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https://www.readbyqxmd.com/read/28229936/neurons-of-the-rat-cervical-spinal-cord-express-vimentin-and-neurofilament-after-intraparenchymal-injection-of-kainic-acid
#1
Fabián Nishida, María S Sisti, Carolina N Zanuzzi, Claudio G Barbeito, Enrique L Portiansky
Intermediate filaments (IF) can be altered under disorders such as neurodegenerative diseases. Kainic acid (KA) induce behavioral changes and histopathological alterations of the spinal cord of injected rats. Our goal was to evaluate the IF expression in neurons during this injury model. Animals were injected with KA at the C5 segment of the cervical spinal cord and euthanized at 1, 3 and 7 post injection (pi) days. Neuronal cell counting showed a significant loss of neurons at the injection site when compared with those of sham and non-operated animals...
February 14, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28223546/skip-lateral-lymph-node-metastasis-leaping-over-the-central-neck-compartment-in-papillary-thyroid-carcinoma
#2
Jianyong Lei, Jinjing Zhong, Ke Jiang, Zhihui Li, Rixiang Gong, Jingqiang Zhu
OBJECTIVE: This study was performed to investigate the frequency and pattern as well as the predictive factors of skip metastasis (lateral cervical lymph node metastasis without central lymph node metastasis) in papillary thyroid carcinoma (PTC). METHODS: 450 PTC patients who received total thyroidectomy with central neck dissection(CND) combined with modified radical lateral neck dissection(LND) were divided into two groups: with or without skip metastases. The clinicopathological characteristics were statistically compared and analyzed, and univariate and multivariate analyses were performed to detect the risk factors of skip metastasis...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28216915/a-rare-and-interesting-case-of-heterotopic-cervical-pregnancy-after-intracytoplasmic-sperm-injection-and-embryo-transfer
#3
Ritu Punhani, Kundavi Shankar, Thankam R Varma
The wide use of assisted reproductive technologies has contributed to the increased risk of ectopic and subsequently heterotopic pregnancy (HP) rate. Cervical ectopic pregnancy is a very rare and life-threatening form of ectopic pregnancy that can also present as HP. We are describing here a case of 34-year-old woman who presented with bleeding heterotopic cervical pregnancy (HCP). The concomitant viable cervical and intrauterine pregnancies were diagnosed at 8 weeks of gestation. Selective fetal reduction was done for cervical pregnancy following which uterine artery embolization was done as a life-saving measure, and subsequently, injection methotrexate was also given...
October 2016: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28216674/ccr7-deficient-inflammatory-dendritic-cells-are-retained-in-the-central-nervous-system
#4
Benjamin D Clarkson, Alec Walker, Melissa G Harris, Aditya Rayasam, Martin Hsu, Matyas Sandor, Zsuzsanna Fabry
Dendritic cells (DC) accumulate in the CNS during neuroinflammation, yet, how these cells contribute to CNS antigen drainage is still unknown. We have previously shown that after intracerebral injection, antigen-loaded bone marrow DC migrate to deep cervical lymph nodes where they prime antigen-specific T cells and exacerbate experimental autoimmune encephalomyelitis (EAE) in mice. Here, we report that DC migration from brain parenchyma is dependent upon the chemokine receptor CCR7. During EAE, both wild type and CCR7-/- CD11c-eYFP cells infiltrated into the CNS but cells that lacked CCR7 were retained in brain and spinal cord while wild type DC migrated to cervical lymph nodes...
February 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28212662/marked-central-nervous-system-pathology-in-cd59-knockout-rats-following-passive-transfer-of-neuromyelitis-optica-immunoglobulin-g
#5
Xiaoming Yao, Alan S Verkman
Neuromyelitis optica spectrum disorders (herein called NMO) is an inflammatory demyelinating disease of the central nervous system in which pathogenesis involves complement-dependent cytotoxicity (CDC) produced by immunoglobulin G autoantibodies targeting aquaporin-4 (AQP4-IgG) on astrocytes. We reported evidence previously, using CD59(-/-) mice, that the membrane-associated complement inhibitor CD59 modulates CDC in NMO (Zhang and Verkman, J. Autoimmun. 53:67-77, 2014). Motivated by the observation that rats, unlike mice, have human-like complement activity, here we generated CD59(-/-) rats to investigate the role of CD59 in NMO and to create NMO pathology by passive transfer of AQP4-IgG under conditions in which minimal pathology is produced in normal rats...
