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Vitamin d and cancer

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https://www.readbyqxmd.com/read/29332745/a-critical-overview-of-the-current-myofascial-pain-literature-january-2018
#1
REVIEW
Jan Dommerholt, Todd Hooks, Li-Wei Chou, Michelle Finnegan
The majority of papers included in the quarterly review discuss various aspects of dry needling (DN), which continues to be of interest to researchers and clinicians. A study by Liu et al. is the first paper to examine the effects of DN of acetylcholine, esterase and receptors. The study provides support for the integrated trigger point hypothesis and for DN. A paper by Hightower and colleagues found an intriguing link between low magnesium levels in the drink water supply, vitamin D, and myofascial pain, cancer, tendon ruptures, and colon polyps...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332325/is-%C3%AE-n-acetylgalactosaminidase-the-key-to-curing-cancer-a-mini-review-and-hypothesis
#2
Ehsan Saburi, Jalil Tavakol-Afshari, Sajjad Biglari, Yousef Mortazavi
In the constant battle against cancer cells, macrophages are of great importance. Their activation is achieved through various mechanisms such as Vitamin D binding protein (VDBP or Gc). After undergoing modifications via enzymes secreted by stimulated lymphocytes, VDBP is modified into Macrophages Activator Form/Factor (Gc-MAF). Some studies (particularly those focusing on cancer) have reported that an enzyme known as α-N-acetylgalactosaminidase (nagalase) facilitates the deglycosylation of Gc-MAF, which in turn inhibits the activation of macrophages...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29324909/effect-of-hypoparathyroid-on-bone-mineral-density-of-lumber-spine-in-postmenopausal-women-with-differentiated-thyroid-cancinoma
#3
Yongli Bai, Yanlei Huo, Fei Yu, Danyang Wang, Chao Ma
OBJECTIVE: To investigate the effect of hypoparathyroid on bone mineral density in postmenopausal women with differentiated thyroid carcinoma (DTC). SUBJECT AND METHODS: Postmenopausal women with postoperative DTC, and undergoing thyroid residual ablation or for metastases treatment were collected and followed for two years. They were divided into hypoparathyroid group (PTH<15pg/mL) and a normal cognitive group (PTH>15pg/mL). Bone mineral density (BMD) at the lumbar spine was analyzed using dual-energy X-ray absorptiometry (DXA) at baseline, 6, 12 and 24 months...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324674/calcitriol-supplementation-causes-decreases-in-tumorigenic-proteins-and-different-proteomic-and-metabolomic-signatures-in-right-versus-left-sided-colon-cancer
#4
Monica M Schroll, Katelyn R Ludwig, Kerry M Bauer, Amanda B Hummon
Vitamin D deficiency is a common problem worldwide. In particular, it is an issue in the Northern Hemisphere where UVB radiation does not penetrate the atmosphere as readily. There is a correlation between vitamin D deficiency and colorectal cancer incidence and mortality. Furthermore, there is strong evidence that cancer of the ascending (right side) colon is different from cancer of the descending (left side) colon in terms of prognosis, tumor differentiation, and polyp type, as well as at the molecular level...
January 11, 2018: Metabolites
https://www.readbyqxmd.com/read/29319256/myopathy-effect-of-vitamin-d-deficiency-beyond-bones
#5
Kavita J Rawat, Nilakshi H Sabnis, Udit Saraf, Gaurav Surana
Vitamin D functions as a vitamin as well as a hormone. Its major skeletal actions are complemented by varied extra-skeletal functions. During the past decade, association between Vitamin D and its role in various non-skeletal morbidities have been recognized. It plays a role in decreasing the risk of many chronic illnesses like allergies, asthma, autoimmune diseases, diabetes, cancers, infections and cardiovascular disease. We report the case of a middle aged female with chronic quadriparesis and new onset anemia associated with Vitamin D deficiency...
October 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29316620/could-aspirin-and-diets-high-in-fiber-act-synergistically-to-reduce-the-risk-of-colon-cancer-in-humans
#6
REVIEW
Pan Pan, Yi-Wen Huang, Kiyoko Oshima, Martha Yearsley, Jianying Zhang, Jianhua Yu, Mark Arnold, Li-Shu Wang
Early inhibition of inflammation suppresses the carcinogenic process. Aspirin is the most commonly used non-steroid anti-inflammatory drugs (NSAIDs), and it irreversibly inhibits cyclooxygenase-1 and -2 (COX1, COX2). Multiple randomized clinical trials have demonstrated that aspirin offers substantial protection from colon cancer mortality. The lower aspirin doses causing only minimal gastrointestinal disturbance, ideal for long-term use, can achieve only partial and transitory inhibition of COX2. Aspirin's principal metabolite, salicylic acid, is also found in fruits and vegetables that inhibit COX2...
