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Back ache

Rajnish Kumar, Bengt Långström, Taher Darreh-Shori
Recent reports have brought back the acetylcholine synthesizing enzyme, choline acetyltransferase in the mainstream research in dementia and the cholinergic anti-inflammatory pathway. Here we report, a specific strategy for the design of novel ChAT ligands based on molecular docking, Hologram Quantitative Structure Activity Relationship (HQSAR) and lead optimization. Molecular docking was performed on a series of ChAT inhibitors to decipher the molecular fingerprint of their interaction with the active site of ChAT...
2016: Scientific Reports
Preeti Parashar, Asir John Samuel, Arpna Bansal, Vencita Priyanka Aranka
Yakson is a Korean therapeutic touch given to neonates and infants by caressing their abdomen with one hand while the other hand is placed on the back of the neonate\infant either to relieve their pain or to calm them down. It was traditionally used by Koreans by caressing the aching body part of their children with a belief that it would relieve their pain. In spite of clinical evidence of its usefulness, there is limited literature available on Yakson touch. A systematic narrative review (SNR) was undertaken on studies that were carried out on the effectiveness of Yakson touch on infants and neonates...
June 2016: Indian Journal of Critical Care Medicine
G Sudhir, Kalra K L, Shankar Acharya, Rupinder Chahal
Sacral insufficiency fractures (SIFs) are a common cause of back pain in the elderly. SIFs mimic the symptoms of lumbar spine pathology and so are commonly missed or underdiagnosed. Here we present four cases of missed SIFs that were subsequently identified and treated. One patient was treated as mechanical lower back ache, another patient underwent root block and two patients underwent surgery for lumbar canal stenosis. None experienced relief of their symptoms after these procedures. Retrospective analysis of X-ray and magnetic resonance imaging data revealed SIFs that were confirmed by computed tomography scans...
June 2016: Asian Spine Journal
Sanjay Kumar, Vinay Tomar, Sher S Yadav, Hema Udawat, Shivam Priyadarshi, Nachiket Vyas, Neeraj Agarwal
Primary squamous cell carcinoma (SCC) of renal pelvis is a rare neoplasm. A 75-year old male presented with history of chronic dull aching pain in left flank region for last 10-years with history of left pyelolithotomy about 30-years back. After proper workup, large calculus with heterogeneous density mass detected in nonfunctioning left kidney. After radical nephrectomy, histopathological examination revealed squamous cell carcinoma of renal pelvis. SCC should be suspected in a patient with long history of renal calculous and associated mass in non functioning kidney...
September 2016: Urology Case Reports
Liangchao Sun, Yali Qi, Xindong Sun, Jinming Yu, Xue Meng
Orbital metastasis as the initial presentation of lung adenocarcinoma is very rare, and so the lack of knowledge about this phenomenon can easily result in misdiagnosis, either as a orbital primary tumor or benign lesion. Here, we report a rare case in which the orbital symptom appeared first without any pulmonary manifestations. Our patient developed decreasing vision in his right eye over a 3-month duration. He then presented with proptosis and multiple aches from head to back. After systemic evaluation, our patient was diagnosed with Stage IV non-small-cell lung cancer and was managed with palliative chemoradiotherapy...
2016: OncoTargets and Therapy
Don Gilden, Maria A Nagel
PURPOSE OF REVIEW: Giant cell arteritis (GCA) is a severe form of vasculitis in the elderly. The recent discovery of varicella zoster virus (VZV) in the temporal arteries and adjacent skeletal muscle of patients with GCA, and the rationale and strategy for antiviral and corticosteroid treatment for GCA are reviewed. RECENT FINDINGS: The clinical features of GCA include excruciating headache/head pain, often with scalp tenderness, a nodular temporal arteries and decreased temporal artery pulsations...
July 2016: Current Opinion in Rheumatology
Neha Tambekar, Shaila Sabnis, Apoorva Phadke, Nilima Bedekar
Low back ache (LBA) is a common musculoskeletal disorder sometimes associated with a positive limited Straight leg raise (SLR) test. Mulligan's bent leg raise (BLR) and Butler's neural tissue mobilization (NTM) are commonly used techniques for the treatment of low back ache where SLR is limited. The aim of this study was to evaluate the effect of both the techniques on pain and limited SLR in patients with LBA. Thirty one patients with LBA with radiculopathy were randomly allocated into 2 groups; BLR [n = 16] NTM [n = 15]...
