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Honokiol and cancer

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https://www.readbyqxmd.com/read/29499462/identification-characterization-and-hplc-quantification-of-formulation-related-impurities-of-honokiol-an-antitumor-natural-drug-candidate-in-clinical-trials
#1
Wenshuang Wu, Ming-Hai Tang, Huan Tang, Kai Chen, Jie Fu, Lun Wang, Lin-Lin Xue, Aihua Peng, Haoyu Ye, Li-Juan Chen
Natural products and their derivatives have historically been invaluable as a source of therapeutic agents. Honokiol, as a well-known natural product in Chinese herbal medicine Houpu, is finally being studied in a Phase I clinical trial (CTR20170822) in patients with Advanced Non-Small Cell Lung Cancer (NSCLS) in China this year. During the honokiol liposome formulation process, five major impurities were present in the range of 0.05-0.1% based on the HPLC analysis. These five major impurities were obtained from the forced degradation product of honokiol through countercurrent chromatography and prep-HPLC...
February 21, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29397747/hyaluronic-acid-modified-micelles-encapsulating-gem-c12-and-hnk-for-glioblastoma-multiforme-chemotherapy
#2
Xing Liu, Wenhao Li, Tijia Chen, Qin Yang, Ting Huang, Yao Fu, Tao Gong, Zhirong Zhang
Glioblastoma multiforme (GBM), a prevalent brain cancer with high mortality, is resistant to the conventional single-agent chemotherapy. In this study, we employed a combination chemotherapy strategy to inhibit GBM growth and addressed its possible beneficial effects. The synergistic effect of lauroyl-gemcitabine (Gem-C12) and honokiol (HNK) was firstly tested and optimized using U87 cells in vitro. Then, the hyaluronic acid-grafted micelles (HA-M) encapsulating optimal mole ratio (1:1) of Gem-C12 and HNK were prepared, and characterized...
February 4, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29393336/honokiol-suppresses-proliferation-and-induces-apoptosis-via-regulation-of-the-mir%C3%A2-21-pten-pi3k-akt-signaling-pathway-in-human-osteosarcoma-cells
#3
Jiexiang Yang, Yonggen Zou, Dianmin Jiang
Honokiol (HNK) is a small biphenolic compound, which exerts antineoplastic effects in various types of cancer. However, the mechanism underlying the antitumor effects of HNK in osteosarcoma (OS) cells is not yet fully understood. Emerging evidence has indicated that microRNAs (miRNAs/miRs) serve key roles in numerous pathological processes, including cancer. It has previously been reported that Chinese medicinal herbs harbor anticancer properties via modulating miRNA expression. Therefore, the present study aimed to determine whether HNK could suppress OS cell growth by regulating miRNA expression...
January 29, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29367668/honokiol-is-a-foxm1-antagonist
#4
Marianna Halasi, Ben Hitchinson, Binal N Shah, Renáta Váraljai, Irum Khan, Elizaveta V Benevolenskaya, Vadim Gaponenko, Jack L Arbiser, Andrei L Gartel
Honokiol is a natural product and an emerging drug for a wide variety of malignancies, including hematopoietic malignancies, sarcomas, and common epithelial tumors. The broad range of activity of honokiol against numerous malignancies with diverse genetic backgrounds suggests that honokiol is inhibiting an activity that is common to multiple malignancies. Oncogenic transcription factor FOXM1 is one of the most overexpressed oncoproteins in human cancer. Here we found that honokiol inhibits FOXM1-mediated transcription and FOXM1 protein expression...
January 24, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29363886/honokiol-inhibits-in-vitro-and-in-vivo-growth-of-oral-squamous-cell-carcinoma-through-induction-of-apoptosis-cell-cycle-arrest-and-autophagy
#5
Kao-Jean Huang, Chin-Ho Kuo, Shu-Hsin Chen, Ching-Yen Lin, Ying-Ray Lee
Honokiol, an active natural product derived from Magnolia officinalis, exerted anticancer effects through a variety of mechanisms on multiple types of cancers. In this study, the molecular mechanisms of honokiol in suppressing the human oral squamous cell carcinoma (OSCC) cells were evaluated. Treatment of two OSCC cell lines with honokiol resulted in reducing the cell proliferation and arresting the cell cycle at G1 stage which was correlated with the down-regulation of Cdk2 and Cdk4 and the up-regulation of cell cycle suppressors, p21 and p27...
