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S100B, IL-6

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https://www.readbyqxmd.com/read/27468243/early-detection-of-neonatal-group-b-streptococcus-sepsis-and-the-possible-diagnostic-utility-of-il-6-il-8-and-cd11b-in-a-human-umbilical-cord-blood-in-vitro-model
#1
Britt Nakstad, Tonje Sonerud, Anne Lee Solevåg
BACKGROUND: Group B streptococcus (GBS) infection remains a major cause of neonatal morbidity and mortality, and GBS III is the predominant strain in early-onset GBS neonatal sepsis. To avoid both over- and undertreatment of infants with nonspecific signs of infection, early diagnostic tools are warranted. The aim of this study was to identify biomarkers with high sensitivity and specificity in an early stage of GBS infection. A secondary aim was to assess the utility of a human umbilical cord blood (HUCB) model system of early-onset neonatal sepsis...
2016: Infection and Drug Resistance
https://www.readbyqxmd.com/read/27416040/molecular-signaling-and-dysfunction-of-the-human-reactive-enteric-glial-cell-phenotype-implications-for-gi-infection-ibd-poi-neurological-motility-and-gi-disorders
#2
Andromeda Liñán-Rico, Fabio Turco, Fernando Ochoa-Cortes, Alan Harzman, Bradley J Needleman, Razvan Arsenescu, Mahmoud Abdel-Rasoul, Paolo Fadda, Iveta Grants, Emmett Whitaker, Rosario Cuomo, Fievos L Christofi
BACKGROUND: Clinical observations or animal studies implicate enteric glial cells in motility disorders, irritable bowel syndrome, inflammatory bowel disease, gastrointestinal (GI) infections, postoperative ileus, and slow transit constipation. Mechanisms underlying glial responses to inflammation in human GI tract are not understood. Our goal was to identify the "reactive human enteric glial cell (rhEGC) phenotype" induced by inflammation, and probe its functional relevance. METHODS: Human enteric glial cells in culture from 15 GI-surgical specimens were used to study gene expression, Ca, and purinergic signaling by Ca/fluo-4 imaging and mechanosensitivity...
August 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27026184/hippocampal-astrocyte-cultures-from-adult-and-aged-rats-reproduce-changes-in-glial-functionality-observed-in-the-aging-brain
#3
Bruna Bellaver, Débora Guerini Souza, Diogo Onofre Souza, André Quincozes-Santos
Astrocytes are dynamic cells that maintain brain homeostasis, regulate neurotransmitter systems, and process synaptic information, energy metabolism, antioxidant defenses, and inflammatory response. Aging is a biological process that is closely associated with hippocampal astrocyte dysfunction. In this sense, we demonstrated that hippocampal astrocytes from adult and aged Wistar rats reproduce the glial functionality alterations observed in aging by evaluating several senescence, glutamatergic, oxidative and inflammatory parameters commonly associated with the aging process...
March 30, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26915823/effect-of-diesel-exhaust-inhalation-on-blood-markers-of-inflammation-and-neurotoxicity-a-controlled-blinded-crossover-study
#4
Rachel Cliff, Jason Curran, Jeremy A Hirota, Michael Brauer, Howard Feldman, Chris Carlsten
CONTEXT: Epidemiological studies and animal research have suggested that air pollution may negatively impact the central nervous system (CNS). Controlled human exposure studies of the effect of air pollution on the brain have potential to enhance our understanding of this relationship and to inform potential biological mechanisms. OBJECTIVES: Biomarkers of systemic and CNS inflammation may address whether air pollution exposure induces inflammation, with potential for CNS negative effects...
2016: Inhalation Toxicology
https://www.readbyqxmd.com/read/26815566/the-influence-of-bone-cement-implantation-in-primary-hip-arthroplasty-on-s100b-protein-serum-concentration-and-patients-cognitive-functions-as-markers-of-brain-damage
#5
Dariusz Tomaszewski, Zbigniew Rybicki, Marcin Możański
OBJECTIVE: The objective of the study was to evaluate the influence of the bone cement used during primary hip arthroplasty on brain functions assessed at the biochemical and clinical levels. The S100B protein is a biochemical marker of brain damage. Its plasma concentration was compared with the results of neuropsychological tests, conducted during the perioperative period. PATIENTS AND METHODS: Two groups of patients who underwent primary hip arthroplasty were analyzed; group one (n = 30) with the use of bone cement (cemented), group two (n = 30) without (cementless)...
