keyword
https://read.qxmd.com/read/38529282/immune-pathogenesis-of-idiopathic-granulomatous-mastitis-from-etiology-toward-therapeutic-approaches
#1
REVIEW
Xiaoli Wang, Xiujing He, Junzhi Liu, Haiyan Zhang, Hangyu Wan, Jing Luo, Jiqiao Yang
Idiopathic granulomatous mastitis (IGM) is a noncancerous, chronic inflammatory disorder of breast with unknown causes, posing significant challenges to the quality of life due to its high refractoriness and local aggressiveness. The typical symptoms of this disease involve skin redness, a firm and tender breast mass and mastalgia; others may include swelling, fistula, abscess (often without fever), nipple retraction, and peau d'orange appearance. IGM often mimics breast abscesses or malignancies, particularly inflammatory breast cancer, and is characterized by absent standardized treatment options, inconsistent patient response and unknown mechanism...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38488700/is-poor-oral-health-a-risk-factor-for-idiopathic-granulomatous-mastitis
#2
JOURNAL ARTICLE
Semih Sağlık, Enver Ay, Şilan Bilek Olgaç, Necip Nas, Bilal Altunışık
Idiopathic granulomatous mastitis (IGM) is a rare inflammatory breast disease that can be clinically and radiologically mistaken for carcinoma. Although its etiology remains uncertain, potential associations with pregnancy, lactation, hormonal imbalances, autoimmunity, smoking, and various microorganisms have been suggested. This study aimed to evaluate the relationship between IGM and oral health. We included 42 female patients diagnosed with IGM based on histopathological evaluations conducted between September 2018 and October 2023...
March 14, 2024: Biomol Biomed
https://read.qxmd.com/read/38479797/ultrasound-guided-vacuum-assisted-excision-for-idiopathic-granulomatous-mastitis-at-the-abscess-stage
#3
JOURNAL ARTICLE
Hangyu Wan, Haiyan Zhang, Shaolan Yu, Yan Wang, Feng Yang, Jing Luo
BACKGROUND: Idiopathic granulomatous mastitis (IGM) is a rare inflammatory disease of the breast with clinical features that are often confused with those of breast cancer leading to delayed diagnosis and treatment. This retrospective study aimed to evaluate the therapeutic effectiveness and cosmetic results of drainage surgery using ultrasound-guided vacuum-assisted excision (VAE) for the treatment of IGM at the abscess stage. METHODS: The time of recovery, cases of further surgical intervention, and cosmetic results were retrospectively collected and analyzed from patients who underwent drainage with VAE or conventional drainage between October 2017 and August 2021...
March 13, 2024: World Journal of Surgery
https://read.qxmd.com/read/38476604/granulomatous-mastitis-in-accessory-breast-tissue-a-rare-presentation-and-surgical-management
#4
Abdulwahid M Salih, Lana Rα Pshtiwan, Shaban Latif, Halkawt O Ali, Ari M Abdullah, Hiwa O Baba, Jihad Ibrahim Hama, Shko H Hassan, Marwan N Hassan, Shvan H Mohammed, Mohammed L Ahmed, Fahmi H Kakamad
Granulomatous mastitis (GM) in accessory breast tissue is rare. The present study aimed to report a rare case of GM in accessory breast tissue. A 39-year-old female patient presented with right axillary discomfort and swelling for ~5 days. On clinical examination, a tender, firm lump was detected in the right axillary region. The ultrasound showed diffuse parenchymal heterogeneity and surrounding edema in the right accessory breast associated with reactive axillary lymph nodes. Following unresponsiveness to conservative treatment, a surgical procedure was performed in the form of an excisional biopsy and the lesion was diagnosed as GM...
