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Cytokine adjuvant

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https://www.readbyqxmd.com/read/28725225/antiviral-functions-of-human-immunodeficiency-virus-type-1-hiv-1-specific-igg-antibodies-effects-of-antiretroviral-therapy-and-implications-for-therapeutic-hiv-1-vaccine-design
#1
REVIEW
Martyn A French, M Christian Tjiam, Laila N Abudulai, Sonia Fernandez
Contemporary antiretroviral therapy (ART) is effective and tolerable for long periods of time but cannot eradicate human immunodeficiency virus type 1 (HIV-1) infection by either elimination of viral reservoirs or enhancement of HIV-1-specific immune responses. Boosting "protective" HIV-1-specific immune responses by active or passive immunization will therefore be necessary to control or eradicate HIV-1 infection and is currently the topic of intense investigation. Recently reported studies conducted in HIV patients and non-human primate (NHP) models of HIV-1 infection suggest that HIV-1-specific IgG antibody responses may contribute to the control of HIV-1 infection...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28719308/a-recombinant-47-kda-outer-membrane-protein-induces-an-immune-response-against-orientia-tsutsugamushi-strain-boryong
#2
Sangho Choi, Hang Jin Jeong, Kyu-Jam Hwang, Byoungchul Gill, Young Ran Ju, Yeong Seon Lee, Jeongmin Lee
We investigated the 47-kDa outer membrane protein (OMP), which is a periplasmic serine protease and an antigenic major surface protein of Orientia tsutsugamushi, as a vaccine candidate. We developed a conventional subunit vaccine expressing recombinant 47-kDa OMP (rec47) and a DNA vaccine (p47). In mouse immunization experiments, intranasal immunization with rec47 alone or with rec47 plus heat-labile enterotoxin B subunit from Escherichia coli or plus cholera toxin (CT) as adjuvants induced a higher amount of rec47-specific antibodies than intramuscular immunization with p47 alone or with p47 plus pBOOST2-samIRF7/3 (pB) as adjuvant...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28711032/influence-of-the-number-and-interval-of-treatment-cycles-on-cytokine-induced-killer-cells-and-their-adjuvant-therapeutic-effects-in-advanced-non-small-cell-lung-cancer-nsclc
#3
Yuanlong Gu, Huimin Lv, Juan Zhao, Qi Li, Guannan Mu, Jiade Li, Jiazi Wuyang, Ge Lou, Ruitao Wang, Yanqiao Zhang, Xiaoyi Huang
OBJECTIVE: Cytokine-induced killer (CIK) cells have important therapeutic effects in adoptive cell transfer (ACT) for the treatment of various malignancies. In this study, we focused on in vitro expansion of CIK cells and their clinical efficacy in combination with chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC). METHODS: A total of 64 patients with NSCLC (enrolled from 2011 to 2012), including 32 patients who received chemotherapy alone or with sequential radiotherapy (conventional treatment, control group) and 32 patients who received conventional treatment and sequential CIK infusion (study group), were retrospectively analyzed...
July 12, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28710417/talen-based-hpv-e7-editing-triggers-necrotic-cell-death-in-cervical-cancer-cells
#4
Sumitra Shankar, Deepti Prasad, Rahul Sanawar, Ani V Das, M Radhakrishna Pillai
Human Papillomavirus E7 and E6 oncoproteins have been considered as suitable candidate anti-viral targets since they cause malignant conversion in cervical cancers. Transcription Activator-Like Effector Nucleases (TALENs) are recent editing tools to knockout genes by inducing double stranded breaks at specific sites in the genome. In here, we have designed specific TALENs to target E7 and analyzed their efficiency in inducing cell death in cervical cancer cells. We found that designed TALENs could yield about 10-12% editing activity as observed from T7E1 and nuclease resistance assays...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28708978/methotrexate-combined-with-cyclophosphamide-attenuates-murine-collagen-induced-arthritis-by-modulating-the-expression-level-of-breg-and-dcs
#5
Jinnan Fan, Jing Luo, Caiping Yan, Runxi Hao, Xiangcong Zhao, Ruihuan Jia, Jiaojiao He, Dan Xu, Miao Miao, Xiaofeng Li
To explore the mechanism of methotrexate (MTX) and its combination with cyclophosphamide (CTX) in collagen-induced arthritis (CIA), we investigated the levels of several immune cells and cytokines in mice with different treatments. CIA was induced in DBA/1 mice at the age of 7 weeks by primary immunization with 100μl emulsion containing 2mg/ml bovine type II collagen which was mixed with complete Freund's adjuvant (CFA). The booster immunization was performed with 50-100μl emulsion containing 2mg/ml bovine type II collagen (CII) mixed with incomplete Freund's adjuvant (IFA)...
