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https://www.readbyqxmd.com/read/29139078/combination-strategy-of-quantitative-proteomics-uncovers-the-related-proteins-of-colorectal-cancer-in-the-interstitial-fluid-of-colonic-tissue-from-the-aom-dss-mouse-model
#1
Guixue Hou, Yang Wang, Xiaomin Lou, Siqi Liu
Quantitative proteome analysis using iTRAQ is an important technique to find disease-related proteins. As an important component of tumor microenvironment, tissue interstitial fluid (TIF) has drawn a great attention for its potential as a source for exploration of the solid tumor biomarkers. On the basis of a mouse model of colorectal cancer (CRC) that was induced by the carcinogenetic reagents, we adopted a quantitative proteome analysis with iTRAQ to discover the CRC-related proteins in the TIFs and with MRM to evaluate the corresponding abundance changes in the individual mouse TIF and serum samples...
November 15, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29134494/expression-of-telomere-associated-proteins-is-interdependent-to-stabilize-native-telomere-structure-and-telomere-dysfunction-by-g-quadruplex-ligand-causes-terra-upregulation
#2
Ratan Sadhukhan, Priyanka Chowdhury, Sourav Ghosh, Utpal Ghosh
Telomere DNA can form specialized nucleoprotein structure with telomere-associated proteins to hide free DNA ends or G-quadruplex structures under certain conditions especially in presence of G-quadruplex ligand. Telomere DNA is transcribed to form non-coding telomere repeat-containing RNA (TERRA) whose biogenesis and function is poorly understood. Our aim was to find the role of telomere-associated proteins and telomere structures in TERRA transcription. We silenced four [two shelterin (TRF1, TRF2) and two non-shelterin (PARP-1, SLX4)] telomere-associated genes using siRNA and verified depletion in protein level...
November 13, 2017: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29116298/in-situ-effect-of-titanium-tetrafluoride-varnish-on-enamel-demineralization
#3
Adílis Kalina Alexandria, Camila Nassur, Carolina Bezerra Cavalcanti Nóbrega, Ana Maria Gondim Valença, Pedro Luiz Rosalen, Lucianne Cople Maia
The effect of a 4% titanium tetrafluoride (TiF 4 ) varnish on enamel demineralization was evaluated. Twelve volunteers participated in this double-blind, randomized crossover study. Six enamel specimens were positioned in intraoral appliances throughout four treatment stages: 4% TiF 4 varnish (experimental varnish), 5% sodium fluoride (NaF) varnish (Duraphat ® ), placebo varnish, and negative control (deionized water). After 24 h, the varnishes were removed and plaques were allowed to accumulate. A 20% sucrose solution was dripped onto enamel blocks (10x/day)...
November 6, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/29078681/endoscopic-fundoplication-patient-selection-and-technique
#4
REVIEW
Hiran C Fernando
Gastroesophageal reflux disease (GERD) is a common condition that places a significant burden on the healthcare system. Additionally, there have been concerns raised about potential risks of long-term proton pump inhibitors. Laparoscopic anti-reflux surgery is currently the gold standard option for patients when surgery is planned. However, there continues to be interest in an endoscopic, alternative to laparoscopic surgery. Transoral incisionless fundoplication (TIF) is being increasingly utilized for such patients...
2017: J Vis Surg
https://www.readbyqxmd.com/read/29049004/long-term-outcomes-of-transoral-incisionless-fundoplication-in-a-high-risk-pediatric-population
#5
Jason O Robertson, Marcus D Jarboe
INTRODUCTION: Laparoscopic Nissen fundoplication (LNF) is the standard for surgical treatment of gastroesophageal reflux disease (GERD), but postoperative complications and pain are common in patients with severe neurological impairment (NI) and those undergoing reoperative procedures. Transoral incisionless fundoplication (TIF) is an endoscopic alternative to treat GERD. Long-term results in pediatric populations are unknown. METHODS: Eleven patients who underwent TIF between January 2008 and September 2010 were included...
October 19, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29047857/optimization-technique-for-rolled-edge-control-process-based-on-the-acentric-tool-influence-functions
#6
Hang Du, Ci Song, Shengyi Li, Mingjin Xu, Xiaoqiang Peng
In the process of computer controlled optical surfacing (CCOS), the uncontrollable rolled edge restricts further improvements of the machining accuracy and efficiency. Two reasons are responsible for the rolled edge problem during small tool polishing. One is that the edge areas cannot be processed because of the orbit movement. The other is that changing the tool influence function (TIF) is difficult to compensate for in algorithms, since pressure step appears in the local pressure distribution at the surface edge...
