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Cytokine adjuvant

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https://www.readbyqxmd.com/read/27920777/physical-interaction-of-t-cells-with-dendritic-cells-is-not-required-for-the-immunomodulatory-effects-of-the-edible-mushroom-agaricus-subrufescens
#1
Ruud H P Wilbers, Lotte B Westerhof, Jan van de Velde, Geert Smant, Debbie R van Raaij, Anton S M Sonnenberg, Jaap Bakker, Arjen Schots
Mushrooms are well known for their immunomodulating capacities. However, little is known about how mushroom-stimulated dendritic cells (DCs) affect T cells. Therefore, we investigated the effect of mushroom compounds derived from seven edible mushroom species on DCs, their fate in DCs, and the effect of the mushroom-stimulated DCs on T cells. Each mushroom species stimulated DCs in a different manner as was revealed from the DC's cytokine response. Assessing DC maturation revealed that only one mushroom species, Agaricus subrufescens, induced complete DC maturation...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27918020/effects-of-ovalbumin-protein-nanoparticle-vaccine-size-and-coating-on-dendritic-cell-processing
#2
Timothy Z Chang, Samantha S Stadmiller, Erika Staskevicius, Julie A Champion
Nanoparticle vaccine delivery platforms are a promising technology for enhancing vaccine immunogenicity. Protein nanoparticles (PNPs), made entirely from antigen, have been shown to induce protective immune responses against influenza. However, the fundamental mechanisms by which PNPs enhance component protein immunogenicity are not understood. Here, we investigate the role of size and coating of model ovalbumin (OVA) PNPs on particle uptake and trafficking, as well as on inflammation and maturation factor expression in dendritic cells (DCs) in vitro...
December 5, 2016: Biomaterials Science
https://www.readbyqxmd.com/read/27917904/glycoprotein-130-is-associated-with-adverse-postoperative-clinical-outcomes-of-patients-with-late-stage-non-metastatic-gastric-cancer
#3
Yifan Cao, Heng Zhang, Hao Liu, Chao Lin, Ruochen Li, Songyang Wu, Hongyong He, He Li, Jiejie Xu
The interaction of glycoprotein 130 (gp130) with the cytokines of Interleukin-6 (IL-6) family has proved to play a crucial part in several cancers. Our current study is designed to discover the clinical prognostic significance of gp130 in non-metastatic gastric cancer. We examined intratumoral gp130 expression in retrospectively enrolled 370 gastric cancer patients who underwent radical gastrectomy with standard D2 lymphadenectomy at Zhongshan Hospital of Fudan University during 2007 and 2008 by immunohistochemical staining...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27908965/inf-%C3%AE-encoding-plasmid-administration-triggers-bone-loss-and-disrupts-bone-marrow-microenvironment
#4
Dimitrios Agas, Guilherme Gusmâo Silva, Fulvio Laus, Andrea Marchigiani, Melania Capitani, Cecilia Vullo, Giuseppe Catone, Giovanna Lavava, Antonio Concetti, Luigi Marchetti, Maria Giovanna Sabbieti
IFN-γ is a pleotropic cytokine produced in the bone microenvironment. Although IFN-γ is known to play a critical role on bone remodeling, its function is not fully elucidated. Consistently, outcomes on the effects of IFN-γ recombinant protein on bone loss are contradictory among reports. In our work we explored, for the first time, the role of IFN-γ encoding plasmid (pIFN-γ) in a mouse model of osteopenia induced by ovariectomy and in the sham-operated counterpart to estimate its effects in skeletal homeostasis...
December 1, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27899275/immunological-consequences-of-immunization-with-tumor-lysate-vaccine-and-propranolol-as-an-adjuvant-a-study-on-cytokine-profiles-in-breast-tumor-microenvironment
#5
Somayeh Ashrafi, Reza Shapouri, Mehdi Mahdavi
In this study, we sought out to study the anti-cancer effects of propranolol (Pro) in combination with tumor lysate vaccine on lymphocyte proliferation activities as well as on IL-2, IL-4, IL-10, IL-12, IL-17 and IFN-γ cytokine concentration in the tumor microenvironment (TME). A tumor model was established in inbred Balb/C mice using transplantation of tumor to the flank of native mice. Tumor-bearing mice were immunized with lysate tumor cells (vaccine), a combination of Pro/Vaccine (Vac). Control groups consisted of tumor-bearing mice receiving only propranolol or PBS three times with one week interval via subcutaneous (s...
