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Barbara Deal

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https://www.readbyqxmd.com/read/28696918/gold-nanorods-induce-early-embryonic-developmental-delay-and-lethality-in-zebrafish-danio-rerio
#1
Bárbara Mesquita, Isabel Lopes, Susana Silva, Maria João Bessa, Maksim Starykevich, Jorge Carneiro, Tiago L P Galvão, Mário G S Ferreira, João Tedim, João Paulo Teixeira, Sónia Fraga
Due to their unique electronic and optical features, gold nanoparticles (AuNP) have received a great deal of attention for application in different fields such as catalysis, electronics, and biomedicine. The large-volume manufacturing predicted for future decades and the inevitable release of these substances into the environment necessitated an assessment of potential adverse human and ecological risks due to exposure to AuNP. Accordingly, this study aimed to examine the acute and developmental toxicity attributed to a commercial suspension of Au nanorods stabilized with cetyltrimethylammonium bromide (CTAB-AuNR) using early embryonic stages of zebrafish (Danio rerio), a well-established model in ecotoxicology...
July 11, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28687858/a-genomic-perspective-on-hla-evolution
#2
REVIEW
Diogo Meyer, Vitor R C Aguiar, Bárbara D Bitarello, Débora Y C Brandt, Kelly Nunes
Several decades of research have convincingly shown that classical human leukocyte antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many questions remain regarding the type of selective regime acting on these loci, the time frame at which selection acts, and the functional connections between genetic variability and natural selection. In this review, we argue that genomic datasets, in particular those generated by next-generation sequencing (NGS) at the population scale, are transforming our understanding of HLA evolution...
July 7, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28667894/examining-how-different-measurement-approaches-impact-safety-outcomes-in-child-pedestrian-research-implications-for-research-and-prevention
#3
Michael R Corbett, Barbara A Morrongiello
There has been a great deal of research aimed at understanding the causes of child pedestrian injury. Many different methods have been employed with the goal of designing simulations that produce rigorous assessment of children's behaviors without putting children at risk of actual pedestrian injury. Most research has assessed children's pre-crossing decision making and extrapolated crossing outcome measures from estimates of mean walking speed. This study explores the nature and extent of measurement bias that is introduced when average walking speed is used to produce estimates of outcomes versus measuring actual in-road behavior directly...
June 28, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28666782/how-bonobo-communities-deal-with-fruits-containing-high-tannin-content-re-ingestion-and-other-feeding-processes
#4
David Beaune, Gottfried Hohmann, Adeline Serckx, Tetsuya Sakamaki, Victor Narat, Barbara Fruth
This report describes bonobo (Pan paniscus, Hominidae) behavioral flexibility and inter-community differences in with high tannin level fruit processing. In fruiting plants, tannin should discourage certain seed dispersers (direct deterrence hypothesis) such as primates. Based on data deriving from five study sites; LuiKotale, Lomako, Wamba, Malebo and Manzano, we compare consumption and dispersal of fruit species rich in tannins: Parinari and Musanga pulp was chewed across all communities probably for saliva tannin neutralisation...
June 27, 2017: Behavioural Processes
https://www.readbyqxmd.com/read/28651293/-tuberculosis-guideline-for-adults-guideline-for-diagnosis-and-treatment-of-tuberculosis-including-ltbi-testing-and-treatment-of-the-german-central-committee-dzk-and-the-german-respiratory-society-dgp
#5
Tom Schaberg, Torsten Bauer, Folke Brinkmann, Roland Diel, Cornelia Feiterna-Sperling, Walter Haas, Pia Hartmann, Barbara Hauer, Jan Heyckendorf, Christoph Lange, Albert Nienhaus, Ralf Otto-Knapp, Martin Priwitzer, Elvira Richter, Rudolf Rumetshofer, Karl Schenkel, Otto Dagobert Schoch, Nicolas Schönfeld, Ralf Stahlmann
Since 2015 a significant increase in tuberculosis cases is notified in Germany, mostly due to rising numbers of migrants connected to the recent refugee crisis. Because of the low incidence in previous years, knowledge on tuberculosis is more and more limited to specialized centers. However, lung specialist and healthcare workers of other fields have contact to an increasing number of tuberculosis patients. In this situation, guidance for the management of standard therapy and especially for uncommon situations will be essential...
