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https://www.readbyqxmd.com/read/28322864/water-soluble-derivatives-of-25-och3-ppd-and-their-anti-proliferative-activities
#1
Wu-Xi Zhou, Yuan-Yuan Sun, Wei-Hui Yuan, Yu-Qing Zhao
(20R)-25-Methoxyl-dammarane-3β,12β,20-triol (25-OCH3-PPD, AD-1) is a dammarane-type sapogenin showing anti-tumor potential. In the search for new anti-tumor agents with higher potency than our previously identified compound 25-OCH3-PPD, 11 novel sulfamic acid and diacid derivatives that could improve water solubility and contribute to good drug potency and pharmacokinetic profiles were designed and synthesized. Their in vitro anti-tumor activities in MCF-7, A-549, HCT-116, and BGC-823 cell lines and one normal cell line were tested by standard MTT assay...
March 18, 2017: Steroids
https://www.readbyqxmd.com/read/28281844/cxcr7-as-a-chemokine-receptor-for-sdf-1-promotes-gastric-cancer-progression-via-mapk-pathways
#2
Ameng Shi, Haitao Shi, Lei Dong, Shaoxian Xu, Miao Jia, Xiaoyan Guo, Ting Wang
OBJECTIVE: As the alternate receptor for stromal cell-derived factor-1 (SDF-1) except CXCR4, CXCR7 has been shown to be involved in the progression of some malignancies. However, the role of SDF-1/CXCR7 in gastric cancer (GC) remains unclear. MATERIALS AND METHODS: CXCR7 expression was examined in 83 human GC tissues and adjacent non-cancer tissues (ANCTs) by immunohistochemistry, in three human GC cell lines (MGC-803, BGC-823 and SGC-7901) by reverse transcription-PCR and western blot...
March 10, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28276770/synthesis-and-cytotoxic-activity-of-two-steroids-icogenin-aglycone-analogs
#3
Yu-Yao Guan, Shu-Zhen Li, Ping-Sheng Lei
During the process of icogenin analog research, we obtained two cytotoxic steroids: compound 4 and compound 6 casually. Their in vitro antitumor activities were tested by the standard MTT assay. The results disclosed that compound 4 (IC50 = 3.65-6.90 μM) showed potential antitumor activities against HELA, KB cell lines and compound 6 (IC50 = 2.40-9.05 μM) showed potential antitumor activities against HELA, BGC-823, KB, A549, HCT-8 cell lines.
September 22, 2016: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28264235/efficacy-of-balloon-guiding-catheter-for-mechanical-thrombectomy-in-patients-with-anterior-circulation-ischemic-stroke
#4
Jae-Sang Oh, Seok-Mann Yoon, Jai-Joon Shim, Jae-Won Doh, Hack-Gun Bae, Kyeong-Seok Lee
OBJECTIVE: To evaluate the efficacy of balloon guiding catheter (BGC) during thrombectomy in anterior circulation ischemic stroke. METHODS: Sixty-two patients with acute anterior circulation ischemic stroke were treated with thrombectomy using a Solitaire stent from 2011 to 2016. Patients were divided into the BGC group (n=24, 39%) and the non-BGC group (n=38, 61%). The number of retrievals, procedure time, thrombolysis in cerebral infarction (TICI) grade, presence of distal emboli, and clinical outcomes at 3 months were evaluated...
March 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28261170/the-global-regulators-lrp-leuo-and-hexa-control-secondary-metabolism-in-entomopathogenic-bacteria
#5
Yvonne Engel, Carina Windhorst, Xiaojun Lu, Heidi Goodrich-Blair, Helge B Bode
Photorhabdus luminescens TTO1 and Xenorhabdus nematophila HGB081 are insect pathogenic bacteria and producers of various structurally diverse bioactive natural products. In these entomopathogenic bacteria we investigated the role of the global regulators Lrp, LeuO, and HexA in the production of natural products. Lrp is a general activator of natural product biosynthesis in X. nematophila and for most compounds in TTO1. Microarray analysis confirmed these results in X. nematophila and enabled the identification of additional biosynthesis gene clusters (BGC) regulated by Lrp...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28259967/enhanced-expression-of-%C3%AE-2-3-linked-sialic-acids-promotes-gastric-cancer-cell-metastasis-and-correlates-with-poor-prognosis
#6
Li Shen, Zhiguo Luo, Junbo Wu, Li Qiu, Ming Luo, Qing Ke, Xiaoxia Dong
Gastric cancer (GC) is a highly metastatic disease and one of the leading causes of cancer death in the world. Aberrant glycosylation is one of many molecular changes that accompany malignant transformation. This study was aimed at identification of glycan profiling changes in GC progression and its potential mechanisms. We employed a microarray with 91 lectins to compare the differential glycans in the three human GC cell lines, SGC-7901, BGC-823 and MGC-803. According to glycan-binding specificities of lectins, all GC cell lines expressed common sugar structures, such as mannose, galactose and fucose...