May 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/29024941/in-depth-proteomic-analysis-of-tissue-interstitial-fluid-for-hepatocellular-carcinoma-serum-biomarker-discovery
#7
Jian Zhang, Ning Hao, Wei Liu, Min Lu, Longqin Sun, Ning Chen, Miantao Wu, Xiaohang Zhao, Baocai Xing, Wei Sun, Fuchu He
BACKGROUND: Hepatocellular carcinoma (HCC) is a primary malignancy of the liver. New serum biomarkers for HCC screening are needed, especially for alpha-fetoprotein (AFP) negative patients. As a proximal fluid between body fluids and intracellular fluid, tissue interstitial fluid (TIF) is a suitable source for serum biomarker discovery. METHODS: Sixteen paired TIF samples from HCC tumour and adjacent non-tumour tissues were analysed by isobaric tags for relative and absolute quantitation (iTRAQ) method...
October 12, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29021386/suppression-of-microrna-activity-in-kidney-collecting-ducts-induces-partial-loss-of-epithelial-phenotype-and-renal-fibrosis
#8
Sachin Hajarnis, Matanel Yheskel, Darren Williams, Thomas Brefort, Bob Glaudemans, Huguette Debaix, Michel Baum, Olivier Devuyst, Vishal Patel
microRNAs (miRNAs) are sequence-specific inhibitors of post-transcriptional gene expression. The physiologic function of these noncoding RNAs in postnatal renal tubules still remains unclear. Surprisingly, they appear to be dispensable for mammalian proximal tubule (PT) function. Here, we examined the effects of miRNA suppression in collecting ducts (CDs). To conclusively evaluate the role of miRNAs, we generated three mouse models with CD-specific inactivation of key miRNA pathway genes Dicer, Dgcr8, and the entire Argonaute gene family (Ago1, 2, 3, and 4)...
October 11, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28981335/strengthening-the-hiv-care-continuum-in-the-dominican-republic-application-of-a-triadic-implementation-framework-to-meet-the-unaids-90-90-90-treatment-goal
#9
Alex S Bowman, Mili Mehta, Leonel Lerebours Nadal, Mina Halpern, Stephen W Nicholas, Silvia Amesty
Innovative empirical frameworks to evaluate progress in efforts addressing HIV treatment and prevention barriers in resource-limited areas are sorely needed to achieve the UNAIDS 90-90-90 goal (90% diagnosed, 90% on treatment, and 90% virally suppressed). A triadic implementation framework (TIF) is a comprehensive conceptual tool for (1) monitoring attrition, (2) evaluating operational programs, and (3) measuring the impact of specific implementation goals within the care continuum. TIF will assess the effects of enhanced programs on adherence and virologic suppression within the HIV care continuum at a regional clinic in the Dominican Republic (Clínica de Familia La Romana [CFLR]) and its program serving high-risk, migratory batey (sugarcane cultivation) communities...
October 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28919993/tumor-necrosis-and-infiltrating-macrophages-predict-survival-after-curative-resection-for-cholangiocarcinoma
#10
Georgi Atanasov, Corinna Dietel, Linda Feldbrügge, Christian Benzing, Felix Krenzien, Andreas Brandl, Elli Mann, Julianna Paulina Englisch, Katrin Schierle, Simon C Robson, Katrin Splith, Mehmet Haluk Morgul, Anja Reutzel-Selke, Sven Jonas, Andreas Pascher, Marcus Bahra, Johann Pratschke, Moritz Schmelzle
Background. Tumor necrosis as well as tumor-associated macrophages (TAMs) in the tumor invasive front (TIF) have been suggested to have a prognostic value in selected solid tumors, inclusive hilar cholangiocarcinoma. However, little is known regarding their influence on tumor progression and prognosis in intrahepatic cholangiocarcinoma (iCC). Methods. We analyzed surgically resected tumor specimens of human iCC (n = 88) for distribution and localization of TAMs, as defined by expression of CD68, formation of necrosis and extent of peritumoral fibrosis...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28835357/activation-of-%C3%AE-2-ampk-suppresses-ribosome-biogenesis-and-protects-against-myocardial-ischemia-reperfusion-injury
#11
Yang Cao, Naveen Bojjireddy, Maengjo Kim, Tao Li, Peiyong Zhai, Narayani Nagarajan, Junichi Sadoshima, Richard D Palmiter, Rong Tian
RATIONALE: AMPK (AMP-activated protein kinase) is a heterotrimeric protein that plays an important role in energy homeostasis and cardioprotection. Two isoforms of each subunit are expressed in the heart, but the isoform-specific function of AMPK remains unclear. OBJECTIVE: We sought to determine the role of γ2-AMPK in cardiac stress response using bioengineered cell lines and mouse models containing either isoform of the γ-subunit in the heart. METHODS AND RESULTS: We found that γ2 but not γ1 or γ3 subunit translocated into nucleus on AMPK activation...
