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https://www.readbyqxmd.com/read/28462043/lack-of-riluzole-efficacy-in-the-progression-of-the-neurodegenerative-phenotype-in-a-new-conditional-mouse-model-of-striatal-degeneration
#1
Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Piotr Chmielarz, Monika Bagińska, Irena Nalepa
BACKGROUND: Huntington's disease (HD) is a rare familial autosomal dominant neurodegenerative disorder characterized by progressive degeneration of medium spiny neurons (MSNs) located in the striatum. Currently available treatments of HD are only limited to alleviating symptoms; therefore, high expectations for an effective therapy are associated with potential replacement of lost neurons through stimulation of postnatal neurogenesis. One of the drugs of potential interest for the treatment of HD is riluzole, which may act as a positive modulator of adult neurogenesis, promoting replacement of damaged MSNs...
2017: PeerJ
https://www.readbyqxmd.com/read/28460289/effect-of-environmental-conditions-on-the-permeability-of-low-density-polyethylene-film-and-totally-impermeable-film-to-methyl-isothiocyanate-fumigant
#2
REVIEW
Wensheng Fang, Aocheng Cao, Dongdong Yan, Dawei Han, Jun Li, Xiaoman Liu, Yuan Li, Chanbin Ouyang, Qiuxia Wang
Fumigant methyl isothiocyanate (MITC) is a very promising alternative to methyl bromide, providing effective control of soil borne disease. However, there is a significant volatilization of MITC following fumigation because of its high application rates and high vapor pressure. Covering the soil surface with plastic tarps is a common approach used for restricting fumigant emissions to the atmosphere. To minimize atmospheric emissions of MITC by tarping, we determined the effect of temperature, humidity, and fumigant mixtures on the permeability to MITC of low density polyethylene film (LDPE) and totally impermeable film (TIF), using static sealed chambers...
April 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28424731/identification-of-tify-family-genes-and-analysis-of-their-expression-profiles-in-response-to-phytohormone-treatments-and-melampsora-larici-populina-infection-in-poplar
#3
Wenxiu Xia, Hongyan Yu, Pei Cao, Jie Luo, Nian Wang
The TIFY domain contains approximately 36 conserved amino acids that form the core motif TIF[F/Y]XG, and they were reported to play important roles in plant growth, tissue development and defense regulation. Moreover, more and more evidence has shown that some members of the TIFY gene family perform their functions by modulating plant hormone signaling pathways. Poplar trees are found worldwide, and they comprise approximately 30 species. Benefit from the importance of poplar and its advanced platform, this tree is considered to be the model perennial plant...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28392772/the-tromso-infant-faces-database-tif-development-validation-and-application-to-assess-parenting-experience-on-clarity-and-intensity-ratings
#4
Jana K Maack, Agnes Bohne, Dag Nordahl, Lina Livsdatter, Åsne A W Lindahl, Morten Øvervoll, Catharina E A Wang, Gerit Pfuhl
Newborns and infants are highly depending on successfully communicating their needs; e.g., through crying and facial expressions. Although there is a growing interest in the mechanisms of and possible influences on the recognition of facial expressions in infants, heretofore there exists no validated database of emotional infant faces. In the present article we introduce a standardized and freely available face database containing Caucasian infant face images from 18 infants 4 to 12 months old. The development and validation of the Tromsø Infant Faces (TIF) database is presented in Study 1...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28370527/continuous-one-step-synthesis-of-porous-m-xf6-based-metal-organic-and-hydrogen-bonded-frameworks
#5
Vincent Guillerm, Luis Garzon-Tóvar, Amirali Yazdi, Inhar Imaz, Jordi Juanhuix, Daniel Maspoch
Metal-organic frameworks (MOFs) built up from connecting M-XF6 pillars through N-donor ligands are among the most attractive adsorbents and separating agents for CO₂ and hydrocarbons today. Here, we show the continuous, one-step spray-drying synthesis of several members of this isoreticular MOF family varying the anionic pillar (X = [SiF₆]²- and [TiF₆]²-), the N-donor organic ligand (pyrazine and 4,4'-bipyridine) and the metal ion (M = Co, Cu and Zn). This synthetic method allows obtaining them in the form of spherical superstructures assembled from nanosized crystals...
