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https://www.readbyqxmd.com/read/29676690/does-size-matter-investigating-the-optimal-planning-target-volume-margin-for-postoperative-stereotactic-radiosurgery-to-resected-brain-metastases
#1
Jaymin Jhaveri, Mudit Chowdhary, Xinyan Zhang, Robert H Press, Jeffrey M Switchenko, Matthew J Ferris, Tiffany M Morgan, Justin Roper, Anees Dhabaan, Eric Elder, Bree R Eaton, Jeffrey J Olson, Walter J Curran, Hui-Kuo G Shu, Ian R Crocker, Kirtesh R Patel
OBJECTIVE The optimal margin size in postoperative stereotactic radiosurgery (SRS) for brain metastases is unknown. Herein, the authors investigated the effect of SRS planning target volume (PTV) margin on local recurrence and symptomatic radiation necrosis postoperatively. METHODS Records of patients who received postoperative LINAC-based SRS for brain metastases between 2006 and 2016 were reviewed and stratified based on PTV margin size (1.0 or > 1.0 mm). Patients were treated using frameless and framed SRS techniques, and both single-fraction and hypofractionated dosing were used based on lesion size...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29675597/upregulated-epithelial-junction-expression-represents-a-novel-parameter-of-the-epithelial-radiation-response-to-fractionated-irradiation-in-oral-mucosa
#2
Sylvia Gruber, Nilsu Cini, Lisa-Marie Kowald, Julia Mayer, Andreas Rohorzka, Peter Kuess, Wolfgang Dörr
PURPOSE: During head and neck cancer treatment, the radiation response of the oral mucosa represents a frequent early side effect. Besides radiation-induced inhibition of proliferation, various other cellular responses occur. The radiation response of adherens and tight junction proteins was so far mostly investigated with large single-dose irradiation protocols, in vivo and in vitro. Therefore, the current study was initiated to investigate the impact of daily fractionated irradiation on the expression of adherens and tight junction proteins in vivo...
April 19, 2018: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29675417/developing-a-reliable-mouse-model-for-cancer-therapy-induced-cardiovascular-toxicity-in-cancer-patients-and-survivors
#3
Kyung Ae Ko, Yin Wang, Sivareddy Kotla, Yuka Fujii, Hang Thi Vu, Bhanu P Venkatesulu, Tamlyn N Thomas, Jan L Medina, Young Jin Gi, Megumi Hada, Jane Grande-Allen, Zarana S Patel, Sarah A Milgrom, Sunil Krishnan, Keigi Fujiwara, Jun-Ichi Abe
Background: The high incidence of cardiovascular events in cancer survivors has long been noted, but the mechanistic insights of cardiovascular toxicity of cancer treatments, especially for vessel diseases, remain unclear. It is well known that atherosclerotic plaque formation begins in the area exposed to disturbed blood flow, but the relationship between cancer therapy and disturbed flow in regulating plaque formation has not been well studied. Therefore, we had two goals for this study; (1) Generate an affordable, reliable, and reproducible mouse model to recapitulate the cancer therapy-induced cardiovascular events in cancer survivors, and (2) Establish a mouse model to investigate the interplay between disturbed flow and various cancer therapies in the process of atherosclerotic plaque formation...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29674243/application-of-spectral-methods-for-studying-dna-damage-induced-by-gamma-radiation
#4
Svetlana A Tankovskaia, Omar M Kotb, Olga A Dommes, Sofia V Paston
Spectral methods can provide a variety of possibilities to determine several types of radiation-induced DNA damage, such as nucleobase destruction and local denaturation. DNA UV absorption and CD spectra measured at room temperature undergo noticeable alteration under the action of γ-radiation. We have applied the Spirin method of total nucleobases determination, and have measured the molar extinction coefficient of DNA and DNA CD spectra for solutions with different NaCl concentrations (3mM-3.2M) and containing MgCl2 , exposed to γ-radiation with the doses of 0-103 Gy...
April 10, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29673384/prognostic-factors-of-radiation-dermatitis-following-passive-scattering-proton-therapy-for-breast-cancer
#5
Xiaoying Liang, Julie A Bradley, Dandan Zheng, Michael Rutenberg, Daniel Yeung, Nancy Mendenhall, Zuofeng Li
BACKGROUND: To identify prognostic factors for grade 3 radiation dermatitis following passive-scattering proton therapy for breast cancer. METHODS: This retrospective study included data on 23 (11 post-mastectomy and 12 post-lumpectomy) breast cancer patients who underwent proton therapy with the passive scattering technique in our institute from 2012 to 2016. Each patient received 50-50.4 cobalt Gy equivalent (CGE) at 1.8 or 2 CGE per daily fraction. Logistic regression analysis was performed to identify prognostic factors for grade 3 skin toxicity...
