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Cytokine adjuvant

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https://www.readbyqxmd.com/read/29241581/iron-induced-chelation-alleviates-the-potential-allergenicity-of-ovotransferrin-in-a-balb-c-mouse-model
#1
Ping Tong, Lin Gao, Jinyan Gao, Xin Li, Zhihua Wu, Anshu Yang, Hongbing Chen
Ovotransferrin (OVT) is one of the main egg allergens with 2 iron-binding sites. Several studies have demonstrated that iron-chelation decreased the allergenicity of milk allergen and birch pollen allergens. Therefore, we hypothesized that iron-chelation could also reduce the allergenicity of OVT. Apo-OVT (iron-free OVT, the natural state in egg white) and Holo-OVT (iron-chelated OVT) were prepared, and the allergenicity of them were assessed and compared using a BALB/c mouse model as well as dendritic cells (DCs) based on antigen uptake...
November 2017: Nutrition Research
https://www.readbyqxmd.com/read/29238384/antiarthritic-activity-of-qi-wu-rheumatism-granule-a-chinese-herbal-compound-on-complete-freund-s-adjuvant-induced-arthritis-in-rats
#2
Qi Xu, Yong Zhou, Rong Zhang, Zhan Sun, Lu-Feng Cheng
Objective: The aim was to study the therapeutic effects and mechanisms of QWRG on adjuvant-induced RA in rats. Methods: The RA rat models were manipulated and subsequently divided into five experimental groups: AIA, DEX, and QWRG groups. The paw volume, body weight, arthritic score, and mechanical nociceptive threshold were assessed. The serum levels of the RF, MDA, ALP, AST, ALT, IL-1β, IL-2, IL-16, and TNF-α were measured. The proliferative capacity of lymphocytes was evaluated, and the synovial tissue was histopathologically examined...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234720/radiation-induced-circumscribed-superficial-morphea-after-brachytherapy-for-endometrial-adenocarcinoma
#3
Apoorva Trivedi, Corey M DeWitt, Laura McGevna
Radiation-induced morphea (RIM) is a rare and underrecognized complication of radiation therapy that most commonly occurs in women after treatment for breast cancer. Although not fully understood, RIM is hypothesized to arise from an increase in cytokines that stimulate collagen production and extracellular matrix formation. Most documented cases of RIM occur 1 year after radiation therapy and are localized to areas that were treated for breast cancer. We report on a case of a female patient with stage IB endometrial adenocarcinoma who was treated with 24 Gray of adjuvant brachytherapy...
December 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29231166/effect-of-polyvalent-immunoglobulins-on%C3%A2-the%C3%A2-cytokine-cascade-in-monocytes-from%C3%A2-colorectal-cancer-patients-basis-for-a%C3%A2-new-adjuvant-therapy%C3%A2
#4
Martin Gasser, Reinhard Lissner, Ana-Maria Waaga-Gasser
No abstract text is available yet for this article.
December 12, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29230639/conserved-peptides-enhance-immune-efficiency-of-inactive-vaccines-against-emerging-avian-influenza-viruses-in-chicken
#5
Jin Xiao, Lei Zhang, Zhenbao Wang, Wangzhen Xiang, Ping Lu, Yingze Zhao, Min Han, Airong Ma, Peng Qi, Ming Wang, George F Gao, William J Liu
Avian influenza viruses (AIVs) such as H5N1 and H7N9 are a great threat to poultry economics and public health. Vaccination can effectively inhibit the spread of AIV in poultry, which is also a viable strategy for controlling virus transmission from poultry to human. Adjuvants that are commonly used in current inactivated vaccines to provide stronger anti-AIV immune responses are often limited in their capacity to quantitatively induce both humoral and cellular immune responses. Herein, we assessed the levels of immune responses generated by a vaccine formulation comprising inactivated H5N1 antigen and synthetic peptides covering conserved CD4+, CD8+ T cell, and B cell epitopes...
September 8, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/29230430/triethylene-glycol-dimethacrylate-adjuvant-properties-and-effect-on-cytokine-production
#6
Sara Alizadehgharib, Anna-Karin Östberg, Ulf Dahlgren
Objective: Leakage of monomers from dental fillings due to incomplete curing is very common. The objective of the present study was to examine the cytokine profile in cells exposed to triethyleneglycol dimethacrylate (TEGDMA) and the adjuvant properties of TEGDMA. Materials and methods: Human peripheral blood mononuclear cells were exposed to TEGDMA (500 and 1000 μM) for 24 h in vitro. Bio-Plex Pro™ assays were used for analysis and detection of cytokines. In vivo, BALB/c mice were immunized subcutaneously in the base of the tail with TEGDMA in combination with ovalbumin (OVA)...
