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Ossifying fibroma

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https://www.readbyqxmd.com/read/29110035/-new-aspects-on-giant-cell-tumor-of-bone
#1
REVIEW
J Lüke, M Hasenfratz, P Möller, T F E Barth
A giant cell tumor of bone (GCTB) is one of the giant cell-rich lesions of bone and has to be differentiated from non-ossifying fibroma, aneurysmatic bone cyst, chondroblastoma, "brown tumor" and osteosarcoma containing giant cells. A hallmark of GCTB is the presence of the distinct histone 3 (H3F3A) mutation G34W and its detection either by sequencing methods or using immunohistochemistry with a novel antibody against this mutational site. Worrisome is the fact that under denosumab therapy a histological change of the lesions can be seen and there are first reports of sarcomas arising after therapy...
November 6, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29081852/the-aetiology-of-the-non-ossifying-fibroma-of-the-distal-femur-and-its-relationship-to-the-surrounding-soft-tissues
#2
A Goldin, D A Muzykewicz, J Dwek, S J Mubarak
PURPOSE: We aim to retrospectively evaluate patients with non-ossifying fibroma (NOF) of the distal femur by radiographs, CT and MRI, and to provide a theory describing the reasoning for the distal femur NOF's location and aetiology. METHODS: Charts of patients with NOFs between 2003 and 2014 were retrospectively reviewed. Inclusion criteria encompassed a diagnosis of NOF of the distal femur by imaging, and histologically, if available. Radiographs, CT and MRI were used to characterise the relationship of the NOF lesions with the surrounding soft tissues...
October 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29074442/conservative-management-of-an-atypical-intra-sinusal-ossifying-fibroma-associated-to-an-aneurysmal-bone-cyst
#3
R Saad, J-C Lutz, S Riehm, L Marcellin, C-I Gros, F Bornert
Ossifying fibroma (OF) is a benign fibro-osseous lesion mainly occurring in young adults and seems to originate from the periodontal ligament. Aneurysmal bone cyst (ABC) is a benign intraosseous lesion characterized by blood-filled spaces of various sizes. These two lesions can specifically affect the jaws and are commonly described in the literature. However, few cases describing an association of OF and ABC have been reported in the literature, especially in the maxillary sinus. We report the case of a 40-year-old male patient affected with an asymptomatic lesion with a dual component of OF and ABC laying in the maxillary sinus...
October 24, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29040582/cdc73-related-disorders-clinical-manifestations-and-case-detection-in-primary-hyperparathyroidism
#4
Karin van der Tuin, Carli M J Tops, Muriel A Adank, Jan-Maarten Cobben, Neveen A T Hamdy, Marjolijn C Jongmans, Fred H Menko, Bernadette P M van Nesselrooij, Romana T Netea-Maier, Jan C Oosterwijk, Gerlof D Valk, Bruce H R Wolffenbuttel, Frederik J Hes, Hans Morreau
Context: Heterozygous pathogenic germline variants in CDC73 predispose to the development of primary hyperparathyroidism (pHPT), and less frequently, ossifying fibroma of the jaw and renal and uterine tumors. Clinical information on CDC73-related disorders has so far been limited to small case series. Objective: To assess the clinical manifestations and penetrance in CDC73-related disorders and to improve case detection in pHPT. Design: Nationwide retrospective Dutch cohort study...
October 12, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29032608/microrna-profiling-reveals-dysregulated-micrornas-and-their-target-gene-regulatory-networks-in-cemento-ossifying-fibroma
#5
Thaís Dos Santos Fontes Pereira, João Artur Ricieri Brito, André Luiz Sena Guimarães, Carolina Cavaliéri Gomes, Júlio Cesar Tanos de Lacerda, Wagner Henriques de Castro, Roney Santos Coimbra, Marina Gonçalves Diniz, Ricardo Santiago Gomez
BACKGROUND: Cemento-ossifying fibroma (COF) is a benign fibro-osseous neoplasm of uncertain pathogenesis, and its treatment results in morbidity. MicroRNAs (miRNA) are small non-coding RNAs that regulate gene expression and may represent therapeutic targets. The purpose of the study was to generate a comprehensive miRNA profile of COF compared to normal bone. Additionally, the most relevant pathways and target genes of differentially expressed miRNA were investigated by in silico analysis...
