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Neonatal hyperbilirubinemia

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https://www.readbyqxmd.com/read/29295661/neonatal-hyperbilirubinemia-secondary-to-combined-anti-e-and-anti-c-isoimmunisation-a-literature-review
#1
Deepak Sharma, Nazanin Farahbakhsh
A term male infant was admitted at 48 hours of postnatal life to the neonatal unit for jaundice. The investigation showed total serum bilirubin (TSB) of 17.1 mg/dl, haemoglobin of 11 g/dl, reticulocyte count of 9.5% and peripheral smear was suggestive of macrocytic, normochromic red blood cell (RBC) with target cells and multiple spherocytes with occasional nucleated RBC. The infant's blood group was B positive. Direct antiglobulin test was strongly positive by gel method (3+). Mother's blood group was B positive and indirect antiglobulin test was positive when tested postnatally...
January 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29295636/caffeine-prevents-bilirubin-induced-cytotoxicity-in-cultured-newborn-rat-astrocytes
#2
Mehmet Deliktaş, Hacer Ergin, Aydın Demiray, Hakan Akça, Özmert M A Özdemir, Mehmet Bülent Özdemir
OBJECTIVE: Unconjugated bilirubin (UCB) may cause neurotoxicity in preterm neonates due to immaturity of UGT1A1 leading to bilirubin accumulation in the brain. Caffeine used in the treatment of apnea of prematurity was reported to decrease mechanical ventilation requirement, the frequencies of bronchopulmonary dysplasia, patent ductus arteriosus, cerebral palsy and neurodevelopmental disorders in very low birth weight infants. However, the effect of caffeine on hyperbilirubinemia was not yet clarified...
January 2, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29290974/sodium-taurocholate-cotransporting-polypeptide-ntcp-deficiency-identification-of-a-novel-slc10a1-mutation-in-two-unrelated-infants-presenting-with-neonatal-indirect-hyperbilirubinemia-and-remarkable-hypercholanemia
#3
Jian-Wu Qiu, Mei Deng, Ying Cheng, Raza-Muhammad Atif, Wei-Xia Lin, Li Guo, Hua Li, Yuan-Zong Song
Sodium taurocholate cotransporting polypeptide (NTCP) is encoded by the gene SLC10A1 and expressed in the basolateral membrane of the hepatocyte, functioning to uptake bile acids from plasma. Although SLC10A1 has been cloned and NTCP function studied intensively for years, clinical description of NTCP deficiency remains rather limited. This study reported the genotypic and phenotypic features of two neonatal patients with NTCP deficiency. They both presented with neonatal indirect hyperbilirubinemia and remarkable hypercholanemia, and harbored the SLC10A1 variants c...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29274316/comparative-evaluation-of-neonatal-bilirubin-using-radiometer-whole-blood-co-oximetry-and-plasma-bilirubin-methods-from-roche-diagnostics-and-ortho-clinical-diagnostics
#4
Ian Marie Lano, Andrew W Lyon, Li Wang, Rob Ruskin, Martha E Lyon
BACKGROUND: Clinically significant variation has been reported within and between plasma and whole blood total bilirubin methods used to identify neonates for whom clinical intervention for hyperbilirubinemia may be required. OBJECTIVE: To evaluate total bilirubin measurements between the Radiometer whole blood co-oximeter and plasma bilirubin methods from Roche Diagnostics and Ortho Clinical Diagnostics using neonatal specimens. METHODS: Total bilirubin levels were analyzed by whole blood co-oximetry (Radiometer® ABL90)...
December 20, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/29247156/melatonin-promotes-brain-derived-neurotrophic-factor-bdnf-expression-and-anti-apoptotic-effects-in-neonatal-hemolytic-hyperbilirubinemia-via-a-phospholipase-plc-mediated-mechanism
#5
Yong Luo, Mei Peng, Hong Wei
BACKGROUND Melatonin therapy shows positive effects on neuroprotective factor brain-derived neurotrophic factor (BDNF) expression and neuronal apoptosis in neonatal hemolytic hyperbilirubinemia. We hypothesized that melatonin promotes BDNF expression and anti-apoptotic effects in neonatal hemolytic hyperbilirubinemia through a phospholipase (PLC)-mediated mechanism. MATERIAL AND METHODS A phenylhydrazine hydrochloride (PHZ)-induced neonatal hemolytic hyperbilirubinemia model was constructed in neonatal rats...