2018: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/29229733/expression-of-tlr2-by-dendritic-cells-is-essential-for-dnaj-%C3%AE-a146ply-mediated-th1-immune-response-against-streptococcus-pneumoniae
#7
Xiaofang Wang, Taixian Yuan, Jun Yuan, Yufeng Su, Xiaoyu Sun, Jingwen Wu, Hong Zhang, Xun Min, Xuemei Zhang, Yibing Yin
The fusion protein, DnaJ-ΔA146Ply, could induce cross-protective immunity against pneumococcal infection via mucosal and subcutaneous immunization in mice in the absence of additional adjuvants. DnaJ and Ply are both TLR4 but not TLR2 ligands. However, we found that TLR2-/- mice immunized subcutaneously with DnaJ-ΔA146Ply showed significantly lower survival rates and higher bacterial loads in nasal washes than those of WT mice after being challenged with pneumococcal strains D39 or 19F. The IFN-γ level in splenocytes decreased in TLR2-/- mice, indicating that Th1 immunity elicited by DnaJ-ΔA146Ply was impaired in TLR2-/- mice...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29228993/programmed-cell-death-5-transgenic-mice-attenuates-adjuvant-induced-arthritis-by-2-modifying-the-t-lymphocytes-balance
#8
Feng Yuan, Junfeng Wang, Keshi Zhang, Zhao Li, Zhenpeng Guan
BACKGROUND: Programmed cell death 5 (PDCD5) is an apoptosis-related gene cloned from TF-1 cells whose primary biological functions are to promote apoptosis and immune regulation. The effects and mechanisms exerted by key mediators of arthritic inflammation remain unclear in PDCD5 transgenic (PDCD5 tg) mice. RESULTS: In the current study, PDCD5 tg mice inhibited the progression of adjuvant-induced arthritis, specifically decreasing clinical signs and histological damage, compared with arthritis control mice...
December 11, 2017: Biological Research
https://www.readbyqxmd.com/read/29225576/vitamin-d-enhances-efficacy-of-oral-nifedipine-in-treating-preeclampsia-with-severe-features-a-double-blinded-placebo-controlled-and-randomized-clinical-trial
#9
Dan-Dan Shi, Yong Wang, Jun-Jun Guo, Ling Zhou, Na Wang
Vitamin D (VD) has exhibited immunomodulatory role in the pathogenesis of preeclampsia. We hypothesize VD potentiate nifedipine treatment for preeclampsia by shortened the time to control blood pressure and prolong time before subsequent hypertensive crisis. We conduct a randomized trial of 683 primigravid women with preeclampsia, who were assigned to different treatment groups, either nifedipine+placebo or nifedipine+VD orally, by random after screening. Primary endpoints include time to control hypertension and time before another hypertensive crisis...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29222448/effect-of-qianghuo-erhuang-decoction-on-t-regulatory-and-t-helper-17-cells-in-treatment-of-adjuvant-induced-arthritis-in-rats
#10
Can Qian, Mei Kuang, Yong Wang
QianghuoErhuang Decoction (QED) is an effective recipe in treating rheumatoid arthritis. The present study aimed to explore the effects of QED on Treg and Th17 in adjuvant arthritis (AA) model. The study included 6 group rats: normal control group, AA group, AA + methotrexate (MTX) group, AA + high, moderate, and low dose QED groups. The arthritis score was significantly decreased in the MTX and high-dose QED groups compared with the AA group on days 24 and 28 (P < 0.01), respectively. The synovial tissue inflammation was attenuated by histological observation, and the proliferation of splenocytes was significantly inhibited in MTX and high-dose QED groups (P < 0...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29220721/novel-effect-of-methionine-enkephalin-against-influenza-a-virus-infection-through-inhibiting-tlr7-myd88-traf6-nf-%C3%AE%C2%BAb-p65-signaling-pathway
#11
Jing Tian, Xue Jiao, Xiaonan Wang, Jin Geng, Reizhe Wang, Ning Liu, Xinhua Gao, Noreen Griffin, Fengping Shan
The morbidity and mortality associated with influenza A virus infections, have stimulated the search for novel prophylactic and therapeutic drugs. The purpose of this study was to investigate the prophylactic and therapeutic effect of synthetic methionine enkephalin (MENK) on mice infected by A/PR/8/34 influenza virus (H1N1) in vivo. The results showed that MENK could exert both prophylactic and therapeutic influences on infected mice, significantly improve the survival rate, relieve acute lung injury and decrease cytokine (IFN-α, IFN-β, TNF-α, IL-6, and IL-1β) levels...
