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Vitamin d and cancer

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https://www.readbyqxmd.com/read/28526240/endocrine-actions-of-vitamin-d-in-skin-relevance-for-photocarcinogenesis-of-non-melanoma-skin-cancer-and-beyond
#1
REVIEW
Jörg Reichrath, Roman Saternus, Thomas Vogt
The skin represents a pivotal organ for the human body's vitamin D endocrine system, being both the site of ultraviolet (UV)-B-induced vitamin D synthesis and a target tissue for the pluripotent effects of 1,25(OH)2D3 and other biologically active vitamin D metabolites. As many other steroid hormones, 1,25(OH)2D3 exerts its effects via two independent signal transduction pathways: the classical genomic and the non-genomic pathway. While non-genomic effects of 1,25(OH)2D3 are in part exerted via effects on intracellular calcium, genomic effects are mediated by the vitamin D receptor (VDR)...
May 16, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28521479/association-between-non-melanoma-and-melanoma-skin-cancer-rates-vitamin-d-and-latitude
#2
Miguel Rivas, Elisa Rojas, Gloria M Calaf, Marcela Barberán, Claudio Liberman, Marcelo De Paula Correa
Vitamin D synthesis takes place in the skin due to solar ultraviolet-B (UVB) radiation. Several studies have shown the association between low sun exposure, non-melanoma skin cancer (NMSC) and a lack of vitamin D synthesis. Since such synthesis in the body depends on the exposure of the skin to solar UVB radiation (290-320 nm), experimental measurements of this type of solar radiation are important. Tarapaca University in Arica, Chile, established a solar UV radiation laboratory in 2006 and since then this laboratory has performed systematic experimental solar UVB measurements using a calibrated biometer instrument...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28516265/the-vitamin-d-deficiency-pandemic-approaches-for-diagnosis-treatment-and-prevention
#3
REVIEW
Michael F Holick
Vitamin D deficiency and insufficiency is a global health issue that afflicts more than one billion children and adults worldwide. The consequences of vitamin D deficiency cannot be under estimated. There has been an association of vitamin D deficiency with a myriad of acute and chronic illnesses including preeclampsia, childhood dental caries, periodontitis, autoimmune disorders, infectious diseases, cardiovascular disease, deadly cancers, type 2 diabetes and neurological disorders. This review is to put into perspective the controversy surrounding the definition for vitamin D deficiency and insufficiency as well as providing guidance for how to treat and prevent vitamin D deficiency...
May 17, 2017: Reviews in Endocrine & Metabolic Disorders
https://www.readbyqxmd.com/read/28515107/a-randomized-double-blind-placebo-controlled-trial-of-the-effect-of-vitamin-d3-supplementation-on-breast-density-in-premenopausal-women
#4
Jacques Brisson, Sylvie Bérubé, Caroline Diorio, Benoit Masse, Julie Lemieux, Thierry Duchesne, Edgar Delvin, Reinhold Vieth, Martin J Yaffe, Jocelyne Chiquette
BACKGROUND: This double-blind, placebo-controlled parallel-group trial assessed whether oral supplementation with 1,000, 2,000 or 3,000 IU/day vitamin D3 over one year reduces percent mammographic breast density in premenopausal women. METHODS: The trial was conducted between October 2012 and June 2015, among premenopausal female volunteers from Quebec City (Quebec, Canada). Women were randomized with ratio 1:1:1:1 to one of four study arms (1,000, 2,000 or 3,000 IU/d vitamin D3 or placebo)...
May 17, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28504884/d-%C3%AE-tocopheryl-succinate-phosphatidyl-ethanolamine-conjugated-amphiphilic-polymer-based-nanomicellar-system-for-the-efficient-delivery-of-curcumin-and-to-overcome-multiple-drug-resistance-in-cancer
#5
Omkara Swami Muddineti, Preeti Kumari, Balaram Ghosh, Vladimir P Torchilin, Swati Biswas
Nanomedicines have emerged as a promising treatment strategy for cancer. Multiple drug resistance due to overexpression of various drug efflux transporters and upregulation of apoptotic inhibitory pathways in cancer cells are major barriers that limit the success of chemotherapy. Here, we developed a d-α-tocopherol (α-TOS)/lipid-based copolymeric nanomicellar system (VPM) by conjugating phosphatidyl ethanolamine (PE) and α-TOS with poly(ethylene glycol) (PEG) via an amino acid linkage. The synthesized polymers were characterized by Fourier transform IR, gas-phase chromatography, and (1)H and (13)C NMR spectroscopy...