July 11, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28704679/ph-sensitive-polymer-modified-liposome-based-immunity-inducing-system-effects-of-inclusion-of-cationic-lipid-and-cpg-dna
#6
Yuta Yoshizaki, Eiji Yuba, Naoki Sakaguchi, Kazunori Koiwai, Atsushi Harada, Kenji Kono
Efficient vaccine carriers for cancer immunotherapy require two functions: antigen delivery to dendritic cells (DCs) and the activation of DCs, a so-called adjuvant effect. We previously reported antigen delivery system using liposomes modified with pH-sensitive polymers, such as 3-methylglutarylated hyperbranched poly(glycidol) (MGlu-HPG), for the induction of antigen-specific immune responses. We reported that inclusion of cationic lipids to MGlu-HPG-modified liposomes activates DCs and enhances antitumor effects...
July 3, 2017: Biomaterials
https://www.readbyqxmd.com/read/28694777/pharmacological-properties-and-molecular-mechanisms-of-thymol-prospects-for-its-therapeutic-potential-and-pharmaceutical-development
#7
REVIEW
Mohamed Fizur Nagoor Meeran, Hayate Javed, Hasan Al Taee, Sheikh Azimullah, Shreesh K Ojha
Thymol, chemically known as 2-isopropyl-5-methylphenol is a colorless crystalline monoterpene phenol. It is one of the most important dietary constituents in thyme species. For centuries, it has been used in traditional medicine and has been shown to possess various pharmacological properties including antioxidant, free radical scavenging, anti-inflammatory, analgesic, antispasmodic, antibacterial, antifungal, antiseptic and antitumor activities. The present article presents a detailed review of the scientific literature which reveals the pharmacological properties of thymol and its multiple therapeutic actions against various cardiovascular, neurological, rheumatological, gastrointestinal, metabolic and malignant diseases at both biochemical and molecular levels...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28694747/evaluation-of-central-and-peripheral-effects-of-doxepin-on-acetic-acid-induced-colitis-in-rat-and-the-involved-mechanisms
#8
Mohsen Zabihi, Valiollah Hajhashemi, Ardeshir Talebi, Mohsen Minaiyan
Anti-colitis effect of antidepressants has been demonstrated recently. Doxepin, a tricyclic antidepressant drug (TCA), with potent H1, H2, alpha1 adrenergic and muscarinic receptor blocking effects could be a good candidate for investigation for its anti-colitis activity. Moreover high prevalence of depression in patients who suffer from IBD (inflammatory bowel disease), defends this idea that adjuvant therapy with an antidepressant drug which has anti-inflammatory effect, may exert favorable effects in the control of the disease...
2017: EXCLI journal
https://www.readbyqxmd.com/read/28692940/betulinic-acid-and-fluvastatin-exhibits-synergistic-effect-on-toll-like-receptor-4-mediated-anti-atherogenic-mechanism-in-type-ii-collagen-induced-arthritis
#9
Limi Elizabeth Mathew, Vrinda Rajagopal, Helen A
Cardiovascular disease (CVD) is a major problem during rheumatoid arthritis which leads to morbidity and mortality in arthritic patients. So the present study emphasizes combinatorial effect of Betulinic acid, a triterpenoid and fluvastatin, an HMG CoA reductase inhibitor on atherogenesis during arthritis. Arthritis was induced by bovine type II collagen dissolved in 0.01M acetic acid at a concentration of 4mg/mL and emulsified in equal volume of incomplete Freund's adjuvant. Betulinic acid (2mg/kg) and fluvastatin (5mg/kg) alone and in combination was administered orally from day 14 to 60...
July 7, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28688946/anti-arthritic-effect-of-pilose-antler-peptide-on-adjuvant-induced-rheumatoid-arthritis-in-rats
#10
Zuo Ting, Long Hongyan, Wu Suling, Huang Luqi
The anti-inflammatory property of pilose antler peptide (PAP) aroused our interest. To investigate the effect of PAP on Freund's complete adjuvant (FCA)-induced arthritis in rats was the aim of this study. Adjuvant-induced arthritis (AA) was induced by the administration of 0.1ml FCA in the surface of hind paw. Diclofenac sodium (DS) and Fasudil were administered as positive controls. Down-regulation of cytokines including interleukin-6 (IL-6), interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α), revealed anti-inflammatory effect of PAP, which was consisted with pathological conditions of rat paws...
