keyword
https://read.qxmd.com/read/38492780/the-unusual-kinetics-of-lactate-dehydrogenase-of-schistosoma-mansoni-and-their-role-in-the-rapid-metabolic-switch-after-penetration-of-the-mammalian-host
#1
JOURNAL ARTICLE
Michiel L Bexkens, Olivier M F Martin, Jos M van den Heuvel, Marion G J Schmitz, Bas Teusink, Barbara M Bakker, Jaap J van Hellemond, Jurgen R Haanstra, Malcolm D Walkinshaw, Aloysius G M Tielens
Lactate dehydrogenase (LDH) from Schistosoma mansoni has peculiar properties for a eukaryotic LDH. Schistosomal LDH (SmLDH) isolated from schistosomes, and the recombinantly expressed protein, are strongly inhibited by ATP, which is neutralized by fructose-1,6-bisphosphate (FBP). In the conserved FBP/anion binding site we identified two residues in SmLDH (Val187 and Tyr190) that differ from the conserved residues in LDHs of other eukaryotes, but are identical to conserved residues in FBP-sensitive prokaryotic LDHs...
March 14, 2024: International Journal for Parasitology
https://read.qxmd.com/read/38428258/a-polyphenol-rich-a%C3%A3-a%C3%A3-seed-extract-protects-against-5-fluorouracil-induced-intestinal-mucositis-in-mice-through-the-tlr-4-myd88-pi3k-mtor-nf-%C3%AE%C2%BAbp65-signaling-pathway
#2
JOURNAL ARTICLE
Carlos Eduardo da Silva Monteiro, Bárbara de Cerqueira Fiorio, Francisca Géssica Oliveira Silva, Maria de Fathima Felipe de Souza, Álvaro Xavier Franco, Marcos Aurélio de Sousa Lima, Thiago Meneses Araujo Leite Sales, Tiago Santos Mendes, Alexandre Havt, André Luiz Reis Barbosa, Ângela Castro Resende, Roberto Soares de Moura, Marcellus Henrique Loiola Ponte de Souza, Pedro Marcos Gomes Soares
Açaí seed extract (ASE) is obtained from Euterpe oleracea Mart. (açaí) plant (Amazon region) has high nutritional and functional value. ASE is rich in polyphenolic compounds, mainly proanthocyanidins. Proanthocyanidins can modulate the immune system and oxidative stress by inhibiting the toll-like receptor-4 (TLR-4)/myeloid differentiation primary response 88 (MyD88)/nuclear factor-κB (NF-κB) pathway. A great deal of evidence suggests that inflammatory cytokines and oxidative stress contribute to the pathogenesis of intestinal mucositis, and these events can lead to intestinal dysmotility...
February 3, 2024: Nutrition Research
https://read.qxmd.com/read/38389453/missing-outcome-data-in-recent-perinatal-and-neonatal-clinical-trials
#3
JOURNAL ARTICLE
Guowei Li, Yingxin Liu, Jingyi Zhang, Sara B DeMauro, Qiong Meng, Lawrence Mbuagbaw, Barbara Schmidt, Haresh Kirpalani, Lehana Thabane
Missing outcome data in clinical trials may jeopardize the validity of the trial results and inferences for clinical practice. Although sick and preterm newborns are treated as a captive patient population during their stay in the NICUs, their long-term outcomes are often ascertained after discharge. This greatly increases the risk of attrition. We surveyed recently published perinatal and neonatal randomized trials in 7 high-impact general medical and pediatric journals to review the handling of missing primary outcome data and any choice of imputation methods...
