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https://www.readbyqxmd.com/read/28319425/overcoming-challenges-in-the-diagnosis-prevention-and-treatment-of-pediatric-drug-resistant-tuberculosis
#1
Sylvie Jonckheree, Jennifer Furin
Drug-resistant tuberculosis (DR-TB) is a growing global health threat and children are especially vulnerable to becoming infected and sick with DR-TB. There is a growing body of evidence on the optimal diagnosis, treatment and prevention of DR-TB in this vulnerable population. Areas covered: A comprehensive review of the literature on DR-TB in children was done using PubMed and Ovid databases up to December 31, 2016. Topic areas covered included diagnosis of DR-TB, treatment of DR-TB-including novel medications and regimens, prevention of DR-TB, community-based care, and stigma/discrimination...
March 20, 2017: Expert Review of Respiratory Medicine
https://www.readbyqxmd.com/read/28319170/antibody-response-against-phop-efficiently-discriminates-among-healthy-individuals-tuberculosis-patients-and-their-contacts
#2
Aurobind Vidyarthi, Nargis Khan, Tapan Agnihotri, Kaneez F Siddiqui, Girish R Nair, Ashish Arora, Ashok K Janmeja, Javed N Agrewala
Tuberculosis continues to be one of the most devastating global health problem. Its diagnosis will benefit in timely initiation of the treatment, cure and therefore reduction in the transmission of the disease. Tests are available, but none can be comprehensively relied on for its diagnosis; especially in TB-endemic zones. PhoP is a key player in Mycobacterium tuberculosis virulence but nothing has been known about its role in the diagnosis of TB. We monitored the presence of anti-PhoP antibodies in the healthy, patients and their contacts...
2017: PloS One
https://www.readbyqxmd.com/read/28318952/glycaemic-variability-in-patients-with-severe-sepsis-or-septic-shock-admitted-to-an-intensive-care-unit
#3
L M Silveira, A Basile-Filho, E A Nicolini, C A M Dessotte, G C S Aguiar, A M Stabile
BACKGROUND: Sepsis is associated with morbidity and mortality, which implies high costs to the global health system. Metabolic alterations that increase glycaemia and glycaemic variability occur during sepsis. OBJECTIVE: To verify mean body glucose levels and glycaemic variability in Intensive Care Unit (ICU) patients with severe sepsis or septic shock. METHOD: Retrospective and exploratory study that involved collection of patients' sociodemographic and clinical data and calculation of severity scores...
March 15, 2017: Intensive & Critical Care Nursing: the Official Journal of the British Association of Critical Care Nurses
https://www.readbyqxmd.com/read/28318428/fostering-the-future-of-health-promotion-as-seen-through-the-message-from-youth-delegates-on-health-promotion-and-sustainable-development
#4
Sara Rodgers
The World Health Organization 9th Global Conference on Health Promotion presented us with the Shanghai Declaration for promoting health in the 2030 Agenda for Sustainable Development. At the same time, the participants of the conference symposium, 'How can youth become future leaders in delivering on the 2030 Agenda for Sustainable Development?' produced the 'Message from Youth Delegates on Health Promotion and Sustainable Development' as its complement. This 'Message from Youth Delegates' outlined pledges of young leaders in health promotion and proposed the necessary steps to ensure the future of health promotion includes more meaningful participation by young people...
March 2017: Global Health Promotion
https://www.readbyqxmd.com/read/28318359/zika-virus-and-eye
#5
Rupesh Agrawal, Hnin Hnin Oo, Praveen Kumar Balne, Lisa Ng, Louis Tong, Yee Sin Leo
Zika virus (ZIKV), a mosquito-borne flavivirus, is the latest global health concern. Transmission is mainly via Aedes mosquitoes and the infection can be diagnosed on molecular or serologic testings. It typically causes a mild self-remitting illness of low-grade fever, maculopapular rash, and myalgia, but when severe, it is associated with neurological deficits and congenital structural defects. Ocular manifestations are usually mild like nonpurulent conjunctivitis in adults, though it may be linked to uveitis, maculopathy, and hypertensive iridocyclitis...