January 6, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29315215/association-between-vitamin-d-genetic-risk-score-and-cancer-risk-in-a-large-cohort-of-u-s-women
#7
Paulette D Chandler, Deirdre K Tobias, Lu Wang, Stephanie A Smith-Warner, Daniel I Chasman, Lynda Rose, Edward L Giovannucci, Julie E Buring, Paul M Ridker, Nancy R Cook, JoAnn E Manson, Howard D Sesso
Some observational studies suggest an inverse association between circulating 25-hydroxyvitamin D (25OHD) and cancer incidence and mortality. We conducted a Mendelian randomization analysis of the relationship between a vitamin D genetic risk score (GRS, range 0-10), comprised of five single nucleotide polymorphisms (SNPs) of vitamin D status in the DHCR7, CYP2R1 and GC genes and cancer risk among women. Analysis was performed in the Women's Genome Health Study (WGHS), including 23,294 women of European ancestry who were cancer-free at baseline and followed for 20 years for incident cancer...
January 9, 2018: Nutrients
https://www.readbyqxmd.com/read/29311132/the-epidemiology-of-prostate-cancer
#8
Claire H Pernar, Ericka M Ebot, Kathryn M Wilson, Lorelei A Mucci
Prostate cancer is a major cause of disease and mortality among men, and each year 1.6 million men are diagnosed with and 366,000 men die of prostate cancer. In this review, we discuss the state of evidence for specific genetic, lifestyle, and dietary factors associated with prostate cancer risk. Given the biological heterogeneity of this cancer, we focus on risk factors for advanced or fatal prostate cancer. First, we provide descriptive epidemiology statistics and patterns for prostate cancer incidence and mortality around the world...
January 8, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29306659/breast-osteoblast-like-cells-a-reliable-early-marker-for-bone-metastases-from-breast-cancer
#9
Manuel Scimeca, Chiara Antonacci, Nicola Toschi, Elena Giannini, Rita Bonfiglio, Claudio Oreste Buonomo, Chiara Adriana Pistolese, Umberto Tarantino, Elena Bonanno
BACKGROUND: The development of bone metastasis from breast cancer results from a functional interaction between tumor cells and osteoclasts or osteoblasts. The main aim of this study was therefore to test the hypothesis that the appearance of breast osteoblast-like cells (BOLCs) in primary mammary lesions is a precursor (and hence an early predictor) of the formation of breast cancer metastases to bone. PATIENTS AND METHODS: In this study, we collected 64 breast infiltrating carcinomas, 50 breast benignant lesions, and 10 biopsies of bone metastasis selected from patients with infiltrated carcinoma...
December 5, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29305131/prevalence-and-predictors-of-low-serum-25-hydroxyvitamin-d-among-female-african-american-breast-cancer-survivors
#10
Patricia Sheean, Claudia Arroyo, Jennifer Woo, Linda Schiffer, Melinda Stolley
BACKGROUND: African-American breast cancer survivors commonly demonstrate low serum 25-hydroxyvitamin D (25(OH)D). Decreased cutaneous conversion, high levels of adiposity, and even breast cancer treatment may influence vitamin D status. Previous investigations have analyzed African-American women in aggregate with other breast cancer survivors and have not comprehensively addressed these influential factors. OBJECTIVES: To determine the prevalence of low serum 25(OH)D in an exclusively African-American cohort of female breast cancer survivors with overweight/obesity and to evaluate the role of ultraviolet (UV) light exposure, body composition, and dietary sources of vitamin D on serum 25(OH)D levels...
January 2, 2018: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29304901/indoor-tanning-a-gianus-bifrons-vitamin-d-and-human-cancer
#11
Giuseppe Lippi, Gianfranco Cervellin, Elisa Danese
Despite it is now undeniable that indoor tanning exposure is associated with a number of skin cancers, its favorable effects on vitamin D status may bear some underestimated and currently unexplored health benefits. Vitamin D is a fat-soluble vitamin naturally present in a limited number of foods, the concentration of which largely depends on ultraviolet (UV) B sources exposure in humans. A strong, graded, and inverse association has been documented between serum vitamin D and the risk of developing certain types of malignancy, especially colorectal, breast, lung, bladder, and kidney cancers...
