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https://www.readbyqxmd.com/read/27917658/cytotoxic-coumaronochromones-from-the-inflorescences-of-celosia-cristata
#1
He Yan, Gonghai Zhang
Investigation on the MeOH extracts of the inflorescences of Celosia cristata led to the isolation of two new coumaronochromones, cristatone I (1) and cristatone II (2), along with three known flavones (3-5). Their structures were elucidated on the basis of spectroscopic analyses. Compounds 1-5 were tested for their cytotoxic activity against HeLa and BGC-823 cancer cell lines, of which cristatone II (2) showed interesting activity with the IC50 value of 23.82 μM.
December 5, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27904131/mir-31-regulates-rho-associated-kinase-myosin-light-chain-rock-mlc-pathway-and-inhibits-gastric-cancer-invasion-roles-of-rhoa
#2
Zhuo Chen, Shengnan Liu, Yuan Xia, Kejian Wu
BACKGROUND This study evaluated how the expression of miR-31 can be used to detect gastric cancer (GC) to help illuminate the role of miR-31 and RhoA in GC cells. MATERIAL AND METHODS We carried out our experiments using tissue specimens from 70 GC patients. The relative expression of miR-31 and RhoA mRNA in tissues and cells was detected by RT-PCR. The expression level of RhoA protein was detected by immunohistochemistry. GC cell line BGC-823 was transfected with six groups of vectors: blank group, NC (negative control) group, miR-31 mimics group, miR-31 mimics + RhoA group, miR-31 mimics + ROCK group, and miR-31 mimics + MLCK agonist group...
December 1, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27898345/quercetin-loading-cdse-zns-nanoparticles-as-efficient-antibacterial-and-anticancer-materials
#3
Xiaofang Yang, Weiwei Zhang, Zhiwei Zhao, Nuan Li, Zhipeng Mou, Dongdong Sun, Yongping Cai, Weiyun Wang, Yi Lin
Quercetin (Qe) plays an important role in inflammation, antibacterial, anticancer, and aging. However, Qe has extremely low water solubility, which is a major challenge in drug absorption. In this study, we described a simple method for synthesis of Qe/CdSe/ZnS nanoparticles (QCZ NPs). The QCZ NPs had an average diameter of 10nm and prominent yellow emission under UV irradiation. We investigated the antibacterial activity of QCZ NPs against drug-resistant Escherichia coli (E. coli) and Bacillus subtilis (B...
November 17, 2016: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/27875306/family-wide-structural-characterization-and-genomic-comparisons-decode-diversity-oriented-biosynthesis-of-thalassospiramides-by-marine-proteobacteria
#4
Weipeng Zhang, Liang Lu, Qiliang Lai, Beika Zhu, Zhongrui Li, Ying Xu, Zongze Shao, Karl Herrup, Bradley S Moore, Avena C Ross, Pei-Yuan Qian
The thalassospiramide lipopeptides have great potential for therapeutic applications, however, their structural and functional diversity, and biosynthesis are poorly understood. Here, by cultivating 130 Rhodospirillaceae strains sampled from oceans worldwide, we discovered 21 new thalassospiramide analogues and demonstrated their neuroprotective effects. To investigate the diversity of biosynthetic gene cluster (BGC) architectures, we sequenced the genomes of 28 Rhodospirillaceae strains. Our family-wide genomic analysis revealed three types of dysfunctional BGCs, and four functional BGCs whose architectures correspond to four production patterns...
November 14, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27871039/synthesis-and-antitumor-activity-of-novel-substituted-uracil-1-n-acetic-acid-ester-derivatives-of-20-s-camptothecins
#5
Di-Zao Li, Qiang-Zhe Zhang, Cun-Ying Wang, Yan-Ling Zhang, Xing-Yu Li, Ji-Tao Huang, Hong-Yan Liu, Zhao-Di Fu, Hua-Xian Song, Jin-Ping Lin, Teng-Fei Ji, Xian-Dao Pan
A series of novel substituted uracil-1'(N)-acetic acid esters (6-20) of camptothecins (CPTs) were synthesized by the acylation method. These new compounds were evaluated for in vitro antitumor activity against tumor cell lines, A549, Bel7402, BGC-823, HCT-8 and A2780. In vitro results showed that most of the derivatives exhibited comparable or superior cytotoxicity compare to CPT (1) and topotecan (TPT, 2), with 12 and 13 possessing the best efficacy. Four compounds, 9, 12, 13 and 16, were selected to be evaluated for in vivo antitumor activity against H22, BGC-823 and Bel-7402 in mice...
