keyword
https://read.qxmd.com/read/38206575/synthesis-theoretical-and-experimental-investigation-of-electronic-properties-of-new-fluoranthenyl-based-compounds-for-oleds-applications
#21
JOURNAL ARTICLE
Younes Bennacer, Mounia Guergouri, Rafik Bensegueni, Mehdi Boutebdja, Abdelmadjid Kherrouba
Three novel conjugated molecules have been synthesized: 2-(fluoranthen-3-yliminomethyl)-3,4-ethylenedioxythio-phene (EIF), 2-(fluoranthen-3-yliminomethyl)thiophene (TIF), and 2-(fluoranthen-3-yliminomethyl)fluorene (FIF). Optical properties were obtained from electronic absorption and emission spectra in DMSO solution. The solvatochromic properties of the molecules have been studied in different solvents. Electrochemical properties were studied by cyclic voltammetry in a Bu4NBF4 (0.1 M)/MeCN organic solution...
January 11, 2024: ChemPlusChem
https://read.qxmd.com/read/38205217/deep-rna-sequencing-of-muscle-tissue-reveals-absence-of-viral-signatures-in-dermatomyositis
#22
JOURNAL ARTICLE
Victor M Corman, Corinna Preusse, Julia Melchert, Olivier Benveniste, Randi Koll, Hans-Hilmar Goebel, Terry C Jones, Christian Drosten, Ulrike Schara-Schmidt, Sarah Leonard-Louis, Werner Stenzel, Josefine Radke
Objective : To explore a possible connection between active viral infections and manifestation of dermatomyositis (DM). Methods: Skeletal muscle biopsies were analyzed from patients diagnosed with juvenile (n=10) and adult (n=12) DM. Adult DM patients harbored autoantibodies against either TIF-1γ (n=7) or MDA5 (n=5). Additionally, we investigated skeletal muscle biopsies from non-diseased controls (NDC, n=5). We used an unbiased high-throughput RNA sequencing (HTS) approach to detect viral sequences. To further increase sequencing depth, a host depletion approach was applied...
January 2024: Free neuropathology
https://read.qxmd.com/read/38192494/claudin-2-mediates-the-proximal-tubular-epithelial-cell-fibroblast-crosstalk-via-paracrine-ctgf
#23
JOURNAL ARTICLE
Congcong Guo, Mingwen Jiao, Yuying Cui, Pingjiang Li, Jinming Yao, Jianjun Dong, Lin Liao
PURPOSE: Proximal tubular epithelial cell (PTEC) is vulnerable to injury in diabetic kidney disease (DKD) due to high energy expenditure. The injured PTECs-derived profibrotic factors are thought to be driving forces in tubulointerstitial fibrosis (TIF) as they activate surrounding fibroblasts. However, the mechanisms remain unclear. METHODS: The diabetes with uninephrectomy (DKD) rats were used to evaluated renal histological changes and the expression of Claudin-2 by immunofluorescence staining...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38188922/transoral-incisionless-fundoplication-with-or-without-hiatal-hernia-repair-for-gastroesophageal-reflux-disease-after-peroral-endoscopic-myotomy
#24
JOURNAL ARTICLE
John M DeWitt, Mohammad Al-Haddad, Sarah Stainko, Anthony Perkins, Hala Fatima, DuyKhanh P Ceppa, Thomas J Birdas
Background and study aims Gastroesophageal reflux disease (GERD) following peroral endoscopic myotomy (POEM) occurs in 40% to 60% of patients. There are limited data evaluating antireflux surgery or transoral incisionless fundoplication (TIF) for refractory post-POEM GERD. Patients and methods In a single-center prospective cohort study, consecutive patients with medically refractory post-POEM regurgitation and/or GERD treated with TIF or combined laparoscopic hernia repair and TIF (cTIF) were evaluated. Baseline evaluation: GERD-Health Related Quality of Life (GERD-HQRL) and Reflux Symptom Questionnaire 7-day recall (RESQ-7) questionnaires, EGD, high-resolution manometry (HRM), 48-hour pH test off proton pump inhibitors (PPIs) and impedance planimetry of the esophagogastric junction (EGJ) to calculate the diameter distensibility index (EGJ-DI)...
