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JOURNAL ARTICLE
Tijs J Hoogteijling, Mohammad Abu Hilal, Giuseppe Zimmitti, Davit L Aghayan, Andrew G R Wu, Federica Cipriani, Salvatore Gruttadauria, Olivier Scatton, Tran Cong Duy Long, Paulo Herman, Marco V Marino, Vincenzo Mazzaferro, Adrian K H Chiow, Iswanto Sucandy, Arpad Ivanecz, Sung Hoon Choi, Jae Hoon Lee, Mikel Gastaca, Marco Vivarelli, Felice Giuliante, Andrea Ruzzenente, Chee Chien Yong, Mengqiu Yin, Constantino Fondevila, Mikhail Efanov, Zenichi Morise, Fabrizio Di Benedetto, Raffaele Brustia, Raffaele Dalla Valle, Ugo Boggi, David Geller, Andrea Belli, Riccardo Memeo, Alejandro Mejia, James O Park, Fernando Rotellar, Gi Hong Choi, Ricardo Robles-Campos, Xiaoying Wang, Robert P Sutcliffe, Johann Pratschke, Chung-Ngai Tang, Charing C N Chong, Mathieu D'Hondt, Kazuteru Monden, Santiago Lopez-Ben, T Peter Kingham, Alessandro Ferrero, Giuseppe Maria Ettorre, Daniel Cherqui, Xiao Liang, Olivier Soubrane, Go Wakabayashi, Roberto I Troisi, Ho Seong Han, Tan To Cheung, Atsushi Sugioka, Safi Dokmak, Kuo Hsin Chen, Rong Liu, David Fuks, Wanguang Zhang, Luca Aldrighetti, Bjørn Edwin, Brian K P Goh
BACKGROUND: In the last three decades, minimally invasive liver resection has been replacing conventional open approach in liver surgery. More recently, developments in neoadjuvant chemotherapy have led to increased multidisciplinary management of colorectal liver metastases with both medical and surgical treatment modalities. However, the impact of neoadjuvant chemotherapy on the surgical outcomes of minimally invasive liver resections remains poorly understood. METHODS: A multicenter, international, database of 4998 minimally invasive minor hepatectomy for colorectal liver metastases was used to compare surgical outcomes in patients who received neoadjuvant chemotherapy with surgery alone...
April 2, 2024: European Journal of Surgical Oncology
#22
JOURNAL ARTICLE
Dong-Feng Ge, Yang-Kun Wang, Shen-Lin Li, Xiong-Fei Zou, Ling-Chao Kong, Wei-Yi Deng, Su-Nan Wang
The purpose of this study was to explore the histopathological staging and differential diagnosis of marginal zone lymphoma in gastric mucosa-associated lymphoid tissue (MALT lymphoma). We performed detailed histomorphology and immunohistochemistry investigations as well as genetic testing on endoscopic biopsy and endoscopic mucosal resection specimens from 18 patients with gastric MALT lymphoma. We found that gastric MALT lymphoma typically begins as a small, isolated area outside the lymphoid follicular mantle zone or proliferates in a multifocal, patchy manner, gradually spreads to the interfollicular zone, forming diffuse proliferation, invades the gastric mucosal glands, and infiltrates or proliferates into the center of peripheral reactive lymphoid follicles...
April 2, 2024: European Journal of Gastroenterology & Hepatology
#23
JOURNAL ARTICLE
Frances Weston, Ben Carter, Nick Powell, Allan H Young, Calum D Moulton
Around 25% of patients with inflammatory bowel disease (IBD) have depressive symptoms, yet antidepressants have been poorly studied in IBD. We systematically searched IBD studies testing antidepressants in four databases. Outcomes were depressive symptoms, anxiety, IBD disease activity, quality of life (QoL) and adverse events. For randomized controlled trials (RCTs), we performed random-effects meta-analysis of the standardized mean difference (SMD) in posttreatment scores between antidepressant and placebo groups...
April 5, 2024: European Journal of Gastroenterology & Hepatology
#24
JOURNAL ARTICLE
Jingyu Liu, Tongxin Zhang, Xiao Liu, Qian Wang, Huawei Zhang
Previous observational studies have found that the gut microbiota is closely related to the pathogenesis of gastroesophageal reflux disease (GERD), while their causal relationship is unclear. A two-sample multivariate Mendelian randomization analysis was implemented to estimate the causal effect of gut microbiota on GERD. The gut microbiota aggregated statistics were derived from a meta-analysis of the largest available genome-wide association studies (GWAS) conducted by the MiBioGen alliance (n = 13 266)...