October 15, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29027609/juvenile-trabecular-ossifying-fibroma
#6
Ahmed S Sultan, Michael K Schwartz, John F Caccamese, John C Papadimitriou, John Basile, Robert D Foss, Rania H Younis
Benign fibro-osseous lesions within the maxillofacial region represent a heterogeneous group of benign entities with overlapping histologic features. Ossifying fibroma, the rarest of these entities, represents a true neoplasm. Juvenile ossifying fibroma (JOF) is considered an aggressive rapidly growing sub-type. It tends to occur in the first or second decades of life. Based on histological and clinical features it can further be classified into two variants, namely juvenile trabecular ossifying fibroma (JTOF) and juvenile psammomatoid ossifying fibroma (JPOF)...
October 13, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28991228/deletion-of-menin-in-craniofacial-osteogenic-cells-in-mice-elicits-development-of-mandibular-ossifying-fibroma
#7
S Lee, P Liu, R Teinturier, J Jakob, M Tschaffon, A Tasdogan, R Wittig, S Hoeller, D Baumhoer, L Frappart, S Vettorazzi, P Bertolino, C Zhang, J Tuckermann
Ossifying fibroma (OF) is a rare benign tumor of the craniofacial bones that can reach considerable and disfiguring dimensions if left untreated. Although the clinicopathological characteristics of OF are well established, the underlying etiology has remained largely unknown. Our work indicates that Men1-a tumor suppressor gene responsible of Multiple endocrine neoplasia type 1-is critical for OF formation and shows that mice with targeted disruption of Men1 in osteoblasts (Men1(Runx2Cre)) develop multifocal OF in the mandible with a 100% penetrance...
October 9, 2017: Oncogene
https://www.readbyqxmd.com/read/28936339/utility-of-vs38c-in-the-diagnostic-and-prognostic-assessment-of-osteosarcoma-and-other-bone-tumours-tumour-like-lesions
#8
E S Hookway, Z Orosz, Y Uchihara, A Grigoriadis, A B Hassan, U Oppermann, N A Athanasou
BACKGROUND: VS38c is a monoclonal antibody that recognises a rough endoplasmic reticulum (rER) intracellular antigen termed cytoskeleton-linking membrane protein 63. rER is typically found in viable tumour cells and is abundant in osteosarcoma cells. The aim of this study was to determine the diagnostic and prognostic utility of VS38c in the histological assessment of osteosarcoma and other bone tumours/tumour-like leisons. METHODS: Immunohistochemical staining with VS38c was carried out on formalin-fixed specimens of osteosarcoma (pre/post-chemotherapy) and a wide range of benign and malignant bone lesions...
2017: Clinical Sarcoma Research
https://www.readbyqxmd.com/read/28932332/juvenile-psammomatoid-ossifying-fibroma-jpof-of-proximal-radius-a-rare-entity
#9
Jagadish Prabhu, Veena Nagaraj, Iftikhar Ahmed Mukhtar
BACKGROUND: Juvenile psammomatoid ossifying fibroma (JPOF) is a rare fibro-osseous lesion that usually occurs in the facial bones. The pathognomonic histopathologic feature is the presence of spherical ossicles, which are similar to psammoma bodies. It is considered to be a unique lesion because of its reported tendency to occur in children and adolescents and its tendency for locally aggressive growth. Because this lesion is aggressive in nature with high recurrence rate, early detection and complete surgical excision are essential...
2017: Open Orthopaedics Journal
https://www.readbyqxmd.com/read/28819829/surgical-treatment-for-symptomatic-non-ossifying-fibromas-of-the-lower-extremity-with-calcium-sulfate-grafts-in-skeletally-immature-patients
#10
Antonio Andreacchio, Flavia Alberghina, Gianluca Testa, Federico Canavese
BACKGROUND: Non-ossifying fibromas (NOFs) are common benign bone lesions found in children and adolescents. They usually involve metaphysis of long bones, tend to gradually disappear with age and usually do not require surgery, while they are not associated with pathological fractures. The aim of this study was to evaluate the outcome and efficacy of a single-stage procedure, comprising curettage of the lesion and calcium sulfate pellet (CaSP) grafting, in skeletally immature patients with large, symptomatic NOF of the lower extremity, and the possible limitations of the procedure...