January 2024: Endoscopy International Open
https://read.qxmd.com/read/38187626/metabolite-profiling-of-human-renal-cell-carcinoma-reveals-tissue-origin-dominance-in-nutrient-availability
#25
Keene L Abbott, Ahmed Ali, Bradley I Reinfeld, Amy Deik, Sonu Subudhi, Madelyn D Landis, Rachel A Hongo, Kirsten L Young, Tenzin Kunchok, Christopher S Nabel, Kayla D Crowder, Johnathan R Kent, Maria Lucia L Madariaga, Rakesh K Jain, Kathryn E Beckermann, Caroline A Lewis, Clary B Clish, Alexander Muir, W Kimryn Rathmell, Jeffrey C Rathmell, Matthew G Vander Heiden
The tumor microenvironment is a determinant of cancer progression and therapeutic efficacy, with nutrient availability playing an important role. Although it is established that the local abundance of specific nutrients defines the metabolic parameters for tumor growth, the factors guiding nutrient availability in tumor compared to normal tissue and blood remain poorly understood. To define these factors in renal cell carcinoma (RCC), we performed quantitative metabolomic and comprehensive lipidomic analyses of tumor interstitial fluid (TIF), adjacent normal kidney interstitial fluid (KIF), and plasma samples collected from patients...
December 24, 2023: bioRxiv
https://read.qxmd.com/read/38164021/microrna-26a-alleviates-tubulointerstitial-fibrosis-in-diabetic-kidney-disease-by-targeting-par4
#26
JOURNAL ARTICLE
Gaoting Qu, Xingyue Li, Ran Jin, Dian Guan, Jialing Ji, Shanwen Li, Huimin Shi, Pingfan Tong, Weihua Gan, Aiqing Zhang
Our previous study found that miR-26a alleviates aldosterone-induced tubulointerstitial fibrosis (TIF). However, the effect of miR-26a on TIF in diabetic kidney disease (DKD) remains unclear. This study clarifies the role and possible mechanism of exogenous miR-26a in controlling the progression of TIF in DKD models. Firstly, we showed that miR-26a was markedly decreased in type 2 diabetic db/db mice and mouse tubular epithelial cells (mTECs) treated with high glucose (HG, 30 mM) using RT-qPCR. We then used adeno-associated virus carrying miR-26a and adenovirus miR-26a to enhance the expression of miR-26a in vivo and in vitro...
January 2, 2024: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/38154994/care-of-injured-children-compared-to-adults-at-district-and-regional-hospitals-in-ghana-and-the-impact-of-a-trauma-intake-form-a-stepped-wedge-cluster-randomized-trial
#27
JOURNAL ARTICLE
Adam Gyedu, Adamu Issaka, Anthony Baffour Appiah, Peter Donkor, Charles Mock
BACKGROUND: This study aimed to determine the effectiveness of a standardized trauma intake form (TIF) to improve achievement of key performance indicators (KPIs) of initial trauma care among injured children, compared to adults, at non-tertiary hospitals in Ghana. METHODS: A stepped-wedge cluster randomized trial was performed with research assistants directly observing the management of injured patients before and after introducing the TIF at emergency units of 8 non-tertiary hospitals for 17...
December 10, 2023: Journal of Pediatric Surgery
https://read.qxmd.com/read/38148285/mri-based-interstitial-fluid-velocity-analysis-for-drug-delivery-efficiency-evaluation-in-tumor
#28
JOURNAL ARTICLE
Fangfei He, Xiaohan Zhou, Junwei Cheng, Peisen Zhang, Jun Zhao, Yan Liang, Yi Hou, Wentao Liu, Dong Han
There are many flow behaviors in solid tumors, including intravascular, bloodstream, and interstitial convection. Studies have shown that tumor interstitial fluid (TIF) is an important part of tumor microenvironment regulation and affects drug delivery and metabolism between tumor cells. Magnetic resonance imaging (MRI) is suitable for detecting the flow rates of liquids in tissues. Clinical phase contrast PC-MRI technology has been designed to observe the blood flow in large vessels such as arteries and veins; however, it is not sensitive enough to deal with slow flow velocity...