March 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28318108/neonatal-mono-colonization-of-germ-free-mice-with-lactobacillus-casei-enhances-casein-immunogenicity-after-oral-sensitization-to-cow-s-milk
#6
Matieny Aicha Maiga, Stéphanie Morin, Hervé Bernard, Sylvie Rabot, Karine Adel -Patient, Stéphane Hazebrouck
SCOPE: Food allergy is an increasing global health problem and perinatal administration of probiotic bacteria is currently under investigation in order to prevent the development of allergic diseases. Here, we investigated the impact of neonatal mono-colonization of mice with Lactobacillus casei BL23 on an oral sensitization to cow's milk. METHODS AND RESULTS: Mono-colonized (LC) mice were obtained by inoculating L. casei to germ-free (GF) parents. Nine-week-old GF, LC and conventional (CV) mice were orally sensitized to cow's milk with cholera toxin as adjuvant...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28317157/design-and-synthesis-of-novel-anti-plasmodial-histone-deacetylase-inhibitors-containing-an-alkoxyamide-connecting-unit
#7
Leandro A Alves Avelar, Jana Held, Jessica A Engel, Parichat Sureechatchaiyan, Finn K Hansen, Alexandra Hamacher, Matthias U Kassack, Benjamin Mordmüller, Katherine T Andrews, Thomas Kurz
Despite recent declines in mortality, malaria remains an important global health problem. New therapies are needed, including new drugs with novel modes of action compared to existing agents. Among new potential therapeutic targets for malaria, inhibition of parasitic histone deacetylases (HDACs) is a promising approach. Homology modeling of PfHDAC1, a known target of some anti-plasmodial HDAC inhibitors, revealed a unique threonine residue at the rim of the active site in close proximity to the location of the cap group of vorinostat-type HDAC inhibitors...
March 20, 2017: Archiv der Pharmazie
https://www.readbyqxmd.com/read/28314568/health-workers-and-the-weaponisation-of-health-care-in-syria-a-preliminary-inquiry-for-the-lancet-american-university-of-beirut-commission-on-syria
#8
Fouad M Fouad, Annie Sparrow, Ahmad Tarakji, Mohamad Alameddine, Fadi El-Jardali, Adam P Coutts, Nour El Arnaout, Lama Bou Karroum, Mohammed Jawad, Sophie Roborgh, Aula Abbara, Fadi Alhalabi, Ibrahim AlMasri, Samer Jabbour
The conflict in Syria presents new and unprecedented challenges that undermine the principles and practice of medical neutrality in armed conflict. With direct and repeated targeting of health workers, health facilities, and ambulances, Syria has become the most dangerous place on earth for health-care providers. The weaponisation of health care-a strategy of using people's need for health care as a weapon against them by violently depriving them of it-has translated into hundreds of health workers killed, hundreds more incarcerated or tortured, and hundreds of health facilities deliberately and systematically attacked...
March 14, 2017: Lancet
https://www.readbyqxmd.com/read/28314501/legal-and-regulatory-barriers-to-reverse-innovation
#9
Virginia Rowthorn, Alexander J Plum, John Zervos
BACKGROUND: Reverse innovation, or the importation of new, affordable, and efficacious models to high-income countries from the developing world, has emerged as a way to improve the health care system in the United States. Reverse innovation has been identified as a key emerging trend in global health systems in part because low-resourced settings are particularly good laboratories for low-cost/high-impact innovations that are developed out of necessity. A difficult question receiving scant attention is that of legal and regulatory barriers...
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28314499/bringing-global-health-home-the-case-of-global-to-local-in-king-county-washington
#10
EDITORIAL
Adam Taylor, Fareeha Siddiqui
The article describes the experience of testing successful global health interventions in the cities of SeaTac and Tukwila, Washington-2 very diverse, underserved communities outside of Seattle that experience significant health disparities compared with surrounding areas in King County. Topics covered include an overview of the partnership that established Global to Local, the process of engaging Seattle-based global health institutions in identifying global health strategies to test, identifying communities experiencing health disparities that might benefit from global health-inspired interventions, engaging those local communities to understand the perceived drivers of poor health outcomes, tailoring global interventions to the local context, launching programs, and the successes and challenges that have emerged throughout this process...
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28314497/exploring-the-significance-of-bidirectional-learning-for-global-health-education
#11
EDITORIAL
Cristina Redko, Pascal Bessong, David Burt, Max Luna, Samuel Maling, Christopher Moore, Faustin Ntirenganya, Allison N Martin, Robin Petroze, Julia den Hartog, April Ballard, Rebecca Dillingham
No abstract text is available yet for this article.
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28314493/beyond-visas-and-vaccines-preparing-students-for-domestic-and-global-health-engagement
#12
EDITORIAL
Lisa V Adams, Anne N Sosin
At campuses across the United States, scores of students are embarking on global health experiences in low- and middle-income countries. The desire to improve the health of poor communities while preparing for future health careers is often the main driver. The spotlight on domestic health issues also has fueled a resurgence of interest in underserved communities in the United States. Regardless of the destination, rigorous preparation is needed to ensure that the students' presence benefits the communities they aim to serve...
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28314490/service-learning-as-a-framework-for-competency-based-local-global-health-education
#13
EDITORIAL
Tamara McKinnon, Cynthia Toms Smedley, Jessica Evert
No abstract text is available yet for this article.