August 17, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28808627/non-ossifying-fibromas-case-series-including-in-uncommon-upper-extremity-sites
#11
Akio Sakamoto, Ryuzo Arai, Takeshi Okamoto, Shuichi Matsuda
AIM: To investigate non-ossifying fibromas (NOFs) common fibrous bone lesions in children that occur in bones of the lower extremities. METHODS: We analyzed 44 cases of NOF including 47 lesions, which were referred with a working diagnosis of neoplastic lesions. Lesions were located in the upper extremities (1 proximal humerus, 1 distal radius) and the lower extremities (25 distal femurs, 12 proximal and 4 distal tibias, and 4 proximal fibulas). RESULTS: Three cases had NOFs in multiple anatomical locations (femur and fibula in 1 case, femur and tibia in 2 cases)...
July 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28797509/bone-related-lesions-of-the-jaws
#12
REVIEW
Daniel Baumhoer
The jaws combine several unique properties that mainly result from their distinct embryonic development and their role in providing anchorage for the teeth and their supporting structures. As a consequence, several bone-related lesions almost exclusively develop in the jaws (eg, osseous dysplasias, ossifying fibromas), have distinct clinical features (eg, osteosarcoma), or hardly ever occur at this location (eg, osteochondroma, enchondroma). The specific characteristics of these tumors and tumorlike lesions are outlined in this article...
September 2017: Surgical Pathology Clinics
https://www.readbyqxmd.com/read/28740329/940-nm-diode-laser-assisted-excision-of-peripheral-ossifying-fibroma-in-a-neonate
#13
Nitesh Tewari, Vijay Prakash Mathur, Asit Mridha, Kalpana Bansal, Divesh Sardana
BACKGROUND: Peripheral ossifying fibroma associated with neonatal tooth extraction is a rare, benign reactive lesion, but its nature and location often scares the patient & parents for possibility of neoplasm. A high recurrence rate makes its histopathological examination and long term follow up important. CASE REPORT: A 2 months old boy presented with enlarging soft tissue growth on the anterior mandibular ridge. The history revealed extraction of two neonatal teeth at 2 weeks of age...
March 31, 2017: Laser Therapy
https://www.readbyqxmd.com/read/28737157/oral-neoplasms-in-pickhandle-barracuda-sphyraena-jello-from-india
#14
V Singaravel, A Gopalakrishnan, K Raja, R Vijayakumar, S Asrafuzzaman
We report the spontaneous occurrence of oral neoplasms in pickhandle barracuda Sphyraena jello Cuvier, 1829 from Parangipettai, on the southeast coast of India. A total of 11736 fish were examined, of which 43 were affected with oral tumours, with an overall prevalence of 0.37%. Gross and clinical symptoms included reddish to grayish-white distended tumourous growths on the gingiva, intra-oral bones and tongue. The tumours exhibited delayed eruption and intra- or extra-oral swelling, varied in consistency from extremely firm to fleshy and released mucinous material...
July 24, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28678972/the-role-of-osterix-protein-in-the-pathogenesis-of-peripheral-ossifying-fibroma
#15
Vivian Narana Ribeiro El Achkar, Raphaella da Silveira Medeiros, Fernanda Gargano Longue, Ana Lia Anbinder, Estela Kaminagakura
Peripheral ossifying fibroma (POF) is a reactive lesion of oral tissues, associated with local factors such as trauma or presence of dental biofilm. POF treatment consists of curettage of the lesion combined with root scaling of adjacent teeth and/or removal of other sources of irritants. This study aimed to analyze the clinical and pathological features of POF and to investigate the immunoexpression of Osterix and STRO-1 proteins. Data such as age, gender, and size were obtained from 30 cases of POF. Microscopic features were assessed by conventional light microscopy using hematoxylin-eosin staining and immunohistochemical markers, and by polarized light microscopy using Picrosirius red staining...