February 23, 2024: Pediatrics
https://read.qxmd.com/read/38370918/metal-concentrations-in-transitional-and-coastal-waters-measured-by-passive-diffusive-gradients-in-thin-films-and-spot-sampling-monitool-project-dataset
#4
JOURNAL ARTICLE
José Germán Rodríguez, Stephane Guesdon, Isabelle Amouroux, María Jesús Belzunce-Segarra, Philippe Bersuder, Thi Bolam, Pedro Brito, Miguel Caetano, Inês Carvalho, Margarida M Correia Dos Santos, Alessandro Desogus, Gary R Fones, Jean-Louis Gonzalez, Joana Larreta, Luc Lebrun, Barbara Marras, Brendan McHugh, Florence Menet-Nédélec, Iratxe Menchaca, Vanessa Millán Gabet, Carlos E Monteiro, Natalia Montero, Martin Nolan, Fiona Regan, Marta Rodrigo, Nuno Rosa, Marco Schintu, Anne Schmitt, Debora Todde, Lee Warford, Blánaid White, Hao Zhang
The MONITOOL project (2017-2023) was carried out to describe the relationships between total dissolved and labile metal concentrations measured in spot water samples and in concurrently deployed Diffusive Gradients in Thin-films (DGTs) passive samplers, respectively. The ultimate aim was to adapt existing marine metal Environmental Quality Standards (EQS marine water ) for DGTs, enabling their use in the context of the European Directives (the Water Framework Directive (WFD) and the Marine Strategy Framework Directive (MSFD))...
April 2024: Data in Brief
https://read.qxmd.com/read/38363970/reducing-menopausal-symptoms-with-mindfulness-based-meditation
#5
JOURNAL ARTICLE
Barbara Winges Conflitti, Sarah J Hoffman, Michelle Mathiason
Midlife women often experience menopausal symptoms despite being treated according to clinical guidelines. The consequences of not addressing menopausal symptoms holistically are that 55% of women see primary care providers frequently with menopausal symptom complaints. The problem was women's lack of coping strategies to deal with their symptoms effectively. The interventions aimed to (1) develop a protocol to provide point-of-care mindfulness-based meditation intervention as a standard of care, (2) evaluate improvements in coping self-efficacy skills, and (3) demonstrate the intervention's impact on menopausal symptoms...
March 2024: Holistic Nursing Practice
https://read.qxmd.com/read/38355619/lived-experiences-of-genetic-diagnosis-for-rare-disease-patients-a-qualitative-interview-study
#6
JOURNAL ARTICLE
Antonia Modelhart, Dominique Sturz, Lydia Kremslehner, Barbara Prainsack
BACKGROUND: Genetic diagnosis is often understood as a single event within the care pathway of rare disease patients. Legal, policy and ethical scholarship focusing on rare diseases and genetic information discusses questions of how to best deal with the process of genetic diagnosis and the communication of genetic information within a given health system. We co-created a research design with rare disease patients and their families in Austria to explore in-depth the experiences of genetic diagnosis for people affected by rare diseases...
February 14, 2024: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/38305877/avian-migration-clocks-in-a-changing-world
#7
REVIEW
Barbara Helm, Miriam Liedvogel
Avian long-distance migration requires refined programming to orchestrate the birds' movements on annual temporal and continental spatial scales. Programming is particularly important as long-distance movements typically anticipate future environmental conditions. Hence, migration has long been of particular interest in chronobiology. Captivity studies using a proxy, the shift to nocturnality during migration seasons (i.e., migratory restlessness), have revealed circannual and circadian regulation, as well as an innate sense of direction...
February 2, 2024: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://read.qxmd.com/read/38298587/colloidal-adsorption-in-planar-polymeric-brushes
#8
JOURNAL ARTICLE
Clemens Franz Vorsmann, Sara Del Galdo, Barbara Capone, Emanuele Locatelli
The design of nano-functionalised membranes or channels, able to effectively adsorb pollutants in aqueous solutions, is a topic that is gaining a great deal of attention in the materials science community. With this work we explore, through a combination of scaling theories and molecular dynamics simulations, the adsorption of spherical non-deformable colloidal nanoparticles within planar polymeric brushes. Our strategy is twofold: first, we generalise the Alexander-de Gennes theory for planar homopolymeric brushes to the case of diblock copolymer brushes, then we map the adsorbing homopolymeric brushes onto a diblock copolymer system, where the adsorbed colloids and all interacting monomers are considered monomers in bad solvent and we apply the generalised scaling theory to this effective diblock copolymer...