June 2017: Pneumologie
https://www.readbyqxmd.com/read/28636879/delineating-neuroinflammation-parasite-cns-invasion-and-blood-brain-barrier-dysfunction-in-an-experimental-murine-model-of-human-african-trypanosomiasis
#6
Jean Rodgers, Barbara Bradley, Peter G E Kennedy
Although Trypanosoma brucei spp. was first detected by Aldo Castellani in CSF samples taken from sleeping sickness patients over a century ago there is still a great deal of debate surrounding the timing, route and effects of transmigration of the parasite from the blood to the CNS. In this investigation, we have applied contrast-enhance magnetic resonance imaging (MRI) to study the effects of trypanosome infection on the blood-brain barrier (BBB) in the well-established GVR35 mouse model of sleeping sickness...
June 18, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28627221/management-and-family-burdens-endorsed-by-parents-of-youth-7-years-old-with-type-1-diabetes
#7
Kara Harrington, Claire T Boyle, Kellee M Miller, Marisa E Hilliard, Barbara J Anderson, Michelle Van Name, Linda A DiMeglio, Lori M Laffel
BACKGROUND: This study investigated unique burdens experienced by parents of young children with type 1 diabetes in the context of contemporary diabetes management. METHODS: Self-report surveys and medical record information from the T1D Exchange clinic registry were used. Parental burden and family impact scores were tabulated across demographic and clinical characteristics, overall and according to age group (<4, 4-<6, and 6-<7 years). RESULTS: The mean age of the 549 children was 5...
February 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28609258/widowed-parenting-self-efficacy-scale-a-new-measure
#8
Teresa P Edwards, Justin M Yopp, Eliza M Park, Allison Deal, Barbara B Biesecker, Donald L Rosenstein
The authors developed and tested a novel measure of parenting self-efficacy specifically for recently widowed parents of dependent-age children. They tested the scale among 244 recently widowed fathers via an open-access web survey. Exploratory factor analysis identified 3 factors: perception of meeting parenting expectations (α = .88), provision of effective discipline (α = .69), and sense of parental burden (α = .69). Scores on the new scale correlated positively with Kansas Parenting Satisfaction and Psychological Adaptation Scale scores, and negatively with CES-D (depression) and TRIG (grief) scale scores...
June 13, 2017: Death Studies
https://www.readbyqxmd.com/read/28597909/diagnostic-and-therapeutic-guidelines-for-gastro-entero-pancreatic-neuroendocrine-neoplasms-recommended-by-the-polish-network-of-neuroendocrine-tumours
#9
Beata Kos-Kudła, Jolanta Blicharz-Dorniak, Janusz Strzelczyk, Agata Bałdys-Waligórska, Tomasz Bednarczuk, Marek Bolanowski, Agnieszka Boratyn-Nowicka, Małgorzata Borowska, Andrzej Cichocki, Jarosław B Ćwikła, Massimo Falconi, Wanda Foltyn, Daria Handkiewicz-Junak, Alicja Hubalewska-Dydejczyk, Barbara Jarząb, Roman Junik, Dariusz Kajdaniuk, Grzegorz Kamiński, Agnieszka Kolasińska-Ćwikła, Aldona Kowalska, Robert Król, Leszek Królicki, Maciej Krzakowski, Jolanta Kunikowska, Katarzyna Kuśnierz, Paweł Lampe, Dariusz Lange, Anna Lewczuk-Myślicka, Andrzej Lewiński, Michał Lipiński, Magdalena Londzin-Olesik, Bogdan Marek, Anna Nasierowska-Guttmejer, Sergiusz Nawrocki, Ewa Nowakowska-Duława, Joanna Pilch-Kowalczyk, Violetta Rosiek, Marek Ruchała, Lucyna Siemińska, Anna Sowa-Staszczak, Teresa Starzyńska, Katarzyna Steinhof-Radwańska, Krzysztof Sworczak, Anhelli Syrenicz, Andrzej Szawłowski, Marek Szczepkowski, Ewa Wachuła, Wojciech Zajęcki, Anna Zemczak, Wojciech Zgliczyński, Krzysztof Zieniewicz
Progress in the diagnostics and therapy of gastro-entero-pancreatic (GEP) neuroendocrine neoplasms (NEN), the published results of new randomised clinical trials, and the new guidelines issued by the European Neuroendocrine Tumour Society (ENETS) have led the Polish Network of Neuroendocrine Tumours to update the 2013 guidelines regarding management of these neoplasms. We present the general recommendations for the management of NENs, developed by experts during the Third Round Table Conference - Diagnostics and therapy of gastro-entero-pancreatic neuroendocrine neoplasms: Polish recommendations in view of current European recommenda-tions, which took place in December 2016 in Żelechów near Warsaw...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28586942/-drawing-up-a-guideline-for-handling-information-and-communication-technology-flexibility-and-availability-in-small-and-medium-enterprises
#10
Veronika Weilnhammer, Stefanie Heinze, Barbara Heiden, Esther Palm, Britta Herbig, Gabriele Lüke, Dennis Nowak, Jürgen Glaser, Caroline Eva Wella Herr
Background Within the last decades the world of work has changed enormously. Due to new Information and Communication Technologies (ICT), working at any time from any place has become possible. Flexibility, availability and the dissolution of boundaries between work and private life are the possible results of this development. The spread of this development and possible consequences on the affected employee's health and wellbeing have been examined so far especially in big companies. Small and medium-sized enterprises (SME) are rarely subjects of scientific studies in this context...
