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bariatric surgery and pcos

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https://www.readbyqxmd.com/read/29500679/bariatric-surgery-improves-hyperandrogenism-menstrual-irregularities-and-metabolic-dysfunction-among-women-with-polycystic-ovary-syndrome-pcos
#1
Jacob P Christ, Tommaso Falcone
OBJECTIVE: To characterize the impact of bariatric surgery on reproductive and metabolic features common to polycystic ovary syndrome (PCOS) and to assess the relevance of preoperative evaluations in predicting likelihood of benefit from surgery. METHODS: A retrospective chart review of records from 930 women who had undergone bariatric surgery at the Cleveland Clinic Foundation from 2009 to 2014 was completed. Cases of PCOS were identified from ICD coding and healthy women with pelvic ultrasound evaluations were identified using Healthcare Common Procedure Coding System coding...
March 2, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29481618/impact-of-diet-and-bariatric-surgery-on-anti-m%C3%A3-llerian-hormone-levels
#2
E Nilsson-Condori, J L Hedenbro, A Thurin-Kjellberg, A Giwercman, B Friberg
STUDY QUESTION: Do serum levels of anti-Müllerian hormone (AMH) change in women of reproductive age following dietary and surgery-induced weight loss? SUMMARY ANSWER: AMH levels increased after very low-calorie diet (VLCD) before surgery and decreased at 6 and 12 months after Roux-en-Y gastric bypass (RYGB), beyond expected normal age-related decline. WHAT IS KNOWN ALREADY: Obesity has negative effects on fertility and IVF outcomes, and possibly also on AMH levels...
February 22, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29344438/new-therapeutic-approaches-in-obesity-and-metabolic-syndrome-associated-with-polycystic-ovary-syndrome
#3
REVIEW
Fatima Saleem, Syed W Rizvi
Polycystic ovary syndrome (PCOS) is a pathophysiological disorder affecting reproductive and metabolic indices. PCOS is commonly associated with a high prevalence of insulin resistance and obesity; this association carries an increased risk of developing metabolic syndrome, type 2 diabetes mellitus (T2DM), and cardiovascular disease. Guidelines recommend lifestyle modification, metformin, hormonal contraceptives (HCs), and bariatric surgery as the main treatment options in obese patients with PCOS. Studies are being conducted to test the efficacy of existing treatment options as well as to discover new therapies...
November 13, 2017: Curēus
https://www.readbyqxmd.com/read/29042391/korean-obesity-surgical-treatment-study-kobess-protocol-of-a-prospective-multicentre-cohort-study-on-obese-patients-undergoing-laparoscopic-sleeve-gastrectomy-and-roux-en-y-gastric-bypass
#4
Young Suk Park, Do Joong Park, Joo Ho Lee, Hyuk-Joon Lee, Tae Kyung Ha, Yong-Jin Kim, Seung-Wan Ryu, Sang-Moon Han, Moon-Won Yoo, Sungsoo Park, Sang-Uk Han, Yoonseok Heo
INTRODUCTION: Bariatric surgery effectively induces long-term weight loss in Western populations. However, its effectiveness in Asians remains to be confirmed objectively. The Korean Society for Metabolic and Bariatric Surgery proposes the first prospective cohort study on Koreans undergoing bariatric surgery. METHODS AND ANALYSIS: The Korean OBEsity Surgical treatment Study (KOBESS) is a prospective, multicentre, single-arm, observational, cohort study on morbidly obese patients who undergo primary sleeve gastrectomy or Roux-en-Y gastric bypass in Korea...
October 16, 2017: BMJ Open
https://www.readbyqxmd.com/read/28486593/prevalence-of-obesity-associated-gonadal-dysfunction-in-severely-obese-men-and-women-and-its-resolution-after-bariatric-surgery-a-systematic-review-and-meta-analysis
#5
REVIEW
Hector F Escobar-Morreale, Elisa Santacruz, Manuel Luque-Ramírez, José I Botella Carretero
BACKGROUND: Sexual dimorphism manifests noticeably in obesity-associated gonadal dysfunction. In women, obesity is associated with androgen excess disorders, mostly the polycystic ovary syndrome (PCOS), whereas androgen deficiency is frequently present in obese men in what has been termed as male obesity-associated secondary hypogonadism (MOSH). Obesity-associated gonadal dysfunction, consisting of PCOS in women and MOSH in men, is a frequent finding in patients with severe obesity and it may be ameliorated or even resolve with marked weight loss, especially after bariatric surgery...
