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Barbara Deal

Daryl Evans, Barbara Nowak
Melanomacrophage centres (MMCs) are common in the haemopoietic tissue of fish and are an important component of the humoral immune response. Increasingly they are being studied as a biomarker of environmental stress in both wild and aquaculture fish stocks. Computer image analysis of histological sections of the head kidney and spleen of ranched Southern bluefin tuna (SBT) was used to investigate changes in MMCs over various stages of the ranching cycle. Histochemical pigment differentiation indicated haemosiderin, lipofuscin and melanin were present in MMCs of both the kidney and spleen, with kidney MMCs being highly positive for lipofuscin and melanin and spleen having high levels of haemosiderin and a lower level of melanin than kidney...
December 2016: Fish & Shellfish Immunology
Seong Jae Hwang, Nagesh Adluru, Maxwell D Collins, Sathya N Ravi, Barbara B Bendlin, Sterling C Johnson, Vikas Singh
There is a great deal of interest in using large scale brain imaging studies to understand how brain connectivity evolves over time for an individual and how it varies over different levels/quantiles of cognitive function. To do so, one typically performs so-called tractography procedures on diffusion MR brain images and derives measures of brain connectivity expressed as graphs. The nodes correspond to distinct brain regions and the edges encode the strength of the connection. The scientific interest is in characterizing the evolution of these graphs over time or from healthy individuals to diseased...
June 2016: Proceedings
Nicole Maeding, Thomas Verwanger, Barbara Krammer
Photodynamic therapy (PDT) is a cancer treatment with a long-standing history. It employs the application of nontoxic components, namely a light-sensitive photosensitizer and visible light, to generate reactive oxygen species (ROS). These ROS lead to tumor cell destruction, which is accompanied by the induction of an acute inflammatory response. This inflammatory process sends a danger signal to the innate immune system, which results in activation of specific cell types and release of additional inflammatory mediators...
October 6, 2016: Cancers
Anna-Barbara Schlüer
While the problem of Pressure Ulcers (PU) in adults has received a great deal of attention, far less is known about PUs in neonates and children. The overall health status of children is generally better and multi-morbidity is limited to a small percentage of patients, like very low term neonates (born before 32 weeks of gestation age), newborns with congenital abnormalities, genetic disorders, perinatal distress syndrome or children with a limited immunity. Survival rates of both critically and chronically ill neonates, infants and children have improved dramatically in recent years, introducing new challenges for medical and nursing care...
October 8, 2016: Journal of Tissue Viability
Małgorzata Białous, Vitalii Yunko, Szymon Bauch, Michał Ławniczak, Barbara Dietz, Leszek Sirko
We present experimental studies of the power spectrum and other fluctuation properties in the spectra of microwave networks simulating chaotic quantum graphs with violated time reversal invariance. On the basis of our data sets, we demonstrate that the power spectrum in combination with other long-range and also short-range spectral fluctuations provides a powerful tool for the identification of the symmetries and the determination of the fraction of missing levels. Such a procedure is indispensable for the evaluation of the fluctuation properties in the spectra of real physical systems like, e...
September 30, 2016: Physical Review Letters
Constantine Mavroudis, Barbara J Deal
Certain congenital heart anomalies make patients more susceptible to arrhythmia development throughout their lives. This poses the question whether prophylactic arrhythmia surgery should be incorporated into reparative open heart procedures for congenital heart disease. There is currently no consensus on what constitutes a standard prophylactic procedure, owing to the questions that remain regarding lesions to be performed; energy sources to use; proximity of energy source or incisions to coronary arteries, sinoatrial node, atrioventricular node; circumstances for right atrial, left atrial, or biatrial appendectomy; and whether to perform a right, left, or biatrial maze procedure...
July 2016: Translational pediatrics
Mar Fernández-Gutiérrez, Marta Rodriguez-Mancheño, Bárbara Pérez-Köhler, Gemma Pascual, Juan Manuel Bellón, Julio San Román
The article deals with a comparative analysis of the parameters of the polymerization in physiological conditions of three commercially available alkyl cyanoacrylates, n-butyl cyanoacrylate (GLUBRAN 2), n-hexyl cyanoacrylate (IFABOND), and n-octyl cyanoacrylate (EVOBOND), the cell behavior of the corresponding polymers and the application of these adhesives in the fixation of surgical polypropylene meshes for hernia repair in an animal model of rabbits. The results obtained demonstrate that the curing process depends on the nature of the alkyl residue of the ester group of cyanoacrylate molecules, being the heat of polymerization lower for the octyl derivative in comparison with the hexyl and butyl, and reaching a maximum temperature of 35 °C after a time of mixing with physiological fluids of 60-70 s...
