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Modified citrus pectin

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https://www.readbyqxmd.com/read/27842844/rheological-and-chemical-properties-of-pectin-enriched-fractions-from-different-sources-extracted-with-citric-acid
#1
Joanna Mierczyńska, Justyna Cybulska, Artur Zdunek
Yield, properties and functionality of pectins depend on the source material and method of extraction. The objective of this work was to compare pectinolytic enzyme activity in fresh pulp as well as the physicochemical and rheological properties of polysaccharides extracted with citric acid from six new potential sources: fruit materials - peach, blackcurrant, raspberry, strawberry, plum and a vegetable Source: carrot. The uronic acid content of polysaccharides extracted in citric acid depended on pectinolytic enzymes activity in fresh plant tissues and ranged between 16...
January 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27829066/galectin-3-blockade-reduces-renal-fibrosis-in-two-normotensive-experimental-models-of-renal-damage
#2
Ernesto Martinez-Martinez, Jaime Ibarrola, Laurent Calvier, Amaya Fernandez-Celis, Celine Leroy, Victoria Cachofeiro, Patrick Rossignol, Natalia Lopez-Andres
BACKGROUND: Galectin-3 (Gal-3), a β-galactoside-binding lectin, is increased in kidney injury and its pharmacological blockade reduces renal damage in acute kidney injury, hyperaldosteronism or hypertensive nephropathy. We herein investigated the effects of pharmacological Gal-3 inhibition by modified citrus pectin (MCP) in early renal damage associated with obesity and aortic stenosis (AS). RESULTS: Gal-3 was upregulated in kidneys from high fat diet (HFD) rats and in animals with partial occlusion of ascending aorta (AS)...
2016: PloS One
https://www.readbyqxmd.com/read/27815266/role-for-galectin-3-in-calcific-aortic-valve-stenosis
#3
J Rafael Sádaba, Ernesto Martínez-Martínez, Vanessa Arrieta, Virginia Álvarez, Amaya Fernández-Celis, Jaime Ibarrola, Amaia Melero, Patrick Rossignol, Victoria Cachofeiro, Natalia López-Andrés
BACKGROUND: Aortic stenosis (AS) is a chronic inflammatory disease, and calcification plays an important role in the progression of the disease. Galectin-3 (Gal-3) is a proinflammatory molecule involved in vascular osteogenesis in atherosclerosis. Therefore, we hypothesized that Gal-3 could mediate valve calcification in AS. METHODS AND RESULTS: Blood samples and aortic valves (AVs) from 77 patients undergoing AV replacement were analyzed. As controls, noncalcified human AVs were obtained at autopsy (n=11)...
November 4, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27129206/low-or-no-inhibitory-potency-of-the-canonical-galectin-carbohydrate-binding-site-by-pectins-and-galactomannans
#4
John Stegmayr, Adriana Lepur, Barbro Kahl-Knutson, Matilde Aguilar-Moncayo, Anatole A Klyosov, Robert A Field, Stina Oredsson, Ulf J Nilsson, Hakon Leffler
Some complex plant-derived polysaccharides, such as modified citrus pectins and galactomannans, have been shown to have promising anti-inflammatory and anti-cancer effects. Most reports propose or claim that these effects are due to interaction of the polysaccharides with galectins because the polysaccharides contain galactose-containing side chains that might bind this class of lectin. However, their direct binding to and/or inhibition of the evolutionarily conserved galactoside-binding site of galectins has not been demonstrated...
June 17, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27010252/modified-citrus-pectin-stops-progression-of-liver-fibrosis-by-inhibiting-galectin-3-and-inducing-apoptosis-of-stellate-cells
#5
Nashwa M Abu-Elsaad, Wagdi Fawzi Elkashef
Modified citrus pectin (MCP) is a pH modified form of the dietary soluble citrus peel fiber known as pectin. The current study aims at testing its effect on liver fibrosis progression. Rats were injected with CCl4 (1 mL/kg, 40% v/v, i.p., twice a week for 8 weeks). Concurrently, MCP (400 or 1200 mg/kg) was administered daily in drinking water from the first week in groups I and II (prophylactic model) and in the beginning of week 5 in groups III and IV (therapeutic model). Liver function biomarkers (ATL, AST, and ALP), fibrosis markers (laminin and hyaluronic acid), and antioxidant biomarkers (reduced glutathione (GSH) and superoxide dismutase (SOD)) were measured...