January 30, 2024: Nanoscale advances
https://read.qxmd.com/read/38242033/barriers-and-facilitators-to-viral-load-suppression-among-people-living-with-hiv-following-intensive-adherence-counseling-in-kampala-uganda-a-qualitative-study
#9
JOURNAL ARTICLE
Jonathan Izudi, Adithya Cattamanchi, Barbara Castelnuovo, Rachel King
We explored the barriers and facilitators to viral load (VL) suppression after three or more intensive adherence counseling (IAC) sessions among adolescents and adults living with human immunodeficiency virus (HIV) on a first-line anti-retroviral therapy (ART) with initially unsuppressed VL in Kampala, Uganda. Using a qualitative study, data were collected through in-depth interviews with people living with HIV (PLHIV) with unsuppressed and suppressed VL and caregivers of younger adolescents living with HIV after three or more IAC sessions...
January 14, 2024: Social Science & Medicine
https://read.qxmd.com/read/38154188/microbial-adaptations-and-biogeochemical-cycling-of-uranium-in-polymetallic-tailings
#10
JOURNAL ARTICLE
Santonu K Sanyal, Barbara Etschmann, Stephen B Hore, Jeremiah Shuster, Joël Brugger
Microorganisms inhabiting uranium (U)-rich environments have specific physiological and biochemical coping mechanisms to deal with U toxicity, and thereby play a crucial role in the U biogeochemical cycling as well as associated heavy metals. We investigated the diversity and functional capabilities of indigenous bacterial communities inhabiting historic U- and Rare-Earth-Elements-rich polymetallic tailings from the Mount Painter Inlier, Northern Flinders Ranges, South Australia. Bacterial diversity profiling identified Actinobacteria as the predominant phylum in all samples...
December 22, 2023: Journal of Hazardous Materials
https://read.qxmd.com/read/38064319/child-sexual-abuse-comparison-of-male-and-female-victims
#11
JOURNAL ARTICLE
Francesco Lupariello, Barbara Lauria, Federica Mirri, Sonia Aguzzi, Emanuele Castagno, Claudia Bondone, Giancarlo Di Vella
In the scientific literature, few authors deal with child sexual abuse (CSA) in boys. In addition, these authors debate this phenomenon in most available articles without statistically evaluating the occurrence of different or similar distributions of variables under sex. In light of the above, the authors compared multiple variables between female and male samples. The aim was to explore the characteristics of boys' CSA, identifying the main differences existing compared with the same phenomenon occurring in girls...
March 1, 2024: American Journal of Forensic Medicine and Pathology
https://read.qxmd.com/read/38033656/coping-strategies-for-handling-stress-and-providing-mental-health-in-elite-athletes-a-systematic-review
#12
REVIEW
Barbara Nuetzel
BACKGROUND: The combination of stressors unique to the athletic context plus the sensitive developmental phase that elite athletes go through during their peak performance may increase the athletes' vulnerability to mental health decrements. To emphasize the necessity to raise elite athletes' awareness of health risks, it seems to be essential to teach them coping skills to handle stress and to make affected athletes aware of how to recognize, evaluate, and articulate potential risks to their health...
2023: Frontiers in sports and active living
https://read.qxmd.com/read/38026661/dromedary-camel-s-welfare-literature-from-1980-to-2023-with-a-text-mining-and-topic-analysis-approach
#13
REVIEW
Naod T Masebo, Martina Zappaterra, Martina Felici, Beatrice Benedetti, Barbara Padalino
Dromedary camels are the preferable livestock species in the arid and semi-arid regions of the world. Most of the world's camel populations are managed under a subsistence/extensive system maintained by migratory pastoralists but intensification is getting more frequent. Even though recently the welfare of camels has been receiving more attention, in many countries there are no regulations to protect their health and welfare. The objectives of this article were to explore the main research topics related to camel welfare, their distribution over time and to highlight research gaps...
