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Ossifying fibroma

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https://www.readbyqxmd.com/read/28211081/h3f3a-mutation-in-giant-cell-tumour-of-the-bone-is-detected-by-immunohistochemistry-using-a-monoclonal-antibody-against-the-g34w-mutated-site-of-the-histone-h3-3-variant
#1
Julian Lüke, Alexandra von Baer, Jordan Schreiber, Christoph Lübbehüsen, Thomas Breining, Kevin Mellert, Ralf Marienfeld, Markus Schultheiss, Peter Möller, Thomas Fe Barth
AIMS: Giant cell tumour of bone (GCTB) is a neoplasm predominantly of long bones characterised by the H3F3A mutation G34W. Conventional diagnostic is challenged by the tumour's giant cell-rich morphology, which overlaps with other giant cell containing lesions of the bone. Recently, a monoclonal antibody specific for the H3F3A mutation has been generated. Our aim was to test this antibody on a cohort of giant cell containing lesions. METHODS AND RESULTS: We used the antibody for analysis of 22 H3F3A-mutated GCTB, including two patients with recurrences; for comparison we analysed a cohort of 36 H3F3A-wild-type giant cell-rich lesions of the bone and soft tissue, containing one brown tumour, six aneurysmal bone cysts, six chondroblastomas, five non-ossifying-fibromas, two fibrous dysplasias, nine tenosynovial giant cell tumours, one giant cell-rich sarcoma and six osteosarcomas...
February 17, 2017: Histopathology
https://www.readbyqxmd.com/read/28210024/juvenile-trabecular-ossifying-fibroma-of-the-maxilla-a-case-report
#2
Samia Aboujaoude, Georges Aoun
INTRODUCTION: Juvenile ossifying fibromas are uncommon benign tumors. Their aggressiveness added to their high tendency to recur, provoke real diagnostic and therapeutic challenges for the dental practitioner and make a postoperative follow-up over the years indispensable. CASE REPORT: In this report, we present a case of a seven-year-old girl presented with a swelling in the face at the upper right maxillary region. After clinical, radiological, and histopathological examinations the diagnosis of trabecular juvenile ossifying fibroma was made...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28195085/histological-evaluation-of-the-possible-transformation-of-peripheral-giant-cell-granuloma-and-peripheral-ossifying-fibroma-a-preliminary-study
#3
Ömür Dereci, Şivge Akgün, Bülent Celasun, Adnan Öztürk, Ömer Günhan
AIMS: The objective of this study is to describe shared morphological features of peripheral giant cell granuloma (PGCG) and peripheral ossifying fibroma (POF) in detail and discuss the possible relationship between them. MATERIALS AND METHODS: Ten intermediate cases with features resembling to both POF and PGCG were selected and type 3 and 1 collagen immunostainings were performed for evaluation of the connective tissue maturation. Immunohistochemical staining percentage (SP) for stromal cells in the slides of POF and PGCG counterparts of intermediate lesions was scored as 1 when the SP was above 10%, 2 when the SP was above 25%, 3 when the SP was above 50% and 4 when the SP was above 75%...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28125310/juvenile-psammomatoid-ossifying-fibroma-in-paranasal-sinus-and-skull-base
#4
Mingjie Wang, Bing Zhou, Shunjiu Cui, Yunchuan Li
CONCLUSION: The endoscopic transnasal approach with IGS is a safe and effective technique, allowing completely resection of JPOF, with minimal morbidity and recurrence. OBJECTIVES: JPOF is a benign but locally aggressive fibro-osseous lesion. This study presents a series of JPOF cases, involving anterior skull base and orbit, treated by endoscopic transnasal approach with image guidance system (IGS) to resect the mass completely. METHOD: This study retrospectively reviewed the clinical presentations, surgical procedures, and complications of 11 patients with JPOF who were treated by endoscopic approach from May 2009 to April 2014...
