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heart BMJ

Chezhan Hall, Maria Murphy, Andrew Scanlon
BACKGROUND: Phase one cardiac rehabilitation (CR) is an essential component of care for patients with coronary heart disease. With optimal program delivery, health outcomes can be improved. OBJECTIVES: To conduct an integrative review that explores Phase one CR for patients hospitalised with coronary heart disease. DESIGN: Integrative literature review (2003-2014) Data sources: The literature search included Medline, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Experta Medica Database (EMBASE), Psycinfo, Clinical Practice Guidelines Portal, Cochrane Library, Clinical Evidence (BMJ) and Google Scholar...
March 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
Charlotte Vrinten, Jane Wardle
OBJECTIVES: Despite improved outcomes, cancer remains widely feared, often because of its association with a long and protracted death as opposed to the quick death that people associate with that other common cause of adult mortality: heart disease. Former editor-in-chief of the BMJ Richard Smith's view that 'cancer is the best way to die' therefore attracted much criticism. We examined middle-aged and older adults' agreement with this view and compared their attitudes towards dying from cancer versus heart disease in terms of which was a good death...
March 2016: European Journal of Cancer
Marie Pantaleon
Although the culture requirements and the metabolic profile of the preimplantation embryo have been thoroughly investigated since their first successful culture in a defined medium, now more than 50 years ago (Whitten, Nature 177:96, 1956), it is only recently that we have begun to appreciate the impact of the environment on life-course trajectory. The mechanisms involved in how nutrient availability may potentially modulate developmental potential are consequently not well defined. Originally thought of as simple energy substrates and biosynthetic precursors, the currently emerging paradigm suggests that nutrients may act in non-classical roles to impact on developmental potential...
2015: Advances in Experimental Medicine and Biology
Abigail S Baldridge, Mark D Huffman, Gerald S Bloomfield, Dorairaj Prabhakaran
Studies have demonstrated strong associations between publication source and citations, as well as investigatory analysis of collaboration effects, in general and medical literature, but are limited to specific journals or short duration of time. This study sought to analyze time trends in cardiovascular research publications in leading general and specialty journals and to determine the association between collaboration and citation index. Cardiovascular publications were retrieved from Web of Knowledge by a cardiovascular bibliometric filter, and annual publication volumes in 8 general and specialty journals were compared...
June 2014: Global Heart
Marlies van Lent, John Overbeke, Henk Jan Out
BACKGROUND: Publication bias is generally ascribed to authors and sponsors failing to submit studies with negative results, but may also occur after submission. We evaluated whether submitted manuscripts on randomized controlled trials (RCTs) with drugs are more likely to be accepted if they report positive results. METHODS: Manuscripts submitted from January 2010 through April 2012 to one general medical journal (BMJ) and seven specialty journals (Annals of the Rheumatic Diseases, British Journal of Ophthalmology, Gut, Heart, Thorax, Diabetologia, and Journal of Hepatology) were included, if at least one study arm assessed the efficacy or safety of a drug and a statistical test was used to evaluate treatment effects...
2014: PloS One
James Eaton, Stuart Mealing, Juliette Thompson, Neil Moat, Pieter Kappetein, Nicolo Piazza, Rachele Busca, Ruben Osnabrugge
OBJECTIVES: Health Technology Assessment (HTA) agencies often undertake a review of economic evaluations of an intervention during an appraisal in order to identify published estimates of cost-effectiveness, to elicit comparisons with the results of their own model, and to support local reimbursement decision-making. The aim of this research is to determine whether Transcatheter Aortic Valve Implantation (TAVI) compared to medical management (MM) is cost-effective in patients ineligible for surgical aortic valve replacement (SAVR), across different jurisdictions and country-specific evaluations...
May 2014: Journal of Medical Economics
Martijn B Katan
A re-analysis of the Sydney Diet Heart Study (Ramsden et al., BMJ 2013) suggested that a diet high in linoleic acid increased the risk of coronary heart disease. The authors ascribe this to a lack of the omega-3 fatty acid, alpha-linolenic acid, in the oils and fats consumed. This argument has some weaknesses. Mortality in the linoleic acid group was 38 cases versus 27 in the control group (or 35 versus 28, or 39 versus 28; sources differ). The difference was significant in the current, though not in the original, publication...