December 5, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29216926/pro-inflammatory-adjuvant-properties-of-pigment-grade-titanium-dioxide-particles-are-augmented-by-a-genotype-that-potentiates-interleukin-1%C3%AE-processing
#12
Sebastian Riedle, Laetitia C Pele, Don E Otter, Rachel E Hewitt, Harjinder Singh, Nicole C Roy, Jonathan J Powell
BACKGROUND: Pigment-grade titanium dioxide (TiO2) particles are an additive to some foods (E171 on ingredients lists), toothpastes, and pharma-/nutraceuticals and are absorbed, to some extent, in the human intestinal tract. TiO2 can act as a modest adjuvant in the secretion of the pro-inflammatory cytokine interleukin 1β (IL-1β) when triggered by common intestinal bacterial fragments, such as lipopolysaccharide (LPS) and/or peptidoglycan. Given the variance in human genotypes, which includes variance in genes related to IL-1β secretion, we investigated whether TiO2 particles might, in fact, be more potent pro-inflammatory adjuvants in cells that are genetically susceptible to IL-1β-related inflammation...
December 8, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/29214686/myricetin-attenuated-lps-induced-cardiac-injury-in-vivo-and-in-vitro
#13
Nan Zhang, Hong Feng, Hai-Han Liao, Si Chen, Zheng Yang, Wei Deng, Qi-Zhu Tang
Sepsis induced myocardial dysfunction (SIMD) is a common complication and leads to an increased mortality. SIMD is closely related to inflammation and oxidative stress. Myricetin exhibits strong capacities of anti-inflammation and anti-oxidative stress, but its pharmacological effects for lipopolysaccharide (LPS) induced cardiac injury remains undefined. This study aimed to explore whether myricetin was efficient to alleviate SIMD in mice and neonatal rat cardiomyocytes injury. Mice administrated with myricetin (100 mg/kg, po, bid) or vehicle groups were challenged with LPS (10 mg/kg, ip), and cardiac functions examined by echocardiography after 12 hr LPS exposure...
December 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29210292/the-role-of-lpd-nanoparticles-containing-recombinant-major-surface-glycoprotein-of-leishmania-rgp63-in-protection-against-leishmaniasis-in-murine-model
#14
Hengameh Firouzmand, Mehrnosh Sahranavard, Ali Badiee, Ali Khamesipour, Seyedeh Hoda Alavizadeh, Afshin Samiei, Dina Soroush, Masoumeh Tavassoti Kheiri, Fereidoun Mahboudi, Mahmoud Reza Jaafari
CONTEXT: Leishmaniasis is a major public health problem. Despite numerous attempts, yet there is no effective vaccine against human leishmaniasis, mainly due to a lack of an effective vaccine delivery system as well as adjuvant. OBJECTIVE(S): The aim of this study was to evaluate the ability of recombinant glycoprotein 63 (rgp63) as a model of Leishmania antigen, entrapped in liposome-polycation-DNA (LPD) complexes nanoparticles in inducing cell mediated immune (CMI) response and protecting against L...
