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Ossifying fibroma

Marco Mele, Lars Rolighed, MarieLouise Jespersen, Lars Rejnmark, Peer Christiansen
INTRODUCTION: Cancer in the parathyroid gland is rare, but parathyroid cancer is occasionally seen in relation to genetic abnormalities. Due to a limited amount of evidence, the optimal handling of these cases is not clear. Furthermore, the presence of a malignant parathyroid tumor is rarely known at the time of the initial operation; therefore, re-operations are often necessary. The aim of this study was to present the case of a patient with a previously diagnosed jaw tumor and parathyroid carcinoma that presents as a recurrence of hyperparathyroid hypercalcemia...
April 2016: International Journal of Endocrinology and Metabolism
Yan Chen, Da-Yan Hu, Ting-Ting Wang, Ran Zhang, Qing Dong, Zhi-Xiu Xu, Lin Wang, Tie-Jun Li
BACKGROUND: The tumor suppressor gene CDC73 was found to be associated with hyperparathyroidism-jaw tumor syndrome (HPT-JT), which is characterized by parathyroid adenoma or carcinoma, ossifying fibroma (OF) of the jaws, and renal and uterine lesions. Mutations in CDC73 have also been frequently detected in sporadic parathyroid carcinomas and renal tumors. However, the prevalence and range of CDC73 mutations in sporadic OFs have not been established. METHODS: We directly sequenced coding and flanking splice junctional regions of CDC73 in 40 cases of sporadic OF of the jaws...
2016: Diagnostic Pathology
Hannah du Preez, Ashok Adams, Polly Richards, Simon Whitley
: Hyperparathyroidism jaw tumour syndrome is a rare autosomal dominant inherited endocrine neoplasia syndrome, which predisposes carriers to develop a triad of multiple ossifying fibromas of the maxilla and mandible, parathyroid adenomas and carcinomas (with consequent hyperparathyroidism) as well as renal and uterine tumours. The prevalence of this condition is unknown. Patients typically present initially with symptoms and signs of a jaw tumour. A high index of suspicion is required for the underlying diagnosis to be recognised, enabling appropriate management of jaw lesions, treatment of hyperparathyroidism, if present, as well as early detection of malignant disease and screening of family members...
September 21, 2016: Insights Into Imaging
Joseph Wolfgang Mathews, Rhonda Winchester, Nebras Alsaygh, Anne M Bartlett, Louis Luttrell
Ossifying fibromas of the maxillofacial bones are an uncommon form of benign neoplasm usually treated by surgical excision. Up to 30% of patients with hyperparathyroidism-jaw tumor syndrome, a rare form of multiple endocrine neoplasia resulting from autosomal dominant inactivating mutation of the Hrpt2 tumor suppressor gene, initially present with ossifying fibromas. Coincident hypercalcemia because of the presence of parathyroid adenoma is common in these patients, of whom 15% may have or may develop parathyroid carcinoma...
September 2016: American Journal of the Medical Sciences
Praveen Ganesh, Rohan P Raut, Kiran Kumar Boyina, Samarth Shetty, Paul C Salins
Ossifying fibroma is a rare benign osteogenic neoplasm arising from undifferentiated cells of the periodontal ligament. Ossifying fibroma have a well-defined border that differentiates it from fibrous dysplasia clinically; these tumors manifest as a round or ovoid, expansile, painless, slow-growing mass may displace the roots of adjacent teeth and also cause root resorption. A variety of approaches for resection of the maxilla have been described. Most involve the use of facial and lip-splitting incisions to gain wide access...
October 2016: Journal of Craniofacial Surgery
Paras B Patel, John M Wright, Paul P Chang
No abstract text is available yet for this article.
