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European study of the liver

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https://www.readbyqxmd.com/read/29785393/monitoring-methotrexate-induced-liver-fibrosis-in-patients-with-psoriasis-utility-of-transient-elastography
#1
REVIEW
Harriet S Cheng, Marius Rademaker
Increasingly, existing evidence indicates that methotrexate-associated liver injury is related to comorbid risk factors such as diabetes, alcoholism, and obesity, rather than to methotrexate itself. Despite this fact, significant effort continues to be expended in the monitoring of low-dose methotrexate in patients with psoriasis. The gold standard investigation has been liver biopsy, but this is associated with significant morbidity and mortality. As methotrexate-induced liver injury is uncommon, the risk/benefit ratio of liver biopsy has been questioned...
2018: Psoriasis: Targets and Therapy
https://www.readbyqxmd.com/read/29773899/management-of-acute-hcv-infection-in-the-era-of-direct-acting-antiviral-therapy
#2
REVIEW
Marianne Martinello, Behzad Hajarizadeh, Jason Grebely, Gregory J Dore, Gail V Matthews
The management of acute HCV infection has not been standardized following the availability of direct-acting antiviral agents (DAAs) for chronic HCV infection, and substantial uncertainty exists regarding the optimal treatment regimen and duration. Despite the lack of direct evidence, the 2016 American Association for the Study of Liver Diseases (AASLD)-Infectious Diseases Society of America (IDSA) guidelines supported "the same regimens for acute HCV as recommended for chronic HCV infection … owing to high efficacy and safety", whereas the 2016 European Association for the Study of the Liver (EASL) guidelines recommended sofosbuvir-ledipasvir, sofosbuvir-velpatasvir or sofosbuvir plus daclatasvir for 8 weeks in acute HCV infection, with a longer duration of 12 weeks recommended for those infected with HIV and/or baseline HCV RNA levels >1,000,000 IU/ml...
May 17, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29772884/validation-of-a-spatial-liver-fluke-model-under-field-conditions-in-ireland
#3
Amalia Naranjo Lucena, María Pía Munita Corbalán, Ana María Martínez-Ibeas, Guy McGrath, Riona Sayers, Grace Mulcahy, Annetta Zintl
Fasciola hepatica is the causative agent of fasciolosis, a global disease of a wide range of mammals, particularly sheep and cattle. Liver fluke infection causes annual losses estimated at around €2.5 billion to livestock and food industries worldwide. Various models have been developed to define risk factors and predict exposure to this liver fluke in ruminants in European countries, most of them based exclusively on data from dairy herds. The aim of this study was to validate a published theoretical baseline risk map of liver fluke exposure and cluster maps in Ireland, by including further explanatory variables and additional herd types that are spatially more widespread...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29762630/acute-on-chronic-liver-failure-in-china-rationale-for-developing-a-patient-registry-and-baseline-characteristics
#4
Wen-Yi Gu, Bao-Yan Xu, Xin Zheng, Jinjun Chen, Xian-Bo Wang, Yan Huang, Yan-Hang Gao, Zhong-Ji Meng, Zhi-Ping Qian, Feng Liu, Xiao-Bo Lu, Jia Shang, Hai Li, Shao-Yang Wang, Xin Sun, Hai Li
Definitions and descriptions of acute-on-chronic liver failure (ACLF) vary between Western and Eastern types, and alcoholism and hepatitis B virus(HBV) are the main etiologies, respectively. To determine whether there are unified diagnostic criteria and common treatment programs for different etiologies of ACLF, a multicenter prospective cohort with the same inclusion criteria and disease indicators as those used in the European CANONIC (Chronic liver failure-ACLF in Cirrhosis) study is urgently needed in Asia, where the prevalence of HBV is high...
May 14, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29755775/rectal-and-anal-canal-neuroendocrine-tumours
#5
Teresa Raposo André, Margarida Brito, João Geraldes Freire, António Moreira
Neuroendocrine tumors (NETs) are rare, representing 0.5% of all newly diagnosed malignancies. Rectal and anal canal (AC) NETs account for less than 1% of all rectal and AC cancers. Review our institutional experience on NET of the rectum and AC, with emphasis on demographic, histological and treatment features and oncologic outcomes. The study group was identified from the Portuguese Regional South Oncological Registry. From 2000 to 2014, 22 patients with rectal or AC NETs were treated at our institution. Medical records were retrospectively reviewed...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29753211/lc-ms-ms-method-for-determination-of-cyclin-dependent-kinase-inhibitors-bp-14-and-bp-20-and-its-application-in-pharmacokinetic-study-in-rat
#6
Jitka Široká, Martina Čečková, Lubor Urbánek, Vladimír Kryštof, Tomáš Gucký, Jakub Hofman, Miroslav Strnad, František Štaud
N2 -(4-Amino-cyclohexyl)-9-cyclopentyl-N6 -(6-furan-2-yl-pyridine-3-ylmethyl)-9H-purine-2,6-diamine (BP-14) and 2-(5-{[2-(4-amino-cyclohexylamino)-9-cyclopentyl-9H-purine-6-ylamino]-methyl}-pyridine-2-yl)-phenol (BP-20) are novel cyclin-dependent kinase inhibitors, structurally related to roscovitine, with significant biological activity. A simple, selective and sensitive liquid chromatography - tandem mass spectrometry method for determining them in rat plasma, using roscovitine as an internal standard, was developed and validated...
