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https://www.readbyqxmd.com/read/29916602/-stochastic-effects-of-ionizing-radiations
#1
Lorenzo Bordini, Giuseppe Taino
OBJECTIVES: Stochastic effects induced by exposure to ionizing radiation rapresent a relevance radioprotection aspect. METHODS: Actually most of the information about radiation-induced oncogenic risk arise from the follow-up of the atomic bombs survivors (Life Span Study, LSS); at this information sources have been added over the last decades also data derived from medical, occupational and environmental studies conducted in various parts of the world and their contribution about number of cases and duration of follow-up period is of great relevance...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916117/mapping-bone-marrow-response-in-the-vertebral-column-by-positron-emission-tomography-following-radiotherapy-and-erlotinib-therapy-of-lung-cancer
#2
Azadeh Abravan, Hanne Astrid Eide, Ayca Muftuler Løndalen, Åslaug Helland, Eirik Malinen
PURPOSE: To map functional bone marrow (BM) by 2-deoxy-2-[18 F]fluoro-D-glucose ([18 F]FDG) positron emission tomography (PET) in the vertebral column of lung cancer patients prior to, during, and after treatment. Moreover, to identify radiation- and erlotinib-induced changes in the BM. PROCEDURES: Twenty-six patients with advanced non-small cell lung cancer, receiving radiotherapy (RT) alone or concomitantly with erlotinib, were examined by [18 F]FDG PET before, during, and after treatment...
June 18, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29915802/laparoscopic-ovarian-transposition-prior-to-pelvic-radiation-for-gynecologic-cancer
#3
Brenna E Swift, Eric Leung, Danielle Vicus, Allan Covens
This study evaluates a novel technique of laparoscopic ovarian transposition performed by Gynecologic Oncologists prior to pelvic radiation for gynecologic cancer. A retrospective review was completed of all patients that underwent laparoscopic ovarian transposition from February 2007 to June 2017 at one tertiary care cancer. The technique involves salpingectomy, followed by retroperitoneal dissection to move the ovaries lateral to the hepatic and splenic flexures of the colon. Normal ovarian function was defined by the absence of vasomotor symptoms, FSH and menstrual history (if menstruating)...
May 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29915168/clinical-effect-of-radiotherapy-combined-with-chemotherapy-for-non-surgical-treatment-of-the-esophageal-squamous-cell-carcinoma
#4
Hongmin Chen, Lei Zhou, Yunli Yang, Liuting Yang, Long Chen
BACKGROUND Chemoradiotherapy (CRT) is widely accepted and is considered a standard treatment, particularly for unresectable and inoperable esophageal squamous cell carcinoma (ESCC). However, the optimal use of the combined modalities of chemotherapy (CT) and radiotherapy (RT) remains controversial. In addition, no consensus has been reached regarding the exact efficacy of consolidation chemotherapy (CCT) and the most appropriate radiotherapy dose. MATERIAL AND METHODS Clinical data from 262 ESCC patients treated with CRT (n=165) or RT alone (n=97) were collected and reviewed...
June 19, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29914796/convection-enhanced-delivery-for-diffuse-intrinsic-pontine-glioma-a-single-centre-dose-escalation-phase-1-trial
#5
Mark M Souweidane, Kim Kramer, Neeta Pandit-Taskar, Zhiping Zhou, Sofia Haque, Pat Zanzonico, Jorge A Carrasquillo, Serge K Lyashchenko, Sunitha B Thakur, Maria Donzelli, Ryan S Turner, Jason S Lewis, Nai-Kong V Cheung, Steven M Larson, Ira J Dunkel
BACKGROUND: Diffuse intrinsic pontine glioma is one of the deadliest central nervous system tumours of childhood, with a median overall survival of less than 12 months. Convection-enhanced delivery has been proposed as a means to efficiently deliver therapeutic agents directly into the brainstem while minimising systemic exposure and associated toxic effects. We did this study to evaluate the safety of convection-enhanced delivery of a radioimmunotherapy agent targeting the glioma-associated B7-H3 antigen in children with diffuse intrinsic pontine glioma...