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28314489/global-health-without-boundaries-structuring-domestic-and-international-opportunities-to-explore-global-health-in-a-graduate-internal-medicine-training-program
#14
EDITORIAL
Marguerite A Balasta, Yogesh Khanal, John McGinniss, Peter Moyer, Tracy L Rabin
No abstract text is available yet for this article.
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28314488/building-sustainable-local-capacity-for-global-health-research-in-west-africa
#15
Nadia A Sam-Agudu, Elijah Paintsil, Muktar H Aliyu, Awewura Kwara, Folasade Ogunsola, Yaw A Afrane, Chima Onoka, Gordon A Awandare, Gladys Amponsah, Llewellyn J Cornelius, Gabou Mendy, Rachel Sturke, Anita Ghansah, George K Siberry, Echezona E Ezeanolue
BACKGROUND: Global health research in resource-limited countries has been largely sponsored and led by foreign institutions. Thus, these countries' training capacity and productivity in global health research is limited. Local participation at all levels of global health knowledge generation promotes equitable access to evidence-based solutions. Additionally, leadership inclusive of competent local professionals promotes best outcomes for local contextualization and implementation of successful global health solutions...
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28314487/the-phi-ghfp-ii-employers-study-the-hidden-barriers-between-domestic-and-global-health-careers-and-crucial-competencies-for-success
#16
Sharon Rudy, Natasha Wanchek, David Godsted, Morgan Blackburn, Elise Mann
BACKGROUND: An ongoing discussion in global health in the United States centers on the future of the US-trained global health workforce and how best to prepare professionals for this career path. The Public Health Institute, through its Global Health Fellows Program (I and II), has been in a unique position to identify the shifting employment dynamic in global health. OBJECTIVES: The purpose of the survey was to gather information on global health employers' hiring practices and insights into the importance of nonclinical skills in contributing to successful professional work; preparedness of graduates with needed nonclinical skills; and the value of domestic work experience for global health careers...
November 2016: Annals of Global Health
https://www.readbyqxmd.com/read/28304402/prospective-longitudinal-study-on-quality-of-life-in-relapsed-refractory-multiple-myeloma-patients-receiving-second-or-third-line-lenalidomide-or-bortezomib-treatment
#17
X Leleu, C Kyriakou, I Vande Broek, P Murphy, P Bacon, P Lewis, H Gilet, B Arnould, M T Petrucci
Treatment advances for multiple myeloma (MM) that have prolonged survival emphasise the importance of measuring patients' health-related quality of life (HRQoL) in clinical studies. HRQoL/functioning and symptoms of patients with relapsed/refractory MM (RRMM) receiving second- or third-line lenalidomide or bortezomib treatment were measured in a prospective European multicentre, observational study at different time points. At baseline, patients in the lenalidomide cohort were frailer than in the bortezomib cohort with more rapid disease progression at study entry (more patients with Eastern Cooperative Oncology Group performance status >2, shorter time from diagnosis, more chronic heart failure, higher serum creatinine levels, more patients with dialysis required)...
March 17, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28303138/importance-of-salmonella-typhi-responsive-cd8-t-cell-immunity-in-a-human-typhoid-fever-challenge-model
#18
Stephanie Fresnay, Monica A McArthur, Laurence S Magder, Thomas C Darton, Claire Jones, Claire S Waddington, Christoph J Blohmke, Brian Angus, Myron M Levine, Andrew J Pollard, Marcelo B Sztein
Typhoid fever, caused by the human-restricted organism Salmonella enterica serovar Typhi (S. Typhi), constitutes a major global health problem. The development of improved attenuated vaccines is pressing, but delayed by the lack of appropriate preclinical models. Herein, we report that high levels of S. Typhi-responsive CD8+ T cells at baseline significantly correlate with an increased risk of disease in humans challenged with a high dose (~10(4) CFU) wild-type S. Typhi. Typhoid fever development was associated with higher multifunctional S...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28302925/best-practices-to-prevent-transmission-and-control-outbreaks-of-hand-foot-and-mouth-disease-in-childcare-facilities-a-systematic-review
#19
REVIEW
J Hy Chan, C K Law, E Hamblion, H Fung, J Rudge
INTRODUCTION: Hand, foot, and mouth disease continues to cause seasonal epidemics in the Asia-Pacific Region. Since the current Enterovirus 71 vaccines do not provide cross-protection for all Enterovirus species that cause hand, foot, and mouth disease, there is an urgent need to identify appropriate detection tools and best practice to prevent its transmission and to effectively control its outbreaks. This systematic review aimed to identify characteristics of outbreak and assess the impact and effectiveness of detection tools and public health preventive measures to interrupt transmission...
March 17, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28302563/introducing-the-lancet-global-health-commission-on-high-quality-health-systems-in-the-sdg-era
#20
Margaret E Kruk, Muhammad Pate, Zoë Mullan
No abstract text is available yet for this article.
March 10, 2017: Lancet Global Health
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