2013: Nederlands Tijdschrift Voor Geneeskunde
Adam E Handel, Sunil V Patel, Julia Pakpoor, George C Ebers, Ben Goldacre, Sreeram V Ramagopalan
OBJECTIVES: To assess the extent to which funding and study design are associated with high reprint orders. DESIGN: Case-control study. SETTING: Top articles by size of reprint orders in seven journals, 2002-09. PARTICIPANTS: Lancet, Lancet Neurology, Lancet Oncology (Lancet Group), BMJ, Gut, Heart, and Journal of Neurology, Neurosurgery & Psychiatry (BMJ Group) matched to contemporaneous articles not in the list of high reprint orders...
2012: BMJ: British Medical Journal
J Kobr, K Pizingerova, L Sasek, J Fremuth, S Fikrlova
OBJECTIVE: Evidence-based medicine currently dictates that in children, the controlled hypothermia may be applied only to the first degree and only in cases of neonatal encephalopathy and acute brain injury. Current recommendations are limited in terms of indication as well as by their very low degree of relevance (47.1%). DATA SOURCE: The conclusions of published clinical and experimental studies, and ultimately the ongoing study of our clinical work. In our study, we monitored the core body temperature, brain bioelectrical potentials and infarction, heart rate, systemic venous and arterial pressure, cardiac output, hourly diuresis, and haemostasis parameters...
2011: Bratislavské Lekárske Listy
A Jurko, A Jurko, M Minarik
The myocardial performance index (MPI) is a simple quantitative, non-geometric index of ventricular function and is readily applicable for evaluation of the right and left ventricle function. The aim of the study was to assess normal MPI values in healthy children. We studied 38 healthy children from 3 to 18 years of age. The normal values of both, the left ventricular and right ventricular MPI were 0.32 +/- 0.07 and 0.27 +/- 0.09, respectively. Measurement of the MPI is non-invasive and easily obtainable and does not prolong the time required for examination...
2011: Bratislavské Lekárske Listy
L Gaspar, D Jurcova, I Ocadlik, M Makovnik, S Hlinstakova, M Bendzala, E Gasparova, M Fulleova, A Dukat
Arterial hypertension belongs to the most important factors of origin and lasting of tinnitus. We have studied 18 subjects suffering from tinnitus without the history of diagnosed or treated arterial hypertension. ABPM method was used for diagnosing arterial hypertension. 12 patients (66%) fulfilled the criteria for arterial hypertension. Our results illustrate that arterial hypertension diagnosis is devoted an insufficient attention in patients with tinnitus. ABPM should therefore be used in all patients with tinnitus, immediately after its manifestation and also repeatedly during its course...
2011: Bratislavské Lekárske Listy
J Maca, R Kula, J Jahoda, V Chylek, J Gumulec
Cardiac arrest (CA) is a serious clinical condition that might be responsible in many cases for death, in other at least for development of irreversible multiple organ dysfunctions. During and after the CA a significant coagulopathy develops causing a decrease in proper tissue perfusion even if an early return of spontaneous circulation (ROSC) is achieved (no-reflow phenomenon). Administration of thrombolytics can solve the problem by destructing the blood clot in both macrocirculation and microcirculation...
2010: Bratislavské Lekárske Listy
Letícia W Ribeiro, Carísi Anne Polanczyk
Evaluation of: Murphy AW, Cupples ME, Smith SM, Byrne M, Myrne MC, Newell J; for the SPHERE study team: Effect of tailored practice and patients care plans on secondary prevention of heart disease in general practice: cluster randomized controlled trial. BMJ 339, B4220 (2009). Coronary heart disease is the main cause of morbidity/mortality in developed countries and the costs of this epidemic are a major concern and a focus of public health policies. The cornerstone in controlling the incidence of coronary heart disease is the management of risk factors and an evaluation of the best strategy is of the greatest importance...
