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https://www.readbyqxmd.com/read/29780233/spinal-meningeal-melanocytoma-in-a-5-year-old-child-a-case-report-and-review-of-literature
#1
Ahmed M Salah El-Din, Hashem M Aboul-Ela, Mohamed F Alsawy, Ahmed Koheil, Ahmed H Ashry
Background: Meningeal melanocytoma is considered a rare lesion arising from leptomeningeal melanocytes. Nearly two thirds of meningeal melanocytomas were reported in the intracranial compartment and the remaining one third in the spine. Spinal melanocytomas can be extradural or intradural, with extradural variant being more common, and the majority of cases have been single reports. Methods: A 5-year-old male presented with a 4-month history of non-radiating low back pain persistent at rest, with otherwise non-remarkable medical history...
2018: Egypt J Neurol Psychiatr Neurosurg
https://www.readbyqxmd.com/read/29747078/mechanisms-of-acetylcholinesterase-protection-against-sarin-and-soman-by-adenosine-a-1-receptor-agonist-n-6-cyclopentyladenosine
#2
Ariana Beste, DeCarlos E Taylor, Tsung-Ming Shih, Thaddeus P Thomas
Organophosphorus nerve agents (NAs) irreversibly inhibit acetylcholinesterase (AChE), the enzyme responsible for breaking down the neurotransmitter acetylcholine (ACh). The over accumulation of ACh after NA exposure leads to cholinergic toxicity, seizure, and death. Current medical countermeasures effectively mitigate peripheral symptoms, however; the brain is often unprotected. Alternative acute treatment with the adenosine A1 receptor agonist N6 -cyclopentyladensosine (CPA) has previously been demonstrated to prevent AChE inhibition as well as to suppress neuronal activity...
May 7, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29703017/osteochondroma-of-ventral-scapula-associated-with-chest-pain-due-to-rib-cage-compression-a-case-report
#3
Dong-Il Chun, Jae-Ho Cho, In Ho Choi, Young Yi, Jun Yong Kim, Jae Heon Kim, Sung Hun Won
RATIONALE: The scapula is relatively rare site for osteochondroma. Scapula osteochondroma is usually asymptomatic, however it may present with features such as pseudowinging, snapping scapula, bursa formation, chronic pain, and cosmetic deformities. To our best knowledge, this is the first report in the English literature about osteochondroma of ventral scapula associated with chest pain due to rib cage compression. PATIENT CONCERNS: A 14-year-old boy was transferred to the orthopedic clinic from thoracic surgery department with a complaint of intermittent, dull, and diffuse aching pain around left chest wall and back from the past 2 months...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29669593/association-between-general-joint-hypermobility-and-knee-hip-and-lumbar-spine-osteoarthritis-by-race-a-cross-sectional-study
#4
Portia P E Flowers, Rebecca J Cleveland, Todd A Schwartz, Amanda E Nelson, Virginia B Kraus, Howard J Hillstrom, Adam P Goode, Marian T Hannan, Jordan B Renner, Joanne M Jordan, Yvonne M Golightly
BACKGROUND: Osteoarthritis (OA) prevalence differs by race. General joint hypermobility (GJH) may be associated with OA, but differences by race are not known. This community-based study examined the frequency of GJH and its relationship with knee, hip, and lumbar spine OA by race (African American vs. Caucasian). METHODS: Data were from the Johnston County OA project, collected 2003-2010. GJH was defined as Beighton score ≥4. OA symptoms were defined as the presence of pain, aching, or stiffness on most days separately at the knee, hip, and lower back...
April 18, 2018: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29656511/neuropathic-pain-a-patient-centred-approach-to-measuring-outcomes
#5
Steve Hwang, Floortje van Nooten, Ted Wells, Aisling Ryan, Bruce Crawford, Christopher Evans, Marci English
BACKGROUND: Neuropathic pain (NP) is a complex, chronic pain state initiated by a primary lesion or dysfunction of the nervous system and presents as a variety of symptoms across multiple disease states. OBJECTIVE: To develop a patient-centred conceptual model of symptoms and impacts in subjects with diabetic peripheral neuropathy (DPN) or post-herpetic neuralgia (PHN) that can inform the measurement strategy in clinical trials. METHOD: Thirty subjects with DPN or PHN participated in in-person interviews which were performed until saturation was achieved...
