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Cutaneous Surgery

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https://www.readbyqxmd.com/read/28746702/identifying-an-optimal-adjuvant-radiotherapy-dose-for-extremity-and-trunk-merkel-cell-carcinoma-following-resection-an-analysis-of-the-national-cancer-database
#1
Sagar A Patel, Muhammad M Qureshi, Debjani Sahni, Minh Tam Truong
Importance: Merkel cell carcinoma (MCC) is a rare and aggressive cutaneous neuroendocrine neoplasm with a high risk of recurrence following resection. Despite a rising incidence over the past 3 decades, there is a paucity of prospective data owing to the rarity of this disease. Objective: To determine the optimal adjuvant radiation therapy (RT) dose following resection of localized MCC of the extremities or trunk. Design, Setting, and Participants: Using the National Cancer Database, a large national database consisting of a heterogeneous population and treatment settings, we retrospectively analyzed a cohort of 2093 patients 18 years or older with stage I to III MCC of the extremities and/or trunk treated with definitive surgery and adjuvant RT between 1998 and 2011...
July 26, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28745581/clinical-correlates-and-prognostic-value-of-different-metastatic-sites-in-patients-with-malignant-melanoma-of-the-skin-a-seer-database-analysis
#2
Omar Abdel-Rahman
BACKGROUND: Population-based data on the clinical correlates and prognostic value of the pattern of metastases among patients with cutaneous melanoma are needed. METHODS: Surveillance, Epidemiology and End Results (SEER) database (2010-2013) has been explored through SEER*Stat program. For each of six distant metastatic sites (bone, brain, liver, lung, distant lymph nodes, skin/subcutaneous), relevant correlation with baseline characteristics were reported. Survival analysis has been conducted through Kaplan-Meier analysis and multivariate analysis has been conducted through a Cox proportional hazard model...
July 26, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28745437/vascularized-ulnar-periosteal-pedicled-flap-for-forearm-reconstruction-anatomical-study-and-a-case-report
#3
Barrera-Ochoa Sergi, Velez Roberto, Rodriguez-Baeza Alfonso, De Bergua-Domingo Josep Maria, Knörr Jorge, Soldado Francisco
PURPOSE: Through an anatomical review, the aim of this study is to define the ulnar periosteal branches of the posterior interosseous vessels (PIV). In addition, we report the clinical utility of a vascularized ulnar periosteal pedicled flap (VUPPF), supplied by the investigated PIV, in a complex case of radial nonunion. METHODS: Ten upper limbs latex colored from fresh human cadavers were used. Branches of the PIV were dissected under 2.5× loupe magnification, noting the periosteal, muscular, and cutaneous branches arising distal to the interosseous recurrent artery...
July 26, 2017: Microsurgery
https://www.readbyqxmd.com/read/28736885/cutaneous-squamous-cell-carcinoma-of-the-scalp-extending-to-the-skull-a-case-report-and-review-of-the-literature
#4
Marc Z Handler, David J Goldberg
Squamous cell carcinoma (SCC) of the scalp has increased prevalence in older patients and often presents later in life. Mohs micrographic surgery remains the most effective treatment in most cases. Delayed presentation may result in localized bony invasion or distant metastases. We present a case of an elderly woman presenting with extension of SCC into the parietal bone of the skull.
July 23, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28736231/serial-or-parallel-metastasis-of-cutaneous-melanoma-a-study-of-the-german-central-malignant-melanoma-registry
#5
Maximilian Gassenmaier, Thomas Kurt Eigentler, Ulrike Keim, Matthias Goebeler, Eckhard Fiedler, Gerold Schuler, Ulrike Leiter, Benjamin Weide, Eva-Maria Grischke, Peter Martus, Claus Garbe
For more than a century the Halstedian hypothesis of contiguous metastasis from the primary tumor through the lymphatics to distant sites shaped the lymph node surgery for melanoma. We challenge this dogma of serial metastatic dissemination. A single-center series of 2299 patients with cutaneous metastatic melanoma was investigated to analyze overall survival (OS) and distant metastasis-free survival (DMFS) of stage IV patients with or without primary lymphatic metastasis. Results were then compared with those of 2134 patients from three independent centers of the German Central Malignant Melanoma Registry...