April 2024: Biomedical Reports
https://read.qxmd.com/read/38475841/treatment-modalities-for-granulomatous-mastitis-seeking-the-most-appropriate-treatment-with-the-least-recurrence-rate-a-systematic-review-and-meta-analysis
#5
JOURNAL ARTICLE
Roham Sarmadian, Fatemeh Safi, Hossein Sarmadian, Maryam Shokrpour, Amir Almasi-Hashiani
BACKGROUND: Granulomatous mastitis (GM) is a rare, benign, inflammatory breast disease with an unknown etiology that predominantly affects women of reproductive age. The definitive treatment of GM is currently controversial; an appropriate therapeutic strategy has yet to be identified, and the disease's high recurrence rate remains. This study aims to determine the recurrence rate for each GM treatment strategy to identify the most appropriate treatment modality. METHODS: The search for relevant articles was undertaken using three international databases, including Medline, Scopus, and Web of Science...
March 12, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38455353/staged-operation-in-the-surgical-treatment-of-granulomatous-lobular-mastitis
#6
JOURNAL ARTICLE
Lu Xie, Wenchao Qu, Jiamei Feng, Shijun Shao, Qingqian Gao, Jiaye Sun, Huili Tang, Hua Wan, Xueqing Wu
BACKGROUND: Granulomatous lobular mastitis (GLM) is a chronic inflammatory breast condition characterized by an unclear etiology and an undefined therapeutic approach. Surgical intervention is considered an alternative modality for managing GLM. Staged operation is the predominant and characteristic surgical approach in the treatment of GLM in our center; therefore, we evaluated the efficacy of staged operative techniques in this cohort study. METHODS: We retrospectively reviewed 212 patients with GLM who underwent staged operation between August 2020 and July 2022 in the inpatient department of our institute...
February 29, 2024: Gland Surgery
https://read.qxmd.com/read/38452928/cystic-neutrophlic-granulomatous-mastitis-in-pregnancy
#7
EDITORIAL
John C Kingdom, Jeannie Richardson, Gary Ko, Ralph George
No abstract text is available yet for this article.
March 5, 2024: Journal of Obstetrics and Gynaecology Canada: JOGC
https://read.qxmd.com/read/38416935/demographic-and-socioeconomic-risk-factors-for-granulomatous-mastitis-in-the-united-states-a-case-control-study
#8
JOURNAL ARTICLE
Nina Capiro, Priyanka Naik, Amanda Lo, James Sayre, Magda Shaheen, Mariam Thomas, Antoinette Roth
OBJECTIVE: Granulomatous mastitis (GM) is a benign breast disease that can have an extended clinical course impacting quality of life and causing breast disfigurement. Granulomatous mastitis has been studied throughout the world; however, less is known about GM patients in the United States. We aim to identify demographic and socioeconomic factors associated with GM in the United States. METHODS: An IRB-approved retrospective case-control study was performed of 92 patients with biopsy-proven GM at two institutions in Los Angeles, California: a safety-net hospital and an academic institution...
March 20, 2023: Journal of breast imaging
https://read.qxmd.com/read/38409976/recurrent-idiopathic-granulomatous-mastitis-a-case-report
#9
JOURNAL ARTICLE
Janardan Prasad Joshi, Lila Joshi, Hira Joshi, Ashok Prasad Sah, Thaneshor Neupane
UNLABELLED: Idiopathic granulomatous mastitis is a rare benign breast disease of unknown aetiology mostly presenting as a breast abscess but not responding to usual conservative management with incision and drainage and frequently mimics breast cancer. We present a case 31-year-old female presented with complaints of right breast pain and redness who was initially diagnosed and treated as a case of breast abscess with repeated incision and drainage and antibiotics but did not improve...
February 24, 2024: JNMA; Journal of the Nepal Medical Association
https://read.qxmd.com/read/38389951/a-case-of-idiopathic-granulomatous-mastitis-associated-with-erythema-nodosum
#10
JOURNAL ARTICLE
Nicole Ufkes, Spencer Bertoch
No abstract text is available yet for this article.