July 3, 2017: Brazilian Oral Research
https://www.readbyqxmd.com/read/28674741/new-tumour-entities-in-the-4th-edition-of-the-world-health-organization-classification-of-head-and-neck-tumours-odontogenic-and-maxillofacial-bone-tumours
#16
REVIEW
Paul M Speight, Takashi Takata
The latest (4th) edition of the World Health Organization Classification of Head and Neck tumours has recently been published with a number of significant changes across all tumour sites. In particular, there has been a major attempt to simplify classifications and to use defining criteria which can be used globally in all situations, avoiding wherever possible the use of complex molecular techniques which may not be affordable or widely available. This review summarises the changes in Chapter 8: Odontogenic and maxillofacial bone lesions...
July 3, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28642188/costal-graft-as-a-support-for-bone-regeneration-after-mandibular-juvenile-ossifying-fibroma-resection-an-unusual-case-report
#17
F Fauvel, R Pace, F Grimaud, F Marion, P Corre, B Piot
Spontaneous regeneration of bone tissue after mandibular resection is rare in adults, although it does often take place in children. Periosteum conservation appears to play a major role in this healing process. We here report regarding a 5-year-old boy who exhibited a large mandibular trabecular juvenile ossifying fibroma. The lesion was treated by mandibulectomy, with careful preservation of the periosteal layer and immediate reconstruction with a costal graft by an intraoral approach. Monitoring over the course of a year revealed spontaneous mandibular regeneration, and it allowed for a series of measurements of the graft to be made...
June 19, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28588818/conglomeration-of-trabecular-and-psammomatoid-variants-of-juvenile-ossifying-fibroma-a-rare-case-report
#18
Lipsa Bhuyan, Abikshyeet Panda, Kailash Chandra Dash, Mohiddin S Gouse, Kiran Misra
Juvenile ossifying fibroma is an uncommon benign fibro-osseous lesion occurring in the craniofacial skeleton with a high recurrence rate. It has two distinct histopathologic variants: one trabecular and the other which are exclusive to each other. This case reveals a rare and unique combination of both the patterns in the same lesion.
June 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28566876/trabecular-variant-a-rare-entity-of-juvenile-ossifying-fibroma-of-the-mandible
#19
Pallavi Malaviya, Sandeep Choudhary, Sahil Gupta, O D Toshniwal
One of the rarest entities of fibro-osseous lesions that arise within the craniofacial bones is Juvenile ossifying fibroma (JOF). It is an intraosseous expansile lesion of the jaw that imitate odontogenic lesions. WHO has described two distinct histopathological variants of JOF; trabecular and psammomatoid. Histologically, they are characterized by the presence of fibrous connective tissue stroma along with osteoblastic and osteoclastic cells. Clinical, characteristics show an early age of onset, typical histological patterns, high rate of aggressive behavior and recurrence...
January 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/28491178/ossifying-fibroma-an-uncommon-differential-diagnosis-for-t2-hypointense-sinonasal-masses
#20
Andrea Carolina Inacio Salina, Pedro Mansueto Melo de Souza, Camila Maria da Costa Gadelha, Lindenberg Barbosa Aguiar, José Daniel Vieira de Castro, André Rodrigues Façanha Barreto
Ossifying fibroma is a benign fibro-osseous lesion that occurs most commonly in the mandible of female patients. In rare cases, it affects the nasal cavity. The magnetic resonance imaging features may vary depending on the amount of fibrous and bony tissue in its composition. In these tumors, T2-hypointensity is a feature described in the peripheral ossified areas of the lesion, but it may present diffusely, especially when the degree of ossification is extensive. In this scenario, this particular characteristic on T2-weighted imaging is superimposable to the commonly described appearance of other lesions, such as non-Hodgkin's lymphoma, melanoma, and other sinonasal neoplasms with high cellularity and high nucleocytoplasmic ratio...
June 2017: Radiology case reports
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