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https://www.readbyqxmd.com/read/28773987/grain-refinement-efficiency-in-commercial-purity-aluminum-influenced-by-the-addition-of-al-4ti-master-alloys-with-varying-tial%C3%A2-particles
#1
Jianhua Zhao, Jiansheng He, Qi Tang, Tao Wang, Jing Chen
A series of Al-4Ti master alloys with various TiAl₃ particles were prepared via pouring the pure aluminum added with K₂TiF₆ or sponge titanium into three different molds made of graphite, copper, and sand. The microstructure and morphology of TiAl₃ particles were characterized and analyzed by scanning electron microscope (SEM) with energy dispersive spectroscopy (EDS). The microstructure of TiAl₃ particles in Al-4Ti master alloys and their grain refinement efficiency in commercial-purity aluminum were investigated in this study...
October 26, 2016: Materials
https://www.readbyqxmd.com/read/28750410/loss-of-the-protein-cystathionine-%C3%AE-synthase-during-kidney-injury-promotes-renal-tubulointerstitial-fibrosis
#2
Xiangning Yuan, Jin Zhang, Feifei Xie, Wenqing Tan, Shuting Wang, Ling Huang, Lijian Tao, Qiqi Xing, Qiongjing Yuan
BACKGROUND/AIMS: Renal tubulointerstitial fibrosis (TIF) is the common pathway of progressive chronic kidney disease. Inflammation has been widely accepted as the major driving force of TIF. Cystathionine β-synthase (CBS) is the first and rate-limiting enzyme in the transsulfuration pathway. CBS is considered to play protective role in liver and pulmonary fibrosis, but its role in TIF remains unknown. The purpose of this study was to investigate the potential role and mechanism of CBS in renal inflammation and TIF...
July 27, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28731227/dithiopheneindenofluorene-tif-semiconducting-polymers-with-very-high-mobility-in-field-effect-transistors
#3
Hu Chen, Michael Hurhangee, Mark Nikolka, Weimin Zhang, Mindaugas Kirkus, Marios Neophytou, Samuel J Cryer, David Harkin, Pascal Hayoz, Mojtaba Abdi-Jalebi, Christopher R McNeill, Henning Sirringhaus, Iain McCulloch
The charge-carrier mobility of organic semiconducting polymers is known to be enhanced when the energetic disorder of the polymer is minimized. Fused, planar aromatic ring structures contribute to reducing the polymer conformational disorder, as demonstrated by polymers containing the indacenodithiophene (IDT) repeat unit, which have both a low Urbach energy and a high mobility in thin-film-transistor (TFT) devices. Expanding on this design motif, copolymers containing the dithiopheneindenofluorene repeat unit are synthesized, which extends the fused aromatic structure with two additional phenyl rings, further rigidifying the polymer backbone...
July 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28724608/erbb4-deletion-accelerates-renal-fibrosis-following-renal-injury
#4
Fenghua Zeng, Tomoki Miyazawa, Lance A Kloepfer, Raymond C Harris
Tubulointerstitial fibrosis (TIF) is a prominent factor in the progression of chronic kidney disease (CKD) regardless of etiology. ErbB4 expression levels were inversely correlated to renal fibrosis in human fibrotic kidneys. In both unilateral ureteral obstruction (UUO) and ischemia reperfusion injury followed by uninephrectomy (IRI/UNx) mouse models, expression levels of ErbB4 were elevated in the early stage of renal injury. Using mice with global ErbB4 deletion except for transgenic rescue in cardiac tissue (ErbB4-/-ht+), we determined that UUO induced similar injury in proximal tubules compared to wild-type mice but more severe injury in distal nephrons...
July 19, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28723474/introducing-the-twitter-impact-factor-an-objective-measure-of-urology-s-academic-impact-on-twitter
#5
Diana Cardona-Grau, Igor Sorokin, Gabriel Leinwand, Charles Welliver
BACKGROUND: Social media use in academia and urology is rising. Specifically, individual journals now have Twitter accounts (Twitter Inc, San Francisco, CA, USA) and regularly tweet academic content. OBJECTIVE: To present and evaluate the Twitter impact factor (TIF), a novel means of measuring a journal's academic influence in the realm of social media. DESIGN, SETTING, AND PARTICIPANTS: Journal Citation Reports (JCR; Thomson Reuters, New York, NY, USA) for 2014 was queried for urologic academic journals...