April 19, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29673383/radiotherapy-for-calcaneodynia-achillodynia-painful-gonarthrosis-bursitis-trochanterica-and-painful-shoulder-syndrome-early-and-late-results-of-a-prospective-clinical-quality-assessment
#6
Oliver Micke, Eyup Ugrak, Stefan Bartmann, Irenaeus A Adamietz, Ulrich Schaefer, Rebecca Bueker, Klaus Kisters, M Heinrich Seegenschmiedt, Khashayar Fakhrian, Ralph Muecke
BACKGROUND: The aim of this prospective clinical quality assessment was to evaluate the short-term and long-term efficacy of low dose radiotherapy (RT) for calcaneodynia, achillodynia, painful gonarthrosis, painful bursitis trochanterica, and painful shoulder syndrome. METHODS: Between October 2011 and October 2013, patients with calcaneodynia, achillodynia, painful gonarthrosis, painful bursitis trochanterica, and painful shoulder syndrome were recruited for this prospective clinical quality assessment...
April 19, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29672544/stress-pre-conditioning-with-temperature-uv-and-gamma-radiation-induces-tolerance-against-phosphine-toxicity
#7
Saad M Alzahrani, Paul R Ebert
Phosphine is the only general use fumigant for the protection of stored grain, though its long-term utility is threatened by the emergence of highly phosphine-resistant pests. Given this precarious situation, it is essential to identify factors, such as stress preconditioning, that interfere with the efficacy of phosphine fumigation. We used Caenorhabditis elegans as a model organism to test the effect of pre-exposure to heat and cold shock, UV and gamma irradiation on phosphine potency. Heat shock significantly increased tolerance to phosphine by 3-fold in wild-type nematodes, a process that was dependent on the master regulator of the heat shock response, HSF-1...
2018: PloS One
https://www.readbyqxmd.com/read/29672241/scintillation-yield-estimates-of-colloidal-cerium-doped-laf-3-nanoparticles-and-potential-for-deep-pdt
#8
Konstantin A Kudinov, Daniel R Cooper, Jonathan K Ha, Colin K Hill, Jay L Nadeau, Jan P Seuntjens, Stephen E Bradforth
A hybrid of radiotherapy and photodynamic therapy (PDT) has been proposed in previously reported studies. This approach utilizes scintillating nanoparticles to transfer energy to attached photosensitizers, thus generating singlet oxygen for local killing of malignant cells. Its effectiveness strongly depends upon the scintillation yield of the nanoparticles. Using a liquid scintillator as a reference standard, we estimated the scintillation yield of Ce0.1 La0.9 F3 /LaF3 core/shell nanoparticles at 28.9 mg/ml in water to be 350 photons/MeV under orthovoltage X-ray irradiation...
April 19, 2018: Radiation Research
https://www.readbyqxmd.com/read/29671690/application-of-a-novel-murine-ear-vein-model-to-evaluate-the-effects-of-a-vascular-radioprotectant-on-radiation-induced-vascular-permeability-and-leukocyte-adhesion
#9
Kathleen A Ashcraft, Kingshuk Roy Choudhury, Sam R Birer, Hansford C Hendargo, Pranalee Patel, Gary Eichenbaum, Mark W Dewhirst
Vascular injury after radiation exposure contributes to multiple types of tissue injury through a cascade of events. Some of the earliest consequences of radiation damage include increased vascular permeability and promotion of inflammation, which is partially manifested by increased leukocyte-endothelial (L/E) interactions. We describe herein a novel intravital imaging method to evaluate L/E interactions, as a function of shear stress, and vascular permeability at multiple time points after local irradiation to the ear...
April 19, 2018: Radiation Research
https://www.readbyqxmd.com/read/29671003/effects-of-nitrogen-and-phosphorous-stress-on-the-formation-of-high-value-lc-pufas-in-porphyridium-cruentum
#10
Hao Hu, Hou-Feng Wang, Lin-Lin Ma, Xiao-Fei Shen, Raymond Jianxiong Zeng
This study systematically examined the effect of nitrogen and phosphorous stress on the formation of linoleic acid (LA), arachidonic acid (ARA), and eicosapentaenoic acid (EPA) in Porphyridium cruentum gy-h56. P. cruentum was cultivated in six different media conferring different conditions of nitrogen (N) sufficiency/deprivation and phosphorous (P) sufficiency/limitation/deprivation. Over a 16-day cultivation process, the dry-weight content, proportion of total fatty acids (TFAs), and the concentration in the medium of linoleic acid (LA) were greatly improved by a maximum of 2...