May 1, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29751763/harm-reduction-and-viral-hepatitis-c-in-european-prisons-a-cross-sectional-survey-of-25-countries
#7
Rob Bielen, Samya R Stumo, Rachel Halford, Klára Werling, Tatjana Reic, Heino Stöver, Geert Robaeys, Jeffrey V Lazarus
BACKGROUND: Current estimates suggest that 15% of all prisoners worldwide are chronically infected with the hepatitis C virus (HCV), and this number is even higher in regions with high rates of injecting drug use. Although harm reduction services such as opioid substitution therapy (OST) and needle and syringe programs (NSPs) are effective in preventing the further spread of HCV and HIV, the extent to which these are available in prisons varies significantly across countries. METHODS: The Hep-CORE study surveyed liver patient groups from 25 European countries in 2016 and mid-2017 on national policies related to harm reduction, testing/screening, and treatment for HCV in prison settings...
May 11, 2018: Harm Reduction Journal
https://www.readbyqxmd.com/read/29750389/delisting-hcv-infected-liver-transplant-candidates-who-improved-after-viral-eradication-outcome-2-years-after-delisting
#8
Giovanni Perricone, Christophe Duvoux, Marina Berenguer, Paolo A Cortesi, Carmen Vinaixa, Rita Facchetti, Chiara Mazzarelli, Susanne Rasoul-Rockenschaub, Silvia Martini, Cristina Morelli, Sara Monico, Riccardo Volpes, Georges-Philippe Pageaux, Stefano Fagiuoli, Luca S Belli
BACKGROUNDS AND AIMS: Treating patients with decompensated cirrhosis with direct-acting antiviral (DAA) therapy while on the waiting list for liver transplantation, results in substantial improvement of liver function allowing one in four patients to be removed from the waiting list or delisted, as reported in a previous study promoted by the European Liver and Intestine Transplant Association (ELITA). Aim of this study was to report on clinical outcomes of delisted patients, including mortality risk, hepatocellular-carcinoma development, and clinical de-compensation requiring relisting...
May 11, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29742700/characteristics-and-management-of-pyogenic-liver-abscess-a-european-experience
#9
Cristina Serraino, Chiara Elia, Christian Bracco, Gianluca Rinaldi, Fulvio Pomero, Alberto Silvestri, Remo Melchio, Luigi Maria Fenoglio
Pyogenic liver abscess (PLA) are space-occupying lesions in the liver associated with high morbidity and mortality. The aim of this study is to review an Italian hospital experience in epidemiological, clinical patterns, and management of PLA.We performed a retrospective, descriptive case series at a single center assessing demographic characteristics, presentation patterns, etiological factors, microbiological etiology, and management for patients treated for PLA between 2000 and 2016.Around 109 patients were identified...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29737513/development-and-validation-of-a-difficulty-score-to-predict-intraoperative-complications-during-laparoscopic-liver-resection
#10
M C Halls, G Berardi, F Cipriani, L Barkhatov, P Lainas, S Harris, M D'Hondt, F Rotellar, I Dagher, L Aldrighetti, R I Troisi, B Edwin, M Abu Hilal
BACKGROUND: Previous studies have demonstrated that patient, surgical, tumour and operative variables affect the complexity of laparoscopic liver resections. However, current difficulty scoring systems address only tumour factors. The aim of this study was to develop and validate a predictive model for the risk of intraoperative complications during laparoscopic liver resections. METHODS: The prospectively maintained databases of seven European tertiary referral liver centres were compiled...
May 8, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29725696/-autoimmune-hepatitis-standard-and-second-line-therapy
#11
REVIEW
R Taubert, E Jaeckel
BACKGROUND: Autoimmune hepatitis (AIH) is a rare chronic inflammatory liver disease. Like other autoimmune diseases, the incidence continues to rise and, if left untreated, it has a detrimental natural course. AIM: Description of the current etiology, diagnosis and management of AIH. MATERIALS AND METHODS: Summary of current national as well as international guidelines and highlighting recently published studies. RESULTS AND CONCLUSION: In addition to autoantibody testing and liver histology, the diagnosis of AIH is based on the exclusion of other relevant liver diseases...