February 20, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28255993/curcuminoid-ef24-enhances-the-anti-tumor-activity-of-akt-inhibitor-mk-2206-through-ros-mediated-er-stress-and-mitochondrial-dysfunction-in-gastric-cancer
#7
Xi Chen, Xuanxuan Dai, Peng Zou, Weiqian Chen, Vinothkumar Rajamanickam, Chen Feng, Weishan Zhuge, Chenyu Qiu, Qingqing Ye, Xiaohua Zhang, Guang Liang
BACKGROUND AND PURPOSE: Gastric cancer is one of the leading causes of morbidity and mortality worldwide. Akt is an anti-apoptotic kinase that plays a dynamic role in cell survival and is implicated gastric cancer pathogenesis. MK-2206, the first allosteric inhibitor of Akt, is in clinical trials for a number of cancers. Although preclinical studies have shown promise, clinical trials reported lack of response when given alone at tolerated doses. The aim of our study is to delineate the effects of MK-2206 in gastric cancer cells and explore combinatorial treatments to enhance the anti-tumor activity of MK-2206...
March 3, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28255248/microrna-320-inhibits-invasion-and-induces-apoptosis-by-targeting-crkl-and-inhibiting-erk-and-akt-signaling-in-gastric-cancer-cells
#8
Yue Zhao, Qianze Dong, Enhua Wang
MicroRNA-320 (miR-320) downregulation has been reported in several human cancers. Until now, its expression pattern and biological roles in human cancer remain unknown. This study aims to clarify its clinical expression pattern and biological function in gastric cancers. We found miR-320 level was downregulated in gastric cancer tissues. miR-320 mimic was transfected in SGC-7901 cells with low endogenous expression. miR-320 inhibitor was used in BGC-823 cells with high endogenous expression. We found that miR-320 inhibited SGC-7901 proliferation and invasion, with decreased expression of cyclin D1 and MMP9 at both mRNA and protein levels...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28251887/yeats-domain-containing-4-promotes-gastric-cancer-cell-proliferation-and-mediates-tumor-progression-via-activating-the-wnt-%C3%AE-catenin-signaling-pathway
#9
Sheqing Ji, Youxiang Zhang, Binhai Yang
Increased expression of YEATS domain containing 4 (YEATS4) has been reported to have correlation with the progression in lots of cancers. However, the mechanism on how it promotes the development of gastric cancer (GC) is rarely reported. This study aimed to investigate the effect of YEATS4 on cell proliferation and tumor progression. The mRNA and protein expressions of YEATS4 in GC tissues and cell lines were analyzed. Then BGC-823 cells were overexpressed or silenced YEATS4 by transfection of different plasmids...
March 2, 2017: Oncology Research
https://www.readbyqxmd.com/read/28251884/mir-101-3p-suppresses-hox-transcript-antisense-rna-hotair-induced-proliferation-and-invasion-through-directly-targeting-srf-in-gastric-carcinoma-cells
#10
Xiaoyu Wu, Jin Zhou, Zhenfeng Wu, Che Chen, Jiayun Liu, Guannan Wu, Jing Zhai, Fukun Liu, Gang Li
MiR-101-3p was identified as a tumor suppressor in several cancers, but its exact role in gastric adenocarcinoma is still largely unknown. In this study, we found that, compared with the RGM-1 human normal gastric epithelial cells, miR-101-3p was significantly downregulated in all the 6 human gastric adenocarcinoma cell lines, including BGC-823, MNK-45, MGC-803, SGC-7901, AGS and HGC-27. Overexpression miR-101-3p suppressed both the proliferation and invasion of AGS gastric adenocarcinoma cells and knockdown of miR-101-3p displayed an opposite effect...