June 6, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28557942/beyond-selection-the-use-of-situational-judgement-tests-in-the-teaching-and-assessment-of-professionalism
#11
Barbara D Goss, Anna T Ryan, Joshua Waring, Terry Judd, Neville G Chiavaroli, Richard Charles O'Brien, Stephen C Trumble, Geoffrey J McColl
PROBLEM: Professionalism is a critical attribute of medical graduates. Its measurement is challenging. The authors sought to assess final-year medical students' knowledge of appropriate professional behavior across a broad range of workplace situations. APPROACH: Situational judgement tests (SJTs) are used widely in applicant selection to assess judgement or decision making in work-related settings as well as attributes such as empathy, integrity, and resilience...
June 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28546900/response-to-kruse-plass-et-al-2017-regarding-the-risk-to-non-target-lepidopteran-larvae-exposed-to-pollen-from-one-or-more-of-three-bt-maize-events-mon810-bt11-and-1507
#12
Joe N Perry, Paolo Barberi, Detlef Bartsch, A N E Birch, Achim Gathmann, Jozsef Kiss, Barbara Manachini, Marco Nuti, Stefan Rauschen, Joachim Schiemann, Mechthild Schuppener, Jeremy Sweet, Christoph C Tebbe, Fabio Veronesi
We respond to the paper of Kruse-Plass et al. (Environ Sci Eur 29:12, 2017), published in this journal, regarding the risk to non-target lepidopteran larvae exposed to pollen from one or more of three Bt maize events (MON810, Bt11 and 1507). We emphasise that what is important for environmental risk assessment is not the number of pollen grains per se, but the degree of exposure of a NT lepidopteran larva to Bt protein contained in maize pollen. The main text of this response deals with general issues which Kruse-Plass et al...
2017: Environmental Sciences Europe
https://www.readbyqxmd.com/read/28545819/comparative-approaches-to-understanding-thyroid-hormone-regulation-of-neurogenesis
#13
REVIEW
Jean-David Gothié, Barbara Demeneix, Sylvie Remaud
Thyroid hormone (TH) signalling, an evolutionary conserved pathway, is crucial for brain function and cognition throughout life, from early development to ageing. In humans, TH deficiency during pregnancy alters offspring brain development, increasing the risk of cognitive disorders. How TH regulates neurogenesis and subsequent behaviour and cognitive functions remains a major research challenge. Cellular and molecular mechanisms underlying TH signalling on proliferation, survival, determination, migration, differentiation and maturation have been studied in mammalian animal models for over a century...
May 22, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28527859/tackling-influenza-with-broadly-neutralizing-antibodies
#14
REVIEW
Davide Corti, Elisabetta Cameroni, Barbara Guarino, Nicole L Kallewaard, Qing Zhu, Antonio Lanzavecchia
Monoclonal antibodies have revolutionized the treatment of several human diseases, including cancer, autoimmunity and inflammatory conditions and represent a new frontier for the treatment of infectious diseases. In the last decade, new methods have allowed the efficient interrogation of the human antibody repertoire from influenza immune individuals and the isolation of several monoclonal antibodies capable of dealing with the high variability of influenza viruses. Here, we will provide a comprehensive overview of the specificity, antiviral and immunological mechanisms of action and development into the clinic of broadly reactive monoclonal antibodies against influenza A and B viruses...