2023: Frontiers in Veterinary Science
https://read.qxmd.com/read/38016387/beyond-the-single-outcome-approach-a-comparison-of-outcome-wide-analysis-methods-for-exposome-research
#14
JOURNAL ARTICLE
Augusto Anguita-Ruiz, Ines Amine, Nikos Stratakis, Lea Maitre, Jordi Julvez, Jose Urquiza, Chongliang Luo, Mark Nieuwenhuijsen, Cathrine Thomsen, Regina Grazuleviciene, Barbara Heude, Rosemary McEachan, Marina Vafeiadi, Leda Chatzi, John Wright, Tiffany C Yang, Rémy Slama, Valérie Siroux, Martine Vrijheid, Xavier Basagaña
Outcome-wide analysis can offer several benefits, including increased power to detect weak signals and the ability to identify exposures with multiple effects on health, which may be good targets for preventive measures. Recently, advanced statistical multivariate techniques for outcome-wide analysis have been developed, but they have been rarely applied to exposome analysis. In this work, we provide an overview of a selection of methods that are well-suited for outcome-wide exposome analysis and are implemented in the R statistical software...
November 22, 2023: Environment International
https://read.qxmd.com/read/38007978/warpdrive-improving-spatial-normalization-using-manual-refinements
#15
JOURNAL ARTICLE
Simón Oxenford, Ana Sofía Ríos, Barbara Hollunder, Clemens Neudorfer, Alexandre Boutet, Gavin J B Elias, Jurgen Germann, Aaron Loh, Wissam Deeb, Bryan Salvato, Leonardo Almeida, Kelly D Foote, Robert Amaral, Paul B Rosenberg, David F Tang-Wai, David A Wolk, Anna D Burke, Marwan N Sabbagh, Stephen Salloway, M Mallar Chakravarty, Gwenn S Smith, Constantine G Lyketsos, Michael S Okun, William S Anderson, Zoltan Mari, Francisco A Ponce, Andres Lozano, Wolf-Julian Neumann, Bassam Al-Fatly, Andreas Horn
Spatial normalization-the process of mapping subject brain images to an average template brain-has evolved over the last 20+ years into a reliable method that facilitates the comparison of brain imaging results across patients, centers & modalities. While overall successful, sometimes, this automatic process yields suboptimal results, especially when dealing with brains with extensive neurodegeneration and atrophy patterns, or when high accuracy in specific regions is needed. Here we introduce WarpDrive, a novel tool for manual refinements of image alignment after automated registration...
January 2024: Medical Image Analysis
https://read.qxmd.com/read/37950793/barriers-to-the-spiritual-care-of-parents-taking-care-of-their-child-with-a-life-limiting-condition-at-home
#16
JOURNAL ARTICLE
Marije A Brouwer, Barbara C Bas-Douw, Carlo J W Leget, Marijanne Engel, Saskia C C M Teunissen, Marijke C Kars
UNLABELLED: The changes that parents face when caring for a child with a life-limiting condition at home can affect them on a spiritual level. Yet, indications remain that parents do not feel supported when dealing with spiritual issues related to caring for a severely ill child. This paper explores, from the perspectives of bereaved parents, chaplains, grief counselors, and primary health care providers, the barriers to supporting the spiritual needs of parents. We conducted a qualitative focus group study from a constructivist point with chaplains/grief counselors, primary care professionals, and bereaved parents...