May 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28502031/vitamin-d-and-plasma-cell-dyscrasias-reviewing-the-significance
#6
REVIEW
Nicholas Burwick
Monoclonal gammopathy of undetermined significance (MGUS) is a clonal plasma cell disorder and precursor disease to multiple myeloma and other related cancers. While MGUS is considered a benign disorder, with a low risk of disease progression, patients have altered bone microarchitecture and an increased risk of bone fracture. In addition, alterations in immune function are regularly found to correlate with disease activity. Vitamin D, an important hormone for bone and immune health, is commonly deficient in multiple myeloma patients...
May 13, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28492801/orthotopic-tumorgrafts-in-nude-mice-as-a-model-to-evaluate-calcitriol-effects-in-breast-cancer
#7
V C N Fonseca-Filho, M L H Katayama, E C Lyra, D A Maria, R A Basso, S Nonogaki, J M Guerra, S Maistro, J C G S Góes, M A A K Folgueira
Objectives: To establish a tumorgraft model, from freshly collected breast cancer samples, which were directly implanted in nude mice, to study calcitriol effects. Methods: Breast cancer samples collected from 12 patients were orthotopically implanted into nude mice. Animals were treated with weekly intratumoral injections of calcitriol 3 μg/Kg, which was previously shown to induce peak serum calcitriol levels in the predicted therapeutic range. Results: Success engraftment rate was 25%...
May 4, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28492143/a-direct-assay-for-measuring-free-25-hydroxyvitamin-d
#8
Heureux Nicolas, Ernst Lindhout, Leon Swinkels
Recent studies suggest that the concentration and genotype of vitamin D binding protein (VDBP) are important factors that determine the bioavailability of 25-hydroxyvitamin D [25(OH)D] in blood. Accumulating data indicate that, e.g., in pregnant women, hemodialysis patients, chronic kidney disease, liver failure, and bladder and pancreatic cancers, the measurement of free 25(OH)D in serum provides more relevant diagnostic information than measurement of total 25(OH)D. The aim of this study was to develop and validate an ELISA for direct measurement of free 25(OH)D in serum...
May 11, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28486651/vitamin-d-and-cancer-risk-and-mortality-state-of-the-science-gaps-and-challenges
#9
Alison M Mondul, Stephanie J Weinstein, Tracy M Layne, Demetrius Albanes
There has been substantial enthusiasm recently regarding the potential role of vitamin D in the primary and secondary prevention of cancer. Laboratory studies demonstrate a range of anticarcinogenic effects for vitamin D compounds, but human studies have yielded little consistent evidence supporting a protective association. Higher circulating levels of vitamin D (i.e., 25-hydroxyvitamin D or 25(OH)D) appear to be associated with reduced risk of colorectal and bladder malignancies, but higher risk of prostate and possibly pancreatic cancers, with no clear association for most other organ sites examined...
January 1, 2017: Epidemiologic Reviews
https://www.readbyqxmd.com/read/28483970/total-and-free-circulating-vitamin-d-and-vitamin-d-binding-protein-in-relation-to-colorectal-cancer-risk-in-a-prospective-study-of-african-americans
#10
Shaneda Warren Andersen, Xiao-Ou Shu, Qiuyin Cai, Nikhil K Khankari, Mark D Steinwandel, Peter W Jurutka, William J Blot, Wei Zheng
BACKGROUND: Previous studies rarely evaluated the associations between vitamin D binding protein and free vitamin D with colorectal cancer (CRC) risk. We assessed these biomarkers and total 25-hydroxyvitamin D in relation to CRC risk in a sample of African Americans. METHODS: Cases comprised 224 African American participants of the Southern Community Cohort Study diagnosed with incident CRC. Controls (N=440) were selected through incidence density sampling and matched to cases on age, sex, and race...
