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Tif 1 NXP

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https://www.readbyqxmd.com/read/24670134/comparison-of-radioimmunoprecipitation-versus-antigen-specific-assays-for-identification-of-myositis-specific-autoantibodies-in-dermatomyositis-patients
#1
COMPARATIVE STUDY
Eun Ha Kang, Masataka Kuwana, Yuka Okazaki, Eun Young Lee, Yun Jong Lee, Eun Bong Lee, Yeong Wook Song
BACKGROUND: To confirm the antigen specificities of autoantibodies that precipitate 140-kDa (anti-p140) or 155/140-kDa polypeptides (anti-p155/140) previously identified by radioimmunoprecipitation in Korean patients with dermatomyositis (DM) and to look into the relationship between each MSA and clinical features of DM. METHODS: Seventeen serum samples of classic DM patients who had been found to have either anti-p140 antibodies (n = 9) or anti-p155/140 (n = 8) antibodies in our previous study were examined using enzyme-linked immunosorbent assay (for anti-MDA5 antibodies) and immunoblotting (for anti-MJ/NXP-2 and anti-TIF-1γ antibodies)...
November 2014: Modern Rheumatology
https://www.readbyqxmd.com/read/24037894/most-patients-with-cancer-associated-dermatomyositis-have-antibodies-to-nuclear-matrix-protein-nxp-2-or-transcription-intermediary-factor-1%C3%AE
#2
David F Fiorentino, Lorinda S Chung, Lisa Christopher-Stine, Lisa Zaba, Shufeng Li, Andrew L Mammen, Antony Rosen, Livia Casciola-Rosen
OBJECTIVE: Since dermatomyositis (DM) is associated with an increased risk of malignancy, accurate identification of patients likely to harbor cancers is important. Using immunoprecipitations from radiolabeled cell lysates, several groups recently showed that anti-transcription intermediary factor 1γ (anti-TIF-1γ) antibodies are associated with malignancy in DM. We undertook this study to develop sensitive, specific assays to detect antibodies against TIF-1γ and nuclear matrix protein NXP-2 and to evaluate their association with malignancy in DM...
November 2013: Arthritis and Rheumatism
https://www.readbyqxmd.com/read/20655695/-how-can-we-diagnose-and-better-understand-inflammatory-myopathies-the-usefulness-of-auto-antibodies
#3
Jean Sibilia, Emmanuel Chatelus, Alain Meyer, Jacques-Eric Gottenberg, Christelle Sordet, Joëlle Goetz
The inflammatory myopathies are a group of quite proteiform, systemic auto-immune diseases which include polymyositis, dermatomyositis and inclusion body myopathies. To facilitate the diagnosis, classification criteria (Bohan and Peter, 1975) have been proposed, based essentially on clinical criteria. In addition, over the past fifteen years, auto-antibodies characterizing certain forms of inflammatory myopathy have been identified. One distinguishes schematically: auto-antibodies specific for myositis and auto-antibodies sometimes associated with myositis...
October 2010: La Presse Médicale
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