March 30, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28360124/genetic-mutations-linked-to-parkinson-s-disease-differentially-control-nucleolar-activity-in-pre-symptomatic-mouse-models
#6
Valentin Evsyukov, Andrii Domanskyi, Holger Bierhoff, Suzana Gispert, Rasem Mustafa, Falk Schlaudraff, Birgit Liss, Rosanna Parlato
Genetic mutations underlying neurodegenerative disorders impair ribosomal DNA (rDNA) transcription suggesting that nucleolar dysfunction could be a novel pathomechanism in polyglutamine diseases and in certain forms of amyotrophic lateral sclerosis/frontotemporal dementia. Here, we investigated nucleolar activity in pre-symptomatic digenic models of Parkinson's disease (PD) that model the multifactorial aetiology of this disease. To this end, we analysed a novel mouse model mildly overexpressing mutant human α-synuclein (hA53T-SNCA) in a PTEN-induced kinase 1 (PINK1/PARK6) knockout background and mutant mice lacking both DJ-1 (also known as PARK7) and PINK1...
May 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28334682/phytochemical-induced-nucleolar-stress-results-in-the-inhibition-of-breast-cancer-cell-proliferation
#7
Anna Lewinska, Diana Bednarz, Jagoda Adamczyk-Grochala, Maciej Wnuk
The nucleolus is a stress sensor and compromised nucleolar activity may be considered as an attractive anticancer strategy. In the present study, the effects of three plant-derived natural compounds, i.e., sulforaphane (SFN), ursolic acid (UA) and betulinic acid (BA) on nucleolar state were investigated in breast cancer cell lines of different receptor status, namely MCF-7, MDA-MB-231 and SK-BR-3 cells. Cytostatic action of phytochemicals against breast cancer cells was observed at low micromolar concentration window (5-20µM) and mediated by elevated p21 levels, and cell proliferation of SFN-, UA- and BA-treated normal human mammary epithelial cells (HMEC) was unaffected...
March 14, 2017: Redox Biology
https://www.readbyqxmd.com/read/28324505/probing-the-telomere-damage-response
#8
Rekha Rai, Sandy Chang
Telomere dysfunctions, rendered through replicative attrition of telomeric DNA or due to the removal of shelterin components, are recognized as DNA double-stranded breaks (DSBs) by the DNA damage repair (DDR) pathway. This leads to the activation of DNA damage checkpoint sensors, including the Mre11-Rad50-Nbs1 (MRN) complex, γ-H2AX and 53BP1, the ATM and ATR signal-transducing kinases, and downstream effectors, including Chk1, Chk2, and p53. Robust DNA damage response signals at dysfunctional telomeres, achieved by the complete deletion of TRF2 or by expressing dominant-negative mutant TPP1ΔRD, can be detected by their association with γ-H2AX and 53BP1 forming "telomere dysfunction induced foci (TIFs)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28320873/sav1-loss-induces-senescence-and-stat3-activation-coinciding-with-tubulointerstitial-fibrosis
#9
Janet Y Leung, Harper L Wilson, Kristin J Voltzke, Lindsay A Williams, Hyo Jin Lee, Sara E Wobker, William Y Kim
Tubulointerstitial fibrosis (TIF) is recognized as a final phenotypic manifestation in the transition from chronic kidney disease (CKD) to end-stage renal disease (ESRD). Here, we show that conditional inactivation of Sav1 in the mouse renal epithelium resulted in upregulated expression of profibrotic genes and TIF. Loss of Sav1 induced Stat3 activation and a senescence-associated secretory phenotype (SASP) that coincided with the development of tubulointerstitial fibrosis. Treatment of mice with the YAP inhibitor, Verteporfin (VP), inhibited activation of genes associated with senescence, SASP and activation of Stat3 as well as impeded the development of fibrosis...
March 20, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28315683/klotho-ameliorates-cyclosporine-a-induced-nephropathy-via-pdlim2-nf-kb-p65-signaling-pathway
#10
Meihua Jin, Pengfei Lv, Guanyu Chen, Peng Wang, Zhongfu Zuo, Lili Ren, Jing Bi, Chul-Woo Yang, Xifan Mei, Donghe Han
Klotho, an antiaging protein, can extend the lifespan and modulate cellular responses to inflammation and oxidative stress which can ameliorate chronic kidney diseases (CKD). To investigate the molecular mechanism of Klotho on inflammation in cyclosporine A (CsA) induced nephropathy, the mice were transfected with adenovirus mediated Klotho gene and treated with cyclosporine A (CsA; 30 mg/kg/day) for 4 weeks. Also, primary human renal proximal tubule epithelial cells (RPTECs) were treated with soluble Klotho protein and LPS...
