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Turmeric and cancer

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https://www.readbyqxmd.com/read/29623828/a-novel-fluorescence-labeled-curcumin-conjugate-synthesis-evaluation-and-imaging-on-human-cell-lines
#1
Sumbla Sheikh, Alexander Sturzu, Hubert Kalbacher, Thomas Nagele, Christopher Weidenmaier, Marius Horger, Christian Schwentner, Ulrike Ernemann, Stefan Heckl
Curcumin, as the main ingredient of the curcuma spice has increasingly become the target of scientific research. The turmeric root which the spice is obtained from has been widely used in traditional medicine and scientific studies found anti-inflammatory, anti-cancer, anti-angiogenic effects as well as antibacterial properties for curcumin. Recently, curcumin has gathered interest as potential therapeutic agent in the research on Alzheimer's disease. A consistent problem in the investigative and therapeutic applications of curcumin is its poor solubility in aqueous solutions...
April 5, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29621160/therapeutic-potential-and-recent-advances-of-curcumin-in-the-treatment-of-aging-associated-diseases
#2
REVIEW
Sathish Sundar Dhilip Kumar, Nicolette Nadene Houreld, Heidi Abrahamse
Curcumin, a low molecular weight, lipophilic, major yellow natural polyphenolic, and the most well-known plant-derived compound, is extracted from the rhizomes of the turmeric ( Curcuma longa ) plant. Curcumin has been demonstrated as an effective therapeutic agent in traditional medicine for the treatment and prevention of different diseases. It has also shown a wide range of biological and pharmacological effects in drug delivery, and has actively been used for the treatment of aging-associated diseases, including cardiovascular diseases, atherosclerosis, neurodegenerative diseases, cancer, rheumatoid arthritis, ocular diseases, osteoporosis, diabetes, hypertension, chronic kidney diseases, chronic inflammation and infection...
April 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29568962/dickkopf%C3%A2-3-upregulation-mediates-the-cardioprotective-effects-of-curcumin-on-chronic-heart-failure
#3
Quan Cao, Junxia Zhang, Ling Gao, Yijie Zhang, Mingyan Dai, Mingwei Bao
Curcumin, isolated from rhizome of turmeric, has been widely studied as a potential therapeutic drug for cancer. However, protective effects of curcumin on chronic heart failure (CHF) have not been fully studied. In the present study, the effects of curcumin on CHF and the underlying mechanisms were investigated. A total of 40 rabbits were randomized into 4 groups: Control rabbits fed with placebo (Con) or curcumin (Con‑cur), CHF rabbits fed with placebo (CHF) or curcumin (CHF‑cur). CHF was induced by volume and pressure overload...
March 20, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29549231/effect-of-cinnamon-and-turmeric-aqueous-extracts-on-serum-interleukin-17f-level-of-high-fructose-fed-rats
#4
Maryam Sohrabi, Mahdi Alahgholi-Hajibehzad, Zahra Gholami Mahmoodian, Sayed Ali Hosseini Siyar, Alireza Zamani
BACKGROUND: Studies have indicated that extraweight and obesity induce chronic inflammation, which can lead to other diseases such as cancers. OBJECTIVE: To evaluate the effects of two weight-lowering and anti-inflammatory agents including cinnamon, and turmeric, on serum levels of interleukin-17 (IL-17) as a pro-inflammatory cytokine. METHODS: In this study, 64 rats were designated in eight groups. The control group received normal diet. The other groups were fed with normal diet plus high cinnamon (3 mg/ml), high turmeric (3 mg/ml), high-fructose solution (30%), fructose solution with low (0...
March 2018: Iranian Journal of Immunology: IJI
https://www.readbyqxmd.com/read/29527430/green-synthesis-of-fluorescent-carbon-dots-from-spices-for-in-vitro-imaging-and-tumour-cell-growth-inhibition
#5
Nagamalai Vasimalai, Vânia Vilas-Boas, Juan Gallo, María de Fátima Cerqueira, Mario Menéndez-Miranda, José Manuel Costa-Fernández, Lorena Diéguez, Begoña Espiña, María Teresa Fernández-Argüelles
Carbon dots have demonstrated great potential as luminescent nanoparticles in bioapplications. Although such nanoparticles appear to exhibit low toxicity compared to other metal luminescent nanomaterials, today we know that the toxicity of carbon dots (C-dots) strongly depends on the protocol of fabrication. In this work, aqueous fluorescent C-dots have been synthesized from cinnamon, red chilli, turmeric and black pepper, by a one-pot green hydrothermal method. The synthesized C-dots were firstly characterized by means of UV-vis, fluorescence, Fourier transform infrared and Raman spectroscopy, dynamic light scattering and transmission electron microscopy...
