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Cervical injection

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https://www.readbyqxmd.com/read/28629611/sentinel-lymph-node-mapping-in-minimally-invasive-surgery-role-of-imaging-with-color-segmented-fluorescence-csf
#1
Maite I Lopez Labrousse, Michael Frumovitz, M Guadalupe Patrono, Pedro T Ramirez
OBJECTIVE: Sentinel lymph node mapping, alone or in combination with pelvic lymphadenectomy, is considered a standard approach in staging of patients with cervical or endometrial cancer [1-3]. The goal of this video is to demonstrate the use of indocyanine green (ICG) and color-segmented fluorescence when performing lymphatic mapping in patients with gynecologic malignancies. METHODS: Injection of ICG is performed in two cervical sites using 1mL (0.5mL superficial and deep, respectively) at the 3 and 9 o'clock position...
June 16, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28626980/comparison-of-management-regimens-following-ultrasound-diagnosis-of-nontubal-ectopic-pregnancies-a-retrospective-cohort-study
#2
J Ramkrishna, G R Kan, K L Reidy, W C Ang, R Palma-Dias
OBJECTIVE: To review management options for nontubal ectopic pregnancies. DESIGN: Retrospective cohort study. SETTING: Tertiary hospital in Melbourne, Australia. POPULATION: A total of 100 nontubal pregnancies: 1 abdominal, 32 caesarean scar, 14 cervical, 41 cornual-interstitial, 12 ovarian. METHODS: Cases were classified according to ectopic site. Management categories were medical, surgical, combination or expectant...
June 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28625856/nitroglycerin-increases-serotonin-transporter-expression-in-rat-spinal-cord-but-anandamide-modulated-this-effect
#3
Gábor Nagy-Grócz, Zsuzsanna Bohár, Annamária Fejes-Szabó, Klaudia Flóra Laborc, Eleonóra Spekker, Lilla Tar, László Vécsei, Árpád Párdutz
Migraine is one of the most prevalent neurological diseases, which affects 16% of the total population. The exact pathomechanism of this disorder is still not well understood, but it seems that serotonin and its transporter have a crucial role in the pathogenesis. One of the animal models of migraine is the systemic administration of nitroglycerin (NTG), a nitric oxide (NO) donor. NO can initiate a central sensitization process in the trigeminal system, which is also present in migraineurs. Recent studies showed that the endocannabinoid system has a modulatory role on the trigeminal activation and sensitization...
June 15, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28625394/sentinel-node-mapping-in-endometrial-cancer-following-hysteroscopic-injection-of-tracers-a-single-center-evaluation-over-200-cases
#4
Fabio Martinelli, Antonino Ditto, Mauro Signorelli, Giorgio Bogani, Valentina Chiappa, Domenica Lorusso, Cono Scaffa, Dario Recalcati, Stefania Perotto, Edward Haeusler, Francesco Raspagliesi
OBJECTIVES: To analyze detection-rate(DR) and diagnostic-accuracy (A) of sentinel-nodes(SLNs) mapping following hysteroscopic-injection of tracer. To compare DR and A between tracers: ICG and Tc99m. METHODS: Evaluation of endometrial-cancer patients who underwent SLNs mapping after hysteroscopic-peritumoral-injection of tracer±lymphadenectomy. Analysis of DR (overall-bilateral-aortic) and A in the entire cohort and comparison between tracers. RESULTS: 202 procedures were performed from January/2005 to February/2017...
