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https://www.readbyqxmd.com/read/28506699/cra-crosolic-acid-isolated-from-actinidia-valvata-dunn-radix-induces-apoptosis-of-human-gastric-cancer-cell-line-bgc823-in%C3%A2-vitro-via-down-regulation-of-the-nf-%C3%AE%C2%BAb-pathway
#1
Qi-Lai Cheng, Hong-Liang Li, Ying-Chen Li, Zhao-Wen Liu, Xiao-Hua Guo, Yi-Jian Cheng
A natural ursolic compound, 2α,3β-dihydroxy-urs-12-en-28-oic acid (corosolic acid, CRA) was isolated from the root of Actinidia valvata Dunn. (A. valvata Radix). Since a large number of triterpenoid compound has marked anticancer effects toward various types of cancer cell lines in vitro, this study was carried out to investigate the anticancer effect of CRA in human gastric cancer cell line BGC823 cells and the underlying apoptotic mechanism of CRA was examined in BGC823 cell lines. The results showed that CRA significantly suppressed the viability of BGC823 cells in a concentration- and time-dependent manner...
May 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28506467/apoptosis-of-bovine-granulosa-cells-intracellular-pathways-and-differentiation
#2
M C Carou, P R Cruzans, A Maruri, M G Farina, C D Fiorito, G Olea, D M Lombardo
Follicular atresia in granulosa and theca cells occurs by apoptosis through weak hormonal stimulation. We have previously proposed an in vitro model to study this process by inducing apoptosis in BGC-1, a bovine granulosa cell line, and in primary cultures from ovaries with or without corpus luteum (CPGB+ and CPGB-, respectively), with different doses of gonadotropin releasing hormone (GnRH) analogs (leuprolide acetate (LA) as agonist and antide as antagonist). BGC-1 represent immature granulosa cells, whereas CPGB represent different degrees of luteinization...
May 12, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28498433/curcumin-induces-apoptotic-cell-death-and-protective-autophagy-in-human-gastric-cancer-cells
#3
Wei Li, Ying Zhou, Jin Yang, Haining Li, Huanhuan Zhang, Ping Zheng
Curcumin possesses an anticancer effect against a wide assortment of tumors with selective cytotoxicity for tumor cells. However, the mechanism involved in the curcumin‑induced anticancer effect remain unclear. In the present study, we investigated the efficacy of curcumin against human gastric cancer cell growth and the molecular mechanism involved. Our results demonstrated that curcumin inhibited the viabilities of gastric cancer cell lines BGC-823, SGC-7901 and MKN-28 in both a time- and dose-dependent manner...
May 11, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28485805/microrna-217-suppressed-epithelial-to-mesenchymal-transition-in-gastric-cancer-metastasis-through-targeting-ptpn14
#4
Y-P Liu, X-H Sun, X-L Cao, W-W Jiang, X-X Wang, Y-F Zhang, J-L Wang
OBJECTIVE: Gastric cancer (GC) is the third leading cause of cancer-related deaths while the mechanisms underlying its metastasis are not fully understood. In this study, we aimed to explore the relationship between miR-217 and GC metastasis. PATIENTS AND METHODS: We examined miR-217 level in gastric tumor tissues of 48 patients with GC and in cell lines including gastric mucosa epithelial cell line (GES-1), gastric cancer cell line (BGC-823), and gastric cancer cell line (SGC-7901)...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28476678/anticancer-efficacy-of-the-ethyl-acetate-extract-from-the-traditional-chinese-medicine-herb-celastrus-orbiculatus-against-human-gastric-cancer
#5
Haibo Wang, Lide Tao, Tengyang Ni, Hao Gu, Feng Jin, Xiaojun Dai, Jun Feng, Yanbing Ding, Weiming Xiao, Shiyu Guo, Tadashi Hisamitsu, Yayun Qian, Yanqing Liu
ETHNOPHARMACOLOGICAL RELEVANCE: The traditional Chinese medicine (TCM) herb Celastrus orbiculatus is an important folk medicinal plant in China that has been used as an anti-inflammatory, antitumor, and analgesic in various diseases. The ethyl acetate extract of C. orbiculatus (C. orbiculatus extract, COE) was reported to show significant antitumor effects. However, no study in China or abroad has reported the effect and mechanism of COE in triggering apoptosis of gastric cancer (GC) cells...