July 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28736229/survival-of-patients-with-cutaneous-squamous-cell-carcinoma-results-of-a-prospective-cohort-study
#6
Thomas K Eigentler, Ulrike Leiter, Hans-Martin Häfner, Claus Garbe, Martin Röcken, Helmut Breuninger
Cutaneous squamous cell carcinoma (cSCC) is an increasing health burden in Caucasian populations. We prospectively assessed risk factors for tumour-specific and overall survival in 1434 patients who underwent surgery for cSCC between Jan 24, 2005, and May 29, 2015. A total of 2149 invasive cSCCs were analysed. Univariate and multivariate survival analyses included tumour thickness, horizontal size, body site, histological differentiation, desmoplastic growth, history of multiple cSCC, and immunosuppression...
July 20, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28734080/transumbilical-laparoendoscopic-single-site-radical-prostatectomy-and-cystectomy-with-the-aid-of-transurethral-port-a-feasibility-study
#7
Jian Su, Qingyi Zhu, Lin Yuan, Yang Zhang, Qingling Zhang, Yunfei Wei
OBJECTIVE: Our aim was to describe the surgical technique and report early outcomes of transurethral assisted laparoendoscopic single-site radical prostatectomy (LESS-RP) and cystectomy (LESS-RC) in a single institution. MATERIALS AND METHODS: Between December 2014 and March 2016, 114 cases were performed LESS-RP and LESS-RC, including LESS-RP (n=68), LESS-RC with cutaneous ureterostomy (LESS-RC/CU) (n=38) and LESS-RC with orthotopic ileal neobladder (LESS-RC/OIN) (n=8)...
July 22, 2017: BJU International
https://www.readbyqxmd.com/read/28725431/angiosarcoma-treated-successfully-with-anti-pd-1-therapy-a-case-report
#8
Simran Sindhu, Lana H Gimber, Lee Cranmer, Ali McBride, Andrew S Kraft
BACKGROUND: Angiosarcomas are tumors of malignant endothelial origin that have a poor prognosis with a five-year survival of less than 40%. These tumors can be found in all age groups, but are more common in older patients; with the cutaneous form most common in older white men. Combined modality therapy including surgery and radiation appears to have a better outcome than each modality alone. When metastatic, agents such as liposomal doxorubicin, paclitaxel and ifosfamide have activity but it is short-lived and not curative...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28725269/musculoskeletal-echinococcus-infection-as-a-rare-first-presentation-of-hydatid-disease-case-report
#9
A Marzouki, A Naam, S Abdulrazak, B Soumaré, K Lahrach, F Boutayeb
BACKGROUND: Hydatid disease (HD) is a cosmopolitan parasitosis caused by Echinococcus granulosus that can potentially affect any part of the human body. Liver and lungs are the most frequent localizations. Primary musculoskeletal hydatidosis are seldom reported in literature and their incidence is unknown. CASE PRESENTATION: We deem interesting to report a case of a primary hydatid cyst in a 25-year-old patient who presented with a painful swelling of the right elbow...
2017: Patient Safety in Surgery
https://www.readbyqxmd.com/read/28719713/lymph-node-positive-cutaneous-nonmelanoma-skin-cancer-a-poor-prognosis-disease-in-need-of-treatment-intensification
#10
Lora S Wang, Elizabeth A Handorf, John A Ridge, Barbara A Burtness, Miriam N Lango, Ranee Mehra, Jeffrey C Liu, Thomas J Galloway
Locoregionally advanced nonmelanoma skin cancer (NMSC) has an aggressive clinical course characterized by high rates of treatment failure and poor survival compared with localized skin cancers. Our goal was to investigate multimodal therapy for lymph-node-positive NMSC. Data from patients with lymph-node-positive NMSC who underwent surgery and adjuvant therapy at a single tertiary center from 2002 to 2012 were retrospectively reviewed. Median follow-up was 1.8 years (range: 0.5 to 8.5). Overall survival (OS) and progression-free survival (PFS) were calculated using the Kaplan-Meier method...