July 2010: Future Cardiology
M Erdede, A Denizbasi, O Onur, O Guneysel
OBJECTIVES: Positive blood cultures (BC) are considered a gold standard specific test for diagnosing and managing patients with community-acquired pneumonia (CAP). The aims of this study were to determine the positivity rate of BCs performed in patients with CAP, empirically started antibiotic regimens and conformity of the empirically started antibiotics with the results of BCs. METHODS: Patients with the diagnosis of CAP with started empiric antibiotic treatment and performed BC test were included in the study...
2010: Bratislavské Lekárske Listy
M Lezovic
BACKGROUND: Long-term care for people with chronic illnesses and disabilities present an urgent challenge around the world. METHODS: For the data collection from health care facilities, we used questionnaire method. RESULTS AND CONCLUSION: The return rate of questionnaire was very high, 70% questionnaires from health care facilities were returned. In health care facilities, the age structure of clients was highest in 76-85 years (41%), the length of stay of a patient in a healthcare facility was in 73% patients up to 3 weeks...
2009: Bratislavské Lekárske Listy
Bulent Eren, Recep Fedakar, Nursel Turkmen, Okan Akan
Hamam (Hot Bath) culture is prevalent worldwide. The high temperature and humidity of these places have multiple effects on human health. The aim of this study was to investigate the demographic characteristics, autopsy findings and causes of death of cases who died in hamam and underwent medicolegal autopsies. The study was performed on 15 cases who experienced sudden death or died suspiciously in hamam and autopsied between January 1999 and December 2004. Eleven cases were men and 4 were women. Mean age was 69...
2009: Bratislavské Lekárske Listy
M Bucova, J Lietava, F Mrazek, J Petrkova, P Penz, M Bernadic, T A Buckingham, M Petrek
We investigated the MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) in Slovak cohort of patients with ischemic heart disease (IHD). Our study comprised 270 patients with IHD, out of them 92 with myocardial infarction (MI). We found that the frequencies of the mutant GG genotype in Slovak patients with IHD (10.7%; p=0.019) and MI (12.0%; p=0.046) were significantly higher than those in the control subjects (5.8%). After subdividing the groups according to the sex, statistically significant difference was found only in men (IHD: p=0...
2009: Bratislavské Lekárske Listy
Kenan Yusifzade, Murat Akin, Ipek Isikgonul, Ozlem Gulbahar, Ahmet Ziya Anadol, Osman Kurukahvecioglu, Sevim Ercan, Mustafa Sare
BACKGROUND: Acute mesenteric ischemia is an entity characterized by rapid developing of circulatory failure. Reperfusion following ischemia causes further mucosal injury. METHODS: In our study, an experimental model of 15 minutes of reperfusion following 45 minutes of superior mesenteric artery occlusion was established. The segments which underwent I/R injury were histopathologically examined, and blood samples obtained from the heart were analyzed for alkaline phosphatase and creatine kinase levels...
2009: Bratislavské Lekárske Listy
R Gal, M Slezak, I Zimova, I Cundrle, H Ondraskova, D Seidlova
BACKGROUND: The objective of this study was to evaluate the impact of mild hypothermia (34-35 degrees C) on the final neurological outcome in patients after resuscitation from out-of-hospital cardiac arrest. METHODS: Forty three patients, admitted at University Hospital Brno after the out-of-hospital cardiac arrest, were included in the cohort study. The inclusion criteria were out-of-hospital cardiac arrest resulting from ventricular fibrillation or non-perfusing ventricular tachycardia as well as recovery of spontaneous circulation within 60 minutes after first symptoms...
2009: Bratislavské Lekárske Listy
G Valocik, P Mitro, L Druzbacka, I Valocikova
OBJECTIVES: This study was designed to identify an association between left atrial volume and systolic and diastolic functions of the left ventricle. BACKGROUND: Several studies have shown a relationship between the left atrial volume and different cardiovascular risk factors. METHODS: Transthoracic echocardiographic results of 268 patients (136 women and 132 men, mean age 60.2+/-17.3 years) were studied retrospectively. Key echocardiographic variables of systolic and diastolic function were related to the left atrial volume and its indexed value...
2009: Bratislavské Lekárske Listy
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