May 18, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28502592/matrix-metalloproteinases-as-regulators-of-inflammatory-processes
#15
REVIEW
Barbara Fingleton
Inflammation is a central mechanism for dealing with insults to tissue, either from pathogenic invaders or by other damage-inducing means, such that the threat is removed, the tissue is healed and there is a return to homeostasis. It is a multi-step process with manifold methods of regulation built in. Proteolysis is one such regulatory method and members of the matrix metalloproteinase (MMP) family of proteinases have been shown to influence inflammation in myriad of ways. It is becoming more and more clear that no single MMP can be unequivocally labeled as 'good' or 'bad' when considering inflammation in general - the net result of proteolytic activity is dependent on context...
May 11, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28457246/arrhythmia-surgery-for-adults-with-congenital-heart-disease
#16
REVIEW
Barbara J Deal, Constantine Mavroudis
Patients with repaired or unrepaired congenital heart anomalies are at increased risk for arrhythmia development throughout their lives, often paralleling the need for reoperations for hemodynamic residua. The ability to incorporate arrhythmia surgery into reoperations can result in improvement in functional class and decreased need for antiarrhythmic medications. Every reoperation for congenital heart disease can be viewed as an opportunity to assess the electrical and arrhythmia substrates and to intervene to improve the arrhythmias and the hemodynamic condition of the patient...
June 2017: Cardiac Electrophysiology Clinics
https://www.readbyqxmd.com/read/28330941/nurse-driven-clinical-pathway-for-inpatient-asthma-a-randomized-controlled-trial
#17
Catherine M Pound, Victoria Gelt, Salwa Akiki, Kaylee Eady, Katherine Moreau, Franco Momoli, Barbara Murchison, Roger Zemek, Brett Mulholland, Tom Kovesi
OBJECTIVE: We examined the impact of a nurse-driven clinical pathway on length of stay (LOS) for children hospitalized with asthma. METHODS: We conducted a randomized controlled trial involving children hospitalized with asthma. Nurses of children in the intervention group weaned salbutamol frequency using an asthma scoring tool, whereas physicians weaned salbutamol frequency for the control group patients as per standard care. The primary outcome was LOS in hours...
April 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28316351/air-contamination-by-mercury-emissions-and-transformations-a-review
#18
Barbara Gworek, Wojciech Dmuchowski, Aneta H Baczewska, Paulina Brągoszewska, Olga Bemowska-Kałabun, Justyna Wrzosek-Jakubowska
The present and future air contamination by mercury is and will continue to be a serious risk for human health. This publication presents a review of the literature dealing with the issues related to air contamination by mercury and its transformations as well as its natural and anthropogenic emissions. The assessment of mercury emissions into the air poses serious methodological problems. It is particularly difficult to distinguish between natural and anthropogenic emissions and re-emissions from lands and oceans, including past emissions...
2017: Water, Air, and Soil Pollution
https://www.readbyqxmd.com/read/28297351/output-factor-comparison-of-monte-carlo-and-measurement-for-varian-truebeam-6-mv-and-10-mv-flattening-filter-free-stereotactic-radiosurgery-system
#19
Jason Y Cheng, Holly Ning, Barbara C Arora, Ying Zhuge, Robert W Miller
The dose measurements of the small field sizes, such as conical collimators used in stereotactic radiosurgery (SRS), are a significant challenge due to many factors including source occlusion, detector size limitation, and lack of lateral electronic equilibrium. One useful tool in dealing with the small field effect is Monte Carlo (MC) simulation. In this study, we report a comparison of Monte Carlo simulations and measurements of output factors for the Varian SRS system with conical collimators for energies of 6 MV flattening filter-free (6 MV) and 10 MV flattening filter-free (10 MV) on the TrueBeam accelerator...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28295785/improving-support-and-education-of-low-income-baby-boomers-diagnosed-with-chronic-hepatitis-c-virus-infection-through-universal-screening
#20
Barbara J Turner, Kathryn Craig, Vidhi S Makanji, Bertha E Flores, Ludivina Hernandez
AIMS AND OBJECTIVES: To identify support needs of low-income baby boomers recently diagnosed with chronic hepatitis C virus infection. BACKGROUND: The U.S. Preventive Services Task Force has endorsed one-time screening of all baby boomers (born 1945-1965) for hepatitis C because 75% of the estimated 2-3 million persons with chronic infection are in this age range. We hypothesised that persons diagnosed by routine screening would have significant psycho-emotional, cognitive and healthcare challenges that need to be met by collaborative care and services from nurses and other healthcare personnel...
March 15, 2017: Journal of Clinical Nursing
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