May 2016: Texas Dental Journal
B Murphy, D M Imai
A cutaneous proliferative mass was identified arising from the caudal peduncle of a captive neon tetra fish (Paracheirodon innesi). The lesion was histologically consistent with an ossifying fibroma (OF), a fibro-osseous proliferative lesion typically identified in the jaws or tooth-associated supportive tissues of mammals. Although it has been previously reported, there is no recent report of this lesion occurring in a fish. This is the first report of a cutaneous ossifying fibroma in a characin fish. The authors speculate on the pathogenesis of this lesion, which may have arisen from the scale-associated mesenchymal tissues...
August 2016: Journal of Comparative Pathology
Tina Shooshtarizadeh, Mandana Rahimi, Sajjadeh Movahedinia
INTRODUCTION: Giant cell tumor of bone (GCTOB) is a locally aggressive neoplasm that accounts for 5% of all primary bone tumors. This tumor overlaps in histopathologic and radiographic presentations with different malignant, benign, and metabolic giant cell-rich lesions. The purpose of this study is to evaluate p63 expression status in giant cell tumor of bone in comparison with other giant cell-rich lesions. MATERIALS AND METHODS: In a cross-sectional study we examined immunohistochemical expression of p63 in a series of 100 giant cell-rich bone lesions, including 31 giant cell tumors of bone, 14 osteosarcomas (including 3 giant cell-rich variants), 18 aneurysmal bone cysts (including one solid variant), 8 non-ossifying fibromas, 17 chondroblastomas, 8 tenosynovial giant cell tumors, and 4 brown tumors...
July 14, 2016: Pathology, Research and Practice
Carlos Cotúa Quintero, Anwar Saab Mazzei, Juan Revuelta Barbero, Avelino Parajon Diaz, Luis Ley Urzaiz
BACKGROUND: Ossifying fibroma is a rare benign bone tumor that occurs mostly in the jaw, but also affects paranasal sinuses and fronto-ethmoidal complex. Occipital bone is an extremely rare location for these tumors; only two cases have been reported. METHODS: We present the first case reported as psammomatoid subtype of ossifying fibroma, according to the 2005 WHO classification. An 18 years old male patient with infratentorial tumor, in the occipital bone, that produces mass effect over the cerebellum...
2016: SpringerPlus
Paolo Cariati, Fernando Monsalve Iglesias, José Fernández Solís, Alfredo Valencia Laseca, Ildefonso Martinez Lara
Cherubism is a rare disorder with autosomal dominant inheritance. It is classified as a benign fibro-osseous lesions and may involve either facial bone. Its typical dentofacial deformities are caused by mutations in the SH3BP2 gene. The protein encoded by SH3BP2 had a significant role in the regulation of osteoblasts and osteoclasts. Accordingly with the radiological findings, differential diagnoses includes fibrous dysplasia, giant cell granuloma, osteosarcoma, juvenile ossifying fibroma, fibrous osteoma, odontogenic cyst and hyperparathyroidism...
July 11, 2016: Reumatología Clinica
N Choudhury, A Hariri, H Saleh
OBJECTIVE: The endoscopic modified Lothrop procedure is mainly used for refractory frontal sinusitis. However, we have used it as an access procedure to facilitate treatment for an extended range of additional frontal sinus pathologies. METHODS: A retrospective review of patients who underwent the endoscopic modified Lothrop procedure for 'alternative' frontal sinus pathologies was conducted. Patient data were reviewed. The main outcome parameter measured was signs of recurrence...
September 2016: Journal of Laryngology and Otology
Nirmal Raj Gopinathan, Mahesh Prakash, Balaji Saibaba, Ashim Das
Osteofibrous dysplasia or ossifying fibroma is an uncommon benign fibro-osseous lesion of childhood, commonly described in the maxilla and the mandible. Among long bones, it usually presents in the tibia as a painless swelling or anterior bowing. Ossifying fibroma of clavicle has never been reported in English literature, to the best of our knowledge. Here, we would like to present an unusual case of osteofibrous dysplasia of clavicle clinically mimicking chronic osteomyelitis.
