keyword
https://read.qxmd.com/read/38434586/expression-and-signiffcance-of-kim-1-ngal-and-ho-1-in-patients-with-acute-kidney-injury-after-cardiac-valve-replacement-letter
#21
JOURNAL ARTICLE
Yanyan Song, Jiwei Gu
No abstract text is available yet for this article.
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38434585/maresin-1-attenuates-sepsis-associated-acute-kidney-injury-via-suppressing-inflammation-endoplasmic-reticulum-stress-and-pyroptosis-by-activating-the-ampk-sirt3-pathway
#22
JOURNAL ARTICLE
Miaomiao Sun, Fuquan Wang, Haopeng Li, Mengyu Li, Yu Wang, Chenchen Wang, Yan Zhang, Dingyu Zhang, Jianhua Li, Shanglong Yao
BACKGROUND: Sepsis-associated acute kidney injury (SA-AKI) is a common complication in patients with sepsis, triggering high morbidity and mortality. Maresin-1 (MaR1) is a pro-resolution lipid mediator that promotes the resolution of acute inflammation and protects organs from inflammation. METHODS: In this study, we established an SA-AKI model using cecal ligation and puncture (CLP) and investigated the effect and mechanism of MaR1. The blood and kidneys were harvested 24 hours after surgery...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38428308/attenuation-of-carbon-tetrachloride-induced-nephrotoxicity-by-gum-arabic-extract-via-modulating-cellular-redox-state-nf-%C3%AE%C2%BAb-pathway-and-kim-1
#23
JOURNAL ARTICLE
Noha H Habashy, Marwa M Abu-Serie
The current study investigated the ameliorating impact of GA water extract (GAE) on CCl4 -induced nephrotoxicity in renal cells and tissue by comparing its effectiveness with the Ketosteril (Ks) drug in restoring oxidative stress and necroinflammation. The cell morphology, necrosis, and redox state were evaluated in Vero cells. The influence of GAE on CCl4 -induced oxidative stress, inflammation, and necrosis was examined in rats. The predicted inhibitory mechanism of GAE phenolic constituents against COX-2 and iNOS was also studied...
February 29, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38425055/disparity-of-serum-uric-acid-threshold-for-ckd-among-hypertensive-and-non-hypertensive-individuals
#24
JOURNAL ARTICLE
Bowen Zhu, Fang Li, Weidong Zhang, Shuan Zhao, Nana Song, Shi Jin, Ziyan Shen, Yufei Lu, Yang Li, Hong Liu
INTRODUCTION: Hypertension and rising serum uric acid (sUA) played a pivotal role in the development of Chronic Kidney Disease (CKD). This study investigates the interactive effect of sUA and hypertension on CKD and identifies the optimal threshold of sUA among individuals with and without hypertension in the Chinese community population. MATERIALS AND METHODS: The study included 4180 individuals aged 45-85 years, derived from the China Health and Retirement Longitudinal Study (CHARLS) between 2011 and 2015...
December 2024: Renal Failure
https://read.qxmd.com/read/38413110/safety-of-administering-intravenous-ct-contrast-agents-repeatedly-or-using-both-ct-and-mri-contrast-agents-on-the-same-day-an-animal-study
#25
JOURNAL ARTICLE
Heejin Bae, Hyewon Oh, Ga Bin Park, Yong Eun Chung
OBJECTIVE: To investigate molecular and functional consequences of additional exposures to iodine- or gadolinium-based contrast agents within 24 hours from the initial intravenous administration of iodine-based contrast agents through an animal study. MATERIALS AND METHODS: Fifty-six Sprague-Dawley male rats were equally divided into eight groups: negative control, positive control (PC) with single-dose administration of CT contrast agent, and additional administration of either CT or MR contrast agents 2, 4, or 24 hours from initial CT contrast agent injection...
March 2024: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://read.qxmd.com/read/38409569/hmgn1-down-regulation-in-the-diabetic-kidney-attenuates-tubular-cells-injury-and-protects-against-renal-inflammation-via-suppressing-mcp-1-and-kim-1-expression-through-tlr4
#26
JOURNAL ARTICLE
J Yu, J Da, F Yu, J Yuan, Y Zha
BACKGROUND: Renal tubular injury, accompanied by damaging inflammation, has been identified to drive diabetic kidney disease (DKD) toward end-stage renal disease. However, it is unclear how damage-associated molecular patterns (DAMPs) activate innate immunity to mediate tubular epithelial cell (TEC) injury, which in turn causes with subsequent sterile inflammation in diabetic kidneys. High mobility group nucleosome-binding protein 1 (HMGN1) is a novel DAMP that contributes to generating the innate immune response...