July 1, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28378209/bariatric-surgery-reduces-serum-anti-mullerian-hormone-levels-in-obese-women-with-and-without-polycystic-ovarian-syndrome
#6
Francesco Chiofalo, Cristina Ciuoli, Caterina Formichi, Federico Selmi, Raffaella Forleo, Ornella Neri, Giuseppe Vuolo, Patrizia Paffetti, Furio Pacini
PURPOSE: Obesity in fertile women has negative effect on fertility. Anti-mullerian hormone (AMH) represents a good index of fertility, and it is considered a marker of ovarian reserve and of polycystic ovarian syndrome (PCOS) gravity. Previous studies evaluated the relationship between obesity and AMH with contradictory results. The aim of the study was to investigate the relationship between obesity and AMH and the changes of AMH in obese women in reproductive age submitted to bariatric surgery...
July 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28292619/obesity-and-female-infertility-potential-mediators-of-obesity-s-impact
#7
REVIEW
Darcy E Broughton, Kelle H Moley
The worldwide upward trend in obesity has been dramatic, now affecting more than 20% of American women of reproductive age. Obesity is associated with many adverse maternal and fetal effects prenatally, but it also exerts a negative influence on female fertility. Obese women are more likely to have ovulatory dysfunction due to dysregulation of the hypothalamic-pituitary-ovarian axis. Women with polycystic ovarian syndrome who are also obese demonstrate a more severe metabolic and reproductive phenotype. Obese women have reduced fecundity even when eumenorrheic and demonstrate poorer outcomes with the use of in vitro fertilization...
April 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/27965894/bariatric-surgery-polycystic-ovary-syndrome-and-infertility
#8
REVIEW
James Butterworth, Jean Deguara, Cynthia-Michelle Borg
Background. Polycystic ovary syndrome (PCOS) is the commonest cause of female infertility. Visceral obesity and insulin resistance are key pathophysiological mechanisms behind PCOS. Women suffering from this syndrome and infertility often seek bariatric surgery hoping that they would be able to conceive postoperatively. Objective. At present, there is no consensus on the role of bariatric surgery in the management of PCOS-associated infertility within the medical community, making it difficult to give specific advice to these women, so a review of the literature was necessary...
2016: Journal of Obesity
https://www.readbyqxmd.com/read/27866938/ovulation-induction-in-polycystic-ovary-syndrome-current-options
#9
REVIEW
Richard S Legro
There are a variety of effective treatment options to induce ovulation in women with polycystic ovary syndrome (PCOS). The most effective treatments are primarily reproductive and target the hypothalamic-pituitary-ovarian (HPO) axis. Letrozole, an aromatase inhibitor, is headed toward replacing clomiphene, a selective estrogen receptor modulator, as the first-choice option. Metabolic treatments likely work indirectly through the HPO axis. Many metabolic treatments have shown initial promise and later failed (troglitozone or d-chiro-inositol) or disappointed (metformin); further studies are needed of newer agents to treat type 2 diabetes...
November 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27773356/polycystic-ovary-syndrome-and-endometrial-hyperplasia-an-overview-of-the-role-of-bariatric-surgery-in-female-fertility
#10
REVIEW
Vasileios Charalampakis, Abd A Tahrani, Ahmed Helmy, Janesh K Gupta, Rishi Singhal
One of the most effective methods to tackle obesity and its related comorbidities is bariatric surgery. Polycystic ovary syndrome (PCOS) and endometrial hyperplasia (EH), which are associated with increased risk of endometrial carcinoma, have been identified as potentially new indications for bariatric surgery. PCOS is the most common endocrine disorder in women in the reproductive age and is associated with several components of the metabolic syndrome such as obesity, insulin resistance and hypertension. EH is a pre-cancerous condition which arises in the presence of chronic exposure to estrogen unopposed by progesterone such as both in PCOS and obesity...
