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Neonatal hyperbilirubinemia

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https://www.readbyqxmd.com/read/28730953/an-update-on-predicting-severe-hyperbilirubinemia-and-bilirubin-neurotoxicity-risks-in-neonates
#1
Tom Newman, M Jeffrey Maisels
Extreme hyperbilirubinemia and kernicterus, though rare, continue to occur despite the adoption of universal screening. Unless they are known to have glucose-6-phosphate dehydrogenase deficiency, infants who currently develop kernicterus in high resource countries are often otherwise healthy newborns discharged from the well-baby nursery. In this review, we highlight risk factors that increase the risk of a newborn ≥35 weeks gestational age developing severe hyperbilirubinemia, as well as the risk factors that increase the hyperbilirubinemic infant's risk of kernicterus...
July 20, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28721815/conjunctival-icterus-an-important-but-neglected-sign-of-clinically-relevant-hyperbilirubinemia-in-jaundiced-neonates
#2
Jon Freeman Watchko, Abeer Azzuqa
BACKGROUND: Conjunctival icterus is a largely neglected physical sign that may be helpful in identifying neonates with clinically relevant hyperbilirubinemia by practitioners in the hospital and outpatient clinic or parents at home. OBJECTIVE: A recent NICU based study reported that conjunctival icterus is often a sign of significant (TSB ≥ 17 mg/dl) hyperbilirubinemia and TSB levels ≥ 76th-95th percentile on the Bhutani nomogram. In contrast, others report that conjunctival icterus, although frequently present at high TSB levels, may also be detected at lower TSB concentrations; suggesting instead that its absence may help to rule out significant hyperbilirubinemia...
July 18, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28721812/update-on-phototherapy-in-jaundiced-neonates
#3
Finn Ebbesen, Thor Willy Ruud Hansen, M Jeffrey Maisels
BACKGROUND: Even relatively low serum bilirubin concentrations can cause neurodevelopmental impairment in extremely low birth weight (EBWL) infants, while sequelae from hyperbilirubinemia in late preterm and term infants are rare and occur only at very high serum bilirubin lev-els. Phototherapy is the current treatment of choice. OBJECTIVE: To present an update on the most important issues involved in phototherapy for jaundiced infants. RESULTS: Light absorption by bilirubin in the skin transforms the native Z,Z-bilirubin to conformational photoisomers Z,E-bilirubin and E,Z-bilirubin and structural photoisomers E,Z-lumirubin and E,E-lumirubin...
July 18, 2017: Current Pediatric Reviews
https://www.readbyqxmd.com/read/28715820/therapeutic-plasma-exchange-in-neonates-and-infants-successful-use-of-a-miniaturized-machine
#4
Enrico Vidal, Francesco Garzotto, Mattia Parolin, Chiara Manenti, Anna Zanin, Massimo Bellettato, Giuseppe Remuzzi, Stuart L Goldstein, Luisa Murer, Claudio Ronco
Therapeutic plasma exchange (TPE) in neonates and small infants is a treatment method at the forefront that may become a potentially life-saving procedure in a wide array of severe conditions. Indications for TPE in the pediatric population have been mainly derived from adult literature, with neonatal hyperbilirubinemia being the most notable exception. The only alternative to TPE in small pediatric patients is manual blood exchange transfusion, which, however, bears an unacceptably high risk of severe complications...
2017: Blood Purification
https://www.readbyqxmd.com/read/28708286/baseline-diameters-of-inferior-vena-cava-and-abdominal-aorta-measured-by-ultrasonography-in-healthy-term-neonates-during-early-neonatal-adaptation-period
#5
Anna Jarosz-Lesz, Katarzyna Michalik, Iwona Maruniak-Chudek
OBJECTIVES: To evaluate normative sonographic measurements of the inferior vena cava (IVC), aorta (Ao), and IVC/Ao ratio in the first 2 days of life in term neonates. METHODS: We prospectively observed 200 term (more than 36 and 6/7 weeks of gestation), single, healthy neonates born in a city hospital. The exclusion criteria were congenital abnormalities, an Apgar score of less than 8, and hyperbilirubinemia requiring phototherapy. Maximum IVC (distal to the hepatic-IVC junction) and Ao (above the superior mesenteric artery) diameters were measured in the first 2 days of life in the longitudinal plane...