January 24, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29334266/hyaluronic-acid-modified-daunorubicin-plus-honokiol-cationic-liposomes-for-the-treatment-of-breast-cancer-along-with-the-elimination-vasculogenic-mimicry-channels
#6
Rui-Jun Ju, Lan Cheng, Xiao Qiu, Shuang Liu, Xiao-Li Song, Xiao-Ming Peng, Teng Wang, Cui-Qing Li, Xue-Tao Li
BACKGROUND: Breast cancer is an alarming global public health problem and a main cause of cancer-related death in women. Systemic chemotherapy is the most widely used treatment for breast cancer. However, current chemotherapy treatments are far from desirable due to poor targeting specificity, severe side effects and vasculogenic mimicry (VM). PURPOSE: Hyaluronic acid (HA)-modified daunorubicin plus honokiol (HNK) cationic liposomes were prepared and characterised for treatment of breast cancer by eliminating VM...
January 24, 2018: Journal of Drug Targeting
https://www.readbyqxmd.com/read/29332583/eating-green-shining-light-on-the-use-of-dietary-phytochemicals-as-a-modern-approach-in-the-prevention-and-treatment-of-head-and-neck-cancers
#7
Linda L Eastham, Candace M Howard, Premalatha Balachandran, David S Pasco, Pier Paolo Claudio
Enthusiasm for the use of dietary bioactive compounds as chemopreventive agents and adjuvants for current therapies has increased laboratory research conducted on several types of cancers including Head and Neck Squamous Cell Carcinoma (HNSCC). The green chemoprevention movement is a modern approach to highlight healthy lifestyle changes that aim to decrease the incidence of HNSCC. A healthy diet can be an effective way to prevent the development of oral cancers. Discovery of the naturally occurring plant based compounds called phytochemicals has facilitated the development of new treatment strategies for patients that are at risk for, or have developed HNSCC...
January 12, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29100031/research-on-major-antitumor-active-components-in-zi-cao-cheng-qi-decoction-based-on-hollow-fiber-cell-fishing-with-high-performance-liquid-chromatography
#8
Miaomiao Li, Shuang Hu, Xuan Chen, Runqin Wang, Xiaohong Bai
Hollow fiber cell fishing (HFCF) based on hepatoma HepG-2 cells, human renal tubular ACHN cells or human cervical carcinoma HeLa cells, coupled with high-performance liquid chromatography (HPLC), was developed and employed to research the major active components in Zi-Cao-Cheng-Qi decoction both in vitro and in vivo. The research showed that the active components, such as hesperidin, magnolol, honokiol, shikonin, emodin and β,β'-dimethylacrylshikonin were screened out by HFCF based on the cancer cells in vitro, furthermore they can be absorbed into blood and reach in the target organ, and some of the active components can be fished by the cells and maintain effective concentrations...
February 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29066893/application-of-multifunctional-targeting-epirubicin-liposomes-in-the-treatment-of-non-small-cell-lung-cancer
#9
Xiao-Li Song, Rui-Jun Ju, Yao Xiao, Xin Wang, Shuang Liu, Min Fu, Jing-Jing Liu, Li-Yan Gu, Xue-Tao Li, Lan Cheng
Chemotherapy for aggressive non-small-cell lung cancer (NSCLC) usually results in a poor prognosis due to tumor metastasis, vasculogenic mimicry (VM) channels, limited killing of tumor cells, and severe systemic toxicity. Herein, we developed a kind of multifunctional targeting epirubicin liposomes to enhance antitumor efficacy for NSCLC. In the liposomes, octreotide was modified on liposomal surface for obtaining a receptor-mediated targeting effect, and honokiol was incorporated into the lipid bilayer for inhibiting tumor metastasis and eliminating VM channels...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29054984/overcoming-resistance-to-cetuximab-with-honokiol-a-small-molecule-polyphenol
#10
Hannah E Pearson, Mari Iida, Rachel A Orbuch, Nellie K McDaniel, Kwangok P Nickel, Randall J Kimple, Jack L Arbiser, Deric L Wheeler
Overexpression and activation of the EGFR have been linked to poor prognosis in several human cancers. Cetuximab is a mAb against EGFR that is used for the treatment in head and neck squamous cell carcinoma (HNSCC) and metastatic colorectal cancer. Unfortunately, most tumors have intrinsic or will acquire resistance to cetuximab during the course of therapy. Honokiol is a natural compound found in the bark and leaves of the Chinese Magnolia tree and is established to have several anticancer properties without appreciable toxicity...