June 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28624196/evaluation-of-antisense-oligonucleotides-targeting-atxn3-in-sca3-mouse-models
#5
Lauren R Moore, Gautam Rajpal, Ian T Dillingham, Maya Qutob, Kate G Blumenstein, Danielle Gattis, Gene Hung, Holly B Kordasiewicz, Henry L Paulson, Hayley S McLoughlin
The most common dominantly inherited ataxia, spinocerebellar ataxia type 3 (SCA3), is an incurable neurodegenerative disorder caused by a CAG repeat expansion in the ATXN3 gene that encodes an abnormally long polyglutamine tract in the disease protein, ATXN3. Mice lacking ATXN3 are phenotypically normal; hence, disease gene suppression offers a compelling approach to slow the neurodegenerative cascade in SCA3. Here we tested antisense oligonucleotides (ASOs) that target human ATXN3 in two complementary mouse models of SCA3: yeast artificial chromosome (YAC) MJD-Q84...
June 16, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28619385/rectum-and-bladder-spacing-in-cervical-cancer-brachytherapy-using-a-novel-injectable-hydrogel-compound-traceit
#6
Antonio L Damato, Megan Kassick, Akila N Viswanathan
PURPOSE: The aim of this study was to evaluate injection of a novel hydrogel (TraceIT; Augmenix, Waltham, MA) between the cervix, rectum, and bladder in female cadavers compared with, and in addition to, the current standard of gauze packing, for organ-at-risk sparing in cervical cancer brachytherapy planning. METHODS AND MATERIALS: This brachytherapy cadaver study used T2-weighted MRI and CT imaging to compare three scenarios: (1) gauze packing alone, (2) hydrogel injection placed in the cervical fornices and rectovaginal septum, and (3) gauze packing in conjunction with hydrogel injection...
June 12, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28605794/subdural-extra-arachnoid-flow-pattern-visualized-in-a-contralateral-oblique-view-during-a-cervical-interlaminar-epidural-steroid-injection
#7
David Levi
No abstract text is available yet for this article.
June 1, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28604409/posture-dependent-dysphagia-after-botulinum-toxin-type-a-injection-at-sternocleidomastoid-in-a-patient-with-athetoid-cerebral-palsy
#8
Won Kee Chang, Keewon Kim, Han Gil Seo, Ja-Ho Leigh, Moon Suk Bang
Cervical dystonia is a common issue in patients with athetoid cerebral palsy. Botulinum toxin injection to dystonic cervical muscles is a well-recognized treatment option, but it is known to be associated with dysphagia. Previously reported cases of dysphagia after botulinum toxin injection to the sternocleidomastoid muscle were related to the regional spread of toxin to the pharyngeal muscles. We report a unique case of posture-dependent dysphagia due to preactivation of the suprahyoid and infrahyoid muscles to compensate for impaired head stabilization by the weakened sternocleidomastoid muscle while swallowing...
June 9, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28599791/characterization-of-hpv18-e6-specific-t-cell-responses-and-establishment-of-hpv18-e6-expressing-tumor-model
#9
Ying Ma, Andrew Yang, Shiwen Peng, Jin Qiu, Emily Farmer, Chien-Fu Hung, T-C Wu
Human papillomavirus (HPV) has been identified as the primary etiologic factor of cervical cancer, and subsets of anogenital and oropharyngeal cancers. HPV18 is the second most prevalent high-risk HPV type after HPV16. Furthermore, HPV18 is responsible for approximately 12% of cervical squamous cell carcinoma and 37% of cervical adenocarcinoma cases worldwide. In this study, we aimed to characterize the HPV18-E6-specific epitope and establish an HPV18 animal tumor model to evaluate the E6-specific immune response induced by our DNA vaccine...
June 6, 2017: Vaccine
https://www.readbyqxmd.com/read/28598086/-high-mobility-group-chromosomal-protein-n2-inhibit-cervical-cancer-transplanted-in-nude-mice
#10
Bin Luo, Qian-Wen Zhang, Yu Xu, Jian Meng, Xiao-Li Wang, Lin Li, Yue-Dong He
OBJECTIVES: To study the effect of high mobility group chromosomal protein N2 on inhibiting cervical cancer in nude mice. METHODS: Model of cervical cancer were established in nude mice. They were randomly divided into 4 groups including negative control group, HMGN2 group, cisplatin group and HMGN2 with cisplatin group. After 4 injections, the tumor size were calculated and tumor tissues were stained by haematoxylin eosin (HE) staining. RESULTS: Transplated tumor models were established successfully...