December 26, 2023: Analytical Chemistry
https://read.qxmd.com/read/38078112/genome-wide-analysis-of-the-tify-family-and-function-of-catify7-and-catify10b-under-cold-stress-in-pepper-capsicum-annuum-l
#29
JOURNAL ARTICLE
Xiaodi Wang, Ning Li, Tianxiang Zan, Kai Xu, Shenghua Gao, Yanxu Yin, Minghua Yao, Fei Wang
TIFY [TIF(F/Y)XG] proteins are a plant particular transcription factor family that regulates plant stress responses. Therefore, to fill this gap, we investigated CaTIFY genes in pepper. Gene structure and conserved motifs of the pepper TIFY gene family were systematically analyzed using sequence alignment analysis, Cis -acting element analysis, transcriptomic data, and RT-qPCR analysis, and their expression patterns were further analyzed using Virus-Induced Gene Silencing (VIGS) and cold stress reactive oxygen species (ROS) response...
2023: Frontiers in Plant Science
https://read.qxmd.com/read/38072665/discovery-of-prdm16-mediated-trpa1-induction-as-the-mechanism-for-low-tubulo-interstitial-fibrosis-in-diabetic-kidney-disease
#30
JOURNAL ARTICLE
Fang Xu, Hongwei Jiang, Xiaozhou Li, Jian Pan, Huiling Li, Luxiang Wang, Pan Zhang, Junxiang Chen, Shuangfa Qiu, Yuxin Xie, Yijian Li, Dongshan Zhang, Zheng Dong
The pathogenesis of Diabetic kidney disease(DKD) involves pathological changes in both tubulo-interstitium and the glomerulus. Surprisingly, tubulo-interstitial fibrosis (TIF), does not develop significantly until the late stage of DKD. Here, it is demonstrated that PR domain-containing 16 (PRDM16) is a key to the low level of TIF in DKD. In the experiments, PRDM16 is upregulated in high glucose-treated renal tubular cells, DKD mouse kidneys, and renal biopsy of human DKD patients via activation of NF-κB signal pathway...
December 10, 2023: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38060701/coexistence-of-autoimmune-pulmonary-alveolar-proteinosis-with-small-cell-lung-cancer-in-a-man-presenting-with-acute-onset-respiratory-failure
#31
Ourania Papaioannou, Electra Koulousousa, Theodoros Karampitsakos, Argyrios Tzouvelekis
A 60-year-old man was referred to our Respiratory Department with progressive dyspnea on exertion and productive cough over the past two months. High-resolution computed tomography showed diffuse ground glass opacities with superimposed interlobular and intralobular septal thickening mainly in the middle and lower lobes, compatible with crazy paving pattern. Serology tests revealed positive antibody transcriptional intermediary factor-γ1 (TIF-1γ) in myositis panel and bronchoalveolar lavage revealed milky appearance and positive periodic acid-Schiff (PAS) stain...
November 2023: Curēus
https://read.qxmd.com/read/38041268/compensation-of-the-tool-influence-function-changes-under-neighborhood-effect-in-atmospheric-pressure-plasma-processing
#32
JOURNAL ARTICLE
Peng Ji, Duo Li, Yuan Jin, Xing Su, Bo Wang
Nowadays, computer controlled optical surfacing (CCOS) is greatly developed in the fabrication of ultra-precision optical surfaces. As one of the deterministic CCOS techniques, atmospheric pressure plasma processing (APPP) can achieve the efficient removal based on the chemical reaction. In this process, the temperature rising issue caused by plasma heating is of great importance for accelerating the etching rate, but also increases the difficulty of deterministic removal control, because the tool influence function (TIF) in APPP is no longer time-invariant...