2018: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29512729/curcumin-inhibits-superoxide-dismutase-induced-epithelial-to-mesenchymal-transition-via-the-pi3k-akt-nf-%C3%AE%C2%BAb-pathway-in-pancreatic-cancer-cells
#6
Wei Li, Zhengdong Jiang, Xue Xiao, Zheng Wang, Zheng Wu, Qingyong Ma, Lei Cao
Curcumin is a natural polyphenol compound derived from turmeric. It possesses multiple pharmacological properties, including antioxidant, anti-inflammatory and anti-tumor progression properties. Our recent study demonstrated that superoxide dismutase (SOD)-dependent production of hydrogen peroxide (H2O2) promoted the invasive and migratory activity of pancreatic cancer cells. However, whether curcumin suppresses SOD-induced cancer progression and the related mechanisms remains unclear. Since epithelial‑to-mesenchymal transition (EMT) plays a key role in tumor metastasis, the aim of the present study was to examine whether curcumin intervenes with SOD-induced EMT in pancreatic cancer and the underlying mechanism...
March 1, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29485738/curcumin-suppressed-the-prostate-cancer-by-inhibiting-jnk-pathways-via-epigenetic-regulation
#7
Wanli Zhao, Xudong Zhou, Guisong Qi, Yuexian Guo
Curcumin is a component of turmeric and is isolated from the rhizomes of the plant Curcuma longa. Curcumin was reported to have therapeutic effects on prostate cancer. Yet the molecular mechanism of curcumin remains unclear. In this study, mouse prostate cancer xenograft model was established and subjected to curcumin treatment. GST-c-Jun pull down kinase assays were performed to study the phospho-c-Jun level. Cell Counting Kit-8 assay kit was utilized to detect the cell viability. Immunoblotting and qRT-PCR were performed for target gene expression analysis...
February 27, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29476965/garlic-green-tea-and-turmeric-extracts-mediated-green-synthesis-of-silver-nanoparticles-phytochemical-antioxidant-and-in-vitro-cytotoxicity-studies
#8
D Arumai Selvan, D Mahendiran, R Senthil Kumar, A Kalilur Rahiman
Phyto-synthesis of silver nanoparticles (AgNPs) was achieved using aqueous garlic, green tea and turmeric extracts, and characterized by different spectroscopic techniques. Phytochemical analysis revealed the presence of rich amount of biochemicals in these extracts, which serve as reducing and capping agents for converting silver nitrate into AgNPs. FT IR spectroscopy confirmed the role of biomolecules in the bioreduction and efficient stabilization of AgNPs. UV-Vis DRS spectra showed a band around 450 nm characteristics of AgNPs...
February 14, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29448931/effects-of-different-extracts-of-curcumin-on-tpc1-papillary-thyroid-cancer-cell-line
#9
Angelica Perna, Antonio De Luca, Laura Adelfi, Tammaro Pasquale, Bruno Varriale, Teresa Esposito
BACKGROUND: The thyroid gland is one of the largest endocrine glands in the body. The vast majority of TCs (> 90%) originate from follicular cells and are defined as differentiated thyroid cancers (DTC) and the two histological subtypes are the papillary TC with its variants and the follicular TC. Curcumin possesses a wide variety of biological functions, and thanks to its properties, it has gained considerable attention due to its profound medicinal values (Prasad, Gupta, Tyagi, and Aggarwal, Biotechnol Adv 32:1053-1064, 2014)...
February 15, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29413610/genipin-stabilized-caseinate-chitosan-nanoparticles-for-enhanced-stability-and-anti-cancer-activity-of-curcumin
#10
Muhamad Alif Razi, Rie Wakabayashi, Yoshiro Tahara, Masahiro Goto, Noriho Kamiya
Nanoparticles formed by the assembly of protein and polysaccharides are of great interest for the delivery of hydrophobic molecules. Herein, the formation of genipin-crosslinked nanoparticles from caseinate (CS) and chitosan (CH) is reported for the delivery of curcumin, a polyphenolic compound from turmeric, to cells. Genipin-crosslinked CS-CH nanoparticles (G-CCNPs) having a diameter of ∼250 nm and a low polydispersity index showed excellent stability over a wide pH range, as indicated by dynamic light scattering and transmission electron microscopic measurements...