September 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28591865/reliability-and-accuracy-of-mri-laminar-angle-measurements-to-determine-intraprocedural-contralateral-oblique-view-angle-for-cervical-or-thoracic-interlaminar-epidural-steroid-injections-safety-before-accuracy
#11
Jatinder Gill, Thomas Simopoulos
No abstract text is available yet for this article.
June 7, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28586112/conservative-management-of-cervical-ectopic-pregnancy-single-center-experience
#12
Semih Zeki Uludag, Mehmet Serdar Kutuk, Ercan Mustafa Aygen, Yılmaz Sahin
AIM: The aim of this study was to assess the results of conservative treatment of cervical ectopic pregnancy (CEP). METHODS: We retrospectively reviewed all cervical ectopic pregnancies diagnosed at the present department between January 2010 and July 2015. Patients with CEP who were treated with either systemic or intra-amniotic methotrexate (MTX) injection were included in the study. RESULTS: Ten CEP patients were identified. Median maternal age was 33 years (range, 23-40 years)...
June 6, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28583461/repair-of-v2-vertebral-artery-injuries-sustained-during-anterior-cervical-discectomy
#13
Evgenii Belykh, David S Xu, Kaan Yağmurlu, Ting Lei, Vadim A Byvaltsev, Curtis A Dickman, Mark C Preul, Peter Nakaji
BACKGROUND: The V2 segment of the vertebral artery (VA) typically runs through the transverse foramen of C2-C6. V2 injury may occur during anterior approaches to the cervical spine and can cause significant morbidity. We aimed to describe landmarks and microsurgical V2 repair techniques through the standard anterolateral cervical discectomy approach. METHODS: Five silicone-injected cadaveric heads (necks-C7) were dissected bilaterally. An anterolateral approach with C3-4, C4-5, and C5-6 discectomies and an ipsilateral VA injury were simulated...
June 2, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28576715/thermo-sensitive-polypeptide-hydrogel-for-locally-sequential-delivery-of-two-pronged-antitumor-drugs
#14
Lingyu Wei, Jinjin Chen, Shuhua Zhao, Jianxun Ding, Xuesi Chen
In the synergistic treatment with cytotoxic drug and vascular disrupting agent, the order of drug release shows great importance to enhance the antitumor efficacy. When vascular disrupting agent is firstly administrated, the reduced blood supply and overexpressed hypoxia-inducible factor-1α greatly limit the efficiency of chemotherapy. In this work, an injectable thermo-sensitive polypeptide hydrogel was firstly developed for the locally sequential delivery of hydrophilic doxorubicin (DOX, a cytotoxic agent) and hydrophobic combretastatin A4 (CA4, a vascular disrupting drug)...
May 30, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28575843/down-regulation-of-mrps23-inhibits-rat-breast-cancer-proliferation-and-metastasis
#15
Yan Gao, Fuyan Li, Hong Zhou, Yi Yang, Ruimin Wu, Yijia Chen, Wei Li, Yang Li, Xueqin Xu, Changbin Ke, Zhijun Pei
Mitochondrial ribosomal protein S23 (MRPS23) has been shown to be involved in breast cancer cell proliferation and metastatic phenotypes of cervical cancer. Here we investigated its biological features in breast cancer for the first time. It demonstrated that knockdown of MRPS23 reduced breast cancer cell proliferation and induced apoptosis in vitro. Besides, shRNA targeting MRPS23 (shMRPS23) inhibited tumour proliferation and metastasis by blocking tumor angiogenesis in breast cancer xenograft rat model. Small animal positron emission tomography/computed tomography (PET/CT) with 2'-deoxy-2'-[18F] fluoro-D-glucose (FDG) was performed at four weeks after tumour cell injection...