October 27, 2017: Circulation Research
https://www.readbyqxmd.com/read/28773987/grain-refinement-efficiency-in-commercial-purity-aluminum-influenced-by-the-addition-of-al-4ti-master-alloys-with-varying-tial%C3%A2-particles
#12
Jianhua Zhao, Jiansheng He, Qi Tang, Tao Wang, Jing Chen
A series of Al-4Ti master alloys with various TiAl₃ particles were prepared via pouring the pure aluminum added with K₂TiF₆ or sponge titanium into three different molds made of graphite, copper, and sand. The microstructure and morphology of TiAl₃ particles were characterized and analyzed by scanning electron microscope (SEM) with energy dispersive spectroscopy (EDS). The microstructure of TiAl₃ particles in Al-4Ti master alloys and their grain refinement efficiency in commercial-purity aluminum were investigated in this study...
October 26, 2016: Materials
https://www.readbyqxmd.com/read/28750410/loss-of-the-protein-cystathionine-%C3%AE-synthase-during-kidney-injury-promotes-renal-tubulointerstitial-fibrosis
#13
Xiangning Yuan, Jin Zhang, Feifei Xie, Wenqing Tan, Shuting Wang, Ling Huang, Lijian Tao, Qiqi Xing, Qiongjing Yuan
BACKGROUND/AIMS: Renal tubulointerstitial fibrosis (TIF) is the common pathway of progressive chronic kidney disease. Inflammation has been widely accepted as the major driving force of TIF. Cystathionine β-synthase (CBS) is the first and rate-limiting enzyme in the transsulfuration pathway. CBS is considered to play protective role in liver and pulmonary fibrosis, but its role in TIF remains unknown. The purpose of this study was to investigate the potential role and mechanism of CBS in renal inflammation and TIF...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28731227/dithiopheneindenofluorene-tif-semiconducting-polymers-with-very-high-mobility-in-field-effect-transistors
#14
Hu Chen, Michael Hurhangee, Mark Nikolka, Weimin Zhang, Mindaugas Kirkus, Marios Neophytou, Samuel J Cryer, David Harkin, Pascal Hayoz, Mojtaba Abdi-Jalebi, Christopher R McNeill, Henning Sirringhaus, Iain McCulloch
The charge-carrier mobility of organic semiconducting polymers is known to be enhanced when the energetic disorder of the polymer is minimized. Fused, planar aromatic ring structures contribute to reducing the polymer conformational disorder, as demonstrated by polymers containing the indacenodithiophene (IDT) repeat unit, which have both a low Urbach energy and a high mobility in thin-film-transistor (TFT) devices. Expanding on this design motif, copolymers containing the dithiopheneindenofluorene repeat unit are synthesized, which extends the fused aromatic structure with two additional phenyl rings, further rigidifying the polymer backbone...
July 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28724608/erbb4-deletion-accelerates-renal-fibrosis-following-renal-injury
#15
Fenghua Zeng, Tomoki Miyazawa, Lance A Kloepfer, Raymond C Harris
Tubulointerstitial fibrosis (TIF) is a prominent factor in the progression of chronic kidney disease (CKD) regardless of etiology. ErbB4 expression levels were inversely correlated to renal fibrosis in human fibrotic kidneys. In both unilateral ureteral obstruction (UUO) and ischemia reperfusion injury followed by uninephrectomy (IRI/UNx) mouse models, expression levels of ErbB4 were elevated in the early stage of renal injury. Using mice with global ErbB4 deletion except for transgenic rescue in cardiac tissue (ErbB4-/-ht+), we determined that UUO induced similar injury in proximal tubules compared to wild-type mice but more severe injury in distal nephrons...