February 2010: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/26713528/-effects-of-ulinastatin-on-cognitive-function-in-patients-with-coronary-artery-bypass-grafting
#6
RANDOMIZED CONTROLLED TRIAL
Ya-li Ge, Hong-wei Shi, Wen-fei Zhu, Zheng-Liang Ma, Hai-yan Wei, Xiao-ping Gu, Hong-guang Bao
OBJECTIVE: To investigate the effects of ulinastatin(UTI) on postoperative cognitive function in patients undergoing coronary artery bypass grafting. METHODS: One hundred and twenty-seven patients undergoing elective coronary artery bypass surgery were randomly divided into three groups:high-dose UTI group(16000 U/kg i.v.), low-dose UTI group(8000 U/kg i.v.) and control group(normal saline). The levels of plasma cortisol were measured before and one day after surgery...
September 2015: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/26705843/principal-components-derived-from-csf-inflammatory-profiles-predict-outcome-in-survivors-after-severe-traumatic-brain-injury
#7
Raj G Kumar, Jonathan E Rubin, Rachel P Berger, Patrick M Kochanek, Amy K Wagner
Studies have characterized absolute levels of multiple inflammatory markers as significant risk factors for poor outcomes after traumatic brain injury (TBI). However, inflammatory marker concentrations are highly inter-related, and production of one may result in the production or regulation of another. Therefore, a more comprehensive characterization of the inflammatory response post-TBI should consider relative levels of markers in the inflammatory pathway. We used principal component analysis (PCA) as a dimension-reduction technique to characterize the sets of markers that contribute independently to variability in cerebrospinal (CSF) inflammatory profiles after TBI...
March 2016: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/26472263/the-effects-of-selective-head-cooling-versus-whole-body-cooling-on-some-neural-and-inflammatory-biomarkers-a-randomized-controlled-pilot-study
#8
RANDOMIZED CONTROLLED TRIAL
Yalçın Çelik, Aytuğ Atıcı, Selvi Gülaşı, Khatuna Makharoblıdze, Gülçin Eskandari, Mehmet Ali Sungur, Serin Akbayır
BACKGROUND: Therapeutic hypothermia (TH) has become standard care in newborns with moderate to severe hypoxic ischemic encephalopathy (HIE), and the 2 most commonly used methods are selective head cooling (SHC) and whole body cooling (WBC). This study aimed to determine if the effects of the 2 methods on some neural and inflammatory biomarkers differ. MATERIALS AND METHODS: This prospective randomized pilot study included newborns delivered after >36 weeks of gestation...
2015: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/26051664/early-dynamics-of-p-selectin-and-interleukin-6-predicts-outcomes-in-ischemic-stroke
#9
Gabriella Pusch, Birgit Debrabant, Tihamer Molnar, Gergely Feher, Viktoria Papp, Miklos Banati, Norbert Kovacs, Laszlo Szapary, Zsolt Illes
BACKGROUND: Thromboinflammatory molecules connect the prothrombotic state, endothelial dysfunction, and systemic/local inflammation in the acute phase of ischemic stroke. METHODS: We prospectively investigated (1) serial changes in the levels of thromboinflammatory biomarkers in 76 patients with acute ischemic stroke (6, 24, and 72 hours after onset); (2) compared with 44 patients with asymptomatic severe (≥70%) carotid stenosis and 66 patients with Parkinson disease; and (3) we applied multiple regression methods, relating biological biomarkers combined with demographic data and comorbidities to poststroke infection, death, and functional outcome, and assessed the ability of the models to predict each outcome...
August 2015: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/25843159/the-biomarkers-of-fetal-growth-in-intrauterine-growth-retardation-and-large-for-gestational-age-cases-from-adipocytokines-to-a-metabolomic-all-in-one-tool
#10
REVIEW
Angelica Dessì, Chiara Pravettoni, Flaminia Cesare Marincola, Andrea Schirru, Vassilios Fanos
Adipose tissue is no longer considered as inert; the literature describes the role it plays in the production of many substances, such as adiponectin, visfatin, ghrelin, S100B, apelin, TNF, IL-6 and leptin. These molecules have specific roles in humans and their potential as biomarkers useful for identifying alterations related to intrauterine growth retardation and large for gestational age neonates is emerging. Infants born in such conditions have undergone metabolic changes, such as fetal hypo- or hyperinsulinemia, which may lead to development of dysmetabolic syndrome and other chronic diseases in adulthood...
