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Osteofibrous dysplasia

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https://www.readbyqxmd.com/read/27745864/long-term-outcome-following-treatment-of-adamantinoma-and-osteofibrous-dysplasia-of-long-bones
#1
S E Puchner, R Varga, G M Hobusch, M Kasparek, J Panotopoulos, S Lang, R Windhager, P T Funovics
INTRODUCTION: Adamantinoma (AD) is an ultimately rare, low-grade malignant bone tumor. In most cases it occurs in the tibia of young adults. Osteofibrous dysplasia (OFD) is a rare, benign, lesion that is typically seen in children. Histopathology, ultrastructure, and cytogenetics indicate that these lesions are closely related. Yet, etiology remains a matter of debate. Local recurrence rates are high for both entities as published in literature and long-term outcomes are scarce, due to the rarity of the disease...
October 10, 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/27534092/-osteofibrous-dysplasia-of-metacarpus-a-case-report
#2
Wen-jiang Duan, Jian-min Chen, Zhi-chang Zhang, Yang Dong
No abstract text is available yet for this article.
June 2016: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/27413281/osteofibrous-dysplasia-of-clavicle-clinically-mimicking-chronic-osteomyelitis
#3
Nirmal Raj Gopinathan, Mahesh Prakash, Balaji Saibaba, Ashim Das
Osteofibrous dysplasia or ossifying fibroma is an uncommon benign fibro-osseous lesion of childhood, commonly described in the maxilla and the mandible. Among long bones, it usually presents in the tibia as a painless swelling or anterior bowing. Ossifying fibroma of clavicle has never been reported in English literature, to the best of our knowledge. Here, we would like to present an unusual case of osteofibrous dysplasia of clavicle clinically mimicking chronic osteomyelitis.
April 2016: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/27216410/-tumor-like-lesions-of-bone
#4
R Erlemann, G Jundt
Historically, tumor-like lesions of bone were defined as non-neoplastic bone lesions. Today, however, some of them are considered real neoplasms. They are among the most frequent bone lesions. They usually grow slowly, but occasionally they grow rapidly. Many of them can be diagnosed by plain films alone; in others, CT and MRI yield additional features for a correct diagnosis. Some lesions do not need treatment; others should be resected, and some may even recur. Non-ossifying fibroma, juvenile and aneurysmal bone cysts, fibrous and osteofibrous dysplasia and eosinophilic granuloma are presented...
June 2016: Der Radiologe
https://www.readbyqxmd.com/read/26788171/chondroblastic-osteosarcoma-secondary-to-fibrosarcoma-a-case-report-and-literature-review
#5
Yi-Fei Zheng, Jun Lin, Hui-Lin Yang
Osteosarcoma, which is most common in non-blood systemic tumors, accounts for 20% of primary bone malignancies. Primary osteosarcoma usually occurs in young individuals aged 10-20 years, while secondary osteosarcoma is more common in the elderly. It had been reported that secondary osteosarcoma may be associated with osteofibrous dysplasia, bone infarction, chondrosarcoma or osteogenesis imperfecta. However, osteosarcoma secondary to fibrosarcoma has rarely been reported. The current study presents the rare case of a female with chondroblastic osteosarcoma secondary to fibrosarcoma...
December 2015: Oncology Letters
https://www.readbyqxmd.com/read/26637977/mutations-preventing-regulated-exon-skipping-in-met-cause-osteofibrous-dysplasia
#6
Mary J Gray, Peter Kannu, Swarkar Sharma, Christine Neyt, Dongping Zhang, Nandina Paria, Philip B Daniel, Heather Whetstone, Hans-Georg Sprenger, Philipp Hammerschmidt, Angela Weng, Lucie Dupuis, Rebekah Jobling, Roberto Mendoza-Londono, Michael Dray, Peiqiang Su, Megan J Wilson, Raj P Kapur, Edward F McCarthy, Benjamin A Alman, Andrew Howard, Gino R Somers, Christian R Marshall, Simon Manners, Adrienne M Flanagan, Karl E Rathjen, Lori A Karol, Haemish Crawford, David M Markie, Jonathan J Rios, Carol A Wise, Stephen P Robertson
The periosteum contributes to bone repair and maintenance of cortical bone mass. In contrast to the understanding of bone development within the epiphyseal growth plate, factors that regulate periosteal osteogenesis have not been studied as intensively. Osteofibrous dysplasia (OFD) is a congenital disorder of osteogenesis and is typically sporadic and characterized by radiolucent lesions affecting the cortical bone immediately under the periosteum of the tibia and fibula. We identified germline mutations in MET, encoding a receptor tyrosine kinase, that segregate with an autosomal-dominant form of OFD in three families and a mutation in a fourth affected subject from a simplex family and with bilateral disease...