February 17, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28203184/spinal-cord-infarction-after-cervical-transforaminal-epidural-steroid-injection-case-report-and-literature-review
#6
Jangsup Moon, Hyung-Min Kwon
INTRODUCTION: Transforaminal epidural steroid injection (TFESI) is a widely used nonsurgical procedure in the treatment of patients with radiculopathy. It is efficacious in relieving pain, but a number of complications are being reported. Recently, increasing frequency of major complications, such as spinal cord infarction and cerebral infarction, has been reported with the use of a particulate steroid within fluoroscopic-guided procedures. METHODS: We report a 49-year-old man with a history of chronic cervical radiculopathy, who experienced a devastating complication after TFESI...
January 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/28196672/a-study-on-uterine-lymphatic-anatomy-for-standardization-of-pelvic-sentinel-lymph-node-detection-in-endometrial-cancer
#7
Barbara Geppert, Céline Lönnerfors, Michele Bollino, Anastasija Arechvo, Jan Persson
OBJECTIVE: To describe the anatomy of uterine lymphatic drainage following cervical or fundal tracer injection to enable standardization of a pelvic sentinel lymph node (SLN) concept in endometrial cancer (EC). METHODS: A prospective consecutive study of women with EC was conducted. A fluorescent dye (Indocyanine green) was injected into the cervix (n=60) or the uterine fundus (n=30). A systematic trans- and retroperitoneal mapping of uterine lymphatic drainage was performed...
February 10, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28166961/optimization-of-post-cervical-artificial-insemination-in-gilts-effect-of-cervical-relaxation-procedures-and-catheter-type
#8
Iván Hernández-Caravaca, Pedro J Llamas-López, M José Izquierdo-Rico, Cristina Soriano-Úbeda, Carmen Matás, Juan C Gardón, Francisco A García-Vázquez
Post-cervical (pC) artificial insemination (AI) has been successfully developed for application in multiparous sows, although it has proved problematic in gilts. This study analyzes the use of pC-AI in gilts by two experiments. In the first experiment, the efficiency of pC-AI in gilts was evaluated using a multi-ring multiparous catheter (MpC), which led to 23.1% of the gilts being successfully inseminated. In gilts where insemination was not possible using an MpC, two alternatives were applied before a second attempt at insemination: 1) Vetrabutin Chlorhydrate (VC) was intramuscularly injected in order to relax the cervix; or 2) Warm extender (WE) was deposited in the cervix to modify the cervical muscle dynamics...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28166955/long-term-prostaglandin-based-protocols-improve-the-reproductive-performance-after-timed-artificial-insemination-in-sheep
#9
S Fierro, C Viñoles, J Olivera-Muzante
The aim of the experiment was to evaluate the reproductive performance of ewes synchronized with two doses of prostaglandin F2α (PG) at different intervals and inseminated at a fixed time. During the breeding season (April to June), 370 multiparous Corriedale ewes were assigned to five groups according to body condition score and body weight, and synchronized with two doses of PG administered 7, 10, 12, 14 or 16 days apart (groups PG7, PG10, PG12, PG14 or PG16; n = 73, 76, 74, 72, 75; respectively). Cervical timed artificial insemination (Day 0) was performed at 48 ± 1...