December 6, 2017: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/29209569/resistance-to-her2-targeted-anti-cancer-drugs-is-associated-with-immune-evasion-in-cancer-cells-and-their-derived-extracellular-vesicles
#15
Vanesa G Martinez, Sadhbh O'Neill, Josephine Salimu, Susan Breslin, Aled Clayton, John Crown, Lorraine O'Driscoll
Neuromedin U (NmU) -a neuropeptide belonging to the neuromedin family- plays a substantial role in HER2-positive breast cancer, correlating with increased aggressiveness, resistance to HER2-targeted therapies and overall significantly poorer outcome for patients. However, the mechanism through which it exerts these effects remains unclear. To elucidate this, initially we used HER2-positive breast cancer cells stably over-expressing NmU. These cells and their released extracellular vesicles (EVs) had increased amounts of the immunosuppressive cytokine TGFβ1 and the lymphocyte activation inhibitor PD-L1...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29209310/alum-activates-the-bovine-nlrp3-inflammasome
#16
Ciaran Harte, Aoife L Gorman, S McCluskey, Michael Carty, Andrew G Bowie, C J Scott, Kieran G Meade, Ed C Lavelle
There has been a move away from vaccines composed of whole or inactivated antigens toward subunit-based vaccines, which although safe, provide less immunological protection. As a result, the use of adjuvants to enhance and direct adaptive immune responses has become the focus of much targeted bovine vaccine research. However, the mechanisms by which adjuvants work to enhance immunological protection in many cases remains unclear, although this knowledge is critical to the rational design of effective next generation vaccines...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29209309/new-directions-for-natural-killer-t-cells-in-the-immunotherapy-of-cancer
#17
Luc Teyton
Natural killer T (NKT) cells have been placed at the interface between innate and adaptive immunity by a long series of experiments that convincingly showed that beyond cytokine secretion and NK cell recruitment, NKT cells were coordinating dendritic cell and B cell maturation through direct membrane contacts and initiate productive responses. As such, NKT cells are the cellular adjuvant of many immune reactions and have functions that go much beyond what their name encapsulates. In addition, the initial discovery of the ligands of NKT cells is deeply linked to cancer biology and therapy...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29207075/blocking-interleukin-6-signaling-inhibits-cell-viability-proliferation-glycolysis-and-colony-forming-activity-of-human-medulloblastoma-cells
#18
Xiang Chen, Jia Wei, Chenglong Li, Christopher R Pierson, Jonathan L Finlay, Jiayuh Lin
Elevated levels of the pro-inflammatory cytokine interleukin-6 (IL‑6) have tumor-promoting activity and are associated with poor survival outcomes in many cancers. Additionally, the IL‑6/GP130/STAT3 axis has been widely studied due to its pivotal role in tumor development and maintenance in a number of tissue types, including the cerebellum. However, the connection between IL‑6 signaling and medulloblastoma progression is largely unexplored. In the present study, we observed that IL‑6 induced medulloblastoma cell viability, cell proliferation and glycolysis...
November 22, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29204451/targeting-of-immune-cells-by-dual-tlr2-7-ligands-suppresses-features-of-allergic-th2-immune-responses-in-mice
#19
Jonathan Laiño, Andrea Wangorsch, Frank Blanco, Sonja Wolfheimer, Maren Krause, Adam Flaczyk, Tobias-Maximilian Möller, Mindy Tsai, Stephen Galli, Stefan Vieths, Masako Toda, Stephan Scheurer, Stefan Schülke
Background: TLR ligands can promote Th1-biased immune responses, mimicking potent stimuli of viruses and bacteria. Aim: To investigate the adjuvant properties of dual TLR2/7 ligands compared to those of the mixture of both single ligands. Methods: Dual TLR2/7 ligands: CL401, CL413, and CL531, including CL264 (TLR7-ligand) and Pam2CysK4 (TLR2-ligand), were used. Immune-modulatory capacity of the dual ligands with the individual ligands alone or as a mixture in mouse BMmDCs, BMmDC:TC cocultures, or BMCMCs was compared and assessed in naïve mice and in a mouse model of OVA-induced intestinal allergy...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/29202842/preclinical-and-clinical-aspects-of-tnf-%C3%AE-and-its-receptors-tnfr1-and-tnfr2-in-breast-cancer
#20
REVIEW
Isela Martínez-Reza, Lorenza Díaz, Rocío García-Becerra
Breast cancer is the most common malignancy in women and a public health problem worldwide. Breast cancer is often accompanied by an inflammatory process characterized by the presence of proinflammatory cytokines such as tumor necrosis factor (TNF-α), which has important implications in the course of the disease. Inflammation has been described primarily as a favorable environment for tumor development. However, under certain conditions TNF-α can promote signals for activation, differentiation, survival or cell death, so the study of the variants of this cytokine, its receptors, the presence of polymorphisms and its implication in different phenotypes of breast cancer is necessary...
December 4, 2017: Journal of Biomedical Science
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