March 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28296655/endoscopic-fundoplication-effectiveness-for-controlling-symptoms-of-gastroesophageal-reflux-disease
#11
Michael I Ebright, Praveen Sridhar, Virginia R Litle, Chaitan K Narsule, Benedict D Daly, Hiran C Fernando
OBJECTIVE: Transoral incisionless fundoplication (TIF) is a completely endoscopic approach to treat gastroesophageal reflux disease (GERD). We previously reported our initial results demonstrating safety and early effectiveness. We now present an updated experience describing outcomes with longer follow-up. METHODS: For a three-year period, TIF procedures were performed on 80 patients. Preoperative workup routinely consisted of contrast esophagram and manometry...
March 14, 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/28271295/rheological-behaviors-of-thickened-infant-formula-prepared-with-xanthan-gum-based-food-thickeners-for-dysphagic-infants
#12
Sung-No Yoon, Byoungseung Yoo
Thickened infant formula (TIF) prepared with commercial xanthan gum (XG)-based food thickeners are commonly used to care for infants with swallowing difficulties or regurgitation. In this study, the rheological properties of TIF prepared with four commercial food thickeners (coded A-D) were determined as a function of thickener concentration, thickener type, and setting time because the selection of an appropriate food thickener for TIF preparation is necessary for managing dysphagia in infants. The flow and dynamic rheological properties of TIF were investigated at three different concentrations (1...
June 2017: Dysphagia
https://www.readbyqxmd.com/read/28250236/tgfb1-represses-the-expression-of-sf1-and-lrh1-to-inhibit-e2-production-in-rat-lcs
#13
Qianqian Yang, Binfang Ma, Huilian Qiao, He Ma, Yuhang Dong, Liang Cao, Jing Ma, Zhen Li
Leydig cells (LCs) in the adult testis have been identified as the major sites of oestrogen production, which is crucial for mammalian germ cell differentiation. Our previous work showed that transforming growth factor beta 1 (TGFB1) inhibits estradiol (E2) secretion via down-regulating Cyp19 gene expression in mature rat (LCs). However, the mechanism remains unclear. In the present study, the effects of TGFB1 on the expression levels of steroidogenic factor 1 (SF1), liver receptor homolog 1 (LRH1), cAMP response element-binding protein (CREB) and cAMP responsive element modulator (CREM) were evaluated by Western blotting and immunofluorescence staining both in primary cultured LCs and in rat testis...
March 1, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28241382/passerine-morphology-external-measurements-of-approximately-one-quarter-of-passerine-bird-species
#14
Robert E Ricklefs
Studies of community organization and clade diversification that include functional traits have become an important component of the analysis of ecological and evolved systems. Such studies frequently are limited by availability of consistently collected data. Here, I present a data set including eight measurements of the external morphology of 1642 species, roughly one-quarter of all passerine birds (Aves: Order Passeriformes), from all parts of the world, characterizing the relative proportions of the wing, tail, legs, and beak...
February 27, 2017: Ecology
https://www.readbyqxmd.com/read/28197382/s100a8-stroma-cells-predict-a-good-prognosis-and-inhibit-aggressiveness-in-colorectal-carcinoma
#15
Si Li, Fangying Xu, Hui Li, Jing Zhang, Anjing Zhong, Bin Huang, Maode Lai
Gene microarray and bioinformatic analysis showed that S100A8 was more abundant in the stroma surrounding tumor buddings (TBs) than in the stroma surrounding primary tumor cells in colorectal carcinomas. Here, S100A8(+) cells in 419 colorectal carcinoma samples were stained by immunohistochemistry and counted using Image-pro plus 6.0. TBs were also counted and biomarkers associated with the epithelial-mesenchymal transition and apoptosis were assessed by immunohistochemistry. We evaluated the association between S100A8(+) cells and clinico-pathological variables as well as survival...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28192182/male-reproductive-toxicity-of-crvi-in-utero-exposure-to-crvi-at-the-critical-window-of-testis-differentiation-represses-the-expression-of-sertoli-cell-tight-junction-proteins-and-hormone-receptors-in-adult-f1-progeny-rats
#16
Kathiresh M Kumar, Mariajoseph Michael Aruldhas, Sheerin L Banu, Balaji Sadasivam, Ganapathy Vengatesh, Karthik M Ganesh, Shobana Navaneethabalakrishnan, Ajith Kumar Navin, Felicia Mary Michael, Sankar Venkatachalam, Jone A Stanley, Ilangovan Ramachandran, Sakhila K Banu, Mohammad Abdulkader Akbarsha
The effect of gestational exposure to CrVI (occupational/environmental pollutant and target to Sertoli cells(SC)) was tested in a rat model during the testicular differentiation from the bipotential gonad may interrupt spermatogenesis by disrupting SC tight junctions(TJ) and it's proteins and hormone receptors. Pregnant Wistar rats were exposed to 50/100/200ppm CrVI through drinking water during embryonic days 9-14. On Postnatal day 120, testes were subjected to ion exchange chromatographic analysis and revealed increased level of CrIII in SCs and germ cells, serum and testicular interstitial fluid(TIF)...