May 2, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28475004/knockdown-of-long-non-coding-rna-hoxd-as1-inhibits-gastric-cancer-cell-growth-via-inactivating-the-jak2-stat3-pathway
#6
Li Zheng, Jiangtao Chen, Zhongyong Zhou, Zhikuan He
Long non-coding RNA HOXD-AS1 (HOXD cluster antisense RNA 1) has been demonstrated to be closely associated with the progression of several tumors. However, the biological function of HOXD-AS1 and the underlying molecular mechanism in gastric cancer are still unclear. The expression of HOXD-AS1 in gastric cancer cell lines was evaluated by quantitative real-time polymerase chain reaction. The association of HOXD-AS1 expression and clinical parameters was statistically analyzed by chi-square test. Cell viability, colony formation capacity, and phosphorylation of Janus kinase 2 and signal transducer and activator of transcription 3 in treated SGC-7901 and BGC-823 cells were detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, colony formation assay, and western blot analysis, respectively...
May 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28472505/the-antibiotic-resistant-target-seeker-arts-an-exploration-engine-for-antibiotic-cluster-prioritization-and-novel-drug-target-discovery
#7
Mohammad Alanjary, Brent Kronmiller, Martina Adamek, Kai Blin, Tilmann Weber, Daniel Huson, Benjamin Philmus, Nadine Ziemert
With the rise of multi-drug resistant pathogens and the decline in number of potential new antibiotics in development there is a fervent need to reinvigorate the natural products discovery pipeline. Most antibiotics are derived from secondary metabolites produced by microorganisms and plants. To avoid suicide, an antibiotic producer harbors resistance genes often found within the same biosynthetic gene cluster (BGC) responsible for manufacturing the antibiotic. Existing mining tools are excellent at detecting BGCs or resistant genes in general, but provide little help in prioritizing and identifying gene clusters for compounds active against specific and novel targets...
May 2, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28463421/aromatic-polyketide-gtri-02-is-a-previously-unidentified-product-of-the-act-gene-cluster-in-streptomyces-coelicolor-a3-2
#8
Changsheng Wu, Koji Ichinose, Young Hae Choi, Gilles P van Wezel
The biosynthesis of aromatic polyketides derived from type II polyketide synthase (PKS) is complex, and it is not uncommon that highly similar gene clusters give rise to diverse structural architectures. The act biosynthetic gene cluster (BGC) of the model actinomycete Streptomyces coelicolor A3(2) is an archetypal type II PKS. Here, we show that the act BGC also specifies the aromatic polyketide GTRI-02 (1), and propose a mechanism for the biogenesis of its 3,4-dihydronaphthalen-1(2H)-one backbone. 1 was also produced by Streptomyces sp...
April 30, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28456034/synthesis-and-cytotoxicity-of-a-novel-series-of-saframycin-ecteinascidin-analogs-containing-tetrahydro-%C3%AE-carboline-moieties
#9
Xiangran Lu, Xuan Pan, Ying Yang, Ming Ji, Xiaoguang Chen, Zhiyan Xiao, Zhanzhu Liu
A novel bistetrahydrocarboline heptacyclic skeleton and its twenty derivatives were prepared from l-tryptophan through a 15-step stereospecific route. The cytotoxicities of these compounds were tested against six human cancer cell lines including HCT-116, HepG2, BGC-823, MCF-7, A2780, and HT-29. Most of the derivatives with amide side chain exhibited the IC50 values at the level of 10(-7) M, and a preliminary structure-activity relationship (SAR) was discussed. Both compound 30 with 2-pyridine amide side chain and compound 14 with phthalamide side chain showed the most potent and broad cytotoxicity towards all six cell lines with the IC50 values at the level of 10(-8) M...
April 24, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28447717/knockdown-of-zfpl1-results-in-increased-autophagy-and-autophagy%C3%A2-related-cell-death-in-nci%C3%A2-n87-and-bgc%C3%A2-823-human-gastric-carcinoma-cell-lines
#10
Yong-Zheng Xie, Wan-Li Ma, Ji-Ming Meng, Xue-Qun Ren
Macroautophagy, which will hereafter be referred to as autophagy, is an evolutionarily conserved process, during which cells recycle and remove damaged organelles and proteins in response to cellular stress. However, the mechanisms underlying the regulation of autophagy remain to be fully elucidated. The present study demonstrated that knockdown of zinc finger protein like 1 (ZFPL1) induces autophagy and increases autophagic cell death in NCI‑N87 and BGC‑823 human gastric carcinoma cell lines. To examine the role of ZFPL1 in gastric carcinoma cells, ZFPL1 expression was downregulated by lentiviral infection...