April 15, 2018: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29643678/metabolic-bone-superscan-in-carcinoma-breast-with-occult-graves-disease-looking-beyond-skeletal-metastases
#6
Ashwin Singh Parihar, Ashwani Sood, Tinu Thadiyananickal Lukose, Rajeev Kumar Seam, Bhagwant Rai Mittal
Extrathyroidal manifestations of autoimmune thyroid disorders include thyroid-associated ophthalmopathy, thyroid dermopathy, and thyroid acropachy. Thyroid acropachy is an extreme manifestation of autoimmune thyroid disorder characterized by clubbing and swelling of fingers and toes, with or without periosteal reaction of the distal bones. We present a 50-year-old woman, posttreatment for carcinoma breast (6 years back) and referred for bone scan for generalized body ache. Bone scan findings resulting in detailed clinical evaluation prompted toward the suspicion of a thyroidal disease with ultimate diagnosis of Graves' disease...
April 2018: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29545868/diagnosis-and-management-of-spinal-tuberculosis-combined-with-brucellosis-a-case-report-and-literature-review
#7
Dexin Zou, Junlin Zhou, Xiaobing Jiang
Tuberculosis combined with brucellosis is a very rare condition. Overlapping clinical presentation and laboratory parameters of tuberculosis and brucellosis may lead to misdiagnosis or delayed diagnosis of the condition. The current study presents the case of a 45-year-old male with symptoms of lower back pain, non-tender swelling in the right flank, intermittent hyperpyrexia, sweating, body aches and numbness and weakness of right lower limb. A lumbar computed tomograph (CT) scan and magnetic resonance imaging indicated vertebral destruction and the formation of sequestra and thecal sac compression...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29432327/mixed-methods-development-of-a-new-patient-reported-outcome-instrument-for-chronic-low-back-pain-part-1-the-patient-assessment-for-low-back-pain-symptoms-pal-s
#8
Mona L Martin, Steven I Blum, Hiltrud Liedgens, Donald M Bushnell, Kelly P McCarrier, Noël V Hatley, Abhilasha Ramasamy, Rainer Freynhagen, Mark Wallace, Charles Argoff, Mariёlle Eerdekens, Maurits Kok, Donald L Patrick
We describe the mixed-methods (qualitative and quantitative) development and preliminary validation of the Patient Assessment for Low Back Pain-Symptoms (PAL-S), a patient-reported outcome measure for use in chronic low back pain (cLBP) clinical trials. Qualitative methods (concept elicitation and cognitive interviews) were used to identify and refine symptom concepts and quantitative methods (classical test theory and Rasch measurement theory) were used to evaluate item- and scale-level performance of the measure using an iterative approach...
February 7, 2018: Pain
https://www.readbyqxmd.com/read/29367870/epstein-barr-virus-related-cutaneous-necrotizing-vasculitis-in-a-girl-heterozygous-for-factor-v-leiden
#9
Cristina Guerriero, Gaia Moretta, Giulia Bersani, Piero Valentini, Antonio Gatto, Donato Rigante
Background: Necrotizing vasculitides are basically characterized by vessel wall neutrophil infiltration and necrosis and they can occur as a primary process or secondary to an underlying disease. Although Henoch-Schönlein purpura (HSp) is the more frequent primary vasculitis in childhood, sometimes it has to be distinguished from other secondary vasculitides induced by infections, drugs, vaccines, or immune-mediated disorders. Main observations: We report a case of a 14-year-old girl with cutaneous necrotizing vasculitis, appearing in the course of acute Epstein-Barr virus infection...
December 1, 2017: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/29283444/vasodilator-dysfunction-and-oligodendrocyte-dysmaturation-in-aging-white-matter
#10
Zsolt Bagi, Dieter D Brandner, Phuong Le, David W McNeal, Xi Gong, Huijuan Dou, David J Fulton, Allison Beller, Thuan Ngyuen, Eric B Larson, Thomas J Montine, C Dirk Keene, Stephen A Back
OBJECTIVE: Microvascular brain injury (mVBI) is a common pathological correlate of vascular contributions to cognitive impairment and dementia (VCID) that leads to white matter (WM) injury (WMI). VCID appears to arise from chronic recurrent white matter ischemia that triggers oxidative stress and an increase in total oligodendrocyte lineage cells. We hypothesized that mVBI involves vasodilator dysfunction of white matter penetrating arterioles and aberrant oligodendrocyte progenitor cell (OPC) responses to WMI...