November 20, 2023: Optics Express
https://read.qxmd.com/read/38028105/dermatomyositis-with-positive-anti-tif1-gamma-antibodies-in-an-adult-female-a-case-report
#33
Krishna Adhikari, Prashant Pant, Sanjeev Bhandari, Sandip Paudel, Buddhi Poudyal, Lucky Sharma, Keshav Raj Sigdel, Rojina Subedi
Dermatomyositis is an uncommon autoimmune disease with only few cases reported from Nepal. Presence of anti TIF-1 gamma antibodies in DM are the strongest predictor of malignancy. Timely screening of malignancies for early detection and management remains the mainstay of this report.
November 2023: Clinical Case Reports
https://read.qxmd.com/read/38023222/paraneoplastic-dermatomyositis-associated-with-urothelial-cancer-report-of-a-case-and-systematic-review-of-the-literature
#34
REVIEW
Josep Sabaté-Ortega, Elisabet Bujons-Buscarons, Clàudia Fina-Planas, Núria Vilanova-Anducas, Noemí Vidal-Sarró, Núria Sala-González
BACKGROUND: The idiopathic inflammatory myopathies (IIM) are a collection of autoimmune diseases that have a substantial impact on the entire body and include conditions such as dermatomyositis (DM), polymyositis (PM), sporadic inclusion body myositis, and immune-mediated necrotizing myopathy. These disorders are characterized by symptoms such as muscular weakness, pain, and dermal rash. This systematic review is intended to explore the potential link between bladder cancer and DM/PM...
2023: Frontiers in Oncology
https://read.qxmd.com/read/37991543/tanshinone-iia-is-superior-to-paricalcitol-in-ameliorating-tubulointerstitial-fibrosis-through-regulation-of-vdr-wnt-%C3%AE-catenin-pathway-in-rats-with-diabetic-nephropathy
#35
JOURNAL ARTICLE
Jing-Yi Zeng, Yu Wang, Fu-Yuan Hong, Miao Miao, Yu-Ying Jiang, Zi-Xuan Qiao, Yun-Tao Wang, Xiao-Rong Bao
Glomerulosclerosis and tubulointerstitial fibrosis (TIF) are closely involved in the development of diabetic nephropathy (DN). Moreover, the development of TIF is closely related to epithelial-to-mesenchymal transition (EMT). Tanshinone IIA (Tan) has various pharmacological effects, especially the anti-fibrotic effect. And it is mainly used in the clinical treatment of cardiovascular diseases. Currently, the protective effect of Tan on DN and its possible mechanism have not been clearly elucidated. Our previous studies illustrated that Tan could improve the EMT of HK-2 cells induced by high glucose by regulating the vitamin D receptor (VDR)/Wnt/β-catenin pathway...
November 22, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/37965620/spatial-dataset-on-future-forest-cover-changes-in-southeast-asia-projected-under-the-shared-socioeconomic-pathways
#36
JOURNAL ARTICLE
Ronald C Estoque
The five shared socioeconomic pathways (SSPs) provide future projections for various social-ecological variables, including forest cover. However, these projections are limited to quantities and lack a spatial dimension. This dataset is the result of an effort to spatialize the projected forest cover changes (losses and gains) (2015-2050) in Southeast Asia under the five baseline SSPs. The dataset is available in GIS raster format (.tif) at a spatial resolution of 300 m. A wide range of users can benefit from this dataset, as it can be used independently or in conjunction with other datasets...
