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Barbara Deal

Molly J Dingel, Jenny Ostergren, Kathleen Heaney, Barbara A Koenig, Jennifer McCormick
The gene has infiltrated the way citizens perceive themselves and their health. However, there is scant research that explores the ways genetic conceptions infiltrate individuals' understanding of their own health as it relates to a behavioral trait, like addiction. Do people seeking treatment for addiction ground their self-perception in biology in a way that shapes their experiences? We interviewed 63 participants in addiction treatment programs, asking how they make meaning of a genetic understanding of addiction in the context of their recovery, and in dealing with the stigma of addiction...
December 2017: BioSocieties
Barbara J Howard, Raymond Sturner
Purpose of review: To describe benefits and problems with screening and addressing developmental and behavioral problems in primary care and using an online clinical process support system as a solution. Recent findings: Screening has been found to have various implementation barriers including time costs, accuracy, workflow and knowledge of tools. In addition, training of clinicians in dealing with identified issues is lacking. Patients disclose more to and prefer computerized screening...
December 2017: Current Developmental Disorders Reports
Jane Kaye, Sharon F Terry, Eric Juengst, Sarah Coy, Jennifer R Harris, Don Chalmers, Edward S Dove, Isabelle Budin-Ljøsne, Clement Adebamowo, Emilomo Ogbe, Louise Bezuidenhout, Michael Morrison, Joel T Minion, Madeleine J Murtagh, Jusaku Minari, Harriet Teare, Rosario Isasi, Kazuto Kato, Emmanuelle Rial-Sebbag, Patricia Marshall, Barbara Koenig, Anne Cambon-Thomsen
BACKGROUND: Governments, funding bodies, institutions, and publishers have developed a number of strategies to encourage researchers to facilitate access to datasets. The rationale behind this approach is that this will bring a number of benefits and enable advances in healthcare and medicine by allowing the maximum returns from the investment in research, as well as reducing waste and promoting transparency. As this approach gains momentum, these data-sharing practices have implications for many kinds of research as they become standard practice across the world...
March 7, 2018: Human Genomics
Ewelina Namiecinska, Marta Sobiesiak, Magdalena Malecka, Piotr Guga, Barbara Rozalska, Elzbieta Budzisz
Antibiotic resistance acquired by various bacterial fungal and viral pathogens poses therapeutic problems of increasing severity. Among the infections that are very difficult to treat, biofilm-associated cases are one of the most hazardous. Complex structure of a biofilm and unique physiology of the biofilm cells contribute to their extremely high resistance to environmental conditions, antimicrobial agents and the mechanisms of host immune response. Therefore, the biofilm formation, especially by multidrug-resistant pathogens, is a serious medical problem, playing a pivotal role in the development of chronic and recurrent infections...
February 28, 2018: Current Medicinal Chemistry
Jennifer A Deal, A Richey Sharrett, Andreea M Rawlings, Rebecca F Gottesman, Karen Bandeen-Roche, Marilyn Albert, David Knopman, Elizabeth Selvin, Bruce A Wasserman, Barbara Klein, Ronald Klein
OBJECTIVE: To test the hypothesis that retinal vascular signs are associated with greater cognitive decline over 20 years in 12,317 men and women 50 to 73 years of age at baseline. METHODS: A composite cognitive score was created with 3 neuropsychological tests measured at 3 time points (1990-1992 to 2011-2013). Retinal signs were measured with fundus photography (1993-1995). Differences in cognitive change by retinal signs status were estimated with linear mixed models...
February 28, 2018: Neurology
Barbara Bukowska, Boleslaw T Karwowski
The clustered DNA lesions are a characteristic feature of ionizing radiation and are defined as two or more damage sites formed within 20 bps after the passage of a single radiation track. The clustered DNA lesions are divided into two major groups: double-stranded breaks (DSBs) and non-DSB clusters also known as Oxidatively-induced Clustered DNA Lesions (OCDLs), which could involve either two opposing strands or the same strand. As irradiation is gaining greater interest in cancer treatment as well as in imaging techniques, the detailed knowledge of its genotoxicity and the mechanisms of repair of radiation-induced DNA damage remain issues to explore...
