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Cervical injection

Ahmed Al-Dam, Clarissa Precht, Armelle Barbe, Carsten Kohlmeier, Henning Hanken, Johannes Wikner, Gerhard Schön, Max Heiland, Alexandre T Assaf
PURPOSE: The purpose of this clinical study was to evaluate the sensitivity and specificity of cervical sentinel lymph node biopsy after mapping with indocyanine green fluorescence (ICG) for imaging early-stage oral cancer. PATIENTS AND METHODS: A sentinel lymph node biopsy (SLNB) was performed during a selective neck dissection (SND) in 20 patients with oral squamous cell carcinoma (OSCC, cT1 or cT2, N0 status). The sentinel lymph nodes (SLN) were identified using an infrared video camera after ICG injection...
May 23, 2018: Journal of Cranio-maxillo-facial Surgery
Kaila A Holtz, Elena Szefer, Vanessa K Noonan, Brian K Kwon, Patricia B Mills
STUDY DESIGN: Prospective cohort study using the Rick Hansen SCI Registry (RHSCIR) and retrospective medical chart review. OBJECTIVE: To describe treatment patterns of in-patient anti-spasticity medication use following traumatic spinal cord injury (SCI) in acute and rehabilitation hospital settings in British Columbia, Canada. SETTING: Quaternary trauma center, rehabilitation center. METHODS: Individuals with traumatic SCI between 2005 and 2014 enrolled in the Vancouver RHSCIR site (N = 917) were eligible for inclusion...
June 14, 2018: Spinal Cord
Yuyuan Zhang, Xue Chen, Yun Wang, Chunhua Wang
OBJECTIVE: To investigate the oxidative damage induced by cadmium choride and the expression of nuclear factor κB( NF-κB), tumor necrosis factor-α( TNF-α) and intercellular cell adhesion molecule-1( ICAM-1) in brain tissue of mice. METHODS: A total of 32 adult ICR mice were divided into 4 groups randomly including CdCl_2 2. 0, 1. 0 and 0. 5 mg/kg and NS control group, all mice were through intraperitoneally injected administration for 14 days, after the last exposure, open-field test were used and all mice were sacrificed by cervical dislocation, the expression of reactive oxygen species( ROS)was measured and the expression of TNF-α, ICAM-1 were observed by ELISA, the level of NF-κB P65 in the brain were detected by immunohistochemistry and western blot, the slices of the brain were stained with HE for histopathological examination...
September 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
Biswarup Ghosh, Zhicheng Wang, Jia Nong, Mark W Urban, Zhiling Zhang, Victoria A Trovillion, Megan C Wright, Yinghui Zhong, Angelo C Lepore
We developed an innovative biomaterial-based approach to repair the critical neural circuitry that controls diaphragm activation by locally delivering brain-derived neurotrophic factor (BDNF) to injured cervical spinal cord. BDNF can be used to restore respiratory function via a number of potential repair mechanisms; however, widespread BDNF biodistribution resulting from delivery methods such as systemic injection or lumbar puncture can lead to inefficient drug delivery and adverse side effects. As a viable alternative, we developed a novel hydrogel-based system loaded with polysaccharide-BDNF particles self-assembled by electrostatic interactions that can be safely implanted in the intrathecal space for achieving local BDNF delivery with controlled dosing and duration...
June 11, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Aimi Nadia Binti Razlan, Muzammil Ullah, Marina Yurievna Kapitonova, Norhayati Binti Liaqat Ali Khan, Syed Baharom Syed Ahmad Fuad
The aim of the study was to investigate the location of motor neuron somata of geniohyoid muscle in rat. Nine Sprague-Dawley rats were used in this study. Operations were performed under general anaesthesia. Nembutal sodium, 40 mg per kg intraperitoneally was used for anaesthesia. 0.02 to 0.05 ml of 30% horseradish peroxidase (Sigma Type VI) solution in normal saline was injected into the exposed right geniohyoid muscle. After 48 hr, the animals were fixed by perfusion through left ventricle of heart, first by 100 ml normal saline and then with 500 ml of 1...
June 11, 2018: Anatomia, Histologia, Embryologia
Vladimir Gilca, Jorge Salmerón-Castro, Chantal Sauvageau, Gina Ogilvie, Monique Landry, Monica Naus, Eduardo Lazcano-Ponce
Although human papillomavirus (HPV) vaccines were initially licensed based on efficacy after three-dose regimens in women aged 15-26 years, it was recognized early in clinical development that comparable immunogenicity could be obtained after just two doses when administered to younger girls. In both Canada and Mexico, public health authorities made the decision to administer two doses 6 months apart with a planned additional dose at 60 months, while simultaneously doing further study to determine if the third dose would confer meaningful additional benefit...