February 27, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38403348/-effect-and-mechanism-of-jiedu-huoxue-decoction-in-regulating-yap-acsl4-pathway-to-inhibit-ferroptosis-in-treatment-of-acute-kidney-injury
#27
JOURNAL ARTICLE
Ran Cheng, Rui-Min Tian, Li-Hua Huang, Xiao-Wan Wang, Shan Guo, Ai-Jun Wu, Chuang Li, Jing Chen, Shu-Ju Li, Ming Chen, Wei Mao, Peng Xu
Jiedu Huoxue Decoction(JDHX), first recorded in the Correction on Errors in Medical Works by WANG Qing-ren, is an effective formula screened out from ancient formulas by the traditional Chinese medicine(TCM) master ZHANG Qi to treat acute kidney injury(AKI) caused by heat, toxicity, stasis, and stagnation. This paper elucidated the therapeutic effect of JDHX on AKI and probed into the potential mechanism from ferroptosis. Thirty-two male C57BL/6 mice were randomized into four groups(n=8): normal, model, and low-and high-dose JDHX...
January 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://read.qxmd.com/read/38395179/network-pharmacology-and-experimental-validation-to-investigate-the-mechanism-of-nao-ling-su-capsule-in-the-treatment-of-ischemia-reperfusion-induced-acute-kidney-injury
#28
JOURNAL ARTICLE
Yongqiang Lin, Lili Xu, Huibin Lin, Weiliang Cui, Yang Jiao, Bing Wang, Huifen Li, Xiaojie Wang, Jichao Wu
ETHNOPHARMACOLOGICAL RELEVANCE: Nao-Ling-Su Capsule (NLSC) is a traditional prescription, which is composed of fifteen herbs such as epimedium, Polygala tenuifolia, and Schisandra chinensis. It has the effect of strengthening the brain, calming nerves, and protecting the kidney, which has been used clinically for many years to strengthen the brain and kidney. However, the effect of NLSC in the treatment of acute kidney injury (AKI) is still unclear. AIM OF THE STUDY: The present study aims to elucidate the pharmacological actions of NLSC in the treatment of AKI...
February 21, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38389296/urinary-concentration-of-renal-biomarkers-in-healthy-term-neonates-gender-differences-in-gst-pi-excretion
#29
JOURNAL ARTICLE
Monika Kamianowska, Agnieszka Rybi-Szumińska, Aleksandra Kamianowska, Mateusz Maciejczyk, Anna Zubrzycka, Joanna Nazarko, Anna Wasilewska
BACKGROUND Serum creatinine, the criterion standard in assessment of renal function, is not reliable for the neonatal period because of its dependence on renal immaturity and maternal creatinine levels. Thus, it is important to study other biomarkers of renal function in neonates. The present study aimed to measure the urinary concentration of renal biomarkers: calbindin, clusterin, GST-pi (glutathione-S-transferase-alpha), KIM-1 (kidney injury molecule 1), MCP-1 (monocyte chemoattractant protein-1), and B2M (beta 2-microglobulin) in healthy term neonates...
February 23, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38376274/protective-effect-of-rosmarinic-acid-on-the-transmembrane-transporter-ctr1-expression-in-cisplatin-treated-mice
#30
JOURNAL ARTICLE
Juheb Akhter, Poonam Goswami, Mirza Masroor Ali Beg, Shahzad Ahmad, Abul Kalam Najmi, Sheikh Raisuddin
AIMS: Cisplatin (cis-diamminedichloroplatinum(II), CP) is a platinum-based anticancer drug widely used in the treatment of solid malignancies. However, its side effects, particularly nephrotoxicity, are limiting factors in its clinic use. Rosmarinic acid (RA), a natural antioxidant compound, is reported to attenuate oxidative stress and associated pathophysiological outcomes. Our study aimed to explore the protective effect of RA against CP-induced acute kidney injury (AKI). MATERIALS AND METHODS: We investigated the effect of RA at the dose of 100 mg/kg on AKI induced by CP (20 mg/kg) in mice...