June 15, 2018: Lancet Oncology
https://www.readbyqxmd.com/read/29914648/long-term-risks-of-secondary-cancer-for-various-whole-and-partial-breast-irradiation-techniques
#6
Nienke Hoekstra, Emmanuelle Fleury, Tomas Rodrigo Merino Lara, Peter van der Baan, Andy Bahnerth, Gerson Struik, Mischa Hoogeman, Jean-Philippe Pignol
INTRODUCTION: For early stage breast cancer patients, non-breast cancer mortality including secondary cancers and cardiac events can overshadow the benefit of adjuvant radiotherapy. This study evaluates the excess risk of secondary cancer for various breast radiotherapy techniques including accelerated partial breast irradiation (APBI). METHODS: Secondary cancers Lifetime Attributable Risks (LAR) were calculated using a modified BEIR-VII formalism to account for the specific survival of breast cancer patients...
June 15, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29913104/impact-of-gamma-irradiation-on-the-development-and-reproduction-of-culex-pipiens-diptera-culicidae
#7
Ahmed I Hasaballah
PURPOSE: The aim was to evaluate the effects of irradiation of Culex pipiens irradiated as pupae on the larval and pupal mortality percentages, the larval and pupal duration, adult emergence percentages and ovarian development in comparison with the un-irradiated group. MATERIAL AND METHODS: the mosquito, C. pipiens Linnaeus (L) was irradiated as pupae with three gamma doses 40, 60 and 80 Gy. Different biological aspects include the ovarian development of irradiated females tested...
June 18, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29912936/low-dose-ionizing-radiation-exposure-represses-the-cell-cycle-and-protein-synthesis-pathways-in-in-vitro-human-primary-keratinocytes-and-u937-cell-lines
#8
Kazumasa Sekihara, Kaori Saitoh, Haeun Yang, Haruki Kawashima, Saiko Kazuno, Mika Kikkawa, Hajime Arai, Takashi Miida, Nobuhiro Hayashi, Keisuke Sasai, Yoko Tabe
The effects of the high-dose ionizing radiation used in radiotherapy have been thoroughly demonstrated in vitro and in vivo. However, the effects of low-dose ionizing radiation (LDIR) such as computed tomography-guided biopsies and X-ray fluoroscopy on skin cells remain controversial. This study investigated the molecular effects of LDIR on the human primary keratinocytes (HPKs) and U937 cells, monocytes-like cell lines. These cells were exposed to 0.1 Gray (Gy) X-ray as LDIR. The modulation of transcription was assessed using a cDNA array, and the protein expression after LDIR exposure was investigated using isobaric tags for relative and absolute quantification (iTRAQ) proteomic analysis at 24 hours...
2018: PloS One
https://www.readbyqxmd.com/read/29912595/ionizing-radiation-reduces-the-capacity-of-activated-macrophages-to-induce-t-cell-proliferation-but-does-not-trigger-dendritic-cell-mediated-non-targeted-effects
#9
Roland Wunderlich, Paul Friedrich Rühle, Lisa Deloch, Franz Roedel, Rainer Fietkau, Udo S Gaipl, Benjamin Frey
PURPOSE: Previous investigations revealed influences of irradiation up to 2.0 Gy on the cytokine secretion profile of inflammatory, peritoneal mouse macrophages (pMФ). This raised the question if those alterations impact on dendritic cells and consecutive T-cell responses. Further, the impact of irradiation directly on pMФ capacity to induce T-cell responses was analyzed. MATERIALS AND METHODS: pMФ were LPS-activated, irradiated and the expression of activation markers was assessed...
June 18, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29910832/phase-i-ii-study-on-kilovoltage-surface-brachytherapy-in-conjunctival-cancer-preliminary-results
#10
Gustavo R Sarria, Gustavo J Sarria, Paola Fuentes Rivera, Mayer Zaharia, Solón Serpa, Mario Buitrago
Introduction: In ocular conjunctival carcinoma after surgery, adjuvant treatment has a role and kilovoltage surface brachytherapy opens a new door for the range of therapeutic options. Materials and methods: Between October 2014 and June 2017, at the National Institute of Neoplastic Diseases (INEN) from Peru, 39 patients with squamous cell carcinoma of ocular conjunctiva, T1-T3, resected, were selected to receive adjuvant treatment. The portable accelerator of 50-kV INTRABEAM (Carl Zeiss Meditec) was used, after local anaesthesia and blocking of ocular muscles movement...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29909895/magnitude-of-benefit-for-adjuvant-radiotherapy-following-minimally-invasive-surgery-in-intermediate-to-high-risk-hpv-positive-oropharyngeal-squamous-cell-carcinoma
#11
Dario Pasalic, Ryan K Funk, Joaquín J García, Daniel L Price, Katharine A Price, William S Harmsen, Samir H Patel, Geoffrey D Young, Robert L Foote, Eric J Moore, Daniel J Ma
OBJECTIVE: To determine the outcomes and toxicities of minimally-invasive surgery with adjuvant intensity-modulated radiotherapy +/- chemotherapy (AT) compared to definitive surgical therapy (ST) in a contemporary cohort of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC). METHODS: From 2005 to 2013, a consecutive cohort of 190 HPV-positive OPSCC patients was retrospectively reviewed from multi-institutional databases maintained by the Departments of Otorhinolaryngology and Radiation Oncology...