May 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/26872020/galectin-3-inhibition-is-associated-with-neuropathic-pain-attenuation-after-peripheral-nerve-injury
#6
Zhicong Ma, Qi Han, Xiaolei Wang, Zisheng Ai, Yongjun Zheng
Neuropathic pain remains a prevalent and persistent clinical problem because it is often poorly responsive to the currently used analgesics. It is very urgent to develop novel drugs to alleviate neuropathic pain. Galectin-3 (gal3) is a multifunctional protein belonging to the carbohydrate-ligand lectin family, which is expressed by different cells. Emerging studies showed that gal3 elicits a pro-inflammatory response by recruiting and activating lymphocytes, macrophages and microglia. In the study we investigated whether gal3 inhibition could suppress neuroinflammation and alleviate neuropathic pain following peripheral nerve injury...
2016: PloS One
https://www.readbyqxmd.com/read/26853916/galectin-3-inhibition-prevents-adipose-tissue-remodelling-in-obesity
#7
E Martínez-Martínez, L Calvier, P Rossignol, E Rousseau, A Fernández-Celis, R Jurado-López, M Laville, V Cachofeiro, N López-Andrés
Extracellular matrix remodelling of the adipose tissue has a pivotal role in the pathophysiology of obesity. Galectin-3 (Gal-3) is increased in obesity and mediates inflammation and fibrosis in the cardiovascular system. However, the effects of Gal-3 on adipose tissue remodelling associated with obesity remain unclear. Male Wistar rats were fed either a high-fat diet (33.5% fat) or a standard diet (3.5% fat) for 6 weeks. Half of the animals of each group were treated with the pharmacological inhibitor of Gal-3, modified citrus pectin (MCP; 100 mg kg(-1) per day) in the drinking water...
June 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/26781273/inhibition-of-galectin-3-pathway-prevents-isoproterenol-induced-left-ventricular-dysfunction-and-fibrosis-in-mice
#8
Giuseppe Vergaro, Mathilde Prud'homme, Loubina Fazal, Regine Merval, Claudio Passino, Michele Emdin, Jane-Lise Samuel, Alain Cohen Solal, Claude Delcayre
Galectin-3 (Gal-3) is involved in inflammation, fibrogenesis, and cardiac remodeling. Previous evidence shows that Gal-3 interacts with aldosterone in promoting macrophage infiltration and vascular fibrosis and that Gal-3 genetic and pharmacological inhibition prevents remodeling in a pressure-overload animal model of heart failure. We aimed to explore the contribution of Gal-3 and aldosterone in mechanisms leading to heart failure in a murine model. Male mice with cardiac-specific hyperaldosteronism underwent isoproterenol subcutaneous injections, to be then randomized to receive placebo, a Gal-3 inhibitor (modified citrus pectin [MCP]), an aldosterone antagonist (potassium canrenoate), or MCP+canrenoate for 14 days...
March 2016: Hypertension
https://www.readbyqxmd.com/read/26686103/identification-of-a-cytotoxic-molecule-in-heat-modified-citrus-pectin
#9
Lionel Leclere, Maude Fransolet, Pierre Cambier, Sandy El Bkassiny, Abdellatif Tikad, Marc Dieu, Stéphane P Vincent, Pierre Van Cutsem, Carine Michiels
Modified forms of citrus pectin possess anticancer properties. However, their mechanism of action and the structural features involved remain unclear. Here, we showed that citrus pectin modified by heat treatment displayed cytotoxic effects in cancer cells. A fractionation approach was used aiming to identify active molecules. Dialysis and ethanol precipitation followed by HPLC analysis evidenced that most of the activity was related to molecules with molecular weight corresponding to low degree of polymerization oligogalacturonic acid...
February 10, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/26572430/modified-sugar-beet-pectin-induces-apoptosis-of-colon-cancer-cells-via-an-interaction-with-the-neutral-sugar-side-chains
#10
Ellen G Maxwell, Ian J Colquhoun, Hoa K Chau, Arland T Hotchkiss, Keith W Waldron, Victor J Morris, Nigel J Belshaw
Pectins extracted from a variety of sources and modified with heat and/or pH have previously been shown to exhibit activity towards several cancer cell lines. However, the structural basis for the anti-cancer activity of modified pectin requires clarification. Sugar beet and citrus pectin extracts have been compared. Pectin extracted from sugar beet pulp only weakly affected the viability of colon cancer cells. Alkali treatment increased the anti-cancer effect of sugar beet pectin via an induction of apoptosis...
