Sepideh Mirzaei, Mahshid Deldar Abad Paskeh, Farhad Adhami Moghadam, Maliheh Entezari, Zeinab Khazaei Koohpar, Elahe Sadat Hejazi, Shamin Rezaei, Amirabbas Kakavand, Maryam Aboutalebi, Mohammad Arad Zandieh, Romina Rajabi, Shokooh Salimimoghadam, Afshin Taheriazam, Mehrdad Hashemi, Saeed Samarghandian
The treatment of cancer patients has been prohibited by chemoresistance. Doxorubicin (DOX) is an anti-tumor compound disrupting proliferation and triggering cell cycle arrest via inhibiting activity of topoisomerase I and II. miRNAs are endogenous RNAs localized in cytoplasm to reduce gene level. Abnormal expression of miRNAs changes DOX cytotoxicity. Overexpression of tumor-promoting miRNAs induces DOX resistance, while tumor-suppressor miRNAs inhibit DOX resistance. The miRNA-mediated regulation of cell death and hallmarks of cancer can affect response to DOX chemotherapy in tumor cells...
December 2023: Journal of Cell Communication and Signaling