January 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29142359/non-hodgkin-s-lymphoma-with-pelvic-skeletal-muscle-involvement-presenting-as-low-back-ache-an-uncommon-presentation-of-a-rather-common-malignancy
#11
Arun Ravi John, G P S Gahlot, Braj Kishore Singh, Anurag Jain, Abhishek Mahato, M J Jacob
Lymphoma with skeletal muscle involvement is a rare clinical presentation. They may occur as primary skeletal muscle lymphoma, contiguous spread from bones or by metastatic spread. We present a rare case of non-Hodgkin's lymphoma with pelvic skeletal muscle involvement presenting as low back ache. Lymphoma as the first differential diagnosis in this case was clinched after an18 F-fluorodeoxyglucose positron emission tomography (FDG-PET) and confirmed as diffuse large B-cell lymphoma on histopathology. We seek to present an uncommon manifestation of lymphoma and highlight the role of18 F-FDG PET CT in the diagnosis, staging, and management of lymphoma...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29136790/paper-based-amperometric-sensor-for-determination-of-acetylcholinesterase-using-screen-printed-graphene-electrode
#12
Yosita Panraksa, Weena Siangproh, Thitikan Khampieng, Orawon Chailapakul, Amara Apilux
A simple paper-based sensor with electrochemical detection was first developed for rapid, selective, and sensitive determination of acetylcholinesterase (AChE). The screen-printed graphene electrode was used as working electrode providing sensitivity for the sensor. The amperometric detection of AChE is based on the determination of thiocholine (TCh) produced from hydrolysis of acetylthiocholine chloride (ATCh) by AChE. To detect TCh, the ATCh immobilized sheet was stacked onto the detection sheet using double adhesive tape, then samples of AChE were dropped on the back side of an ATCh immobilized sheet with only 1min of incubation time...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/28919625/van-wyk-and-grumbach-syndrome-an-unusual-presentation-of-hypothyroism
#13
P K Chanda, M Kamrul-Hasan, M Abu-Bakar, M Rahman, M A Kader, M A Hossain, N I Siddiqui
An 18 years-old-girl presented one and half years back with the complaints of short stature, retarded growth, and menorrhagia with sudden severe lower abdominal pain; was diagnosed as bilateral ovarian cysts and underwent bilateral ovarian cystectomy. Later on she was incidentally diagnosed as a case of hypothyroidism when she had been experiencing slowly enlarging left lower abdominal mass with dull ache for the 5 month and then was transferred to the department of Endocrinology for further evaluation. Detailed work up revealed her short stature with obesity, delayed bone age and other features of hypothyroidism which was confirmed by thyroid function testing...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28910309/pattern-and-severity-of-multimorbidity-among-patients-attending-primary-care-settings-in-odisha-india
#14
RANDOMIZED CONTROLLED TRIAL
Sanghamitra Pati, Subhashisa Swain, Job Metsemakers, J André Knottnerus, Marjan van den Akker
Multimorbidity is increasingly the primary concern of healthcare systems globally with substantial implications for patient outcomes and resource cost. A critical knowledge gap exists as to the magnitude of multimorbidity in primary care practice in low and middle income countries with available information limited to prevalence. In India, primary care forms the bulk of the health care delivery being provided through both public (community health center) and private general practice setting. We undertook a study to identify multimorbidity patterns and relate these patterns to severity among primary care attendees in Odisha state of India...
2017: PloS One
https://www.readbyqxmd.com/read/28899700/the-agony-of-it-all-musculoskeletal-discomfort-in-the-reading-room
#15
Rebecca L Seidel, Elizabeth A Krupinski
PURPOSE: The purpose of this study was to determine the extent and severity of musculoskeletal discomfort in radiologists using a standardized tool, the Cornell Musculoskeletal Discomfort Questionnaire (CMDQ). In addition, we evaluated the influence of demographic factors on the frequency of symptoms, degree of discomfort, interference of symptoms with ability to work, and overall pain. METHODS: The CMDQ was distributed via an anonymous link to all radiology trainees and faculty at our institution...
