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Cervical injection

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https://www.readbyqxmd.com/read/28528478/the-diagnosis-and-management-of-a-vertebral-artery-loop-causing-cervical-radiculopathy
#1
L Wood, M Czyz, S Forster, Bronek M Boszczyk
BACKGROUND: Cervical radiculopathies are rarely caused by vertebral artery loop formation, which is estimated to be present in less than 3% of patients. It is uncertain what causes the loop formation: some propose an association with spondylotic changes or trauma, whilst others suggest hypertension and atherosclerosis may be responsible. CASE REPORT 1: A 35-year-old male patient presented with signs and symptoms of cervical radiculopathy that was not improved with anterior cervical discectomy and fusion surgery performed 2 years beforehand...
May 20, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28525647/evaluation-of-the-effects-of-tanezumab-a-monoclonal-antibody-against-nerve-growth-factor-on-the-sympathetic-nervous-system-in-adult-cynomolgus-monkeys-macaca-fascicularis-a-stereologic-histomorphologic-and-cardiofunctional-assessment
#2
Patrice Belanger, Paul Butler, Mark Butt, Siddhartha Bhatt, Stephen Foote, David Shelton, Mark Evans, Rosalinda Arends, Susan Hurst, Carlin Okerberg, Thomas Cummings, David Potter, Jill Steidl-Nichols, Mark Zorbas
Tanezumab, a humanized monoclonal antibody against nerve growth factor is in development for treatment of chronic pain. Three nonclinical studies assessed effects of clinically relevant and supratherapeutic doses of tanezumab on the sympathetic nervous system (SNS) of adult nonhuman primates. Study 1 evaluated potential effects of subcutaneous (SC) tanezumab (1.2 mg/kg every 8 weeks [Q8W]) on SNS in cynomolgus monkeys for 3 or 6 months and reversibility or persistence of any effects through a non-dosing/recovery period...
May 19, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28518122/dorsal-root-ganglion-injection-and-dorsal-root-crush-injury-as-a-model-for-sensory-axon-regeneration
#3
Menghon Cheah, James W Fawcett, Melissa R Andrews
Achieving axon regeneration after nervous system injury is a challenging task. As different parts of the central nervous system (CNS) differ from each other anatomically, it is important to identify an appropriate model to use for the study of axon regeneration. By using a suitable model, we can formulate a specific treatment based on the severity of injury, the neuronal cell type of interest, and the desired spinal tract for assessing regeneration. Within the sensory pathway, DRG neurons are responsible for relaying sensory information from the periphery to the CNS...
May 3, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28510138/antitumor-efficacy-of-auger-electron-emitter-111-in-delivered-by-modular-nanotransporter-into-the-nuclei-of-cells-with-folate-receptor-overexpression
#4
A A Rosenkranz, T A Slastnikova, Yu V Khramtsov, T S Karyagina, G P Georgiev, A S Sobolev
A new modular nanotransporter (MNT) for the delivery of anticancer agents into the nuclei of cells with folate receptor overexpression was created. An effective method for acceding labeling of this MNT with Auger electron emitter (111)In has been developed. A significant therapeutic effect was observed after a single intratumoral injection of the new (111)In-labeled MNT to mice grafted with human cervical carcinoma characterized by folate receptor overexpression.
March 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28508693/a-metabolite-profiling-method-for-diagnosis-of-precancerous-cervical-lesions-and-hpv-persistence
#5
Heather Walker, Michael Burrell, Janet Flatley, Hilary Powers
AIM: With the advent of rapid metabolic profiling techniques and of portable mass spectrometers we examined whether cells distinguished by their cytology and persistence of human papillomavirus infection, could be easily differentiated by their metabolite profile. MATERIALS & METHODS: Direct injection electrospray mass spectrometry was used in a nontargeted double-blind experiment. Samples were collected from women diagnosed with one of two grades of cervical cytology and exhibiting either human papilloma virus persistence or clearance...
