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https://www.readbyqxmd.com/read/29048513/sepsis-national-hospital-inpatient-quality-measure-sep-1-multistakeholder-work-group-recommendations-for-appropriate-antibiotics-for-the-treatment-of-sepsis
#1
Edward J Septimus, Craig M Coopersmith, Jessica Whittle, Caleb P Hale, Neil O Fishman, Thomas J Kim
The Center for Medicare and Medicaid Services adopted the Early Management Bundle, Severe Sepsis/Septic Shock (SEP-1) performance measure to the Hospital Inpatient Quality Reporting Program in July 2015 to help address the high mortality and high cost associated with sepsis. The SEP-1 performance measure requires, among other critical interventions, timely administration of antibiotics to patients with sepsis or septic shock. The multistakeholder workgroup recognizes the need for SEP-1 but strongly believes that multiple antibiotics listed in the antibiotic tables for SEP-1 are not appropriate and the use of these antibiotics, as called for in the SEP-1 measure, is not in alignment with prudent antimicrobial stewardship...
October 16, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29048364/protective-effect-of-argan-and-olive-oils-against-lps-induced-oxidative-stress-and-inflammation-in-mice-livers
#2
Soufiane El Kamouni, Riad El Kebbaj, Pierre Andreoletti, Abderrahim El Ktaibi, Issam Rharrassi, Abdelkhalid Essamadi, M'hammed Saïd El Kebbaj, Stéphane Mandard, Norbert Latruffe, Joseph Vamecq, Boubker Nasser, Mustapha Cherkaoui-Malki
Sepsis causes severe dysregulation of organ functions, via the development of oxidative stress and inflammation. These pathophysiological mechanisms are mimicked in mice injected with bacterial lipopolysaccharide (LPS). Here, protective properties of argan oil against LPS-induced oxidative stress and inflammation are explored in the murine model. Mice received standard chow, supplemented with argan oil (AO) or olive oil (OO) for 25 days, before septic shock was provoked with a single intraperitoneal injection of LPS, 16 hours prior to animal sacrifice...
October 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29047413/itactic-implementing-treatment-algorithms-for-the-correction-of-trauma-induced-coagulopathy-study-protocol-for-a-multicentre-randomised-controlled-trial
#3
Kjersti Baksaas-Aasen, Lewis Gall, Simon Eaglestone, Claire Rourke, Nicole P Juffermans, J Carel Goslings, Paal Aksel Naess, Susan van Dieren, Sisse Rye Ostrowski, Jakob Stensballe, Marc Maegele, Simon J Stanworth, Christine Gaarder, Karim Brohi, Per I Johansson
BACKGROUND: Traumatic injury is the fourth leading cause of death globally. Half of all trauma deaths are due to bleeding and most of these will occur within 6 h of injury. Haemorrhagic shock following injury has been shown to induce a clotting dysfunction within minutes, and this early trauma-induced coagulopathy (TIC) may exacerbate bleeding and is associated with higher mortality and morbidity. In spite of improved resuscitation strategies over the last decade, current transfusion therapy still fails to correct TIC during ongoing haemorrhage and evidence for the optimal management of bleeding trauma patients is lacking...
October 18, 2017: Trials
https://www.readbyqxmd.com/read/29045749/immune-checkpoint-inhibitor-related-myocarditis
#4
Kazuko Tajiri, Kazutaka Aonuma, Ikuo Sekine
Immune checkpoint inhibitors have demonstrated significant clinical benefit in many cancers. The clinical benefit afforded by these treatments can be accompanied by a unique and distinct spectrum of adverse events. Recently, several fatal cases of immune checkpoint inhibitor-related myocarditis were reported. Although its frequency is comparatively lower than that of other immune-related adverse events, myocarditis can lead to circulatory collapse and lethal ventricular arrhythmia. Immune checkpoints, cytotoxic T-lymphocyte antigen 4 (CTLA-4) and programmed cell death protein 1 (PD-1), play important roles in establishing peripheral tolerance to the heart...