January 31, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29408497/a-transcriptomic-analysis-of-turmeric-curcumin-represses-the-expression-of-cholesterol-biosynthetic-genes-and-synergizes-with-simvastatin
#11
Linda Saxe Einbond, Fabiana Manservisi, Hsan-Au Wu, Michael Balick, Victoria Antonetti, Andrea Vornoli, Ilaria Menghetti, Fiorella Belpoggi, Stephen Redenti, Alan Roter
The spice turmeric (Curcuma longa L.) has a long history of use as an anti-inflammatory agent. The active component curcumin induces a variety of diverse biological effects and forms a series of degradation and metabolic products in vivo. Our hypothesis is that the field of toxicogenomics provides tools that can be used to characterize the mode of action and toxicity of turmeric components and to predict turmeric-drug interactions. Male Sprague-Dawley rats were treated for 4 days with turmeric root containing about 3% curcumin (comparable to what people consume in the fresh or dried root) or a fraction of turmeric enriched for curcumin (∼74%) and liver tissue collected for gene expression analysis...
February 3, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29404861/therapeutic-potential-of-curcumin-in-major-retinal-pathologies
#12
REVIEW
Krishi V Peddada, A'sha Brown, Vivek Verma, Marcella Nebbioso
PURPOSE: The retina is continually exposed to free radicals from its rich blood supply, numerous mitochondria, and photons of light which strike its surface. Most pathological processes that take place in the retina, such as inflammation, cell apoptosis, or angiogenesis, can hence involve free radicals directly or indirectly.  Since inflammatory and oxidative stress pathways underlie retinal pathology, compounds that address these factors are therefore natural choices for treatment. This review article summarizes and provides commentary on curcumin's therapeutic potential use in ophthalmology with principal focus on retinal dosorders...
February 5, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29374713/maspin-enhances-the-anticancer-activity-of-curcumin-in-hormone-refractory-prostate-cancer-cells
#13
Wan-Li Cheng, Chien-Yu Huang, Cheng-Jeng Tai, Yu-Jia Chang, Chin-Sheng Hung
BACKGROUND/AIM: Androgen deprivation therapy remains the principal treatment for patients with advanced prostate cancer, though, most patients will eventually develop hormone-refractory prostate cancer (HRPC). Androgen ablation mediated maspin-induction has been identified in cancer patients. However, the role of maspin on the anticancer activity of curcumin derived from turmeric (Curcuma longa) in HRPC cells has not been elucidated. MATERIALS AND METHODS: The anticancer action of curcumin in hormone-independent prostate cancer cells (DU145, and PC-3) was determined by measures of cell survival rate...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29370243/inhibition-of-ev71-by-curcumin-in-intestinal-epithelial-cells
#14
Hsing-I Huang, Chi-Chong Chio, Jhao-Yin Lin
EV71 is a positive-sense single-stranded RNA virus that belongs to the Picornaviridae family. EV71 infection may cause various symptoms ranging from hand-foot-and-mouth disease to neurological pathological conditions such as aseptic meningitis, ataxia, and acute transverse myelitis. There is currently no effective treatment or vaccine available. Various compounds have been examined for their ability to restrict EV71 replication. However, most experiments have been performed in rhabdomyosarcoma or Vero cells...
2018: PloS One
https://www.readbyqxmd.com/read/29368356/superior-anticancer-activity-is-demonstrated-by-total-extract-of-curcuma-longa-l-as-opposed-to-individual-curcuminoids-separated-by-centrifugal-partition-chromatography
#15
Wirginia Kukula-Koch, Aneta Grabarska, Jarogniew Łuszczki, Lidia Czernicka, Ewa Nowosadzka, Ewelina Gumbarewicz, Agata Jarząb, Gregoire Audo, Shakti Upadhyay, Kazimierz Głowniak, Andrzej Stepulak
Three curcuminoids: bisdemethoxycurcumin, demethoxycurcumin, and curcumin from turmeric were successfully separated by a high capacity solvent system composed of heptane: chloroform: methanol: water mixture (5: 6: 3: 2 v/v/v/v) tailored for centrifugal partition chromatographs at K-values of 0.504, 1.057, 1.644, respectively. These three ferulic acid derivatives obtained at a purity rate exceeding 95% were analysed by an HPLC-MS spectrometer. Turmeric extract inhibited the proliferation/viability of A549 human lung cancer, HT29 colon cancer, and T98G glioblastoma cell lines in (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay (MTT)...