November 27, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27899228/the-recombinant-n-terminal-domain-of-spike-proteins-is-a-potential-vaccine-against-middle-east-respiratory-syndrome-coronavirus-mers-cov-infection
#6
Lan Jiaming, Yao Yanfeng, Deng Yao, Hu Yawei, Bao Linlin, Huang Baoying, Yan Jinghua, George F Gao, Qin Chuan, Tan Wenjie
The persistent public health threat of infection with the Middle East respiratory syndrome coronavirus (MERS-CoV) highlights the need for an effective MERS-CoV vaccine. Previous studies have focused mainly on the receptor-binding domain (RBD) on the spike protein of MERS-CoV. Herein, we investigated the immunogenicity and protective potential of the recombinant N-terminal domain (rNTD) of spike proteins as a vaccine candidate. BALB/c mice vaccinated with 5 or 10μg of rNTD protein demonstrated a significant humoral immune response (serum IgG and neutralizing activity)...
November 26, 2016: Vaccine
https://www.readbyqxmd.com/read/27891512/a-de-o-acylated-lipooligosaccharide-based-adjuvant-system-promotes-antibody-and-th1-type-immune-responses-to-h1n1-pandemic-influenza-vaccine-in-mice
#7
Ji In Ryu, Shin Ae Park, Seo Ri Wui, Ara Ko, Ji Eun Han, Jung Ah Choi, Man Ki Song, Kwang Sung Kim, Yang Je Cho, Na Gyong Lee
Vaccine adjuvants are agents that are used to promote immune responses to vaccine antigens and thereby to enhance the protective efficacy of the vaccines. In this study, we investigated the adjuvant activity of CIA06, an adjuvant system that is composed of a toll-like receptor 4 agonist de-O-acylated lipooligosaccharide (dLOS) and aluminum hydroxide, on the H1N1 pandemic influenza vaccine Greenflu-S® in mice. CIA06 significantly enhanced influenza-specific serum IgG, hemagglutination-inhibition, and virus-neutralizing antibody titers, which eliminated vaccine dose-dependency in the antibody response...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27888157/curcumin-use-in-pulmonary-diseases-state-of-the-art-and-future-perspectives
#8
REVIEW
Diana Lelli, Amirhossein Sahebkar, Thomas P Johnston, Claudio Pedone
Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric (Curcuma longa). It has been used for centuries in Ayurveda (Indian traditional medicine) for the treatment of several diseases. Over the last several decades, the therapeutic properties of curcumin have slowly been elucidated. It has been shown that curcumin has pleiotropic effects, regulating transcription factors (e.g., NF-kB), cytokines (e.g., IL6, TNF-alpha), adhesion molecules (e.g., ICAM-1), and enzymes (e.g., MMPs) that play a major role in inflammation and cancerogenesis...
November 22, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27886556/modular-delivery-of-cpg-incorporated-lipid-dna-nanoparticles-for-spleen-dc-activation
#9
Jun-O Jin, Haein Park, Wei Zhang, Jan Willem de Vries, Agnieszka Gruszka, Myung Won Lee, Dae-Ro Ahn, Andreas Herrmann, Minseok Kwak
We introduce a versatile carrier system for in vitro and in vivo immune stimulation based on soft matter DNA nanoparticles (NPs). The incorporation of lipid-modified nucleotides into DNA strands enables the formation of micelles of uniform size. In a single self-assembly step, the micelles can be equipped with immune adjuvant (CpG) motifs and fluorescent probes. The immunological effects of CpG confined at the NP surface were studied in a comprehensive manner in animal experiments. Dose-dependent activation of spleen dendritic cells (DCs) by CpG-conjugated NP was observed, which was accompanied by the pronounced up-regulation of co-stimulatory molecule and cytokine production...
January 2017: Biomaterials
https://www.readbyqxmd.com/read/27881147/p53-predominantly-regulates-il-6-production-and-suppresses-synovial-inflammation-in-fibroblast-like-synoviocytes-and-adjuvant-induced-arthritis
#10
Ting Zhang, Huihua Li, Juan Shi, Sha Li, Muyuan Li, Lei Zhang, Leting Zheng, Dexian Zheng, Fulin Tang, Xuan Zhang, Fengchun Zhang, Xin You
BACKGROUND: Dominant-negative somatic mutations of p53 has been identified in the synovium of patients with rheumatoid arthritis (RA), in which interleukin (IL)-6 has been established as a pivotal inflammatory cytokine. The aim of this study was to clarify the significance of p53 in the longstanding inflammation in RA by modulating IL-6. METHODS: We established adjuvant-induced arthritis (AIA) in Lewis rats and treated them with p53 activator, and then analyzed the histopathology of the synovium and IL-6 expression...
