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granulomatous mastitis

Abdel Rahman A Al Manasra, Mohammad F Al-Hurani
BACKGROUND: Mastitis is a common benign disorder of the female breast. It is frequently associated with tenderness, swelling and nipple discharge. We are describing an extremely rare case of an idiopathic granulomatous mastitis in the male breast. Only 1 previous case was reported. CASE REPORT: A 29-year-old male patient presented with a hard, painless lump in the right breast of 2 weeks duration. The patient underwent surgical excision with margin. The histopathologic findings were consistent with granulomatous mastitis...
May 2016: Case Reports in Oncology
Sebahattin Destek, Vahit Onur Gul, Serkan Ahioglu
Idiopathic granulomatous mastitis (IGM) is a rare and chronic inflammatory disorder. IGM mimics breast cancer regarding its clinical and radiological features. Etiology of IGM remains unclarified. Our patient was 37-year-old and 14 weeks pregnant. There was pain, redness and swelling in the right breast. The mass suggestive of malignancy was detected in sonography. Serum CA 125 and CA 15-3 levels were high. Genetic analysis was performed for the etiology. methylenetetrahydrofolate reductase (MTHFR) C 677 TT, β-fibrinogen-455 G>A, plasminogen activator inhibitor (PAI)-1 5 G/5 G, angiotensin-converting enzyme (ACE) I/D mutation was found...
2016: Journal of Surgical Case Reports
Islam A Elzahaby, Ashraf Khater, Adel Fathi, Islam Hany, Mohamed Abdelkhalek, Khaled Gaballah, Amr Elalfy, Omar Hamdy
INTRODUCTION: Idiopathic granulomatous mastitis (IGM) is a chronic inflammatory condition that is confused with cancer. It usually affects women in child bearing age. The exact aetiology and pathogenesis are still unknown, and the optimal therapeutic modality has not yet been established. Treatment most frequently includes Antibiotics, corticosteroids and immunosuppressant, surgical excision, and even mastectomy. MATERIAL AND METHODS: We studied a thirty cases diagnosed with IGM in our locality to find out the leading risk factors and the outcome of our surgical approach which involves excision of the lesion in continuity with duct system...
August 1, 2016: Breast Disease
J Alungal, M C Abdulla, R Narayan
A 25 year-old woman presented with a painful mass in the left breast, polyarthritis and erythema nodosum. Fine needle aspiration cytology led to a diagnosis of granulomatous mastitis. Oral prednisolone rapidly improved the arthritis and the erythema nodosum. Granulomatous mastitis is a very rare, chronic inflammatory disease and only ten patients with granulomatous mastitis with erythema nodosum and polyarthitis have been described.
2016: Reumatismo
Thanaa El A Helal, Lobna S Shash, Somaia A Saad El-Din, Sally M Saber
BACKGROUND: The etiology of idiopathic granulomatous mastitis (IGM) is unknown, and it is commonly misdiagnosed clinically and/or radiologically as breast cancer. The role of fine-needle aspiration cytology (FNAC) in its diagnosis is still a matter of debate. The aim of the current study is to assess the value of FNAC in the diagnosis of IGM, and to search for the presence of bacteria in IGM with cystic vacuoles, which was described recently by a few authors. MATERIALS AND METHODS: Retrospective study of cytologic smears and histologic tissue sections of 65 Egyptian IGM cases was done along with microbiologic testing...
September 9, 2016: Acta Cytologica
Y P Chen, X N Jiang, J P Lu, H Zhang, X Q Li, G Chen
OBJECTIVE: To investigate the clinicopathologic features, diagnosis and differential diagnosis of extranodal Rosai-Dorfman disease(RDD)of the breast. METHODS: Twelve cases of extranodal RDD of the breast were analyzed using hematoxylin-eosin stain and immunohistochemical staining.The morphological features and immunophenotype were observed by light microscopy, accompanied with a review of the literature. RESULTS: Twelve cases of extranodal RDD of the breast are presented...
August 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
J Cheng, Y T Du, H Y Ding
No abstract text is available yet for this article.