January 24, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29361519/curcumin-and-derivatives-function-through-protein-phosphatase-2a-and-presenilin-orthologues-in-dictyostelium-discoideum
#16
Marco Cocorocchio, Amy J Baldwin, Balint Stewart, Lou Kim, Adrian J Harwood, Christopher R L Thompson, Paul L R Andrews, Robin S B Williams
Natural compounds often have complex molecular structures and unknown molecular targets. These characteristics make them difficult to analyse using a classical pharmacological approach. Curcumin, the main curcuminoid of turmeric, is a complex molecule possessing wide-ranging biological activities, cellular mechanisms and roles in potential therapeutic treatment, including Alzheimer's disease and cancer. Here, we investigate the physiological effects and molecular targets of curcumin in Dictyostelium discoideum We show that curcumin exerts acute effects on cell behaviour, reduces cell growth and slows multicellular development...
January 29, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29346317/liposomal-tricurin-a-synergistic-combination-of-curcumin-epicatechin-gallate-and-resveratrol-repolarizes-tumor-associated-microglia-macrophages-and-eliminates-glioblastoma-gbm-and-gbm-stem-cells
#17
Sumit Mukherjee, Juliet N E Baidoo, Samay Sampat, Andrew Mancuso, Lovena David, Leah S Cohen, Shuiqin Zhou, Probal Banerjee
Glioblastoma (GBM) is a deadly brain tumor with a current mean survival of 12-15 months. Despite being a potent anti-cancer agent, the turmeric ingredient curcumin (C) has limited anti-tumor efficacy in vivo due to its low bioavailability. We have reported earlier a strategy involving the use two other polyphenols, epicatechin gallate (E) from green tea and resveratrol (R) from red grapes at a unique, synergistic molar ratio with C (C:E:R: 4:1:12.5, termed TriCurin) to achieve superior potency against HPV+ tumors than C alone at C:E:R (μM): 32:8:100 (termed 32 μM+ TriCurin)...
January 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29339227/a-novel-biphenolic-ligand-for-selective-mg-2-and-zn-2-ions-sensing-followed-by-colorimetric-spectroscopic-and-cell-imaging-methods
#18
Palanisamy Uma Maheswari, Duraisamy Renuga, Linda Jeeva Kumari Henry, Kandasamy Ruckmani
The (E)-2-((2-hydrohy-5-methylphenylimino) methyl) phenol ligand was synthesized. The receptor was characterized by IR, 1 H and 13 C NMR and CHN analysis. The ligand exhibits colorimetric and fluorometric sensing of Zn2+ and Mg2+ ions in semi-aqueous medium (DMSO-H2O). The receptor was tested with series of transition metal ions (Cr2+ , Fe2+ , Ni2+ , Co2+ , Cu2+ , Zn2+ ) and heavy metal ions (Sn2+ , Pd2+ , Ce2+ , Hg2+ , Cd2+ ) and the essential human body elements like Ca2+ , Mg2+ , Na+ and K+ ions. The naked eye colorimetric sensing was absorbed only for Zn2+ and Mg2+ ...
April 30, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29318975/evaluation-of-the-antiproliferative-activity-of-some-nanoparticulate-essential-oils-formulated-in-microemulsion-on-selected-human-carcinoma-cell-lines
#19
Ahmed Abd-Rabou, Amr E Edris
BACKGROUND: Essential oils (EOs) are natural volatile plant extract that have different biological activities including antiproliferative potentials. OBJECTIVE: the current study aims at evaluating the antiproliferative activities of six EOs in their neat state compared to their nanoparticulate form after fabrication in microemulsion against some cancer cell lines. The EOs included marjoram (Origanum majorana), turmeric (Curcuma longa), sweet basil (Ocimum basillicum), clove buds (Syzygium aromaticum), geranium (plargonium graviolenis), and black cumin (Nigella sativa)...
January 10, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29258259/regulation-of-polyamine-metabolism-by-curcumin-for-cancer-prevention-and-therapy
#20
REVIEW
Tracy Murray-Stewart, Robert A Casero
Curcumin (diferuloylmethane), the natural polyphenol responsible for the characteristic yellow pigment of the spice turmeric ( Curcuma longa ), is traditionally known for its antioxidant, anti-inflammatory, and anticarcinogenic properties. Capable of affecting the initiation, promotion, and progression of carcinogenesis through multiple mechanisms, curcumin has potential utility for both chemoprevention and chemotherapy. In human cancer cell lines, curcumin has been shown to decrease ornithine decarboxylase (ODC) activity, a rate-limiting enzyme in polyamine biosynthesis that is frequently upregulated in cancer and other rapidly proliferating tissues...
December 18, 2017: Medical Sciences: Open Access Journal
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