May 8, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28481952/identification-of-potential-new-treatment-response-markers-and-therapeutic-targets-using-a-gaussian-process-based-method-in-lapatinib-insensitive-breast-cancer-models
#11
Tapesh Santra, Sandra Roche, Neil Conlon, Norma O'Donovan, John Crown, Robert O'Connor, Walter Kolch
Molecularly targeted therapeutics hold promise of revolutionizing treatments of advanced malignancies. However, a large number of patients do not respond to these treatments. Here, we take a systems biology approach to understand the molecular mechanisms that prevent breast cancer (BC) cells from responding to lapatinib, a dual kinase inhibitor that targets human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR). To this end, we analysed temporal gene expression profiles of four BC cell lines, two of which respond and the remaining two do not respond to lapatinib...
2017: PloS One
https://www.readbyqxmd.com/read/28473860/epidemic-of-vitamin-d-deficiency-and-its-management-awareness-among-indian-medical-undergraduates
#12
Yangshen Lhamo, Preeta Kaur Chugh, Sandhya R Gautam, C D Tripathi
Vitamin D deficiency is prevalent across all age groups in epidemic proportions. The purpose of this study was to acquire a baseline assessment and create awareness among medical students regarding vitamin D. A cross-sectional, voluntary survey was conducted among undergraduate medical students. Data were collected using a questionnaire which assessed the level of knowledge students had with regard to where vitamin D comes from, what it does for health, how much is recommended, factors that affect its levels, and deficiency management...
2017: Journal of Environmental and Public Health
https://www.readbyqxmd.com/read/28471122/could-25-oh-vitamin-d-deficiency-be-a-reason-for-hpv-infection-persistence-in-cervical-premalignant-lesions
#13
Emre Özgü, Nafiye Yılmaz, Eralp Başer, Tayfun Güngör, Salim Erkaya, Halil İbrahim Yakut
Vitamin D is an essential precursor to the steroid hormone calcitriol which mainly regulates calcium homeostasis. Moreover anti- proliferative, pro- apoptotic, anti- angiogenic effects of Vitamin D support the ideas of preventive role in various cancer. This study aimed to determine if there is a relationship between HPVDNA infection and cervical intraepithelial neoplasia and Vitamin D deficiency. As a result of the study the difference of 25-OH Vitamin D3 levels between HPVDNA positive group and the control group were statistically significant (p=0,009)...
July 2016: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28469103/association-between-serum-25-hydroxy-vitamin-d-concentration-and-taqi-vitamin-d-receptor-gene-polymorphism-among-jordanian-females-with-breast-cancer
#14
Manar Fayiz Atoum, Yasmeen Mohammad Al-Khatib
BACKGROUND: Breast cancer is the most common type of cancer among females. Genetic polymorphisms might have a role in carcinogenesis. The aim of this study was to determine whether C to T base substitution within TaqI Vitamin D receptor (VDR) gene (rs731236) in exon 9 was a risk factor among patients with breast cancer. METHODS: Peripheral blood was drawn from 122 Jordanian breast cancer patients and 100 healthy Jordanian volunteers in Al-Basheer Hospital during the summer months (from June to November of 2013, 2014, and 2015)...
May 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28465245/1-25-dihydroxyvitamin-d3-suppresses-gastric-cancer-cell-growth-through-vdr-and-mutant-p53-mediated-induction-of-p21
#15
Mingxing Li, Longfei Li, Lin Zhang, Wei Hu, Jing Shen, Zhangang Xiao, Xu Wu, Franky Leung Chan, Chi Hin Cho
AIMS: Previous studies have indicated that vitamin D deficiency correlates with cancer risk and vitamin D potentiates antitumor effects in a variety of cancers. The antitumor effect of vitamin D on gastric cancer was rarely studied. We aimed to investigate the antitumor effect of vitamin D on gastric cancer and underlying mechanisms. MAIN METHODS: We investigated the antitumor activity of the active form of vitamin D, 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) on gastric cancer cells (TMK1) and immortalized normal gastric cells (HFE145) by using MTT, colony formation and Flow cytometry assays...
