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https://www.readbyqxmd.com/read/27912887/nephroprotective-effects-of-%C3%AE-bisabolol-against-ischemic-reperfusion-acute-kidney-injury
#1
Tiago Lima Sampaio, Ramon Róseo Paula Pessoa Bezerra de Menezes, Marcus Felipe Bezerra da Costa, Gdayllon Cavalcante Meneses, Mauren Cristina Villalta Arrieta, Adriano José Maia Chaves Filho, Glayciane Bezerra de Morais, Alexandre Braga Libório, Renata Sousa Alves, Janaína Serra Azul Monteiro Evangelista, Alice Maria Costa Martins
BACKGROUND: Ischemia/reperfusion (I/R) in kidney is commonly related to acute kidney injury (AKI), essentially through oxidative stress. (-)-α-Bisabolol is a sesquiterpene isolated from the essential oil of a variety of plants, including chamomile, which has important antioxidant activity. STUDY DESIGN: This study intends to evaluate the nephroprotective activity of (-)-α-bisabolol (Bis) in both in vivo and in vitro models of kidney I/R. METHODS: Male Wistar rats were submitted to right nephrectomy, followed by ischemia by clamping of the renal artery in the left kidney for 60min...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27907168/are-urinary-tubular-injury-markers-useful-in-chronic-kidney-disease-a-systematic-review-and-meta-analysis
#2
Le-Ting Zhou, Lin-Li Lv, Ming-Ming Pan, Yu-Han Cao, Hong Liu, Ye Feng, Hai-Feng Ni, Bi-Cheng Liu
BACKGROUND: Adverse outcome of chronic kidney disease, such as end stage renal disease, is a significant burden on personal health and healthcare costs. Urinary tubular injury markers, such as NGAL, KIM-1 and NAG, could provide useful prognostic value for the early identification of high-risk patients. However, discrepancies between recent large prospective studies have resulted in controversy regarding the potential clinical value of these markers. Therefore, we conducted the first meta-analysis to provide a more persuasive argument to this debate...
2016: PloS One
https://www.readbyqxmd.com/read/27895157/beneficial-effects-of-myo-inositol-oxygenase-deficiency-in-cisplatin-induced-aki
#3
Rajesh K Dutta, Vinay K Kondeti, Isha Sharma, Navdeep S Chandel, Susan E Quaggin, Yashpal S Kanwar
Overexpression of the proximal tubular enzyme myo-inositol oxygenase (MIOX) induces oxidant stress in vitro However, the relevance of MIOX to tubular pathobiology remains enigmatic. To investigate the role of MIOX in cisplatin-induced tubular AKI, we generated conditional MIOX-overexpressing transgenic (MIOX-TG) mice and MIOX-knockout (MIOX(-/-)) mice with tubule-specific MIOX overexpression or knockout, respectively. Compared with cisplatin-treated wild-type (WT) mice, cisplatin-treated MIOX-TG mice had even greater increases in urea, creatinine, and KIM-1 levels and more tubular injury and apoptosis, but these effects were attenuated in cisplatin-treated MIOX(-/-) mice...
November 28, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27889773/evaluation-of-kim-1-and-ngal-as-early-indicators-for-assessment-of-gentamycin-induced-nephrotoxicity-in-vivo-and-in-vitro
#4
Qi-Hui Luo, Meng-Lu Chen, Zheng-Li Chen, Chao Huang, An-Chun Cheng, Jing Fang, Li Tang, Yi Geng
BACKGROUND/AIMS: The aminolycoside Gentamicin is a widely used antibiotic, applied in equine medicine. Despite its clinical use, concerns remain regarding the potential toxic side-effects, such as nephrotoxicity. Early detection of renal damage is critical in preclinical drug development. This study was aimed to determine whether kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) may be early indicators in the assessment of Gentamycin-induced nephrotoxicity...
November 28, 2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27876501/serum-and-urinary-biomarkers-that-predict-hepatorenal-syndrome-in-patients-with-advanced-cirrhosis
#5
Desmond Y H Yap, Wai Kay Seto, James Fung, Siu Ho Chok, See Ching Chan, Gary C W Chan, Man Fung Yuen, Tak Mao Chan
BACKGROUND: Prediction of hepatorenal syndrome (HRS) remains difficult in advanced cirrhotic patients. AIMS: To evaluate use of serum and urine biomarkers to predict HRS. METHODS: We prospectively recruited Child's B or C cirrhotic patients with normal serum creatinine, and followed them for 12 weeks for the development of HRS. Serum Cystatin C (CysC), serum and urine Neutrophil Gelatinase-Associated Lipocalin (NGAL), serum and urine IL-18, serum N-acetyl-β-d glucosaminidase (NAG), urine kidney injury molecule-1 (KIM-1) and urine liver-type fatty acid binding protein (LFABP) were measured at recruitment (baseline), and their relationship with subsequent HRS investigated...