December 3, 2015: American Journal of Human Genetics
https://www.readbyqxmd.com/read/26599503/autologous-mesenchymal-stem-cell-mscs-transplantation-for-critical-sized-bone-defect-following-a-wide-excision-of-osteofibrous-dysplasia
#7
Ismail Hadisoebroto Dilogo, Achmad Fauzi Kamal, Bambang Gunawan, Rangga Valentino Rawung
INTRODUCTION: Osteofibrous dysplasia is a rare non-neoplastic disease that is almost exclusive to pediatric tibial diaphysis. Wide excision of the lesion is recommended to avoid recurrence. However, such radical surgery will results in large segmental bone defects that will require further extensive reconstructive surgery. We report a novel approach of treating bone defect by implementing the diamond concept of bone healing using autologous bone marrow derived mesenchymal stem cells (BM-MSCs)...
2015: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/26447423/osteofibrous-dysplasia-like-adamantinoma-of-the-tibia-in-a-15-year-old-girl
#8
Atul Ratra, Adam Wooldridge, George Brindley
Osteofibrous dysplasia and adamantinoma are rare lesions of primary benign and malignant bone tumors with an incidence of less than 1%. These lesions arise primarily in long bones with a predilection for the tibia and fibula. Osteofibrous dysplasia is a benign fibro-osseous lesion typically found in children younger than 10 years. Adamantinomas, however, are highly malignant and invasive tumors found predominantly in adult men, with an average age of diagnosis between 20 and 50 years. Debate continues on whether osteofibrous dysplasia and adamantinoma occupy the same disease spectrum...
October 2015: American Journal of Orthopedics
https://www.readbyqxmd.com/read/26217473/bone-transport-for-reconstruction-in-benign-bone-tumors
#9
Chang Seon Oh, Sung Taek Jung, Yong Jin Cho, Yeong Seub Ahn, Bo Ram Na
BACKGROUND: The aim of this study was to assess the results of using the Ilizarov apparatus to transport bones in the treatment of benign bone tumors. METHODS: Seven patients (six males and one female) with benign bone tumors were treated by bone transport with an Ilizarov apparatus at our institution. Their mean age at surgery was 14.4 years (range, 4.8 to 36.9 years). The histological diagnoses were osteofibrous dysplasia (4), giant-cell tumor (1), intraosseous cavernous hemangioma (1), and aneurysmal bone cyst (1)...
June 2015: Clinics in Orthopedic Surgery
https://www.readbyqxmd.com/read/26012944/osteofibrous-dysplasia-like-adamantinoma-in-a-3-month-old-male-infant-a-case-report
#10
Halil Buldu, Tuncay Centel, Hale Kırımlıoğlu, Yalın Dirik
We report a case of a very rarely seen osteofibrous dysplasia-like adamantinoma (OFDLA) of the lower leg in a 3-month-old male infant, making it the youngest case in the literature. OFDLA is typically regarded as a benign lesion; however, due to its convertibility into classical adamantinoma, it is recommended to evaluate it as a pre-malignant lesion. After OFDLA diagnosis with biopsy, our case underwent surgical resection and reconstruction with a large allograft. Patient experienced good outcomes and did not experience any local relapse in the 3-year follow-up...
