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European study of the liver

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https://www.readbyqxmd.com/read/28807289/neglected-intravascular-pathogens-babesia-vulpes-and-haemotropic-mycoplasma-spp-in-european-red-fox-vulpes-vulpes-population
#1
Martina Koneval, Martina Miterpáková, Zuzana Hurníková, Lucia Blaňarová, Bronislava Víchová
Wild animals, especially canids, are important reservoirs of vector-borne pathogens, that are transmitted by the ticks and other bloodsucking arthropods. In total, 300 red foxes (Vulpes vulpes), shot by the hunters in eastern and northern Slovakia, were screened for the presence of vector-borne pathogens by PCR-based methods Blood samples were obtained from nine red foxes and tissue samples originated from 291 animals (the liver tissue samples from 49 foxes and spleen samples from 242 red foxes). Babesia vulpes and haemotropic Mycoplasma species were identified by amplification and sequencing of 18S rRNA and 16S rRNA gene fragments, respectively...
August 30, 2017: Veterinary Parasitology
https://www.readbyqxmd.com/read/28807246/hepatic-intra-arterial-injection-of-irinotecan-drug-eluting-beads-debiri-for-patients-with-unresectable-colorectal-liver-metastases-a%C3%A2-systematic-review
#2
REVIEW
Olaguoke Akinwande, Meaghan Dendy, Johannes M Ludwig, Hyun S Kim
PURPOSE: To systematically review the safety and efficacy of transarterial drug-eluting beads, irinotecan (DEBIRI) for the treatment of pretreated patients with unresectable colorectal liver metastases (CRLM). METHODS: A systematic search of the current literature was conducted to extract publications reporting on the use of DEBIRI for CRLM. Data on the safety and efficacy was extracted and tabulated. Weighted average values (WAV) were calculated for each variable to provide a single value representing the pooled safety and efficacy data...
September 2017: Surgical Oncology
https://www.readbyqxmd.com/read/28801180/obesity-as-predictor-of-postoperative-outcomes-in-liver-transplant-candidates-review-of-the-literature-and-future-perspectives
#3
REVIEW
Michele Barone, Maria Teresa Viggiani, Alfonso W Avolio, Andrea Iannone, Maria Rendina, Alfredo Di Leo
BACKGROUND: Current American and European guidelines consider a pre-transplant BMI ≥40kg/m(2) as a relative contraindication for liver transplantation but this recommendation is graded as uncertain and requires further research. Moreover, conflicting results are reported on the predictive value of BMI 30-39.9kg/m(2) on post-transplant complication and mortality risk. AIM: This study analyzed the data of the literature on the effect of all three BMI classes of obesity on postoperative outcomes in liver transplantation...
July 22, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28799578/nusinersen-antisense-oligonucleotide-to-increase-smn-protein-production-in-spinal-muscular-atrophy
#4
D M Paton
Patients with spinal muscular atrophy (SMA) have an autosomal recessive disease that limits their ability to produce survival motor neuron (SMN) protein in the CNS resulting in progressive wasting of voluntary muscles. Detailed studies over several years have demonstrated that phosphorothioate and 2'-O-methoxyethyl- modified antisense oligonucleotides (ASOs) targeting the ISS-N1 site increase SMN2 exon 7 inclusion, thus increasing levels of SMN protein in a dose- and time-dependent manner in liver, kidney and skeletal muscle, and CNS tissues only when administered intrathecally...
June 2017: Drugs of Today
https://www.readbyqxmd.com/read/28799103/bleeding-recurrence-and-mortality-following-interventional-management-of-spontaneous-hcc-rupture-results-of-a-multicenter-european-study
#5
Lilian Schwarz, Michael Bubenheim, Johanna Zemour, Astrid Herrero, Fabrice Muscari, Ahmet Ayav, Romain Riboud, Christian Ducerf, J-Marc Regimbeau, Hadrien Tranchart, Emilie Lermite, Gheorghe Petrovai, Amal Suhol, Alexandre Doussot, Lorenzo Capussotti, Jean Jacques Tuech, Yves Patrice Le Treut
BACKGROUND: The incidence of spontaneous rupture of hepatocellular carcinoma (HCC) is low in Europe, at less than 3%. HCC rupture remains a life-threatening complication, with mortality reported between 16 and 30%. The risk of bleeding recurrence has never been clearly evaluated in such clinical situation. The objectives of this study were to evaluate the current risk of mortality related to HCC rupture and to focus on the risk of bleeding recurrence following interventional management...