January 20, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/26351031/galectin-3-participates-in-cardiovascular-remodeling-associated-with-obesity
#11
COMPARATIVE STUDY
Ernesto Martínez-Martínez, Natalia López-Ándres, Raquel Jurado-López, Elodie Rousseau, Mará Visitación Bartolomé, Amaya Fernández-Celis, Patrick Rossignol, Fabian Islas, Alfonso Antequera, Santiago Prieto, María Luaces, Victoria Cachofeiro
Remodeling, diastolic dysfunction, and arterial stiffness are some of the alterations through which obesity affects the cardiovascular system. Fibrosis and inflammation are important mechanisms underlying cardiovascular remodeling, although the precise promoters involved in these processes are still unclear. Galectin-3 (Gal-3) induces inflammation and fibrosis in the cardiovascular system. We have investigated the potential role of Gal-3 in cardiac damage in morbidly obese patients, and we have evaluated the protective effect of the Gal-3 inhibition in the occurrence of cardiovascular fibrosis and inflammation in an experimental model of obesity...
November 2015: Hypertension
https://www.readbyqxmd.com/read/26254367/chemoprevention-of-azoxymethane-induced-colonic-carcinogenesis-in-balb-c-mice-using-a-modified-pectin-alginate-probiotic
#12
Frederick Odun-Ayo, John Mellem, Thajasvarie Naicker, Lalini Reddy
BACKGROUND: Increased intake of probiotic dietary fibre reduces colonic cancer risk. Modified citrus pectin (MCP) requires optimal bioactivity to inhibit galectin-3 (GAL-3) and vascular endothelial growth factor (VEGF). This study evaluated the preventative effect of modified pectin alginate (MCPA) probiotic microbeads on azoxymethane (AOM)-induced colonic carcinogenesis in Balb/c mice. MATERIALS AND METHODS: Optimization of AOM dose duration: 10-15 mg/kg was administered for 2-4 weeks...
September 2015: Anticancer Research
https://www.readbyqxmd.com/read/26238446/galectin-3-blockade-inhibits-cardiac-inflammation-and-fibrosis-in-experimental-hyperaldosteronism-and-hypertension
#13
Ernesto Martínez-Martínez, Laurent Calvier, Amaya Fernández-Celis, Elodie Rousseau, Raquel Jurado-López, Luciana V Rossoni, Frederic Jaisser, Faiez Zannad, Patrick Rossignol, Victoria Cachofeiro, Natalia López-Andrés
Hypertensive cardiac remodeling is accompanied by molecular inflammation and fibrosis, 2 mechanisms that finally affect cardiac function. At cardiac level, aldosterone promotes inflammation and fibrosis, although the precise mechanisms are still unclear. Galectin-3 (Gal-3), a β-galactoside-binding lectin, is associated with inflammation and fibrosis in the cardiovascular system. We herein investigated whether Gal-3 inhibition could block aldosterone-induced cardiac inflammation and fibrosis and its potential role in cardiac damage associated with hypertension...
October 2015: Hypertension
https://www.readbyqxmd.com/read/26139875/physicochemical-properties-of-modified-citrus-pectins-extracted-from-orange-pomace
#14
Simoni Spohr Venzon, Maria Helene Giovanetti Canteri, Daniel Granato, Bogdan Demczuk Junior, Giselle Maria Maciel, Ana Paula Stafussa, Charles Windson Isidoro Haminiuk
Modified pectin is a polysaccharide rich in galacturonic acid altered by pH adjustment and thermal treatment used especially as an anti-cancer agent. The aim of this work was to study the physical and chemical properties of modified pectins extracted from orange pomace with citric and nitric acids. The galacturonic acid content, degree of esterification, Fourier Transform Infrared Spectroscopy profile, molecular weight, intrinsic viscosity, rheological properties and antioxidant activity of the pectins were evaluated...
July 2015: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/25794149/heat-modified-citrus-pectin-induces-apoptosis-like-cell-death-and-autophagy-in-hepg2-and-a549-cancer-cells
#15
Lionel Leclere, Maude Fransolet, Francois Cote, Pierre Cambier, Thierry Arnould, Pierre Van Cutsem, Carine Michiels
Cancer is still one of the leading causes of death worldwide, and finding new treatments remains a major challenge. Previous studies showed that modified forms of pectin, a complex polysaccharide present in the primary plant cell wall, possess anticancer properties. Nevertheless, the mechanism of action of modified pectin and the pathways involved are unclear. Here, we show that citrus pectin modified by heat treatment induced cell death in HepG2 and A549 cells. The induced cell death differs from classical apoptosis because no DNA cleavage was observed...