July 14, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28707558/effect-of-unconjugated-hyperbilirubinemia-on-neonatal-autonomic-functions-evaluation-by-heart-rate-variability
#6
Rahmi Ozdemir, Ozgur Olukman, Cem Karadeniz, Kiymet Celik, Nagehan Katipoglu, Murat Muhtar Yilmazer, Sebnem Calkavur, Timur Mese, Sertac Arslanoglu
BACKGROUND: Beyond the physiological levels of bilirubin may leads to alterations in autonomic regulation. Heart rate variability (HRV), is a noninvasive and quantitative marker of the activity of the autonomic nervous system (ANS). To date, few studies have been evaluated the undesirable effects of severe unconjugated hyperbilirubinemia (UHB) on autonomic functions, and only one study has used HRV as a marker of the autonomic activity. However, the relationship between altered cardiac autonomic functions and UHB by using the HRV derived from 24-hour Holter electrocardiography (ECG) recording previously...
July 14, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28692551/can-exchange-transfusion-normalize-serum-levels-of-copper-zinc-and-magnesium-in-severe-neonatal-hyperbilirubinemia
#7
Reem A Abdel Aziz, Abdel-Azeem M El-Mazary, Ahmed A Saidii
BACKGROUND: Neonatal hyperbilirubinemia is a frequently encountered problem. Erythrocytes, especially reticulocytes are rich in copper (Cu) and magnesium (Mg) so its serum levels increase after hemolysis. Zinc (Zn) plays an important role in synthesis of some enzymes included in the bilirubin metabolism and may cause hemolysis. Exchange transfusion is the main treatment for severe neonatal hyperbilirubinemia but can exchange transfusion affect the previous trace elements. MATERIALS AND METHODS: We measured Cu, Zn, and Mg serum levels in full-term neonates admitted to neonatal intensive care unit of Minia University hospital with severe indirect hyperbilirubinemia before and after exchange transfusion...
July 7, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28687948/role-of-hepatobiliary-scintigraphy-and-preoperative-liver-biopsy-for-exclusion-of-biliary-atresia-in-neonatal-cholestasis-syndrome
#8
Ankur Mandelia, Richa Lal, Nijagal Mutt
All diagnostic algorithms for Neonatal Cholestasis Syndrome (NCS) focus on differentiating numerous medical causes from Biliary Atresia (BA). No preoperative diagnostic algorithm has 100% diagnostic accuracy for BA and yet, timely diagnosis is crucial to optimize surgical outcome. Markers for high index of clinical suspicion for BA are: a "usually" well thriving infant with conjugated hyperbilirubinemia, raised gamma glutamyl transpeptidase, persistently "acholic" stools, firm hepatomegaly with dysmorphic, hypoplastic gall bladder...
July 8, 2017: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/28682315/congenital-syphilis-in-neonates-with-nonreactive-nontreponemal-test-results
#9
P S Wozniak, J B Cantey, F Zeray, N K Leos, J S Sheffield, G D Wendel, P J Sánchez
OBJECTIVE: Infants whose mothers had syphilis during pregnancy were studied to determine how often exposed newborns with normal physical examinations and nonreactive nontreponemal serologic tests had abnormal laboratory or radiographic studies. STUDY DESIGN: Retrospective analysis of prospectively collected data from infants born to mothers with syphilis and had a normal examination and a nonreactive nontreponemal test. Some infants had IgM immunoblotting, PCR testing or rabbit infectivity testing (RIT) performed...
July 6, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28675983/fluid-supplementation-in-management-of-neonatal-hyperbilirubinemia-a-randomized-controlled-trial
#10
Prachi Goyal, Akshay Mehta, Jasbinder Kaur, Suksham Jain, Vishal Guglani, Deepak Chawla
OBJECTIVE: To evaluate the efficacy of oral or intravenous fluid supplementation in accelerating the decline of serum bilirubin with intensive phototherapy among healthy term and late preterm neonates with hyperbilirubinemia. STUDY DESIGN: This open-label randomized controlled trial randomized neonates with severe hyperbilirubinemia (serum total bilirubin ≥18 mg/dL or within 2 mg/dL of threshold for exchange transfusion) to receive 50 mL/kg of intravenous fluid over 8 h (IVF group, n = 51), 50 mL of oral rehydration solution over 8 h (oral rehydration solution (ORS) group, n = 50) or only standard therapy (control group, n = 49)...