March 2, 2017: Oncology Research
https://www.readbyqxmd.com/read/28239804/arsenic-trioxide-regulates-gastric-cancer-cell-apoptosis-by-mediating-camp
#11
A Abudoureyimu, A Muhemaitibake
OBJECTIVE: Gastric cancer is a common digestive tract tumor in clinic with increasing incidence. It is suggested that arsenic trioxide (As2O3) has an inhibitory effect on many kinds of digestive system tumors. This study evaluated the impact of As2O3 on the apoptosis of gastric cancer BGC-823 cells, and analyzed its relationship with cyclic adenosine monophosphate (cAMP). MATERIALS AND METHODS: Gastric cancer cell BGC-823 was intervened by different concentrations of As2O3 at 4 ng/ml, 8 ng/ml, and 16 ng/ml, respectively...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28236792/facile-fabrication-of-polyurethane-microcapsules-carriers-for-tracing-cellular-internalization-and-intracellular-ph-triggered-drug-release
#12
Yuqing Niu, Florian J Stadler, Jun Song, Siping Chen, Shiguo Chen
A tailor-made traceable pH-sensitive drug delivery system based on polyurethane (PU) microcapsules was fabricated using a facile double-emulsion method containing 3,3'-dioctadecyloxacarbocyanine perchlorate, doxorubicin (DOX) and sodium bicarbonate (NaHCO3). When PU microcapsules were immersed in acidic media, NaHCO3 could react with the H(+) to quickly produce CO2 bubbles to puncture the PU shell, resulting in rapid release of DOX to promptly reach the intracellular drug therapeutic threshold to kill cancer cells in a short period...
February 17, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28212338/synthesis-and-antitumor-activities-of-chiral-dipeptide-thioureas-containing-an-alpha-aminophosphonate-moiety
#13
Jingzi Liu, Peng Liao, Junfeng Hu, Hong Zhu, Yonglin Wang, Yongjun Li, Yan Li, Bin He
Thiourea derivatives demonstrate potent cytotoxic activity against various leukemias and many tumor cell lines. In our previous study, the combination of thiourea and phosphonate has been proven as an effective strategy for developing antitumor agents. Herein, we synthesized and evaluated a series of novel chiral dipeptide thioureas containing an α-aminophosphonate moiety as antitumor agents. Finally, we developed novel dipeptide thioureas 11d and 11f that showed comparable inhibition with that of Cisplatin against BGC-823 and A-549 cells, respectively...
February 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28211011/teoa-a-triterpenoid-from-actinidia-eriantha-induces-autophagy-in-sw620-cells-via-endoplasmic-reticulum-stress-and-ros-dependent-mitophagy
#14
Dandan Zhang, Cuixia Gao, Ruyi Li, Lin Zhang, Jingkui Tian
2α,3α,24-Thrihydroxyurs-12-en-28-oicacid (TEOA), a pentacyclic triterpenoid, isolated from the roots of Actinidia eriantha, exhibits significant cytotoxicity against SW620, BGC-823, HepG-2, A549 and PC-3 cancer cells. In this study, we investigated the underlying molecular mechanism of the anticancer activity of TEOA in SW620 cells. We demonstrated that TEOA induced apoptosis through cleavage of caspase-9 and PARP in SW620 cells. In addition, evidence of TEOA-mediated autophagy included the induction of autophagolysosomes and activation of autophagic markers LC-3B and p62...
February 16, 2017: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/28209093/two-new-cytotoxic-glycosides-isolated-from-the-green-walnut-husks-of-juglans-mandshurica-maxim
#15
Yuan-Yuan Zhou, Quan-Yu Liu, Bing-You Yang, Yan-Qiu Jiang, Yu-Xin Liu, Ying Wang, Shuang Guo, Haixue Kuang
Two new glycosides including an alcohol glycoside and a phenolic glycoside: hexyl-1-O-α-d-arabinofuranosyl-(1 → 6)-β-d-glucopyranoside (1), 4-hydroxypropiophenone-4-O-β-d-glucopyranosyl(1 → 6)-β-d-glucopyranoside(2), along with six known naphthalenyl glucosides (3-8) were isolated from green walnut husks of Juglans mandshurica, and their structures were elucidated on the basis of spectroscopic studies. All compounds were evaluated for their inhibitory effects on tumour cells (BGC-823, HepG-2, MCF-7)...