2015: PloS One
https://www.readbyqxmd.com/read/25704690/ultrasound-assisted-heating-extraction-of-pectin-from-grapefruit-peel-optimization-and-comparison-with-the-conventional-method
#16
COMPARATIVE STUDY
Wenjun Wang, Xiaobin Ma, Yuting Xu, Yongqiang Cao, Zhumao Jiang, Tian Ding, Xingqian Ye, Donghong Liu
The extraction of pectin from grapefruit peel by ultrasound-assisted heating extraction (UAHE) was investigated using response surface methodology and compared with the conventional heating extraction (CHE). The optimized conditions were power intensity of 12.56 W/cm(2), extraction temperature of 66.71°C, and sonication time of 27.95 min. The experimental optimized yield was 27.34%, which was well matched with the predicted value (27.46%). Compared with CHE, UAHE provided higher yield increased by 16.34% at the temperature lowered by 13...
July 1, 2015: Food Chemistry
https://www.readbyqxmd.com/read/25689620/galectin-3-is-a-sensor-regulator-of-toll-like-receptor-pathways-in-synovial-fibroblasts
#17
Uri Arad, Noa Madar-Balakirski, Avital Angel-Korman, Sharon Amir, Sharon Tzadok, Ortal Segal, Aharon Menachem, Aviram Gold, Ori Elkayam, Dan Caspi
Galectin-3 is a β-galactoside-binding lectin that plays an important role in the modulation of immune responses. It has been shown to aggravate joint inflammation and destruction in experimental arthritis. We investigated the role of galectin-3 in TLR-induced cell activation in human synovial fibroblasts (SF) in order to better understand the mechanism(s) of the proinflammatory function of galectin-3 in arthritis. Galectin-3 expression in SF obtained from rheumatoid arthritis and osteoarthritis patients was inhibited by siRNA mediated gene-knockdown...
May 2015: Cytokine
https://www.readbyqxmd.com/read/25458291/cholesterol-and-fat-lowering-with-hydrophobic-polysaccharide-derivatives
#18
Jana Čopíková, Tomáš Taubner, Jan Tůma, Andriy Synytsya, Dagmar Dušková, Milan Marounek
Hydrophobic derivatives of highly methylated citrus pectin, chitosan and cellulose were prepared and tested as potential cholesterol lowering agents. Elemental analysis and spectroscopic methods confirmed high substitution degree for all of them. Substitution with long alkyl/acyl groups led to significant changes in physical and thermal properties of modified polysaccharides. Sorption of cholate and cholesterol by these polysaccharide-based sorbents was estimated in comparison with the synthetic drug cholestyramine...
February 13, 2015: Carbohydrate Polymers
https://www.readbyqxmd.com/read/25458174/the-impact-of-galectin-3-inhibition-on-aldosterone-induced-cardiac-and-renal-injuries
#19
Laurent Calvier, Ernesto Martinez-Martinez, Maria Miana, Victoria Cachofeiro, Elodie Rousseau, J Rafael Sádaba, Faiez Zannad, Patrick Rossignol, Natalia López-Andrés
OBJECTIVES: This study investigated whether galectin (Gal)-3 inhibition could block aldosterone-induced cardiac and renal fibrosis and improve cardiorenal dysfunction. BACKGROUND: Aldosterone is involved in cardiac and renal fibrosis that is associated with the development of cardiorenal injury. However, the mechanisms of these interactions remain unclear. Gal-3, a β-galactoside-binding lectin, is increased in heart failure and kidney injury. METHODS: Rats were treated with aldosterone-salt combined with spironolactone (a mineralocorticoid receptor antagonist) or modified citrus pectin (a Gal-3 inhibitor), for 3 weeks...
January 2015: JACC. Heart Failure
https://www.readbyqxmd.com/read/24952269/galectin-3-expressed-on-different-lung-compartments-promotes-organ-specific-metastasis-by-facilitating-arrest-extravasation-and-organ-colonization-via-high-affinity-ligands-on-melanoma-cells
#20
Manohar C Dange, Nithya Srinivasan, Shyam K More, Sanjay M Bane, Archana Upadhya, Arvind D Ingle, Rajiv P Gude, Rabindranath Mukhopadhyaya, Rajiv D Kalraiya
Interactions between molecules on the surface of tumor cells and those on the target organ endothelium play an important role in their arrest in an organ. Galectin-3 on the lung endothelium and high affinity ligands poly-N-acetyllactosamine (polyLacNAc) on N-oligosaccharides on melanoma cells facilitate such interactions. However, to extravasate and colonize an organ the cells must stabilize these interactions by spreading to retract endothelium, degrade exposed basement membrane (BM) and move into parenchyma and proliferate...
August 2014: Clinical & Experimental Metastasis
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