February 25, 2018: Current Medicinal Chemistry
Adam Michał Czerwiński, Barbara Więckowska
BACKGROUND AND PURPOSE: External beam radiotherapy (EBRT) is one of three key treatment modalities of cancer patients. Its utilisation and outcomes depend on a plethora of variables, one of which is the distance a patient must travel to undergo the treatment. The relation between distance and utilisation is clearly visible in Poland. At the same time no strategic investment plan is observed. This work proposes a method of resolving these two issues. MATERIALS AND METHODS: We propose a mixed-integer linear programming model that aims to optimise the distribution of linear accelerators among selected locations in such a way that a patient's journey to the nearest EBRT is as short as possible...
February 21, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Andrea Weidt, Lorenz Gygax, Rupert Palme, Chadi Touma, Barbara König
In group living animals, reproductive competition plays an important role in shaping social relationships and associations among female group members. In this study, we investigated the impact of male presence on the development of female-female competition and female sociality in groups of female wild house mice, using physiological and behavioral parameters. We predicted that, by eliciting intra-sexual competition, males influence social relationships among female group members and thus affect female associations to potential cooperation partners...
February 20, 2018: Physiology & Behavior
Deborah A Marshall, Ken Deal, Barbara Conner-Spady, Eric Bohm, Gillian Hawker, Lynda Loucks, Karen V MacDonald, Tom Noseworthy
OBJECTIVE: Patients face significant waiting times for hip and knee total joint replacement (TJR) in publicly funded healthcare systems. We aimed to assess how surgeon selection and reputation affect patients' willingness to wait for TJR. DESIGN: We assessed patient preferences using a discrete choice experiment questionnaire with 12 choice scenarios administered to patients referred for TJR. Based on qualitative research, pre- and pilot-testing, we characterized each scenario by five attributes: surgeon reputation, surgeon selection, waiting time to surgeon visit (initial consultation), waiting time to surgery, and travel time to hospital...
February 6, 2018: Osteoarthritis and Cartilage
Barbara K Redman
A recent National Academy report on research integrity noted that policies are not evidence-based, with no formal entity responsible to attend to this deficit. Here we describe four areas of research misconduct (RM) regulations governing Public Health Service funded research that are empirically and/or ethically questionable. Policies for human subject protection, RM and conflict of interest are not harmonized, making it extremely difficult to deal with complex cases which often contain allegations in all of these areas...
February 5, 2018: Science and Engineering Ethics
Tolu O Oyesanya, Barbara J Bowers, Heather R Royer, Lyn S Turkstra
BACKGROUND: Patients with moderate-to-severe traumatic brain injury (TBI) typically have significant immediate and chronic cognitive impairments. These cognitive impairments can negatively affect their inpatient stay after an acute TBI and affect their healthcare later in life when seeking care for other acute health conditions during the chronic phase of TBI. Nurses must be knowledgeable about modifying care to accommodate cognitive impairments of these patients throughout the continuum of care...
February 5, 2018: Journal of Clinical Nursing
Alun C Jackson, Rosemary O Higgins, Erica Frydenberg, Rachel P-T Liang, Barbara M Murphy
PURPOSE: Studies of familial coping with a child's chronic condition have highlighted psychological distress; family functioning; and quality of life; as issues that demand coping strategies. There are conflicting findings on impact and coping and a paucity of information about the specific coping challenges for parents of a child with heart disease, with few qualitative studies in this area. The purpose of the study was to explore the way parents coped with their child's heart condition as it impacted on different domains of family functioning...
January 31, 2018: Journal of Pediatric Nursing
Francesco Baino, Elisa Fiume, Marta Miola, Federica Leone, Barbara Onida, Francesco Laviano, Roberto Gerbaldo, Enrica Verné
This work deals with the synthesis and characterization of novel Fe-containing sol-gel materials obtained by modifying the composition of a binary SiO₂-CaO parent glass with the addition of Fe₂O₃. The effect of different processing conditions (calcination in air vs. argon flowing) on the formation of magnetic crystalline phases was investigated. The produced materials were analyzed from thermal (hot-stage microscopy, differential thermal analysis, and differential thermal calorimetry) and microstructural (X-ray diffraction) viewpoints to assess both the behavior upon heating and the development of crystalline phases...