November 8, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27835600/yap1-enhances-cell-proliferation-migration-and-invasion-of-gastric-cancer-in-vitro-and-in-vivo
#6
Dan Sun, Xiaoting Li, Yingjian He, Wenhui Li, Ying Wang, Huan Wang, Shanshan Jiang, Yan Xin
Yes-associated protein 1 (YAP1) plays an important role in the development of carcinomas such as breast, colorectal, and gastric (GC) cancers, but the role of YAP1 in GC has not been investigated comprehensively. The present study strongly suggests that YAP1 and P62 were significantly up-regulated in GC specimens, compared with normal gastric mucosa. In addition, the YAP1high P62high expression was independently associated with poor prognosis in GC (hazard ratio: 1.334, 95% confidence interval: 1.045-1.704, P = 0...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27780355/the-development-of-visible-wavelength-maldi-cell-mass-spectrometry-cms-for-high-efficiency-single-cell-analysis
#7
Caiqiao Xiong, Xiaoyu Zhou, Qing He, Xi Huang, Jiyun Wang, Wen-Ping Peng, Huan-Cheng Chang, Zongxiu Nie
Mass is a fundamental physical property of individual cell, from which reveals the cell growth, cycle, and activity. Taking advantage of the cell mass spectrometry (CMS), accurate mass measurement of charged single cell has been achieved. However, with the increasing demand for high-efficiency single-cell analysis in biology, the limited throughput and inefficient cell desorption/ionization of the CMS inevitably becomes an important issue. To address the challenge, a state of the art visible-wavelength matrix assisted laser desorption/ionization (MALDI) CMS was developed...
October 26, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27769031/synthesis-sar-and-pharmacological-characterization-of-novel-anthraquinone-cation-compounds-as-potential-anticancer-agents
#8
Yanyan Zheng, Li Zhu, Lulu Fan, Wenna Zhao, Jianlong Wang, Xianxiao Hao, Yunhui Zhu, Xiufang Hu, Yaofeng Yuan, Jingwei Shao, Wenfeng Wang
Emodin, a natural anthraquinone derivative isolated from Rheum palmatum L., has been demonstrated to exhibit good anti-cancer effect. In this study, a series of novel quaternary ammonium salts of emodin, anthraquinone and anthrone were synthesized and their anticancer activities were tested in vitro. The effects of emodin quaternary ammonium salts on cell viability, apoptosis, intracellular ROS, and mitochondrial membrane potential were investigated in A375, BGC-823, HepG2 and HELF cells. The results demonstrated that compound 4a induced morphological changes and decreased cell viability...
October 7, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27764763/lifestyle-and-dna-base-composition-in-polychaetes
#9
Andrea Tarallo, Maria Cristina Gambi, Giuseppe D'Onofrio
A comparative analysis of polychaete species, classified as motile and low-motile forms, highlighted that the former were characterized not only by a higher metabolic rate (MR), but also by a higher genomic GC content. The fluctuation of both variables was not affected by the phylogenetic relationship of the species. Thus, present results further support that a very active lifestyle affects MR and GC at the same time, showing an unexpected similarity between invertebrates and vertebrates. In teleosts, indeed, a similar pattern has been also observed in comparisons of migratory and nonmigratory species...
December 1, 2016: Physiological Genomics
https://www.readbyqxmd.com/read/27755746/the-effects-of-climate-downscaling-technique-and-observational-data-set-on-modeled-ecological-responses
#10
Afshin Pourmokhtarian, Charles T Driscoll, John L Campbell, Katharine Hayhoe, Anne M K Stoner
Assessments of future climate change impacts on ecosystems typically rely on multiple climate model projections, but often utilize only one downscaling approach trained on one set of observations. Here, we explore the extent to which modeled biogeochemical responses to changing climate are affected by the selection of the climate downscaling method and training observations used at the montane landscape of the Hubbard Brook Experimental Forest, New Hampshire, USA. We evaluated three downscaling methods: the delta method (or the change factor method), monthly quantile mapping (Bias Correction-Spatial Disaggregation, or BCSD), and daily quantile regression (Asynchronous Regional Regression Model, or ARRM)...