May 3, 2018: Der Internist
https://www.readbyqxmd.com/read/29723978/ergot-alkaloids-at-doses-close-to-eu-regulatory-limits-induce-alterations-of-the-liver-and-intestine
#12
Viviane Mayumi Maruo, Ana Paula Bracarense, Jean-Paul Metayer, Maria Vilarino, Isabelle P Oswald, Philippe Pinton
An increase in the occurrence of ergot alkaloids (EAs) contamination has been observed in North America and Europe in recent years. These toxins are well known for their effects on the circulatory and nervous systems. The aim of this study was to investigate the effect of EAs on the liver and on the intestine using the pig both as a target species and as a non-rodent model for human. Three groups of 24 weaned piglets were exposed for 28 days to control feed or feed contaminated with 1.2 or 2.5 g of sclerotia/kg, i...
May 1, 2018: Toxins
https://www.readbyqxmd.com/read/29721798/effects-of-the-chloro-s-triazine-herbicide-terbuthylazine-on-dna-integrity-in-human-and-mouse-cells
#13
Davor Želježić, Suzana Žunec, Marija Bjeliš, Vesna Benković, Marin Mladinić, Blanka Lovaković Tariba, Ivan Pavičić, Ana Marija Marjanović Čermak, Vilena Kašuba, Mirta Milić, Alica Pizent, Ana Lucić Vrdoljak, Nevenka Kopjar
Terbuthylazine belongs to the chloro-s-triazine group of herbicides and acts primarily as a photosynthesis inhibitor. The mechanisms of action related to its exposure, relevant both in animals and humans, are still insufficiently investigated. This comprehensive study focused on the outcomes of terbuthylazine exposure at cell level in vitro, and a mice model in vivo. Experiments in vitro were conducted on whole human peripheral blood, isolated lymphocytes, and HepG2 cells exposed for 4 h to terbuthylazine at 8...
May 2, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29718253/adverse-effects-of-statin-therapy-perception-vs-the-evidence-focus-on-glucose-homeostasis-cognitive-renal-and-hepatic-function-haemorrhagic-stroke-and-cataract
#14
François Mach, Kausik K Ray, Olov Wiklund, Alberto Corsini, Alberico L Catapano, Eric Bruckert, Guy De Backer, Robert A Hegele, G Kees Hovingh, Terry A Jacobson, Ronald M Krauss, Ulrich Laufs, Lawrence A Leiter, Winfried März, Børge G Nordestgaard, Frederick J Raal, Michael Roden, Raul D Santos, Evan A Stein, Erik S Stroes, Paul D Thompson, Lale Tokgözoglu, Georgirene D Vladutiu, Baris Gencer, Jane K Stock, Henry N Ginsberg, M John Chapman
Aims: To objectively appraise evidence for possible adverse effects of long-term statin therapy on glucose homeostasis, cognitive, renal and hepatic function, and risk for haemorrhagic stroke or cataract. Methods and results: A literature search covering 2000-2017 was performed. The Panel critically appraised the data and agreed by consensus on the categorization of reported adverse effects. Randomized controlled trials (RCTs) and genetic studies show that statin therapy is associated with a modest increase in the risk of new-onset diabetes mellitus (about one per thousand patient-years), generally defined by laboratory findings (glycated haemoglobin ≥6...
April 27, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29705030/adherence-to-quality-criteria-improves-concordance-between-transient-elastography-and-elastpq-for-liver-stiffness-assessment-a-multicenter-retrospective-study
#15
Giovanna Ferraioli, Annalisa De Silvestri, Thomas Reiberger, Simon D Taylor-Robinson, Robert J de Knegt, Laura Maiocchi, Ruxandra Mare, Theresa Bucsics, Sebastiana Atzori, Carmine Tinelli, Ioan Sporea
BACKGROUND: Assessment of liver stiffness provides important diagnostic and prognostic information in patients with chronic liver disease. AIMS: To investigate whether the use of quality criteria (i) improves the concordance between transient elastography (TE) and a novel point shear wave elastography technique (ElastPQ® ) and (ii) impacts on the performance of ElastPQ® for liver fibrosis staging using TE as the reference standard. METHODS: In this multicenter retrospective study, data of patients undergoing liver stiffness measurements (LSM) in five European centers were collected...
April 4, 2018: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29696193/a-prospective-development-study-of-software-guided-radio-frequency-ablation-of-primary-and-secondary-liver-tumors-clinical-intervention-modelling-planning-and-proof-for-ablation-cancer-treatment-clinicimppact
#16
Martin Reinhardt, Philipp Brandmaier, Daniel Seider, Marina Kolesnik, Sjoerd Jenniskens, Roberto Blanco Sequeiros, Martin Eibisberger, Philip Voglreiter, Ronan Flanagan, Panchatcharam Mariappan, Harald Busse, Michael Moche
Introduction: Radio-frequency ablation (RFA) is a promising minimal-invasive treatment option for early liver cancer, however monitoring or predicting the size of the resulting tissue necrosis during the RFA-procedure is a challenging task, potentially resulting in a significant rate of under- or over treatments. Currently there is no reliable lesion size prediction method commercially available. Objectives: ClinicIMPPACT is designed as multicenter-, prospective-, non-randomized clinical trial to evaluate the accuracy and efficiency of innovative planning and simulation software...