January 26, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28125308/endoscopic-resection-of-ossifying-fibroma-involving-paranasal-sinuses-and-the-skull-base-in-a-series-of-15-cases
#5
Ping Ye, Qian Huang, Bing Zhou
CONCLUSION: The key technical challenges in the resection of OFs are rapid removal of tumors by image-guided navigation, determining the boundary of the resection and the proper control of blood supply through the anterior or posterior ethmoidal arteries. OBJECTIVE: This study aimed to analyze the clinical data of adult patients with paranasal ossifying fibromas involving the anterior skull base and orbit. The surgical technique and indications are also discussed...
January 26, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28119439/successful-treatment-of-tumour-induced-osteomalacia-after-resection-of-an-oral-peripheral-ossifying-fibroma
#6
Mark Anthony Santiago Sandoval, Majorie Amoroto Palermo, Ryner Carrillo, Rafael Bundoc, Jose Ma Carnate, Romelito Jose Galsim
Tumour-induced osteomalacia is a paraneoplastic syndrome wherein bone is affected by a hormone from a tumour that causes renal phosphate wasting and hypophosphataemia. Here, we present the case of a 31-year-old man who has been suffering from generalised bone pains and a spine deformity that led to loss of height. Pertinent findings are low serum phosphorus, low vitamin D and decreased bone mineral density. These findings led to a diagnosis of osteomalacia. However, the finding of an oral mass raised some questions as to what role it plays in the patient's disease...
January 24, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28111211/the-drawer-like-resection-and-reconstruction-with-titanium-mesh-a-novel-surgical-technique-for-treatment-of-giant-ossifying-fibroma-in-the-maxilla
#7
Mingming Lv, Jun Li, Yi Shen, Liang Wang, Jian Sun
PURPOSE: The aim of this article is to introduce a new surgical method for the treatment of ossifying fibroma (OF) in the maxilla with dislocation of the eyeball and to evaluate the postoperative outcomes and prognosis. PATIENTS AND METHODS: Cases of maxillary OF treated with "drawer-like" resection from 2014 to 2015 were reviewed. The surgical procedure consisted of total removal of the orbital floor and most of the maxilla with preservation of the alveolar ridge immediately followed by reconstruction with titanium mesh...
December 29, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27998739/can-differences-in-vascularity-serve-as-a-diagnostic-aid-in-fibro-osseous-lesions-of-the-jaws
#8
Tom Shmuly, Dror M Allon, Marilena Vered, Gavriel Chaushu, Benjamin Shlomi, Ilana Kaplan
PURPOSE: Different lesions in the fibro-osseous group share microscopic features; thus, establishing a definitive diagnosis based on microscopic features alone can be a challenge. There is a need for additional microscopic tools to aid in differentiating these lesions. This study compared parameters related to vascularity among 3 lesions in the fibro-osseous group: fibrous dysplasia (FD), central ossifying fibroma (COF), and cemento-osseous dysplasia (COD). MATERIALS AND METHODS: This study was a cross-sectional analysis of biopsied lesions retrieved from 3 medical centers over a 14-year period...
November 24, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27922957/ossifying-fibroma-involving-three-quadrants-of-the-jaws-in-a-patient-with-vitamin-d-deficiency
#9
Adnan Kilinç, Tahsin Tepecik, Ertunç Dayi, Betül Gündoğdu
No abstract text is available yet for this article.
December 5, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27891263/coverage-root-after-removing-peripheral-ossifying-fibroma-5-year-follow-up-case-report
#10
Paulo S G Henriques, Luciana S Okajima, Marcelo P Nunes, Victor A M Montalli
When lesions in soft tissue reach the gingival margin, they can produce aesthetic defects during its permanence and after its removal. Periodontal plastic surgery allows the correction of the gingival contour using different techniques. This paper is a case report of a peripheral ossifying fibroma removal in the interproximal area of teeth 21 and 22 in addition to root coverage of the affected area through two surgical phases: keratinized gingival tissue augmentation surgery with free gingival graft concurrent with removal of the lesion and, in a second stage, root coverage by performing coronally advanced flap technique with a follow-up of five years...