June 2017: Natural Product Research
https://www.readbyqxmd.com/read/28208606/ustiloxin-g-a-new-cyclopeptide-mycotoxin-from-rice-false-smut-balls
#16
Xiaohan Wang, Jian Wang, Daowan Lai, Weixuan Wang, Jungui Dai, Ligang Zhou, Yang Liu
Ustiloxins were cyclopeptide mycotoxins from rice false smut balls (FSBs) that formed in rice spikelets infected by the fungal pathogen Ustilaginoidea virens. To investigate the chemical diversity of these metabolites and their bioactivities, one new cyclopeptide, ustiloxin G (1), together with four known congeners-ustiloxins A (2), B (3), D (4), and F (5)-were isolated from water extract of rice FSBs. Their structures were elucidated by analyses of their physical and spectroscopic data, including ultraviolet spectrometry (UV), infrared spectroscopy (IR), 1D and 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization-mass spectrometry (HR-ESI-MS)...
February 10, 2017: Toxins
https://www.readbyqxmd.com/read/28197324/-125-i-f56-peptide-as-radioanalysis-agent-targeting-vegfr1-in-mice-xenografted-with-human-gastric-tumor
#17
Hua Zhu, Chuanke Zhao, Fei Liu, Lixin Wang, Junnan Feng, Chengchao Shou, Zhi Yang
(125)I-Radiolabeled F56 peptide was designed as a radioactive analogue of F56 (peptide WHSDMEWWYLLG) to bind with VEGFR1 receptor. It was synthesized in high radiochemical yield and specific activity. The in vitro stability of (125)I-F56 was tested, and the bioactivity of (125)I-F56 was confirmed by both cell uptake and binding affinity measurement in VEGFR1 positive BGC-823 cells. The time-radioactivity relationship and biodistribution of (125)I-F56 tracer were conducted using nude mice bearing human gastric carcinoma BGC-823, by noninvasive micro-SPECT/CT imaging...
February 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28196062/elemene-induces-apoptosis-of-human-gastric-cancer-cell-line-bgc-823-via-extracellular-signal-regulated-kinase-erk-1-2-signaling-pathway
#18
Pihong Li, Xiang Zhou, Weijian Sun, Weiwei Sheng, Yangyang Tu, Yaojun Yu, Jianda Dong, Bing Ye, Zhiqiang Zheng, Mingdong Lu
BACKGROUND Elemene is extracted from a traditional herbal medicine and is commonly used in the treatment of cancer in China. However, its effect on gastric cancer cells remains unknown. The goal of this study was to investigate its effect on human gastric cancer cells. MATERIAL AND METHODS Human gastric cancer BGC-823 cells and a tumor-bearing mouse model were employed to be divided into 4 groups: control group, elemene group, PD98059 group (an ERK 1/2 signaling pathway inhibitor), and the combined group (elemene plus PD98059)...
February 14, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28159956/microrna-495-inhibits-gastric-cancer-cell-migration-and-invasion-possibly-via-targeting-high-mobility-group-at-hook-2-hmga2
#19
Huashe Wang, Zhipeng Jiang, Honglei Chen, Xiaobin Wu, Jun Xiang, Junsheng Peng
BACKGROUND Gastric cancer is one of the most common malignancies, and has a high mortality rate. miR-495 acts as a suppressor in some cancers and HMGA2 (high mobility group AT-hook 2) is a facilitator for cell growth and epithelial-mesenchymal transition (EMT), but little is known about their effect in gastric cancer. This study aimed to investigate the role and mechanism of miR-495 in gastric cancer. MATERIAL AND METHODS miR-495 levels were quantitatively analyzed in gastric cancer tissue and GES-1, SGC-7901, BGC-823, and HGC-27 cell lines by qRT-PCR...
February 4, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28155603/advances-in-chemistry-and-pharmacology-of-triterpenoid-synthetic-dimers
#20
Barbara Bednarczyk-Cwynar, Andrzej Günther
The publication focuses on advances in chemistry and pharmacology of synthetic triterpenoid dimers, obtained from natural compounds. Synthetic triterpenoid dimers were divided into specific subgroups basing on the structure of main triterpenoid monomeric skeleton. Synthetic triterpenoid derivatives of dimeric structure can be obtained through the covalent linkage of the C-3 hydroxyl or another group, via the C-2 atom or the C-17 carboxyl group (mainly anhydrides, amides or esters). Some triterpenes can undergo chemical transformations leading to the formation of cyclic dimers or other types of dimers...
February 2, 2017: Current Medicinal Chemistry
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