October 17, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29045637/effects-of-feeding-on-different-host-plants-and-diets-on-bradysia-odoriphaga-population-parameters-and-tolerance-to-heat-and-insecticides
#5
Guodong Zhu, Yin Luo, Ming Xue, Haipeng Zhao, Xia Sun, Xinhui Wang, John Trumble
Bradysia odoriphaga Yang et Zhang, the Chinese chive root maggot, is a devastating pest of agricultural plants causing significant losses in vegetable crops, edible mushrooms, and humus. To determine the effects of feeding on different host plants and diets on the life parameters of B. odoriphaga and its tolerance to stressful conditions, we analyzed the life-table data of B. odoriphaga reared on Chinese chive (Allium hookeri), Welsh onion (Allium fistulosum), garlic (Allium sativum), oyster mushroom (Pleurotus ostreatus), and humus and assayed its tolerance to heat and insecticides...
October 17, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29044192/skin-transcriptome-reveals-the-intrinsic-molecular-mechanisms-underlying-hair-follicle-cycling-in-cashmere-goats-under-natural-and-shortened-photoperiod-conditions
#6
Min Yang, Shen Song, Kunzhe Dong, XiaoFei Chen, Xuexue Liu, Marhaba Rouzi, Qianjun Zhao, Xiaohong He, Yabin Pu, Weijun Guan, Yuehui Ma, Lin Jiang
The growth of cashmere exhibits a seasonal pattern arising from photoperiod change. However, the underlying molecular mechanism remains unclear. We profiled the skin transcriptome of six goats at seven time points during hair follicle cycling via RNA-seq. The six goats comprised three goats exposed to a natural photoperiod and three exposed to a shortened photoperiod. During hair cycle transition, 1713 genes showed differential expression, and 332 genes showed a pattern of periodic expression. Moreover, a short photoperiod induced the hair follicle to enter anagen early, and 246 genes overlapped with the periodic genes...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042299/non-pharmacological-interventions-for-spasticity-in-adults-an-overview-of-systematic-reviews
#7
REVIEW
Fary Khan, Bhasker Amatya, Djamel Bensmail, Alain Yelnik
OBJECTIVES: Spasticity causes significant long-term disability-burden, requiring comprehensive management. This review evaluates evidence from published systematic reviews of clinical trials for effectiveness of non-pharmacological interventions for improved spasticity outcomes. METHODS: Data sources: A literature search was conducted using medical and health science electronic (MEDLINE, EMBASE, CINAHL, PubMed, and the Cochrane Library) databases for published systematic reviews up to 15(th) June 2017...
October 14, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29041026/-toxic-shock-syndrome-caused-by-fingertip-injury-management-with-semi-occlusive-dressing
#8
Julia Sproedt, Abdul Rahman Jandali, Rotraud Katharina Saurenmann, Franziska Zucol
No abstract text is available yet for this article.
October 2017: Handchirurgie, Mikrochirurgie, Plastische Chirurgie
https://www.readbyqxmd.com/read/29040883/veno-arterial-extracorporeal-membrane-oxygenation-va-ecmo-for-emergency-cardiac-support
#9
Terri Sun, Andrew Guy, Amandeep Sidhu, Gordon Finlayson, Brian Grunau, Lillian Ding, Saida Harle, Leith Dewar, Richard Cook, Hussein D Kanji
PURPOSE: Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) may provide benefit to patients in refractory cardiac arrest and cardiogenic shock. We aim to summarize our center's 6-year experience with resuscitative VA-ECMO. MATERIALS AND METHODS: A retrospective medical record review (April 2009 to 2015) was performed on consecutive non-cardiotomy patients who were managed with VA-ECMO due to refractory in- or out-of-hospital cardiac (IHCA/OHCA) arrest (E-CPR) or refractory cardiogenic shock (E-CS) with or without preceding cardiac arrest...
October 12, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29040214/untreated-relative-hypotension-measured-as-perfusion-pressure-deficit-during-management-of-shock-and-new-onset-acute-kidney-injury-a-literature-review
#10
Rakshit Panwar
Maintaining an optimal blood pressure (BP) during shock is a fundamental tenet of critical care. Optimal BP targets maybe different for different patients. In current practice, too often, uniform BP targets are pursued which may result in inadvertently accepting a degree of untreated relative hypotension i.e., the deficit between patients' usual pre-morbid basal BP and the achieved BP, during vasopressor support. Relative hypotension is a common but an under-recognized and an under-treated sign among patients with potential shock state...