October 2016: European Urology Focus
https://www.readbyqxmd.com/read/28710113/trap1-ameliorates-renal-tubulointerstitial-fibrosis-in-mice-with-unilateral-ureteral-obstruction-by-protecting-renal-tubular-epithelial-cell-mitochondria
#6
Jun-Feng Chen, Qi-Shun Wu, Yu-Xian Xie, Bo-Lin Si, Ping-Ping Yang, Wen-Yan Wang, Qin Hua, Qing He
Mitochondrial dysfunction causes renal tubular epithelial cell injury and promotes cell apoptosis and renal tubulointerstitial fibrosis (TIF) progression. TNF receptor-associated protein 1 (TRAP1) is a molecular chaperone protein that is localized in mitochondria. It plays an important role in cell apoptosis; however, its functional mechanism in TIF remains unclear. In this study, we observed the effects of TRAP1 in renal tubular epithelial cell mitochondria in mice with unilateral ureteral obstruction and its function in cell apoptosis and TIF...
July 14, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28678951/cell-proliferation-markers-at-the-invasive-tumor-front-of-oral-squamous-cell-carcinoma-comparative-analysis-in-relation-to-clinicopathological-parameters-of-patients
#7
Aurita Veronica Beovide Cortegoso, Natalia Koerich Laureano, Alessandra Dutra da Silva, Chris Krebs Danilevicz, Alessandra Sellinger Magnusson, Fernanda Visioli, Pantelis Varvaki Rados
Objectives: To evaluate the number of AgNORs per nucleus and the expression of Ki-67 at the tumor invasion front (TIF) in relation to clinical parameters (TNM), TIF classification and the prognosis of oral squamous cell carcinomas in an Uruguayan population. Material and Methods: This study was conducted through a retrospective survey from 2000 to 2010 at the National Institute of Cancer Montevideo, Uruguay and included 40 patients. The samples were obtained from the resection of the tumor and the TIF was defined according with Bryne, et al...
May 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28676338/dyrk2-involved-in-regulating-lps-induced-neuronal-apoptosis
#8
Yuxiang Sun, Xin Ge, Mengmeng Li, Li Xu, Yaodong Shen
The activation of relevant signaling pathways plays a very important role in LPS-induced neuronal damage. Dual-specificity tyrosine-phosphorylation-regulated kinase 2(Dyrk2), as a phosphokinase that can directly or indirectly phosphorylate signal molecules, was recently reported to down-regulate Type I Interferon(TIF) by promoting ser527 phosphorylation of TBK1. To further investigate the role of Dyrk2 in neuroinflammation, we for the first time focused on its function in LPS-induced neuronal damage. We found LPS stimulation increased the expression of Dyrk2 in the nucleus and cytoplasm of neurons...
July 1, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28639716/expression-of-the-autoantigen-trim33-tif1%C3%AE-in-skin-and-muscle-of-patients-with-dermatomyositis-is-upregulated-together-with-markers-of-cellular-stress
#9
B Scholtissek, S Ferring-Schmitt, J Maier, J Wenzel
Dermatomyositis (DM) is an autoimmune disorder associated with a dysregulation of immune homeostasis of both the innate and adaptive immune system. Earlier data suggested that these two arms of the immune system interconnect in DM. In the current study, we analysed the association of autoantigen expression [adaptive system components: Mi2, transcriptional intermediary factor (TIF)1γ, small ubiquitin-like modifier 1 activating enzyme subunit (SAE)1, melanoma differentiation-associated protein (MDA)5] with markers of cellular stress (innate system components: MxA, p53) in skin and muscle (immunohistology and gene expression data, respectively)...
August 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28609687/off-tarp-emissions-distribution-and-efficacy-of-carbonated-fumigants-in-a-low-permeability-film-tarped-field
#10
Ruijun Qin, Suduan Gao, John E Thomas, Dong Wang, Bradley D Hanson
Carbonated fumigants have been shown to distribute quickly and uniformly in sandy soils and improve pest control efficacy for annual crops. Low permeability films, such as VaporSafe® (TIF), could further improve fumigant dispersion by effectively retaining the fumigant in soil; however, there is a concern that the TIF can lead to higher off-tarp edge emissions. An orchard field trial was conducted to determine the off-tarp emissions, distribution, efficacy, and fate of carbonated Telone® C35 [63.4% 1,3-dichloropropene (1,3-D), 34...