March 2024: International Journal of Women's Dermatology
https://read.qxmd.com/read/38372343/refractory-and-recurrent-idiopathic-granulomatous-mastitis-treatment-adaptive-randomized-clinical-trial
#11
JOURNAL ARTICLE
Fatemeh Shojaeian, Shahpar Haghighat, Fereshteh Abbasvandi, Alireza Houshdar Tehrani, Niki Najar Najafi, Ashkan Zandi, Asiie Olfatbakhsh, Maryam Sharifi, Esmat Hashemi, Nahid Nafissi, Safa Najafi
BACKGROUND: Idiopathic Granulomatous Mastitis (IGM) is mostly described as an autoimmune disease with high prevalence among Middle Eastern childbearing-age women. The current study aimed to evaluate the best treatment of choice in patients with resistant or recurrent IGM. STUDY DESIGN: Patients with established recurrent or resistant IGM who were referred to the breast cancer research center from 2017 to 2020 were randomly assigned to either one of the following treatment groups: A (Best supportive care), B (corticosteroids: prednisolone), and C (methotrexate and low dose corticosteroids)...
February 19, 2024: Journal of the American College of Surgeons
https://read.qxmd.com/read/38371511/pathological-manifestations-of-granulomatous-lobular-mastitis
#12
REVIEW
Leyin Cui, Chenping Sun, Jierong Guo, Xuliu Zhang, Sheng Liu
Granulomatous lobular mastitis (GLM) is a rare inflammatory breast disease with unknown etiology, characterized by non-caseous granulomatous inflammation of the lobules, which infiltrate lymphocytes, neutrophils, plasma cells, monocytes, and eosinophils may accompany. GLM is often misdiagnosed as breast cancer due to the lack of specificity in clinical and imaging examinations, and therefore histopathology is the main basis for confirming the diagnosis. This review provides an overview of the pathological features of granulomatous lobular mastitis and cystic neutrophil granulomatous mastitis (CNGM, a pathologic subtype of GLM)...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38327174/cat-scratch-disease-of-the-breast-axilla-recognition-of-a-rare-disease-and-approaches-for-differential-diagnosis
#13
JOURNAL ARTICLE
Jing Wang, Mingfei Yan, Philip Bomeisl, Sarah Sree Cherian, Hannah Gilmore, Ruba Khattab, Aparna Harbhajanka
Cat scratch disease rarely presents as a breast or axillary mass mimicking carcinoma both clinically and radiologically. Diagnosing breast/axillary cat scratch disease is challenging due to its rarity and nonspecific findings. Here, we reported 2 patients with breast cat scratch disease and reviewed 14 patients with cat scratch disease involving breast/axilla from the past 30 years. It mainly affects women (median age: 48), consistently presenting as axillary lymphadenopathy, and demonstrates ipsilateral breast mass in half of patients (50%, 8/16)...
February 7, 2024: International Journal of Surgical Pathology
https://read.qxmd.com/read/38323114/construction-of-a-multi-indicator-model-for-abscess-prediction-in-granulomatous-lobular-mastitis-using-inflammatory-indicators
#14
JOURNAL ARTICLE
Nan-Nan Du, Jia-Mei Feng, Shi-Jun Shao, Hua Wan, Xue-Qing Wu
BACKGROUND: Granulomatous lobular mastitis (GLM) is a chronic inflammatory breast disease, and abscess formation is a common complication of GLM. The process of abscess formation is accompanied by changes in multiple inflammatory markers. The present study aimed to construct a diagnosis model for the early of GLM abscess formation based on multiple inflammatory parameters. METHODS: Based on the presence or absence of abscess formation on breast magnetic resonance imaging (MRI), 126 patients with GLM were categorised into an abscess group (85 patients) and a non-abscess group (41 patients)...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38313639/granulomatous-mastitis-in-a-50-year-old-male-a-case-report-and-review-of-literature
#15
Le-Yin Cui, Chen-Ping Sun, Yun-Yuan Li, Sheng Liu
BACKGROUND: Granulomatous mastitis (GM) an inflammatory disease of the breast that usually affects women of childbearing age, occurs very rarely in males. CASE SUMMARY: We present a case study of a 50-year-old male patient with GM. The patient developed a breast lump following the cleaning of a previously embedded dirt-filled nipple. While an initial improvement was noted with antibiotic therapy, a recurrence occurred a year later, showing resistance to the previously effective antibiotics...