April 2016: Indian Journal of Radiology & Imaging
Rodrigo Cárdenas-Perilla, Consuelo Santamaria, Juan Manuel Muñoz-Acosta
Juvenile psammomatoid ossifying fibroma is a rare bone-forming tumor seen in craniofacial bones, which affects mainly young patients. We report scintigraphic and SPECT/CT findings of 2 patients diagnosed with this disease. One patient presented with suspicion of fibrous dysplasia and the other with suspected malignancy in the setting of a rapidly growing mass. Both cases highlight the importance of recognizing this type of tumor in young patients with abnormal uptake in paranasal bones and sinuses within the range of potential differential diagnoses including sarcomas, fibrous dysplasia, and odontogenic tumors...
September 2016: Clinical Nuclear Medicine
G N Mainville, D P Turgeon, A Kauzman
Benign fibro-osseous lesions of the maxillofacial skeleton constitute a heterogeneous group of disorders that includes developmental, reactive (dysplastic) and neoplastic lesions. Although their classification has been reviewed multiple times in the past, the most common benign fibro-osseous lesions are fibrous dysplasia, osseous dysplasia and ossifying fibroma. For the dental clinician, the challenges involve diagnosis and treatment (or lack thereof). A careful correlation of all clinical, radiologic and microscopic features is essential to establish a proper diagnosis and a clear treatment plan...
July 7, 2016: Oral Diseases
Alberto Merlini, Joseph Garibaldi, Luca Giorgis, Paolo Balbi
Gnathodiaphyseal dysplasia (GDD) is a rare hereditary syndrome characterized by cemento-ossifying fibromas of the maxillary bones, fragile bones, curvature and cortical thinning of the tubular bones, and diaphyseal sclerosis of the long bones. In this study, 2 complex clinical cases of 2 members of the same family had GDD and were treated in the authors' odonto-stomatology department. The first was treated with a block bone graft and implant-prosthetic therapy; the other, who had extensive osteomyelitis of the second quadrant, was managed with extraction of the involved teeth, surgical revision of the site, and a graft of autologous platelet concentrate...
June 14, 2016: Journal of Oral and Maxillofacial Surgery
Fadi Titinchi, Jean Morkel
PURPOSE: Ossifying fibroma (OF) is one of the most frequent of the 3 fibro-osseous lesions of the jaws and has had an inconstant recurrence rate. A definitive surgical protocol has not yet been published. The aim of the present study was to determine the clinical and radiologic features of OF at a tertiary hospital in South Africa, assess its management and recurrence patterns, and develop a surgical protocol. MATERIALS AND METHODS: A retrospective case-series analysis was performed of all histopathologically diagnosed OF cases from 1976 to 2014...
May 24, 2016: Journal of Oral and Maxillofacial Surgery
Yan Wang, Xuanping Huang, Feixin Liang, Nuo Zhou
We report on a case in which trifocal distraction osteogenesis was applied in a patient with a mandibular defect caused by resection of an ossifying fibroma. During the surgical procedure, we accidentally dissected the surrounding periosteal tissue of the left transport completely in the process of transport disc preparation and made the disc into a free bone graft. However, we still used this transport and successfully completed the distraction osteogenesis. The patient's facial and occlusal function were regained after treatment...
September 2016: Journal of Oral and Maxillofacial Surgery
Zhang Lina, Shen Ting, Niu Haoman, Geng Ning, Tang Yaling, Chen Yu
A case diagnosed as ossifying fibroma and compound odontoma in the mandible was reported. The clinicopathological features, diagnosis, and treatment were discussed with the literature review.
February 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
Hana Gadalla, Monica Lamble, Junu Ojha, Sohayla Mammo, Bassam Kinaia
No abstract text is available yet for this article.
April 2016: Journal of the Michigan Dental Association
(no author information available yet)
No abstract text is available yet for this article.
2016: BMJ Case Reports
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