December 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27548360/ten-challenges-in-contraception
#11
REVIEW
Audrey Binette, Kerry Howatt, Ashley Waddington, Robert L Reid
Despite the introduction of promising products into the contraceptive market, the rate of unintended pregnancies remains high. Women with underlying medical conditions should have access to safe and effective contraceptive methods for various reasons, including the potential deleterious effect of the disease on the pregnancy or the effect of the pregnancy on the disease process. Healthcare providers are often confronted with cases in which contraception counseling is problematic due to controversial evidence and persistent myths...
January 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/27511809/the-management-of-anovulatory-infertility-in-women-with-polycystic-ovary-syndrome-an-analysis-of-the-evidence-to-support-the-development-of-global-who-guidance
#12
REVIEW
Adam H Balen, Lara C Morley, Marie Misso, Stephen Franks, Richard S Legro, Chandrika N Wijeyaratne, Elisabet Stener-Victorin, Bart C J M Fauser, Robert J Norman, Helena Teede
BACKGROUND: Here we describe the consensus guideline methodology, summarise the evidence-based recommendations we provided to the World Health Organisation (WHO) for their consideration in the development of global guidance and present a narrative review on the management of anovulatory infertility in women with polycystic ovary syndrome (PCOS). OBJECTIVE AND RATIONALE: The aim of this paper was to present an evidence base for the management of anovulatory PCOS...
November 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/27426125/gut-brain-axis-and-metabolism-in-polycystic-ovary-syndrome
#13
REVIEW
Basak Ozgen Saydam, Bulent O Yildiz
Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder, often accompanied and complicated by insulin resistance, glucose intolerance and obesity. Gut, brain and metabolism are highly related with each other in obesity and diabetes as well as in PCOS. Central nervous system regulates food intake through complex interactions of homeostatic and hedonic systems while gastrointestinal system contributes to food intake and metabolism via orexigenic and anorexigenic gastrointestinal hormones. Ghrelin is the only circulating orexigenic hormone whereas anorexigenic peptides include glucagon like peptide-1 (GLP-1), gastric inhibitory peptide (GIP), peptide YY (PYY) and cholecystokinin (CCK)...
2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27317009/bariatric-surgery-in-obese-women-of-reproductive-age-improves-conditions-that-underlie-fertility-and-pregnancy-outcomes-retrospective-cohort-study-of-uk-national-bariatric-surgery-registry-nbsr
#14
Eric Edison, Martin Whyte, Jeremy van Vlymen, Simon Jones, Piers Gatenby, Simon de Lusignan, Jill Shawe
BACKGROUND: The aims of this study are the following: to describe the female population of reproductive age having bariatric surgery in the UK, to assess the age and ethnicity of women accessing surgery, and to assess the effect of bariatric surgery on factors that underlie fertility and pregnancy outcomes. METHODS: Demographic details, comorbidities, and operative type of women aged 18-45 years were extracted from the National Bariatric Surgery Registry (NBSR)...
December 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27087540/effect-of-sleeve-gastrectomy-bariatric-surgery-induced-weight-loss-on-serum-amh-levels-in-reproductive-aged-women
#15
Shilpa Bhandari, Ishita Ganguly, Mohit Bhandari, Pallavi Agarwal, Aparna Singh, Nitika Gupta, Arun Mishra
OBJECTIVE: This study aims to evaluate the change in serum anti-Mullerian hormone (AMH) levels in patients with morbid obesity undergoing bariatric surgery for weight loss. MATERIAL AND METHODS: In this prospective observational study, 75 patients of reproductive age (20-35 years) undergoing bariatric surgery for morbid obesity were followed up after six months to determine the changes in weight, Body Mass Index (BMI), menstrual pattern and serum AMH. The results were further studied on basis of pre operative classification of patients in polycystic ovary syndrome (PCOS) and non-PCOS group...