July 2018: Oral Oncology
https://www.readbyqxmd.com/read/29909419/outcomes-of-local-excision-plus-chemoradiotherapy-in-patients-with-t1-rectal-cancer
#12
Toshiyuki Suzuki, Sotaro Sadahiro, Akira Tanaka, Kazutake Okada, Gota Saito, Hiroshi Miyakita, Takeshi Akiba, Hiroshi Yamamuro
OBJECTIVE: The National Comprehensive Cancer Network (NCCN) guidelines recommend local excision and observation as standard treatment for selected patients with clinical T1N0M0 rectal cancer. In patients with pathological T1 (pT1) rectal cancer who received local excision, the local recurrence rate is at least 10%. We studied oncological outcomes in patients with pT1 rectal cancer who received chemoradiotherapy (CRT) after local excision. METHODS: Local excision was performed in 65 patients with clinical T1N0M0 rectal cancer (≤8 cm from the anal verge, tumor size < 30 mm, well or moderately differentiated adenocarcinoma)...
June 15, 2018: Oncology
https://www.readbyqxmd.com/read/29908871/an-overview-on-personalisation-of-radiotherapy-prescriptions-in-locally-advanced-non-small-cell-lung-cancer-are-we-there-yet
#13
REVIEW
Sarah Barrett, Gerard G Hanna, Laure Marignol
Standard of care radiotherapy in LA-NSCLC is 60-66 Gy in 30-33 fractions. However outcomes for these patients are poor with 5-year survival in the range of 10-20%. Randomised controlled trials have shown that dose escalation in a linear fashion does not improve outcomes for all patients, thus there is a need to tailor the prescription to the individual patient. This review assesses the strategies published to personalise the radiation therapy dose prescription in LA-NSCLC. A systematic and scoping search of the literature was performed to identify studies that met the inclusion criteria...
June 13, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29908790/association-of-neuronal-injury-in-the-genu-and-body-of-corpus-callosum-after-cranial-irradiation-in-children-with-impaired-cognitive-control-a-prospective-study
#14
Kristin J Redmond, Meghan Hildreth, Haris I Sair, Stephanie Terezakis, Todd McNutt, Lawrence Kleinberg, Kenneth J Cohen, Moody Wharam, Alena Horska, E Mark Mahone
PURPOSE: Brain radiation is associated with functional deficits in children. The purpose of this study was to examine white matter integrity as measured by diffusion tensor imaging and associations with region-specific radiation dose and neuropsychological functioning in children treated with cranial irradiation. METHODS AND MATERIALS: A total of 20 patients and 55 age- and sex-matched controls were included in the present study. Diffusion tensor imaging and neuropsychological assessments were conducted at baseline and 6, 15, and 27 months after treatment...
April 22, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29908486/radiation-therapy-affects-the-mechanical-behavior-of-human-umbilical-vein-endothelial-cells
#15
Alireza Mohammadkarim, Mohammad Tabatabaei, Azim Parandakh, Manijhe Mokhtari-Dizaji, Mohammad Tafazzoli-Shadpour, Mohammad-Mehdi Khani
Radiation therapy has been widely utilized as an effective method to eliminate malignant tumors and cancerous cells. However, subjection of healthy tissues and the related networks of blood vessels adjacent to the tumor area to irradiation is inevitable. The aim of this study was to investigate the consequent effects of fractionation radiotherapy on the mechanical characteristics of human umbilical vein endothelial cells (HUVECs) through alterations in cytoskeleton organization and cell and nucleus morphology...