October 1, 2023: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/38365731/high-cd133-expression-in-proximal-tubular-cells-in-diabetic-kidney-disease-good-or-bad
#31
JOURNAL ARTICLE
Yuhan Zhang, Lusi Xu, Congcong Guo, Xianzhi Li, Yutian Tian, Lin Liao, Jianjun Dong
BACKGROUND: Proximal tubular cells (PTCs) play a critical role in the progression of diabetic kidney disease (DKD). As one of important progenitor markers, CD133 was reported to indicate the regeneration of dedifferentiated PTCs in acute kidney disease. However, its role in chronic DKD is unclear. Therefore, we aimed to investigate the expression patterns and elucidate its functional significance of CD133 in DKD. METHODS: Data mining was employed to illustrate the expression and molecular function of CD133 in PTCs in human DKD...
February 16, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38364601/sodium-aescinate-induces-renal-toxicity-by-promoting-nrf2-gpx4-mediated-ferroptosis
#32
JOURNAL ARTICLE
Haiyan Zhu, Yenan Duan, Yijing Yang, Enqing Chen, Hanxin Huang, Xi Wang, Jie Zhou
Sodium aescinate (SA) is extracted from Aesculus wilsonii Rehd seeds and was first marketed as a medicament in German. With the wide application of SA in clinical practice, reports of adverse drug reactions and adverse events have gradually increased, including renal impairment. However, the pathogenic mechanisms of SA have not yet been fully elucidated. The toxic effects and underlying mechanisms of SA were explored in this study. Our data showed that SA significantly elevated the levels of blood urea nitrogen (BUN), serum creatinine (Scr) and Kidney injury molecule 1 (Kim-1), accompanied by pathologically significant changes in renal tissue...
March 1, 2024: Chemico-biological Interactions
https://read.qxmd.com/read/38353655/sensing-dying-cells-in-health-and-disease-the-importance-of-kidney-injury-molecule-1
#33
JOURNAL ARTICLE
Elena Tutunea-Fatan, Shabitha Arumugarajah, Rita S Suri, Cassandra R Edgar, Ingrid Hon, Jimmy D Dikeakos, Lakshman Gunaratnam
Kidney Injury Molecule-1 (KIM-1), also known as T cell immunoglobulin and mucin domain-1 (TIM-1), is a widely recognized biomarker for acute kidney injury, but its biological function is less appreciated. KIM-1/TIM-1 belongs to the TIM family of conserved transmembrane proteins which bear the characteristic six-cysteine immunoglobulin-like (IgV) domain. The latter enables binding of KIM-1/TIM-1 to its natural ligand, phosphatidylserine, expressed on the surface of apoptotic cells and necrotic cells. KIM-1/TIM-1 is expressed in a variety of tissues and plays fundamental roles in regulating sterile inflammation and adaptive immune responses...
February 14, 2024: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/38351500/comparative-levels-of-urinary-biomarkers-of-renal-injury-and-inflammation-among-patients-with-diabetic-nephropathy-with-or-without-hyperuricemia
#34
JOURNAL ARTICLE
Ryan Alex, Ella Press, Lorin Sanchez, Jeremy Whitson, Brad Marder, James Alan Tumlin
BACKGROUND: The association between hyperuricemia and development of progressive chronic kidney disease has received increasing attention in recent years. Recent preclinical studies have shown that non-crystalline uric acid can induce renal-specific arteriolopathy, leading to renal injury and tubulointerstitial inflammation. METHODS: We conducted a open-label cross-sectional study of 25 patients with chronic kidney disease stage III (estimated glomerular filtration rate [eGFR], 7...
February 14, 2024: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://read.qxmd.com/read/38348719/effect-of-vinpocetine-against-acrylamide-induced-nephrotoxicity-in-rats
#35
JOURNAL ARTICLE
Doaa S Ibrahim
Vinpocetine (VIN) is a synthetic drug derived from the natural alkaloid vincamine. The antioxidation and anti-inflammation effects of VIN allow it to be used for multiple therapeutic purposes. So, the research aims to discover the possibility of using VIN to improve the nephrotoxicity of acrylamide (ACR). Twenty-four male albino rats were used in the trial: rats in the control group received 0.5 mL of oral saline, rats in the VIN group received an oral dose of VIN (5 mg/kg), rats in the ACR group received an oral dose of ACR (38...