2015: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/25432796/role-of-apparent-diffusion-coefficients-with-diffusion-weighted-magnetic-resonance-imaging-in-differentiating-between-benign-and-malignant-bone-tumors
#11
COMPARATIVE STUDY
Tingting Wang, Xiangru Wu, Yanfen Cui, Caiting Chu, Gang Ren, Wenhua Li
BACKGROUND: Benign and malignant bone tumors can present similar imaging features. This study aims to evaluate the significance of apparent diffusion coefficients (ADC) in differentiating between benign and malignant bone tumors. METHODS: A total of 187 patients with 198 bone masses underwent diffusion-weighted (DW) magnetic resonance (MR) imaging. The ADC values in the solid components of the bone masses were assessed. Statistical differences between the mean ADC values in the different tumor types were determined by Student's t-test...
2014: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/24998665/-delayed-lower-extremity-deep-venous-thrombosis-after-operation-for-osteofibrous-dysplasia-of-the-left-femur-report-of-one-case
#12
Kai Huang, Wei-xing Xu, Chun Zhang
Lower extremity deep venous thrombosis (LDVT) is one of the most common complications in orthopedic surgery, and it often occurs in the first 24 h after operation. We report a case of delayed LDVT, which occurred on d 16 after operation for osteofibrous dysplasia on the left femur. Upon the diagnosis confirmed, thrombolysis and anticoagulation therapy was conducted. The symptoms disappeared 3 weeks later and lower limb vascular ultrasound examination showed no remnant thrombosis.
May 2014: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/24680184/proliferative-reparative-and-reactive-benign-bone-lesions-that-may-be-confused-diagnostically-with-true-osseous-neoplasms
#13
REVIEW
Mark R Wick, Michael B McDermott, Paul E Swanson
Diagnostic problems attending intraosseous and parosteal pseudoneoplastic lesions can be radiographic, or histological, or both. Proliferations in this category may contain cellular fibro-osseous or chondro-osseous tissues that are difficult to separate microscopically from those seen in various true neoplasms of the bones. This review considers the clinicopathologic features of fibrous dysplasia, benign fibro-osseous lesions of the jawbones, osteofibrous dysplasia, metaphyseal fibrous defect, giant-cell reparative granuloma, "brown tumor" of hyperparathyroidism, synovial chondrometaplasia, aneurysmal bone cyst, tumefactive chronic osteomyelitis, proliferative Paget disease, and polyvinylpyrrolidone storage disease of bone...
January 2014: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/24525511/activating-gnas-mutations-in-parosteal-osteosarcoma
#14
Jodi M Carter, Carrie Y Inwards, Long Jin, Barbara Evers, Doris E Wenger, Andre M Oliveira, Karen J Fritchie
Parosteal osteosarcoma is a surface-based osteosarcoma that often exhibits deceptively bland cytologic features, hindering diagnosis in small biopsies or when correlative radiologic imaging is not readily available. A number of benign and malignant fibro-osseous lesions, including fibrous dysplasia (FD) and low-grade central osteosarcoma, fall within the morphologic differential diagnosis of parosteal osteosarcoma. Somatic mutations in GNAS, encoding the α-subunit of the heterotrimeric G protein complex (Gsα), occur in FD and McCune-Albright syndrome but have not been reported in parosteal osteosarcoma...
March 2014: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/24497800/mr-findings-of-the-osteofibrous-dysplasia
#15
Joon-Yong Jung, Won-Hee Jee, Sung Hwan Hong, Heung Sik Kang, Hye Won Chung, Kyung-Nam Ryu, Jee-Young Kim, Soo-A Im, Jeong-Mi Park, Mi-Sook Sung, Yeon-Soo Lee, Suk-Joo Hong, Chan-Kwon Jung, Yang-Guk Chung
OBJECTIVE: The aim of this study was to describe MR findings of osteofibrous dysplasia. MATERIALS AND METHODS: MR images of 24 pathologically proven osteofibrous dysplasia cases were retrospectively analyzed for a signal intensity of the lesion, presence of intralesional fat signal, internal hypointense band, multilocular appearance, cortical expansion, intramedullary extension, cystic area, cortical breakage and extraosseous extension, abnormal signal from the adjacent bone marrow and soft tissue and patterns of contrast enhancement...