November 24, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27876361/beneficial-effects-of-galectin-9-on-allergen-specific-sublingual-immunotherapy-in-a-dermatophagoides-farinae-induced-mouse-model%C3%A2-of-chronic-asthma
#11
Masaki Ikeda, Shigeki Katoh, Hiroki Shimizu, Akira Hasegawa, Katsuyo Ohashi-Doi, Mikio Oka
BACKGROUND: Allergen-specific sublingual immunotherapy is a potential disease-modifying treatment for allergic asthma. Galectin-9 (Gal-9), a β-galactoside-binding protein with various biologic effects, acts as an immunomodulator in excessive immunologic reactions by expanding regulatory T cells (Treg) and enhancing transforming growth factor (TGF)-β signaling. We investigated the efficacy of sublingually administered Gal-9 as an adjuvant to a specific allergen in a Dermatophagoides farinae (Df)-induced mouse model of chronic asthma...
November 19, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27876114/modified-platelet-rich-plasma-with-transforming-growth-factor-%C3%AE-1-neutralization-antibody-injection-may-reduce-recurrence-rate-of-urethral-stricture
#12
Murat Gul
Urethral stricture is one of the most bothersome urologic disease among urologists and has a substantial impact on quality of life and healthcare costs. Although it can be cured with internal urethrotomy easily, post-surgery stricture recurrence is challenging. Several adjuvant therapies have been used in conjunction with internal urethrotomy but none of them are used routinely because the pathophysiology of the disease is still obscure. Fibrosis is the most accused hypothesis for the action. Platelet-rich plasma (PRP) is an autologous blood product containing a high concentration of platelets that is being used for a very wide range of clinical healing applications...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27872951/immunogenicity-and-efficacy-of-a-rationally-designed-vaccine-against-vascular-endothelial-growth-factor-in-mouse-solid-tumor-models
#13
Aizhang Xu, Li Zhang, Yangyang Chen, Zhibing Lin, Rongxiu Li
Vascular endothelial growth factor (VEGF) plays an important role in the progression of various cancers. The VEGF-specific antibody bevacizumab combined with chemotherapy was shown to significantly improve progression-free survival in certain cancers. However, repeated administration is necessary for effective suppression of VEGF, thereby making the therapy expensive and cumbersome. Thus, it is urgent to develop alternative reagents such as VEGF vaccines. Here we report that DTT-VEGF, a VEGF-based antigen consisting of the receptor-binding domain of VEGF and diphtheria toxin T domain (DTT), not only stimulated neutralizing antibody response, but also induced type 1 immune response as well as anti-tumor cytotoxic T lymphocytes in mice when administered with aluminum hydroxide adjuvant...
November 21, 2016: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/27872694/long-term-treatment-by-vitamin-b1-and-reduction-of-serum-proinflammatory-cytokines-hyperalgesia-and-paw-edema-in-adjuvant-induced-arthritis
#14
Jalal Zaringhalam, Akhtar Akbari, Alireza Zali, Homa Manaheji, Vida Nazemian, Mahdi Shadnoush, Somayeh Ezzatpanah
INTRODUCTION: Immune system is involved in the etiology and pathophysiology of inflammation and vitamins are important sources of substances inducing nonspecific immunomodulatory effects. Given the proinflammatory role of cytokines in the inflammation and pain induction, this study aimed to assess the effects of long-term administration of vitamin B1 on the proinflammatory cytokines, edema, and hyperalgesia during the acute and chronic phases of adjuvant-induced arthritis. METHODS: On the first day of study, inflammation was induced by intraplantar injection of complete Freund's adjuvant (CFA) in the hindpaws of rats...
October 2016: Basic and Clinical Neuroscience
https://www.readbyqxmd.com/read/27867030/gemcitabine-treatment-enhanced-the-anti-tumor-effect-of-cytokine-induced-killer-cells-by-depletion-of-cd4-cd25-bri-regulatory-t-cells
#15
Peng Zhao, Danni Zhu, Zhen Zhang, Bin Han, Daiqing Gao, Xiaofang Wei, Xihe Xie, Changyou Li, Weihong Sun, Qingqing Wang, Qingming Guo
Cytokine induced killer (CIK) cells have a powerful tumor cells killing activity both in vitro and in vivo and transfusion of these cells have become an adjuvant treatment for tumors. CIK cells are induced and amplified from peripheral blood mononuclear cells (PBMCs) with multiple cytokines. As CD4(+)CD25(bri) regulatory T cells can be also induced by high dose of interleukin 2 (IL-2) which is used for CIK cells amplification in the CIK cell culture system, the anti-tumor activity of CIK cells was suppressed to some extent...
November 17, 2016: Immunology Letters
https://www.readbyqxmd.com/read/27863662/surface-assembled-poly-i-c-on-pegylated-plga-microspheres-as-vaccine-adjuvant-apc-activation-and-bystander-cell-stimulation
#16
Annina M Hafner, Blaise Corthésy, Marcus Textor, Hans P Merkle
Biodegradable poly(lactic-co-glycolic acid) (PLGA) microspheres are potential vehicles to deliver antigens for vaccination. Because they lack the full capacity to activate professional antigen presenting cells (APCs), combination with an immunostimulatory adjuvant may be considered. A candidate is the synthetic TLR3 ligand polyriboinosinic acid-polyribocytidylic acid, poly(I:C), which drives cell-mediated immunity. However, poly(I:C) has also been linked to the pathogenesis of autoimmunity, as affected by widespread stimulation of non-hematopoietic bystander cells...