July 20, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28665446/first-experience-on-bilirubin-removal-with-a-hemoadsorption-column-lixelle%C3%A2-in-a-child-with-cardiogenic-liver-injury
#11
Gabriella Bottari, Andrea Moscatelli, Enrico E Verrina, Franco Lerzo, Fabio S Taccone
INTRODUCTION: Hyperbilirubinemia may have deleterious effects on many organs, even after the neonatal age. Blood purification is effective in the treatment of hyperbilirubinemia. Recently some reports suggest the potential role of hemoadsorption columns in this setting. METHODS: We present the case of a 6-year-old child with severe hyperbilirubinemia due to congestive liver dysfunction, complicated by persistent inflammation, immunosuppression and catabolism syndrome (PICS)...
June 20, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/28662083/report-about-term-infants-with-severe-hyperbilirubinemia-undergoing-exchange-transfusion-in-southwestern-china-during-an-11-year-period-from-2001-to-2011
#12
Canfeng Yu, Huifan Li, Qiannan Zhang, Huayun He, Xinhong Chen, Ziyu Hua
OBJECTIVES: This study was intended to explore the etiology and risk factors of severe neonatal hyperbilirubinemia and to analyze the adverse events associated with ECT (Exchange Transfusion), as well as to identify the factors related to the poor prognosis. METHODS: All of the full-term neonates who had undergone ECT for hyperbilirubinemia at Children's Hospital of Chongqing Medical University from January 2001 to December 2011 were enrolled in this study. General demographic characteristics, comorbidities, pre- and post-exchange TSB(Total Serum Bilirubin) levels, duration and frequency of ECT, and clinical outcomes were recorded and analyzed anonymously...
2017: PloS One
https://www.readbyqxmd.com/read/28656812/annals-express-effects-of-bilirubin-photoisomers-on-the-measurement-of-direct-bilirubin-by-the-bilirubin-oxidase-method
#13
Hitoshi Okada, Kou Kawada, Susumu Itoh, Miyo Ozaki, Isami Kakutani, Takeshi Arai, Kosuke Koyano, Saneyuki Yasuda, Takashi Iwase, Koji Murao, Takashi Kusaka
BACKGROUND: We occasionally encounter increases in direct bilirubin(DB) value on reanalysis of the surplus serum collected in the past from a neonate with indirect hyperbilirubinemia. But the details of this phenomenon are unclear. We evaluated the change of DB and the relation of bilirubin photoisomer of the serum exposed to room light. METHODS: Surplus sera from neonates with indirect hyperbilirubinemia were exposed to room light for 24 hours. The bilirubin fraction assay of samples was performed by the bilirubin oxidase method (Nescauto and Aqua-auto Kainos reagent) and high-performance liquid chromatography ...
January 1, 2017: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/28617443/bilirubin-neurotoxicity-is-associated-with-proteasome-inhibition
#14
Hongbiao Huang, Mingxing Guo, Ningning Liu, Chong Zhao, Haoyu Chen, Xiaoli Wang, Siyan Liao, Ping Zhou, Yuning Liao, Xin Chen, Xiaoying Lan, Jinghong Chen, Dacai Xu, Xiaofen Li, Xianping Shi, Li Yu, Yuqiang Nie, Xuejun Wang, Chang-E Zhang, Jinbao Liu
The molecular mechanism underlying bilirubin neurotoxicity remains obscure. Ubiquitin-proteasome system-mediated proteolysis is pivotal to virtually all cellular processes and cell survival. Here we report for the first time that bilirubin at a clinically relevant elevated level impairs proteasomal function via inhibiting both the 19S proteasome-associated deubiquitinases (USP14 and UCHL5) and the chymotrypsin-like (CT-like) peptidase activity of 20S proteasomes, thereby contributing to bilirubin neurotoxicity...
June 15, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28617429/comparison-between-bilistick-system-and-transcutaneous-bilirubin-in-assessing-total-bilirubin-serum-concentration-in-jaundiced-newborns
#15
C Greco, I F Iskander, D M Akmal, S Z El Houchi, D A Khairy, G Bedogni, R P Wennberg, C Tiribelli, C D Coda Zabetta
OBJECTIVE: To compare the performance and accuracy of the JM-103 transcutaneous bilirubinometer and Bilistick System in measuring total serum bilirubin for the early identification of neonatal hyperbilirubinemia. STUDY DESIGN: The study was performed on 126 consecutive term and near-term (⩾36 weeks' gestational age) jaundiced newborns in Cairo University Children Hospital NICU, Egypt. Total serum bilirubin was assayed concurrently by the clinical laboratory and Bilistick System and estimated using the JM-103 transcutaneous bilirubin instrument...