October 5, 2016: Macromolecular Bioscience
Barbara Rita Porchia, Paolo Bonanni, Angela Bechini, Gugliemo Bonaccorsi, Sara Boccalini
Pneumococcal infection is a public health concern that disproportionately affects the young, the elderly, and the immunocompromised. There is an open debate on the implementation of polysaccharide and/or conjugate vaccines for pneumococcal diseases in adults and the elderly in many countries. The aim of this paper is to systematically review the economic profile of pneumococcal vaccines in adults in terms of costs and benefits. Areas covered: The search for economic studies on pneumococcal vaccination was carried out in Pubmed, Embase, Scopus, and the HTA and NHS EED databases and through a manual search in journals dealing with economic evaluations...
October 12, 2016: Expert Review of Vaccines
Pierre Le Cann, Hélène Paulus, Philippe Glorennec, Barbara Le Bot, Sophie Frain, Jean Pierre Gangneux
Home health care workers interventions have been implemented in western countries to improve health status of patients with respiratory diseases especially asthma and allergic illnesses. Twenty-six controlled studies dealing with prevention and control of these diseases through home environmental interventions were reviewed. After a comprehensive description of the characteristics of these studies, the effectiveness of each intervention was then evaluated in terms of participants' compliance with the intervention program, improvement of quality of the indoor environment, and finally improvement of health outcomes, in detailed tables...
September 21, 2016: Journal of Allergy and Clinical Immunology in Practice
Henryk T Flakus, Barbara Hachuła, Jakub T Hołaj-Krzak, Faisal A Al-Agel, Najeh Rekik
This paper deals with the experimental and theoretical studies of abnormal properties of terephthalic acid (TAC) and phthalic acid (PAC) crystals manifested in the H/D isotopic exchange. The widely utilized deuteration routine appeared to be insufficiently effective in the case of the h6-TAC isotopomer. In the case of the d4-TAC derivative the isotopic exchange process occurred noticeably more effectively. In contrast, both isotopomers of PAC, h6 and d4, appeared much more susceptible for deuteration. A theoretical model was elaborated describing "long-distance" dynamical co-operative interactions involving hydrogen bonds in TAC and PAC crystals...
August 29, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Angela M Barbara, Maureen Dobbins, R Brian Haynes, Alfonso Iorio, John N Lavis, Anthony J Levinson
BACKGROUND: Evidence summaries and blogs can support evidence-informed healthy aging, by presenting high-quality health research evidence in plain language for a nonprofessional (citizen) audience. OBJECTIVE: Our objective was to explore citizens' perceptions about the usability of evidence summaries and blog posts on the Web-based McMaster Optimal Aging Portal. METHODS: Twenty-two citizens (aged 50 years and older) and informal caregivers participated in a qualitative study using a think-aloud method and semistructured interviews...
2016: JMIR Human Factors
Barbara Gardella, Anna Daniela Iacobone, Valentina Musacchi, Isabel Giacoma Calvino, Mara De Amici, Cristina Torre, Stefano Bogliolo, Arsenio Spinillo
OBJECTIVES: The purpose of the study was to evaluate the mucosal immune response in women affected by primary human papillomavirus (HPV) infection, in comparison with HPV-negative women with no previous history of HPV. METHODS: A case-control study comparing the activity of myeloperoxidase (MPO) and lactoferrin (LF) between 19 HPV-positive and 19 HPV-negative women matched for age. Plasmatic and cervicovaginal levels of polymorphonuclear neutrophils (PMN) exhibiting MPO and LF receptors were measured using cytofluorimetric analysis and expressed as mean of percentages...
October 2016: Journal of Lower Genital Tract Disease
Stefano Negrini, Barbara Piovanelli, Cinzia Amici, Valter Cappellini, Gabriele Bovi, Maurizio Ferrarin, Fabio Zaina, Alberto Borboni
INTRODUCTION: This systematic literature review aims to check the current state of affairs of non-gait-related optoelectronic trunk movement analysis; results have been analyzed from a clinical and a methodological perspective. EVIDENCE ACQUISITION: Extensive research was performed on all papers published until December 31st, 2015, dealing with trunk movement analysis assessed by optoelectronic systems, excluding those related to gait. The research was performed on the 14th of January 2016 on three databases: Scopus, Science Direct and Pubmed...