February 10, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28145100/profiling-of-micrornas-in-tumor-interstitial-fluid-of-breast-tumors-a-novel-resource-to-identify-biomarkers-for-prognostic-classification-and-detection-of-cancer
#17
Ann Rita Halvorsen, Åslaug Helland, Pavel Gromov, Vera Timmermans Wielenga, Maj-Lis Møller Talman, Nils Brunner, Vandana Sandhu, Anne-Lise Børresen-Dale, Irina Gromova, Vilde D Haakensen
It has been hypothesized based on accumulated data that a class of small noncoding RNAs, termed microRNAs, are key factors in intercellular communication. Here, microRNAs present in interstitial breast tumor fluids have been analyzed to identify relevant markers for a diagnosis of breast cancer and to elucidate the cross-talk that exists among cells in a tumor microenvironment. Matched tumor interstitial fluid samples (TIF, n = 60), normal interstitial fluid samples (NIF, n = 51), corresponding tumor tissue specimens (n = 54), and serum samples (n = 27) were collected from patients with breast cancer, and detectable microRNAs were analyzed and compared...
February 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28100501/mdm2-mediates-fibroblast-activation-and-renal-tubulointerstitial-fibrosis-via-p53-independent-pathway
#18
Chen Ye, Hui Tang, Zheng Zhao, Chun-Tao Lei, Chao-Qun You, Jiao Zhang, Pan Gao, Fang-Fang He, Shan Chen, Yumei Wang, Chun Zhang, Hua Su
It is well-recognized that Murine Double Minute gene 2 (MDM2) plays a critical role in cell proliferation and inflammatory processes during tumorigenesis. Also it is reported that MDM2 is expressed in glomeruli and involved in podocyte injury. However, whether MDM2 is implicated in renal fibrosis remains unclear. Here we investigated the role of MDM2 in tubulointerstitial fibrosis (TIF). By immunohistochemical staining and western blotting we confirmed that MDM2 is up-regulated in tubulointerstitial compartment in TIF patients and Unilateral Urethral Obstruction (UUO) mice, which mainly originates from myofibroblasts...
January 18, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28077323/high-glucose-down-regulates-microrna-181a-5p-to-increase-pro-fibrotic-gene-expression-by-targeting-early-growth-response-factor-1-in-hk-2-cells
#19
Ping Xu, Mei-Ping Guan, Jian-Gang Bi, Dan Wang, Zong-Ji Zheng, Yao-Ming Xue
Tubulointerstitial fibrosis (TIF) plays an important role in the progression of renal fibrosis in diabetic nephropathy (DN). Accumulating evidence supports a crucial effect of early growth response factor 1 (Egr1) on renal fibrosis in DN, but the underlying mechanisms are not entirely clear. Here, we explored the aggravating role of Egr1 and identified microRNA-181a-5p (miR-181a-5p) as an upstream regulator of Egr1 in TIF of DN. We demonstrated that overexpression of Egr1 enhanced, whereas small interfering RNA targeting Egr1 decreased the expressions of transforming growth factor β1 (TGF-β1) and fibrosis-related genes including fibronectin and collagen I in human proximal tubule cell line (HK-2) cells...
February 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28059243/modeling-of-edge-effect-in-subaperture-tool-influence-functions-of-computer-controlled-optical-surfacing
#20
Songlin Wan, Xiangchao Zhang, Xiaoying He, Min Xu
Computer controlled optical surfacing requires an accurate tool influence function (TIF) for reliable path planning and deterministic fabrication. Near the edge of the workpieces, the TIF has a nonlinear removal behavior, which will cause a severe edge-roll phenomenon. In the present paper, a new edge pressure model is developed based on the finite element analysis results. The model is represented as the product of a basic pressure function and a correcting function. The basic pressure distribution is calculated according to the surface shape of the polishing pad, and the correcting function is used to compensate the errors caused by the edge effect...
December 20, 2016: Applied Optics
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