2018: Advances in Clinical Chemistry
https://www.readbyqxmd.com/read/29300860/examination-of-vdr-rxr-drip205-interaction-intranuclear-localization-and-dna-binding-in-ras-transformed-keratinocytes-and-its-implication-for-designing-optimal-vitamin-d-therapy-in-cancer
#12
Sylvester Jusu, John F Presley, Chris Williams, Sanjoy Kumar Das, Bertrand Jean-Claude, Richard Kremer
RXR occupies a central position within the nuclear receptor superfamily serving as an obligatory partner to numerous other nuclear receptors including VDR. In the present study, we examined whether phosphorylation of RXRalpha at serine 260 affects VDR/RXR and DRIP205 coactivator recruitment, interactions and binding of the VDR/ hRXRα /DRIP205 complex to chromatin. Serine 260 is a critical amino acid on the human retinoid X receptor alpha (hRXRα) that is located in close spatial proximity to regions of coactivator and corepressor interactions...
December 28, 2017: Endocrinology
https://www.readbyqxmd.com/read/29298285/the-relationship-between-breast-cancer-treatment-tumour-type-and-vitamin-d-level-in-pre-and-postmenopausal-women
#13
Joanna Streb, Izabela Glanowska, Anna Streb, Joanna Szpor, Koleta Kryka, Paweł Potocki, Małgorzata Wójcik, Robert Jach
OBJECTIVE: Vitamin D deficiency has been linked to a higher risk of cancer. There is insufficient data regarding the influence of treatment on vitamin D status. The aim of this study was to compare pre- and post-treatment levels of 25(OH)D in premenopausal and postmenopausal women with breast cancer with a different receptor status (ER-estrogen receptors, PR-progesterone receptors) and in healthy controls. METHODS: 49 patients with breast cancer (23 premenopausal), and 28 healthy controls matched for age, menopausal status and BMI...
December 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29290565/serum-vitamin-d-levels-affect-pathologic-complete-response-in-patients-undergoing-neoadjuvant-systemic-therapy-for-operable-breast-cancer
#14
Akiko Chiba, Rachna Raman, Alexandra Thomas, Pierre-Jean Lamy, Marie Viala, Stephane Pouderoux, Sarah L Mott, Mary C Schroeder, Simon Thezenas, William Jacot
INTRODUCTION: There has been increasing interest in the potential benefit of vitamin D in improving breast cancer outcome. Preclinical studies suggest that vitamin D enhances chemotherapy-induced cell death. We investigated the impact of serum vitamin D levels during neoadjuvant chemotherapy (NAC) on the rates of achieving pathologic complete response (pCR) after breast cancer NAC. PATIENTS AND METHODS: Patients from 1 of 2 Iowa registries who had serum vitamin D level measured before or during NAC were included...
December 11, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29286613/vitamin-d-deficiency-associated-with-differentiated-thyroid-carcinoma-a-case-control-study
#15
Zahra Heidari, Mahdi Nikbakht, Mohammad Ali Mashhadi, Mahdi Jahantigh, Nasrin Mansournia, Vahid Sheikhi, Mohammad Ali Mansournia
Objective: In recent decades, the incidence of thyroid cancer has increased throughout the world. It is unclear whether factors such as vitamin D deficiency may have been involved in this increase. The present case-control study was conducted to examine any association between Vitamin D deficiency and thyroid cancers. Methods: The study was conducted on 85 patients with differentiated thyroid cancer diagnosed based on fine needle aspiration biopsy as the case group and 85 healthy controls. Serum levels of vitamin D were evaluated before thyroidectomy...