June 10, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28545797/the-local-reliability-of-the-15-item-version-of-the-geriatric-depression-scale-an-item-response-theory-irt-study
#11
Francesca Chiesi, Caterina Primi, Martina Pigliautile, Sara Ercolani, Manuela Conestabile Della Staffa, Annalisa Longo, Virginia Boccardi, Patrizia Mecocci
The 15-item version of the Geriatric Depression Scale (GDS-15) is a self-report screening instrument widely used. The current study aimed at providing evidence of the measurement precision of the GDS-15 applying Item Response Theory (IRT). The relative contribution of each item and the reliability of the whole scale in measuring the trait level around the cutoffs were investigated employing data collected from a sample consisting of 1344 old people (M=76.44years, SD=5.13; 58.7% women) involved in a large gerontological research project...
May 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28545667/arctigenin-suppresses-renal-interstitial-fibrosis-in-a-rat-model-of-obstructive-nephropathy
#12
Ao Li, Xiaoxun Zhang, Mao Shu, Mingjun Wu, Jun Wang, Jingyao Zhang, Rui Wang, Peng Li, Yitao Wang
BACKGROUND: Renal tubulointerstitial fibrosis (TIF) is commonly the final result of a variety of progressive injuries and leads to end-stage renal disease. There are few therapeutic agents currently available for retarding the development of renal TIF. PURPOSE: The aim of the present study is to evaluate the role of arctigenin (ATG), a lignan component derived from dried burdock (Arctium lappa L.) fruits, in protecting the kidney against injury by unilateral ureteral obstruction (UUO) in rats...
July 1, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28536123/randomized-controlled-trial-of-mineralocorticoid-receptor-blockade-in-children-with-chronic-kidney-allograft-nephropathy
#13
Mara Medeiros, Luis Velásquez-Jones, Ana M Hernández, Guillermo Ramón-García, Saúl Valverde, Yolanda Fuentes, Arindal Vargas, Mauricio Patiño, Rosalba Pérez-Villalva, Juan Antonio Ortega-Trejo, Jonatan Barrera-Chimal, Norma A Bobadilla
BACKGROUND AND OBJECTIVES: We showed that mineralocorticoid receptor blockade (MRB) prevented acute and chronic cyclosporine nephropathy (CsA-Nx) in the rat. The aim of this translational study was to investigate the effect of long-term eplerenone administration on renal allograft function in children with biopsy-proven chronic allograft nephropathy (CAN). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Renal transplant children <18 years, biopsy-proven CAN, and a GFR>40 ml/min per 1...
May 23, 2017: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/28462043/lack-of-riluzole-efficacy-in-the-progression-of-the-neurodegenerative-phenotype-in-a-new-conditional-mouse-model-of-striatal-degeneration
#14
Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Piotr Chmielarz, Monika Bagińska, Irena Nalepa
BACKGROUND: Huntington's disease (HD) is a rare familial autosomal dominant neurodegenerative disorder characterized by progressive degeneration of medium spiny neurons (MSNs) located in the striatum. Currently available treatments of HD are only limited to alleviating symptoms; therefore, high expectations for an effective therapy are associated with potential replacement of lost neurons through stimulation of postnatal neurogenesis. One of the drugs of potential interest for the treatment of HD is riluzole, which may act as a positive modulator of adult neurogenesis, promoting replacement of damaged MSNs...
2017: PeerJ
https://www.readbyqxmd.com/read/28460289/effect-of-environmental-conditions-on-the-permeability-of-low-density-polyethylene-film-and-totally-impermeable-film-to-methyl-isothiocyanate-fumigant
#15
REVIEW
Wensheng Fang, Aocheng Cao, Dongdong Yan, Dawei Han, Jun Li, Xiaoman Liu, Yuan Li, Chanbin Ouyang, Qiuxia Wang
Fumigant methyl isothiocyanate (MITC) is a very promising alternative to methyl bromide, providing effective control of soil borne disease. However, there is a significant volatilization of MITC following fumigation because of its high application rates and high vapor pressure. Covering the soil surface with plastic tarps is a common approach used for restricting fumigant emissions to the atmosphere. To minimize atmospheric emissions of MITC by tarping, we determined the effect of temperature, humidity, and fumigant mixtures on the permeability to MITC of low density polyethylene film (LDPE) and totally impermeable film (TIF), using static sealed chambers...