June 7, 2018: Vaccine
Kemal Ozgur, Hasan Bulut, Murat Berkkanoglu, Faruk O Basegmez, Kevin Coetzee
In this study, the endometrial developmental and reproductive outcomes of frozen embryo transfers (FETs) which were performed subsequent to miscarriages managed by dilation and curettage (D and C) were investigated. The intracytoplasmic sperm injection (ICSI) blastocyst freeze-all cycles performed between January 2014 and August 2016 were screened for the patients who had undergone their FET (first), miscarriages (>5 < 14 weeks), D and C, and the patients who had undergone their FET (second) (study group; n = 71); and patients who underwent FET (1st), a chemical pregnancy loss (PL) (<5 weeks) and FET (2nd) (reference group; n = 38)...
June 8, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Kausar Jabeen, Jagadeeswari Karuppaswamy
The aim of this paper is to review the diagnosis and treatment of patients with a caesarean scar pregnancy (CSP), who have been managed at our unit, as well as to evaluate the effectiveness of the non-surgical treatment options. Twenty-six cases were identified over a period of 5 years and 4 months (January 2012 until April 2017). The main outcome measures were a number of previous caesarean births, a method of diagnosis of CSP, the mode of treatment and the outcome. The diagnostic criteria on the ultrasound were an empty uterine cavity and cervical canal, the presence of a gestational sac anterior to the isthmic portion of the uterus, an absent or thinned (<5 mm) myometrial thickness between the gestational sac and the bladder, with a peri-trophoblastic circulation around the gestational sac with the colour flow Doppler examination...
June 8, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Onur Levent Ulusoy, Deniz Alis, Ayhan Mutlu, Bulent Colakoglu, Mustafa Sirvanci
BACKGROUND: Computed tomography (CT)-guided cervical nerve injections are broadly being used in the treatment of cervical radiculopathy; however, catastrophic complications have been reported. Herein, we aimed to evaluate the efficacy, feasibility, and safety of a novel CT-guided cervical injection technique. MATERIALS AND METHODS: We prospectively performed cervical injections in 28 patients with cervical radiculopathies using a novel CT-guided cervical transforaminal injection technique; lateral peri-isthmic approach in which the tip of the needle advanced to the lateral cortex of the isthmus instead of the foraminal area...
June 7, 2018: Skeletal Radiology
Kazuyoshi Kobayashi, Shiro Imagama, Kei Ando, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Satoshi Tanaka, Masaaki Machino, Kyotaro Ota, Yoshihiro Nishida, Naoki Ishiguro
STUDY DESIGN: Single-center retrospective study. PURPOSE: To optimize the perioperative management of patients with hemophilia who are undergoing spinal surgery. OVERVIEW OF LITERATURE: Hemophilia is a rare disease in which there is a tendency of bleeding because of a congenital deficiency in blood coagulation factor activity. There has been no previous report on spinal surgery in patients with hemophilia. METHODS: The subjects were five patients (all males) with hemophilia who underwent spinal surgery at Nagoya University Hospital...
June 2018: Asian Spine Journal
Tim Hahn, Marc-Eric Halatsch, Christian Wirtz, Stephan Klessinger
BACKGROUND: Among the various causes of vertigo, the so-called cervicogenic vertigo (CV) has been the most controversial. However, perturbations of proprioceptive signals and abnormal activity of the cervical afferents can induce vertigo. Medial branch blocks (MBBs) are a diagnostic tool designed to test whether a patient's neck pain is mediated by one or more of the medial branches of the dorsal rami of the spinal nerve. It is unknown whether MBBs are also suitable for testing symptoms other than pain...
May 2018: Pain Physician
Juan Martinez-Pinna, Sergi Soriano, Eva Tudurí, Angel Nadal, Fernando de Castro
Ca2+ -activated ion channels shape membrane excitability in response to elevations in intracellular Ca2+ . The most extensively studied Ca2+ -sensitive ion channels are Ca2+ -activated K+ channels, whereas the physiological importance of Ca2+ -activated Cl- channels has been poorly studied. Here we show that a Ca2+ -activated Cl- currents (CaCCs) modulate repetitive firing in mouse sympathetic ganglion cells. Electrophysiological recording of mouse sympathetic neurons in an in vitro preparation of the superior cervical ganglion (SCG) identifies neurons with two different firing patterns in response to long depolarizing current pulses (1 s)...
2018: Frontiers in Physiology
Ning Qu, René Lindstrøm, Rogerio Pessoto Hirata, Thomas Graven-Nielsen
Aims Evaluate pressure pain threshold (PPT) over cervical facet joints before and after injection of experimental pain in the trapezius and multifidus muscles. Methods Fourteen healthy subjects (6 women) received randomized ultrasound-guided injections of hypertonic saline (5.8%), in the right multifidus muscle medial to C4/C5 facet joint and in the right trapezius muscle at the midpoint between C7 spinous process and acromion. The saline-induced pain intensity was assessed on a VAS scale. Before and during saline-induced pain PPTs were assessed by pressure algometry bilaterally over C2/C3 and C5/C6 facet joints...