April 15, 2024: European Journal of Gastroenterology & Hepatology
#25
JOURNAL ARTICLE
William P Duggan, John Lenihan, Cillian Clancy, Deborah A McNamara, John P Burke
Transanal minimally invasive surgery (TAMIS) is a surgical alternative to proctectomy in the management of complex rectal polyps and early rectal cancers. In 2016, our institution introduced a TAMIS programme. The purpose of this study was to evaluate changes in practice and outcomes in our institution in the 3 years before and after the implementation of TAMIS. We conducted a retrospective analysis of a prospective database of patients who underwent proctectomy or TAMIS for the management of complex rectal polyps or early rectal cancers at our institution between 2013 and 2018...
April 5, 2024: European Journal of Gastroenterology & Hepatology
#26
JOURNAL ARTICLE
Maha Elsabaawy, Hanaa Badran, Amr Ragab, Rasha Abdelwahab, Eman Sayed, Sameh Afify, Warda Othman
OBJECTIVE: This study aimed to evaluate the impact of the combined Albumin-bilirubin (ALBI)/sarcopenia score as a newly developed prognostic model for hepatocellular carcinoma (HCC), with a focus on its utility in predicting mortality. METHODS: This prospective study was conducted on HCC patients who were followed for 1 year or until death. Sarcopenia was assessed radiologically by computed tomography at the level of L3. The study consisted of two sets: a development set in which the new ALBI-sarcopenia score was created, comprising 262 HCC patients, followed by an internal validation set with 100 patients...
April 17, 2024: European Journal of Gastroenterology & Hepatology
#27
JOURNAL ARTICLE
Alberto Amador, Silvia Salord, Xavier Xiol, Marta Garcia-Guix, Alba Cachero, Rosa Rota, Nerea Hernandez Aretxabaleta, Carme Baliellas, Jose Castellote
OBJECTIVE: A set of indicators has been reported to measure the quality of care for cirrhotic patients, and previously published studies report variable adherence rates to these indicators. This study aimed to assess the quality of care provided to cirrhotic outpatients before and after an educational intervention by determining its impact on adherence to quality indicators. METHODS: We conducted a quasi-experimental, cross-sectional study including 324 cirrhotic patients seen in 2017 and 2019 at a tertiary teaching hospital in Spain...
April 15, 2024: European Journal of Gastroenterology & Hepatology
#28
JOURNAL ARTICLE
Zhenya Sun, Lei Cao, Yusheng Chen, Weiming Zhu, Yi Li
There is a paucity of data on the surgical or medical treatment for abscess/fistula complicating Crohn's disease after successful nonsurgical management. We conducted a cohort study to investigate the long-term outcomes and the risk factors for the requirement of subsequent surgical intervention in Crohn's disease patients with complicating fistulas/abscess following successful nonsurgical management. Data were collected on penetrating Crohn's disease experiencing successful nonsurgical treatment between December 2012 and December 2021...
April 5, 2024: European Journal of Gastroenterology & Hepatology
#29
REVIEW
Ali Majlesara, Ehsan Aminizadeh, Ali Ramouz, Elias Khajeh, Mohammadamin Shahrbaf, Filipe Borges, Gil Goncalves, Carlos Carvalho, Mohammad Golriz, Arianeb Mehrabi
AIM: To evaluate the quantity and quality of randomized controlled trials (RCTs) in hepatobiliary surgery and for identifying gaps in current evidences. METHODS: A systematic search was conducted in MEDLINE (via PubMed), Web of Science, and Cochrane Controlled Register of Trials (CENTRAL) for RCTs of hepatobiliary surgery published from inception until the end of 2023. The quality of each study was assessed using the Cochrane risk-of-bias (RoB) tool. The associations between risk of bias and the region and publication date were also assessed...