December 1, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28424731/identification-of-tify-family-genes-and-analysis-of-their-expression-profiles-in-response-to-phytohormone-treatments-and-melampsora-larici-populina-infection-in-poplar
#16
Wenxiu Xia, Hongyan Yu, Pei Cao, Jie Luo, Nian Wang
The TIFY domain contains approximately 36 conserved amino acids that form the core motif TIF[F/Y]XG, and they were reported to play important roles in plant growth, tissue development and defense regulation. Moreover, more and more evidence has shown that some members of the TIFY gene family perform their functions by modulating plant hormone signaling pathways. Poplar trees are found worldwide, and they comprise approximately 30 species. Benefit from the importance of poplar and its advanced platform, this tree is considered to be the model perennial plant...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28392772/the-tromso-infant-faces-database-tif-development-validation-and-application-to-assess-parenting-experience-on-clarity-and-intensity-ratings
#17
Jana K Maack, Agnes Bohne, Dag Nordahl, Lina Livsdatter, Åsne A W Lindahl, Morten Øvervoll, Catharina E A Wang, Gerit Pfuhl
Newborns and infants are highly depending on successfully communicating their needs; e.g., through crying and facial expressions. Although there is a growing interest in the mechanisms of and possible influences on the recognition of facial expressions in infants, heretofore there exists no validated database of emotional infant faces. In the present article we introduce a standardized and freely available face database containing Caucasian infant face images from 18 infants 4 to 12 months old. The development and validation of the Tromsø Infant Faces (TIF) database is presented in Study 1...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28370527/continuous-one-step-synthesis-of-porous-m-xf6-based-metal-organic-and-hydrogen-bonded-frameworks
#18
Vincent Guillerm, Luis Garzón-Tovar, Amirali Yazdi, Inhar Imaz, Jordi Juanhuix, Daniel Maspoch
Metal-organic frameworks (MOFs) built up from connecting M-XF6 pillars through N-donor ligands are among the most attractive adsorbents and separating agents for CO2 and hydrocarbons today. The continuous, one-step spray-drying synthesis of several members of this isoreticular MOF family varying the anionic pillar (XF6 =[SiF6 ](2-) and [TiF6 ](2-) ), the N-donor organic ligand (pyrazine and 4,4'-bipyridine) and the metal ion (M=Co, Cu and Zn) is demonstrated here. This synthetic method allows them to be obtained in the form of spherical superstructures assembled from nanosized crystals...
May 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28360124/genetic-mutations-linked-to-parkinson-s-disease-differentially-control-nucleolar-activity-in-pre-symptomatic-mouse-models
#19
Valentin Evsyukov, Andrii Domanskyi, Holger Bierhoff, Suzana Gispert, Rasem Mustafa, Falk Schlaudraff, Birgit Liss, Rosanna Parlato
Genetic mutations underlying neurodegenerative disorders impair ribosomal DNA (rDNA) transcription suggesting that nucleolar dysfunction could be a novel pathomechanism in polyglutamine diseases and in certain forms of amyotrophic lateral sclerosis/frontotemporal dementia. Here, we investigated nucleolar activity in pre-symptomatic digenic models of Parkinson's disease (PD) that model the multifactorial aetiology of this disease. To this end, we analysed a novel mouse model mildly overexpressing mutant human α-synuclein (hA53T-SNCA) in a PTEN-induced kinase 1 (PINK1/PARK6) knockout background and mutant mice lacking both DJ-1 (also known as PARK7) and PINK1...
May 1, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28334682/phytochemical-induced-nucleolar-stress-results-in-the-inhibition-of-breast-cancer-cell-proliferation
#20
Anna Lewinska, Diana Bednarz, Jagoda Adamczyk-Grochala, Maciej Wnuk
The nucleolus is a stress sensor and compromised nucleolar activity may be considered as an attractive anticancer strategy. In the present study, the effects of three plant-derived natural compounds, i.e., sulforaphane (SFN), ursolic acid (UA) and betulinic acid (BA) on nucleolar state were investigated in breast cancer cell lines of different receptor status, namely MCF-7, MDA-MB-231 and SK-BR-3 cells. Cytostatic action of phytochemicals against breast cancer cells was observed at low micromolar concentration window (5-20µM) and mediated by elevated p21 levels, and cell proliferation of SFN-, UA- and BA-treated normal human mammary epithelial cells (HMEC) was unaffected...
August 2017: Redox Biology
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