August 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
Matthew G Johnson, Sixto Leal, Rongpong Plongla, Peter A Leone, Peter H Gilligan
No abstract text is available yet for this article.
August 2016: Journal of Clinical Microbiology
Matthew G Johnson, Sixto Leal, Rongpong Plongla, Peter A Leone, Peter H Gilligan
No abstract text is available yet for this article.
August 2016: Journal of Clinical Microbiology
Luciana Graziano, Almir Galvão Vieira Bitencourt, Caroline Baptista da Silva, Camila Souza Guatelli, Juliana Alves Souza, Miriam Rosalina Brites Poli, Elvira Ferreira Marques
Idiopathic granulomatous mastitis is a rare disorder of unknown etiology. This disease occurs mostly in young women and often after the lactation period. Women usually present with a fixed, painful mass, sparing the retroareolar region, associated with skin thickening and possible ulceration that mimics carcinoma. Nipple discharge can be present and bilateral involvement may occur in up to 25% of cases. In this case report, we present a typical case of histologically confirmed idiopathic granulomatous mastitis, highlighting the imaging findings, including magnetic resonance imaging (MRI), which may favor this diagnosis and enable better clinical management of these patients...
July 2016: Revista da Associação Médica Brasileira
Thulasi Raman R, D Manimaran
INTRODUCTION: Idiopathic granulomatous lobular mastitis (IGLM) is an inflammatory disease of the breast with an obscure etiology. It occurs mainly in women of reproductive age, and the lesion mimics carcinoma of the breast both clinically and radiologically. CASE PRESENTATION: We present the case of a 29-year-old female who visited our hospital in Kancheepuram, Tamil Nadu, with a 4 × 3 cm lump in the upper outer quadrant of her left breast. The clinical and radiological findings were indicative of a malignant lesion; however, fine-needle aspiration cytology (FNAC) revealed features of granulomatous mastitis, and the subsequent histology of the excised lump confirmed the diagnosis of IGLM...
May 2016: Iranian Red Crescent Medical Journal
Ravza Yilmaz, Ali Aslan Demir, Atilla Kaplan, Dilek Sahin, Enver Ozkurt, Memduh Dursun, Gulden Acunas
PURPOSE: To identify the magnetic resonance imaging (MRI) appearance of idiopathic granulomatous mastitis, and the usefulness of diffusion-weighted magnetic resonance imaging (DW-MRI) in distinguishing idiopathic granulomatous mastitis (IGM) from malignant breast lesions. MATERIAL AND METHODS: A total of 37 women (mean age 36 + 8; range 20-67 years) with histopathologic diagnoses of idiopathic granulomatous mastitis were enrolled in the study. Five patients had bilateral IGM, which were evaluated as ten cases...
July 12, 2016: La Radiologia Medica
Tuğçe Özlem Kalaycı, Melike Bedel Koruyucu, Melda Apaydın, Demet Etit, Makbule Varer
BACKGROUND: Idiopathic granulomatous mastitis (IGM) is an uncommon benign chronic inflammatory breast disease, and erythema nodosum (EN) is an extremely rare systemic manifestation of IGM. Here, we report a rare case of IGM accompanied by EN. CASE REPORT: A 32-year-old patient was admitted to our clinic with a history of a tender mass in the right breast. On physical examination, the right breast contained a hard, tender mass in the lower half with indrawing of the nipple...
March 2016: Balkan Medical Journal
Steven G Allen, Amr S Soliman, Kathleen Toy, Omar S Omar, Tamer Youssef, Mehdi Karkouri, Essam Ayad, Azza Abdel-Aziz, Ahmed Hablas, Ali Tahri, Hanna N Oltean, Celina G Kleer, Sofia D Merajver
Idiopathic granulomatous mastitis (IGM) is a benign, frequently severe chronic inflammatory lesion of the breast. Its etiology remains unknown and reported cases vary in their presentation and histologic findings with an optimal treatment algorithm yet to be described owing mainly to the disease's heterogeneity. IgG4-related disease (IgG4-RD) is a newly recognized systemic fibroinflammatory condition characterized by a dense lymphoplasmacytic infiltrate with many IgG4-positive plasma cells, storiform fibrosis, and obliterative phlebitis...