July 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28687406/comparative-efficacy-and-toxicity-of-two-vaccine-candidates-against-sporothrix-schenckii-using-either-montanide%C3%A2-pet-gel-a-or-aluminum-hydroxide-adjuvants-in-mice
#11
Deivys Leandro Portuondo, Alexander Batista-Duharte, Lucas Souza Ferreira, Cleverton Roberto de Andrade, Camila Quinello, Damiana Téllez-Martínez, Maria Luiza de Aguiar Loesch, Iracilda Zeppone Carlos
Sporotrichosis is an important zoonosis in Brazil and the most frequent subcutaneous mycosis in Latin America, caused by different Sporothrix species. Currently, there is no effective vaccine available to prevent this disease. In this study, the efficacy and toxicity of the adjuvant Montanide™ Pet Gel A (PGA) formulated with S. schenckii cell wall proteins (ssCWP) was evaluated and compared with that of aluminum hydroxide (AH). Balb/c mice received two subcutaneous doses (1st and 14th days) of either the unadjuvanted or adjuvanted vaccine candidates...
July 4, 2017: Vaccine
https://www.readbyqxmd.com/read/28687020/chemotherapy-administration-to-breast-cancer-patients-affects-extracellular-vesicles-thrombogenicity-and-function
#12
Anat Aharon, Anni Sabbah, Shahar Ben-Shaul, Hila Berkovich, David Loven, Benjamin Brenner, Gil Bar-Sela
Breast cancer (BC) is the most prevalent type of malignancy in women. Extracellular vesicles (EVs) are subcellular membrane blebs that include exosomes and microparticles. STUDY AIMS: To elucidate the effects of chemotherapy administration on BC patients' EVs characteristics and their effects on endothelial cells (EC) functions. METHODS: EVs were isolated from the blood samples of 54 BC patients treated by chemotherapy (25 neo-adjuvant, 29 adjuvant) and from 20 healthy women (control group)...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28678171/the-immune-adjuvant-effects-of-flounder-paralichthys-olivaceus-interleukin-6-on-e-tarda-subunit-vaccine-ompv
#13
Ming Guo, Xiaoqian Tang, Xiuzhen Sheng, Jing Xing, Wenbin Zhan
Interleukin-6 (IL-6) as a pleiotropic cytokine was widely used as an effective adjuvant for vaccines in mammals. In this study, the immune adjuvant effects of two forms of flounder (Paralichthys olivaceus) IL-6, including recombinant IL-6 (rIL-6) and pcDNA3.1-IL-6 (pcIL-6), were evaluated and comparatively analyzed on E. tarda subunit vaccine recombinant outer membrane protein V (rOmpV). The results showed that the relative percent survivals of flounder vaccinated with rOmpV plus rIL-6 or pcIL-6 were significantly higher than that in the two control groups, rOmpV plus recombinant 6× histidine-tag (rHis) or empty expression vector pcDNA3...
July 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28673008/sesamol-attenuates-oxidative-stress-apoptosis-and-inflammation-in-focal-cerebral-ischemia-reperfusion-injury
#14
Xiu-Juan Gao, Guan-Nan Xie, Lei Liu, Zhi-Jian Fu, Zong-Wang Zhang, Liang-Zhu Teng
The aim of the present study was to evaluate the therapeutic potential of sesamol treatment on focal ischemia/reperfusion (I/R) injury in the rat brain. The results demonstrated that pretreatment with sesamol seven days prior to focal cerebral I/R injury had significant positive effects, including improvements in neurological deficits (P<0.05), and a reduction in malondialdehyde content and elevation of antioxidant levels (superoxide dismutase, glutathione and glutatione peroxidase; both P<0.05). Furthermore, levels of B cell lymphoma-2 (Bcl-2)-associated X protein and caspase-3 were significantly downregulated, whereas the level of Bcl-2 was effectively increased...
July 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28669593/pathogen-mimicking-vaccine-delivery-system-designed-with-a-bioactive-polymer-inulin-acetate-for-robust-humoral-and-cellular-immune-responses
#15
Hemachand Tummala, Sunny Kumar, Siddharth S Kesharwani, Bhimanna Kuppast, Mohammed Ali Bakkari
New and improved vaccines are needed against challenging diseases such as malaria, tuberculosis, Ebola, influenza, AIDS, and cancer. The majority of existing vaccine adjuvants lack the ability to significantly stimulate the cellular immune response, which is required to prevent the aforementioned diseases. This study designed a novel particulate based pathogen-mimicking vaccine delivery system (PMVDS) to target antigen-presenting-cells (APCs) such as dendritic cells. The uniqueness of PMVDS is that the polymer used to prepare the delivery system, Inulin Acetate (InAc), activates the innate immune system...