January 2014: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/24199850/imaging-in-osteofibrous-dysplasia-osteofibrous-dysplasia-like-adamantinoma-and-classic-adamantinoma
#16
REVIEW
S Bethapudi, D A Ritchie, E Macduff, J Straiton
Fibro-osseous lesions of the bone are well-recognized primary bone tumours. However, given the degree of overlap of imaging findings and variation in management of various sub-types, it is a widely accepted practice to perform a biopsy to obtain histopathological confirmation of the diagnosis. The following is a summary of the epidemiology, clinicopathological features, and review of the imaging features of fibro-osseous lesions, including osteofibrous dysplasia, osteofibrous dysplasia-like adamantinoma, adamantinoma, and lesions that closely mimic them...
February 2014: Clinical Radiology
https://www.readbyqxmd.com/read/23774157/congenital-osteofibrous-dysplasia-campanacci-spontaneous-postbioptic-regression
#17
Björn Jobke, Klaus Bohndorf, Volker Vieth, Mathias Werner
Osteofibrous dysplasia Campanacci is a rare benign bone tumor most frequently observed in young childhood. The exclusive localization in the tibia is very characteristic. The incidence of congenital primary bone tumors is an absolute rarity. We report a case of a newborn with a histologically proven osteofibrous dysplasia Campanacci at the tibia presenting a regular radiographic follow-up. After a small open biopsy and spontaneous minor fracture, the lesion rapidly remodeled within 1½ months and almost completely regressed with restutio ad integrum...
April 2014: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/23559304/dentine-matrix-protein-1-dmp-1-is-a-marker-of-bone-forming-tumours
#18
T G Kashima, A Dongre, U Oppermann, N A Athanasou
Dentin matrix protein 1 (DMP-1) is highly expressed by osteocytes and is a non-collagenous matrix protein found in dentin and bone. In this study, we determined the expression of DMP-1 in mature and immature human bone and examined whether DMP-1 is useful in distinguishing osteoid/bone-forming tumours from other primary and secondary bone tumours. DMP-1 expression was immunohistochemically determined in paraffin sections of a wide range of benign and malignant primary bone tumours and tumour-like lesions (n = 353)...
May 2013: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/23451484/-a-case-of-fibrous-dysplasia-of-temporal-bone
#19
Hongbing Liu, Lixiang Li, Yuehui Liu
Osteofibrous dysplasia is a kind of innocent bone tumor derived from fibrous tissue. Its pathogens has not been identified, it rarely affects the temporal bone, its clinical manifestations mainly is hearing loss. Imageological examination, for example, CT and MRI, is valuable for the diagnosis of this disease,the histopathological evidence is absolutely necessary to make definite diagnosis. Surgery is an effective method to treat the fibrous dysplasia of temporal bone.
December 2012: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/23370769/diagnostic-value-of-investigating-gnas-mutations-in-fibro-osseous-lesions-a-retrospective-study-of-91-cases-of-fibrous-dysplasia-and-40-other-fibro-osseous-lesions
#20
Flore Tabareau-Delalande, Christine Collin, Anne Gomez-Brouchet, Anne-Valérie Decouvelaere, Corinne Bouvier, Frédérique Larousserie, Béatrice Marie, Christophe Delfour, Sébastien Aubert, Philippe Rosset, Anne de Muret, Jean-Christophe Pagès, Gonzague de Pinieux
GNAS (guanine nucleotide-binding protein/α-subunit) mutations that induce the activation of G-protein α-subunit participate in the pathogenesis of fibrous dysplasia. The aim of this study was to evaluate the sensitivity and specificity of GNAS mutations in fibrous dysplasia and other fibro-osseous lesions, to assess the value of investigating this mutation in the diagnosis of fibro-osseous lesions. We studied 91 cases of fibrous dysplasia. The quality and/or quantity of genomic DNA were suitable for molecular analysis for 51 cases of fibrous dysplasia...
July 2013: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
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