August 10, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28795053/transarterial-chemoembolization-for-the-treatment-of-hepatocellular-carcinoma-a-review
#6
REVIEW
Rodolfo Sacco, Gherardo Tapete, Natalia Simonetti, Rossella Sellitri, Veronica Natali, Sara Melissari, Giuseppe Cabibbo, Lilia Biscaglia, Giampaolo Bresci, Luca Giacomelli
According to the current European Association for the Study of Liver guidelines, transarterial chemoembolization (TACE) is the recommended first-line therapy for patients with intermediate-stage (Barcelona Clinic Liver Cancer-B class) hepatocellular carcinoma (HCC). The efficacy of this therapy is supported by robust evidence; however, there is still a lack of standardization in treatment methodology, and TACE protocols are widely variable. Moreover, TACE can be associated with a number of contraindications...
2017: Journal of Hepatocellular Carcinoma
https://www.readbyqxmd.com/read/28791698/increased-systemic-exposure-and-stronger-cardiovascular-and-metabolic-adverse-reactions-to-fenoterol-in-individuals-with-heritable-oct1-deficiency
#7
Mladen V Tzvetkov, Johannes Matthaei, Sherin Pojar, Frank Faltraco, Sabrina Vogler, Thomas Prukop, Tina Seitz, Jürgen Brockmöller
Fenoterol is widely used anti-asthmatic and tocolytic agent, but high plasma concentrations of fenoterol may lead to severe and even fatal adverse reactions. We studied whether heritable deficiency of the liver organic cation transporter OCT1, a trait observed in 3% of Europeans and White Americans, affects fenoterol plasma concentrations and toxicity. OCT1 transported fenoterol with high affinity. OCT1 inhibition in human hepatocytes reduced fenoterol uptake 3-fold. After administration of 180 µg fenoterol to 39 healthy individuals, the OCT1-deficicient individuals (zero active OCT1 alleles, n=5) showed 1...
August 9, 2017: Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28774412/current-treatment-guidelines-of-chronic-hepatitis-b-the-role-of-nucleos-t-ide-analogues-and-peginterferon
#8
REVIEW
Marc G Ghany
Chronic hepatitis B is prevalent worldwide and is a major contributor to death from cirrhosis and hepatocellular carcinoma. Thus, the goals of therapy are to prevent the development of cirrhosis, hepatocellular carcinoma and liver-related death. Safe and effective therapy is available but complete cure is not yet possible. The decision to treat is complex and must be individualized. Each of the three major liver societies, the American Association for the Study of Liver Diseases (AASLD), the European Association for the Study of the Liver (EASL) and the Asian Pacific Association for the Study of the Liver (APASL) have developed treatment guidelines to provide healthcare professionals guidance on management of chronic HBV infection...
June 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28768846/clinical-phenotype-and-outcome-of-hepatitis-e-virus-associated-neuralgic-amyotrophy
#9
Jeroen J J van Eijk, Harry R Dalton, Paolo Ripellino, Richard G Madden, Catherine Jones, Miriam Fritz, Claudio Gobbi, Giorgia Melli, Emanuela Pasi, Jenny Herrod, Rebecca F Lissmann, Hamad H Ashraf, Mohamed Abdelrahim, Omar A B A L Masri, Montserrat Fraga, David Benninger, Thierry Kuntzer, Vincent Aubert, Roland Sahli, Darius Moradpour, Hélène Blasco-Perrin, Shahram Attarian, Rene Gérolami, Philippe Colson, Maria T Giordani, Johannes Hartl, Sven Pischke, Nan X Lin, Brendan N Mclean, Richard P Bendall, Marcus Panning, Jean-Marie Peron, Nassim Kamar, Jacques Izopet, Bart C Jacobs, Nens van Alfen, Baziel G M van Engelen
OBJECTIVE: To determine the clinical phenotype and outcome in hepatitis E virus-associated neuralgic amyotrophy (HEV-NA). METHODS: Cases of NA were identified in 11 centers from 7 European countries, with retrospective analysis of demographics, clinical/laboratory findings, and treatment and outcome. Cases of HEV-NA were compared with NA cases without evidence of HEV infection. RESULTS: Fifty-seven cases of HEV-NA and 61 NA cases without HEV were studied...