March 1, 2017: Theriogenology
https://www.readbyqxmd.com/read/28159465/a-comparison-of-sentinel-lymph-node-biopsy-to-lymphadenectomy-for-endometrial-cancer-staging-fires-trial-a-multicentre-prospective-cohort-study
#10
Emma C Rossi, Lynn D Kowalski, Jennifer Scalici, Leigh Cantrell, Kevin Schuler, Rabbie K Hanna, Michael Method, Melissa Ade, Anastasia Ivanova, John F Boggess
BACKGROUND: Sentinel-lymph-node mapping has been advocated as an alternative staging technique for endometrial cancer. The aim of this study was to measure the sensitivity and negative predictive value of sentinel-lymph-node mapping compared with the gold standard of complete lymphadenectomy in detecting metastatic disease for endometrial cancer. METHODS: In the FIRES multicentre, prospective, cohort study patients with clinical stage 1 endometrial cancer of all histologies and grades undergoing robotic staging were eligible for study inclusion...
January 31, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28157825/pain-sensation-during-colposcopy-and-cervical-biopsy-with-or-without-local-anesthesia-a-randomized-trial
#11
Mari Kiviharju, Ilkka Kalliala, Pekka Nieminen, Tadeusz Dyba, Annika Riska, Maija Jakobsson
OBJECTIVE: The aim of the study was to determine whether an injection of a local anesthetic is more painful than a cervical punch biopsy without local anesthesia. MATERIALS AND METHODS: The study was a randomized controlled trial, conducted at the Helsinki University Central Hospital. It consisted of 204 women referred for colposcopic assessments. Half of them were randomized to receive local anesthesia before their cervical punch biopsies. After the injection of the local anesthetic, the cervical punch biopsy, and the endocervical curettage, the women scored their actual pain using a 10-cm visual analog scale (VAS)...
February 3, 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28155582/image-derived-input-function-estimation-on-a-tof-enabled-pet-mr-for-cerebral-blood-flow-mapping
#12
Mohammad Mehdi Khalighi, Timothy W Deller, Audrey Peiwen Fan, Praveen K Gulaka, Bin Shen, Prachi Singh, Jun-Hyung Park, Frederick T Chin, Greg Zaharchuk
(15)O-H2O PET imaging is an accurate method to measure cerebral blood flow (CBF) but it requires an arterial input function (AIF). Historically, image-derived AIF estimation suffers from low temporal resolution, spill-in, and spill-over problems. Here, we optimized tracer dose on a time-of-flight PET/MR according to the acquisition-specific noise-equivalent count rate curve. An optimized dose of 850 MBq of (15)O-H2O was determined, which allowed sufficient counts to reconstruct a short time-frame PET angiogram (PETA) during the arterial phase...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28154344/importance-of-recognizing-carpal-tunnel-syndrome-for-neurosurgeons-a-review
#13
Masatoshi Yunoki, Takahiro Kanda, Kenta Suzuki, Atsuhito Uneda, Koji Hirashita, Kimihiro Yoshino
Idiopathic carpal tunnel syndrome (CTS) is a common complaint, reflecting entrapment neuropathy of the upper extremity. CTS produces symptoms similar to those of other conditions, such as cervical spondylosis or ischemic or neoplastic intracranial disease. Because of these overlaps, patients with CTS are often referred to a neurosurgeon. Surgical treatment of CTS was started recently in our department. Through this experience, we realized that neurosurgeons should have an increased awareness of this condition so they can knowledgeably assess patients with a differential diagnosis that includes CTS and cervical spinal and cerebral disease...
February 2, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28151550/canine-acute-cervical-myelopathy-hydrated-nucleus-pulposus-extrusion-or-intraspinal-discal-cysts
#14
Cristian Falzone
OBJECTIVE: To differentiate between hydrated nucleus pulposus extrusion and ventral intraspinal discal cysts in dogs. STUDY DESIGN: Prospective case series. ANIMALS: Twenty dogs with acute onset of cervical myelopathy due to hydrated nucleus pulposus extrusion or ventral intraspinal discal cysts. METHODS: Clinical and magnetic resonance (MR) imaging findings, outcome after surgical treatment, cytologic and histologic findings of compressive material were taken into account...