June 15, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28587329/mosapride-combined-with-probiotics-on-gastrointestinal-function-and-growth-in-premature-infants
#16
Ai-Mei Zhang, Zhi-Qun Sun, Li-Ming Zhang
The aim of this study was to investigate the effects of mosapride combined with probiotics on gastrointestinal function and growth and development in premature infants. A total of 240 premature infants treated at Weifang People's Hospital between June 2012 and May 2015 who matched our criteria were randomly divided into three groups of 80 cases each. Group A received routine treatment, group B received routine treatment combined with live B. subtilis and E. faecium granules with multivitamins (Medilac-Vita), and group C received routine treatment and Saccharomyces boulardii sachets (Bioflor)...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28583873/a-trade-off-between-catalytic-activity-and-protein-stability-determines-the-clinical-manifestations-of-glucose-6-phosphate-dehydrogenase-g6pd-deficiency
#17
Usa Boonyuen, Kamonwan Chamchoy, Thitiluck Swangsri, Thanyaphorn Junkree, Nicholas P J Day, Nicholas J White, Mallika Imwong
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common polymorphism and enzymopathy in humans, affecting approximately 400 million people worldwide. It is responsible for various clinical manifestations, including favism, hemolytic anemia, chronic non-spherocytic hemolytic anemia, spontaneous abortion, and neonatal hyperbilirubinemia. Understanding the molecular mechanisms underlying the severity of G6PD deficiency is of great importance but that of many G6PD variants are still unknown. In this study, we report the construction, expression, purification, and biochemical characterization in terms of kinetic properties and stability of five clinical G6PD variants-G6PD Bangkok, G6PD Bangkok noi, G6PD Songklanagarind, G6PD Canton+Bangkok noi, and G6PD Union+Viangchan...
June 3, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28578174/maternal-marijuana-use-adverse-pregnancy-outcomes-and-neonatal-morbidity
#18
Torri D Metz, Amanda A Allshouse, Carol J Hogue, Robert L Goldenberg, Donald J Dudley, Michael W Varner, Deborah L Conway, George R Saade, Robert M Silver
BACKGROUND: The Eunice Kennedy Shriver National Institute of Child Health and Human Development Stillbirth Collaborative Research Network previously demonstrated an association between stillbirth and maternal marijuana use as defined by the presence of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid in the umbilical cord homogenate. However, the relationship between marijuana use and perinatal complications in live births is uncertain. OBJECTIVE: Our aim was to examine if maternal marijuana use is associated with increased odds of adverse pregnancy outcomes and neonatal morbidity among live-born controls in the Stillbirth Collaborative Research Network cohort...
May 31, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28576525/an-analysis-of-hearing-screening-test-results-in-2291-premature-infants-of-chinese-population
#19
Lili Huang, Fei Xiong, Jinrong Li, Fan Yang
OBJECTIVE: The aim of this study was to analyze the hearing screening program among preterm infants as well as to identify risk factors associated with failing primary newborn hearing screening. METHODS: The retrospectively selected population included all preterm infants who had primary hearing screening in a neonatal ward from January 1st, 2013 to December 31st, 2015 at West China Second University Hospital, Sichuan University. The newborn hearing screening (NHS) procedure was performed in all preterm infants by automated auditory brainstem response (AABR)...
April 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28571223/neonatal-hyperthyroidism-with-fulminant-liver-failure-a-case-report
#20
Mohammed Hasosah, Khalid Alsaleem, Mansour Qurashi, Abdullah Alzaben
Neonatal hyperthyroidism is a rare disease that is seen in infants born to mothers with Graves' disease. Hepatic manifestation of neonatal hyperthyroidism is extremely rare. We describe a neonate with fulminant liver failure secondary to neonatal hyperthyroidism caused by maternal Graves's disease. The baby was admitted with low birth weight and hepatosplenomegaly. At day 2 of life, the baby was irritable and he developed respiratory distress and fulminant hepatic failure which required mechanical ventilation...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
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