June 2015: Expert Review of Proteomics
https://www.readbyqxmd.com/read/25613713/lipopolysaccharide-binding-protein-interleukin-10-interleukin-6-and-c-reactive-protein-blood-levels-in-acute-ischemic-stroke-patients-with-post-stroke-infection
#11
Hans Worthmann, Anita B Tryc, Meike Dirks, Ramona Schuppner, Korbinian Brand, Frank Klawonn, Ralf Lichtinghagen, Karin Weissenborn
BACKGROUND: Ischemic stroke patients are prone to infection by stroke-induced immunodepression. We hypothesized that levels of lipopolysaccharide binding protein (LBP), interleukin-10 (IL-10), IL-6 and C-reactive protein (CRP) are early predictors for the development of stroke-associated infection. METHODS: Fifty-six patients with ischemic stroke (n = 51) and transient ischemic attack (TIA) (n = 5) who presented within 6 hours after symptom onset and who were free of detectable infection on admission were included in the study...
2015: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/25573795/maternal-serum-s100-b-papp-a-and-il-6-levels-in-severe-preeclampsia
#12
Burcu Artunc-Ulkumen, Yesim Guvenc, Asli Goker, Ceyhun Gozukara
AIM: We aimed to investigate the relationship of maternal serum levels of S100-B, PAPP-A and IL-6 with severe preeclampsia. MATERIALS AND METHODS: This prospective case-control study consisted of 27 severe preeclamptic and 36 healthy singleton pregnancies. The groups were matched for parity, maternal age and body mass index. Maternal blood sampling for S100B, PAPP-A and IL-6 was performed at the morning after an overnight fasting. RESULTS: S100-B concentrations were significantly higher in severe preeclampsia group (0...
July 2015: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/25553084/use-of-proteins-as-biomarkers-and-their-role-in-carcinogenesis
#13
REVIEW
Paul Zarogoulidis, Kosmas Tsakiridis, Chrisanthi Karapantzou, Sofia Lampaki, Ioannis Kioumis, Georgia Pitsiou, Antonis Papaiwannou, Wolfgang Hohenforst-Schmidt, Haidong Huang, George Kesisis, Ilias Karapantzos, Serafeim Chlapoutakis, Ippokratis Korantzis, Andreas Mpakas, Vasilis Karavasilis, Ioannis Mpoukovinas, Qiang Li, Konstantinos Zarogoulidis
SUMMARY: Improved diagnostic methods and medical therapies are necessary for early detection and treatment and an improved prognosis. It is thus vital to both examine and evaluate the role of the various existing proteins as biomarkers in carcinogenesis and to assess the contribution of these proteins in anti-cancer activity, for consideration in therapeutic strategies. It is essential to both examine and evaluate the role of the various existing proteins as biomarkers in carcinogenesis and to assess the contribution of these proteins in anti-cancer activity, for consideration in therapeutic strategies...
2015: Journal of Cancer
https://www.readbyqxmd.com/read/25471997/potential-role-of-blood-biomarkers-in-the-management-of-nontraumatic-intracerebral-hemorrhage
#14
REVIEW
Rebecca Senn, Mitchell S V Elkind, Joan Montaner, Mirjam Christ-Crain, Mira Katan
BACKGROUND: Intracerebral hemorrhage (ICH), a subtype of stroke associated with high mortality and disability, accounts for 13% of all strokes. Basic and clinical research has contributed to our understanding of the complex pathophysiology of neuronal injury in ICH. Outcome rates, however, remain stable, and questions regarding acute management of ICH remain unanswered. Newer research is aiming at matching measured levels of serum proteins, enzymes, or cells to different stages of brain damage, suggesting that blood biomarkers may assist in acute diagnosis, therapeutic decisions, and prognostication...
2014: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/25153417/s100b-concentrations-increase-perioperatively-in-jugular-vein-blood-despite-limited-metabolic-and-inflammatory-response-to-clinically-uneventful-carotid-endarterectomy
#15
Berndt Arfvidsson, Torbjörn K Nilsson, Lars Norgren
BACKGROUND: Our aim was to test the hypothesis that metabolic and inflammatory responses of the brain perioperatively during carotid endarterectomy (CEA) might affect blood brain barrier (BBB) integrity. METHODS: Twenty patients with >70% stenosis of internal carotid artery (ICA) were prospectively included. Surgery was performed under general anaesthesia. Blood was sampled from ipsilateral internal jugular vein and radial artery: just before, during, and after ICA clamping S100B protein, glucose, lactate, 20 amino acids, and key cytokines were analysed...