April 18, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29669181/racial-disparity-in-oncologic-and-quality-of-life-outcomes-in-patients-with-locally-advanced-head-and-neck-squamous-cell-carcinomas-enrolled-in-a-randomized-phase-2-trial
#11
Margaret K Guerriero, Mary W Redman, Kelsey K Baker, Renato G Martins, Keith Eaton, Laura Q Chow, Rafael Santana-Davila, Christina Baik, Bernardo H Goulart, Sylvia Lee, Cristina P Rodriguez
BACKGROUND: To better understand patient-reported quality of life (PRQOL) for patients with head and neck cancer, PRQOL scores were collected in a clinical trial. METHODS: Patients were randomized to arm A (70 Gy of radiation with cisplatin) or arm B (70 Gy of radiation with cisplatin plus erlotinib at 150 mg daily). PRQOL scores were measured on days -7 (arm B only), 0, 30, and 180 with the University of Washington Quality of Life Questionnaire. Associations with clinical factors and outcomes were explored with linear mixed, logistic, and Cox regression models...
April 18, 2018: Cancer
https://www.readbyqxmd.com/read/29667481/effects-of-ionising-radiation-on-telomere-length-and-telomerase-activity-in-cultured-human-lens-epithelium-cells
#12
Savneet Kaur Bains, Kim Chapman, Scott Bright, Anish Senan, Munira Kadhim, Predrag Slijepcevic
PURPOSE: To investigate the effects of ionising radiation on telomere length and telomerase activity in Human Lens Epithelial cells. There are studies suggesting evidence of telomere length in association with opacity of the lens, however, these studies have been conducted on Canine Lens cells. Our study was designed to understand further the effects of different doses of ionising radiation on telomere length and telomerase activity in cultured Human Lens Epithelium cells from three Donors...
April 18, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29667293/enhanced-in-vitro-biocompatibility-and-water-dispersibility-of-magnetite-and-cobalt-ferrite-nanoparticles-employed-as-ros-formation-enhancer-in-radiation-cancer-therapy
#13
Stefanie Klein, Melek Kızaloğlu, Luis Portilla, Hyoungwon Park, Tobias Rejek, Julian Hümmer, Karsten Meyer, Rainer Hock, Luitpold V R Distel, Marcus Halik, Carola Kryschi
Efficient magnetic reactive oxygen species (ROS) formation enhancing agents after X-ray treatment are realized by functionalizing superparamagnetic magnetite (Fe3 O4 ) and Co-ferrite (CoFe2 O4 ) nanoparticles with self-assembled monolayers (SAMs). The Fe3 O4 and CoFe2 O4 nanoparticles are synthesized using Massart's coprecipitation technique. Successful surface modification with the SAM forming compounds 1-methyl-3-(dodecylphosphonic acid) imidazolium bromide, or (2-{2-[2-hydroxy-ethoxy]-ethoxy}-ethyl phosphonic acid provides biocompatibility and long-term stability of the Fe3 O4 and CoFe2 O4 nanoparticles in cell media...
April 18, 2018: Small
https://www.readbyqxmd.com/read/29667085/long-term-hearing-outcomes-after-gamma-knife-surgery-in-patients-with-vestibular-schwannoma-with-hearing-preservation-evaluation-in-92-patients-with-serial-audiograms
#14
Toshinori Hasegawa, Takenori Kato, Takashi Yamamoto, Takehiro Naito, Naoki Kato, Jun Torii, Kazuki Ishii
The treatment strategy for patients with vestibular schwannoma (VS) is controversial, and data concerning the long-term hearing outcomes > 5 years after gamma knife surgery (GKS) are limited. The long-term hearing outcomes after GKS were evaluated in VS patients with hearing preservation. Ninety-two VS patients with a pure tone average (PTA) ≤ 50 dB were evaluated. The median age was 54 years; the median tumor volume was 1.5 cm3 . The tumors were treated with a median margin dose of 12 Gy and a median mean cochlear dose of 4...
April 17, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29667046/radiotherapy-in-patients-with-cardiac-implantable-electronic-devices-clinical-and-dosimetric-aspects
#15
Giulia Riva, Ombretta Alessandro, Ruggero Spoto, Annamaria Ferrari, Cristina Garibaldi, Federica Cattani, Rosa Luraschi, Elena Rondi, Nicola Colombo, Fulvio Lorenzo Francesco Giovenzana, Carlo Maria Cipolla, Mikolaj Winnicki, Martina Persiani, Fabiana Castelluccia, Massimo Sarra Fiore, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
As a result of aging, the number of patients with cardiac implantable electronic device (CIED) requiring radiotherapy (RT) continues to rise. The aim of this work was to evaluate RT-related malfunctions of CIED in a cohort of patients who underwent RT in our clinic from June 2010 to December 2016. We retrospectively analyzed 93 RT treatments in 63 patients with CIEDs. Patients were treated with 3D conformal RT, intensity-modulated RT and stereotactic RT. We collected clinical characteristics of cancer, models of CIEDs, total RT dose to tumor and radiation energy...