January 22, 2018: Materials
Miriam Luhnen, Barbara Prediger, Edmund A M Neugebauer, Tim Mathes
BACKGROUND: The number of systematic reviews of economic evaluations is steadily increasing. This is probably related to the continuing pressure on health budgets worldwide which makes an efficient resource allocation increasingly crucial. In particular in recent years, the introduction of several high-cost interventions presents enormous challenges regarding universal accessibility and sustainability of health care systems. An increasing number of health authorities, inter alia, feel the need for analyzing economic evidence...
December 2, 2017: Systematic Reviews
John M Costello, Elizabeth Preze, Nguyenvu Nguyen, Mary E McBride, James W Collins, Osama M Eltayeb, Michael C Mongé, Barbara J Deal, Michelle M Stephenson, Carl L Backer
BACKGROUND: We describe the implementation of and outcomes associated with an acuity adaptable care model for pediatric patients undergoing cardiac surgery. METHODS: Consecutive patients undergoing an index cardiac operation between July 2007 and June 2015 were included. From July 2007 through June 2010, a conventional model existed in which patients moved among units and care teams based on age, severity of illness, and operative status (conventional group). A transitional period existed between July 2010 and June 8, 2012 (transitional group)...
November 2017: World Journal for Pediatric & Congenital Heart Surgery
Sana M Al-Khatib, William G Stevenson, Michael J Ackerman, Anne M Gillis, William J Bryant, Mark A Hlatky, David J Callans, Christopher B Granger, Anne B Curtis, Stephen C Hammill, Barbara J Deal, José A Joglar, Timm Dickfeld, G Neal Kay, Michael E Field, Daniel D Matlock, Gregg C Fonarow, Robert J Myerburg, Richard L Page
No abstract text is available yet for this article.
October 30, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Sana M Al-Khatib, William G Stevenson, Michael J Ackerman, William J Bryant, David J Callans, Anne B Curtis, Barbara J Deal, Timm Dickfeld, Michael E Field, Gregg C Fonarow, Anne M Gillis, Mark A Hlatky, Christopher B Granger, Stephen C Hammill, José A Joglar, G Neal Kay, Daniel D Matlock, Robert J Myerburg, Richard L Page
No abstract text is available yet for this article.
October 26, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Sana M Al-Khatib, William G Stevenson, Michael J Ackerman, William J Bryant, David J Callans, Anne B Curtis, Barbara J Deal, Timm Dickfeld, Michael E Field, Gregg C Fonarow, Anne M Gillis, Mark A Hlatky, Christopher B Granger, Stephen C Hammill, José A Joglar, G Neal Kay, Daniel D Matlock, Robert J Myerburg, Richard L Page
No abstract text is available yet for this article.
October 25, 2017: Journal of the American College of Cardiology
Sana M Al-Khatib, William G Stevenson, Michael J Ackerman, William J Bryant, David J Callans, Anne B Curtis, Barbara J Deal, Timm Dickfeld, Michael E Field, Gregg C Fonarow, Anne M Gillis, Mark A Hlatky, Christopher B Granger, Stephen C Hammill, José A Joglar, G Neal Kay, Daniel D Matlock, Robert J Myerburg, Richard L Page
No abstract text is available yet for this article.
October 24, 2017: Journal of the American College of Cardiology
Barbara Head, Lesley Harris, Karen Kayser, Amy Martin, Lisa Smith
PURPOSE: The goal of this research was to understand how cancer survivors cope with the financial consequences of their disease. METHODS: Twenty-six cancer survivors who self-identified as having experienced financial hardship related to their disease were interviewed. Transcripts of these interviews were analyzed using constructivist grounded theory approach. An analysis of codes related to coping strategies was conducted, and findings were stratified based on established coping theories (Lazarus and Folkman and Moos and Holahan) previously applied to coping with serious/chronic illnesses...
October 11, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
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