August 2016: European Journal of Physical and Rehabilitation Medicine
Silvia Cascianelli, Michele Scialpi, Serena Amici, Nevio Forini, Matteo Minestrini, Mario Luca Fravolini, Helmut Sinzinger, Orazio Schillaci, Barbara Palumbo
Artificial Intelligence (AI) is a very active Computer Science research field aiming to develop systems that mimic human intelligence and is helpful in many human activities, including Medicine. In this review we presented some examples of the exploiting of AI techniques, in particular automatic classifiers such as Artificial Neural Network (ANN), Support Vector Machine (SVM), Classification Tree (ClT) and ensemble methods like Random Forest (RF), able to analyze findings obtained by positron emission tomography (PET) or single-photon emission tomography (SPECT) scans of patients with Neurodegenerative Diseases, in particular Alzheimer's Disease...
June 20, 2016: Current Alzheimer Research
Renata Dyja, Barbara Dolińska, Florian Ryszka
The paper deals with the results of an investigation of the release of selected amino acids (histidine, tryptophan, tyrosine) from model suspensions prepared by co-precipitation with zinc chloride. It has been proven that the influence of the Zn(II)/amino acid molar ratio on dissolution profiles of the tested amino acids and dissolution half-life (t1/2) of histidine or tryptophan is significant. The amount of amino acid in the dispersed phase (supporting dose) is a determinant of the amino acid release profile...
June 1, 2016: Acta Pharmaceutica
Mary O'Brien, Jennifer Kirton, Katherine Knighting, Brenda Roe, Barbara Jack
BACKGROUND: There are approximately 426,000 people residing within care homes in the UK. Residents often have complex trajectories of dying, which make it difficult for staff to manage their end-of-life care. There is growing recognition for the need to support care homes staff in the care of these residents with increased educational initiatives. One educational initiative is The Six Steps to Success programme. METHOD: In order to evaluate the implementation of Six Steps with the first cohort of care homes to complete the end-of-life programme in the North West of England...
2016: BMC Palliative Care
Maria Conceição Reisinho, Bárbara Gomes
UNLABELLED: Theme: Complex health care and chronic disease management. INTRODUCTION: The adolescent with cystic fibrosis suffers from organic distresses and requires support to deal with the physical symptoms and the psychosocial adaptation. AIM: Realize the experience of growing up with cystic fibrosis from the adolescent point of view. METHODOLOGY: Data grounded theory as investigation method and interpretation by Meleis Theory...
May 9, 2016: Nursing Children and Young People
Barbara L Filkins, Ju Young Kim, Bruce Roberts, Winston Armstrong, Mark A Miller, Michael L Hultner, Anthony P Castillo, Jean-Christophe Ducom, Eric J Topol, Steven R Steinhubl
The rapid growth in the availability and incorporation of digital technologies in almost every aspect of our lives creates extraordinary opportunities but brings with it unique challenges. This is especially true for the translational researcher, whose work has been markedly enhanced through the capabilities of big data aggregation and analytics, wireless sensors, online study enrollment, mobile engagement, and much more. At the same time each of these tools brings distinctive security and privacy issues that most translational researchers are inadequately prepared to deal with despite accepting overall responsibility for them...
2016: American Journal of Translational Research
Jason Y Cheng, Holly Ning, Barbara C Arora, Ying Zhuge, Robert W Miller
The dose measurements of the small field sizes, such as conical collimators used in stereotactic radiosurgery (SRS), are a significant challenge due to many factors including source occlusion, detector size limitation, and lack of lateral electronic equilibrium. One useful tool in dealing with the small field effect is Monte Carlo (MC) simulation. In this study, we report a comparison of Monte Carlo simulations and measurements of output factors for the Varian SRS system with conical collimators for energies of 6 MV flattening filter-free (6 MV) and 10 MV flattening filter-free (10 MV) on the TrueBeam accelerator...
2016: Journal of Applied Clinical Medical Physics
Marek Przybylski, Dariusz Kapelski, Barbara Ślusarek, Sławomir Wiak
Magnetization of large Nd-Fe-B sintered permanent magnets is still challenging. This type of permanent magnet is electrically conductive, so impulse magnetization causes a flow of eddy currents which prevent magnetization of the whole volume of the magnet. The paper deals with the impulse magnetization of sintered Nd-Fe-B permanent magnets and shows a method for the determination of suitable parameters for the supply system. The necessary magnetic field strength for magnetization of the magnet to saturation was determined...
2016: Sensors
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