December 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29208875/predicting-neonatal-hyperbilirubinemia-using-first-day-serum-bilirubin-level-in-late-preterm-and-term-healthy-newborn
#6
K A Khan, J Alam, N Nahar, S K Dey, M A Mannan, M Shahidullah
Hyperbilirubinemia is a common problem during the neonatal period and is the most common reason for readmission after early hospital discharge of the healthy near term and term infants. This early discharge policy along with limited follow-up facilities in developing countries and inadequate communication between physicians and parents necessitates a prognostic test to predict hyperbilirubinemia in these newborns; for early and effective management and prevention of potential complication before it occurred...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29203650/point-of-care-device-to-diagnose-and-monitor-neonatal-jaundice-in-low-resource-settings
#7
Pelham A Keahey, Mathieu L Simeral, Kristofer J Schroder, Meaghan M Bond, Prince J Mtenthaonnga, Robert H Miros, Queen Dube, Rebecca R Richards-Kortum
Newborns are at increased risk of jaundice, a condition in which excess bilirubin accumulates in blood. Left untreated, jaundice can lead to neurological impairment and death. Jaundice resulting from unconjugated hyperbilirubinemia is easily treated with exposure to blue light, and phototherapy systems have been developed for low-resource settings; however, there are no appropriate solutions to diagnose and monitor jaundice in these settings. To address this need we present BiliSpec, a low-cost reader and disposable lateral flow card designed to measure the concentration of total bilirubin from several drops of blood at the point of care...
December 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29191700/health-care-utilization-in-the-first-month-after-birth-and-its-relationship-to-newborn-weight-loss-and-method-of-feeding
#8
Valerie Flaherman, Eric W Schaefer, Michael W Kuzniewicz, Sherian Li, Eileen Walsh, Ian M Paul
OBJECTIVE: Guidelines recommend closer outpatient follow-up for exclusively breastfed newborns, especially those with pronounced weight loss, because of increased risk of hyperbilirubinemia and dehydration that might require readmission. Our objective was to determine how feeding method and weight loss are associated with neonatal healthcare utilization. DESIGN: Retrospective cohort study. SETTING: Northern California Kaiser Permanente hospitals in 2009-2013 PATIENTS: 143,889 neonates PREDICTORS: Inpatient method of feeding and inpatient and outpatient weights MAIN OUTCOME MEASURES: Inpatient and outpatient utilization in the 30 days after birth RESULTS: Newborn weight loss and feeding method were each associated with utilization...
November 27, 2017: Academic Pediatrics
https://www.readbyqxmd.com/read/29179591/effects-of-gly71arg-mutation-in-ugt1a1-gene-on-neonatal-hyperbilirubinemia-a-systematic-review-and-meta-analysis
#9
Hassan Mehrad-Majd, Monir Sadat Haerian, Javad Akhtari, Yalda Ravanshad, Anoush Azarfar, Gholamali Mamouri
OBJECTIVE: The associations between Gly71Arg polymorphism in the coding region of uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene and the risk of neonatal hyperbilirubinemia remained controversial. Therefore, a meta-analysis of observational studies has been conducted to assess the relationship between UGT1A1 gene polymorphisms of Gly71Arg and neonatal hyperbilirubinemia susceptibility. METHODS: An electronic literature search from online databases, such as PubMed, Embase, Cochrane and Scopus was conducted to identify eligible studies...
November 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29178522/direct-hyperbilirubinemia-in-infants-with-congenital-heart-disease
#10
Jun Fujishiro, Masahiko Sugiyama, Tetsuya Ishimaru, Miho Watanabe, Kaori Sato, Noriko Hoshino, Chizue Uotani, Mai Kutsukake, Yoichiro Hirata, Akira Oka
BACKGROUND: An association between congenital heart disease (CHD) and infantile cholestasis, a key finding for the diagnosis of biliary atresia (BA), remains unknown. The aim of this study was to investigate the characteristics of direct hyperbilirubinemia (D-HB) in infants with CHD. METHODS: All neonates who were admitted to our hospital and diagnosed with CHD in 2015 and 2016 were included. D-HB (direct bilirubin≧ 2.0 mg/dL) within 60 days of age and other clinical parameters were retrospectively reviewed...