2016: Case Reports in Dentistry
https://www.readbyqxmd.com/read/27831973/conservative-management-of-central-cemento-ossifying-fibroma
#11
Pedro Henrique Silva Gomes-Ferreira, Leandro Carlos Carrasco, Danila de Oliveira, Járede Carvalho Pereira, Luis Fernando Azambuja Alcalde, Leonardo Perez Faverani
Central cemento-ossifying fibroma is characterized by the combined production of osteoid and cementoid tissue. Radiographically, this lesion is presented as an outlined cortical and variable radiopaque spots, also can be present complete radiolucent or different degrees of radiopacity. The recommended treatment is curettage or enucleation, and the recurrence rate is less than 5%. Considering that surgical treatment is invasive, mainly in large lesions, this study aims to report a patient in whom conservative treatment was carried out by involving the preservation of teeth, with a long-term follow-up...
January 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27826699/a-unique-case-of-multiple-non-ossifying-fibromas-with-polyostotic-monomelic-distribution-and-aggressive-clinical-course
#12
Alessandro Corsi, Cristina Remoli, Mara Riminucci, Ernesto Ippolito, John Dimitriou
Multiple non-ossifying fibromas (MNOFs) occur either isolated or in association with other anomalies, are usually localized in the long bones of the lower limbs, may be radiographically confused with other skeletal lesions, and tend to heal spontaneously with the completion of the skeletal growth. Segmental distribution, either monomelic or polymelic and ipsilateral, is rare and commonly observed in the context of developmental diseases known as "RASopathies", which are caused by mutations in genes that encode components or regulators within the Ras/mitogen-activated protein kinase signaling pathway...
February 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/27822773/erratum-to-an-update-on-peripheral-ossifying-fibroma-case-report-and-literature-review
#13
María José Franco-Barrera, María Guadalupe Zavala-Cerna, Rubén Fernández-Tamayo, Israel Vivanco-Pérez, Nora Mariana Fernández-Tamayo, Olivia Torres-Bugarín
No abstract text is available yet for this article.
November 8, 2016: Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27800197/a-swelling-in-the-mouth-in-a-chronic-hemodialysis-patient
#14
Arnaud Devresse, Alexandros Raptis, Anne-Sophie Claes, Laura Labriola
Oral manifestations of severe secondary hyperparathyroidism include maxillary and mandibular deformities, brown tumors, dental abnormalities, and metastatic calcification of soft tissues. We report on a chronic hemodialysis (HD) woman with severe, uncontrolled secondary hyperparathyroidism and a painful, nontender mass in the floor of her mouth. The most likely clinical diagnosis was a bone tumoral lesion of the oral cavity, secondary to renal osteodystrophy. Unexpectedly, pathological examination showed characteristic features of ossifying fibroma (OF) of the jaw, a rare, benign fibroosseous lesion characterized by the replacement of normal bone by collagen and fibroblasts containing varying amounts of mineralized substance...
2016: Case Reports in Nephrology
https://www.readbyqxmd.com/read/27797795/cemento-ossifying-fibroma-of-mandible-mimicking-complex-composite-odontome
#15
Hitesh Sudarshan Dewan, Sudarshan Kumar Dewan, Sumit Bahl, Parth Tushar Parekh
Cemento-ossifying fibroma (COF) is a fibro-osseous lesion or non-odontogenic tumour that affects craniofacial bones. These lesions are included in the spectrum of fibro-osseous lesions arising from periodontal ligament cells, which can deposit combination of cementum and bone surrounded by fibrous tissue. It clinically, macroscopically and radiologically resembles complex composite odontome and can be differentiated only on the basis of histopathology. They usually occur solitarily as a painless and expansile spherical or ovoid jawbone mass that may displace the roots of adjacent teeth...