April 17, 2018: Medical Oncology
https://www.readbyqxmd.com/read/29666802/advances-in-radiotherapy-for-esophageal-cancer
#16
REVIEW
Wei Deng, Steven H Lin
Esophageal cancer is a common type of malignancy worldwide and usually requires multidisciplinary care. Radiotherapy plays an important part in management of the disease. During the past few years, researchers have made much progress about radiotherapy for esophageal cancer, which was revealed in every aspect of clinical practice. Neoadjuvant chemoradiotherapy remains the standard treatment for locally advanced esophageal cancer, whereas neoadjuvant chemotherapy appears to show less toxicities and non-inferior prognosis...
February 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29665832/volumetric-and-dosimetric-comparison-of-organs-at-risk-between-the-prone-and-supine-positions-in-postoperative-radiotherapy-for-prostate-cancer
#17
Subaru Sawayanagi, Hideomi Yamashita, Mami Ogita, Tomoki Kiritoshi, Takahiro Nakamoto, Osamu Abe, Keiichi Nakagawa
BACKGROUND: The aim of this study was to evaluate the effects of patient positioning on the volume of organs at risk (OARs) in or near the planning target volume (PTV) and the dose distribution in adjuvant or salvage radiotherapy for prostate cancer after prostatectomy. METHODS: Seventeen patients who received intensity-modulated radiation therapy (66 Gy in 33 fractions) as adjuvant or salvage therapy after prostatectomy were evaluated. All patients underwent CT scans in both the prone (on a belly board) and supine positions...
April 17, 2018: Radiation Oncology
https://www.readbyqxmd.com/read/29665670/-the-relationship-between-the-radioresistance-of-pancreatic-cancer-cell-sw1990-and-the-induction-of-the-epithelial-mesenchymal-transition-an-in-vitro-study
#18
Y H Jiang, K Y You, Z F Bi, L T Li, H Q Mo, Y M Liu
Objective: To investigate the relationship between the radioresistance of pancreatic cancer cell SW1990 and the induction of the Epithelial-Mesenchymal Transition (EMT). Methods: The radio-resistant pancreatic cancer cell SW1990-R were established by using the method of radiating pancreatic cancer cell SW1990 step by step and repeatedly. Then the changes of the morphology of the cell was observed by inverted phase contrast microscope, the radioresistance of SW1990-R was detected by colony-forming assay, and the apoptosis rate of the two cell lines after radiation were measured by flow cytometry...
March 27, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29664796/long-term-outcomes-with-ifosfamide-based-hypofractionated-preoperative-chemoradiotherapy-for-extremity-soft-tissue-sarcomas
#19
Joseph Daniel Pennington, Fritz C Eilber, Frederick R Eilber, Arun S Singh, Jarred P Reed, Bartosz Chmielowski, Jeffrey J Eckardt, Susan V Bukata, Nicholas M Bernthal, Noah Federman, Scott D Nelson, Sarah M Dry, Pin-Chieh Wang, Michael Luu, Michael T Selch, Michael L Steinberg, Anusha Kalbasi, Mitchell Kamrava
OBJECTIVES: The objective of this study was to analyze outcomes for patients with soft tissue sarcoma of the extremities using neoadjuvant ifosfamide-based chemotherapy and hypofractionated reduced dose radiotherapy, followed by limb-sparing surgery. MATERIALS AND METHODS: An Institutional Review Board (IRB)-approved retrospective review of patients treated at a single institution between 1990 and 2013 was performed. In total, 116 patients were identified who received neoadjuvant ifosfamide-based chemotherapy and 28 Gy in 8 fractions of preoperative radiation (equivalent dose in 2 Gray fractions, 31...
April 16, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29664715/late-infection-related-mortality-in-asplenic-survivors-of-childhood-cancer-a-report-from-the-childhood-cancer-survivor-study
#20
Brent R Weil, Arin L Madenci, Qi Liu, Rebecca M Howell, Todd M Gibson, Yutaka Yasui, Joseph P Neglia, Wendy M Leisenring, Susan A Smith, Emily S Tonorezos, Danielle N Friedman, Louis S Constine, Christopher L Tinkle, Lisa R Diller, Gregory T Armstrong, Kevin C Oeffinger, Christopher B Weldon
Purpose Infection-related outcomes associated with asplenia or impaired splenic function in survivors of childhood cancer remains understudied. Methods Late infection-related mortality was evaluated in 20,026 5-year survivors of childhood cancer (diagnosed < 21 years of age from 1970 to 1999; median age at diagnosis, 7.0 years [range, 0 to 20 years]; median follow-up, 26 years [range, 5 to 44 years]) using cumulative incidence and piecewise-exponential regression models to estimate adjusted relative rates (RRs)...
April 17, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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