September 2016: Breast Journal
Megan L Troxell, Nicole T Gordon, J Stone Doggett, Morgan Ballard, John T Vetto, Rodney F Pommier, Arpana M Naik
OBJECTIVES: To determine whether cystic neutrophilic granulomatous mastitis (CNGM) can be associated with Gram-positive bacilli and Corynebacterium METHODS: We reviewed our experience with 35 granulomatous mastitis patients over a 10-year period, including histologic pattern, Gram stain and other microbiologic data, clinical presentation, treatment and outcome. RESULTS: Biopsies from 19 patients demonstrated CNGM, while 16 patients had other patterns of granulomatous mastitis...
May 2016: American Journal of Clinical Pathology
Robert T Fazzio, Sejal S Shah, Nicole P Sandhu, Katrina N Glazebrook
OBJECTIVES: The purpose of this study was to review the imaging features of idiopathic granulomatous mastitis (IGM) with clinical and pathology correlation. METHODS: With institutional review board (IRB) approval, a retrospective search of the surgical pathology database from January 2000 to July 2015 was performed. Clinical, imaging and histology findings were reviewed. Cases of granulomatous mastitis without a known source, diagnosed with percutaneous or surgical biopsy, were included in our analysis...
August 2016: Insights Into Imaging
Yasser S Ahmed, Walid Abd El Maksoud
BACKGROUND: Although idiopathic granulomatous mastitis (IGM) affects young females, its surgical management usually leads to disfigurement of the breasts. OBJECTIVES: To assess the use of therapeutic mammoplasty techniques for management of IGM in terms of recurrence and postoperative patients' satisfaction. METHODS: This prospective clinical study included thirteen patients who were diagnosed histologically as IGM. Patients with moderate to large breasts, who had a breast mass between 20-50% of the breast size with failed medical treatment or intolerability to steroids were subjected to therapeutic mammoplasty techniques...
February 17, 2016: Breast Disease
Smiti Sripathi, Anurag Ayachit, Archana Bala, Rajagopal Kadavigere, Sandeep Kumar
BACKGROUND: Idiopathic granulomatous mastitis is a chronic inflammatory disease of the breast, which is often difficult to differentiate both clinically and radiologically from infectious aetiologies such as tuberculosis, fungal infections, and also from malignancy, thus posing a diagnostic dilemma. We present a pictorial review of the commonly encountered imaging findings in idiopathic granulomatous mastitis on mammography and ultrasound. MATERIALS AND METHODS: Mammographic and ultrasound findings of histopathologically proven cases of granulomatous mastitis are discussed...
August 2016: Insights Into Imaging
Andreas Tauch, Isabel Fernández-Natal, Francisco Soriano
The genus Corynebacterium represents a taxon of Gram-positive bacteria with a high G+C content in the genomic DNA. Corynebacterium kroppenstedtii is an unusual member of this taxon as it lacks the characteristic mycolic acids in the cell envelope. Genome sequence analysis of the C. kroppenstedtii type strain has revealed a lipophilic (lipid-requiring) lifestyle and a remarkable repertoire of carbohydrate uptake and utilization systems. Clinical isolates of C. kroppenstedtii have been obtained almost exclusively from female patients and mainly from breast abscesses and cases of granulomatous mastitis...
July 2016: International Journal of Infectious Diseases: IJID
John R Benson, Dorin Dumitru
Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory condition of the breast which although benign can mimic carcinoma. Establishing a diagnosis can be challenging and requires a high index of suspicion with exclusion of infective and autoimmune breast diseases. IGM is characterized histologically by noncaseating granulomas which are of a lobulo-centric pattern and often associated with microabscess formation. Management of confirmed cases remains controversial with proponents of initial surgical or medical therapies - each has its associated problems which can be worse than the original symptoms of IGM...
June 2016: Future Oncology
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