November 10, 2016: Digestive and Liver Disease
https://www.readbyqxmd.com/read/27862656/matrix-metalloproteinase-12-mmp-12-deficiency-attenuates-experimental-crescentic-anti-gbm-glomerulonephritis
#6
Abu P Abraham, Frank Y Ma, William R Mulley, David J Nikolic-Paterson, Greg H Tesch
AIM: MMP-12 (macrophage elastase) is an enzyme that can cleave various extracellular matrix proteins and is required for macrophage infiltration and pulmonary fibrosis in experimental emphysema. We have shown previously that MMP-12 is highly up-regulated in experimental anti-glomerular basement membrane (GBM) disease. The aim of this study was to determine whether MMP-12 is required for glomerular macrophage infiltration and crescent formation in anti-GBM glomerulonephritis. METHODS: Accelerated anti-GBM disease was induced in groups of MMP-12 gene deficient mice (MMP-12-/-) and wild type C57BL/6 J (WT) controls, which were killed 12 days after injection of anti-GBM serum...
November 8, 2016: Nephrology
https://www.readbyqxmd.com/read/27858892/circulating-kidney-injury-molecule-1-is-a-novel-diagnostic-biomarker-for-renal-dysfunction-during-long-term-adefovir-therapy-in-chronic-hepatitis-b
#7
Ziyue Li, Chuan Shen, Yadong Wang, Wei Wang, Qian Zhao, Zhenzhong Liu, Yang Wang, Caiyan Zhao
The aim of this study was to evaluate serum kidney injury molecule-1 (KIM-1) as a new diagnostic marker of renal dysfunction in chronic hepatitis B (CHB) patients receiving long-term adefovir dipivoxil (ADV) treatment.We retrospectively enrolled 85 patients treated with ADV and 85 patients treated with entecavir (ETV) monotherapy, for at least 6 months. The 2 groups were matched for baseline age (± 5 years), sex, and estimated glomerular filtration rate (eGFR). Serum creatinine, cystatin C, and KIM-1 concentrations were measured, and eGFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) creatinine-cystatin C equation, at baseline and last follow-up...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27852120/kim-1-is-a-potential-urinary-biomarker-of-obstruction-results-from-a-prospective-cohort-study
#8
Daniel Olvera-Posada, Thamara Dayarathna, Marie Dion, Husain Alenezi, Alp Sener, John D Denstedt, Stephen E Pautler, Hassan Razvi
INTRODUCTION: Partial or complete obstruction of the urinary tract is a common and challenging urological condition that may occur in patients of any age. Serum creatinine is the most commonly used method to evaluate global renal function, although it has low sensitivity for early changes in the glomerular filtration rate or unilateral renal pathology. Hence, finding another measurable parameter that reflects the adaptation of the renal physiology to these circumstances is important. Several recent studies have assessed the use of new biomarkers of Acute Kidney Injury (AKI), but the information among patients with stone disease and those with obstructive uropathy is limited...
November 16, 2016: Journal of Endourology
https://www.readbyqxmd.com/read/27850932/1296-kinetics-of-ngal-and-kim-1-in-plasma-and-urine-after-intravenous-contrast-in-adult-icu-patients
#9
Mohan Gurjar, Vikas Agarwal, Harshit Singh, Saurabh Chaturvedi, Ravi Mishra, Pralay Ghosh, Sai Pv, Arvind Baronia
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27830181/the-role-of-activin-a-and-b-and-the-benefit-of-follistatin-treatment-in-renal-ischemia-reperfusion-injury-in-mice
#10
Doreen Y P Fang, Bo Lu, Susan Hayward, David M de Kretser, Peter J Cowan, Karen M Dwyer
BACKGROUND: Activins, members of the TGF-β superfamily, are key drivers of inflammation and are thought to play a significant role in ischemia-reperfusion injury (IRI), a process inherent to renal transplantation that negatively impacts early and late allograft function. Follistatin (FS) is a protein that binds activin and inhibits its activity. This study examined the response of activin A and B in mice after renal IRI and the effect of exogenous FS in modulating the severity of renal injury...