May 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28443463/decreased-expression-of-hsa_circ_0001895-in-human-gastric-cancer-and-its-clinical-significances
#11
Yongfu Shao, Linbo Chen, Rongdan Lu, Xinjun Zhang, Bingxiu Xiao, Guoliang Ye, Junming Guo
Circular RNAs are a special class of endogenous RNAs characterized by jointing 3' and 5' ends together via exon or intron circularization. Recent studies found that circular RNAs are involved in the development of some human diseases. However, little is known about their roles in human gastric cancer. In this study, we chose hsa_circ_0001895 as a targeted circRNA to investigate its clinical significances in gastric cancer patients. Hsa_circ_0001895 expression levels in five gastric cancer cell lines and 257 specimens of tissues were measured by real-time quantitative reverse transcription polymerase chain reaction...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28443111/subcellular-compartmentalization-and-chemical-forms-of-lead-participate-in-lead-tolerance-of-robinia-pseudoacacia-l-with-funneliformis-mosseae
#12
Li Huang, Haoqiang Zhang, Yingying Song, Yurong Yang, Hui Chen, Ming Tang
The effect of arbuscular mycorrhizal fungus on the subcellular compartmentalization and chemical forms of lead (Pb) in Pb tolerance plants was assessed in a pot experiment in greenhouse conditions. We measured root colonization, plant growth, photosynthesis, subcellular compartmentalization and chemical forms of Pb in black locust (Robinia pseudoacacia L.) seedlings inoculated with Funneliformis mosseae isolate (BGC XJ01A) under a range of Pb treatments (0, 90, 900, and 3000 mg Pb kg(-1) soil). The majority of Pb was retained in the roots of R...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28440026/mir-148b-inhibits-glycolysis-in-gastric-cancer-through-targeting-slc2a1
#13
Xiangfu Ding, Jingjing Liu, Tianzhou Liu, Zhiming Ma, Dacheng Wen, Jiaming Zhu
Although the molecular biology of GC has been well characterized, early diagnostic biomarkers and effective therapeutic options in gastric cancer are still under investigation. Here, we found that miR-148b expression decreased in human gastric cancer tissues compared with matched adjacent nontumor tissues by q-PCR analysis and in situ hybridization. Further investigation revealed that overexpression of miR-148b limited glycolysis including glucose consumption, lactate production in gastric cancer cell lines BGC-823 and MKN45...
April 24, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28439677/ap-2%C3%AE-reverses-vincristine-induced-multidrug-resistance-of-sgc7901-gastric-cancer-cells-by-inhibiting-the-notch-pathway
#14
Wei Lian, Li Zhang, Long Yang, Wensheng Chen
Multidrug resistance (MDR) remains a major clinical obstacle in the treatment of gastric cancer (GC) since it causes tumor recurrence and metastasis. The transcription factor activator protein-2α (AP-2α) has been implicated in drug-resistance in breast cancer; however, its effects on MDR of gastric cancer are far from understood. In this study, we aimed to explore the effects of AP-2α on the MDR in gastric cancer cells selected by vincristine (VCR). Decreased AP-2α levels were markedly detected by RT-PCR and Western blot in gastric cancer cell lines (BGC-823, SGC-7901, AGS, MKN-45) compared with that in the gastric epithelial cell line (GES-1)...
April 24, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28420180/synthesis-and-antiproliferative-activity-of-novel-all-trans-retinoic-acid-podophyllotoxin-conjugate-towards-human-gastric-cancer-cells
#15
Lei Zhang, Jing Wang, Lai Liu, Chengyue Zheng, Yang Wang
With the purpose of creating a multifunctional drug for gastric cancer treatment, a novel all-trans-retinoic acid (ATRA) conjugate with podophyllotoxin (PPT) was designed and synthesized, and its in vitro antiproliferative activity was evaluated against human gastric cancer cell lines using CCK-8 assay. The conjugate, P-A, exhibited significant anticancer activity against MKN-45 and BGC-823 cells with IC50 values of 0.419 ± 0.032 and 0.202 ± 0.055 μM, respectively. Moreover, P-A efficiently triggered cell cycle arrest and induced apoptosis in MKN-45 and BGC-823 cells due to modulation of cell cycle arrest- (CDK1, CDK2, CyclinA and CyclinB1) and apoptosis- (cleaved caspase-3, -8 and -9) related proteins, respectively...