April 16, 2024: European Journal of Clinical Investigation
#30
JOURNAL ARTICLE
Jaya Garg, Prashant Verma, Mridu Singh, Anupam Das, Anurag Pathak, Jyotsna Agarwal
BACKGROUND: The diagnosis and treatment monitoring of hepatitis C is quite challenging. The screening test, i.e. antibody assay, is unable to detect acute cases, while the gold standard hepatitis C virus (HCV) reverse transcriptase polymerase chain reaction (RTPCR) assay is not feasible in resource-limited countries such as India due to high cost and infrastructure requirement. European Association for the Study of the Liver and World Health Organization have approved a new marker, i...
April 15, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
#31
EDITORIAL
Markos Kalligeros, Emmanuel A Tsochatzis
No abstract text is available yet for this article.
April 3, 2024: Hepatobiliary Surgery and Nutrition
#32
REVIEW
Adam Khattak, Tahne Vongsavath, Lubaba Haque, Amrit Narwan, Robert G Gish
Hepatitis D virus (HDV) is an RNA subvirus that infects patients with co-existing hepatitis B virus (HBV) infections. HDV burden is estimated to be approximately 15-20 million people worldwide. Despite HDV severity, screening for HDV remains inadequate. HDV screening would benefit from a revamped approach that automatically reflexes testing when individuals are diagnosed with HBV if HBsAg-positive, to total anti-HDV, and then to quantitative HDV-RNA polymerase chain reaction (PCR) rather than only testing those at high risk sequentially...
2024: Journal of Clinical and Experimental Hepatology
#33
JOURNAL ARTICLE
Philippe Guerre, Elodie Lassallette, Ugo Beaujardin-Daurian, Angelique Travel
Poultry feed is often contaminated with fumonisins, deoxynivalenol, and zearalenone, which can result in oxidative damage, inflammation and change in lipid metabolism. Although sphingolipids play key roles in cells, only the effects of fumonisins on the sphingolipidome are well-documented. In chickens, fumonisins have been shown to increase the sphinganine to sphingosine ratio and the C22-24:C16 sphingolipid ratio, which has been proposed as a new biomarker of toxicity. In this study, we used UHPLC-MSMS targeted analysis to measure the effect of fusariotoxins on sphingolipids in the livers of chickens fed with diets containing fusariotoxins administered individually and in combination, at the maximum levels recommended by the European Commission...
April 12, 2024: Chemico-biological Interactions
#34
JOURNAL ARTICLE
Fabrizio Di Benedetto, Paolo Magistri, Francesca Marcon, Olivier Soubrane, Felipe Pedreira Mello, Joao Santos Coelho, Andre Renaldo Fernandez, Samuele Frassoni, Vincenzo Bagnardi, Ashish Singhal, Fernando Rotellar, Roberto Hernandez-Alejandro, Ruslan Alikhanov, Eduardo de Souza M Fernandes, Francois Cauchy, Paolo Muiesan, Stefano Di Sandro, Hugo Pinto Marques
INTRODUCTION: Involvement of the inferior vena cava (IVC) and hepatic veins (HV) has been considered a relative contraindication to hepatic resection for primary and metastatic liver tumors. However, patients affected by tumors extending to the IVC have limited therapeutic options and suffer worsening of quality of life due to IVC compression. METHODS: Cases of primary and metastatic liver tumors with vena cava infiltration from 10 international centers were collected (7 European, 1 US, 2 Brazilian, 1 Indian) were collected...
April 11, 2024: International Journal of Surgery
#35
JOURNAL ARTICLE
Junshuai Li, Jingjing Xie, Min Zhang, Zhuojun Xiao, Fan Zhang, Weiqing Huang, Yong Zhou, Weiqun Yan, Rong Zhang, Xiaoming Peng
PURPOSE: To compare the clinical characteristics, virus serotype, and outcome in cases of mild and severe enteroviral infection at a tertiary neonatal intensive care unit in China. METHODS: A retrospective analysis of cases hospitalized between June and August 2019. Samples (stool or throat swabs) were examined using reverse transcription polymerase chain reaction. Positive cases were divided into two groups: mild infection and severe infection. RESULTS: A total of 149 cases were assigned to one of two groups: mild infection (n = 104) and severe infection (n = 45)...