June 29, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28668397/interleukin-6-c-ebp-%C3%AE-and-ppar-%C3%AE-expression-correlates-with-intramuscular-liposarcoma-growth-in-mice-the-impact-of-voluntary-physical-activity-levels
#16
Mohamad Assi, Moussa Kenawi, Mickaël Ropars, Amélie Rébillard
IL-6 is an axial cytokine overexpressed in cancer to promote growth and increase resistance to anti-cancer therapies. As the application of IL-6-targeting therapies are still limited, alternative non-aggressive and adjuvant approaches, like physical activity (PA) could be useful to reverse IL-6 effects. To get more insights into liposarcoma (LS) pathophysiology, we investigated potential molecular links between IL-6 and LS growth and we tested the impact of PA on such mechanism in an orthotopic model of intramuscular LS...
June 28, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28666598/a-meta-analysis-of-n-3-polyunsaturated-fatty-acids-effects-on-circulating-acute-phase-protein-and-cytokines-in-gastric-cancer
#17
Michel C Mocellin, Ricardo Fernandes, Thayz R Chagas, Erasmo B S M Trindade
BACKGROUND & AIMS: Chronic inflammation is related with cancer and leads to worsening prognosis in cancer patients. n-3 polyunsaturated fatty acids (PUFAs) supplementation has been proposed as adjuvant treatment in cancer due anti-inflammatory properties. In the present meta-analysis, we pooled randomized clinical trials (RCTs) assessing the effects of n-3 PUFAs (from fish oil isolated or added in an immunonutrition formula) on inflammatory markers in gastric cancer. METHODS: A comprehensive literature search was performed in Medline, Scopus, Cochrane library, Science Direct and Web of Science, besides GOOGLE Scholar and a hand searching of reference lists, through July 2016...
May 13, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28665747/analysis-of-immunological-mechanisms-exerted-by-hbsag-hbig-therapeutic-vaccine-combined-with-adefovir-in-chronic-hepatitis-b-patients
#18
Chenliang Zhou, Chaofan Li, Guo-Zhong Gong, Shuang Wang, Ji-Ming Zhang, Dao-Zhen Xu, Li-Min Guo, Hong Ren, Min Xu, Qing Xie, Chen Pan, Jie Xu, Zhongyu Hu, Shuang Geng, Xian Zhou, Xianzheng Wang, Xiaoyu Zhou, Haili Mi, Gan Zhao, Wencong Yu, Yu-Mei Wen, Lihua Huang, Xuan-Yi Wang, Bin Wang
An HBsAg-HBIG therapeutic vaccine (Yeast-derived Immune Complexes, YIC) for chronic hepatitis B (CHB) patients has undergone a series of clinical trials. The HBeAg sero-conversion rate of YIC varied from 21.9% to 14% depending on the immunization protocols from 6 to 12 injections. To analyze the immunological mechanisms exerted by 6 injections of YIC, 44 CHB patients were separately immunized with YIC, alum as adjuvant control or normal saline as blank control, with add on of antiviral drug Adefovir in all groups...
June 30, 2017: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28664762/induced-pluripotent-stem-cell-based-therapy-for-age-related-macular-degeneration
#19
Peter Bracha, Nicholas A Moore, Thomas A Ciulla
In age-related macular degeneration (AMD), stem cells could possibly replace or regenerate disrupted pathologic retinal pigment epithelium (RPE), and produce supportive growth factors and cytokines such as brain-derived neurotrophic factor.  Induced pluripotent stem cells (iPSCs)-derived RPE was first subretinally transplanted in a neovascular AMD patient in 2014. Areas covered: Induced PSCs are derived from the introduction of transcription factors to adult cells under specific cell culture conditions, followed by differentiation into RPE cells...
June 30, 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28662951/cd11a-and-cd49d-enhance-the-detection-of-antigen-specific-t-cells-following-human-vaccination
#20
Allison F Christiaansen, Upasna Gaur Dixit, Rhea N Coler, Anna Marie Beckmann, Steven G Reed, Patricia L Winokur, M Bridget Zimmerman, Steven M Varga, Mary E Wilson
BACKGROUND: Determining the efficacy of human vaccines that induce antigen-specific protective CD4 T cell responses against pathogens can be particularly challenging to evaluate. Surface expression of CD11a and CD49d has been shown to identify antigen-specific CD4 T cells against viral pathogens in mice. We hypothesized that CD11a and CD49d would also serve as markers of human antigen-specific T cells responding to vaccination. METHODS: A phase I vaccine trial enabled us to evaluate a novel gating strategy based on surface expression of CD11a and CD49d as a means of detecting antigen-specific, cytokine producing CD4 and CD8 T cells induced after vaccination of naïve individuals against leishmaniasis...
June 26, 2017: Vaccine
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