February 2, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28143552/abscess-of-the-cervical-spine-secondary-to-injection-site-infection-in-a-heifer
#15
Ueli Braun, Christian Gerspach, Karolin Kühn, Julia Bünter, Monika Hilbe
BACKGROUND: Abscesses in the neck region can result from infection associated with injection of drugs into the neck muscles. To our knowledge, there have been no reports of osteomyelitis of the cervical vertebra and spinal cord compression secondary to an abscess in the neck. This case report describes the findings in a 9.5-month-old heifer with an abscess of the cervical spine secondary to injection site infection. CASE PRESENTATION: The main clinical findings were swelling on the left side of the neck, proprioceptive deficits in all limbs and generalised ataxia...
January 31, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/28138727/preoperative-localization-of-mediastinal-parathyroid-adenoma-with-intra-arterial-methylene-blue
#16
Rida Salman, Mikhael G Sebaaly, Mohammad Rachad Wehbe, Pierre Sfeir, Mohamad Khalife, Aghiad Al-Kutoubi
Ectopic parathyroid is found in 16% of patients with hyperparathyroidism. 2% of ectopic parathyroid adenomas are not accessible to standard cervical excision. In such cases, video-assisted thoracoscopic resection is the recommended definitive treatment. We present a case of mediastinal parathyroid adenoma localized preoperatively by injecting methylene blue within a branch of the internal mammary artery that is supplying the adenoma. Intra-arterial methylene blue injection facilitated visualization and resection of the adenoma...
January 30, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28138245/quality-of-life-in-cervical-dystonia-after-treatment-with-botulinum-toxin-a-a-24-week-prospective-study
#17
Subsai Kongsaengdao, Benchalak Maneeton, Narong Maneeton
OBJECTIVE: This study aimed to identify possible improvements in disease-specific health-related quality of life (HRQoL) after multiple injections of botulinum toxin A over 24 weeks in Thai cervical dystonia (CD) patients. MATERIALS AND METHODS: A 24-week prospective study comparing HRQoL of Thai CD patients before and after multiple injections of botulinum toxin A at 3-month intervals was performed. Disease-specific HRQoL was assessed by using the Cervical Dystonia Impact Profile-58 questionnaire (CDIP-58) and the Craniocervical Dystonia Questionnaire-24 (CDQ-24)...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28135123/prefabricated-cervical-skin-flaps-for-hemi-facial-resurfacing-elucidating-the-natural-history-of-postoperative-edema-using-indocyanine-green
#18
Ke Li, Peiru Min, Parviz Sadigh, Luca Grassetti, Davide Lazzeri, Matteo Torresetti, Riccardo Marsili, Shaoqing Feng, Ningfei Liu, Yi Xin Zhang
BACKGROUND: The increases in capillary wall permeability and capillary hydrostatic pressure are considered to be the causes for the acute swelling seen in flaps; however, disruption of the circulating flap lymphatics could be another contributory factor. In this study we monitor the development of flap edema in a series of 18 prefabricated flaps and aim to delineate the natural history of this phenomenon by use of lymphography. METHODS: Postoperative swelling was monitored in a series of 18 pre-expanded prefabricated cervical skin flaps used for hemi-facial burns-scar resurfacing...
January 30, 2017: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/28121632/ultrasound-guided-injection-to-the-fifth-cervical-spinal-nerve-root-level
#19
Carl P C Chen, Pei-Chi Huang, Henry L Lew, Chia-Wei Yu
No abstract text is available yet for this article.
January 24, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28112371/microrna-145-inhibits-tumorigenesis-and-invasion-of-cervical-cancer-stem-cells
#20
Xi Zhou, Yan Yue, Renxiao Wang, Baolan Gong, Zhao Duan
MicroRNA (miR)-145 has been reported to induce cancer stem cell (CSC) differentiation through down-regulation of the stem cell transcription factors (TFs) that maintain CSC pluripotency. High expression of miR-145 indicates a good prognosis in cancer patients, but its role in cervical cancer stem cells (CCSCs) is not known. We show that expression of miR-145 and core stem cell transcription factors, Sox2, Nanog and Oct4, are associated with the pluripotency of CCSCs, with increased expression of miR-145 after cervical tumorsphere (CT) differentiation...
March 2017: International Journal of Oncology
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