May 16, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28501759/resource-utilization-for-non-operative-cervical-radiculopathy-management-by-surgeons-versus-non-surgeons
#6
Sophie H Chung, Daniel D Bohl, Jonathan T Paul, Jeffrey A Rihn, James S Harrop, Zoher Ghogawala, Alan S Hilibrand, Jonathan N Grauer
OBJECTIVES: To compare the estimated resource utilization for non-operative treatment of cervical radiculopathy if managed by surgeons versus non-surgeons. PATIENTS AND METHODS: A Cervical Spine Research Society-sponsored survey was administered at a national spine surgery conference to surgeons and non-surgeons, as classified above. The survey asked questions regarding resource utilization and perceived costs for the "average patient" with cervical radiculopathy managed non-operatively...
May 6, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28494130/visualization-of-stereoscopic-anatomic-models-of-the-paranasal-sinuses-and-cervical-vertebrae-from-the-surgical-and-procedural-perspective
#7
Jian Chen, Andrew D Smith, Majid A Khan, Allan R Sinning, Marianne L Conway, Dongmei Cui
Recent improvements in three-dimensional (3D) virtual modeling software allows anatomists to generate high-resolution, visually appealing, colored, anatomical 3D models from computed tomography (CT) images. In this study, high-resolution CT images of a cadaver were used to develop clinically relevant anatomic models including facial skull, nasal cavity, septum, turbinates, paranasal sinuses, optic nerve, pituitary gland, carotid artery, cervical vertebrae, atlanto-axial joint, cervical spinal cord, cervical nerve root, and vertebral artery that can be used to teach clinical trainees (students, residents, and fellows) approaches for trans-sphenoidal pituitary surgery and cervical spine injection procedure...
May 11, 2017: Anatomical Sciences Education
https://www.readbyqxmd.com/read/28492965/role-of-icg-99m-tc-nanocolloid-for-sentinel-lymph-node-detection-in-cervical-cancer-a-pilot-study
#8
Pilar Paredes, Sergi Vidal-Sicart, Francisco Campos, Andrés Tapias, Nuria Sánchez, Sergio Martínez, Lorena Carballo, Jaume Pahisa, Aureli Torné, Jaume Ordi, Francesc Carmona, Francisco Lomeña
PURPOSE: Sentinel lymph node biopsy (SLNB) can be used for nodal staging in early cervical cancer. For this purpose, the tracers most commonly used are radiotracers based on technetium. For the last decade, indocyanine green (ICG) has been used as a tracer for SLNB in other malignancies with excellent results and, more recently, a combination of ICG and a radiotracer has been shown to have the advantages of both tracers. The aim of this study was to evaluate the role of ICG-(99m)Tc-nanocolloid in SLN detection in patients with cervical cancer...
May 10, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28486884/effect-of-intravesical-botulinum-toxin-injection-on-symptoms-of-autonomic-dysreflexia-in-a-patient-with-chronic-spinal-cord-injury-a-case-report
#9
Il-Young Jung, Kyo Ik Mo, Ja-Ho Leigh
CONTEXT: There are few treatment options for managing autonomic dysreflexia in patients with chronic spinal cord injury (SCI). According to some studies, intravesical botulinum toxin for SCI patients with autonomic dysreflexia has a preventive effect on symptoms of autonomic dysreflexia. However, the usefulness of an intravesical botulinum toxin injection has never been reported for autonomic dysreflexia in an adult patient with chronic cervical SCI, although there has been for one pediatric patient...
May 9, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28486361/universal-cervical-length-screening-and-antenatal-corticosteroid-timing
#10
Nicole Sahasrabudhe, Catherine Igel, Ghislaine C Echevarria, Peʼer Dar, Diana Wolfe, Peter S Bernstein, Robert Angert, Ashlesha Dayal, Patience Gallagher, Mara Rosner
OBJECTIVE: To evaluate the relationship between universal transvaginal screening for short cervical length in the second trimester and the timing of antenatal corticosteroids. METHODS: We performed a retrospective cohort study of patients with nonanomalous singleton gestations and spontaneous preterm birth between 24 and 34 weeks of gestation after the initiation of a universal transvaginal cervical length screening program between October 2012 and August 2015. Our primary outcome was antenatal corticosteroid administration to a delivery interval of fewer than 7 days...