July 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27716367/sdf-1-cxcr7-axis-regulates-the-proliferation-invasion-adhesion-and-angiogenesis-of-gastric-cancer-cells
#11
De-Min Ma, Dian-Xi Luo, Jie Zhang
BACKGROUND: More recent studies have revealed that chemokine receptor CXCR7 plays an important role in cancer development. However, little is known about the effect of CXCR7 on the process of gastric cancer cell invasion and angiogenesis. The aim of this study is to investigate the expression of CXCR7 in gastric cancer cell lines and to evaluate the role of CXCR7 in the proliferation, invasion, adhesion, and angiogenesis of gastric cancer cells. METHODS: Real-time PCR and Western blotting were used to examine the mRNA and protein levels of CXCR4 and CXCR7 in five gastric cancer cell lines (HGC-27, MGC-803, BGC-823, SGC-7901, and MKN-28)...
October 6, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27715057/structure-determinants-of-lagunamide-a-for-anticancer-activity-and-its-molecular-mechanism-of-mitochondrial-apoptosis
#12
Xiaoxing Huang, Wei Huang, Li Li, Xihuan Sun, Siyang Song, Qingyan Xu, Lianru Zhang, Bang-Guo Wei, Xianming Deng
Marine natural products are served as attractive source of anticancer therapeutics, with the great success of "first-in-class" drugs, such as Yondelis, Halaven, and Brentuximab vendotin. Lagunamides A-C from marine cyanobacterium, Lyngbya majuscula, exhibit exquisite growth inhibitory activities against cancer cells. In this study, we have systematically investigated the structure-activity relationships (SAR) of a concise collection of lagunamide A and its analogs constructed by total chemical synthesis against a broad panel of cancer cells derived from various tissues or organs, including A549, HeLa, U2OS, HepG2, BEL-7404, BGC-823, HCT116, MCR-7, HL-60, and A375...
October 7, 2016: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/27702451/sex-estimation-from-the-scapula-in-a-contemporary-chilean-population
#13
Tanya R Peckmann, Ciara Logar, Susan Meek
The scapula is valuable for sex estimation in human skeletons. Muscles provide protection to the scapula making it difficult to fracture, therefore increasing the potential for undamaged scapulae at forensic scenes. The goal of this project is to evaluate the accuracy of discriminant functions, created using an indigenous Guatemalan and contemporary Mexican population, when applied to a contemporary Chilean sample for estimation of sex from the scapula. The length of the glenoid cavity (LGC) and breadth of the glenoid cavity (BGC) were measured...
September 2016: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/27683755/remote-aspiration-thrombectomy-in-large-vessel-acute-ischemic-stroke
#14
Diogo C Haussen, Mehdi Bouslama, Jonathan A Grossberg, Raul G Nogueira
The use of balloon guide catheters in acute ischemic stroke intervention has been associated with improved reperfusion rates and clinical outcomes. This technique acts by promoting flow arrest and subsequent reversal to capture the thrombus debris that may be generated during the clot retrieval process. However, to the best of our knowledge, the use of BGC to remotely aspirate and remove intracranial thrombus has not been previously described. We report a three case series of patients with acute ischemic stroke from supraclinoidal internal carotid artery occlusions treated with remote aspiration thrombectomy through a BGC placed at the cervical internal carotid artery, leading to complete reperfusion without the need for intracranial catheterization...
September 28, 2016: Journal of Neurointerventional Surgery
https://www.readbyqxmd.com/read/27662451/basal-ganglia-calcification-in-psychiatric-inpatients-a-case-control-study
#15
Amir A Mufaddel, Ossama T Osman, Ghanem Al-Hassani, Shakhbout Al-Bedwawi, M Jawad Hashim
BACKGROUND AND OBJECTIVE: Several case reports have noted basal ganglia calcification (BGC) as an incidental radiologic finding in patients presenting with psychiatric manifestations. In this study, we examined the clinical correlates of mental disorders in two groups of psychiatric patients, one with BGC and one with normal radiologic studies. METHODS: In a retrospective cross-sectional case-control study of patients admitted to the psychiatric ward in Al Ain Hospital between January 2011 and December 2013, we compared all 15 patients diagnosed with BGC and 30 control patients who had normal radiologic findings...
