdulkadir Mohamed Shirwa, Mohamed Hussain Aden, Marian Warsame Yusuf, Yakoub Aden Abdi, Lennart Freij, Annika Johansson, Khalif Bile Mohamud, Yusuf Abdulkadir, Maria Emmelin, Jaran Eriksen, Kerstin Erlandsson, Lars L Gustafsson, Anneli Ivarsson, Marie Klingberg-Allvin, John Kinsman, Carina Källestål, Mats Målqvist, Fatumo Osman, Lars-Åke Persson, Klas-Göran Sahlén, Stig Wall
This paper presents an initiative to revive the previous Somali-Swedish Research Cooperation, which started in 1981 and was cut short by the civil war in Somalia. A programme focusing on research capacity building in the health sector is currently underway through the work of an alliance of three partner groups: six new Somali universities, five Swedish universities, and Somali diaspora professionals. Somali ownership is key to the sustainability of the programme, as is close collaboration with Somali health ministries...
2017: Global Health Action
https://www.readbyqxmd.com/read/28798893/complementary-feeding-knowledge-practices-and-dietary-diversity-among-mothers-of-under-five-children-in-an-urban-community-in-lagos-state-nigeria
#16
Foluke Adenike Olatona, Jesupelumi Oreoluwa Adenihun, Sunday Adedeji Aderibigbe, Oluwafunmilayo Funke Adeniyi
BACKGROUND AND OBJECTIVES: Inappropriate complementary feeding is a major cause of child malnutrition and death. This study determined the complementary feeding knowledge, practices, minimum dietary diversity, and acceptable diet among mothers of under-five children in an urban Local Government Area of Lagos State, Southwest Nigeria. METHODS: This descriptive cross-sectional study was conducted in Eti-Osa area of Lagos State, Nigeria. Multi-stage sampling technique was employed to select 355 mothers and infants...
2017: International Journal of MCH and AIDS
https://www.readbyqxmd.com/read/28797498/interventions-to-enhance-testing-linkage-to-care-and-treatment-uptake-for-hepatitis-c-virus-infection-among-people-who-inject-drugs-a-systematic-review
#17
Sahar Bajis, Gregory J Dore, Behzad Hajarizadeh, Evan B Cunningham, Lisa Maher, Jason Grebely
BACKGROUND: The burden of hepatitis C virus (HCV) infection is escalating among people who inject drugs (PWID), yet testing and treatment remains suboptimal. The aim of this systematic review was to evaluate the effectiveness of interventions to enhance HCV testing, linkage to care, and treatment uptake among PWID. METHODS: A systematic literature search of Medline (Ovid 1946 - present), Embase, Global Health, Cochrane Central Register of Controlled Trials, PsycINFO, Clinical Trials Registry, and Web of Science was conducted covering interventional studies published before 20 July 2016...
August 7, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28797299/prevalence-of-antimicrobial-drug-resistant-bacteria-carried-by-in-and-outpatients-attending-a-secondary-care-hospital-in-zambia
#18
Marjolijn M B Nagelkerke, Kapembwa Sikwewa, Dennis Makowa, Irene de Vries, Simon Chisi, J Wendelien Dorigo-Zetsma
OBJECTIVE: Antimicrobial resistance is an increasing global health problem. Very little data on resistance patterns of pathogenic bacteria in low-income countries exist. The aim of this study was to measure the prevalence of antimicrobial drug resistant bacteria carried by in- and outpatients in the resource constraint setting of a secondary care hospital in Zambia. Nasal and rectal samples from 50 in- and 50 outpatients were collected. Patients were randomly selected and informed consent was obtained...
August 10, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28797291/how-canada-can-help-global-adolescent-health-mature
#19
Ashley Vandermorris, Zulfiqar A Bhutta
BACKGROUND: There is an emerging focus on adolescent health within the global health community as we come to recognize that the adolescent years are formative in determining health and health-related behaviours across the life-course. Such attention is not only relevant on the global scale but is imperative in Canada as well. MAIN BODY: This commentary provides a brief review of recent investments targeting global adolescent health and presents five potential avenues for action which emerged out of the recent Canadian Partnership for Women and Children's Health (CanWaCH) Global Adolescent Health conference...
August 10, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28797132/-possibilities-for-universities-to-influence-global-pricing-of-medicines
#20
Philipp Jaehn, Johannes Inhoffen, Jana Scheer, Felix Streicher, Anna Gesine Huhn, Christopher Lance
People in countries of the global south are affected by a unique spectrum of diseases, while costs for health care are a huge burden in the context of poverty. Furthermore, non-communicable diseases increasingly play a role in these countries. The management of translational research, potential clinical applications and marketing of new drugs in Germany is thus getting more and more important for global health. Regarding this, universities have a particular responsibility for two reasons. First, through basic research, they contribute significantly to the development of new medicines...
July 2017: Das Gesundheitswesen
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