December 29, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29285754/oral-anticoagulation-in-people-with-cancer-who-have-no-therapeutic-or-prophylactic-indication-for-anticoagulation
#16
REVIEW
Lara A Kahale, Maram B Hakoum, Ibrahim G Tsolakian, Charbel F Matar, Maddalena Barba, Victor E D Yosuico, Irene Terrenato, Francesca Sperati, Holger Schünemann, Elie A Akl
BACKGROUND: Oral anticoagulants may improve the survival of people with cancer through both an antitumor effect and antithrombotic effect, yet increase the risk of bleeding. OBJECTIVES: To evaluate the efficacy and safety of oral anticoagulants in ambulatory people with cancer undergoing chemotherapy, hormonal therapy, immunotherapy or radiotherapy, but otherwise have no standard therapeutic or prophylactic indication for anticoagulation. SEARCH METHODS: We conducted a comprehensive literature search in February 2016 that included a major electronic search of Cochrane Central Register of Controlled Trials (CENTRAL) (2016, Issue 1), MEDLINE (Ovid) and Embase (Ovid); handsearching of conference proceedings; checking of references of included studies; a search for ongoing studies; and using the 'related citation' feature in PubMed...
December 29, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29282002/dietary-supplement-use-among-cancer-survivors-and-the-general-population-a-nation-wide-cross-sectional-study
#17
Sihan Song, Jiyoung Youn, Yun Jung Lee, Minji Kang, Taisun Hyun, YoonJu Song, Jung Eun Lee
BACKGROUND: Use of dietary supplements among cancer survivors is common and controversial, but information on the amount of nutrients from supplements among cancer survivors is limited. We examined the amount of nutrients and their contribution to total nutrient intake from supplements and compared these data between cancer survivors and cancer-free individuals. We also identified factors associated with supplement use among cancer survivors. METHODS: We identified 400 cancer survivors and 10,387 cancer-free individuals, aged ≥ 19 years, from the fifth Korea National Health and Nutrition Examination Survey (KNHANES) V-1, 2 (2010, 2011)...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29278636/immunohystochemical-expression-of-vitamin-d-receptor-in-development-stages-of-colorectal-carcinoma
#18
Nikica Šutalo, Snježana Tomić, Milenko Bevanda, Vedran Dragišić, Inga Marijanović, Joško Petričević, Ivanka Mikulić
BACKGROUND: Chemo preventive and antitumor role of vitamin D is manifested through genetic and non genetic ways with a powerful antproliferatory and proapopoptic effect, which is proven by numerous epidemiologic studies. The genetic activity of vitamin D is determined through vitamin D receptors (VDR), a member of stero-thyreoidal family of nuclear receptors, which with vitamin D form a cell nucleus complex responsible for the chemo preventive and antitumor effect. VDR in tissue cells is present in the cytoplasm and the nucleus and manifests its genetic activity after transfer from the cytoplasm to the nucleus...
December 2017: Psychiatria Danubina
https://www.readbyqxmd.com/read/29275468/targeting-myeloid-derived-suppressor-cells-in-cancer
#19
Waseem Anani, Michael R Shurin
Myeloid derived suppressor cells (MDSC) represent only a minor fraction of circulating blood cells but play an important role in tumor formation and progression. They are a heterogeneous group of cells that influence the tumor microenvironment by depletion of amino acids, oxidative stress, decreased trafficking of antitumor effector cells, and increased regulatory T and regulatory dendritic cell responses. Investigational treatment strategies targeting MDSCs have attempted to inhibit MDSC development and expansion (stem cell factor blockade, modulate of cell signaling, and target MDSC migration and recruitment), inhibit MDSC function (nitric oxide inhibition and reactive oxygen and nitrogen species inhibition), differentiate MDSCs into more mature cells (Vitamins A and D, all-trans retinoic acid, interleukin-2, toll-like receptor 9 inhibitors, taxanes, beta-glucan particles, tumor-derived exosome inhibition, and very small size proteoliposomes), and destroy MDSCs (cytotoxic agents, ephrin A2 degradation, anti-interleukin 13, and histamine blockers)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29258769/calcium-and-vitamin-d-in-human-health-hype-or-real
#20
REVIEW
Sunil J Wimalawansa, DSc Mohammed S Razzaque, Nasser M Al-Daghri
The incidence and the prevalence of vitamin D deficiency are increasing worldwide. It is estimated that over 50% of population in the world have low in vitamin D (i.e., hypovitaminosis D; levels below 30 ng/mL). 80% of our vitamin D requirement comes from the ultraviolet rays from sunlight, and for the remainder, we rely from the diet and supplements. The latter become important when one is exposing to less than optimal amounts of sunlight, inability of the skin to generate vitamin D efficiently, and/or having secondary causes that leads to increase catabolism of vitamin D...
December 16, 2017: Journal of Steroid Biochemistry and Molecular Biology
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