May 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28482062/cervical-epidural-depth-correlation-between-cervical-mri-measurements-of-the-skin-to-cervical-epidural-space-and-the-actual-needle-depth-during-interlaminar-cervical-epidural-injections
#11
Haitham Algrain, Alison Liu, Sarabdeep Singh, To-Nhu Vu, Steven P Cohen
Objective. : The purpose of this study was to assess the correlation between skin-to-epidural space depth, as measured on cervical magnetic resonance imaging (MRI), and actual needle depth, as measured by Tuohy needle markings during cervical epidural steroid injections. Methods. : We conducted a retrospective review of cervical MRI images to determine estimated depth from skin to epidural space. Of the 121 reviewed patients who underwent cervical epidural steroid injections, 81 met inclusion criteria and were retained for data analysis...
May 8, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28475392/is-nitric-oxide-an-essential-mediator-in-cervical-inflammation-and-preterm-birth
#12
Christopher Nold, Julie Stone, Maura Graham, Jennifer Trinh, Alex Blanchette, Todd Jensen
OBJECTIVE: Cervical ripening is an obligatory step in the process of preterm birth. We hypothesize an inflammatory challenge to the cervix leads to an increase in nitric oxide production disrupting the cervical epithelial barrier leading to preterm birth. STUDY DESIGN: For this study, three experiments were performed: (1) Using a mouse model, pregnant mice were treated with an intrauterine injection of saline or lipopolysaccharide (LPS). Mice were sacrificed and cervices were collected for molecular analysis...
May 5, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28467685/structural-alterations-in-tumor-draining-lymph-nodes-before-papillary-thyroid-carcinoma-metastasis
#13
Andrew M Hinson, Nicole A Massoll, Lee Ann Jolly, Brendan C Stack, Donald L Bodenner, Aime T Franco
BACKGROUND: The purpose of this study was to define and characterize the thyroid tumor-draining lymph nodes in genetically engineered mice harboring thyroid-specific expression of oncogenic Braf(V600E) with and without Pten insufficiency. METHODS: After intratumoral injection of methylene blue, the lymphatic drainage of the thyroid gland was visualized in real time. The thyroid gland/tumor was resected en bloc with the respiratory system for histological analysis...
May 3, 2017: Head & Neck
https://www.readbyqxmd.com/read/28466646/ultrasound-guided-transvaginal-thrombin-injection-of-uterine-arteries-pseudoaneurysms
#14
Cristina Ros, Daniel Barnes, Anna Fervienza, Gabriella Oses, Juan Luis Alcázar, Sergio Martínez-Román, Àngels Rovirosa, Francisco Carmona, Fernando Gómez
OBJECTIVE: To evaluate the utility of transvaginal ultrasound-guided thrombin injection (UGTI) to treat uterine artery pseudoaneurysms (UAP) as an alternative to emergency arterial embolization. METHODS: Two women presenting with heavy vaginal bleeding were diagnosed with UAP by pelvic CT scan. After UAP identification by transvaginal ultrasound (TVUS), 2 cc of thrombin (Tissucol(®), Baxter Healthcare Corporation. Munich, Germany) were slowly injected into the UAP using a 30 cm long 22-gauge needle through a needle-guide attached to the vaginal probe...
May 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28462399/can-letrozole-plus-hmg-protocol-improve-pregnancy-outcomes-in-frozen-thawed-embryo-transfer-an-rct
#15
Ashraf Aleyasin, Marzieh Aghahosseini, Leili Safdarian, Maryam Noorzadeh, Parvin Fallahi, Zahra Rezaeian, Sedighe Hoseinimosa
BACKGROUND: There are different methods in endometrial preparation for frozen-thawed embryo transfer (FET). OBJECTIVE: The purpose of this study was to compare the live birth rate in the artificial FET protocol (estradiol/ progesterone with GnRH-agonist) with stimulated cycle FET protocol (letrozole plus HMG). MATERIALS AND METHODS: This randomized clinical trial included 100 women (18-42 years) randomly assigned to two groups based on Bernoulli distribution...