September 2016: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
https://www.readbyqxmd.com/read/27632696/in-vitro-and-in-vivo-evaluation-of-redox-responsive-sorafenib-carrier-nanomicelles-synthesized-from-poly-acryic-acid-cystamine-hydrochloride-d-%C3%AE-tocopherol-succinate
#16
Yu Liu, Jia Yang, Xin Wang, Ju Liu, Zhaobo Wang, Hongsheng Liu, Lijiang Chen
In this study, a controlled drug release system based on redox-responsive nanomicelles for drug delivery was described. The system was constructed by linking poly (acryic acid) (PAA) with D-α-tocopherol succinate (VES) via a disulfide bond linker (ss). This amphiphilic polymer (PAAssVES) was synthesized by coupling reaction and its chemical structure was confirmed by FT-IR and (1)HNMR analyses. PAAssVES was found to self-assemble into nanomicelles with diameter of about 130 nm, and a critical micelle concentration of about 6...
December 2016: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/27612427/dctpp1-attenuates-the-sensitivity-of-human-gastric-cancer-cells-to-5-fluorouracil-by-up-regulating-mdr1-expression-epigenetically
#17
Li-Liang Xia, Ya-Bin Tang, Fei-Fei Song, Ling Xu, Ping Ji, Shu-Jun Wang, Ji-Min Zhu, Yong Zhang, Guo-Ping Zhao, Ying Wang, Tao-Tao Liu
Gastric cancer (GC) is among the most malignant cancers with high incidence and poor prognoses worldwide as well as in China. dCTP pyrophosphatase 1 (DCTPP1) is overexpressed in GC with a poor prognosis. Given chemotherapeutic drugs share similar structures with pyrimidine nucleotides, the role of DCTPP1 in affecting the drug sensitivity in GC remains unclear and is worthy of investigation. In the present study, we reported that DCTPP1-knockdown GC cell line BGC-823 exhibited more sensitivity to 5-fluorouracil (5-FU), demonstrated by the retardation of cell proliferation, the increase in cell apoptosis, cell cycle arrest at S phase and more DNA damages...
September 6, 2016: Oncotarget
https://www.readbyqxmd.com/read/27602110/famitinib-exerted-powerful-antitumor-activity-in-human-gastric-cancer-cells-and-xenografts
#18
Sai Ge, Qiyue Zhang, Qiong He, Jianling Zou, Xijuan Liu, Na Li, Tiantian Tian, Yan Zhu, Jing Gao, Lin Shen
Famitinib (SHR1020), a novel multi-targeted tyrosine kinase inhibitor, has antitumor activity against several solid tumors via targeting vascular endothelial growth factor receptor 2, c-Kit and platelet-derived growth factor receptor β. The present study investigated famitinib's activity against human gastric cancer cells in vitro and in vivo. Cell viability and apoptosis were measured, and cell cycle analysis was performed following famitinib treatment using 3-(4,5-dimethylthiazol -2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay, flow cytometry, terminal deoxynucleotidyl transferase dUTP nick end labeling assay and western blotting...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27599479/whole-genome-sequence-analysis-indicates-recent-diversification-of-mammal-associated-campylobacter-fetus-and-implicates-a-genetic-factor-associated-with-h2s-production
#19
Linda van der Graaf-van Bloois, Birgitta Duim, William G Miller, Ken J Forbes, Jaap A Wagenaar, Aldert Zomer
BACKGROUND: Campylobacter fetus (C. fetus) can cause disease in both humans and animals. C. fetus has been divided into three subspecies: C. fetus subsp. fetus (Cff), C. fetus subsp. venerealis (Cfv) and C. fetus subsp. testudinum (Cft). Subspecies identification of mammal-associated C. fetus strains is crucial in the control of Bovine Genital Campylobacteriosis (BGC), a syndrome associated with Cfv. The prescribed methods for subspecies identification of the Cff and Cfv isolates are: tolerance to 1 % glycine and H2S production...
2016: BMC Genomics
https://www.readbyqxmd.com/read/27596549/-methylation-and-demethylation-of-sox2-gene-promoter-in-bgc-823-gastric-cancer-cells
#20
B Wei, G Liu, H L Cai, G P Li, H Q Huang, Q Luo, Z J Huang
OBJECTIVE: To study the significance and effect of methylation status of sex determining region Y-box 2 (SOX2) gene promoter, and to investigate the effect of demethylation on the cell proliferation and invasion in BGC-823 gastric cancer cells. METHODS: Methylation-specific PCR (MSP) was used to assess the role of 5-aza-2'-deoxycytidine (5-Aza-CdR) in the methylation of SOX2 promoter in the BGC-823 cell lines treated with different concentration of 5-Aza-CdR. We mapped the expression of SOX2 in the BGC-823 cell lines by the quantitative real-time PCR (qPCR) and Western blotting before and after treatment of 5-Aza-CdR...
August 23, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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