January 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28983589/honokiol-triggers-receptor%C3%A2-interacting-protein-kinase-3%C3%A2-mediated-cell-death-of-neuroblastoma-cells-by-upregulating-reactive-oxygen-species
#11
Jiao Zhang, Qiuliang Liu, Longyan Shi, Pan Qin, Qi Wang
Neuroblastoma is the most common form of childhood extracranial tumor and almost half of neuroblastoma cases occur in infants under two years old. Neuroblastoma accounts for ~6‑10% of childhood cancers and 15% of cancer‑associated childhood mortality. However, an effective treatment remains to be developed. Honokiol exhibits long‑lasting central muscle relaxation, anti‑inflammatory, antibacterial, antimicrobial, antiulcer, antioxidation, antiaging and antitumor effects. Honokiol has been previously demonstrated to kill neuroblastoma cells, however, the underlying mechanism of action remains unclear...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28943942/honokiol-inhibits-bladder-cancer-cell-invasion-through-repressing-src-3-expression-and-epithelial-mesenchymal-transition
#12
Lan Shen, Fang Zhang, Ruimin Huang, Jun Yan, Bing Shen
Urinary bladder cancer (UBC) is one of the most common urological cancer types. Muscle invasive bladder cancer possesses high propensity for metastasis with poor prognosis. Honokiol is a lignan isolated from Magnolia officinalis with high bioavailability and potent anticancer effects. The results of the present study demonstrated that honokiol significantly inhibited UBC cell migration and invasion in a dose-dependent manner compared with the vehicle-treated control group. In addition, honokiol treatment suppressed epithelial-mesenchymal transition by induction of E-cadherin and repression of N-cadherin...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28931882/honokiol-protects-against-doxorubicin-cardiotoxicity-via-improving-mitochondrial-function-in-mouse-hearts
#13
Lizhen Huang, Kailiang Zhang, Yingying Guo, Fengyuan Huang, Kevin Yang, Long Chen, Kai Huang, Fengxue Zhang, Qinqiang Long, Qinglin Yang
Honokiol is a key component of a medicinal herb, Magnolia bark. Honokiol possesses potential pharmacological benefits for many disease conditions, especially cancer. Recent studies demonstrate that Honokiol exerts beneficial effects on cardiac hypertrophy and doxorubicin (Dox)-cardiotoxicity via deacetylation of mitochondrial proteins. However, the effects and mechanisms of Honokiol on cardiac mitochondrial respiration remain unclear. In the present study, we investigate the effect of Honokiol on cardiac mitochondrial respiration in mice subjected to Dox treatment...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28842335/concurrently-suppressing-multidrug-resistance-and-metastasis-of-breast-cancer-by-co-delivery-of-paclitaxel-and-honokiol-with-ph-sensitive-polymeric-micelles
#14
Ziqi Wang, Xinru Li, Dishi Wang, Yang Zou, Xiaoyou Qu, Chuyu He, Yunqiang Deng, Yao Jin, Yuanhang Zhou, Yanxia Zhou, Yan Liu
To concurrently suppress multidrug resistance (MDR) and metastasis of breast cancer cells, paclitaxel (PTX) and honokiol (HNK) were coencapsulated into pH-sensitive polymeric micelles based on poly(2-ethyl-2-oxazoline)-poly(d,l-lactide) (PEOz-PLA). The physicochemical properties of dual drug-loaded PEOz-PLA micelles were characterized in size, drug loading and in vitro release. The efficiency of MDR reversal for the micelles was testified by synergetic enhancement of cytotoxicity and uptake by MCF-7/ADR cells...
August 28, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28731124/bmp7-mediates-the-anticancer-effect-of-honokiol-by-upregulating-p53-in-hct116-cells
#15
Rong-Xing Liu, Wen-Yan Ren, Yan Ma, Yun-Peng Liao, Han Wang, Jia-Hui Zhu, Hai-Tao Jiang, Ke Wu, Bai-Cheng He, Wen-Juan Sun
Colorectal cancer (CRC) is the second leading cause of cancer death. Hence, there is a great need to explore new efficacious drugs for the treatment of CRC. Honokiol (HNK), a natural product extracted from magnolia bark, processes various biological activities, including anticancer. In this study, we introduced cell viability assay, western blotting, real-time PCR and immunofluorescent staining to determine the anticancer effect of HNK, and the possible mechanism underlying this biological process. We found that HNK can inhibit the proliferation and induce apoptosis in HCT116 cells in a concentration- and time-dependent manner...