April 17, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28394139/sequestration-of-guest-intermediates-by-dalesconol-bioassembly-lines-in-daldinia-eschscholzii
#16
Ai Hua Zhang, Wen Liu, Nan Jiang, Xin Lei Wang, Gang Wang, Qiang Xu, Ren Xiang Tan
Microbial constructions of secondary metabolites are generally biosynthetic gene cluster (BGC)-based, and the forging of different BGC-sourced intermediates tends to be overlooked. Here, we show that the dalesconol bioassembly lines in Daldinia eschscholzii can sequester guest intermediates (i.e., building blocks produced outside the dalesconol biosynthetic gene cluster) to form arrays of skeletally undescribed molecules such as (+)-dalescone A, a potent inhibitor against the NLRP3 inflammasome activation.
April 10, 2017: Organic Letters
https://www.readbyqxmd.com/read/28393452/minimization-of-the-thiolactomycin-biosynthetic-pathway-reveals-that-the-cytochrome-p450-enzyme-tlmf-is-required-for-five-membered-thiolactone-ring-formation
#17
Xiaoyu Tang, Jie Li, Bradley S Moore
Thiolactomycin (TLM) belongs to a class of rare and unique thiotetronate antibiotics that inhibit bacterial fatty acid synthesis. Although this group of natural product antibiotics was first discovered over 30 years ago, the study of TLM biosynthesis remains in its infancy. We recently discovered the biosynthetic gene cluster (BGC) for TLM from the marine bacterium Salinispora pacifica CNS-863. Here, we report the investigation of TLM biosynthetic logic through mutagenesis and comparative metabolic analyses...
April 10, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28391286/basal-ganglia-calcification-with-tetanic-seizure-suggest-mitochondrial-disorder
#18
Josef Finsterer, Barbara Enzelsberger, Adam Bastowansky
BACKGROUND Basal ganglia calcification (BGC) is a rare sporadic or hereditary central nervous system (CNS) abnormality, characterized by symmetric or asymmetric calcification of the basal ganglia. CASE REPORT We report the case of a 65-year-old Gypsy female who was admitted for a tetanic seizure, and who had a history of polyneuropathy, restless-leg syndrome, retinopathy, diabetes, hyperlipidemia, osteoporosis with consecutive hyperkyphosis, cervicalgia, lumbalgia, struma nodosa requiring thyroidectomy and consecutive hypothyroidism, adipositas, resection of a vocal chord polyp, arterial hypertension, coronary heart disease, atheromatosis of the aorta, peripheral artery disease, chronic obstructive pulmonary disease, steatosis hepatis, mild renal insufficiency, long-term hypocalcemia, hyperphosphatemia, impingement syndrome, spondylarthrosis of the lumbar spine, and hysterectomy...
April 9, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28388575/cofilin-1-induces-the-epithelial-mesenchymal-transition-of-gastric-cancer-cells-by-promoting-cytoskeletal-rearrangement
#19
Wang Haibo, Tao Lide, Jin Feng, Gu Hao, Dai Xiaojun, Ni Tengyang, Feng Jun, Ding Yanbing, Xiao Weiming, Qian Yayun, Liu Yanqing
Epithelial-mesenchymal transition (EMT) is an important biological process whereby malignant tumor cells obtain the ability to migrate, invade, resist apoptosis and degrade the extracellular matrix. We found that Cofilin1 (CFL1) expression was elevated in clinical gastric cancer specimens and correlated with biomarkers of EMT in BGC-823 gastric cancer cells. BGC-823 cells exhibited EMT phenotypes and increased metastatic ability when induced by TGF-β1. By contrast, BGC-823 cells transfected with Lv-siRNA-CFL1 did not exhibit EMT phenotypes under the same inducing conditions...
March 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28388537/ndv-d90-suppresses-growth-of-gastric-cancer-and-cancer-related-vascularization
#20
Hong Sui, Kaibing Wang, Rui Xie, Xi Li, Kunpeng Li, Yuxian Bai, Xishan Wang, Bin Bai, Dan Chen, Jiazhuang Li, Baozhong Shen
Recent reports suggest promises on using oncolytic Newcastle disease viruses (NDV) to treat different cancers, while the effects of a NDV-D90 strain on gastric cancer remain unknown. Here we showed that NDV-D90 induced gastric cancer cell apoptosis in a dose-dependent manner in 3 gastric cancer cell lines BGC-823, SGC-7901 and MKN-28. Pronounced reduction in cell invasion was detected in NDV-D90-treated BGC-823 and SGC-7901 cells, but not in MKN-28 cells. The increases in cell apoptosis and reduction in cell growth in NDV-D90-treated gastric cancer cells seemingly resulted from augmentation of p38 signaling and suppression of ERK1/2 and Akt signaling...
May 23, 2017: Oncotarget
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