July 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28716069/angiosarcoma-treated-successfully-with-anti-pd-1-therapy-a-case-report
#11
Simran Sindhu, Lana H Gimber, Lee Cranmer, Ali McBride, Andrew S Kraft
BACKGROUND: Angiosarcomas are tumors of malignant endothelial origin that have a poor prognosis with a five-year survival of less than 40%. These tumors can be found in all age groups, but are more common in older patients; with the cutaneous form most common in older white men. Combined modality therapy including surgery and radiation appears to have a better outcome than each modality alone. When metastatic, agents such as liposomal doxorubicin, paclitaxel and ifosfamide have activity but it is short-lived and not curative...
July 18, 2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28714784/the-management-of-paediatric-neurogenic-bladder-an-approach-in-a-resource-poor-setting
#12
Patrick Opoku Manu Maison, John Lazarus
BACKGROUND: If untreated, paediatric neurogenic bladder can cause renal failure and urinary incontinence. It is usually caused by neural tube defects such as myelomeningocele. Children with a neurogenic bladder should be monitored from birth and management should aim to preserve renal function and achieve social continence. This article outlines the management options appropriate for these children in resource-poor settings. ASSESSMENT: In most low- and middle-income countries, a general lack of awareness of the neurological effects on the urinary tract results in late presentation, usually with urological complications even when spina bifida is diagnosed early...
July 17, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28712323/management-of-cutaneous-merkel-cell-carcinoma
#13
William M Mendenhall, Christopher G Morris, Jessica M Kirwan, Robert J Amdur, Christiana Shaw, Peter T Dziegielewski
PURPOSE: To report the outcomes of patients with previously untreated cutaneous Merkel cell carcinoma (MCC) managed with curative intent. MATERIAL AND METHODS: Between December 1984 and August 2015, 59 patients with previously untreated cutaneous MCC were managed with curative intent with surgery and adjuvant radiotherapy (54 patients) or radiotherapy alone (5 patients) at the University of Florida. Primary sites included head and neck (45 patients), extremities (11 patients) and trunk (3 patients)...
July 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28710797/surgical-treatment-associated-with-improved-survival-in-patients-with-cutaneous-angiosarcoma
#14
O Trofymenko, C Curiel-Lewandrowski
Cutaneous angiosarcoma is a rare aggressive vasoformative neoplasm of the skin with a poor prognosis.(1) The neoplasm preferentially involves areas of head and neck and usually diagnosed in advanced stage.(1, 2) The neoplasm accounts for only 2% of soft-tissue sarcomas in the U.S. and most often affects elderly white males, patients treated with radiation, and individuals with certain chronic lymphatic disorders.(3) Surgery with or without adjuvant or neoadjuvant radiation therapy (RT) is considered the mainstay of therapy...
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28702986/electromagnetic-field-in-control-tissue-regeneration-pelvic-pain-neuro-inflammation-and-modulation-of-non-neuronal-cells
#15
S E Aragona, G Mereghetti, G Gianazza, A Salsa, G Gianazza, J Lotti, A Vosa, T Lotti, E Canavesi
In scientific literature, magnetic fields are used both in basic science and clinical research. They are often used to treat pain and neuro-inflammation disorders thanks to their influence on cellular responses. Our project was born from the regenerative support that we wanted to give to those diseases characterized by neuro-inflammation, nerve lesion, muscles and tissues disorders that can transform the symptom (e.g. neuropathic pelvic pain) in disease. In this study, we examined the action of pulsed electromagnetic fields (PEMFs) on skin lesion regeneration and the repetitive trans-pelvic magnetic stimulation (rTPMS) on patients affected by incontinence and post-surgical problems, sexual dysfunction, and pelvic pain...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28700792/association-of-ibrutinib-treatment-with-bleeding-complications-in-cutaneous-surgery
#16
Cindy E Parra, Emily Newsom, Erica H Lee, John N Allan, Kira Minkis
No abstract text is available yet for this article.