April 2016: Journal of Bodywork and Movement Therapies
Santosh Tummidi, Manoj Kumar Patro, Atanu Kumar Bal, Anita Choudhury
BACKGROUND: Filariasis is a common cause of morbidity in certain parts of India, especially in the Coastal Districts. Repeated episodes of fever with chills and rigor, lymphadenopathy are the initial manifestations which gradually progress to elephantiasis. Wuchereria bancrofti is the most common parasite causing lymphatic filariasis in India. Detecting microfilaria in peripheral blood with or without Diethylcarbamazine citrate provocation is the common diagnostic modality in suspected cases...
2016: BMC Research Notes
Yufeng Luo, Rong Ou, Yun Ling, Tiehe Qin
OBJECTIVE: To investigate the value of high flow nasal cannula (HFNC) in treating a patient with Middle East respiratory syndrome (MERS). METHODS: The effect of HFNC applied in the first imported MERS patient with complication of acute respiratory distress syndrome (ARDS) to China was observed. The patient was admitted to Department of Critical Care Medicine of Huizhou Municipal Central Hospital on May 28th, 2015, and the changes in various clinical parameters and their significance were analyzed...
October 2015: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Aishwarya Vedagiri, Sumathi Thangarajan
Alzheimer's disease (AD) is the most prevalent form of dementia. Amyloid-β25-35 (Aβ25-35), a well-established neurotoxicant, is reported to be involved in the etiology of AD. Chrysin (CN) with its wide range of biological activities in terms of reversing the neuronal damage once induced is limited due to its compromised bioavailability. Solid lipid nanoparticles (SLNs) on the other hand due to its improved protein stability, avoids proteolytic degradation, as well as sustained release of the incorporated molecules could be widely applied as a drug delivery vehicle...
August 2016: Neuropeptides
Romi Singh Nongmaithem, Minggam Pertin, Chongreilen Chiru, Yengkhom Jotin
AIM: To study the bone mineral density (BMD) profile in post-menopausal women and to examine the role of various socio-demographic, clinical, laboratory and radiological factors in predicting fracture risk in these patients. METHODS: This cross-sectional study recruited consenting postmenopausal women presenting with some form of pain complaints, such as joint pain, body ache, low back pain and so on. A structured questionnaire was used to collect socio-demographic details...
March 4, 2016: International Journal of Rheumatic Diseases
Sherene E Sharath, Panos Kougias, George Pisimisis, Neal R Barshes
OBJECTIVE: To understand the relationship between self-perceived severity of intermittent claudication and various associated nonclinical factors, we examined how correlates in domains of physical activity (ie, clinical, psychological, behavioral, social, and environmental factors) relate to exertional limb symptoms. METHODS: A survey was administered to individuals with intermittent claudication during their initial outpatient assessment. The subjects' self-reported exertional limb symptom severity and classic-versus-atypical claudication classification was based on the Walking Impairment Questionnaire (WIQ) and San Diego Claudication Questionnaire (SDCQ), respectively...
May 2016: Journal of Vascular Surgery
Thiruvaipati Pn Hariprasad, Nadikere J Shetty
BACKGROUND: Anopheles stephensi is an important urban malaria vector in the Indian subcontinent. Extensive application of insecticides evokes microevolution, which results in resistance that can be traced back to their genotypes. In this study, resistant and susceptible strains of An. stephensi for alphamethrin were selected by selective inbreeding for 27 and ten generations respectively. The biochemical basis of resistance in all the life stages was investigated. Quantitative assays were performed for proteins (total and soluble), esterases (α, β and acetylcholine) and phosphatases (acid and alkaline) by spectrophotometry, and qualitative assays for the enzymes by native polyacrylamide gel electrophoresis...