December 29, 2017: Scandinavian Journal of Pain
Yeni H Yücel, Kirsten Cardinell, Shireen Khattak, Xun Zhou, Michael Lapinski, Fang Cheng, Neeru Gupta
Purpose: To visualize and quantify lymphatic drainage of aqueous humor from the eye to cervical lymph nodes in the dynamic state. Methods: A near-infrared tracer was injected into the right eye anterior chamber of 10 mice under general anesthesia. Mice were imaged with photoacoustic tomography before and 20 minutes, 2, 4, and 6 hours after injection. Tracer signal intensity was measured in both eyes and right and left neck lymph nodes at every time point and signal intensity slopes were calculated...
June 1, 2018: Investigative Ophthalmology & Visual Science
Abel Torres-Espín, Juan Forero, Keith K Fenrich, Ana M Lucas-Osma, Aleksandra Krajacic, Emma Schmidt, Romana Vavrek, Pamela Raposo, David J Bennett, Phillip G Popovich, Karim Fouad
Rehabilitative training is one of the most successful therapies to promote motor recovery after spinal cord injury, especially when applied early after injury. Polytrauma and management of other medical complications in the acute post-injury setting often preclude or complicate early rehabilitation. Therefore, interventions that reopen a window of opportunity for effective motor training after chronic injury would have significant therapeutic value. Here, we tested whether this could be achieved in rats with chronic (8 weeks) dorsolateral quadrant sections of the cervical spinal cord (C4) by inducing mild neuroinflammation...
May 30, 2018: Brain: a Journal of Neurology
Gregory D Schroeder, Mark F Kurd, Christopher K Kepler, Kris E Radcliff, Mitchell G Maltenfort, Hamadi Murphy, Jeffery A Rihn, D Greg Anderson, Alan S Hilibrand, Alexander R Vaccaro
STUDY DESIGN: Retrospective case-control study. BACKGROUND: Physician-owned specialty hospitals focus on taking care of patients with a select group of conditions. In some instances, they may also create a potential conflict of interest for the surgeon. The effect this has on the surgical algorithm for patients with degenerative cervical spine conditions has not been determined. METHODS: A retrospective review of all patients who underwent a 1- or 2-level anterior cervical discectomy and fusion between October 2009 and December 2014 at either a physician-owned specialty hospital or an independently owned community hospital were identified...
June 2018: Clinical Spine Surgery
Fang Shi, Yue Yang, Jian Chen, Yan Sha, Yilai Shu, Haitao Wu
Objective: To investigate the potential use of indirect computed tomography lymphography (CT-LG) with dendrimer-entrapped gold nanoparticles (Au DENPs) in the localization and enhanced imaging of cervical sentinel lymph node (SLN) on rabbit model. Methods: Twelve rabbits were randomly divided into two groups: the positive control group and the experimental group. In the control group, indirect CT-LG was performed with the injection of 0.5 ml activated carbon nanoparticles (ACNP) and Omnipaque mixture suspension in the right tongue submucosa...
2018: BioMed Research International
Sherveen N Parivash, Peter G Kranz, Linda Gray, Timothy J Amrhein
OBJECTIVE: The purpose of this study was to assess the rate of inadvertent injection into the retrodural space of Okada during CT fluoroscopy-guided interlaminar epidural steroid injection in the cervical spine. MATERIALS AND METHODS: Images from cases of cervical interlaminar epidural steroid injection under CT fluoroscopic guidance performed at a single institution between November 2009 and November 2015 were obtained and reviewed. For all cases, the following information was recorded: presence or absence of contrast material within the Okada space, cervical anatomic level at which the procedure was performed, laterality of approach, trainee presence, and years of proceduralist experience...
May 29, 2018: AJR. American Journal of Roentgenology
Yosuke Nakatani, Masayuki Kurose, Shiho Shimizu, Mana Hasegawa, Nobuyuki Ikeda, Kensuke Yamamura, Ritsuo Takagi, Keiichiro Okamoto
This study aimed to determine whether psychophysical stress conditionings had facilitatory effects on masseter muscle nociception in the central nervous system via serotonergic mechanisms in rats. Two experiments were conducted to assess: (1) whether repeated forced swim stress for 3 days increased the number of Fos-positive neurons evoked by masseter muscle injury due to formalin injection; and (2) whether serotonin-reuptake inhibitor, fluoxetine, administered daily after each stress conditioning, had modulatory roles on Fos expression...
May 28, 2018: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
G R Özalp, A Yavuz, I Seker, D Udum-Küçükşen, A Rişvanlı, Y Korlu
A new protocol with aglepristone to induce parturition in ewes with pregnancy toxemia has been reported in the present manuscript. Four experimental groups were defined: Group AG5 (n = 10), Group DEX (n = 10), Group NC (n = 5) and Group PT (n = 5) in which ewes were injected twice with 10 mg/kg of aglepristone and 5 ml dexamethasone in first two groups, respectively; whereas negative control and pregnancy toxemia groups received no treatment for parturition induction. Different clinical parameters associated with parturition in ewes and their newborns were investigated...
May 4, 2018: Theriogenology
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