November 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27859049/lps-primed-heterotolerant-dendritic-cells-suppress-experimental-autoimmune-uveoretintitis-by-multiple-mechanisms
#17
Izabela P Klaska, Elizabeth Muckersie, Cristina Martin-Granados, Maria Christofi, John V Forrester
Exposure of bone marrow derived dendritic cells (BMDC) to high dose ultrapure lipopolysaccharide for 24 hours (h) (LPS-primed BMDC) enhances their potency in preventing inter-photoreceptor retinoid binding protein (IRBP): complete Freund's adjuvant (CFA)-induced experimental autoimmune uveoretinitis (EAU). LPS-primed BMDC are refractory to further exposure to LPS (= endotoxin tolerance, ET), evidenced here by decreased phosphorylation of TANK-binding kinase 1 (TBK1), interferon regulatory factor 3 (IRF3), c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (p38 MAPK) as well as impaired nuclear translocation of nuclear factor κB (NF-κB) and IRF3, resulting in reduced tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, IL-12 and interferon beta (IFN-β) secretion...
November 15, 2016: Immunology
https://www.readbyqxmd.com/read/27856228/mesenchymal-stromal-cell-secretomes-are-modulated-by-suspension-time-delivery-vehicle-passage-through-catheter-and-exposure-to-adjuvants
#18
Kaushik Parsha, Osman Mir, Nikunj Satani, Bing Yang, Waldo Guerrero, Zhuyong Mei, Chunyan Cai, Peng R Chen, Adrian Gee, Patrick J Hanley, Jaroslaw Aronowski, Sean I Savitz
BACKGROUND AIMS: Extensive animal data indicate that mesenchymal stromal cells (MSCs) improve outcome in stroke models. Intra-arterial (IA) injection is a promising route of delivery for MSCs. Therapeutic effect of MSCs in stroke is likely based on the broad repertoire of secreted trophic and immunomodulatory cytokines produced by MSCs. We determined the differential effects of exposing MSCs to different types of clinically relevant vehicles, and/or different additives and passage through a catheter relevant to IA injections...
November 14, 2016: Cytotherapy
https://www.readbyqxmd.com/read/27855374/inflammatory-properties-and-adjuvant-potential-of-synthetic-glycolipids-homologous-to-mycolate-esters-of-the-cell-wall-of-mycobacterium-tuberculosis
#19
Hermann Giresse Tima, Juma''a Raheem Al Dulayymi, Olivier Denis, Pauline Lehebel, Klarah Sherzad Baols, Mohsin Omar Mohammed, Laurent L'Homme, Mohaned Mohammed Sahb, Georges Potemberg, Sylvie Legrand, Roland Lang, Rudi Beyaert, Jacques Piette, Mark Stephen Baird, Kris Huygen, Marta Romano
The cell wall of mycobacteria is characterised by glycolipids composed of different classes of mycolic acids (MAs; alpha-, keto-, and methoxy-) and sugars (trehalose, glucose, and arabinose). Studies using mutant Mtb strains have shown that the structure of MAs influences the inflammatory potential of these glycolipids. As mutant Mtb strains possess a complex mixture of glycolipids, we analysed the inflammatory potential of single classes of mycolate esters of the Mtb cell wall using 38 different synthetic analogues...
November 18, 2016: Journal of Innate Immunity
https://www.readbyqxmd.com/read/27846891/cytokine-and-chemokine-alterations-in-tissue-csf-and-plasma-in-early-presymptomatic-phase-of-experimental-allergic-encephalomyelitis-eae-in-a-rat-model-of-multiple-sclerosis
#20
Nozha Borjini, Mercedes Fernández, Luciana Giardino, Laura Calzà
BACKGROUND: Experimental allergic encephalomyelitis (EAE) is the most commonly used experimental animal model for human multiple sclerosis (MS) that has been used so far to study the acute and remission-relapsing phases of the disease. Despite the vast literature on neuroinflammation onset and progression in EAE, important questions are still open regarding in particular the early asymptomatic phase between immunization and clinical onset. METHODS: In this study, we performed a time-course investigation of neuroinflammation and demyelination biomarkers in the spinal cord (SC), cerebrospinal fluid (CSF), and blood in EAE induced in dark agouti (DA) female rats compared to the controls and adjuvant-injected rats, using high-throughput technologies for gene expression and protein assays and focusing on the time-course between immunization, clinical onset (1, 5, 8 days post-immunization (DPI)), and progression (11 and 18 DPI)...
November 15, 2016: Journal of Neuroinflammation
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