December 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29694286/primary-nonadherence-to-oral-anticoagulants-in-patients-with-atrial-fibrillation-real-world-data-from-a-population-based-cohort
#17
Clara L Rodriguez-Bernal, Salvador Peiró, Isabel Hurtado, Aníbal García-Sempere, Gabriel Sanfélix-Gimeno
BACKGROUND: Primary nonadherence (not filling a first prescription) is an important yet unstudied aspect of adherence to oral anticoagulant (OAC) therapy. OBJECTIVE: To estimate the rates of primary nonadherence to OACs and determine associated factors in real-world practice. METHODS: This population-based retrospective cohort study set in the Valencia region of Spain (about 5 million inhabitants) included all patients with atrial fibrillation who were newly prescribed OACs during 2011-2014 (N = 18,715)...
May 2018: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/29688155/radiation-segmentectomy-potential-curative-therapy-for-early-hepatocellular-carcinoma
#18
Robert J Lewandowski, Ahmed Gabr, Nadine Abouchaleh, Rehan Ali, Ali Al Asadi, Ronald A Mora, Laura Kulik, Daniel Ganger, Kush Desai, Bartley Thornburg, Samdeep Mouli, Ryan Hickey, Juan Carlos Caicedo, Michael Abecassis, Ahsun Riaz, Riad Salem
Purpose To report long-term outcomes of radiation segmentectomy (RS) for early hepatocellular carcinoma (HCC). The authors hypothesized that outcomes are comparable to curative treatments for patients with solitary HCC less than or equal to 5 cm and preserved liver function. Materials and Methods This retrospective study included 70 patients (median age, 71 years; range, 22-96 years) with solitary HCC less than or equal to 5 cm not amenable to percutaneous ablation who underwent RS (dose of >190 Gy) between 2003 and 2016...
April 24, 2018: Radiology
https://www.readbyqxmd.com/read/29686473/platelet-to-lymphocyte-ratio-in-the-setting-of-liver-transplantation-for-hepatocellular-cancer-a-systematic-review-and-meta-analysis
#19
Quirino Lai, Fabio Melandro, Zoe Larghi Laureiro, Francesco Giovanardi, Stefano Ginanni Corradini, Flaminia Ferri, Redan Hassan, Massimo Rossi, Gianluca Mennini
AIM: To perform a systematic review and meta-analysis on platelet-to-lymphocyte ratio (PLR) as a risk factor for post-transplant hepatocellular cancer (HCC) recurrence. METHODS: A systematic literature search was performed using PubMed. Participants of any age and sex, who underwent liver transplantation for HCC were considered following these criteria: (1) studies comparing pre-transplant low vs high PLR values; (2) studies reporting post-transplant recurrence rates; and (3) if more than one study was reported by the same institute, only the most recent was included...
April 21, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29669701/crizotinib-in-patients-with-advanced-inoperable-inflammatory-myofibroblastic-tumours-with-and-without-anaplastic-lymphoma-kinase-gene-alterations-european-organisation-for-research-and-treatment-of-cancer-90101-create-a-multicentre-single-drug-prospective-non
#20
Patrick Schöffski, Jozef Sufliarsky, Hans Gelderblom, Jean-Yves Blay, Sandra J Strauss, Silvia Stacchiotti, Piotr Rutkowski, Lars H Lindner, Michael G Leahy, Antoine Italiano, Nicolas Isambert, Maria Debiec-Rychter, Raf Sciot, Thomas Van Cann, Sandrine Marréaud, Axelle Nzokirantevye, Sandra Collette, Agnieszka Wozniak
BACKGROUND: An inflammatory myofibroblastic tumour (IMFT) is a rare mesenchymal neoplasm characterised by anaplastic lymphoma kinase (ALK) gene rearrangements. We assessed the activity and safety of crizotinib, a tyrosine kinase inhibitor, targeting ALK in patients with advanced IMFT either with or without ALK alterations. METHODS: We did a multicentre, biomarker-driven, single-drug, non-randomised, open-label, two-stage phase 2 trial (European Organisation for Research and Treatment of Cancer 90101 CREATE) at 13 study sites (five university hospitals and eight specialty clinics) in eight European countries (Belgium, France, Germany, Italy, Netherlands, Poland, Slovakia, and the UK)...
April 12, 2018: Lancet Respiratory Medicine
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