January 2015: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/25120758/s100b-ranks-as-a-new-marker-of-multiple-traumas-in-patients-and-may-accelerate-its-development-by-regulating-endothelial-cell-dysfunction
#16
Xingbo Dang, Laishun Guan, Wei Hu, Gongliang Du, Jun Li
S100 calcium binding protein B (S100B) is recently known as the markers for inflammatory diseases. However, its roles and underlying mechanism on multiple-traumas remain unclearly. In this study, total 123 patients (87 male and 36 female) were enrolled and divided into two group: Injury severity score (ISS) ≥ 16 (n = 69); ISS < 16 (n = 54). ELISA assay confirmed that the circulating S100B levels in multi-trauma were obviously higher than that in healthy volunteers. Additionally, S100B concentrations was associated with injury severity as an obviously higher levels of S100B (2...
2014: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/25064445/serum-biomarkers-to-evaluate-the-integrity-of-the-neurovascular-unit
#17
REVIEW
Imran N Mir, Lina F Chalak
Biomarkers have the potential to enable the clinicians to screen infants for brain injury, monitor progression of disease, identify injured brain regions, assess efficacy of neuroprotective therapies, and offer hope to identify the timing of the injury, thus shedding light on the potential pathophysiology and the most effective therapy. Currently, clinicians do not routinely use biomarkers to care for neonates with Neonatal Encephalopathy (NE) and brain injury due to prenatal hypoxia-asphyxia. This review will cover potential biomarkers of the neurovascular unit in the setting of NE that (i) can help assess the degree or severity of encephalopathy at birth; (ii) can help monitor progression of disease process and efficacy of neuroprotective therapy; (iii) can help assess neurodevelopmental outcome...
October 2014: Early Human Development
https://www.readbyqxmd.com/read/24974887/the-use-of-cytokine-signature-patterns-separating-drug-na%C3%A3-ve-interferon-and-natalizumab-treated-multiple-sclerosis-patients
#18
Kara E O'Connell, Tzehow Mok, Brian Sweeney, Aisling M Ryan, Kumlesh K Dev
Multiple sclerosis (MS) is an inflammatory illness characterized by demyelination and axonal neurodegeneration. Here, we used serum samples from MS patients to demonstrate if "cytokine signature" patterns can separate different patient groups better than using single cytokines. In this case, we used cytokine profiling to demonstrate if "cytokine signature" patterns can separate MS patients treated with interferon or natalizumab from drug naïve patients. Serum levels of eight individual cytokines (TNFα, IFNγ, S100B, IL-1β, IL-6, IL-8, IL-17 and IL-23) in MS patients treated with interferons (n = 11) and natalizumab (n = 14) were measured and, in general, showed reduced levels compared to drug naïve MS patients (n = 12)...
December 2014: Autoimmunity
https://www.readbyqxmd.com/read/24625912/combat-training-stress-in-soldiers-increases-s100b-a-marker-of-increased-blood-brain-barrier-permeability-and-induces-immune-activation
#19
Xinhua Li, Clive H Wilder-Smith, Mary Enci Kan, Jia Lu, Yang Cao, Reuben K Wong
BACKGROUND: Experimental data suggest stress-related cognitive dysfunction may be associated with increased blood-brain-barrier (BBB) permeability secondary to immune activation. METHODS: We investigated the relationship between prolonged and intense physical and psychological combat-training stress, immune activation and blood-brain-barrier permeability in 37 healthy male army medical rapid response troops. RESULTS: Soldiers during intense combat training showed greater self-reported stress, anxiety and depression levels than at rest, as assessed by specific questionnaires...
2014: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/24397543/erythropoietin-pretreatment-suppresses-seizures-and-prevents-the-increase-in-inflammatory-mediators-during-pentylenetetrazole-induced-generalized-seizures
#20
Nesrin Bahçekapılı, Kadriye Akgün-Dar, Işıl Albeniz, Ayşegül Kapucu, Aslı Kandil, Orhan Yağız, Gülay Üzüm
Erythropoietin (EPO) suppresses epileptic seizures, but the mechanism is unclear. The search for novel targets in the therapy of epilepsy has focused recently on brain inflammation since brain inflammation and the associated blood-brain barrier (BBB) damage appears to be an integral part of epilepsy pathophysiology. We examined the effects of EPO on proinflammatory mediators in brain and serum in PTZ-induced generalized seizure model. The inflammation markers (IL-1β, TNF-α, IL-6, IL-10), BBB and neuron damage markers (S100B, Neuron specific enolase; NSE, respectively) in serum and brain of Sprague-Dawley male rats were examined with the ELISA method...
October 2014: International Journal of Neuroscience
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