June 6, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29907505/personalized-automated-treatment-planning-for-breast-plus-locoregional-lymph-nodes-using-hybrid-rapidarc
#16
Mariët J van Duren-Koopman, Jim P Tol, Max Dahele, Ewa Bucko, Philip Meijnen, Ben J Slotman, Wilko F Verbakel
PURPOSE: Breast cancer patients who require locoregional lymph node (LLN) irradiation can be treated using a hybrid RapidArc technique combining 2 tangential and 3 RapidArc fields. Because the creation of hybrid RapidArc plans is complex and labor-intensive, we developed an automated treatment planning workflow using the scripting application programming interface of the Eclipse treatment planning system. METHODS AND MATERIALS: Fifteen patients (5 right- and 10 left-sided) previously treated with breast + LLN radiation therapy were replanned using the script...
March 26, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29907502/functional-liver-image-guided-hepatic-therapy-flight-with-hepatobiliary-iminodiacetic-acid-hida-scans
#17
David E Long, Mark Tann, Ke Colin Huang, Gregory Bartlett, James O Galle, Yukie Furukawa, Mary Maluccio, John A Cox, Feng-Ming Spring Kong, Susannah G Ellsworth
PURPOSE: Hepatobiliary iminodiacetic acid (HIDA) scans provide global and regional assessments of liver function that can serve as a road map for functional avoidance in stereotactic body radiation therapy (SBRT) planning. Functional liver image guided hepatic therapy (FLIGHT), an innovative planning technique, is described and compared with standard planning using functional dose-volume histograms. Thresholds predicting for decompensation during follow up are evaluated. METHODS AND MATERIALS: We studied 17 patients who underwent HIDA scans before SBRT...
May 1, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29907490/multi-institutional-study-of-carbon-ion-radiotherapy-for-locally-advanced-pancreatic-cancer-japan-carbon-ion-radiation-oncology-study-group-j-cros-study-1403-pancreas
#18
Shohei Kawashiro, Shigeru Yamada, Masahiko Okamoto, Tatsuya Ohno, Takashi Nakano, Makoto Shinoto, Yoshiyuki Shioyama, Kenji Nemoto, Yuka Isozaki, Hiroshi Tsuji, Tadashi Kamada
PURPOSE: The aim of this multi-institutional study was to evaluate the efficacy and safety of carbon-ion radiotherapy (C-ion RT) for locally advanced pancreatic cancer (LAPC). METHODS AND MATERIALS: Patients with LAPC treated with C-ion RT from April 2012 to December 2014 at 3 institutions were retrospectively analyzed. Patients with pathologically-confirmed invasive ductal adenocarcinoma of the pancreas were eligible. The prescribed dose was 52.8 Gy (relative biological effectiveness weighted absorbed dose; RBE) or 55...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29907489/extended-field-chemoradiation-therapy-for-definitive-treatment-of-anal-canal-squamous-cell-carcinoma-involving-the-para-aortic-lymph-nodes
#19
Emma B Holliday, Scott C Lester, W Scott Harmsen, Cathy Eng, Michael G Haddock, Sunil Krishnan, Prajnan Das, Christopher L Hallemeier
PURPOSE: To report cancer control rates and adverse events (AEs) of curative-intent, extended-field chemoradiation therapy administered to patients with squamous cell carcinoma (SCC) of the anal canal presenting with distant metastasis limited to the para-aortic (PA) lymph nodes. METHODS: This was a retrospective review of patients with SCC of the anal canal metastatic to the PA lymph nodes at initial diagnosis who were treated with curative-intent, extended-field chemoradiation therapy between September 2002 and February 2016 at two tertiary care centers...
May 5, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29907488/correlation-of-regional-lung-ventilation-and-gas-transfer-to-red-blood-cells-implications-for-functional-avoidance-radiation-therapy-planning
#20
Leith J Rankine, Ziyi Wang, Bastiaan Driehuys, Lawrence B Marks, Chris R Kelsey, Shiva K Das
PURPOSE: To investigate the degree to which lung ventilation and gas exchange are regionally correlated, using the emerging technology of hyperpolarized (HP)-129 Xe magnetic resonance imaging (MRI). METHODS AND MATERIALS: Hyperpolarized-129 Xe MRI studies were performed on 17 institutional review board-approved human subjects, including 13 healthy volunteers, 1 emphysema patient, and 3 non-small cell lung cancer patients imaged before and approximately 11 weeks after radiation therapy (RT)...
April 14, 2018: International Journal of Radiation Oncology, Biology, Physics
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