November 27, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29150336/urinary-tract-infections-in-neonates-with-unexplained-pathological-indirect-hyperbilirubinemia-prevalence-and-significance
#11
Elif Bahat Ozdogan, Mehmet Mutlu, Secil Arslansoyu Camlar, Gülcin Bayramoglu, Sebnem Kader, Yakup Aslan
BACKGROUND: It is controversial to test for urinary tract infection (UTI) in patients with unexplained indirect hyperbilirubinemia in the first 2 weeks of life. We aimed to study the prevalence and significance of UTIs in such neonates who were requiring phototherapy. METHODS: Subjects were 2- to 14-day-old neonates with indirect bilirubin levels above phototherapy limit with no other abnormality in their bilirubinaemia-related etiologic workup. UTI was diagnosed by 2 consecutive positive cultures obtained by catheterisation, documenting growth of >10,000 colonies of the same microorganism with consistent antibiograms...
October 28, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29097178/delayed-versus-early-umbilical-cord-clamping-for-preterm-infants-a-systematic-review-and-meta-analysis
#12
Michael Fogarty, David A Osborn, Lisa Askie, Anna Lene Seidler, Kylie Hunter, Kei Lui, John Simes, William Tarnow-Mordi
OBJECTIVE: To compare the effects of delayed versus early cord clamping on hospital mortality (primary outcome) and morbidity in preterm infants using Cochrane Collaboration Neonatal Review Group methodology. DATA SOURCES: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials and Chinese articles, cross-referencing citations, expert informants and trial registries to 31 July 2017. STUDY ELIGIBILITY: RCTs of delayed (≥ 30 seconds) vs early (<30 seconds) clamping in infants born <37 weeks gestation...
October 30, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29095431/double-versus-single-intensive-phototherapy-with-leds-in-treatment-of-neonatal-hyperbilirubinemia
#13
M L Donneborg, P K Vandborg, B M Hansen, M Rodrigo-Domingo, F Ebbesen
OBJECTIVE: We investigate whether double phototherapy reduces total serum bilirubin concentration faster than single light during intensive phototherapy with high levels of irradiance using light-emitting diodes. STUDY DESIGN: Eighty-three infants with gestational age ⩾33 weeks and uncomplicated hyperbilirubinemia were randomized to either double (n=41) or single phototherapy (n=42) for 24 h. The mean irradiance was 64.8 μW cm-2 nm-1 from above and 39 μW cm-2 nm-1 from below...
November 2, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29079291/mechanisms-of-redox-interactions-of-bilirubin-with-copper-and-the-effects-of-penicillamine
#14
Bojana Božić, Jelena Korać, Dalibor M Stanković, Marina Stanić, Ana Popović-Bijelić, Jelena Bogdanović Pristov, Ivan Spasojević, Milica Bajčetić
Toxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or coordinate interactions with Cu(2+). However, the development and mechanisms of such interactions at physiological pH have not been resolved. This study shows that BR reduces Cu(2+) to Cu(1+) in 1:1 stoichiometry. Apparently, BR undergoes degradation, i.e. BR and Cu(2+) do not form stable complexes. The binding of Cu(2+) to inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions with BR...
October 26, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29067513/does-antenatal-steroids-treatment-prior-to-elective-cesarean-section-at-34-37%C3%A2-weeks-of-gestation-reduce-neonatal-morbidity-evidence-from-a-case-control-study
#15
Michal Kirshenbaum, Shali Mazaki-Tovi, Uri Amikam, Ram Mazkereth, Eyal Sivan, Eyal Schiff, Yoav Yinon
OBJECTIVE: To determine whether antenatal corticosteroids administration prior to an elective cesarean section (ECS) at 34-37 weeks gestation is associated with improved neonatal outcome. MATERIALS AND METHODS: A case control study of women with singleton pregnancies who underwent ECS between 34 and 37 weeks of gestation including two groups: (1) study group in which patients were treated with betamethasone prior to ECS (n = 58) and (2) control group matched for gestational age at delivery in which patients did not receive betamethasone (n = 107)...