August 2, 2017: Neurology
https://www.readbyqxmd.com/read/28768577/microplastics-in-livers-of-european-anchovies-engraulis-encrasicolus-l
#10
France Collard, Bernard Gilbert, Philippe Compère, Gauthier Eppe, Krishna Das, Thierry Jauniaux, Eric Parmentier
Microplastics (MPs) are thought to be ingested by a wide range of marine organisms before being excreted. However, several studies in marine organisms from different taxa have shown that MPs and nanoplastics could be translocated in other organs. In this study, we investigated the presence of MPs in the livers of commercial zooplanktivorous fishes collected in the field. The study focuses mainly on the European anchovy Engraulis encrasicolus but concerns also the European pilchard Sardina pilchardus and the Atlantic herring Clupea harengus...
July 30, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28763857/-interpretations-of-easl-2017-clinical-practice-guidelines-on-the-management-of-hepatitis-b-virus-infection
#11
P Hu, H Ren
The European Association for the Study of the Liver recently released the updated Clinical Practice Guidelines on the management of hepatitis B virus infection at the International Liver Congress(TM) 2017 in Amsterdam. The latest clinical practice guideline integrated the latest scientific advances on diagnosis and therapy of hepatitis B, thereby providing optimize the management of patients with either acute or chronic HBV. The latest clinical practice guideline includes new definitions of disease phases, expanded indications for initiating treatment, prevention of mother-to-child transmission, new stopping rules for antiviral therapy...
June 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/28762681/-novel-antiviral-agents-for-the-treatment-of-hcv-among-renal-transplant-recipients
#12
REVIEW
Fabrizio Fabrizi, Francesca M Donato, Piergiorgio Messa
The frequency of hepatitis C virus infection remains high in renal transplant recipients and plays a detrimental role on survival in this population. According to the latest evidence, the adjusted relative risk of mortality and graft loss for anti-HCV seropositive versus anti-HCV negative renal transplant recipients was 1.85 with a 95% confidence interval (CI) of 1.49 ; 2.31 (P < 0.0001) and 1.76 (95% CI, 1.46 ; 2.11) (P < 0.0001), respectively. Interferon-based regimens have been recommended for the treatment of hepatitis C after renal transplantation only in selected circumstances because of an increased risk of acute rejection due to the immuno-stimulatory properties of interferon...
August 1, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://www.readbyqxmd.com/read/28756850/biomarker-responses-of-cu-induced-toxicity-in-european-seabass-dicentrarchus-labrax-assessing-oxidative-stress-and-histopathological-alterations
#13
M Díaz-de-Alba, A Canalejo Raya, M D Granado-Castro, M Oliva Ramírez, B El Mai, F Córdoba García, M Troyano-Montoro, E Espada-Bellido, R Torronteras Santiago, M D Galindo-Riaño
A comprehensive approach to chemical accumulation and biological effects of short-term Cu exposure in juveniles of European seabass (Dicentrarchus labrax) has been achieved. Fish were exposed to 0.01-10mgL(-1) nominal Cu concentrations for 24-96h. Metal concentrations in water and gills, liver, muscle and brain tissues were studied along with oxidative stress biomarkers (superoxide dismutase, catalase, glutathione peroxidase, lipid peroxidation). Induction of oxidative damage was observed in all the organs with differential antioxidant responses; gills appearing as the most sensitive from low environmentally water Cu concentrations as 0...
July 27, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28741298/ifnl4-rs368234815-tt-%C3%AE-g-variant-is-associated-with-liver-damage-in-patients-with-non-alcoholic-fatty-liver-disease
#14
Salvatore Petta, Luca Valenti, Antonino Tuttolomondo, Paola Dongiovanni, Rosaria Maria Pipitone, Calogero Cammà, Daniela Cabibi, Vito Di Marco, Anna Ludovica Fracanzani, Sara Badiali, Valerio Nobili, Silvia Fargion, Stefania Grimaudo, Antonio Craxì
BACKGROUND AND AIMS: The IFNL3/4 locus influencing innate immunity regulation has been associated with the severity of hepatitis and fibrosis progression during chronic hepatitis C infection, while contrasting results were reported in NAFLD. In this study, we examined whether rs12979860 and the linked causal rs368234815 variant encoding for the alternative IFNL4 protein variant are associated with liver fibrosis and damage in a large multicenter cohort of patients at risk of NASH. To clarify the mechanism, we also evaluated the impact on interferon-stimulated gene (ISG) hepatic expression in a subset of patients...