January 16, 2024: World Journal of Clinical Cases
https://read.qxmd.com/read/38308027/imaging-spectrum-in-tropical-breast-infections
#16
JOURNAL ARTICLE
Ekta Dhamija, Shrea Gulati, Smriti Hari
While breast carcinoma is the most feared pathology in women with breast lumps, infections continue to be an important aetiology, especially in countries with low to middle socio-economic status. The breast infections or mastitis can present as acute painful breast or recurrent episodes of breast lumps with or without pain. The common causes include puerperal, non-puerperal, and idiopathic mastitis whereas uncommon causes like tuberculosis, filariasis, hydatid and other parasitic infections are still seen in developing countries...
February 2, 2024: British Journal of Radiology
https://read.qxmd.com/read/38304866/idiopathic-granulomatous-mastitis
#17
REVIEW
Christina Dilaveri, Amy Degnim, Christine Lee, Daniel DeSimone, Dan Moldoveanu, Karthik Ghosh
Idiopathic granulomatous mastitis (IGM) is a rare, benign inflammatory disorder of the breast that is often underrecognized. The exact etiology and pathophysiology are unknown, but milk stasis is felt to play a role. Classically, this condition is noninfectious, but many cases are noted to be associated with Corynebacterium species. Most patients affected are parous women with a mean age of 35, and many have breastfed within five years of diagnosis. Patients typically present with a painful mass and symptoms of inflammation, and these features can sometimes mimic breast cancer...
2024: Breast Journal
https://read.qxmd.com/read/38223282/clindamycin-an-effective-treatment-for-granulomatous-mastitis-caused-by-corynebacterium-kroppenstedtii-in-a-pregnant-patient
#18
JOURNAL ARTICLE
Elmustafa Abdalla, Ahmed Elmudathir, Ahmed H Ahmed, Bashir Ali, Mohamed Elhadi Ali, Noheir M Taha, Fahmi Y Khan
UNLABELLED: Corynebacterium spp. are Gram-positive bacteria, and recent studies have proposed a potential link between granulomatous mastitis and Corynebacterium kroppenstedtii infections, posing a challenge in selecting appropriate antibiotics, particularly in pregnant women. A young pregnant woman presented with a palpable lump in her left breast. Subsequent assessment revealed the presence of necrotising granulomatous mastitis attributed to C. kroppenstedtii . Initially treated with amoxicillin/clavulanate, the patient showed no improvement...
2024: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/38217923/a-single-center-experience-with-a-rare-clinical-entity-of-idiopathic-granulomatous-mastitis-case-series-and-review-of-the-literature
#19
JOURNAL ARTICLE
Aseel Musleh, Oadi N Shrateh, Nima Ishtaya, Khaled Abbadi, Malvina Asbah, Sahar Ayyad
INTRODUCTION AND IMPORTANCE: Idiopathic granulomatous mastitis (IGM), also called autoimmune mastitis or granulomatous lobular mastitis is a benign, rare disease of the breast lobules. It is characterized by chronic non-caseating granulomatous sterile inflammation of the breast lobules. It is a disease of middle-aged women. CASE SERIES PRESENTATION: Herein we report six cases of IGM the General Surgery Department at Palestinian Medical Complex (PMC) with a good response to treatment and significant improvement...
January 11, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38187102/treatment-of-granulomatous-mastitis-with-steroids-should-the-decision-to-end-the-treatment-be-made-radiologically
#20
JOURNAL ARTICLE
Kenan Çetin, Hasan Ediz Sıkar, Fatih Feratoğlu, Bağış Taşdoğan, Bahadır M Güllüoğlu
OBJECTIVE: Idiopathic granulomatous mastitis (IGM) is a benign inflammatory breast disease of unknown etiology that affects women in their reproductive period. The most commonly preferred option as first-line treatment is steroids, but the lack of a standard treatment protocol and high recurrence rate after treatment constitutes a recurring challenge during its management. The aim of this study was to investigate whether the decision to end the treatment should be made radiologically or clinically...
January 2024: European Journal of Breast Health
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