May 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28571789/virtual-reality-based-simulators-for-spine-surgery-a-systematic-review
#16
REVIEW
Michael Pfandler, Marc Lazarovici, Philipp Stefan, Patrick Wucherer, Matthias Weigl
BACKGROUND CONTEXT: Virtual reality (VR) based simulators offer numerous benefits and are very useful in assessing and training surgical skills. Although they are standard in some surgical subspecialties, their actual use in spinal surgery remains unclear. Currently, only technical reviews of VR based simulators are available for spinal surgery. PURPOSE: Thus, we performed a systematic review which examined the existing research on VR based simulators in spinal procedures...
May 29, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28558869/triptolide-reduces-prostate-size-and-androgen-level-on-testosterone-induced-benign-prostatic-hyperplasia-in-sprague-dawley-rats
#17
Yu-Rong Wang, Yuan Xu, Zhen-Zhou Jiang, Lu-Yong Zhang, Tao Wang
Benign prostatic hyperplasia (BPH) is an age-related disease of unknown etiology, characterized by prostatic enlargement coincident with distinct alterations in tissue histology. In the present study, we investigated whether triptolide can prevent testosterone-induced prostatic hyperplasia in rats. Castration was performed via the scrotal route after urethane aesthesia. BPH was induced in experimental groups by daily subcutaneous injections of testosterone propionate (TP) for two weeks. Triptolide was administered daily by oral gavage at a dose of 100 and 50 μg·kg(-1) for 2 weeks, along with the TP injections...
May 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28553170/new-optimal-needle-entry-angle-for-cervical-transforaminal-epidural-steroid-injections-a-retrospective-study
#18
Myong-Hwan Karm, Jun Young Park, Doo Hwan Kim, Hyun-Seok Cho, Jae-Young Lee, Koo Kwon, Jeong Hun Suh
Objective: A cervical epidural steroid injection is one of the most commonly performed interventions to manage chronic neck pain and cervical radiculopathy. Despite its many severe complications, cervical transforaminal epidural steroid injection (CTFESI) is a clinically necessary modality for managing neck pain and cervical radiculopathy. We aimed in this study to find a safer optimal needle entry angle to decrease the chance of an accidental vertebral artery (VA) puncture even with a proper needle entry angle and to visualize the target of the needle tip...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/28551895/-sentinel-lymph-nodes-dissection-in-gynecological-malignancies
#19
REVIEW
Yael Naaman, Limor Goldenhersh, Alon Ben-Arie
During the last decade sentinel lymph nodes biopsy has become an essential part of primary surgical treatment in a number of malignancies including breast cancer, melanoma and head-and-neck malignancies. Dye or radioactive substances are injected at the primary tumor site, followed by pre-operative and intra-operative mapping. During surgery only positive lymph nodes are being dissected instead of a complete dissection of the lymphatic basin. The advantages of sentinel lymph nodes dissection are reducing the side effects of extensive lymph nodes dissection, while maintaining high detection rates and sensitivity in identifying cases with lymphatic tumor spread...
February 2017: Harefuah
https://www.readbyqxmd.com/read/28547914/the-branching-pattern-of-the-brachiocephalic-trunk-in-the-donkey-equus-asinus
#20
G Akbari, B Asadiahranjani, N Goodarzi, S Shokrollahi
Donkeys are a member of the horse family (Equidae) and share a common ancestor. However, in morphological terms, donkeys and horses are regarded as two separate subgenus. Given variations in the branching pattern of the brachiocephalic trunk (BCT) in different species of animals and the use of donkeys in anatomy courses at colleges of veterinary medicine, we conducted this study in order to investigate the branching patterns of BCT and to describe detailed morphological information regarding donkeys. Seventeen mature donkeys were examined following euthanasia by exsanguination from the common carotid artery under general anaesthesia...
May 26, 2017: Anatomia, Histologia, Embryologia
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