October 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/26972165/metabolic-syndrome-diet-and-exercise
#16
REVIEW
Sunita M C De Sousa, Robert J Norman
Polycystic ovary syndrome (PCOS) is associated with a range of metabolic complications including insulin resistance (IR), obesity, dyslipidaemia, hypertension, obstructive sleep apnoea (OSA) and non-alcoholic fatty liver disease. These compound risks result in a high prevalence of metabolic syndrome and possibly increased cardiovascular (CV) disease. As the cardiometabolic risk of PCOS is shared amongst the different diagnostic systems, all women with PCOS should undergo metabolic surveillance though the precise approach differs between guidelines...
November 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/26520034/sleeve-gastrectomy-to-treat-concomitant-polycystyc-ovary-syndrome-insulin-and-leptin-resistance-in-a-27-years-morbidly-obese-woman-unresponsive-to-insulin-sensitizing-drugs-a-3-year-follow-up
#17
Luigi Schiavo, Giuseppe Scalera, Alfonso Barbarisi
INTRODUCTION: Insulin resistance (IR), leptin resistance (LR), and polycystic ovary syndrome (PCOS) commonly coexists with obesity. IR and PCOS are often successfully treated with the use of insulin-sensitizing drugs (ISDs). However, some women are poorly responsive or intolerant to them. If we additionally consider that currently no medical treatment for LR exists, it is crucial for the physician to find different therapeutic ways to treat patients with such multifactorial endocrinopathy...
2015: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/26431698/the-impact-of-bariatric-surgery-on-polycystic-ovary-syndrome-a-systematic-review-and-meta-analysis
#18
REVIEW
Daniel Skubleny, Noah J Switzer, Richdeep S Gill, Mark Dykstra, Xinzhe Shi, Margaret A Sagle, Christopher de Gara, Daniel W Birch, Shahzeer Karmali
Bariatric surgery has been proven to be a successful management strategy for morbid obesity, but limited studies exist on its effect on polycystic ovary syndrome (PCOS). A comprehensive search of electronic databases was completed. Meta-analysis was performed on PCOS, hirsutism, and menstrual irregularity outcomes following bariatric surgery. Thirteen primary studies involving a total of 2130 female patients were identified. The incidence of PCOS preoperatively was 45.6 %, which significantly decreased to 6...
January 2016: Obesity Surgery
https://www.readbyqxmd.com/read/25781065/novel-strategies-in-the-management-of-polycystic-ovary-syndrome
#19
REVIEW
P M Spritzer, A B Motta, T Sir-Petermann, E Diamanti-Kandarakis
Polycystic ovary syndrome (PCOS) is a common endocrinopathy affecting reproductive-aged women. PCOS has been recognized as a syndrome combining reproductive and metabolic abnormalities with lifelong health implications. Cardiometabolic alterations require regular screening and effective and targeted lifestyle advice to lose weight as well as to prevent weight gain. Pharmacological therapy includes insulin-sensitizer drugs and agents that act directly on metabolic comorbidities, such as statins and antiobesity drugs...
September 2015: Minerva Endocrinologica
https://www.readbyqxmd.com/read/25537661/effects-of-roux-en-y-gastric-bypass-surgery-on-eating-behaviour-and-allopregnanolone-levels-in-obese-women-with-polycystic-ovary-syndrome
#20
Sahruh Turkmen, Lotta Andreen, Yucel Cengiz
Polycystic ovary syndrome (PCOS) is associated with abnormal eating habits. We examined whether surgical treatment affected allopregnanolone levels and eating behaviour in nine women with PCOS who qualified for Rou-en-Y gastric bypass surgery. Blood samples were obtained to measure sex-hormone-binding globulin, total testosterone, progesterone, and allopregnanolone, and eating behaviour was evaluated using the Three-Factor Eating Questionnaire before surgery and at 6 and 12 months after surgery. Body mass index and total testosterone levels decreased, and progesterone and sex-hormone-binding globulin levels increased after bariatric surgery compared with pre-surgical values...
April 2015: Gynecological Endocrinology
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