October 16, 2017: Shock
https://www.readbyqxmd.com/read/29038776/torsion-of-an-accessory-hepatic-lobe-with-embedded-gallbladder-in-an-11-month-old-boy
#11
Chiman Lal Thakral, Ganji Shivalingam, Faizan Manzoor Dar, Nimish Thakral
An accessory lobe of the liver is a rare entity in clinical practice which is diagnosed incidentally. Infrequently, it may present as torsion with a clinical picture of an acute abdomen, a palpable mass, and may be associated with liver function abnormalities. Many of these patients have a history of previous surgery for congenital abdominal wall defects such as omphalocele. We present an extremely rare case of torsion of an accessory hepatic lobe in an 11-month-old male patient who presented in a state of shock...
January 2017: European Journal of Pediatric Surgery Reports
https://www.readbyqxmd.com/read/29035890/biocharacterization-of-heat-shock-protein-90-in-acetaminophen-treated-livers-without-conspicuous-drug-induced-liver-injury
#12
Ka Wu, Chao Guo, Min Su, Xinmou Wu, Rong Li
BACKGROUND/AIMS: Acetaminophen (APAP) refers to a medication used to manage pain and fever symptoms. Heat shock protein 90 (Hsp90) is to be expressed during various stresses, such as wound healing and tissue remodeling. Recently, it is discovered that Hsp90 is a potential modifier of cytogenesis. In comparison to clinical references of liver damage, this study was designed to assess the potential bioeffect of Hsp90 in APAP-treated livers without conspicuous drug induced liver injury (DILI)...
October 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29035427/differences-in-the-korea-acute-myocardial-infarction-registry-compared-with-western-registries
#13
REVIEW
Doo Sun Sim, Myung Ho Jeong
The Korea Acute Myocardial Infarction Registry (KAMIR) is the first nationwide registry that reflects current therapeutic approaches and acute myocardial infarction (AMI) management in Korea. The results of the KAMIR demonstrated different risk factors and responses to medical and interventional treatments. The results indicated that the incidence of ST-elevation myocardial infarction (STEMI) was relatively high, and that the prevalence of dyslipidemia was relatively low with higher triglyceride and lower high-density lipoprotein cholesterol levels...
September 18, 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29031127/patients-perceptions-and-experiences-of-living-with-a-surgical-wound-healing-by-secondary-intention-a-qualitative-study
#14
Dorothy McCaughan, Laura Sheard, Nicky Cullum, Jo Dumville, Ian Chetter
BACKGROUND: Most surgical wounds heal by primary intention, that is to say, the edges of the wound are brought together with sutures, staples, adhesive glue or clips. However, some wounds may be left open to heal (if there is a risk of infection, or if there has been significant tissue loss), and are known as 'surgical wounds healing by secondary intention'. They are estimated to comprise approximately 28% of all surgical wounds and are frequently complex to manage. However, they are under researched and little is known of their impact on patients' lives...
September 28, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29029632/fatal-haemorrhage-and-neoplastic-thrombosis-in-a-captive-african-lion-panthera-leo-with-metastatic-testicular-sex-cord-stromal-tumour
#15
Omar Antonio Gonzales-Viera, Angélica María Sánchez-Sarmiento, Natália Coelho Couto de Azevedo Fernandes, Juliana Mariotti Guerra, Rodrigo Albergaria Ressio, José Luiz Catão-Dias
BACKGROUND: The study of neoplasia in wildlife species contributes to the understanding of cancer biology, management practices, and comparative pathology. Higher frequencies of neoplasms among captive non-domestic felids have been reported most commonly in aging individuals. However, testicular tumours have rarely been reported. This report describes a metastatic testicular sex cord-stromal tumour leading to fatal haemorrhage and thrombosis in a captive African lion (Panthera leo). CASE PRESENTATION: During necropsy of a 16-year-old male African lion, the left testicle and spermatic cord were found to be intra-abdominal (cryptorchid), semi-hard and grossly enlarged with multiple pale-yellow masses...