July 12, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28698757/new-safety-margins-for-melanoma-surgery-nice-possibility-for-drinking-of-just-that-cup-of-coffee
#17
Georgi Tchernev, Anastasiya Atanasova Chokoeva
BACKGROUND: The American Joint Committee on Cancer (AJCC's) skin melanoma surgical treatment recommendations from 2011 are characterised by a prima facie "freedom of choice" regarding how extensive should be the excisions for melanomas with tumour thickness up to 2 mm and melanoma in situ. It is unclear why the recommended surgical security margins vary between 0.5 and 1 cm for melanoma in situ, whereas for melanomas with a tumour thickness of up to 1.99 mm, the range of variation is also between 1 and 2 cm, without specifying when the surgical field should be broader and, narrower, accordingly...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28697227/postoperative-pyoderma-gangrenosum-following-video-assisted-thoracic-surgery
#18
Stanislav N Tolkachjov, Philip Y Sun, Alina G Bridges
<p>Pyoderma gangrenosum (PG) is a neutrophilic, ulcerative dermatosis that can develop at sites of cutaneous trauma, including surgical incisions, a phenomenon known as pathergy. The characteristic lesion is a painful, rapidly expanding ulceration with a violaceous undermined border.<sup>1</sup> A biopsy taken from the expanding violaceous border shows predominantly neutrophilic dermal inflammation with neutrophilic abscess formation.</p> <p>The etiology of PG appears to be variable among patients, as about a half of the reported cases are associated with systemic disease such as inflammatory bowel disease, rheumatoid arthritis, or myeloproliferative disorders, while the other half seem to be idiopathic...
July 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28696382/phosphoinositide-3-kinase-dependent-signalling-pathways-in-cutaneous-squamous-cell-carcinomas
#19
REVIEW
Joanna M Janus, Ryan F L O'Shaughnessy, Catherine A Harwood, Tania Maffucci
Cutaneous squamous cell carcinoma (cSCC) derives from keratinocytes in the epidermis and accounts for 15-20% of all cutaneous malignancies. Although it is usually curable by surgery, 5% of these tumours metastasise leading to poor prognosis mostly because of a lack of therapies and validated biomarkers. As the incidence rate is rising worldwide it has become increasingly important to better understand the mechanisms involved in cSCC development and progression in order to develop therapeutic strategies. Here we discuss some of the evidence indicating that activation of phosphoinositide 3-kinases (PI3Ks)-dependent signalling pathways (in particular the PI3Ks targets Akt and mTOR) has a key role in cSCC...
July 11, 2017: Cancers
https://www.readbyqxmd.com/read/28688695/transoral-thyroidectomy-and-parathyroidectomy-a-north-american-series-of-robotic-and-endoscopic-transoral-approaches-to-the-central-neck
#20
Jonathon O Russell, James Clark, Salem I Noureldine, Angkoon Anuwong, Mai G Al Khadem, Hoon Yub Kim, Vaninder K Dhillon, Gianlorenzo Dionigi, Ralph P Tufano, Jeremy D Richmon
OBJECTIVE: Most thyroid surgery in North America is completed via a cervical incision, which leaves a permanent scar. Approaches without cutaneous incisions offer aesthetic advantages. This series represents the largest series of transoral vestibular approaches to the central neck in North America, and the first published reports of robotic transoral vestibular thyroidectomy for thyroid carcinoma. MATERIALS AND METHODS: Data was prospectively collected for patients that underwent transoral vestibular approach thyroidectomy and/or parathyroidectomy between April 2016 and February 2017...
August 2017: Oral Oncology
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