December 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28845945/-laparoscopic-antevasal-uretero-ureteral-anastomosis-for-treating-retrocaval-ureter
#16
B K Komyakov, B G Guliev, Sh N Idrisov, R G Shibliev
The article presents a case of laparoscopic antevasal correction of the retrocaval ureter in a 16 year old patient, who was admitted to the hospital with complaints of aching pain in the right lower back. His history was noteworthy of early age onset of intermittent fever accompanied by abdominal and lumbar pain. Blood count and urinalysis were within normal limits, and he was treated symptomatically. However, no renal ultrasound scan was done. Intravenous urography and MSCT showed a retrocaval ureter. The diagnosis was confirmed by retrograde ureteropyelography...
July 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28841665/prevalence-and-pattern-of-co-morbidity-among-type2-diabetics-attending-urban-primary-healthcare-centers-at-bhubaneswar-india
#17
Sandipana Pati, F G Schellevis
OBJECTIVE: India has the second largest diabetic population in the world. The chronic nature of the disease and high prevalence of co-existing chronic medical conditions or "co morbidities" makes diabetes management complex for the patient and for health care providers. Hence a strong need was felt to explore the problem of co morbidity among diabetics and its dimensions in primary health care practices. METHOD: This cross sectional survey was carried out on 912 type 2 diabetes patients attending different urban primary health care facilities at Bhubaneswar...
2017: PloS One
https://www.readbyqxmd.com/read/28769073/compensatory-vasodilator-mechanisms-in-the-ophthalmic-artery-of-endothelial-nitric-oxide-synthase-gene-knockout-mice
#18
Caroline Manicam, Natalja Ginter, Huige Li, Ning Xia, Evgeny Goloborodko, Jenia Kouchek Zadeh, Aytan Musayeva, Norbert Pfeiffer, Adrian Gericke
Nitric oxide (NO) generated by endothelial nitric oxide synthase (eNOS) plays an important role in the maintenance of ocular vascular homeostasis. Therefore, perturbations in vascular NO synthesis have been implicated in the pathogenesis of several ocular diseases. We recently reported that eNOS contributes significantly to vasodilation of the mouse ophthalmic artery. Interestingly, dilatory responses were also retained in eNOS gene-deficient mice (eNOS-/-), indicating inherent endothelial adaptive mechanism(s) that act as back-up systems in chronic absence of eNOS to preserve vasorelaxation...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723110/portable-sensor-for-the-detection-of-choline-and-its-derivatives-based-on-silica-isoporous-membrane-and-gellified-nanointerfaces
#19
Lisiqi Xie, Xiao Huang, Bin Su
A portable amperometric ion sensor was fabricated by integrating silica isoporous membrane (SIM) and organogel composed of polyvinyl chloride and 1,2-dichloroethane (PVC-DCE) on a 3D-printed polymer chip. The detection of ionic species in aqueous samples could be accomplished by adding a microliter of sample droplet to the sensor and by identifying the ion-transfer potential and current magnitude at the water/organogel interface array templated by SIM. Thanks to the ultrasmall channel size (2-3 nm in diameter), high channel density (4 × 10(8) μm(-2)), and ultrathin thickness (80 nm) of SIM, the ensemble of nanoscopic water/organogel (nano-W/Gel) interface array behaved like a microinterface with two back-to-back hemispherical mass diffusion zones...
June 23, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28672421/-acute-coronary-syndrome-what-should-the-general-practitioner-do
#20
REVIEW
Stefan Stadler, Dierk Endemann, Lars S Maier
Acute myocardial infarction is the second most common cause of mortality in Germany after chronic ischemic cardiac disease. It is essential to think of acute coronary syndrome also in patients who do not present with typical signs (pressure, tightness, pain, or a squeezing or aching sensation in the chest or arms that may spread to the neck, jaw or back) in the general practitioner's practice. Vital signs (blood pressure, heart rate and oxygen saturation) must be measured; an ECG should be recorded and analyzed within ten minutes of first medical contact...
July 2017: Deutsche Medizinische Wochenschrift
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