October 13, 2017: Acta Veterinaria Scandinavica
https://www.readbyqxmd.com/read/29026893/descending-necrotizing-mediastinitis-after-a-trigger-point-injection
#16
Jae Young Choe, Jong Kun Kim, Dong Eun Lee, Kang Suk Seo, Jung Bae Park, Mi Jin Lee, Hyun Wook Ryoo, Jae Yun Ahn, Sungbae Moon
Descending necrotizing mediastinitis (DNM) is a rare form of mediastinal infection. Most cases are associated with esophageal rupture. DNM after a trigger point injection in the upper trapezius has not been described previously. We present a case of DNM after a trigger point injection in the upper trapezius. A 70-year-old man visited the emergency department with chest discomfort and fever after a trigger point injection in the left upper trapezius. Chest computed tomography showed evidence of DNM, and antibiotic therapy was immediately administered intravenously...
September 2017: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/29026736/giant-duplication-cyst-presenting-as-a-discharging-umbilicus
#17
Ravi Kumar Garg, Monika Bawa, Katragadda Lakshmi Narasimha Rao
Alimentary tract duplication cysts are rare congenital anomalies, most commonly located in the ileum, but may present anywhere from mouth to anus.Clinically, they may be asymptomatic, incidentally diagnosed or may present with obstruction, volvulus, intussusception or gastrointestinal bleed. Here we report a case of a one year old male child presenting in gasping state and shock. Despite the initial strong suspicion of Meckel's diverticulum and tubercular abdomen, the final diagnosis remained elusive till exploratory laparotomy was performed which revealed a duplication cyst of ileum with perforation into the umbilicus...
September 2017: Pediatric Gastroenterology, Hepatology & Nutrition
https://www.readbyqxmd.com/read/29024269/fluid-resuscitation-in-patients-with-severe-burns-a-meta-analysis-of-randomized-controlled-trials
#18
Yuan Kao, El-Wui Loh, Chien-Chin Hsu, Hung-Jung Lin, Chien-Cheng Huang, Yun-Yun Chou, Chieh-Chun Lien, Ka-Wai Tam
OBJECTIVES: Fluid resuscitation is the mainstay treatment to reconstitute intravascular volume and maintain end-organ perfusion in patients with severe burns. The use of a hyper-osmotic or iso-osmotic solution in fluid resuscitation to manage myocardial depression and increased capillary permeability during burn shock has been debated. We conducted a systematic review and meta-analysis to compare the efficacies of hyper-osmotic and iso-osmotic solutions in restoring hemodynamic stability after burn injuries...
October 11, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29019796/monitoring-modalities-and-assessment-of-fluid-status-a-practice-management-guideline-from-the-eastern-association-for-the-surgery-of-trauma-east
#19
David S Plurad, William Chiu, Ali S Raja, Samuel M Galvagno, Uzer Khan, Dennis Y Kim, Samuel A Tisherman, Jeremy Ward, Mark E Hamill, Vicki Bennett, Brian Williams, Bryce Robinson
BACKGROUND: Fluid administration in critically ill surgical patients must be closely monitored to avoid complications. Resuscitation guided by invasive methods are not consistently associated with improved outcomes. As such, there has been increased use of Focused Ultrasound and Arterial Pulse Waveform Analysis (APWA) to monitor and aid resuscitation. An assessment of these methods using the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) framework is presented...
October 11, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29019055/psychological-distress-and-coping-strategies-among-women-with-incurable-lung-cancer-a-qualitative-study
#20
Yu-Chien Liao, Wei-Yu Liao, Jia-Ling Sun, Jen-Chung Ko, Chong-Jen Yu
PURPOSE: Limited research has focused on women with lung cancer (LC) although they are recognized as the most vulnerable to psychological distress. This study explored in-depth the psychological distress experienced by women with incurable LC and analyzed the coping strategies with which they manage that distress. METHODS: A qualitative methodology with in-depth interviews was employed for 34 women with advanced or recurrent LC. An inductive data-driven thematic analysis was applied to analyze transcripts...
October 10, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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