February 2024: Journal of Biochemical and Molecular Toxicology
https://read.qxmd.com/read/38345758/metformin-protects-against-acute-kidney-injury-induced-by-lipopolysaccharide-via-up-regulating-the-mcpip1-sirt1-pathway
#36
JOURNAL ARTICLE
Wen-Long Zhang, Long-Jun Zhang, Piao Liang, Hui-Long Fang, Xiao-Li Wang, Yan-Juan Liu, Hua-Fei Deng
In the present study, we aimed to explore the effect and underlying mechanism of metformin on lipopolysaccharide (LPS)-induced acute kidney injury (AKI). A total of 24 BALB/C mice were randomly divided into four groups: control group, LPS group and metformin group (50 or 100 mg/kg). The histological changes and cell apoptosis in kidney tissues were detected by hematoxylin-eosin staining and terminal-deoxynucleotidyl transferase-mediated nick end labeling assay, respectively. Enzyme-linked immunosorbent assay was applied to determine serum levels of blood urea nitrogen (BUN), kidney injury molecule-1 (Kim-1), creatinine (Cre), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β)...
February 12, 2024: Biochemical Genetics
https://read.qxmd.com/read/38325794/the-therapeutic-effect-of-picroside-ii-in-renal-ischemia-reperfusion-induced-acute-kidney-injury-an-experimental-study
#37
JOURNAL ARTICLE
Ling Ren, Yuzhuo Zhao, Xianpu Ji, Wenqing Li, Wenli Jiang, Qiuyang Li, Lianhua Zhu, Yukun Luo
The microcirculation hemodynamics change and inflammatory response are the two main pathophysiological mechanisms of renal ischemia-reperfusion injury (IRI) induced acute kidney injury (AKI). The treatment of microcirculation hemodynamics and inflammatory response can effectively alleviate renal injury and correct renal function. Picroside II (P II) has a wide range of pharmacological effects. Still, there are few studies on protecting IRI-AKI, and whether P II can improve renal microcirculation perfusion is still being determined...
February 5, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38325526/protective-effects-and-mechanisms-of-dapagliflozin-on-renal-ischemia-reperfusion-injury
#38
JOURNAL ARTICLE
Qiuxiao-Zhu, Huiyao-Hao, Na Li, Zibo-Liu, Qian-Wang, Linyi-Shu, Lihui-Zhang
BACKGROUND: Renal diseases have a significant negative impact on human health and the quality of life. Renal ischemia/reperfusion (I/R) injury is considered as one of the leading causes of renal dysfunction and tissue damage. Oxidative stress and inflammation are responsible for cellular apoptosis playing critical roles in renal I/R injury. Recent studies suggested that dapagliflozin-a medication used to treat Type 2 Diabetes-may exert protective effects on I/R injury in kidneys by alleviating oxidative stress and inflammation...
February 5, 2024: Transplant Immunology
https://read.qxmd.com/read/38306918/aminoguanidine-alleviates-gout-in-goslings-experimentally-infected-with-goose-astrovirus-2-by-reducing-kidney-lesions
#39
JOURNAL ARTICLE
Ming Zhu, Zixuan Guo, Haoran Xu, Xinyang Li, Hongbo Chen, Ruibing Cao, Yingjun Lv
Goose astrovirus (GAstV)-2, a novel pathogen identified in 2018, mainly causes visceral gout in goslings, leading to approximately 50% mortality. At present, no commercial veterinary products are available to prevent and treat the disease. Our previous studies showed that nitric oxide (NO) and inducible NO synthase (iNOS) were markedly higher in the kidney and spleen of goslings infected with GAstV-2, but their effects during GAstV-2 infection remain unclear. In the present study, goslings were intraperitoneally injected with aminoguanidine (AG)-an iNOS inhibitor-to examine the role of NO during GAstV-2 infection...
January 20, 2024: Poultry Science
https://read.qxmd.com/read/38304804/thymoquinone-alleviates-cisplatin-induced-kidney-damage-by-reducing-apoptosis-in-a-rat-model
#40
JOURNAL ARTICLE
Shuai Li, Zhanxue Zhao
PURPOSE: The aim of the study was to compare the ameliorating effects of thymoquinone at various dosages on cisplatin-induced renal toxicity, and to investigate its effects on cisplatin-induced nephrocyte apoptosis via the mitochondrial pathway in a rat model. METHODS: A rat model of cisplatin-induced renal damage was established, with thymoquinone treatment groups (receiving 1, 3, 5, 10, or 20 mg/kg of thymoquinone). We determined serum creatinine (Cr) and blood urea nitrogen (BUN), measured the expression of the anti-apoptotic protein Bcl-2, the pro-apoptotic protein Bax, caspase-3, kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in renal tissue...
January 30, 2024: Heliyon
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