November 11, 2023: European Journal of Pediatrics
https://read.qxmd.com/read/37936132/the-district-operation-centres-in-one-of-the-largest-local-health-authorities-in-italy-to-manage-covid-19-surveillance-and-homecare-first-implementation-and-results-of-a-survey-addressed-to-general-practitioners
#17
JOURNAL ARTICLE
Emanuela Maria Frisicale, Andrea Barbara, Alessio Perilli, Elettra Carini, Adriano Grossi, Leonardo Simonetti, Giulia Tammam, Svetlana Axelrod, Angelo Tanese, Mauro Goletti, Paolo Parente
BACKGROUND: COVID-19 pandemic represented a shock for healthcare systems. Italy was one of the first country to deal with a huge number of patients to be diagnosed, isolated, and treated with scarce evidence-based guidelines and resources. Several organizational and structural changes were needed to face the pandemic at local level. The article aims at studying the perceived impact of the newly implemented District Operation Centres (DOCs) of Local Health Authority (LHA) Roma 1 in managing active surveillance and home care of COVID-19 patients and their close contacts in cooperation with general practitioners (GPs)...
November 7, 2023: BMC Health Services Research
https://read.qxmd.com/read/37926189/simultaneous-sinus-elevation-and-immediate-implant-placement-without-biomaterial-a-technical-note
#18
JOURNAL ARTICLE
Estelle Guillou, Barbara Lerhe, Thomas Gemmi, Nouha Khenissa, Sarah Latrèche, Guillaume Loridon
Sinus floor elevation is widely considered as one of the most reliable and predictable procedures for augmenting posterior maxillary bone volume before implant placement. The lateral window technique is often described as the gold standard, especially when dealing with limited residual bone height. Traditionally, severe vertical defects in the posterior maxilla required a two-stage approach: first elevating the sinus membrane with biomaterial, followed by a second surgery for implant placement. This article introduces an innovative approach to the lateral sinus lift procedure, enabling simultaneous implant placement in sites with less than 5mm of remaining bone height...
November 3, 2023: Journal of Stomatology, Oral and Maxillofacial Surgery
https://read.qxmd.com/read/37896826/a-5-lipoxygenase-inhibitor-zileuton-modulates-host-immune-responses-and-improves-lung-function-in-a-model-of-severe-acute-respiratory-syndrome-sars-induced-by-betacoronavirus
#19
JOURNAL ARTICLE
Rafaela das Dores Pereira, Rayane Aparecida Nonato Rabelo, Natália Fernanda de Melo Oliveira, Samuel Luiz Teixeira Porto, Ana Claudia Dos Santos Pereira Andrade, Celso M Queiroz-Junior, César Luís Nascimento Barbosa, Luiz Pedro de Souza-Costa, Felipe Rocha da Silva Santos, Fernando Bento Rodrigues Oliveira, Bárbara Luísa Vieira da Silva, Hanna L Umezu, Raquel Ferreira, Glauber S F da Silva, Jader Santos Cruz, Mauro Martins Teixeira, Vivian Vasconcelos Costa, Fabiana Simão Machado
Exacerbated inflammatory responses are a hallmark of severe coronavirus disease 2019 (COVID-19). Zileuton (Zi) is a selective inhibitor of 5-lipoxygenase, an enzyme involved in the production of several inflammatory/pro-resolving lipid mediators. Herein, we investigated the effect of Zi treatment in a severe acute respiratory syndrome (SARS) model. Mouse hepatitis virus (MHV)3-infected mice treated with Zi significantly improved the clinical score, weight loss, cardiopulmonary function, and survival rates compared with infected untreated animals...
October 4, 2023: Viruses
https://read.qxmd.com/read/37895601/valorisation-of-tuff-and-brick-wastes-by-alkali-activation-for-historical-building-remediation
#20
JOURNAL ARTICLE
Ilaria Capasso, Gigliola D'Angelo, Marina Fumo, Mercedes Del Rio Merino, Domenico Caputo, Barbara Liguori
Nowadays, the preservation and restoration of a historical building needs to be faced in accordance with a novel sensibility regarding the environment in order to preserve the building for future generations. In this context, the scientific community is focusing on novel and sustainable materials and techniques that allow for durability and mechanical performance as well as compatibility with the existing heritage. Alkali-activated materials represent a great challenge to the production of new materials, starting from the existing ones, with the goal of reducing consumption, emission of greenhouse gases and environmental impact...
October 10, 2023: Materials
keyword
keyword
103258
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.