July 2016: Transplantation Direct
https://www.readbyqxmd.com/read/27829992/hmgb1-tlr4-signaling-participates-in-renal-ischemia-reperfusion-injury-and-could-be-attenuated-by-dexamethasone-mediated-inhibition-of-the-erk-nf-%C3%AE%C2%BAb-pathway
#11
Jiong Zhang, Jumei Xia, Ying Zhang, Fang Xiao, Jin Wang, Hongyu Gao, Yanyan Liu, Song Rong, Ying Yao, Gang Xu, Junhua Li
Studies have shown that the HMGB1-TLR4 (High-mobility group protein B1, toll-like receptor 4) pathway participates in renal ischemic reperfusion injury (IRI) and that dexamethasone (DEX) could protect the kidney against IRI. This study aims to examine the protective effects of DEX on renal IRI and further explore the possible mechanism of action. During mouse renal IRI, HMGB1-TLR4 signals changed markedly including HMGB1 translocation and TLR4 up-regulation, resulting in histological damage and an increase in MPO expression...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27801416/-evaluation-of-markers-for-renal-graft-dysfunction-in-patients-with-type-1-diabetes-mellitus-after-kidney-transplantation-and-simultaneous-pancreas-kidney-transplantation
#12
A M Glazunova, M S Arutyunova, E V Tarasov, L V Nikankina, A V Il'in, M Sh Shamkhalova, M V Shestakova, Ya G Moisyuk
AIM: To study the markers of renal graft dysfunction in patients with type 1 diabetes mellitus (T1DM) after kidney transplantation (KT) and simultaneous pancreas-kidney transplantation (SPKT). SUBJECTS AND METHODS: The investigation enrolled 20 patients after successful SPKT and 41 patients after KT (of them 21 received continuous subcutaneous insulin infusion with an insulin doser; 20 had multiple insulin injections). The periods after KT and SPKT at patient inclusion were 8 (7; 8) and 11 (8; 18) months, respectively...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27798535/urinary-biomarkers-are-associated-with-severity-and-mechanism-of-injury
#13
Jud C Janak, Ian J Stewart, Jonathan A Sosnov, Jeffrey T Howard, Edward D Siew, Mallory M Chan, Nancy Wickersham, T Alp Ikizler, Kevin K Chung
Combat-related blast trauma results in massive tissue injury and tends to involve multiple systems. Further, an acute measure of injury severity based on underlying biological mechanisms may be important for the triage and treatment of these types of patients. We hypothesized that urinary biomarkers (UBs) would reflect severity of injury and that they would be elevated for blast injuries compared to gunshot wounds (GSW) in a cohort of combat casualties. We also postulated that UBs would be higher in patients with burns compared to patients with non-burn trauma in a civilian cohort...
October 26, 2016: Shock
https://www.readbyqxmd.com/read/27796342/single-multiplex-detection-of-organ-injury-biomarkers-using-spri-based-nano-immunosensor
#14
Effat Zeidan, Siqi Li, Zhiguo Zhou, Jennifer Miller, Marinella G Sandros
The clinical assessment of multiple organ dysfunctions at early stages is recognized to be an important factor in prompting definitive treatment decisions that prevent irreversible organ damage. In this article, we propose a real-time, label-free, and multiplex nanoenhanced SPRi platform to quantitatively assess two biomarkers, kidney injury molecule (KIM-1) and high mobility group box-1 (HMGB-1) simultaneously in buffer. Our work involves three major contributions in the design of the immunosensor: (1) we applied site-specific immobilization of antibodies to the solid surface that avoids loss of biological activity caused by covalent attachment; (2) we constructed a well-blocked sensor surface that exhibits minimal non-specific adsorption for singleplex measurements of each biomarker in buffer; and (3) we adopted a sandwich assay that implements functionalized quantum dots (NanoEnhancers) as signal amplifiers to achieve a sensitivity level of 5 pg/mL for KIM-1 and HMGB-1 in buffer...
October 31, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27788160/storage-time-and-urine-biomarker-levels-in-the-assess-aki-study
#15
Kathleen D Liu, Edward D Siew, W Brian Reeves, Jonathan Himmelfarb, Alan S Go, Chi-Yuan Hsu, Michael R Bennett, Prasad Devarajan, T Alp Ikizler, James S Kaufman, Paul L Kimmel, Vernon M Chinchilli, Chirag R Parikh
BACKGROUND: Although stored urine samples are often used in biomarker studies focused on acute and chronic kidney disease, how storage time impacts biomarker levels is not well understood. METHODS: 866 subjects enrolled in the NIDDK-sponsored ASsessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Study were included. Samples were processed under standard conditions and stored at -70°C until analyzed. Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and liver fatty acid binding protein (L-FABP) were measured in urine samples collected during the index hospitalization or an outpatient visit 3 months later...
