Jovana Cupovic, Sandra S Ring, Lucas Onder, Julia M Colston, Mechthild Lütge, Hung-Wei Cheng, Angelina De Martin, Nicholas M Provine, Lukas Flatz, Annette Oxenius, Elke Scandella, Philippe Krebs, Daniel Engeler, Paul Klenerman, Burkhard Ludewig
Pathogens and vaccines that produce persisting antigens can generate expanded pools of effector memory CD8+ T cells, described as memory inflation. While properties of inflating memory CD8+ T cells have been characterized, the specific cell types and tissue factors responsible for their maintenance remain elusive. Here, we show that clinically applied adenovirus vectors preferentially target fibroblastic stromal cells in cultured human tissues. Moreover, we used cell-type-specific antigen targeting to define critical cells and molecules that sustain long-term antigen presentation and T cell activity after adenovirus vector immunization in mice...
July 15, 2021: Nature Immunology