January 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29067077/do-triple-test-results-predict-risk-for-neonatal-hyperbilirubinemia
#16
Hale Goksever Celik, Engin Celik, Gokhan Yildirim, Merih Cetinkaya
OBJECTIVE: Neonatal jaundice is the most common condition that requires hospital admission and outpatient follow-up after discharge in neonates. The values of more than 17 mg/dL in term infants are accepted as neonatal significant hyperbilirubinemia. We aimed to define if there is any relationship between second trimester serum markers and neonatal severe hyperbilirubinemia to protect the neonates from its neurological damage. METHODS: Total 1372 pregnant women were enrolled who had done triple test between April 2014 and 2015 and then given birth at our hospital...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29059457/systemic-regulation-of-bilirubin-homeostasis-potential-benefits-of-hyperbilirubinemia
#17
REVIEW
Ryoichi Fujiwara, Mathias Haag, Elke Schaeffeler, Anne T Nies, Ulrich M Zanger, Matthias Schwab
Neurotoxic bilirubin is the end product of heme catabolism in mammals. Bilirubin is solely conjugated by UDP-glucuronosyltransferase (UGT) 1A1, which is a membrane-bound enzyme that catalyzes a transfer of glucuronic acid. Due to low function of hepatic and intestinal UGT1A1 during the neonatal period, human neonates develop mild to severe physiological hyperbilirubinemia. The accumulation of bilirubin in the brain leads to the onset of irreversible brain damage, kernicterus. Breastfeeding is one of the most significant factors that increase the risk of developing kernicterus in infants...
October 23, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29058288/correlation-between-ugt1a1-polymorphism-and-neonatal-hyperbilirubinemia-of-neonates-in-wuhan
#18
Wei Liu, Li-Wen Chang, Min Xie, Wen-Bin Li, Zhi-Hui Rong, Li Wu, Ling Chen
This study attempts to discuss the correlation between UGT1A1*28 as uridine diphosphate glucuronosyltransferase gene promoter and coding region Gly71Arg gene polymorphism with neonatal hyperbilirubinemia of neonates in Wuhan. A total of 168 neonates were divided into the hyperbilirubinemia group (case group, n=108) and healthy neonates group (control group, n=60). Their DNA was obtained through blood extraction. The gene exon mutation of UGT1A1 was detected by Sanger sequencing, which revealed the relationship between UGT1A1*28 and Gly71Arg polymorphism with neonatal hyperbilirubinemia of neonates...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29016591/caesarean-section-during-second-stage-of-labor-in-a-tertiary-centre
#19
Padma Gurung, Sameer Malla, Sushma Lama, Anagha Malla, Alka Singh
BACKGROUND: There is an alarming rise in caesarean section leading to increased adverse outcomes for both the mother and fetus when compared with vaginal delivery. Within this increasing caesarean section rate, there is a concerning increase in the rate of second stage caesarean section. This study highlight the feto-maternal outcome of caesarean section in second stage of labour. METHODS: This was a retrospective cohort review of all women with a singleton, cephalic fetus at term delivered by caesarean section in the second stage of labor between April 1, 2013 and March 30, 2017 at Patan Academy of Health Sciences...
September 8, 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/29016584/morbidities-and-outcome-of-a-neonatal-intensive-care-in-western-nepal
#20
Sudhir Adhikari, Kalipatanam Seshagiri Rao, Ganesh B K, Namraj Bahadur
BACKGROUND: Neonatal mortality rate of developing countries is declining over decades. In the recent years increasing number of preterm and high risk neonates have facilities for tertiary care treatment. The aim of the study was to assess the morbidities and outcome of neonatal intensive care admissions. METHODS: It was a retrospective observational study carried out in neonatal intensive care unit of the Manipal Teaching Hospital, Pokhara, Nepal from January 2014 to December 2015...
September 8, 2017: Journal of Nepal Health Research Council
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