2016: PloS One
https://www.readbyqxmd.com/read/27774409/pharmacokinetics-and-renal-toxicity-of-monomeric-amphotericin-b-in-rats-after-a-multiple-dose-regimen
#16
Jeong Yeon Kang, Jieming Gao, Dae Hwan Shin, Celeste Alvarez, Weixiong Zhong, Glen S Kwon
BACKGROUND: Delivery of monomeric Amphotericin B (AmB), i.e. deaggregated AmB, has been a major tactic in the reduction of renal toxicity at a membrane level, taking advantage of the selectivity of monomeric AmB for binding ergosterol over cholesterol. OBJECTIVE: The aim of this study was to characterize the pharmacokinetic (PK) and renal toxicity of monomeric AmB in rats following a multiple dose regimen. METHOD: AmB existed primarily in a monomeric state in poly(ethylene glycol)-block-poly(N-hexyl stearate L-aspartamide) (PEG-b-PHSA) micelles (mAmB) at 2:1 ratio (mol:mol), whereas AmB as its standard formulation, Fungizone(®), was highly self-aggregated based on absorption spectroscopy...
2016: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/27771693/kidney-injury-marker-1-and-neutrophil-gelatinase-associated-lipocalin-in-chronic-kidney-disease
#17
Esmeralda Castillo-Rodriguez, Raul Fernandez-Prado, Catalina Martin-Cleary, Maria Soledad Pizarro-Sánchez, Maria Dolores Sanchez-Niño, Ana Belen Sanz, Beatriz Fernandez-Fernandez, Alberto Ortiz
The current categorization of chronic kidney disease (CKD) is based on biomarkers of the glomerular function (estimated glomerular filtration rate, eGFR) and injury (urinary albumin creatinine ratio, UACR) and provides information on the risk of death and of progression of kidney disease. However, there are gaps in knowledge regarding the risk stratification of elderly patients with eGFR 45-60 ml/min/1.73 m2 and of younger patients with higher eGFR but physiological albuminuria. In this regard, most of the kidney cell mass is composed of tubules...
October 22, 2016: Nephron
https://www.readbyqxmd.com/read/27758121/kidney-injury-molecule-1-in-kidney-disease
#18
Caixia Yin, Ningning Wang
Kidney injury molecule-1(KIM-1) is a type I membrane protein, comprising an extracellular portion and a cytoplasmic portion, which is expressed at very low levels in the normal kidney. The extracellular portion can cleave and rapidly enter tubule lumens after kidney injury, and can then be detected in the urine. It has been confirmed that the urine KIM-1 level is closely related to tissue KIM-1 level and correlated with kidney tissue damage. Not only is KIM-1 proven to be an early biomarker of acute kidney injury but it also has a potential role in predicting long-term renal outcome...
October 19, 2016: Renal Failure
https://www.readbyqxmd.com/read/27756197/protective-effect-of-l-glutamine-against-diabetes-induced-nephropathy-in-experimental-animal-role-of-kim-1-ngal-tgf-%C3%AE-1-and-collagen-1
#19
Smeeta Sadar, Dipti Kaspate, Neeraj Vyawahare
Diabetic nephropathy is a serious microvascular complication and one of the main causes of end-stage renal disease. L-Glutamine (LG) is naturally occurring amino acids with antidiabetic and antioxidant potential. The aim of present investigation was to evaluate the potential of LG against streptozotocin (STZ)-induced diabetic nephropathy (DN) in laboratory rats. DN was induced in male Wistar rats (200-220 g) by intraperitoneal administration of STZ (55 mg/kg). Animals were treated orally with either distilled water (10 mg/kg) or LG (250, 500, and 1000 mg/kg) or Sitagliptin (5 mg/kg)...
October 2016: Renal Failure
https://www.readbyqxmd.com/read/27754425/ouabain-contributes-to-kidney-damage-in-a-rat-model-of-renal-ischemia-reperfusion-injury
#20
Luca Villa, Roberta Buono, Mara Ferrandi, Isabella Molinari, Fabio Benigni, Arianna Bettiga, Giorgia Colciago, Masami Ikehata, Elisabetta Messaggio, Maria Pia Rastaldi, Francesco Montorsi, Andrea Salonia, Paolo Manunta
Warm renal ischemia performed during partial nephrectomy has been found to be associated with kidney disease. Since endogenous ouabain (EO) is a neuro-endocrine hormone involved in renal damage, we evaluated the role of EO in renal ischemia-reperfusion injury (IRI). We measured plasma and renal EO variations and markers of glomerular and tubular damage (nephrin, KIM-1, Kidney-Injury-Molecule-1, α1 Na-K ATPase) and the protective effect of the ouabain inhibitor, rostafuroxin. We studied five groups of rats: (1) normal; (2) infused for eight weeks with ouabain (30 µg/kg/day, OHR) or (3) saline; (4) ouabain; or (5) saline-infused rats orally treated with 100 µg/kg/day rostafuroxin for four weeks...
October 14, 2016: International Journal of Molecular Sciences
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