September 2016: Pest Management Science
Yun Ling, Rong Qu, Yufeng Luo
OBJECTIVE: To report the treatment of the first imported Middle East respiratory syndrome ( MERS ) in China, and to investigate the clinical features and treatment of the patient. METHODS: On May 28th, 2015, the first patient of imported MERS to China was admitted to Department of Critical Care Medicine of Huizhou Municipal Central Hospital. The clinical features and treatments of this patient were analyzed. RESULTS: (1) A 43 years old male of South Korean nationality was admitted with the complaint of back ache for 7 days and fever 2 days with the following characteristics: back ache 7 days ago, without fever or cough or expectoration...
August 2015: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Anish Ashok Gupta, Shubhangi Ashok Mhaske, Malik Ajaz Ahmad, Monal B Yuwanati, Shweta Prabhu, Nilesh Pardhe
BACKGROUND: Prolonged use of conventional microscope develops musculo-skeletal injuries like chronic pain syndrome, including shoulder, neck, back aches & fatigue. Since the problems go unnoticed, the injuries can lead to some serious permanent damages. This further leads to a compromise in the health and welfare of the person and the institute. Hence, an understanding about the ergonomics is the need of the hour in this postmodern era. Inspite of few studies and surveys about ergonomics, there is still a steep rise in the musculoskeletal disorders...
May 2015: Journal of Clinical and Diagnostic Research: JCDR
Ravi Kumar T V, Raghavendra Rao, Daksh Gadi, Amit Grover
Posterior apophyseal ring fracture is a rare condition typically seen in adolescent age group because the ring apophysis and the adjacent vertebral body does not fuse completely and may separate at the cephalad or caudal edge. It usually simulates disc herniation in adolescents and children but disc lesion is very commonly associated with PRAF. The condition although is rare but a high index of suspicion should be there during evaluation of any adolescent patient with low back ache as it is often missed on conventional radiography...
May 2015: Journal of Clinical and Diagnostic Research: JCDR
Geeta Shroff, J K Barthakur
BACKGROUND: Human embryonic stem cells (hESCs) are pluripotent cells that have the potential to self-renew and differentiate into all types of human cells. PURPOSE: The present study was aimed at establishing the safety of hESC therapy in patients with terminal/incurable conditions. METHODS: This was a single cohort study conducted at Nutech Mediworld, New Delhi. The patients suffering from various degenerative diseases were included in the study from year 2002 to 2004...
July 2015: Annals of Neurosciences
Constantine Farmakidis, Seniha Inan, Mark Milstein, Steven Herskovitz
While moderate and severe back or extremity pain is frequent in Guillain-Barré syndrome (GBS), headache appears to be uncommon. Most of the reports of headache in GBS place it in the context of the posterior reversible encephalopathy syndrome (PRES) which is increasingly recognized as a likely dysautonomia-related GBS complication. There are also a few reports of headache in the setting of increased CSF pressure and papilledema and in association with the Miller Fisher GBS variant. In comparison, back and extremity pain is highly prevalent...
August 2015: Current Pain and Headache Reports
Bożena Mroczek, Joanna Banaś, Małgorzata Machowska-Szewczyk, Donata Kurpas
OBJECTIVES: Health-related quality of life (HRQoL) can serve as a multidimensional means of evaluating the relationship between the presence of wind turbines in residential areas and their consequence for health. The purpose of this study was to determine whether a relationship exists between the presence of wind farms at different stages of development and the HRQoL of people living in their vicinity in Poland. METHOD: The instruments employed in this study were the SF-36v2, a questionnaire measuring self-reported health problems, and a sociodemographic questionnaire...
June 2015: International Journal of Environmental Research and Public Health
Sitanshu Sekhar Kar, L Subitha, S Kalaiselvi, R Archana
BACKGROUND: The workplace is increasingly being used as a setting for health promotion and preventive health activities; not only to prevent occupational injury, but to assess and improve people's overall health. OBJECTIVE: This study aims at developing and implementing a healthy workplace model in a software industry of Puducherry. METHODS: Operations research was carried out in a purposively selected industry in Puducherry. The study was planned in four phases-baseline assessment and risk profiling, intervention, final evaluation and dissemination of results...
January 2015: Indian Journal of Occupational and Environmental Medicine
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