December 2023: Data in Brief
https://read.qxmd.com/read/37953778/elucidating-the-role-of-nicotinamide-n-methyltransferase-p53-axis-in-the-progression-of-chronic-kidney-disease
#37
JOURNAL ARTICLE
Xin Zhen, Yuxiang Sun, Hongchun Lin, Yuebo Huang, Tianwei Liu, Yuanqing Li, Hui Peng
BACKGROUND: Chronic kidney disease (CKD) is a significant global health issue characterized by progressive loss of kidney function. Renal interstitial fibrosis (TIF) is a common feature of CKD, but current treatments are seldom effective in reversing TIF. Nicotinamide N-methyltransferase (NNMT) has been found to increase in kidneys with TIF, but its role in renal fibrosis is unclear. METHODS: Using mice with unilateral ureteral obstruction (UUO) and cultured renal interstitial fibroblast cells (NRK-49F) stimulated with transforming growth factor-β1 (TGF-β1), we investigated the function of NNMT in vivo and in vitro ...
2023: PeerJ
https://read.qxmd.com/read/37947973/laparoscopically-limited-anatomic-liver-resections-a-single-center-analysis-for-oncologic-outcomes-of-the-conceptual-procedure
#38
JOURNAL ARTICLE
Taiga Wakabayashi, Yoshiki Fujiyama, Kohei Mishima, Kazuharu Igarashi, Yusuke Nie, Giammauro Berardi, Malek Alomari, Marco Colella, Go Wakabayashi
BACKGROUND: Limited anatomic resections (LARs), such as segmentectomies, performed using a fully laparoscopic approach, have gained popularity for liver malignancies. However, the oncologic efficacy of laparoscopic LARs (Lap-LARs) needs further investigation. This cohort study evaluated the oncologic outcomes of Lap-LAR for hepatocellular carcinoma (HCC) and colorectal liver metastasis (CRLM). METHODS: At a Japanese referral center, 112 patients underwent Lap-LAR using the Glissonean approach and indocyanine green (ICG) fluorescence navigation...
November 10, 2023: Annals of Surgical Oncology
https://read.qxmd.com/read/37943391/tubular-tmem16a-promotes-tubulointerstitial-fibrosis-by-suppressing-pgc-1%C3%AE-mediated-mitochondrial-homeostasis-in-diabetic-kidney-disease
#39
JOURNAL ARTICLE
Jia-Ling Ji, Jun-Ying Li, Jian-Xiang Liang, Yan Zhou, Cong-Cong Liu, Yao Zhang, Ai-Qing Zhang, Hong Liu, Rui-Xia Ma, Zuo-Lin Li
Tubulointerstitial fibrosis (TIF) plays a crucial role in the progression of diabetic kidney disease (DKD). However, the underlying molecular mechanisms remain obscure. The present study aimed to examine whether transmembrane member 16A (TMEM16A), a Ca2+ -activated chloride channel, contributes to the development of TIF in DKD. Interestingly, we found that TMEM16A expression was significantly up-regulated in tubule of murine model of DKD, which was associated with development of TIF. In vivo inhibition of TMEM16A channel activity with specific inhibitors Ani9 effectively protects against TIF...
November 6, 2023: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/37931304/pathways-to-mental-well-being-for-graduates-of-mindfulness-based-cognitive-therapy-mbct-and-mindfulness-based-stress-reduction-mbsr-a-mediation-analysis-of-an-rct
#40
JOURNAL ARTICLE
Shannon Maloney, Jesus Montero-Marin, Willem Kuyken
OBJECTIVE: To explore mediated effects of Mindfulness-Based Cognitive Therapy-"Taking it Further" (MBCT-TiF) on mental well-being through changes in mindfulness, self-compassion, and decentering. METHOD: A secondary analysis of an RCT using simple mediation, with 164 graduates of MBCT and mindfulness-based stress reduction (MBSR), was implemented whereby MBCT-TiF (vs ongoing mindfulness practice; OMP) was the independent variable; changes in mindfulness, self-compassion, and decentering during the intervention were the mediators; and mental well-being at post-intervention, whilst controlling for baseline, was the dependent variable...
November 6, 2023: Psychotherapy Research: Journal of the Society for Psychotherapy Research
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