July 19, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28723474/introducing-the-twitter-impact-factor-an-objective-measure-of-urology-s-academic-impact-on-twitter
#16
Diana Cardona-Grau, Igor Sorokin, Gabriel Leinwand, Charles Welliver
BACKGROUND: Social media use in academia and urology is rising. Specifically, individual journals now have Twitter accounts (Twitter Inc, San Francisco, CA, USA) and regularly tweet academic content. OBJECTIVE: To present and evaluate the Twitter impact factor (TIF), a novel means of measuring a journal's academic influence in the realm of social media. DESIGN, SETTING, AND PARTICIPANTS: Journal Citation Reports (JCR; Thomson Reuters, New York, NY, USA) for 2014 was queried for urologic academic journals...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28710113/trap1-ameliorates-renal-tubulointerstitial-fibrosis-in-mice-with-unilateral-ureteral-obstruction-by-protecting-renal-tubular-epithelial-cell-mitochondria
#17
Jun-Feng Chen, Qi-Shun Wu, Yu-Xian Xie, Bo-Lin Si, Ping-Ping Yang, Wen-Yan Wang, Qin Hua, Qing He
Mitochondrial dysfunction causes renal tubular epithelial cell injury and promotes cell apoptosis and renal tubulointerstitial fibrosis (TIF) progression. TNF receptor-associated protein 1 (TRAP1) is a molecular chaperone protein that is localized in mitochondria. It plays an important role in cell apoptosis; however, its functional mechanism in TIF remains unclear. In this study, we observed the effects of TRAP1 in renal tubular epithelial cell mitochondria in mice with unilateral ureteral obstruction and its function in cell apoptosis and TIF...
October 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28678951/cell-proliferation-markers-at-the-invasive-tumor-front-of-oral-squamous-cell-carcinoma-comparative-analysis-in-relation-to-clinicopathological-parameters-of-patients
#18
Aurita Veronica Beovide Cortegoso, Natalia Koerich Laureano, Alessandra Dutra da Silva, Chris Krebs Danilevicz, Alessandra Sellinger Magnusson, Fernanda Visioli, Pantelis Varvaki Rados
Objectives: To evaluate the number of AgNORs per nucleus and the expression of Ki-67 at the tumor invasion front (TIF) in relation to clinical parameters (TNM), TIF classification and the prognosis of oral squamous cell carcinomas in an Uruguayan population. Material and Methods: This study was conducted through a retrospective survey from 2000 to 2010 at the National Institute of Cancer Montevideo, Uruguay and included 40 patients. The samples were obtained from the resection of the tumor and the TIF was defined according with Bryne, et al...
May 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28676338/dyrk2-involved-in-regulating-lps-induced-neuronal-apoptosis
#19
Yuxiang Sun, Xin Ge, Mengmeng Li, Li Xu, Yaodong Shen
The activation of relevant signaling pathways plays a very important role in LPS-induced neuronal damage. Dual-specificity tyrosine-phosphorylation-regulated kinase 2(Dyrk2), as a phosphokinase that can directly or indirectly phosphorylate signal molecules, was recently reported to down-regulate Type I Interferon(TIF) by promoting ser527 phosphorylation of TBK1. To further investigate the role of Dyrk2 in neuroinflammation, we for the first time focused on its function in LPS-induced neuronal damage. We found LPS stimulation increased the expression of Dyrk2 in the nucleus and cytoplasm of neurons...
November 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28639716/expression-of-the-autoantigen-trim33-tif1%C3%AE-in-skin-and-muscle-of-patients-with-dermatomyositis-is-upregulated-together-with-markers-of-cellular-stress
#20
B Scholtissek, S Ferring-Schmitt, J Maier, J Wenzel
Dermatomyositis (DM) is an autoimmune disorder associated with a dysregulation of immune homeostasis of both the innate and adaptive immune system. Earlier data suggested that these two arms of the immune system interconnect in DM. In the current study, we analysed the association of autoantigen expression [adaptive system components: Mi2, transcriptional intermediary factor (TIF)1γ, small ubiquitin-like modifier 1 activating enzyme subunit (SAE)1, melanoma differentiation-associated protein (MDA)5] with markers of cellular stress (innate system components: MxA, p53) in skin and muscle (immunohistology and gene expression data, respectively)...
August 2017: Clinical and Experimental Dermatology
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