April 12, 2024: European Journal of Clinical Microbiology & Infectious Diseases
#36
JOURNAL ARTICLE
Farshad Abedi, Batool Zarei, Sepideh Elyasi
PURPOSE: Nowadays, it is largely accepted that albumin should not be used in hypoalbuminemia or for nutritional purpose. The most discussed indication of albumin at present is the resuscitation in shock states, especially distributive shocks such as septic shock. The main evidence-based indication is also liver disease. In this review, we provided updated evidence-based instruction for definite and potential indications of albumin administration in clinical practice, with appropriate dosing and duration...
April 12, 2024: European Journal of Clinical Pharmacology
#37
JOURNAL ARTICLE
Xinhai Huang, Wenlin Xu, Guilan Wu, Ruijuan Li, Ping Gu, Qiaowei Zheng, Xiumei Liu, Hengfen Dai, Xiangsheng Lin, Yuxin Liu, Xiaoming Du, Jun Su, Wang Zhang, Min Zhang, Zhu Zhu, Xiaohong Huang, Nianxu Huang, Jinhua Zhang
BACKGROUND: The efficacy and safety of direct oral anticoagulants (DOACs) in atrial fibrillation (AF) patients with impaired liver function (ILF) have not been sufficiently studied. The aim of this study was to evaluate the efficacy and safety of DOACs for stroke prevention in patients with AF and ILF. METHOD: This study was based on data from 15 centers in China, including 4,982 AF patients. The patients were divided into 2 subgroups based on their liver function status: patients with normal liver function (NLF)(n = 4213) and patients with ILF (n = 769)...
April 12, 2024: European Journal of Clinical Pharmacology
#38
REVIEW
Fausto Petrelli, Marcella Arru, Silvia Colombo, Matteo Cavallone, Fulvia Milena Cribiu', Viola Villardita, Paola Floris, Luciano Digiesi, Gabriele Severgnini, Mariana Teixeira Moraes, Barbara Conti, Andrea Celotti, Matteo Viti, Andrea Sozzi
INTRODUCTION: Mutations in the BRAF gene (BRAFmut) are associated with an unfavorable prognosis in patients with metastatic colorectal cancer (CRC). The aim of this meta-analysis was to evaluate the prognosis of colorectal cancer (CRC) patients with liver metastases and the potential benefits of liver resection in patients with BRAFmut CRC. MATERIAL AND METHODS: A systematic search of PubMed, Cochrane Central Controlled Trials, and Embase databases was conducted on May 31, 2023...
March 29, 2024: European Journal of Surgical Oncology
#39
REVIEW
Shantha R Valainathan, Qing Xie, Vicente Arroyo, Pierre-Emmanuel Rautou
Accurate prediction of survival in patients with cirrhosis is crucial, as patients who are unlikely to survive in the short-term need to be oriented to liver transplantation and to novel therapeutic approaches. Patients with acute decompensation of cirrhosis without or with organ dysfunction/failure, the so-called acute-on-chronic liver failure (ACLF), have a particularly high short-term mortality. Recognizing the specificity of this clinical situation, dedicated classifications and scores have been developed over the last 15 years, including variables (e...
April 9, 2024: Liver International: Official Journal of the International Association for the Study of the Liver
#40
JOURNAL ARTICLE
Chunyong Yang, Mei Sun, Yihui Yang, Yan Han, Xiulin Wu, Xianfeng Wu, Huilin Cao, Lin Chen, Yuhao Lei, Xiaoyan Hu, Yang Chen, Ziyang Zeng, Junhong Li, Xin Shu, Zhiyong Yang, Kaizhi Lu, Yujie Li, Xiaobo Wang, Bin Yi
BACKGROUND: Bone morphogenetic protein 9 (BMP9) is a hepatokine that plays a pivotal role in the progression of liver diseases. Moreover, an increasing number of studies have shown that BMP9 is associated with hepatopulmonary syndrome (HPS), but its role in HPS is unclear. Here, we evaluated the influence of CBDL on BMP9 expression and investigated potential mechanisms of BMP9 signalling in HPS. METHODS: We profiled the circulating BMP9 levels in common bile duct ligation-induced HPS rat model, and then investigated the effects and mechanisms of HPS rat serum on pulmonary vascular endothelial dysfunction in rat model, as well as in primarily cultured rat pulmonary microvascular endothelial cells...
April 9, 2024: European Journal of Clinical Investigation
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