April 29, 2017: Life Sciences
https://www.readbyqxmd.com/read/28464481/correlation-of-mammographic-density-and-serum-calcium-levels-in-patients-with-primary-breast-cancer
#16
Carolin C Hack, Martin J Stoll, Sebastian M Jud, Katharina Heusinger, Werner Adler, Lothar Haeberle, Thomas Ganslandt, Felix Heindl, Rüdiger Schulz-Wendtland, Alexander Cavallaro, Michael Uder, Matthias W Beckmann, Peter A Fasching, Christian M Bayer
Percentage mammographic breast density (PMD) is one of the most important risk factors for breast cancer (BC). Calcium, vitamin D, bisphosphonates, and denosumab have been considered and partly confirmed as factors potentially influencing the risk of BC. This retrospective observational study investigated the association between serum calcium level and PMD. A total of 982 BC patients identified in the research database at the University Breast Center for Franconia with unilateral BC, calcium and albumin values, and mammogram at the time of first diagnosis were included...
May 2, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28460457/the-vitamin-d-receptor-is-involved-in-the-regulation-of-human-breast-cancer-cell-growth-via-a-ligand-independent-function-in-cytoplasm
#17
Trupti Trivedi, Yu Zheng, Pierrick G J Fournier, Sreemala Murthy, Sutha John, Suzanne Schillo, Colin R Dunstan, Khalid S Mohammad, Hong Zhou, Markus J Seibel, Theresa A Guise
Vitamin D has pleiotropic effects on multiple tissues, including malignant tumors. Vitamin D inhibits breast cancer growth through activation of the vitamin D receptor (VDR) and via classical nuclear signaling pathways. Here, we demonstrate that the VDR can also function in the absence of its ligand to control behaviour of human breast cancer cells both outside and within the bone microenvironment. Stable shRNA expression was used to knock down VDR expression in MCF-7 cells, generating two VDR knockdown clonal lines...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28460082/reducing-cancer-burden-in-the-population-an-overview-of-epidemiologic-evidence-to-support-policies-systems-and-environmental-changes
#18
Elizabeth A Platz
"Reducing Cancer Burden in the Population: Epidemiologic Evidence to Support Policies, Systems, and Environmental Changes" is a compilation of 11 reviews addressing aspects of primary prevention of cancer (early life factors, vitamin D, and periodontal disease and the oral microbiome); primary and secondary prevention (in the transgender population); surveillance following secondary prevention (personalizing follow-up of patients diagnosed with an adenoma based on colorectal cancer risk); tertiary prevention (physical activity as an adjuvant to cancer treatment, measurement of patient-reported physical functioning in cancer treatment trials, and implementation of palliative care recommendations); and all 3 (changing epidemiology of oral cancers)...
January 1, 2017: Epidemiologic Reviews
https://www.readbyqxmd.com/read/28459861/randomized-controlled-trials-of-vitamin-d-and-cancer-incidence-a-modeling-study
#19
William B Grant, Barbara J Boucher
Although geographic ecological studies and observational studies find that ultraviolet B exposure and 25-hydroxyvitamin D [25(OH)D] concentrations are inversely correlated with 15-20 types of cancer, few randomized controlled trials (RCTs) of vitamin D support those findings. The poor design of some RCTs may account for that lack of support. Most vitamin D RCTs to date have considered the vitamin D dose, rather than initial, final, or changes in, serum 25(OH)D concentrations. Here a model is developed for use in designing and analyzing vitamin D RCTs with application to cancer incidence...
2017: PloS One
https://www.readbyqxmd.com/read/28452288/25-oh-d-levels-in-trained-versus-sedentary-university-students-at-64%C3%A2-north
#20
Scott P Jerome, Kendra D Sticka, Theresia M Schnurr, Sally J Mangum, Arleigh J Reynolds, Kriya L Dunlap
PURPOSE: 25-hydroxyvitamin D (25[OH]D) deficiency is associated with compromised bone mineralisation, fatigue, suppressed immune function and unsatisfactory skeletal muscle recovery. We investigated the risk of 25(OH)D insufficiency or deficiency in endurance athletes compared to sedentary non-athletes living at 64° north. METHODS: University student-athletes (TS) and sedentary students (SS) volunteered to participate in this study. TS engaged in regular exercise while SS exercised no more than 20 minutes/week...
2017: International Journal of Circumpolar Health
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