July 21, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28724911/honokiol-inhibits-c-met-ho-1-tumor-promoting-pathway-and-its-cross-talk-with-calcineurin-inhibitor-mediated-renal-cancer-growth
#16
Murugabaskar Balan, Samik Chakraborty, Evelyn Flynn, David Zurakowski, Soumitro Pal
Honokiol (HNK) is a small molecule with potent anti-inflammatory and anti-tumorigenic properties; yet the molecular targets of HNK are not well studied. Hyperactivation of the receptor tyrosine kinase c-Met and overexpression of the cytoprotective enzyme heme oxygenase-1 (HO-1) play a critical role in the growth and progression of renal cell carcinoma (RCC). Interestingly, the calcineurin inhibitor (CNI) cyclosporine A (CsA), an immunosuppressant used to prevent allograft rejection, can also increase the risk of RCC in transplant patients...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28689115/liposomal-honokiol-induced-lysosomal-degradation-of-hsp90-client-proteins-and-protective-autophagy-in-both-gefitinib-sensitive-and-gefitinib-resistant-nsclc-cells
#17
Jianhong Yang, Wenshuang Wu, Jiaolin Wen, Haoyu Ye, Hong Luo, Peng Bai, Minghai Tang, Fang Wang, Li Zheng, Shengyong Yang, Weimin Li, Aihua Peng, Li Yang, Li Wan, Lijuan Chen
Honokiol (HK), a natural chemical isolated from Mangnolia officinalis, has shown antitumorigenic activities when used to treat a variety of tumor cell lines. The mechanism of honokiol activity when used to treat gefitinib-sensitive and gefitinib-resistant non-small cell lung cancer (NSCLC) requires elucidation. Here, the presence of liposomal honokiol (LHK) induced apoptotic and antitumor activities in four xenograft models generated using NSCLC cell lines such as HCC827 (gefitinib-sensitive) and H1975 (gefitinib-resistant)...
October 2017: Biomaterials
https://www.readbyqxmd.com/read/28620301/chemopreventive-activity-of-honokiol-against-7-12-dimethylbenz-a-anthracene-induced-mammary-cancer-in-female-sprague-dawley-rats
#18
Zhenyu Wang, Xingyi Zhang
Breast cancer is a predominant cause of death in women across the globe. Chemoprevention by using natural, dietary or synthetic products has been appearing to be a fascinating approach to combat the growing burden of breast cancer. In the current study, we intended to explore the mechanisms of chemopreventive action of honokiol against 7, 12 - dimethylbenz[a]anthracene (DMBA)-induced mammary cancer in female Sprague Dawlely (SD) rats. We induced mammary cancer in SD rats by administering single dose of DMBA (80 mg/kg) through intra gastric route...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28581518/activation-of-tumor-suppressor-lkb1-by-honokiol-abrogates-cancer-stem-like-phenotype-in-breast-cancer-via-inhibition-of-oncogenic-stat3
#19
S Sengupta, A Nagalingam, N Muniraj, M Y Bonner, P Mistriotis, A Afthinos, P Kuppusamy, D Lanoue, S Cho, P Korangath, M Shriver, A Begum, V F Merino, C-Y Huang, J L Arbiser, W Matsui, B Győrffy, K Konstantopoulos, S Sukumar, P A Marignani, N K Saxena, D Sharma
Tumor suppressor and upstream master kinase Liver kinase B1 (LKB1) plays a significant role in suppressing cancer growth and metastatic progression. We show that low-LKB1 expression significantly correlates with poor survival outcome in breast cancer. In line with this observation, loss-of-LKB1 rendered breast cancer cells highly migratory and invasive, attaining cancer stem cell-like phenotype. Accordingly, LKB1-null breast cancer cells exhibited an increased ability to form mammospheres and elevated expression of pluripotency-factors (Oct4, Nanog and Sox2), properties also observed in spontaneous tumors in Lkb1-/- mice...
October 12, 2017: Oncogene
https://www.readbyqxmd.com/read/28490739/honokiol-inhibits-ultraviolet-radiation-induced-immunosuppression-through-inhibition-of-ultraviolet-induced-inflammation-and-dna-hypermethylation-in-mouse-skin
#20
Ram Prasad, Tripti Singh, Santosh K Katiyar
Ultraviolet (UV) radiation exposure induces immunosuppression, which contributes to the development of cutaneous malignancies. We investigated the effects of honokiol, a phytochemical found in plants of the genus Magnolia, on UVB-induced immunosuppression using contact hypersensitivity (CHS) as a model in C3H/HeN mice. Topical application of honokiol (0.5 and 1.0 mg/cm(2) skin area) had a significant preventive effect on UVB-induced suppression of the CHS response. The inflammatory mediators, COX-2 and PGE2, played a key role in this effect, as indicated by honokiol inhibition of cyclooxygenase-2 (COX-2) expression and PGE2 production in the UVB-exposed skin...
May 10, 2017: Scientific Reports
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