October 19, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27795650/peripheral-ossifying-fibroma-a-rare-case-affecting-maxillary-region
#16
Sahana Ashok, Anish Ashok Gupta, K P Ashok, Shubhangi Ashok Mhaske
Focal gingival enlargements are a diverse group of lesions with almost similar clinical presentation but varied etiology and histopathology. The actual cause of peripheral ossifying fibroma (POF) has been debated over many years. POFs are usually seen in childhood and younger ages. There is a slight female predilection. It is usually localized, rarely generalized. Usually, the treatment option is only surgical excision with minimal chances of recurrence. Here, we report a case of POF of the right maxillary posterior region with a review of literature...
September 2016: Indian Journal of Dentistry
https://www.readbyqxmd.com/read/27679651/recurrence-of-hyperparathyroid-hypercalcemia-in-a-patient-with-the-hrpt-2-mutation-and-a-previous-parathyroid-carcinoma-in-hyperparathyroidism-jaw-tumor-syndrome
#17
Marco Mele, Lars Rolighed, MarieLouise Jespersen, Lars Rejnmark, Peer Christiansen
INTRODUCTION: Cancer in the parathyroid gland is rare, but parathyroid cancer is occasionally seen in relation to genetic abnormalities. Due to a limited amount of evidence, the optimal handling of these cases is not clear. Furthermore, the presence of a malignant parathyroid tumor is rarely known at the time of the initial operation; therefore, re-operations are often necessary. The aim of this study was to present the case of a patient with a previously diagnosed jaw tumor and parathyroid carcinoma that presents as a recurrence of hyperparathyroid hypercalcemia...
April 2016: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27658992/cdc73-gene-mutations-in-sporadic-ossifying-fibroma-of-the-jaws
#18
Yan Chen, Da-Yan Hu, Ting-Ting Wang, Ran Zhang, Qing Dong, Zhi-Xiu Xu, Lin Wang, Tie-Jun Li
BACKGROUND: The tumor suppressor gene CDC73 was found to be associated with hyperparathyroidism-jaw tumor syndrome (HPT-JT), which is characterized by parathyroid adenoma or carcinoma, ossifying fibroma (OF) of the jaws, and renal and uterine lesions. Mutations in CDC73 have also been frequently detected in sporadic parathyroid carcinomas and renal tumors. However, the prevalence and range of CDC73 mutations in sporadic OFs have not been established. METHODS: We directly sequenced coding and flanking splice junctional regions of CDC73 in 40 cases of sporadic OF of the jaws...
2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27651062/hyperparathyroidism-jaw-tumour-syndrome-a-pictoral-review
#19
REVIEW
Hannah du Preez, Ashok Adams, Polly Richards, Simon Whitley
: Hyperparathyroidism jaw tumour syndrome is a rare autosomal dominant inherited endocrine neoplasia syndrome, which predisposes carriers to develop a triad of multiple ossifying fibromas of the maxilla and mandible, parathyroid adenomas and carcinomas (with consequent hyperparathyroidism) as well as renal and uterine tumours. The prevalence of this condition is unknown. Patients typically present initially with symptoms and signs of a jaw tumour. A high index of suspicion is required for the underlying diagnosis to be recognised, enabling appropriate management of jaw lesions, treatment of hyperparathyroidism, if present, as well as early detection of malignant disease and screening of family members...
December 2016: Insights Into Imaging
https://www.readbyqxmd.com/read/27650236/hyperparathyroidism-jaw-tumor-syndrome-an-overlooked-cause-of-severe-hypercalcemia
#20
Joseph Wolfgang Mathews, Rhonda Winchester, Nebras Alsaygh, Anne M Bartlett, Louis Luttrell
Ossifying fibromas of the maxillofacial bones are an uncommon form of benign neoplasm usually treated by surgical excision. Up to 30% of patients with hyperparathyroidism-jaw tumor syndrome, a rare form of multiple endocrine neoplasia resulting from autosomal dominant inactivating mutation of the Hrpt2 tumor suppressor gene, initially present with ossifying fibromas. Coincident hypercalcemia because of the presence of parathyroid adenoma is common in these patients, of whom 15% may have or may develop parathyroid carcinoma...
September 2016: American Journal of the Medical Sciences
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