February 2017: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28460864/ropivacaine-intramuscular-paracervical-injections-for-pediatric-headache-a-randomized-placebo-controlled-trial
#16
Susan K Yaeger, Michelle C Perry, Kerry Caperell, Keith A Coffman, Robert W Hickey
STUDY OBJECTIVE: We seek to determine whether ropivacaine cervical paraspinal injections compared with normal saline solution injections provide headache relief to pediatric patients that is sufficient for emergency department (ED) discharge. METHODS: We enrolled children aged 7 to 17 years in a double-blinded, randomized, controlled trial of patients presenting to a pediatric ED with headache. Subjects were randomized into 1 of 3 groups: bilateral cervical paraspinal injections of either (1) 0...
April 28, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28458568/cost-effectiveness-analysis-of-abobotulinumtoxina-for-the-treatment-of-cervical-dystonia-in-the-united-kingdom
#17
Madhusubramanian Muthukumar, Kamal Desai, Seye Abogunrin, Timothy Harrower, Sylvie Gabriel, Jerome Dinet
BACKGROUND: Cervical dystonia (CD) involves painful involuntary contraction of the neck and shoulder muscles and abnormal posture in middle-aged adults. Botulinum neurotoxin type A (BoNT-A) is effective in treating CD but little is known about its associated cost-effectiveness. OBJECTIVE: To evaluate the cost-effectiveness of abobotulinumtoxinA for treating CD from the UK payer perspective. METHODS: A Markov model was developed to evaluate the cost-effectiveness of abobotulinum-toxinA versus best supportive care (BSC) in CD, with a lifetime horizon and health states for response, nonresponse, secondary nonresponse, and BSC in patients with CD (mean age: 53 years; 37% male)...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28457585/-the-parapharyngeal-adipose-corpus-surgical-anatomy-and-imaging
#18
V Colin, M Gavid, A Timochenko, J M Prades
The aim of this study is to define the parapharyngeal adiposis corpus (PAC) and its anatomical relationships originally described by P. Sebileau in 1892 to assess the potential clinical implications. MATERIALS AND METHODS: Seven frozen fresh cadavers were used, 3 of which after injection of latex neoprene colored in cervicocephalic arterial network. A MRI was performed in 10 patients without cervical pathology. The analysis was done on the frontal and transverse T1-weighted sections...
April 27, 2017: Morphologie: Bulletin de L'Association des Anatomistes
https://www.readbyqxmd.com/read/28451492/recurrent-laryngeal-nerve-palsy-after-cervical-spine-surgery-a-multicenter-aospine-clinical-research-network-study
#19
Ziya L Gokaslan, Mohamad Bydon, Rafael De la Garza-Ramos, Zachary A Smith, Wellington K Hsu, Sheeraz A Qureshi, Samuel K Cho, Evan O Baird, Thomas E Mroz, Michael Fehlings, Paul M Arnold, K Daniel Riew
STUDY DESIGN: Multicenter retrospective study. OBJECTIVES: To investigate the risk of symptomatic recurrent laryngeal nerve palsy (RLNP) following cervical spine surgery, to examine risk factors for its development, and to report its treatment and outcomes. METHODS: A multicenter study from 21 high-volume surgical centers from the AOSpine North America Clinical Research Network was performed. Each center screened for rare complications following cervical spine surgery, including RLNP...
April 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28442357/dl-3-n-butylphthalide-promotes-neuroplasticity-and-motor-recovery-in-stroke-rats
#20
Yefei Sun, Xi Cheng, Huibin Wang, Xiaopeng Mu, Yifan Liang, YuJia Luo, Huiling Qu, Chuansheng Zhao
BACKGROUNDS AND AIMS: Racemic l-3-n-butylphthalide (dl-NBP), is able to achieve a functional recovery in animal models of cerebral ischemia, vascular dementia, and Alzheimer's disease. In this study, we investigated the effect of dl-NBP on axonal growth, neurogenesis and behavioral performances in rats with cerebral ischemia. METHODS: Focal cerebral ischemia in rats was produced by intracerebral injection of endothelin-1. Starting from postoperative day 7, the experimental rats were administered 70mg/kg dl-NBP by oral gavage for two weeks...
April 22, 2017: Behavioural Brain Research
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