July 24, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28731371/determinants-of-infection-outcome-in-hcv-genotype-4
#15
Rania A Zayed, Dalia Omran, Abeer A Zayed, Lobna O Elmessery
Hepatitis C virus (HCV) infection represents a worldwide health problem and has been for long an attractive point of research due to diversity among different genotypes regarding unique geographical distribution and diverse treatment outcome. HCV is considered a major cause of chronic liver disease and cirrhosis, which leads to liver failure and hepatocellular carcinoma requiring liver transplantation. Of the HCV genotypes identified, HCV genotype 4 (HCV-4) is the least studied. HCV-4 is responsible for ∼10% of HCV infections and is common in the Middle East and Africa; recently it is increasingly prevalent in European Countries...
July 21, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28729070/abc-transporters-in-the-liver-fluke-opisthorchis-felineus
#16
Viatcheslav A Mordvinov, Nikita I Ershov, Darya S Pirozhkova, Yuri V Pakharukov, Maria Y Pakharukova
ATP-binding cassette transporters (ABC transporters) are essential components of normal cellular physiological machinery in all eukaryotic and prokaryotic species, including parasites. Some ABC transporters, e.g., P-glycoproteins, are involved in the efflux of toxins and xenobiotics from the cell. At present, nothing is known about ABC transporter genes in epidemiologically important liver flukes from the Opisthorchiidae family, including European liver fluke Opisthorchis felineus. Opisthorchiasis caused by O...
July 17, 2017: Molecular and Biochemical Parasitology
https://www.readbyqxmd.com/read/28722762/rapid-depuration-of-mercury-in-songbirds-accelerated-by-feather-molt
#17
Margaret Whitney, Daniel Cristol
Mercury (Hg) is a ubiquitous environmental contaminant that affects avian reproduction and condition, in both aquatic and terrestrial species. Because Hg binds strongly to the keratin of growing feathers, molt is an important avenue for Hg elimination. We investigated the rate of depuration of Hg from songbird blood and organs (brain, kidney, liver, muscle) as a function of molt. We exposed 2 species of captive songbirds, European starling (Sturnus vulgaris) and zebra finch (Taeniopygia guttata), to environmentally relevant dietary Hg (1...
July 19, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28717870/laparoscopic-liver-resections-for-hepatocellular-carcinoma-can-we-extend-the-surgical-indication-in-cirrhotic-patients
#18
Federica Cipriani, Corrado Fantini, Francesca Ratti, Roberto Lauro, Hadrien Tranchart, Mark Halls, Vincenzo Scuderi, Leonid Barkhatov, Bjorn Edwin, Roberto I Troisi, Ibrahim Dagher, Paolo Reggiani, Giulio Belli, Luca Aldrighetti, Mohammad Abu Hilal
BACKGROUND: Evidence on the value of laparoscopic liver resections (LLR) for hepatocellular carcinoma (HCC) and severe cirrhosis is still lacking. The aim of this study is to assess surgical and oncological outcomes of LLR in cirrhotic HCC patients. METHODS: The analysis included 403 LLR for HCC from seven European centres. 333 cirrhotic and 70 non-cirrhotic patients were compared. A matched comparison was performed between 100 Child-Pugh A and 25 Child-Pugh B patients...
July 17, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28717391/transcriptional-mechanisms-underlying-life-history-responses-to-climate-change-in-the-three-spined-stickleback
#19
Sin-Yeon Kim, Maria M Costa, Anna Esteve-Codina, Alberto Velando
Phenotypic plasticity, the ability of an organism to express different phenotypes depending on the environment, provides an important mechanism by which an animal population can persist under rapid climate change. We experimentally tested both life-history and transcriptional responses of an ecological model species, the three-spined stickleback, to warm acclimation at the southern edge of its European range. We explored cross-environment genetic correlations of key life-history traits in male sticklebacks exposed to long-term temperature changes to examine whether the plasticity pattern was variable among genotypes by using a character-state approach...
August 2017: Evolutionary Applications
https://www.readbyqxmd.com/read/28708518/ultrasonography-to-assist-with-timing-of-spawning-in-european-eel
#20
Pauline Jéhannet, Leon T N Heinsbroek, Arjan P Palstra
Ovulation in the European eel can be induced by injection of DHP (17α,20β-dihydroxy-4-pregnen-3-one). The timing of injection is based on the developmental stage of the oocytes. The oocyte stage is determined by invasive biopsy or through external indicators of the oocyte hydration response: body weight index (BWI) and body girth index (BGI). However, in European eel, BWI and BGI are inaccurate indicators because the individual hydration response is highly variable. The aim of this study was to identify indicators of oocyte maturation non-invasively by applying ultrasonography...
June 10, 2017: Theriogenology
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